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MNLRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPKGTRFQRVSIAGVPVQRVQPPHAATSG TLIYLHGGAYALGSARGYRGLAAQLAAAAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLLDDGLDPKTT VIAGDSAGGGLTLALAMALRDRGIQAPAALGLICPWADLAVDIEATRPALRDPLILPSMCTEWAPRYVGS SDPRLPGISPVYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVSLLPE ARDAIADLGARLRGHLHQSQGQPRGVVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3084 | lipR | - | 100% (308) | PROBABLE ACETYL-HYDROLASE/ESTERASE LIPR |
| M. tuberculosis H37Rv | Rv1076 | lipU | 2e-22 | 31.02% (274) | lipase LipU |
| M. tuberculosis H37Rv | Rv3487c | lipF | 9e-18 | 28.45% (239) | esterase/lipase LipF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3111 | lipR | 1e-177 | 100.00% (308) | acetyl-hydrolase/esterase LipR |
| M. gilvum PYR-GCK | Mflv_4606 | - | 8e-25 | 31.44% (229) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | MLBr_00314 | - | 4e-21 | 31.75% (274) | putative esterase |
| M. abscessus ATCC 19977 | MAB_0141c | - | 2e-33 | 34.93% (229) | putative esterase |
| M. marinum M | MMAR_3137 | - | 2e-28 | 28.81% (302) | esterase/lipase |
| M. avium 104 | MAV_3032 | - | 1e-25 | 31.02% (245) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 2e-32 | 31.56% (263) | acetyl-hydrolase |
| M. thermoresistible (build 8) | TH_2573 | - | 2e-21 | 35.61% (205) | PUTATIVE Alpha/beta hydrolase fold-3 domain protein |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 4e-23 | 30.67% (238) | lipase LipU_1 |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | 2e-23 | 29.73% (259) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3084|M.tuberculosis_H37Rv ------------------------------------------------MN
Mb3111|M.bovis_AF2122/97 ------------------------------------------------MN
Mflv_4606|M.gilvum_PYR-GCK ----------------------------------MS--SPARPNPSMASH
MMAR_3137|M.marinum_M ----------------------------------MTNTDAADRRPSLASH
MLBr_00314|M.leprae_Br4923 -----------------------------MAISAGAPVEIVESGPSIAAR
MUL_2832|M.ulcerans_Agy99 MSGVTTFDKLFGPPYDAIRPRRNRRVGRRAASGHGAHVEVVESGPSIAAR
MAV_3032|M.avium_104 ---------------------------------------------MTSPP
Mvan_2672|M.vanbaalenii_PYR-1 ---------------------------------------------MTVNP
TH_2573|M.thermoresistible__bu ------------------------------------------VARSSKLP
MAB_0141c|M.abscessus_ATCC_199 ----------------MTDPAHKPTFGDTVTIETVGSDSAVQRSSHAVAR
MSMEG_3010|M.smegmatis_MC2_155 ---------------------------MIQACVILRHHGNGLVTAHTLAP
Rv3084|M.tuberculosis_H37Rv LRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPKGTRFQRVS
Mb3111|M.bovis_AF2122/97 LRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPKGTRFQRVS
Mflv_4606|M.gilvum_PYR-GCK LVAATARRVLRPLTQVIPANDHGFAVMDRVLRGTLVVSRPRRAISVEKVD
MMAR_3137|M.marinum_M FVAMTSRNTLRPLSQLIPSSAHGLAVMDRVLRMALVGSRPRRSVAVRTID
MLBr_00314|M.leprae_Br4923 LASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVNL
MUL_2832|M.ulcerans_Agy99 VVSLASRLTVRPVIAVASHFPHLPWPWSLVDFALLPITWASGIIGERVSL
MAV_3032|M.avium_104 LDPDAAARIASFGETAPMRQRGLP-AVRAGLESAPRPATMPEMASVTEAL
Mvan_2672|M.vanbaalenii_PYR-1 ATLDAVLQKVLEAVPFKLTTEGGPEPARQRFKELPRNAILPEVA-AQDLS
TH_2573|M.thermoresistible__bu LDFHPDLRRLARFIPRQAVSPVTLPLMRLATRPMTRRAPR-------DIE
MAB_0141c|M.abscessus_ATCC_199 ALLRPTLELLARIAARHPTARTHGFRAANFIELAAYPLRPSRDTRRRIVM
MSMEG_3010|M.smegmatis_MC2_155 MSINQPNDPLGVIYAEWTEEFVANPDMSLRLMRWVFEDWQRVTSEPEDVT
Rv3084|M.tuberculosis_H37Rv IAG----VPVQRVQPPHAATSG-TLIYLHGGAYALGSARGYRGLAAQLAA
Mb3111|M.bovis_AF2122/97 IAG----VPVQRVQPPHAATSG-TLIYLHGGAYALGSARGYRGLAAQLAA
Mflv_4606|M.gilvum_PYR-GCK TPFAGERVRGDWVKAANVASDAPPILYIHGGAFSMCSPETHRGLISELSA
MMAR_3137|M.marinum_M TEFAGNQIRGDWITSPAVDPHAVPLLYIHGGAYSMCSPATHRGLLGELAS
MLBr_00314|M.leprae_Br4923 SNTSAQLVRAAGVRPA--DGSGRIVLYLHGGAFLGCGANSHRRLVETLSK
MUL_2832|M.ulcerans_Agy99 PNASGHLVRASGVPPP--DGSRRVVLYMHGGAFLKGGIHSHARLAGTLSK
MAV_3032|M.avium_104 VPSAAGGIPVRIYRPTTD-SGVAVLVYLHGGGLVMGSNRSFEPLARELAS
Mvan_2672|M.vanbaalenii_PYR-1 IEGPAGPVPVRIYRPPSDEAAPPTVVFIHGGGWTVGDLDSYDGTARLHAA
TH_2573|M.thermoresistible__bu VLTLSSGIGIRLFRPPGG-GTGAAMLWIHGGGYVIGCAAQDDALCRRYAR
MAB_0141c|M.abscessus_ATCC_199 FEQFRAEWLWHKDLPDPDQAAQGAILYFHGGAFILGGLHSHRRMAARLAR
MSMEG_3010|M.smegmatis_MC2_155 YASTRIGGVPGILVKPLDADPGQMLVVLHGGGFALGSSASHRKLAGHLAR
:: :***. :
Rv3084|M.tuberculosis_H37Rv AAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLLDDG----LDPKTTVIA
Mb3111|M.bovis_AF2122/97 AAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLLDDG----LDPKTTVIA
Mflv_4606|M.gilvum_PYR-GCK AARRPVFAVRYRLVPRYPFPAAADDALIAYRWLTEGSA-ITASSGTVALA
MMAR_3137|M.marinum_M ASGRPIFAVRYRLAPRYPFPAAADDALNAYRWLVTGQP-SASGERGVAVA
MLBr_00314|M.leprae_Br4923 LADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLG----YDPEQIVLA
MUL_2832|M.ulcerans_Agy99 FADSPLLVVNYRLVPKHTVGMALEDCHDAYLWLRLRG----HAPEQIVLA
MAV_3032|M.avium_104 ASAATVVAVDYRLAPESPPPAQFDDAYAATEWVSRKAGELGVDADRLAVI
Mvan_2672|M.vanbaalenii_PYR-1 GAGAVVVSVDYRLAPEHPYPAAVDDVWAATRWVAENAAELGADPDRLAVA
TH_2573|M.thermoresistible__bu ELDVTVAAVDYRLAPENPYPIPLEDCYAALLWLTRLP---TVDPQRVVIA
MAB_0141c|M.abscessus_ATCC_199 ASGIPVLVVDYRQLPLAHITDSITDAVDSYRYLLDRG----YAPGKIVFA
MSMEG_3010|M.smegmatis_MC2_155 AFGAHAFVADFRLAPEHPYPAQIDDATAVFTSLLDNG----IDASSITFV
: * : : ..
Rv3084|M.tuberculosis_H37Rv GDSAGGGLTLALAMALRDRGIQAPAALGLICPWADLAVDIEATRPALR-D
Mb3111|M.bovis_AF2122/97 GDSAGGGLTLALAMALRDRGIQAPAALGLICPWADLAVDIEATRPALR-D
Mflv_4606|M.gilvum_PYR-GCK GDSAGGQLAAATALGAREHRLPTPDAMLLMSPVLDLTCQLAMDRDLRRRD
MMAR_3137|M.marinum_M GDSAGGQLTMATALGARSDGLPLPDSMLLMSPVLDLTCELARARELRRRD
MLBr_00314|M.leprae_Br4923 GDSAGGYLALALAQRLQDVGE-EPAALVAISPLLQLAKKGKQAHPNAKTD
MUL_2832|M.ulcerans_Agy99 GDSAGGYLAFALAQRLRARGE-EPAALVAISPLLQLAMRSKKAHPNIKSD
MAV_3032|M.avium_104 GDSAGGSLAAAVALAARDRRGPPICAQVLLYPGLDRDMSVASIAAMPD-A
Mvan_2672|M.vanbaalenii_PYR-1 GDSAGGNLAAVVAQSARD-AGIPLRFQLLWYPSTTFDTSLPSFVENAQ-A
TH_2573|M.thermoresistible__bu GGSAGGGLAAALALLARDRGEVAPVAQLLVYPMLDDRTLHRTDLDHPG-L
MAB_0141c|M.abscessus_ATCC_199 GDSAGGGLAFSAALAARDEGLPVPGGIAAISPWADLDCSAKRAHPNEAHD
MSMEG_3010|M.smegmatis_MC2_155 GDSAGASIAVATTLRLLRDGAPVPGRVITISPWLDMENSGSTIESNDATD
*.***. :: : *
Rv3084|M.tuberculosis_H37Rv PLILPSMCTEWAPRYVGSSDP------RLPGISPVYGDMSGLPPIVMQTA
Mb3111|M.bovis_AF2122/97 PLILPSMCTEWAPRYVGSSDP------RLPGISPVYGDMSGLPPIVMQTA
Mflv_4606|M.gilvum_PYR-GCK PFASAISASRTIGLYVAGADP------ADPRISVLDADLTDMPPTLIQVG
MMAR_3137|M.marinum_M PFASARSAARALDLYVAGADH------RNERISVLDADLRSMPPILIQVG
MLBr_00314|M.leprae_Br4923 AMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHVS
MUL_2832|M.ulcerans_Agy99 AMFPARAFDALVAIVAGAAARNETAGRREEIYEPLEHIAPGLPPTLIHVS
MAV_3032|M.avium_104 PLLIRDDIDYMHALVDGDAGPPT----DPYLVPAYAADLSGLPPAIVVTA
Mvan_2672|M.vanbaalenii_PYR-1 PILDLAACKGFTRWYIGDTDLSE----PPVTLVPARGNLAGLPPAYIAVA
TH_2573|M.thermoresistible__bu RLWNQSSNRFGWSAYLGDADP-------EVAVPARQTDLAGLPPAWIGVG
MAB_0141c|M.abscessus_ATCC_199 AMLSGFILSVPGELGMARGNG------LDPAWSAVNHDFHGMPAIFIQVG
MSMEG_3010|M.smegmatis_MC2_155 FLITREGLQGNIDRYLSGGASP-----TDPLVNPLYADFTGFPRLYITVS
: . .:* : ..
Rv3084|M.tuberculosis_H37Rv GDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVSLLPEARDAIA
Mb3111|M.bovis_AF2122/97 GDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVSLLPEARDAIA
Mflv_4606|M.gilvum_PYR-GCK GREMLLDDSRVFAKRLQTAGVSSQLQVFRGQIHVFQAMFRLLPEAREALR
MMAR_3137|M.marinum_M GREMLIDDSRHLADRLRSAGSSVEIQVYRGQIHVFQAMFRILPEAREAIH
MLBr_00314|M.leprae_Br4923 GSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATLSLR
MUL_2832|M.ulcerans_Agy99 GAEALLHDARLAAGKLAAAGVRAEVRVWPGQLHDFQVAAPMLPEATYSLR
MAV_3032|M.avium_104 GCDPIRDWGERYADRLRDAGVQTTVTRYPGMYHGFLMRSDATARGRLAIA
Mvan_2672|M.vanbaalenii_PYR-1 GHDPLRDDGLRYGELLTAAGVPVELHHAESLVHGYLGYAGIVPAATEATE
TH_2573|M.thermoresistible__bu TYDLFHDEDLAYAERLRAAGVPCEVEVVPGAFHGFDAIAPRAGVSRQFFD
MAB_0141c|M.abscessus_ATCC_199 SLEVLRVDVDLLARRCAEAHVPCTVQVWKHAIHDFQLGADLLPDARAAVG
MSMEG_3010|M.smegmatis_MC2_155 DTESLYADATRLAEKARAAGVDVTFEVASGQQHVFPLQAGVLPEADAAIE
: : * : .
Rv3084|M.tuberculosis_H37Rv DLGARLRGHLHQSQGQPRGVVK-------
Mb3111|M.bovis_AF2122/97 DLGARLRGHLHQSQGQPRGVVK-------
Mflv_4606|M.gilvum_PYR-GCK LGGEFLATSATVR----------------
MMAR_3137|M.marinum_M RAGNFLKASAHR-----------------
MLBr_00314|M.leprae_Br4923 QISQYIREATASKASRDRQSL--------
MUL_2832|M.ulcerans_Agy99 QIGEYIRQATG------------------
MAV_3032|M.avium_104 EIGGLLRAKFTHPLRFDVPITGRHSTPTR
Mvan_2672|M.vanbaalenii_PYR-1 RGLAALRAALA------------------
TH_2573|M.thermoresistible__bu SQCAMLRGLLRPEAA--------------
MAB_0141c|M.abscessus_ATCC_199 DMAHFIYRITDPDNLKAGTP---------
MSMEG_3010|M.smegmatis_MC2_155 SMAAWYRSAKPLAV---------------