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VATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPPVKVHHLNCGTMNAFGIALLCH VLLVETDDGLVLVDTGFGIQDCLDPGRVGLFRHVLRPAFLQAETAARQIEQLGYRTSDVRHIVLTHFDFD HIGGIADFPEAHLHVTAAEARGAIHAPSLRERLRYRRGQWAHGPKLVEHGPDGEPWRGFASAKPLDSIGT GVVLVPMPGHTRGHAAVAVDAGHRWVLHCGDAFYHRGTLDGRFRVPFVMRAEEKLLSYNRNQLRDNQARI VELHRRHDPDLLIVCAHDPDLYQLARDTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2300c | - | - | 100% (310) | hypothetical protein Rv2300c |
| M. tuberculosis H37Rv | Rv0406c | - | 2e-08 | 32.09% (187) | beta lactamase like protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2322c | - | 0.0 | 100.00% (310) | hypothetical protein Mb2322c |
| M. gilvum PYR-GCK | Mflv_1675 | - | 6e-89 | 57.74% (265) | beta-lactamase domain-containing protein |
| M. leprae Br4923 | MLBr_00270 | - | 5e-08 | 29.51% (183) | hypothetical protein MLBr_00270 |
| M. abscessus ATCC 19977 | MAB_4947 | - | 5e-09 | 26.48% (253) | Beta-lactamase-like protein |
| M. marinum M | MMAR_3523 | - | 1e-123 | 78.29% (258) | hypothetical protein MMAR_3523 |
| M. avium 104 | MAV_4762 | - | 1e-06 | 29.51% (183) | metallo-beta-lactamase superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3427 | - | 4e-08 | 26.90% (197) | metal dependent hydrolase |
| M. thermoresistible (build 8) | TH_0195 | - | 5e-08 | 25.38% (197) | metal dependent hydrolase |
| M. ulcerans Agy99 | MUL_2742 | - | 1e-117 | 75.97% (258) | hypothetical protein MUL_2742 |
| M. vanbaalenii PYR-1 | Mvan_5078 | - | 4e-92 | 60.69% (262) | beta-lactamase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2300c|M.tuberculosis_H37Rv MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
Mb2322c|M.bovis_AF2122/97 MVATRGRPCPTNFSRPQRPRVAGNGTKSQRCRGRLTTSMLGVAPEAKGPP
MMAR_3523|M.marinum_M --------------------------------------------------
MUL_2742|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1675|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5078|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3427|M.smegmatis_MC2_155 --------------------------MTTTDNTAHAGTQTIDELVPSRYA
TH_0195|M.thermoresistible__bu --------------------------MSTTAVRPVA-HPEHDELVPSRYA
MLBr_00270|M.leprae_Br4923 --------------------------------------------------
MAV_4762|M.avium_104 --------------------------------------------------
MAB_4947|M.abscessus_ATCC_1997 ------------------------MFSAAVRTFTVGDATVTQLTELDVWP
Rv2300c|M.tuberculosis_H37Rv VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
Mb2322c|M.bovis_AF2122/97 VKVHHLNCGTMNAF--GIALLCHVLLVETDDGLVLVDTGFGIQDCLD-PG
MMAR_3523|M.marinum_M MKVHHLNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-PR
MUL_2742|M.ulcerans_Agy99 MKVHHHNCGTMNSP--GAALLCHVLLVEAGNGLVLVDTGFGVQDCLD-QR
Mflv_1675|M.gilvum_PYR-GCK MKVRHLNCGTIRPVKVPVPMVCHVLLVESDAGLVLVDSGFGTRDCAH-PE
Mvan_5078|M.vanbaalenii_PYR-1 MKVHHLNCGTIRPTGVGT-MVCHVLLVESADGLVLVDTGFGTHDCED-PN
MSMEG_3427|M.smegmatis_MC2_155 VQVGDIEVLVISDGVLPITASTMATNADSDTYRTWLSDRFLPQDILDWPL
TH_0195|M.thermoresistible__bu LRVGDIEVLVISDGVLPLPAATLATNADRAELAAWLHDMFLPADLFDWPL
MLBr_00270|M.leprae_Br4923 -MAAATLFQVTDSVHFARGDAVNWALVADDTGVMLIDTGY-PGDRDD---
MAV_4762|M.avium_104 ---MAELVQVTDAVHLARGDAVNWTLVADDTGVMLVDAGY-PGDRED---
MAB_4947|M.abscessus_ATCC_1997 IKPHHWYPALSEEQLVFARANYAPSAVSDDGSELIFAIHNYVIELADTII
. . : .
Rv2300c|M.tuberculosis_H37Rv RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
Mb2322c|M.bovis_AF2122/97 RVGLFR------------HVLRPAFLQAETAARQIEQLGYRTSDVRHIVL
MMAR_3523|M.marinum_M RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHVVL
MUL_2742|M.ulcerans_Agy99 RLGAFR------------HFLRPALLQNETAVHQIERLGYRPSDVRHIVL
Mflv_1675|M.gilvum_PYR-GCK EFGRIRR-----------RIIRPDFERTETAAEQLAHLGYRLSDVRHIIV
Mvan_5078|M.vanbaalenii_PYR-1 RFGRIRS-----------RFIRPNFDRGETALNQIRQLGFRRSDVRHVVV
MSMEG_3427|M.smegmatis_MC2_155 NVVVVRSGDRTILVDAGLGVEFPDFPRAGRTVARLEAAGIDPSAVTDVVL
TH_0195|M.thermoresistible__bu NVAVVRSGDRTILIDSGLGLEFPEFPRAGRLAHRMQAAGIEPAAVTDVVL
MLBr_00270|M.leprae_Br4923 ------------------------------VVASLRQLGYEAGDVRAILL
MAV_4762|M.avium_104 ------------------------------VLGSLAELGYGPGDVRAIVL
MAB_4947|M.abscessus_ATCC_1997 VVDTCSG------NHKNRPLFADLHMLNTDYLTRLEQSGYSPEAVDIVVN
: * * ::
Rv2300c|M.tuberculosis_H37Rv THFDFDHIGGIADFPEAHLHVTAAEARGAIHAP--------SLRERLRYR
Mb2322c|M.bovis_AF2122/97 THFDFDHIGGIADFPEAHLHVTAAEARGAIHAP--------SLRERLRYR
MMAR_3523|M.marinum_M THFDFDHIGGLADFPDAQVHVTSAEARGAIHAP--------SFRERVRYR
MUL_2742|M.ulcerans_Agy99 THFDSDHIGGLADFPDAQVHVTSAEARGAIHAP--------SFRERVRYR
Mflv_1675|M.gilvum_PYR-GCK THFDADHIGGLADFPDAQVHVTAQEVLSAMKSP--------SVQNRIRFQ
Mvan_5078|M.vanbaalenii_PYR-1 THFDADHIGGLADFPDALVHVTTTEAFGAMRSP--------SIQERIRFR
MSMEG_3427|M.smegmatis_MC2_155 THLHMDHIGGLLSHGLKERLRPDLRIHVASAEA--------NFWESPDFS
TH_0195|M.thermoresistible__bu THLHMDHVGGLLTDGLMGRLRPDLRVHLAAAEA--------EFWAAPDFS
MLBr_00270|M.leprae_Br4923 THAHIDHMGSAIWFASKHRTPVYCHADEVGHTKREYLEQVSLLNIAMRVW
MAV_4762|M.avium_104 THAHIDHLGTAIWLASEHGIPVYCHADEVGHAKREYLEQVSIVDVALRIW
MAB_4947|M.abscessus_ATCC_1997 THLHLDHCGWNTRLVEGTWRPTFPAATYLFHHT------------ELKYI
** . ** *
Rv2300c|M.tuberculosis_H37Rv RGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTG----------V
Mb2322c|M.bovis_AF2122/97 RGQWAHGPKLVEHGPDG---EPWRG-FASAKPLDSIGTG----------V
MMAR_3523|M.marinum_M SVQWAHGPKLVEHGHDG---ESWRG-FAAAKPLDAIADG----------V
MUL_2742|M.ulcerans_Agy99 SVQWAHGPKLVEHGHDG---ESSPG-FAAAKTLDAIADG----------V
Mflv_1675|M.gilvum_PYR-GCK PSQWAHGPRIVEHTADG---EPWRG-FAAAKELSEIGPG----------F
Mvan_5078|M.vanbaalenii_PYR-1 PPQWAHGPRIVEHDIDG---EAWRG-FAAAKELTQIGPG----------F
MSMEG_3427|M.smegmatis_MC2_155 HTEMPAPVPPALRAIAGRFLDEYRGQIQTFDSEYDITPG----------V
TH_0195|M.thermoresistible__bu RTAMPHPVPDVLRAVASRFLDVYRDRLRPFDTQYEVAPG----------V
MLBr_00270|M.leprae_Br4923 QPRWAIWSGHVLRSGGLIRGGIPTAQPLTAETAAGLPGH----------P
MAV_4762|M.avium_104 RPRWAKWTAHVVRSGGLIRDGIPTAQPLTAEVAAGLPGR----------P
MAB_4947|M.abscessus_ATCC_1997 RAQWESAPIDQWQDNGGWVYEDSILPVLEHAPYGFVKSGQVLHSYGSTHI
: :
Rv2300c|M.tuberculosis_H37Rv VLVPMPGHTRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMR
Mb2322c|M.bovis_AF2122/97 VLVPMPGHTRGHAAVAVDAGHRWVLHCGDAFYHRGTLDG--RFRVPFVMR
MMAR_3523|M.marinum_M VLVPMPGHTRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLR
MUL_2742|M.ulcerans_Agy99 VLVPMPGHTRGHAAVAVDAGDRWILHCGDAFYHVGTLDG--QSKVPFVLR
Mflv_1675|M.gilvum_PYR-GCK ALVPLPGHTEGHACVAVDAGHRWLLHAGDAFYHHSEIDGGGPPPMPASLR
Mvan_5078|M.vanbaalenii_PYR-1 VLVSLPGHTRGHACVAVDAGHRWLLHAGDSFYHPGTLAG--APPVPKWTA
MSMEG_3427|M.smegmatis_MC2_155 HVARTGGHTPGHSVVRLASGEDRLTFAGDAVFAPGFDN----PQWHNGFE
TH_0195|M.thermoresistible__bu SVHRTGGHTPGHSIVRLESGKDRLTFAGDAVFQVGFDN----PQWHNGFE
MLBr_00270|M.leprae_Br4923 MAIFTPGHTGGHCSYVVDG----VLISGDALITGHPLLR------HRGPQ
MAV_4762|M.avium_104 TPVFSPGHTNGHCSYLIDG----VLVSGDALITGHPLLR------HRGPQ
MAB_4947|M.abscessus_ATCC_1997 RALDAGGHTPGHVAIEVRAADTGLLIAGDALHHPMQAQF---PDLPFYAD
*** ** : . : .**:.
Rv2300c|M.tuberculosis_H37Rv AEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDT
Mb2322c|M.bovis_AF2122/97 AEEKLLSYNRNQLRDNQARIVELHRRHDPDLLIVCAHDP--DLYQLARDT
MMAR_3523|M.marinum_M SQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYALAKDL
MUL_2742|M.ulcerans_Agy99 SQEELFSFDRRQLRDNQARLAELQRRQDPGLLIICAHDP--SLYAVAKDL
Mflv_1675|M.gilvum_PYR-GCK AFEMAVAADRKMVLDNHSRLTELYRRQDPDLLIVCSHDR--KLYEHAKAT
Mvan_5078|M.vanbaalenii_PYR-1 RLEMLVASDKQKVKQNHVRLAELYRRQDPDLMILCSHDV--TLYEQARAT
MSMEG_3427|M.smegmatis_MC2_155 HDPEESVRVRVELLRELAATGESLVATHLPFPSVCHVAAAGDAFRCVPAV
TH_0195|M.thermoresistible__bu HDPEEAARVRVRLLQEIAASGETLVATHLPFPSLCRVAPRGEAFRFVPTV
MLBr_00270|M.leprae_Br4923 LLTAVFSHSQKQCLRSLDALGLLETRILAPGHGELWHGPIREATEAALKQ
MAV_4762|M.avium_104 LLPAIFSYSQRDCIRTLSALALLDTEVLLPGHGDVWRGPIKEATDAALAL
MAB_4947|M.abscessus_ATCC_1997 ADPAQAVATRRALLGRCADENLKLLTAHFPAHSPLGVRRSGAAFTWDGSR
:
Rv2300c|M.tuberculosis_H37Rv A-----
Mb2322c|M.bovis_AF2122/97 A-----
MMAR_3523|M.marinum_M S-----
MUL_2742|M.ulcerans_Agy99 S-----
Mflv_1675|M.gilvum_PYR-GCK AGD---
Mvan_5078|M.vanbaalenii_PYR-1 AQT---
MSMEG_3427|M.smegmatis_MC2_155 WDY---
TH_0195|M.thermoresistible__bu WDH---
MLBr_00270|M.leprae_Br4923 AGALTR
MAV_4762|M.avium_104 ATGR--
MAB_4947|M.abscessus_ATCC_1997 AID---