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MTTTDNTAHAGTQTIDELVPSRYAVQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDIL DWPLNVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVLTHLHMDHIGGLLSHGL KERLRPDLRIHVASAEANFWESPDFSHTEMPAPVPPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVAR TGGHTPGHSVVRLASGEDRLTFAGDAVFAPGFDNPQWHNGFEHDPEESVRVRVELLRELAATGESLVATH LPFPSVCHVAAAGDAFRCVPAVWDY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3427 | - | - | 100% (305) | metal dependent hydrolase |
| M. smegmatis MC2 155 | MSMEG_0610 | - | 3e-21 | 28.33% (293) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_6679 | - | 5e-15 | 29.03% (248) | metallo-beta-lactamase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 3e-08 | 26.90% (197) | hypothetical protein Mb2322c |
| M. gilvum PYR-GCK | Mflv_1675 | - | 3e-09 | 28.34% (187) | beta-lactamase domain-containing protein |
| M. tuberculosis H37Rv | Rv2300c | - | 3e-08 | 26.90% (197) | hypothetical protein Rv2300c |
| M. leprae Br4923 | MLBr_01912 | - | 3e-06 | 27.27% (231) | putative glyoxylase II |
| M. abscessus ATCC 19977 | MAB_4947 | - | 5e-10 | 28.17% (213) | Beta-lactamase-like protein |
| M. marinum M | MMAR_3523 | - | 3e-11 | 31.75% (189) | hypothetical protein MMAR_3523 |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_0195 | - | 1e-128 | 72.41% (290) | metal dependent hydrolase |
| M. ulcerans Agy99 | MUL_2742 | - | 8e-11 | 30.73% (192) | hypothetical protein MUL_2742 |
| M. vanbaalenii PYR-1 | Mvan_2949 | - | 1e-137 | 75.08% (301) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_0195|M.thermoresistible__bu ---------------------------MSTTAVRPVAHPEHDELVPSRYA
Mvan_2949|M.vanbaalenii_PYR-1 ---------------------------MSLDGISRLGGQSTDELVPSRYV
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
MMAR_3523|M.marinum_M --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4947|M.abscessus_ATCC_1997 -------------------------MFSAAVRTFTVGDATVTQLTELDVW
MLBr_01912|M.leprae_Br4923 --------------------------------------------------
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
Mvan_2949|M.vanbaalenii_PYR-1 QQVGEIEVTVICDGVLPITASTLATNADPAELAGWLDDMFLPPDVLDWPL
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMN--AFGIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMN--AFGIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
MMAR_3523|M.marinum_M MKVHHLNCGTMN--SPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMN--SPGAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
MAB_4947|M.abscessus_ATCC_1997 PIKPHHWYPALSEEQLVFARANYAPSAVSDDGSELIFAIHNYVIELADTI
MLBr_01912|M.leprae_Br4923 -----------------MSDSDRLYFRQLLSGRDFAVDDVVATQMRNFAY
.
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFPRAGRLAHRMQAAGIEPAAVTDVVL
Mvan_2949|M.vanbaalenii_PYR-1 NVVVVRTGGQTILVDAGLGVEFPDFPRAGQTVRRLEAAGIDPASVTDVVL
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVL
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHVVL
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHIVL
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFERTETAAEQLAHLGYRLSDVRHIIV
MAB_4947|M.abscessus_ATCC_1997 IVVDTCSGN-----HKNRPLFADLHMLNTDYLTRLEQSGYSPEAVDIVVN
MLBr_01912|M.leprae_Br4923 LIGDRQTG---------DCVVVDPAYAAGDLVDALEADGMR---LSGVLV
. . : * : ::
TH_0195|M.thermoresistible__bu THLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEAEFWAAPDFSRTAMPHPV
Mvan_2949|M.vanbaalenii_PYR-1 THLHMDHVGGLLTDGLKARLRPDLRIHLAAAEAEFWAAPDFSQTAMPQPV
MSMEG_3427|M.smegmatis_MC2_155 THLHMDHIGGLLSHGLKERLRPDLRIHVASAEANFWESPDFSHTEMPAPV
Mb2322c|M.bovis_AF2122/97 THFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGP
Rv2300c|M.tuberculosis_H37Rv THFDFDHIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGP
MMAR_3523|M.marinum_M THFDFDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGP
MUL_2742|M.ulcerans_Agy99 THFDSDHIGGLADFPDAQVHVTSAEARGAIHAPSFRERVRYRSVQWAHGP
Mflv_1675|M.gilvum_PYR-GCK THFDADHIGGLADFPDAQVHVTAQEVLSAMKSPSVQNRIRFQPSQWAHGP
MAB_4947|M.abscessus_ATCC_1997 THLHLDHCG----WNTRLVEGTWRPTFPAATYLFHHTELKYIRAQWESAP
MLBr_01912|M.leprae_Br4923 THHHPDHVGGVMMGFQLKGLTELLERVTVPVHVNTHEALWISRVTGIDIG
** . ** * .
TH_0195|M.thermoresistible__bu PDVLRAVASRFLDVYRDRLRPFDTQYEVAPGVSVHRTG----------GH
Mvan_2949|M.vanbaalenii_PYR-1 PDVLRSVATRFLDEYHGRLRPFETEYEVAPGVLISRTG----------GH
MSMEG_3427|M.smegmatis_MC2_155 PPALRAIAGRFLDEYRGQIQTFDSEYDITPGVHVARTG----------GH
Mb2322c|M.bovis_AF2122/97 KLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----------GH
Rv2300c|M.tuberculosis_H37Rv KLVEHGPDG---EPWRG-FASAKPLDSIGTGVVLVPMP----------GH
MMAR_3523|M.marinum_M KLVEHGHDG---ESWRG-FAAAKPLDAIADGVVLVPMP----------GH
MUL_2742|M.ulcerans_Agy99 KLVEHGHDG---ESSPG-FAAAKTLDAIADGVVLVPMP----------GH
Mflv_1675|M.gilvum_PYR-GCK RIVEHTADG---EPWRG-FAAAKELSEIGPGFALVPLP----------GH
MAB_4947|M.abscessus_ATCC_1997 IDQWQDNGGWVYEDSILPVLEHAPYGFVKSGQVLHSYGSTHIRALDAGGH
MLBr_01912|M.leprae_Br4923 HLTTHEHRD--------------KLSVGDIEIELLHTP----------GH
: : **
TH_0195|M.thermoresistible__bu TPGHSIVRLESGKDRLTFAGDAVFQVGFDN----PQWHNGFEHDPEEAAR
Mvan_2949|M.vanbaalenii_PYR-1 TPGHSIVRVASGGEALTFAGDAVFAPGFDN----PEWHNGFEHDPEEAAR
MSMEG_3427|M.smegmatis_MC2_155 TPGHSVVRLASGEDRLTFAGDAVFAPGFDN----PQWHNGFEHDPEESVR
Mb2322c|M.bovis_AF2122/97 TRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSY
Rv2300c|M.tuberculosis_H37Rv TRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMRAEEKLLSY
MMAR_3523|M.marinum_M TRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSF
MUL_2742|M.ulcerans_Agy99 TRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLRSQEELFSF
Mflv_1675|M.gilvum_PYR-GCK TEGHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPMPASLRAFEMAVAA
MAB_4947|M.abscessus_ATCC_1997 TPGHVAIEVRAADTGLLIAGDALHHPMQAQF---PDLPFYADADPAQAVA
MLBr_01912|M.leprae_Br4923 TPGSQCFLLDG----LLVAGDTLFLEGCGRT----DFPGGNSDEMYRSLQ
* * . : . : .**:..
TH_0195|M.thermoresistible__bu VRVRLLQEIAASGETLVATHLPFPSLCRVAPRGEAFRFVPTVWDH----
Mvan_2949|M.vanbaalenii_PYR-1 VRVRLLRELAATGEALVATHLPFPSVCRVATAGDVFRCVPSVWDY----
MSMEG_3427|M.smegmatis_MC2_155 VRVELLRELAATGESLVATHLPFPSVCHVAAAGDAFRCVPAVWDY----
Mb2322c|M.bovis_AF2122/97 NRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDTA------
Rv2300c|M.tuberculosis_H37Rv NRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDTA------
MMAR_3523|M.marinum_M DRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYALAKDLS------
MUL_2742|M.ulcerans_Agy99 DRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYAVAKDLS------
Mflv_1675|M.gilvum_PYR-GCK DRKMVLDNHSRLTELYRRQDPDLLIVCSHDR--KLYEHAKATAGD----
MAB_4947|M.abscessus_ATCC_1997 TRRALLGRCADENLKLLTAHFPAHSPLGVRRSGAAFTWDGSRAID----
MLBr_01912|M.leprae_Br4923 QLAQLPGNPTVFPGHWYSTAPSATLSMVKCSNYVYRAADLNQWRMLMDS
: . :