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SAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDIERDNTLFTNWP RPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALKVRVDELAKNYVDAMMAAGPEC DFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGSDDSEFKRGSTSEDQLPALLDMFGYFNAVTTA RRAHPTADLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPAL MSLATEEMIRWVTPVKQFMRTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVA FGYGVHFCMGAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3863 | cyp108B4 | - | 100% (410) | cytochrome P450 108B4 Cyp108B4 |
| M. ulcerans Agy99 | MUL_1282 | cyp124A1 | 2e-59 | 34.34% (399) | cytochrome P450 124A1, Cyp124A1 |
| M. ulcerans Agy99 | MUL_0491 | cyp126A3 | 1e-54 | 33.25% (394) | cytochrome P450 126A3 Cyp126A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 2e-59 | 33.58% (402) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_4325 | - | 1e-176 | 74.63% (410) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv2266 | cyp124 | 2e-59 | 33.58% (402) | cytochrome P450 124 CYP124 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-37 | 28.32% (339) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3825 | - | 1e-160 | 66.58% (404) | cytochrome P450 |
| M. marinum M | MMAR_3999 | cyp108B4 | 0.0 | 98.05% (410) | cytochrome P450 108B4 Cyp108B4 |
| M. avium 104 | MAV_1609 | - | 0.0 | 85.37% (410) | cytochrome P450 family protein |
| M. smegmatis MC2 155 | MSMEG_2257 | - | 1e-174 | 73.17% (410) | cytochrome P450-terp |
| M. thermoresistible (build 8) | TH_2733 | - | 1e-179 | 75.37% (410) | PUTATIVE cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_2021 | - | 1e-175 | 73.90% (410) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2289|M.bovis_AF2122/97 MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREA
Rv2266|M.tuberculosis_H37Rv MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFATLRREA
MUL_3863|M.ulcerans_Agy99 --MSAPTMDEAA-LLADPLAYTDETR------------LHAALTRLRAQA
MMAR_3999|M.marinum_M --MSAPTMDEAA-LLADPLAYTDETR------------LHAALTRLRAQA
MAV_1609|M.avium_104 --MSTTTMDEAAKLLADPMAYTDEQR------------LHAALTHLRANA
MSMEG_2257|M.smegmatis_MC2_155 --MTARTIDDAAKVFAMPSAYTDEAK------------FHEALTHLRVNA
TH_2733|M.thermoresistible__bu --MSTPIIDEAARVFATPKAYTDERA------------LHAALTHLRAHA
Mflv_4325|M.gilvum_PYR-GCK --MSVRVADEAGKVFADPTAYADEQR------------LHAAMTHLRANA
Mvan_2021|M.vanbaalenii_PYR-1 --MSVRIADEAARVFADPSAYADEAR------------LHAAMTHLRANA
MAB_3825|M.abscessus_ATCC_1997 MATALSEIEEAGRVLADPAAYADELR------------LHAAMTLLRREQ
MLBr_02088|M.leprae_Br4923 --MRTCVPTRTCVYAFIEYLSHNRPMG-----TNPPSLVEAQMLLLRLID
. : . : **
Mb2289|M.bovis_AF2122/97 P-------ISFWPTIELPGFVAG-NGHWALTKYDDVFYASRHPDIFSSYP
Rv2266|M.tuberculosis_H37Rv P-------ISFWPTIELPGFVAG-NGHWALTKYDDVFYASRHPDIFSSYP
MUL_3863|M.ulcerans_Agy99 P-------VALVDVPNYR-------RFWAITRHADVMDIERDNTLFTNWP
MMAR_3999|M.marinum_M P-------VALVDVPNYR-------RFWAITRHADVMDIERDNTLFTNWP
MAV_1609|M.avium_104 P-------VSWVEVPNYK-------PFWAITKHADVMDIERENMLFTNWP
MSMEG_2257|M.smegmatis_MC2_155 P-------VSWVDVPPYR-------PFWAITRYADIMAIERANDLFTNSP
TH_2733|M.thermoresistible__bu P-------VSWVEVDGYR-------PFWAITKHADIMAIERDNELFTNSP
Mflv_4325|M.gilvum_PYR-GCK P-------VSWVDVEGYN-------PFWAITKHADIMAIERDNTVFTNSP
Mvan_2021|M.vanbaalenii_PYR-1 P-------VSWVEVPGYN-------PFWAITKHADIMAVERDNLVFTNSP
MAB_3825|M.abscessus_ATCC_1997 P-------VTKVITDDYR-------PFWAVTKHDDIMAVERDNALWINEP
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRL
* ..: . * * .
Mb2289|M.bovis_AF2122/97 NITIN--------DQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV
Rv2266|M.tuberculosis_H37Rv NITIN--------DQTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVV
MUL_3863|M.ulcerans_Agy99 RPVLATVAGD---ELQAAAGVR--TLIHLDDPQHRVARAIGADWFRPKAM
MMAR_3999|M.marinum_M RPVLATVAGD---ELQAAAGVR--TLIHLDDPQHRVARAIGADWFRPKAM
MAV_1609|M.avium_104 RPVLTTAEGD---EMQAAAGVR--TLIHMDDPQHRVVRAIGSDWFRPKAM
MSMEG_2257|M.smegmatis_MC2_155 RPVLMTAEED---EQQAAVGIS--TLIHMDDPQHRVIRAIGADWFRPKAM
TH_2733|M.thermoresistible__bu RPVLITAEAD---ELQAGVGIR--TLIHLDDPEHRDLRAIGADWFRPKAM
Mflv_4325|M.gilvum_PYR-GCK RPVLTTAEGD---AQHASMGVS--TLIHMDDPQHRKVRAIGADWFRPKAM
Mvan_2021|M.vanbaalenii_PYR-1 RPVLTTAEGD---AQHEAMGIS--TLIHLDDPQHRKVRAIGADWFRPKAM
MAB_3825|M.abscessus_ATCC_1997 RPLLMNLEQEAELDKQAAMGIELKTLVHIDDPKHRVLRAIGADWFRPKAM
MLBr_02088|M.leprae_Br4923 KATLAQQAIA---AGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVV
. : ::: :* * * * : : * **.:
Mb2289|M.bovis_AF2122/97 ARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPK
Rv2266|M.tuberculosis_H37Rv ARIEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPK
MUL_3863|M.ulcerans_Agy99 RALKVRVDELAKNYVDAMMAAGPE--CDFVQQIAVNYPLYVIMSLLGLPE
MMAR_3999|M.marinum_M RALKVRVDELAKNYVDAMMAAGPE--CDFVQQIAVNYPLYVIMSLLGLPE
MAV_1609|M.avium_104 RALKVRVDELAKIYVDKMLAAGPE--CDFVQEVAVNYPLYVIMSLLGLPE
MSMEG_2257|M.smegmatis_MC2_155 RALKIRVDELAKIHVDKMVAAGGE--CDFVQEITVNYPLYVIMSLLGIPE
TH_2733|M.thermoresistible__bu RALKIRVDELARIHVDKMLELGPE--CDFVQEVAVNYPLYVIMSLLGVPE
Mflv_4325|M.gilvum_PYR-GCK RALKVRVDELAKTFVDQMYDRGGE--CDFVQEVAVNFPLYVIMSLLGIPE
Mvan_2021|M.vanbaalenii_PYR-1 RALKVRVDELAKTFVDQMYERGGE--CDFVQEVAVNFPLYVIMSLLGIPE
MAB_3825|M.abscessus_ATCC_1997 RDMKLRTDELANRYVNKLLEAGGS--CDFAQDIAVHFPLYVIMSLLGIPE
MLBr_02088|M.leprae_Br4923 QALEGDIAALVDSLLDKGAAAGQF---DVIADLAFPLAVAVICRLLGVPY
:: . :. . *. ::: .: :* ::*:*
Mb2289|M.bovis_AF2122/97 ADHQRIFHWTNVILGFGDPDLAT------DFDEFMQVSADIGAYATALAE
Rv2266|M.tuberculosis_H37Rv ADHQRIFHWTNVILGFGDPDLAT------DFDEFMQVSADIGAYATALAE
MUL_3863|M.ulcerans_Agy99 ADFPRMLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTT
MMAR_3999|M.marinum_M ADFPRMLKLTQELFGSDDSEFKRG----STSEDQLPALLDMFGYFNAVTT
MAV_1609|M.avium_104 ADFPRMLKLTQELFGSDDSEFKRG----SSNEDQLPALLDMFGYFNGVTA
MSMEG_2257|M.smegmatis_MC2_155 ADFPLMLKLTQELFGNKDDEYQRS----ADEGDSMAALLEMFQYFTELTA
TH_2733|M.thermoresistible__bu ADFPLMLKLTQELFGSDDEEFKRG----ASQEDQMTALLEMFEYFTKLTA
Mflv_4325|M.gilvum_PYR-GCK SDFGRMLTYTQELFGSDDAELQRG----TTMEERGLALFDMFTYFNELTA
Mvan_2021|M.vanbaalenii_PYR-1 SDFQRMLTYTQELFGNDDAELQRG----ESMEERGLALFDMFTYFNEITA
MAB_3825|M.abscessus_ATCC_1997 SDFDRMLKLTQELFGGDDSEFQRG----TTPEEQLMALLDFFGYFSGLTA
MLBr_02088|M.leprae_Br4923 EDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVK
* : : :. * : . : * :.
Mb2289|M.bovis_AF2122/97 DRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITH
Rv2266|M.tuberculosis_H37Rv DRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITH
MUL_3863|M.ulcerans_Agy99 ARRAHPTADLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISG
MMAR_3999|M.marinum_M ARREHPTEDLASAIANARIDGEPLSDIDTVSYYLIVATAGHDTTSATISG
MAV_1609|M.avium_104 ARREHPTEDLASAIANARVDGEPLSDIDTVSYYLIVATAGHDTTSATISG
MSMEG_2257|M.smegmatis_MC2_155 SRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAAGHDTTSATISG
TH_2733|M.thermoresistible__bu SRRENPTEDLASAIANAKIDGEPLSDIDTMSYYAIVAAAGHDTTSATISG
Mflv_4325|M.gilvum_PYR-GCK SRRAQPTEDLASAIANARINGEPLSDIDTVSYYLIVATAGHDTTSATISG
Mvan_2021|M.vanbaalenii_PYR-1 ARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISG
MAB_3825|M.abscessus_ATCC_1997 SRRQHPTDDLASTIANARVDGELLSDVDTASYYTIIATAGHDTTSATIAG
MLBr_02088|M.leprae_Br4923 CRRGTPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIAN
** ** * : : .* *.. : : :: .**::** *:
Mb2289|M.bovis_AF2122/97 GVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIEL
Rv2266|M.tuberculosis_H37Rv GVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIEL
MUL_3863|M.ulcerans_Agy99 GLHALIEHPDQLARLQADPA-LMSLATEEMIRWVTPVKQFMRTASSDTVV
MMAR_3999|M.marinum_M GLHALIEHPDQLARLQADPA-LIPLATEEMIRWVTPVKQFMRTASRDTVV
MAV_1609|M.avium_104 GLQALIENPDQLQRLRDNLD-LMPLATEEMIRWVTPVKEFMRTAAKDTVV
MSMEG_2257|M.smegmatis_MC2_155 GMLALLEHPDQLERLRNDPS-LMGTATEEMIRWVTPVKAFMRTAATDTVV
TH_2733|M.thermoresistible__bu GLLALLEHPDQHERLLADPE-LMPLAVEEMIRWVTPVKAFMRTAQRDTTV
Mflv_4325|M.gilvum_PYR-GCK GLQALIENPDQLARLQQAPE-LLPLAVEEMIRWVTPVKEFMRTAQQDTEV
Mvan_2021|M.vanbaalenii_PYR-1 GLQALIENPDQLQRLQQNPG-LMPLAVEEMIRWVTPVKEFMRTAQQDAEV
MAB_3825|M.abscessus_ATCC_1997 GLEALLEHPDQLARLRENPG-LMPLAVDEMIRWVTPVKEFMRTATADTEI
MLBr_02088|M.leprae_Br4923 AVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRVAAKDMTI
.: *: . *.* ..:* :*: ..: : *. * :
Mb2289|M.bovis_AF2122/97 RGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHF
Rv2266|M.tuberculosis_H37Rv RGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHF
MUL_3863|M.ulcerans_Agy99 RGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYG-VHF
MMAR_3999|M.marinum_M RGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYG-VHF
MAV_1609|M.avium_104 RGVPIAAGESVLLSYVSANRDEDVFDEPFRFDVGRDPNKHLAFGYG-VHF
MSMEG_2257|M.smegmatis_MC2_155 RDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKHVAFGYG-VHF
TH_2733|M.thermoresistible__bu RDVPIKAGESVLLSYVSGNRDEEVFDDPFGFDVGRDPNKHISFGYG-VHF
Mflv_4325|M.gilvum_PYR-GCK RGVPIAAGESVLLSYPSGNRDEDVFTDPFRFDIGRDPNKHVAFGYG-VHF
Mvan_2021|M.vanbaalenii_PYR-1 RGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKHVAFGYG-VHF
MAB_3825|M.abscessus_ATCC_1997 RGVPITEGESVLLSYPSGNRDEDIFTDPFTFDIARDPNKHLAFGFG-VHF
MLBr_02088|M.leprae_Br4923 GQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSSRHLAFAVG-SHF
: *:.: * :.*** : * ** * .. *:.*. * **
Mb2289|M.bovis_AF2122/97 CLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS
Rv2266|M.tuberculosis_H37Rv CLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS
MUL_3863|M.ulcerans_Agy99 CMGAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYS
MMAR_3999|M.marinum_M CMGAALARMEVGSFFTELLPRLKSIELSGDPQFTATTFVGGLKHLPVSYS
MAV_1609|M.avium_104 CMGAALARMEVNSFFTELLPRLKSIELTGDPELVATTFVGGLKHLPVRYS
MSMEG_2257|M.smegmatis_MC2_155 CLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGGLKHLPVRYA
TH_2733|M.thermoresistible__bu CLGAALARMEVNSFFTELLPRLKSVEPAGPAEFVATTFVGGPKHLPIRYE
Mflv_4325|M.gilvum_PYR-GCK CLGAALARMEINSFFSELLPRLTSVELAGRPEHIATIFVGGLKHLPIRYS
Mvan_2021|M.vanbaalenii_PYR-1 CLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYS
MAB_3825|M.abscessus_ATCC_1997 CLGAALARMEVNSFFSALLPRLESIEVDGNIERTSTIFVGGIKHLPIRYT
MLBr_02088|M.leprae_Br4923 CLGAALARLEATVTLSAISARFPQVQLAGELVYKPNVAMRGMSALPVQV-
*:** *** * : : :: .: . : * . **:
Mb2289|M.bovis_AF2122/97 ---
Rv2266|M.tuberculosis_H37Rv ---
MUL_3863|M.ulcerans_Agy99 LM-
MMAR_3999|M.marinum_M LV-
MAV_1609|M.avium_104 LA-
MSMEG_2257|M.smegmatis_MC2_155 LR-
TH_2733|M.thermoresistible__bu LR-
Mflv_4325|M.gilvum_PYR-GCK LTR
Mvan_2021|M.vanbaalenii_PYR-1 LTR
MAB_3825|M.abscessus_ATCC_1997 LR-
MLBr_02088|M.leprae_Br4923 ---