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SQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPPG FVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARDG EASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGART NPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPAV EELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGHG VHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0682 | - | - | 100% (406) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_4234 | - | 5e-63 | 36.30% (405) | cytochrome P450 |
| M. vanbaalenii PYR-1 | Mvan_5481 | - | 2e-51 | 37.27% (373) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2289 | cyp124 | 2e-44 | 33.07% (375) | cytochrome P450 124 CYP124 |
| M. gilvum PYR-GCK | Mflv_0225 | - | 0.0 | 82.64% (409) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv3121 | cyp141 | 3e-45 | 33.08% (396) | cytochrome P450 141 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-50 | 38.64% (308) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_3961c | - | 2e-50 | 33.33% (393) | cytochrome P450 |
| M. marinum M | MMAR_4762 | cyp105Q4 | 3e-62 | 36.88% (404) | cytochrome P450 105Q4 Cyp105Q4 |
| M. avium 104 | MAV_2464 | - | 2e-71 | 40.10% (409) | cytochrome P450 family protein |
| M. smegmatis MC2 155 | MSMEG_0762 | - | 1e-179 | 77.39% (398) | cytochrome P450 FAS1 |
| M. thermoresistible (build 8) | TH_4319 | - | 2e-68 | 38.24% (408) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0333 | cyp105Q4 | 9e-62 | 36.63% (404) | cytochrome P450 105Q4 Cyp105Q4 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0682|M.vanbaalenii_PYR-1 -------------MSQAV---RPELPPVHMRRDG---FDPTPQLRE----
Mflv_0225|M.gilvum_PYR-GCK -------------MSQATGEAAPDLPPLHMRRDG---FDPTPHLRE----
MSMEG_0762|M.smegmatis_MC2_155 -------------MTQAQ-----ALPPLHIRRDA---FDPTPELGE----
MMAR_4762|M.marinum_M ---------MSDTLASPSPETASGIPDYPMSRSAGCPFAPPPGVMA----
MUL_0333|M.ulcerans_Agy99 ---------MSDTLASPSPETAAGIPDYPMSRSAGCPFAPPPGVMS----
TH_4319|M.thermoresistible__bu -------VNVSDTLTGTDADATAAIPEYPMERDGRCPFAPPPGVME----
MAV_2464|M.avium_104 ---------MSISFETSESRADAELPVLPMPRAAHCPLAPPPEFVD----
MAB_3961c|M.abscessus_ATCC_199 --------------------------------------MPAAQQRE----
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGT----
Rv3121|M.tuberculosis_H37Rv ---------------------MTSTSIPTFPFDRPVPTEPSPMLSE----
Mb2289|M.bovis_AF2122/97 ------MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFA
Mvan_0682|M.vanbaalenii_PYR-1 IRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPPGFVVPGA
Mflv_0225|M.gilvum_PYR-GCK IREREGVRSVTNAFGMQVYLFTRYDDIKTVLSDHSRFSNGRPPGFVVPGA
MSMEG_0762|M.smegmatis_MC2_155 IRAGEGVHVTVNPFGMQVYLVTRHEDVKTVLSDHERFSNSRPPGFVLPGA
MMAR_4762|M.marinum_M LAAAKPLTRVRIWDGSTPWLITGYEQVRELFSDSRVSVDDRLPGFPHWNA
MUL_0333|M.ulcerans_Agy99 LAAAKPLTRVRIWDGSAPWLITGYEQVRELFSGSRVSVDDRVPGFPHWNA
TH_4319|M.thermoresistible__bu LAAAKPLSRVRIWDGSTPWLVTGYETARALFADSRVSVDDRRPGFPHWNE
MAV_2464|M.avium_104 WRQQPGLRRA-LFQGNPVWVVSRYHDIRAALVDPRLSAKT-IP-----DS
MAB_3961c|M.abscessus_ATCC_199 LQRAGTVHRVTTAVGDPAWLITGYATVRQLFDDERVGRSHPEP-----DT
MLBr_02088|M.leprae_Br4923 RADPFPVYRALIDYG-PMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKA
Rv3121|M.tuberculosis_H37Rv LRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPFV
Mb2289|M.bovis_AF2122/97 TLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNI
: .
Mvan_0682|M.vanbaalenii_PYR-1 PPIDEDEQARSRAGNLLG-----LDPPEHQRLRRMLTPEFTLRRMRRLQP
Mflv_0225|M.gilvum_PYR-GCK PPVDEETQARARAGNLLG-----LDPPEHQRLRRMLTPEFTHRRMQRLRP
MSMEG_0762|M.smegmatis_MC2_155 PQISAEEQASNRAGNLLG-----LDPPEHQRLRRMLTPEFTIRRIKRLEP
MMAR_4762|M.marinum_M GMLS---TVHKRPRSVFT-----ADGEEHTRFRRMLSKPFTFKRVEALRP
MUL_0333|M.ulcerans_Agy99 GMLS---TVHKRPRSVFT-----ADGEEHTRFRRMLSKPFTFKRVEALRP
TH_4319|M.thermoresistible__bu MMRS---TIYKRPRSVFT-----TDAEEHTKFRRMLSKPFTFKRVEGLRP
MAV_2464|M.avium_104 IMPT---DADNKVPVMFAR----TDDPEHHRLRRMLTGNFTFRRCESMRP
MAB_3961c|M.abscessus_ATCC_199 AARSGDSAFFGGPIGSYE-----TEREDHARGRRLMQPHFTPKQMRTLAG
MLBr_02088|M.leprae_Br4923 TLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEG
Rv3121|M.tuberculosis_H37Rv PFVQLCPSLLS------------IDGPQHTAARRLLAQGLNPGFIARMRP
Mb2289|M.bovis_AF2122/97 TINDQTPELAEYFGSMIV-----LDDPRHQRLRSIVSRAFTPKVVARIEA
: * * :: : :
Mvan_0682|M.vanbaalenii_PYR-1 RIAEIVDAQLDALAAARDGEASADLVQHFALPIPSLVICELLGVPYADRD
Mflv_0225|M.gilvum_PYR-GCK RIAEIVDTQIDALAAAG---RPADLVEHFALPIPSLVICELLGVPYADRD
MSMEG_0762|M.smegmatis_MC2_155 RIVEIVDAHLDAMESAG---PPADIVADFALPIPSLVICELLGVPYEDRT
MMAR_4762|M.marinum_M TIQQITDEHIDAMLAGP---QPADLVAKLALPVPSLVISQLLGVPYEDAE
MUL_0333|M.ulcerans_Agy99 TIQQITDEHIDAMLAGP---QPADLVAKLALPVPSLVISQLLGVPYEDAE
TH_4319|M.thermoresistible__bu AIQKITDDHIDKILAGP---KPADLVTALALPVPSLVISEMLGVPYEDAE
MAV_2464|M.avium_104 QIQDTVDHYLDRMVDGG---VPADLVREFALPVPSLVIALLLGVPPEDLE
MAB_3961c|M.abscessus_ATCC_199 RVHELADELITAMIDRG---SPADFYTAVAVPLPMMVLCELLGVPYADRD
MLBr_02088|M.leprae_Br4923 DIAALVDSLLDKGAAAG----QFDVIADLAFPLAVAVICRLLGVPYEDAP
Rv3121|M.tuberculosis_H37Rv VVQQIVDNALDDLAAAEP---PVDFQEIVSVPIGEQLMAKLLGVEPKTVH
Mb2289|M.bovis_AF2122/97 AVRDRAHRLVSSMIANNP-DRQADLVSELAGPLPLQIICDMMGIPKADHQ
: .. : *. .: *: ::. ::*:
Mvan_0682|M.vanbaalenii_PYR-1 DFQRRSARQLDLSI-----------PIPERIELAREGRAYMGSLVAGART
Mflv_0225|M.gilvum_PYR-GCK DFQRRSARQLDLSI-----------PIPERLELQREGREYMAALVAGARR
MSMEG_0762|M.smegmatis_MC2_155 DFQQRSARQLDLSA-----------PMPERLELQRQGRAYMRGLVERSRT
MMAR_4762|M.marinum_M MFQHHANVGLARYA-----------TGADTVKGAMSLHKYLAELVEAKMA
MUL_0333|M.ulcerans_Agy99 MFQHHANVGLARYA-----------TGADTVKGAMSLHKYLAELVEAKMA
TH_4319|M.thermoresistible__bu FFQEHANRGLDRYA-----------KAEDNMSKGMSLSQYLIKLVEAKMQ
MAV_2464|M.avium_104 LFQFNTTKGLDQKS-----------SDEEKGKAFGAMYAYIEELVQRKAR
MAB_3961c|M.abscessus_ATCC_199 EFREWTVAASNTRD-----------RSRSEWGMG-QLFVYGMQLVGRKRQ
MLBr_02088|M.leprae_Br4923 EFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVKCRRG
Rv3121|M.tuberculosis_H37Rv ELAAHVDAAMSVCEIG----------DEEVSRRWSALCTMVIDILHRKLA
Mb2289|M.bovis_AF2122/97 RIFHWTNVILGFGDPD------LATDFDEFMQVSADIGAYATALAEDRRV
: . :
Mvan_0682|M.vanbaalenii_PYR-1 NPGDDILG--MLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLA
Mflv_0225|M.gilvum_PYR-GCK HPGDDILG--MLIREHGGELTDDELIGVASLLLLAGHETTSNMLALGVLA
MSMEG_0762|M.smegmatis_MC2_155 RPGDDILG--MLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGLGVLA
MMAR_4762|M.marinum_M NPAEDAVS-DLAERVKAGELSVKEAAQLGTGLLIAGHETTANMIGLGVLA
MUL_0333|M.ulcerans_Agy99 NPAEDAVS-DLAERVKAGELSVKEAAQLGTGLLIAGHETTANMIGLGVLA
TH_4319|M.thermoresistible__bu NPAEDAVS-DLAERVKAGEIDVKEAAQLGTGLLIAGHETTANMIGLGVLA
MAV_2464|M.avium_104 EPGDDLISRLITEYVATGQLDHATTAMNSVIMMQAGHETTANMISLGTVA
MAB_3961c|M.abscessus_ATCC_199 QPGDDVIS----RLCTIDGVADHEIASQSMALLLGGHETTVVQLGLATLL
MLBr_02088|M.leprae_Br4923 TPGEDLISRLIELDESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLA
Rv3121|M.tuberculosis_H37Rv EPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLAS
Mb2289|M.bovis_AF2122/97 NHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLA
:* . : :: .* :*. : .
Mvan_0682|M.vanbaalenii_PYR-1 LLRHPEQLAAVR--EDPDAVAPAVEELLRWLSIVHTAIPRITTTDVEIAG
Mflv_0225|M.gilvum_PYR-GCK LLRHPDQLAAIR--DDPAAVAPAVEELLRWLSIVQTSIPRITTTDVEIAG
MSMEG_0762|M.smegmatis_MC2_155 LLRHPDQLACVR--DDPDAVGPAIEELLRWLSIVSTALPRITTTDVELAG
MMAR_4762|M.marinum_M LLVNPDQAGILRDAQDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGG
MUL_0333|M.ulcerans_Agy99 LLVNPDQAGILRDAHDPKIVANAVEELLRYLSIIQNGQRRVAHEDIHIGG
TH_4319|M.thermoresistible__bu LLEHPEQADFLRSAEDPKAIATAIEELMRYLSIIQNGQRRVAVEDIEIAG
MAV_2464|M.avium_104 LLGHPEIYARLGQTDDSAVVANIVEELMRYLSIVHSQVDRVATEGLTIAG
MAB_3961c|M.abscessus_ATCC_199 LLANPEQWALLVS--QPDLVPNAVEETLRASRTGGGEIPRYAREDLEIDG
MLBr_02088|M.leprae_Br4923 MLRNPSQWKALSS--NPQRAPLVVEETLRYDPAIH-LIGRVAAKDMTIGQ
Rv3121|M.tuberculosis_H37Rv LLHHRDQYERLVE--DPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAG
Mb2289|M.bovis_AF2122/97 LSRYPEQRDRWWS-DFDGLAPTAVEEIVRWASPVV-YMRRTLTQDIELRG
: . :** :* * .: :
Mvan_0682|M.vanbaalenii_PYR-1 VSIPAGQLVFASLPSGNRDDEFIERPEVFDITR-GAMGHLAFGHG-VHHC
Mflv_0225|M.gilvum_PYR-GCK VAIPAGQLVFASLPAGNRDPEFIEHPEVLDIGR-GAPGHLAFGHG-VHHC
MSMEG_0762|M.smegmatis_MC2_155 VTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRR-GAPGHLAFGHG-VHHC
MMAR_4762|M.marinum_M ETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYG-RHQC
MUL_0333|M.ulcerans_Agy99 ETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYG-RHQC
TH_4319|M.thermoresistible__bu ETIRAGEGIILDLAPANWDPATFPEPDRLDLQRSDAP-QLGFGYG-RHQC
MAV_2464|M.avium_104 QLIRAGEFVVMNLPAGNWDTEFVDNPESFDADR-NPRGHLGFGYG-VHQC
MAB_3961c|M.abscessus_ATCC_199 VHIAAGELLLLDVGAANHDPAVFGCPDQLDVAR-KHLAHVIFGYG-SRYC
MLBr_02088|M.leprae_Br4923 TTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDR-PSSRHLAFAVG-SHFC
Rv3121|M.tuberculosis_H37Rv TALSAGSPAFTSITSANRDSDQFLDPDEFDVER-NPNEHIAFGYG-PHAC
Mb2289|M.bovis_AF2122/97 TKMAAGDKVSLWYCSANRDESKFADPWTFDLAR-NPNPHLGFGGGGAHFC
: * ..* * * : * :: *. * : *
Mvan_0682|M.vanbaalenii_PYR-1 LGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRS-FHFIYGLKSLEV
Mflv_0225|M.gilvum_PYR-GCK LGAPLARMEMAIAFPALFRRFPSLEPAEDFADVAFRS-FHFIYGLKSLEV
MSMEG_0762|M.smegmatis_MC2_155 LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRP-FHFIYGLQSLAV
MMAR_4762|M.marinum_M VGQQLARAELQIVYRTLLQRIPTLTLATALEDVPFKD-DRLAYGVYELPV
MUL_0333|M.ulcerans_Agy99 VGQQLARTELQIVYRTLLQRIPTLTLATALEDVPFKD-DRLAYGVYELPV
TH_4319|M.thermoresistible__bu VGMQLARAELQIVFPTLLRRIPTLKLATTIDEIPFKH-DRLAYGVYELPV
MAV_2464|M.avium_104 IGANLARVEMQVAFATLARRLPGLRLAVPPEQLKFK--DANIYGMKELPV
MAB_3961c|M.abscessus_ATCC_199 VGAPLARMQLTEVLGQLVERLPGLHLRRDISELTMRG-DLLTGGLREVPV
MLBr_02088|M.leprae_Br4923 LGAALARLEATVTLSAISARFPQVQLAG---ELVYKP-NVAMRGMSALPV
Rv3121|M.tuberculosis_H37Rv PASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLV
Mb2289|M.bovis_AF2122/97 LGANLARREIRVAFDELRRQMPDVVATEEPARLLSQF----IHGIKTLPV
. :* : ::* : : : *: : *
Mvan_0682|M.vanbaalenii_PYR-1 TW--
Mflv_0225|M.gilvum_PYR-GCK SW--
MSMEG_0762|M.smegmatis_MC2_155 AW--
MMAR_4762|M.marinum_M TW--
MUL_0333|M.ulcerans_Agy99 TW--
TH_4319|M.thermoresistible__bu TW--
MAV_2464|M.avium_104 SW--
MAB_3961c|M.abscessus_ATCC_199 GW--
MLBr_02088|M.leprae_Br4923 QV--
Rv3121|M.tuberculosis_H37Rv TWPT
Mb2289|M.bovis_AF2122/97 TWS-