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MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPS SPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVS VPIGEQLMAKLLGVEPKTVHELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTI AQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNP ATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASA YSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3121 | cyp141 | - | 100% (400) | PROBABLE CYTOCHROME P450 141 CYP141 |
| M. tuberculosis H37Rv | Rv3518c | cyp142 | 2e-31 | 27.36% (296) | cytochrome P450 monooxygenase 142 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 3e-31 | 27.43% (401) | cytochrome P450 124 CYP124 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3144 | cysA3 | 4e-34 | 97.01% (67) | thiosulfate sulfurtransferase CysA3 |
| M. gilvum PYR-GCK | Mflv_0225 | - | 7e-47 | 32.06% (393) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-33 | 27.91% (301) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 5e-34 | 27.04% (392) | cytochrome P450 |
| M. marinum M | MMAR_3969 | cyp269A1 | 8e-50 | 31.22% (394) | cytochrome P450 269A1 Cyp269A1 |
| M. avium 104 | MAV_1339 | - | 1e-44 | 30.56% (373) | cytochrome P450 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_0762 | - | 3e-46 | 31.97% (391) | cytochrome P450 FAS1 |
| M. thermoresistible (build 8) | TH_4319 | - | 3e-43 | 27.59% (406) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | 2e-40 | 29.95% (364) | cytochrome P450 108B4 Cyp108B4 |
| M. vanbaalenii PYR-1 | Mvan_0682 | - | 4e-45 | 33.08% (396) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3825|M.abscessus_ATCC_1997 -----------------------MATALSEIEEAGRVLADPAAYADELRL
MUL_3863|M.ulcerans_Agy99 -------------------------MSAPTMDEAA-LLADPLAYTDETRL
MAV_1339|M.avium_104 ------------------------MQTHPPLRSPSFPLHSPDFYAGNP--
Mflv_0225|M.gilvum_PYR-GCK -----------------------MSQATGEAAPDLPPLHMRRDG---FDP
Mvan_0682|M.vanbaalenii_PYR-1 -----------------------MSQAV---RPELPPVHMRRDG---FDP
MSMEG_0762|M.smegmatis_MC2_155 -----------------------MTQAQ-----ALPPLHIRRDA---FDP
TH_4319|M.thermoresistible__bu -----------------VNVSDTLTGTDADATAAIPEYPMERDGRCPFAP
MMAR_3969|M.marinum_M -----------------------MAYPETNTATDYPFTQPDALS-----A
Rv3121|M.tuberculosis_H37Rv -------------------------------MTSTSIPTFPFDRPVPTEP
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
Mb3144|M.bovis_AF2122/97 --------------------------------------------------
MAB_3825|M.abscessus_ATCC_1997 HAAMTLLRREQPVTKVITDDYRPFWAVTKHDDIMAVERDNALWINEPRPL
MUL_3863|M.ulcerans_Agy99 HAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDIERDNTLFTNWPRPV
MAV_1339|M.avium_104 YPAYRELRATAPVCWNDVTN---FWALLKYEDIRFVSSNPALFTSTRGIT
Mflv_0225|M.gilvum_PYR-GCK TPHLREIREREGVRSVTNAFGMQVYLFTRYDDIKTVLSDHSRFSNGRPPG
Mvan_0682|M.vanbaalenii_PYR-1 TPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPPG
MSMEG_0762|M.smegmatis_MC2_155 TPELGEIRAGEGVHVTVNPFGMQVYLVTRHEDVKTVLSDHERFSNSRPPG
TH_4319|M.thermoresistible__bu PPGVMELAAAKPLSRVRIWDGSTPWLVTGYETARALFADSRVSVDDRRPG
MMAR_3969|M.marinum_M PRDLGKLRQRCPVADVRFPSGDPAVVVTRYDDAKRVLDDPRVSRNMYRAD
Rv3121|M.tuberculosis_H37Rv SPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHP
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
Mb3144|M.bovis_AF2122/97 ---MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAG------
MAB_3825|M.abscessus_ATCC_1997 LMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAMRDM
MUL_3863|M.ulcerans_Agy99 LATVAGD---ELQAAAG--VRTLIHLDDPQHRVARAIGADWFRPKAMRAL
MAV_1339|M.avium_104 IP--------DPQLPNPVQQGSLIFTDPPRHRQLRKLINSGFTRRRVSVL
Mflv_0225|M.gilvum_PYR-GCK FVVPGAP-PVDEETQARARAGNLLGLDPPEHQRLRRMLTPEFTHRRMQRL
Mvan_0682|M.vanbaalenii_PYR-1 FVVPGAP-PIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRL
MSMEG_0762|M.smegmatis_MC2_155 FVLPGAP-QISAEEQASNRAGNLLGLDPPEHQRLRRMLTPEFTIRRIKRL
TH_4319|M.thermoresistible__bu FPHWNEM-MRS---TIYKRPRSVFTTDAEEHTKFRRMLSKPFTFKRVEGL
MMAR_3969|M.marinum_M AARLSTT-QLN----MLELEFVSTLVDPPNHTRIRRLFAKALRRGRIEEL
Rv3121|M.tuberculosis_H37Rv SSPPFVP--------FVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARM
MLBr_02088|M.leprae_Br4923 AIAAGAE-------PRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQAL
Mb3144|M.bovis_AF2122/97 ------------------------AIKLDWRTDLQDPVKRDFVDAQQFSK
. : : :
MAB_3825|M.abscessus_ATCC_1997 KLRTDELANRYVNKLLEAG---GSCDFAQDIAVHFPLYVIMSLLGIPESD
MUL_3863|M.ulcerans_Agy99 KVRVDELAKNYVDAMMAAG---PECDFVQQIAVNYPLYVIMSLLGLPEAD
MAV_1339|M.avium_104 EPKIREIVRGILDG-IERG---AVHEFAEQIAAPLPTRMIAELIGAPPDD
Mflv_0225|M.gilvum_PYR-GCK RPRIAEIVDTQIDALAAAG---RPADLVEHFALPIPSLVICELLGVPYAD
Mvan_0682|M.vanbaalenii_PYR-1 QPRIAEIVDAQLDALAAARDGEASADLVQHFALPIPSLVICELLGVPYAD
MSMEG_0762|M.smegmatis_MC2_155 EPRIVEIVDAHLDAMESAG---PPADIVADFALPIPSLVICELLGVPYED
TH_4319|M.thermoresistible__bu RPAIQKITDDHIDKILAGP---KPADLVTALALPVPSLVISEMLGVPYED
MMAR_3969|M.marinum_M RPRIVTIVDELLDAMLAGP---MPADAVDALARPLPRQIIGEMFGFPPGE
Rv3121|M.tuberculosis_H37Rv RPVVQQIVDNALDDLAAAEP---PVDFQEIVSVPIGEQLMAKLLGVEPKT
MLBr_02088|M.leprae_Br4923 EGDIAALVDSLLDKGAAAG----QFDVIADLAFPLAVAVICRLLGVPYED
Mb3144|M.bovis_AF2122/97 LLSERGIANEDTVILYGGN-----NNWFAAYAYWYFKLYGHEKVKLLDGG
:. : : .
MAB_3825|M.abscessus_ATCC_1997 FDRMLKLTQELFGGDDSEFQRG----TTPEEQLMALLDFFGYFSGLTASR
MUL_3863|M.ulcerans_Agy99 FPRMLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTTAR
MAV_1339|M.avium_104 WEQFRAWSDAATGTADPEIEL---------DPAVAAGQLYEYFQRLIAAR
Mflv_0225|M.gilvum_PYR-GCK RDDFQRRSARQLDLSIP----------IPERLELQR-EGREYMAALVAGA
Mvan_0682|M.vanbaalenii_PYR-1 RDDFQRRSARQLDLSIP----------IPERIELAR-EGRAYMGSLVAGA
MSMEG_0762|M.smegmatis_MC2_155 RTDFQQRSARQLDLSAP----------MPERLELQR-QGRAYMRGLVERS
TH_4319|M.thermoresistible__bu AEFFQEHANRGLDRYAK----------AEDNMSKGM-SLSQYLIKLVEAK
MMAR_3969|M.marinum_M GDRAQYWAERLFSLSLH----------TAEEMAAGQQEFAAFICELAEKR
Rv3121|M.tuberculosis_H37Rv VHELAAHVDAAMSVCEIG----------DEEVSRRWSALCTMVIDILHRK
MLBr_02088|M.leprae_Br4923 APEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCR
Mb3144|M.bovis_AF2122/97 RKKWELDGRPLSS---------------------------DPVSRPVTSY
.
MAB_3825|M.abscessus_ATCC_1997 RQHPTDDLASTIANARVDG-ELLSDVDTASYYTIIATAGHDTTSATIAGG
MUL_3863|M.ulcerans_Agy99 RAHPTADLASAIANARIDG-EPLSDIDTVSYYLIVATAGHDTTSATISGG
MAV_1339|M.avium_104 RARPRADLLSVLAEAEIDE-HRLTDEDLLNFAFLLLVAGNETTRNLIALG
Mflv_0225|M.gilvum_PYR-GCK RRHPGDDILG-MLIREHG--GELTDDELIGVASLLLLAGHETTSNMLALG
Mvan_0682|M.vanbaalenii_PYR-1 RTNPGDDILG-MLVREHG--AELTDDELVGIAGLLLLAGHETTSNMLALG
MSMEG_0762|M.smegmatis_MC2_155 RTRPGDDILG-MLVREHG--TELTDDELIGIAGLLLLAGHETTSNMLGLG
TH_4319|M.thermoresistible__bu MQNPAEDAVSDLAERVKA--GEIDVKEAAQLGTGLLIAGHETTANMIGLG
MMAR_3969|M.marinum_M RAEPTGDFFSDLVAVSDVDDGQLSHLELVYLAQALFAAGIDSTWVMISR-
Rv3121|M.tuberculosis_H37Rv LAEPGDDLLSTIAQANRQQ-STMTDEQVVGMLLTVVIGGVDTPIAVITNG
MLBr_02088|M.leprae_Br4923 RGTPGEDLISRLIELDESG-DQLTEEEIIATCGLLLVAGHETTVNLIANA
Mb3144|M.bovis_AF2122/97 TASPPDNTIR-----------AFRDEVLAAINVKNLIDVRSPDE---FSG
* : : ..
MAB_3825|M.abscessus_ATCC_1997 LEALLEHPDQLARLR--ENPGLMPLAVDEMIRWVTPVK-EFMRTATADTE
MUL_3863|M.ulcerans_Agy99 LHALIEHPDQLARLQ--ADPALMSLATEEMIRWVTPVK-QFMRTASSDTV
MAV_1339|M.avium_104 TLALIAHPDQYRLLV--EEPARIPLAVEEMLRWNSPVV-HMARTATADVE
Mflv_0225|M.gilvum_PYR-GCK VLALLRHPDQLAAIR--DDPAAVAPAVEELLRWLSIVQTSIPRITTTDVE
Mvan_0682|M.vanbaalenii_PYR-1 TLALLRHPEQLAAVR--EDPDAVAPAVEELLRWLSIVHTAIPRITTTDVE
MSMEG_0762|M.smegmatis_MC2_155 VLALLRHPDQLACVR--DDPDAVGPAIEELLRWLSIVSTALPRITTTDVE
TH_4319|M.thermoresistible__bu VLALLEHPEQADFLRSAEDPKAIATAIEELMRYLSIIQNGQRRVAVEDIE
MMAR_3969|M.marinum_M MIGLLLHKGCYGRLV--ADPKLIEPTVEEVLRYLPPSNLGALRYAVEDIE
Rv3121|M.tuberculosis_H37Rv LASLLHHRDQYERLV--EDPGRVARAVEEIVRFNPATEIEHLRVVTEDVV
MLBr_02088|M.leprae_Br4923 VLAMLRNPSQWKALS--SNPQRAPLVVEETLRYDPAIH-LIGRVAAKDMT
Mb3144|M.bovis_AF2122/97 KILAPAHLPQEQSQR----PGHIPGAINVPWSRAANEDGTFKSDEELAKL
: * . : .
MAB_3825|M.abscessus_ATCC_1997 IRGVPITEGESVLLSYPSGNRDEDIFT-DPFTFDIARDPNKHLAFGFGVH
MUL_3863|M.ulcerans_Agy99 VRGIPIAAGESVLLSYVSANRDEEVFD-QPFRFDIGREPNKHVAFGYGVH
MAV_1339|M.avium_104 IRGQRIRAGEVVVMLYGSANRDEDVFGPDSEEFDVTRHPNPHIAFGCGEH
Mflv_0225|M.gilvum_PYR-GCK IAGVAIPAGQLVFASLPAGNRDPEFIE-HPEVLDIGRGAPGHLAFGHGVH
Mvan_0682|M.vanbaalenii_PYR-1 IAGVSIPAGQLVFASLPSGNRDDEFIE-RPEVFDITRGAMGHLAFGHGVH
MSMEG_0762|M.smegmatis_MC2_155 LAGVTIPAGHLVFASLPAGNRDPEFID-DPDTLDIRRGAPGHLAFGHGVH
TH_4319|M.thermoresistible__bu IAGETIRAGEGIILDLAPANWDPATFP-EPDRLDLQRSDAPQLGFGYGRH
MMAR_3969|M.marinum_M LDDAVIPKGTTIAVSTTAANRDPRFFD-DPDEFLVDRSENRHVSFGHGRF
Rv3121|M.tuberculosis_H37Rv IAGTALSAGSPAFTSITSANRDSDQFL-DPDEFDVERNPNEHIAFGYGPH
MLBr_02088|M.leprae_Br4923 IGQTTLTEGDTMVLLLAAANRDPAVYS-RPDEFDPDRPSSRHLAFAVGSH
Mb3144|M.bovis_AF2122/97 YADAGLDNSKETIAYCRIGERSSHTWFVLRELLG---HQNVNIAFGYGPH
: . .: . : ::.*. * .
MAB_3825|M.abscessus_ATCC_1997 FCLGAALARMEVNSFFSALLPRLESIEVDG---NIERT-STIFVGGIKHL
MUL_3863|M.ulcerans_Agy99 FCMGAALARMEVASFFTELLPRLKSIELSG---DPQFT-ATTFVGGLKRL
MAV_1339|M.avium_104 SCVGAQLARLEATVFFEELLRRYPRIELVG---EVDRM-RATMVPGVKRM
Mflv_0225|M.gilvum_PYR-GCK HCLGAPLARMEMAIAFPALFRRFPSLEPAEDFADVAFR-SFHFIYGLKSL
Mvan_0682|M.vanbaalenii_PYR-1 HCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFR-SFHFIYGLKSL
MSMEG_0762|M.smegmatis_MC2_155 HCLGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWR-PFHFIYGLQSL
TH_4319|M.thermoresistible__bu QCVGMQLARAELQIVFPTLLRRIPTLKLATTIDEIPFK-HDRLAYGVYEL
MMAR_3969|M.marinum_M LCPGAWLARCEMQSLLRGLVTRVPTLELAADVNDLKVR-TGMMNEGMLSL
Rv3121|M.tuberculosis_H37Rv ACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKEL
MLBr_02088|M.leprae_Br4923 FCLGAALARLEATVTLSAISARFPQVQLAG---ELVYK-PNVAMRGMSAL
Mb3144|M.bovis_AF2122/97 ACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKEL
* . :* : : * : : *: :
MAB_3825|M.abscessus_ATCC_1997 PIRYTLR
MUL_3863|M.ulcerans_Agy99 PVSYSLM
MAV_1339|M.avium_104 PVRMGA-
Mflv_0225|M.gilvum_PYR-GCK EVSW---
Mvan_0682|M.vanbaalenii_PYR-1 EVTW---
MSMEG_0762|M.smegmatis_MC2_155 AVAW---
TH_4319|M.thermoresistible__bu PVTW---
MMAR_3969|M.marinum_M PVRW---
Rv3121|M.tuberculosis_H37Rv LVTWPT-
MLBr_02088|M.leprae_Br4923 PVQV---
Mb3144|M.bovis_AF2122/97 LVTWPT-
: