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TSLQGKVVFITGAARGIGAEVARRLHNKGAKLVLTDLSKSELAVMGAELGGDDRLLTVVADVRDLPAMQA AAETAVERFGGIDVVVANAGIASYGSVLKVDPQAFRRVLDVNLLGNFHTVRATLPALIDRRGYVLIVSSL AAFAAPPGMAPYNMSKAGNEHFANALRLEVAHLGVSVGSAHMSWIDTALVRDTKADLPAFAELLARLPWP LNKTTSVNKCAAAFVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIRNTVAKLMPQMDAEVAALGR FASAYTESLENS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2129c | - | - | 100% (293) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0687 | fabG | 2e-26 | 34.10% (217) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. tuberculosis H37Rv | Rv2750 | - | 3e-25 | 32.52% (246) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2153c | - | 1e-164 | 100.00% (293) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3050 | - | 1e-109 | 67.24% (290) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 2e-24 | 35.38% (195) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2117 | - | 4e-97 | 62.59% (278) | short chain dehydrogenase |
| M. marinum M | MMAR_3109 | - | 1e-132 | 80.07% (291) | dehydrogenase |
| M. avium 104 | MAV_2376 | - | 1e-117 | 74.39% (285) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4188 | - | 1e-108 | 68.17% (289) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_2769 | - | 1e-113 | 73.93% (280) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2359 | - | 1e-131 | 79.38% (291) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3477 | - | 1e-109 | 67.01% (291) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3109|M.marinum_M --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_2376|M.avium_104 --------------------------------------------------
TH_2769|M.thermoresistible__bu --------------------------------------------------
Mflv_3050|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3477|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4188|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3109|M.marinum_M --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_2376|M.avium_104 --------------------------------------------------
TH_2769|M.thermoresistible__bu --------------------------------------------------
Mflv_3050|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3477|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4188|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3109|M.marinum_M --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_2376|M.avium_104 --------------------------------------------------
TH_2769|M.thermoresistible__bu --------------------------------------------------
Mflv_3050|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3477|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4188|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3109|M.marinum_M --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_2376|M.avium_104 --------------------------------------------------
TH_2769|M.thermoresistible__bu --------------------------------------------------
Mflv_3050|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3477|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4188|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3109|M.marinum_M --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_2376|M.avium_104 --------------------------------------------------
TH_2769|M.thermoresistible__bu --------------------------------------------------
Mflv_3050|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3477|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4188|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
Rv2129c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2153c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3109|M.marinum_M --------------------------------------------------
MUL_2359|M.ulcerans_Agy99 --------------------------------------------------
MAV_2376|M.avium_104 --------------------------------------------------
TH_2769|M.thermoresistible__bu --------------------------------------------------
Mflv_3050|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3477|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4188|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2117|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
Rv2129c|M.tuberculosis_H37Rv ----------------------MTSLQGKVVFITGAARGIGAEVARRLHN
Mb2153c|M.bovis_AF2122/97 ----------------------MTSLQGKVVFITGAARGIGAEVARRLHN
MMAR_3109|M.marinum_M ----------------------MTSVQDKVVFITGGARGIGAEVARRLHN
MUL_2359|M.ulcerans_Agy99 ----------------------MTSVQDKVVFITGGARGIGAEVARRLHN
MAV_2376|M.avium_104 ----------------------MTSLRDKVVFITGGARGIGAEVARRLNA
TH_2769|M.thermoresistible__bu -------------------------VTGKVVFITGGAAGIGAEVARRLHA
Mflv_3050|M.gilvum_PYR-GCK -------------------MAAAGSIDGKTVFITGGARGVGEEVARRLHA
Mvan_3477|M.vanbaalenii_PYR-1 ----------------------MGAVAGKTVFITGGARGVGAEVARRLHA
MSMEG_4188|M.smegmatis_MC2_155 ------------------MGSRTASLGGKVVFITGGGAGVGAEVSRRLYR
MAB_2117|M.abscessus_ATCC_1997 ------------------MGSTANGVAGKTVMITGGAGGIGVEVAHRLYA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. .. * :**.. *:* *.: *
Rv2129c|M.tuberculosis_H37Rv KGAKLVLTDLSKSELAVMGAELGG-DDRLLTVVADVRDLPAMQAAAETAV
Mb2153c|M.bovis_AF2122/97 KGAKLVLTDLSKSELAVMGAELGG-DDRLLTVVADVRDLPAMQAAAETAV
MMAR_3109|M.marinum_M MGAKLVLADLSEAELATIAAELGG-DDRVLTVVADVRDLPAMEAAADQAV
MUL_2359|M.ulcerans_Agy99 MGAKLVLTDLSEAELATIAAELGR-DDRVLTVVADVRDLPAMEAAADQAV
MAV_2376|M.avium_104 KGARLVLTDLNDAELTSLAAELG--EERVLTAVADVRDLSAMQAAADRAV
TH_2769|M.thermoresistible__bu RGAKVVLTDVDEVALRGMLSELG--ADRVLTRVADVRDLTAMQAAADAAV
Mflv_3050|M.gilvum_PYR-GCK RGARLVLTDLDEPPLAALRDRLG--AERVHTVTADVRDLSAMEAAAAGAI
Mvan_3477|M.vanbaalenii_PYR-1 KGARLVLTDLDEAPLTELRDSLG--PDRVHTIVADVRELTAMEAAAASAV
MSMEG_4188|M.smegmatis_MC2_155 KGAKLMLVDVDADALKAHADTLG---EDVATAVADVRDLAAMKAAADAAV
MAB_2117|M.abscessus_ATCC_1997 KGANVVLTDLDEAKLAAIADELG--GDRVLVAVADVCDLTAMEKVAAQAV
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
**.::: *:. : . . ** : .*:: * .
Rv2129c|M.tuberculosis_H37Rv ERFGGIDVVVANAGIASYGSVLKVDPQAFRRVLDVNLLGNFHTVRATLPA
Mb2153c|M.bovis_AF2122/97 ERFGGIDVVVANAGIASYGSVLKVDPQAFRRVLDVNLLGNFHTVRATLPA
MMAR_3109|M.marinum_M EKFGGIDIVMANAGIASYGSVLQVDPEAFKRVLDVNVMGVFHTVRATLPA
MUL_2359|M.ulcerans_Agy99 EKFGGIDIVMANAGIASYGSVLQVDPEAFKRVLDVNVMGVFHTVRATLPA
MAV_2376|M.avium_104 ERFGGIDVVLANAGIASYGSVAQVDPDAFRRVLDINVLGVFHTVRATLPA
TH_2769|M.thermoresistible__bu ERFGGIDVTVANAGVATYGSVLAVDPAAFKLLIDVNVTGVFHTVRATLPA
Mflv_3050|M.gilvum_PYR-GCK DRFGGIDVVMANAGIASYGSVLQVDPQAFRTLMDVNVLGVFHTVRATLPS
Mvan_3477|M.vanbaalenii_PYR-1 DRFGGIDIVMANAGIATYGSVLQVDPEAFRTLMDVNVMGVFHTVRATLPS
MSMEG_4188|M.smegmatis_MC2_155 ERFGGIDVVVANAGVASYGSVQQVDPEAFKRLLDINVLGVFHTVRATLPS
MAB_2117|M.abscessus_ATCC_1997 QRFGGIDVVVANAGLLTFGSVLQIDPATFKKLIDVNVLGVFHTVRAALPS
MLBr_00862|M.leprae_Br4923 AKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQR
:.* *:.: ***: * . * * :: :*: * .: **
Rv2129c|M.tuberculosis_H37Rv LIDR--RGYVLIVSSLAAFAAPPGMAPYNMSKAGNEHFANALRLEVAHLG
Mb2153c|M.bovis_AF2122/97 LIDR--RGYVLIVSSLAAFAAPPGMAPYNMSKAGNEHFANALRLEVAHLG
MMAR_3109|M.marinum_M VIER--RGYVLIVSSLAAYAASPGLAPYNASKAAVEIFANALRLEVADRG
MUL_2359|M.ulcerans_Agy99 VIER--RGYVLIVSSLAAYAASPGLAPYNASKAAVEIFANALRLEVADRG
MAV_2376|M.avium_104 VIER--RGYVLIVSSLAAYAACPGLAPYNASKAGVEMLANALRLEVARHG
TH_2769|M.thermoresistible__bu LIDR--RGYVLIVSSLAAFAAAPGMAPYDAAKAGVEHFANALRMEVAHQG
Mflv_3050|M.gilvum_PYR-GCK VLER--RGYVLIVSSLAAYAAAPGLAPYNATKAAVEHFANALRLEVGYRG
Mvan_3477|M.vanbaalenii_PYR-1 VLER--RGYVLIVSSLAAYAAAPGLAPYNAAKAAVEHFANALRLEVGFRG
MSMEG_4188|M.smegmatis_MC2_155 VIER--RGYVLIVSSLAAYAASPGLAPYNASKAAVEQFANALRLEVAHRG
MAB_2117|M.abscessus_ATCC_1997 VIER--RGYVLVVSSLAAYAASPAVTAYNASKAAVEHFANALRLEVAHRG
MLBr_00862|M.leprae_Br4923 LVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVG
:::* *::: ***:**:*. .::.* :**. :::.** *: *
Rv2129c|M.tuberculosis_H37Rv VSVGSAHMSWIDTALVRDTKADLPAFAELLAR-LPWPLNKTTSVNKCAAA
Mb2153c|M.bovis_AF2122/97 VSVGSAHMSWIDTALVRDTKADLPAFAELLAR-LPWPLNKTTSVNKCAAA
MMAR_3109|M.marinum_M VSVGSAHMSWIDTALVRDTKGDLPAFAELLSR-LPWPLNKTTSVNKCAAA
MUL_2359|M.ulcerans_Agy99 VSVGSAHMSWIDTALVRDTKGDLPAFAELLSR-LPWPLNKTTSVNKCAAA
MAV_2376|M.avium_104 VKVGSAHMSWINTALVRDTQNDLPAFDRLLAS-LPWPLNKTTTVDKCAAA
TH_2769|M.thermoresistible__bu VDVGSAHMSWIDTAMVRDTKDDLPSFREMLTS-LPGPLGRTTSVDKCADA
Mflv_3050|M.gilvum_PYR-GCK VDVGSAHMSWIDTPLVRDTRADLPTFTEMISR-LPFPLNRTTSVEACGAA
Mvan_3477|M.vanbaalenii_PYR-1 VAVGSAHMSWIDTPLVRDTKADLPTFAEMLSR-LPFPLNQTTSVEACGEA
MSMEG_4188|M.smegmatis_MC2_155 VDVGSAHMSWIDTAMVNDSKADLSTFGEMLSK-LPPPLSSTTSVSACGEA
MAB_2117|M.abscessus_ATCC_1997 VDVGSAHMSWIDTSMVNDQKSNLSAFSEMLTR-LPPPLRTVTSVQACGRA
MLBr_00862|M.leprae_Br4923 VGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPD
* : : . *:* ::.. : : .: . * : .
Rv2129c|M.tuberculosis_H37Rv FVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIRNTVAKLMPQMDA
Mb2153c|M.bovis_AF2122/97 FVNGIEGRKDRVYCPGWVALFRWLKPLLSTRVGQRPIRNTVAKLMPQMDA
MMAR_3109|M.marinum_M FVKGIEGRKTRIYCPDWVGLFRWLKPVLSTPLGELPVRKATAELLPKMDA
MUL_2359|M.ulcerans_Agy99 FIKGIEGRKTRIYCPDWVGLFRWLKPALSTPLGELPVRKATAELLPKMDA
MAV_2376|M.avium_104 FVKGIQRRRTRIYCPRWVALFRWAKPVLSSRLGEMPLHSPTAELLPALDA
TH_2769|M.thermoresistible__bu FVKGIERRSSRIYCPQWVGLVRWLKPVLSTRLGQAPILRTAPRLVPQMDA
Mflv_3050|M.gilvum_PYR-GCK FVSGIEKRNRQINSPGWVGLMRWLKPVLSTPIGETPVLKFVPDLLPRMDA
Mvan_3477|M.vanbaalenii_PYR-1 FVTGIEQRKRQINCPGWVGVLRWLKSLLSTPIGEQQVLKFVPDLLPRMDA
MSMEG_4188|M.smegmatis_MC2_155 FVKGIERRARRINCPGWVEAFRWLKPILSTRLGELPVLRFVPDLLPRMDA
MAB_2117|M.abscessus_ATCC_1997 FVKGIERRSRRINCPGWVGITRWLKPVLSTRLGEIPVRGMIPEILPRIDA
MLBr_00862|M.leprae_Br4923 KVADTILSAIKKNKP--------IRPVAPEAYALYGISRVLPQVL-RSTA
: . : * :. . . : . :: *
Rv2129c|M.tuberculosis_H37Rv EVAALGRFASAYTESLENS-------
Mb2153c|M.bovis_AF2122/97 EVAALGRFASAYTESLENS-------
MMAR_3109|M.marinum_M EVAALGRSTSAYNQGLEKP-------
MUL_2359|M.ulcerans_Agy99 EMAALGRATSAYNQGLEKP-------
MAV_2376|M.avium_104 QVAALGRSMSAANVELLRPDRGSARN
TH_2769|M.thermoresistible__bu EVAELGRSVSARVAAVRTDDPDSADG
Mflv_3050|M.gilvum_PYR-GCK EVAALGRSMGTRTKDLEDR-------
Mvan_3477|M.vanbaalenii_PYR-1 EVAALGRSMGTRTQRLEER-------
MSMEG_4188|M.smegmatis_MC2_155 EVAALGRSSSAHTESIEKR-------
MAB_2117|M.abscessus_ATCC_1997 EVAELQR---AARDAIERP-------
MLBr_00862|M.leprae_Br4923 RIRVI---------------------
.: :