For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LAYPETNTATDYPFTQPDALSAPRDLGKLRQRCPVADVRFPSGDPAVVVTRYDDAKRVLDDPRVSRNMYR ADAARLSTTQLNMLELEFVSTLVDPPNHTRIRRLFAKALRRGRIEELRPRIVTIVDELLDAMLAGPMPAD AVDALARPLPRQIIGEMFGFPPGEGDRAQYWAERLFSLSLHTAEEMAAGQQEFAAFICELAEKRRAEPTG DFFSDLVAVSDVDDGQLSHLELVYLAQALFAAGIDSTWVMISRMIGLLLHKGCYGRLVADPKLIEPTVEE VLRYLPPSNLGALRYAVEDIELDDAVIPKGTTIAVSTTAANRDPRFFDDPDEFLVDRSENRHVSFGHGRF LCPGAWLARCEMQSLLRGLVTRVPTLELAADVNDLKVRTGMMNEGMLSLPVRW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3969 | cyp269A1 | - | 100% (403) | cytochrome P450 269A1 Cyp269A1 |
| M. marinum M | MMAR_4762 | cyp105Q4 | 6e-49 | 33.41% (413) | cytochrome P450 105Q4 Cyp105Q4 |
| M. marinum M | MMAR_5268 | cyp164A3 | 1e-34 | 31.71% (369) | cytochrome P450 164A3 Cyp164A3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2291c | cyp128 | 2e-33 | 31.44% (388) | cytochrome P450 128 |
| M. gilvum PYR-GCK | Mflv_2418 | - | 2e-49 | 32.59% (405) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3121 | cyp141 | 6e-50 | 31.22% (394) | cytochrome P450 141 |
| M. leprae Br4923 | MLBr_02088 | - | 3e-32 | 28.69% (373) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3961c | - | 6e-40 | 31.49% (362) | cytochrome P450 |
| M. avium 104 | MAV_2968 | - | 5e-47 | 31.80% (412) | cytochrome P450-SU2 |
| M. smegmatis MC2 155 | MSMEG_4856 | - | 2e-50 | 33.25% (409) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_4319 | - | 9e-48 | 32.18% (404) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0333 | cyp105Q4 | 5e-48 | 33.17% (413) | cytochrome P450 105Q4 Cyp105Q4 |
| M. vanbaalenii PYR-1 | Mvan_4234 | - | 6e-47 | 31.85% (405) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3961c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2418|M.gilvum_PYR-GCK -------------------------MTETLA---QETVS-VPDYPMERSA
Mvan_4234|M.vanbaalenii_PYR-1 -------------------------MTETLA---QEAVS-VPEYPMERTA
MSMEG_4856|M.smegmatis_MC2_155 -------------------------MSETLT---QPSATDIPGYPMERAA
TH_4319|M.thermoresistible__bu -----------------------VNVSDTLTGTDADATAAIPEYPMERDG
MUL_0333|M.ulcerans_Agy99 -------------------------MSDTLASPSPETAAGIPDYPMSRSA
MAV_2968|M.avium_104 -------------------------MTQPST----DADTDIPDFPMTRAP
MMAR_3969|M.marinum_M --------------------------------MAYPETNTATDYPFTQP-
Rv3121|M.tuberculosis_H37Rv -----------------------------------MTSTSIPTFPFDRP-
MLBr_02088|M.leprae_Br4923 ----------------------MRTCVPTRTCVYAFIEYLSHNRPMGTNP
Mb2291c|M.bovis_AF2122/97 MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTRRRASSG
MAB_3961c|M.abscessus_ATCC_199 ----MP----------------AAQQRELQRAGTVHR------------V
Mflv_2418|M.gilvum_PYR-GCK GCPFAP----------------PRQMLDMNAVKPLSR------------V
Mvan_4234|M.vanbaalenii_PYR-1 GCPFAP----------------PQQMLEMNQVKPLSR------------V
MSMEG_4856|M.smegmatis_MC2_155 ACPFAP----------------PPQMLDMNKAKGLSR------------V
TH_4319|M.thermoresistible__bu RCPFAP----------------PPGVMELAAAKPLSR------------V
MUL_0333|M.ulcerans_Agy99 GCPFAP----------------PPGVMSLAAAKPLTR------------V
MAV_2968|M.avium_104 GCPFAP----------------PPKVLQLNADKQLSR------------V
MMAR_3969|M.marinum_M -DALSA----------------PRDLGKLRQRCPVAD------------V
Rv3121|M.tuberculosis_H37Rv -VPTEP----------------SPMLSELRNSCPVAP------------I
MLBr_02088|M.leprae_Br4923 PSLVEA----------------QMLLLRLIDPGTRADPFPVYRALIDYGP
Mb2291c|M.bovis_AF2122/97 GIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLT
.
MAB_3961c|M.abscessus_ATCC_199 TTAVGDPAWLITGYATVRQLFDDERVGRSHPE---------------PDT
Mflv_2418|M.gilvum_PYR-GCK RIWNGTTPWLVTGHEAARTLFADPRVSVDDRI---------------EGF
Mvan_4234|M.vanbaalenii_PYR-1 RIWNGTTPWLVTGHEVARTLFADSRVSVDDRR---------------EGF
MSMEG_4856|M.smegmatis_MC2_155 RIWDGSTPWLITGHEEARALFADSRVSVDDRR---------------PGF
TH_4319|M.thermoresistible__bu RIWDGSTPWLVTGYETARALFADSRVSVDDRR---------------PGF
MUL_0333|M.ulcerans_Agy99 RIWDGSAPWLITGYEQVRELFSGSRVSVDDRV---------------PGF
MAV_2968|M.avium_104 RIWDGSTPWLVHGYQAIRALFADARTSVDDRL---------------PGY
MMAR_3969|M.marinum_M RFPSGDPAVVVTRYDDAKRVLDDPRVSRNMYR---------------ADA
Rv3121|M.tuberculosis_H37Rv ELPSGHTAWLVTRFDDVKGVLSDKRFSCR-------------------AA
MLBr_02088|M.leprae_Br4923 MQLPGMPLTVFSSFSDCDEALRHPLSASDRLK---------------ATL
Mb2291c|M.bovis_AF2122/97 DFDPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNH
. . :
MAB_3961c|M.abscessus_ATCC_199 AAR--SGDSAFF-GGPIGSYETEREDHARGRRLMQPHFTPKQMRTLAGRV
Mflv_2418|M.gilvum_PYR-GCK PHWNEHMLATVN-KRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVI
Mvan_4234|M.vanbaalenii_PYR-1 PHWNEHMLSTVD-KRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVI
MSMEG_4856|M.smegmatis_MC2_155 PHWNEHMLATVH-KRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEGLRPAI
TH_4319|M.thermoresistible__bu PHWNEMMRSTIY-KRPRSVFTTDAEEHTKFRRMLSKPFTFKRVEGLRPAI
MUL_0333|M.ulcerans_Agy99 PHWNAGMLSTVH-KRPRSVFTADGEEHTRFRRMLSKPFTFKRVEALRPTI
MAV_2968|M.avium_104 PHWNEGMLATVH-KRPRSVFTSDAEEHTRFRRMLSKPFTFKRVEALRPAV
MMAR_3969|M.marinum_M ARLSTTQLNMLE-LEFVSTLVD-PPNHTRIRRLFAKALRRGRIEELRPRI
Rv3121|M.tuberculosis_H37Rv AHPSSPPFVPFV-QLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVV
MLBr_02088|M.leprae_Br4923 AQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDI
Mb2291c|M.bovis_AF2122/97 DTLSSARGVTFSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMV
*: *: . : : :
MAB_3961c|M.abscessus_ATCC_199 HELADELITAMIDRGSPADFYTAVAVPLPMMVLCELLGVPYADRDEFREW
Mflv_2418|M.gilvum_PYR-GCK QEVTDECIDEILAGPQPADLVAKLALPVPTRVISDMLGVPYDDHEFFQEH
Mvan_4234|M.vanbaalenii_PYR-1 QQVTDECIDEILAGPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEH
MSMEG_4856|M.smegmatis_MC2_155 QKITDECIDAILAGPQPADIVDKLALPVPTVVISEMLGVPYEDHEFFQEH
TH_4319|M.thermoresistible__bu QKITDDHIDKILAGPKPADLVTALALPVPSLVISEMLGVPYEDAEFFQEH
MUL_0333|M.ulcerans_Agy99 QQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQHH
MAV_2968|M.avium_104 QKITDDHIDALLRGPNPGDIVSTVSLPVPSLVISELLGVPYEDAEFFQTQ
MMAR_3969|M.marinum_M VTIVDELLDAMLAGPMPADAVDALARPLPRQIIGEMFGFPPGEGDRAQYW
Rv3121|M.tuberculosis_H37Rv QQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVHELAAH
MLBr_02088|M.leprae_Br4923 AALVDSLLDKGAAAG-QFDVIADLAFPLAVAVICRLLGVPYEDAPEFGRV
Mb2291c|M.bovis_AF2122/97 DQLARELVGGLLTQT-PADVVSTVAAPMPMRAITSVLGVDGPDEAAFCRL
:. . : * :: *: : ::*.
MAB_3961c|M.abscessus_ATCC_199 TVAASN------------TRDRSRSEWGMGQLFVYGMQLVGRKRQQPGDD
Mflv_2418|M.gilvum_PYR-GCK ANAGLAR-----------YAAADAMQKGAMSLHQYLINLVEEKQANPAED
Mvan_4234|M.vanbaalenii_PYR-1 ANAGLAR-----------YAAADAMQKGAMSLHQYLINLVEEKQAHPAED
MSMEG_4856|M.smegmatis_MC2_155 ANAGLAR-----------YAAADAMQKGAMSLHQYLIDLIEKKQAEPAED
TH_4319|M.thermoresistible__bu ANRGLDR-----------YAKAEDNMSKGMSLSQYLIKLVEAKMQNPAED
MUL_0333|M.ulcerans_Agy99 ANVGLAR-----------YATGADTVKGAMSLHKYLAELVEAKMANPAED
MAV_2968|M.avium_104 AQRGMGR-----------YATEEDTAQGAASLAKYLANLVRAKMQSPSED
MMAR_3969|M.marinum_M AERLFSLS----------LHTAEEMAAGQQEFAAFICELAEKRRAEPTGD
Rv3121|M.tuberculosis_H37Rv VDAAMSVC----------EIGDEEVSRRWSALCTMVIDILHRKLAEPGDD
MLBr_02088|M.leprae_Br4923 SALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTPGED
Mb2291c|M.bovis_AF2122/97 SNQAVRITDVALS-----ASGLISLVQGFAGFRRLRALFTHRRDNGLLRE
: : : :
MAB_3961c|M.abscessus_ATCC_199 VISRLCT-----IDGVADHEIASQSMALLLGGHETTVVQLGLATLLLLAN
Mflv_2418|M.gilvum_PYR-GCK AVSDLAER--VTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLEN
Mvan_4234|M.vanbaalenii_PYR-1 AVSDLAER--VTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLEN
MSMEG_4856|M.smegmatis_MC2_155 AVSDLAER--VTAGELSVKEAAQLGTGLLIAGHETTANMIGIGILALLEN
TH_4319|M.thermoresistible__bu AVSDLAER--VKAGEIDVKEAAQLGTGLLIAGHETTANMIGLGVLALLEH
MUL_0333|M.ulcerans_Agy99 AVSDLAER--VKAGELSVKEAAQLGTGLLIAGHETTANMIGLGVLALLVN
MAV_2968|M.avium_104 LVSDLAER--VNAEEISVREAAQLATGVLIAGHETTANMISLSVAALLEH
MMAR_3969|M.marinum_M FFSDLVAVSDVDDGQLSHLELVYLAQALFAAGIDSTWVMISRMIGLLLHK
Rv3121|M.tuberculosis_H37Rv LLSTIAQAN-RQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHH
MLBr_02088|M.leprae_Br4923 LISRLIELD-ESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRN
Mb2291c|M.bovis_AF2122/97 CTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMISTLFLTLADY
: : :. .* ::. : :
MAB_3961c|M.abscessus_ATCC_199 PEQWALLVS--QPDLVPNAVEETLRASRTGGGEIPRYAREDLEIDGVHIA
Mflv_2418|M.gilvum_PYR-GCK PEQAALLRDSEDPKFIANAVEELMRYLSIIQNGQRRVAIEDIEIAGETIR
Mvan_4234|M.vanbaalenii_PYR-1 PEQAALLRDSDDPKFIANAVEELMRYLSIIQNGQRRVATEDIEIGGETIR
MSMEG_4856|M.smegmatis_MC2_155 PEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQRRVAVEDIEIGGETIK
TH_4319|M.thermoresistible__bu PEQADFLRSAEDPKAIATAIEELMRYLSIIQNGQRRVAVEDIEIAGETIR
MUL_0333|M.ulcerans_Agy99 PDQAGILRDAHDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGGETIR
MAV_2968|M.avium_104 PDQRALLCDTDDPKVIATAVEELMRYLSIIQTGQRRIAIEDIEIGGETIR
MMAR_3969|M.marinum_M G---CYGRLVADPKLIEPTVEEVLRYLPPSNLGALRYAVEDIELDDAVIP
Rv3121|M.tuberculosis_H37Rv RDQYERLVE--DPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALS
MLBr_02088|M.leprae_Br4923 PSQWKALSS--NPQRAPLVVEETLRYDPAIHLIG-RVAAKDMTIGQTTLT
Mb2291c|M.bovis_AF2122/97 PDQLTLLAQ--QPDLIPSAIEEHLRFISP-IQNICRTTRVDYSVGQAVIP
:* .:** :* * . * : :
MAB_3961c|M.abscessus_ATCC_199 AGELLLLDVGAANHDPAVFGCPDQLDVARK-HLAHVIFGYGSRYCVGAPL
Mflv_2418|M.gilvum_PYR-GCK AGEGIILDLAPANWDPQAYPEPDKLDLTRD-ANQQLGFGYGRHQCVGQQL
Mvan_4234|M.vanbaalenii_PYR-1 AGEGIILDLAPANWDARAFPEPDKLDLTRD-ATQQLGFGYGRHQCVGQQL
MSMEG_4856|M.smegmatis_MC2_155 AGEGIIIDLVPANWDAKAFPEPDKLDLTRD-AGQQLGFGYGRHQCVGQQL
TH_4319|M.thermoresistible__bu AGEGIILDLAPANWDPATFPEPDRLDLQRS-DAPQLGFGYGRHQCVGMQL
MUL_0333|M.ulcerans_Agy99 AGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGRHQCVGQQL
MAV_2968|M.avium_104 AGEGIILDVAPANWDARQFPNPDRLDLRRQ-DGPHVGFGYGRHQCVGQQL
MMAR_3969|M.marinum_M KGTTIAVSTTAANRDPRFFDDPDEFLVDRS-ENRHVSFGHGRFLCPGAWL
Rv3121|M.tuberculosis_H37Rv AGSPAFTSITSANRDSDQFLDPDEFDVERN-PNEHIAFGYGPHACPASAY
MLBr_02088|M.leprae_Br4923 EGDTMVLLLAAANRDPAVYSRPDEFDPDRP-SSRHLAFAVGSHFCLGAAL
Mb2291c|M.bovis_AF2122/97 AGSLVLLAWGAANRDPRQYEDPDVFRADRN-PVGHLAFGSGIHLCPGTQL
* .** *. : ** : * :: *. * * .
MAB_3961c|M.abscessus_ATCC_199 ARMQLTEVLGQLVERLPGLHLRRDISELTMRG-DLLTGGLREVPVGW--
Mflv_2418|M.gilvum_PYR-GCK ARAELQIVFHTLLRRIPTLKLAIPIDEVPFKH-DRLAYGVYELPVTW--
Mvan_4234|M.vanbaalenii_PYR-1 ARAELQIVFHTLLRRIPTMKPAIPLEEVPFKH-DRLAYGVYELPVTW--
MSMEG_4856|M.smegmatis_MC2_155 ARAELQIVFHTLLRRIPTLRLAIPLEEVPFKH-DRLAYGVYELPVAW--
TH_4319|M.thermoresistible__bu ARAELQIVFPTLLRRIPTLKLATTIDEIPFKH-DRLAYGVYELPVTW--
MUL_0333|M.ulcerans_Agy99 ARTELQIVYRTLLQRIPTLTLATALEDVPFKD-DRLAYGVYELPVTW--
MAV_2968|M.avium_104 ARMELQIVLPTLLRRVPTLRLAAPLDELPFKH-DALAYGLYELPVTW--
MMAR_3969|M.marinum_M ARCEMQSLLRGLVTRVPTLELAADVNDLKVRT-GMMNEGMLSLPVRW--
Rv3121|M.tuberculosis_H37Rv SRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT
MLBr_02088|M.leprae_Br4923 ARLEATVTLSAISARFPQVQLAG---ELVYKP-NVAMRGMSALPVQV--
Mb2291c|M.bovis_AF2122/97 ARMEGQAILREIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP
:* : .. : :