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SSPARPNPSMASHLVAATARRVLRPLTQVIPANDHGFAVMDRVLRGTLVVSRPRRAISVEKVDTPFAGER VRGDWVKAANVASDAPPILYIHGGAFSMCSPETHRGLISELSAAARRPVFAVRYRLVPRYPFPAAADDAL IAYRWLTEGSAITASSGTVALAGDSAGGQLAAATALGAREHRLPTPDAMLLMSPVLDLTCQLAMDRDLRR RDPFASAISASRTIGLYVAGADPADPRISVLDADLTDMPPTLIQVGGREMLLDDSRVFAKRLQTAGVSSQ LQVFRGQIHVFQAMFRLLPEAREALRLGGEFLATSATVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4606 | - | - | 100% (320) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2042 | - | 4e-29 | 29.81% (322) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3735 | - | 5e-25 | 33.48% (233) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2406 | mbtJ | 8e-51 | 40.07% (302) | putative acetyl hydrolase MBTJ |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | 9e-51 | 40.07% (302) | putative acetyl hydrolase MBTJ |
| M. leprae Br4923 | MLBr_00314 | - | 7e-34 | 32.38% (315) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2076 | - | 1e-118 | 67.86% (308) | putative esterase/acetyl hydrolase |
| M. marinum M | MMAR_3137 | - | 1e-117 | 67.64% (309) | esterase/lipase |
| M. avium 104 | MAV_1798 | - | 3e-46 | 41.06% (263) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0267 | - | 3e-33 | 36.44% (247) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 6e-30 | 31.43% (315) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_3642 | mbtJ | 1e-45 | 37.03% (316) | acetyl hydrolase MbtJ |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 2e-29 | 30.12% (322) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2076|M.abscessus_ATCC_1997 -----------------MTRMDAPDWQPSLASHLVAMSSRTTLRPLAQLM
MMAR_3137|M.marinum_M -----------------MTNTDAADRRPSLASHFVAMTSRNTLRPLSQLI
Mflv_4606|M.gilvum_PYR-GCK -----------------MSSPARPN--PSMASHLVAATARRVLRPLTQVI
Mb2406|M.bovis_AF2122/97 ----------------------------------------MVLRPITGAI
Rv2385|M.tuberculosis_H37Rv ----------------------------------------MVLRPITGAI
MUL_3642|M.ulcerans_Agy99 -------------------MTDVVPVRGSLRSRTAVAVSSIMMPPIIAAI
MAV_1798|M.avium_104 ------------------------------------------------MI
TH_1370|M.thermoresistible__bu MTAPSKVPRTSPLATRAARGHYSRTFPVSDGTPSEYVEDGPSLAGRLTAL
Mvan_4675|M.vanbaalenii_PYR-1 MTAPSKVPATPHAAIAAARAGKIRRFPVSDGAPVEVVEDGPSIAGRLMGL
MLBr_00314|M.leprae_Br4923 -------------------------MAISAGAPVEIVESGPSIAARLASL
MSMEG_0267|M.smegmatis_MC2_155 --------MTSSVSTIDARP------DLSVGK--QIMHRRRSAESFALAA
MAB_2076|M.abscessus_ATCC_1997 PSN-AYGLAVMDRVLRTALVASRPRRG-VTVRKVDTVFA-GGPVRGDWIT
MMAR_3137|M.marinum_M PSS-AHGLAVMDRVLRMALVGSRPRRS-VAVRTIDTEFA-GNQIRGDWIT
Mflv_4606|M.gilvum_PYR-GCK PAN-DHGFAVMDRVLRGTLVVSRPRRA-ISVEKVDTPFA-GERVRGDWVK
Mb2406|M.bovis_AF2122/97 PPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDGRRVVGEWVY
Rv2385|M.tuberculosis_H37Rv PPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDGRRVVGEWVY
MUL_3642|M.ulcerans_Agy99 PPERAWGIWMTRQVIARLMGTLGPSLSGTHVKPVNSVLPDGRRVVGEWVH
MAV_1798|M.avium_104 PPERAWGLWLSRQIVARIMGTFGPSLSGTRVQSVDTRLPDGRRVKGEWVF
TH_1370|M.thermoresistible__bu AAYLTVRPTLAIGSFAPRLPWPWGLLDFAARAVRPVPGTVRATIRLPHCT
Mvan_4675|M.vanbaalenii_PYR-1 AAVATVKPFLTVGSYAPKLPWPWGLLDFAARVLKPAPGTVRATIGLPHCN
MLBr_00314|M.leprae_Br4923 TSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVNLSNTS
MSMEG_0267|M.smegmatis_MC2_155 GCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHRVDAKIRSVQLPDCA
: . :
MAB_2076|M.abscessus_ATCC_1997 TPAINPHAN--------PLLYIHGGAYSMCSPETHRGLLGELASASGRPI
MMAR_3137|M.marinum_M SPAVDPHAV--------PLLYIHGGAYSMCSPATHRGLLGELASASGRPI
Mflv_4606|M.gilvum_PYR-GCK AANVASDAP--------PILYIHGGAFSMCSPETHRGLISELSAAARRPV
Mb2406|M.bovis_AF2122/97 GPHNNAINAGPGG---GAIYYVHGSGYTMCSPRTHRRLTSWLSSLTGLPV
Rv2385|M.tuberculosis_H37Rv GPHNNAINAGPGG---GAIYYVHGSGYTMCSPRTHRRLTSWLSSLTGLPV
MUL_3642|M.ulcerans_Agy99 GPHLPTGPAPNRS---GAIYFVHGSGYTMCSPRTHRRLTAWLSSLTGLPV
MAV_1798|M.avium_104 GPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLTSWLSSLTGLPV
TH_1370|M.thermoresistible__bu AQLVRAPGVLPADGRRSVVLYLHGGAFLTCGAHTHGRLVTALSEFADSPV
Mvan_4675|M.vanbaalenii_PYR-1 AQLVRAAGVLPADGHRSVILYLHGGAFLTCGVNTHGRLVTALSKCADAPV
MLBr_00314|M.leprae_Br4923 AQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVETLSKLADSPI
MSMEG_0267|M.smegmatis_MC2_155 AELVCANGVS-AD---RAILYLHGGAFMTCGINTHRSLVARLSREADAAV
. : ::**..: *. :* * *: : .:
MAB_2076|M.abscessus_ATCC_1997 FAVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVAVAGDSAGGQ
MMAR_3137|M.marinum_M FAVRYRLAPRYPFPAAADDALNAYRWLVTGQPSASGERGVAVAGDSAGGQ
Mflv_4606|M.gilvum_PYR-GCK FAVRYRLVPRYPFPAAADDALIAYRWLTEGSAITASSGTVALAGDSAGGQ
Mb2406|M.bovis_AF2122/97 FSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAAEH--MVIAADSAGGH
Rv2385|M.tuberculosis_H37Rv FSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAAEH--MVIAADSAGGH
MUL_3642|M.ulcerans_Agy99 FSVDYRLAPRHRFPTAADDVRAGWDWLPGACGLSPER--MVVVADSAGGH
MAV_1798|M.avium_104 FCVDYRLAPRHRFPTAADDVRAGWDWLINTCGVPPEQ--MVIAGDSAGGH
TH_1370|M.thermoresistible__bu LVVNYRMIPKHSVGTAIDDCYDGYQWLRAK-GYEPDQ--IVLAGDSAGGY
Mvan_4675|M.vanbaalenii_PYR-1 LVVNYRMIPKHSVGTALDDCFDGYKWLREL-GYEPDQ--IVLAGDSAGGY
MLBr_00314|M.leprae_Br4923 LVVNYRLLPKHSIGMALDDCHDGYQWLRRL-GYDPEQ--IVLAGDSAGGY
MSMEG_0267|M.smegmatis_MC2_155 LNVGYRMLPKYGLAEAIDDAVAGLRWLQEQ-GYTSDQ--IVIAGDSAGGY
: * **: *:: * * . ** . :.:..*****
MAB_2076|M.abscessus_ATCC_1997 LTMATALGARAV------GLPLPDAMLLMSPVLDLRCELARAREIRRRDP
MMAR_3137|M.marinum_M LTMATALGARSD------GLPLPDSMLLMSPVLDLTCELARARELRRRDP
Mflv_4606|M.gilvum_PYR-GCK LAAATALGAREH------RLPTPDAMLLMSPVLDLTCQLAMDRDLRRRDP
Mb2406|M.bovis_AF2122/97 LTVDMLLQP-EV------AARPPAAVVLFSPLIDLTFRLGASRELQRPDP
Rv2385|M.tuberculosis_H37Rv LTVDMLLQP-EV------AARPPAAVVLFSPLIDLTFRLGASRELQRPDP
MUL_3642|M.ulcerans_Agy99 LSVDLLLQP-DV------AARPPASLVLFSPLIDLTFGLSAARERTKPDP
MAV_1798|M.avium_104 LSVDLLLQP-GV------EH--PAAMVLFSPLYDLTFELAKARERIRPDP
TH_1370|M.thermoresistible__bu LALSLAQRLLDE------GEEPAA-LVALSPLFEIDNESRAQHPNIRTDA
Mvan_4675|M.vanbaalenii_PYR-1 LALSLAERLQAEGINGFVGETPAA-IVTMSPLFEIDNEARADHPNVRTDA
MLBr_00314|M.leprae_Br4923 LALALAQRLQDV------GEEPAA-LVAISPLLQLAKKGKQAHPNAKTDA
MSMEG_0267|M.smegmatis_MC2_155 LALATALQLSSR------GEVPAAGIAAISPLTDLDPASKLEHPNARKCA
*: . : :**: :: : : .
MAB_2076|M.abscessus_ATCC_1997 FASAQSAARALDLYVGGADRGDPR------LSVLDADLTSMPPILIQVGG
MMAR_3137|M.marinum_M FASARSAARALDLYVAGADHRNER------ISVLDADLRSMPPILIQVGG
Mflv_4606|M.gilvum_PYR-GCK FASAISASRTIGLYVAGADPADPR------ISVLDADLTDMPPTLIQVGG
Mb2406|M.bovis_AF2122/97 VVRADRAARSVALYYTGVDPAHHR------LALDVAGGPPLPPTLIQVGG
Rv2385|M.tuberculosis_H37Rv VVRADRAARSVALYYTGVDPAHHR------LALDVAGGPPLPPTLIQVGG
MUL_3642|M.ulcerans_Agy99 AVRAATAARVVGLYHAGIDPTHHR------LSLDVAGGSPLPSTLIQAGA
MAV_1798|M.avium_104 ATRAANAIRLVGLYHSGVDLTHER------LTLDVARGPVLPPTLIQAGG
TH_1370|M.thermoresistible__bu MFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTLIHVSG
Mvan_4675|M.vanbaalenii_PYR-1 MFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRTLIHVSG
MLBr_00314|M.leprae_Br4923 MFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHVSG
MSMEG_0267|M.smegmatis_MC2_155 MFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKLPPVTVHVSA
:* ::...
MAB_2076|M.abscessus_ATCC_1997 REMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILPEARDAIHR
MMAR_3137|M.marinum_M REMLIDDSRHLADRLRSAGSSVEIQVYRGQIHVFQAMFRILPEAREAIHR
Mflv_4606|M.gilvum_PYR-GCK REMLLDDSRVFAKRLQTAGVSSQLQVFRGQIHVFQAMFRLLPEAREALRL
Mb2406|M.bovis_AF2122/97 AEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPRMTPEAAKAMTY
Rv2385|M.tuberculosis_H37Rv AEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPRMTPEAAKAMTY
MUL_3642|M.ulcerans_Agy99 AEMLEADARQLAADIRTAGGRCELQVWPDQMHVFQALPRMTPEAAKAMAY
MAV_1798|M.avium_104 AEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQALPRMTPEAAKAMAY
TH_1370|M.thermoresistible__bu SEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEAKRSLRQ
Mvan_4675|M.vanbaalenii_PYR-1 SEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEANRSIKQ
MLBr_00314|M.leprae_Br4923 SEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATLSLRQ
MSMEG_0267|M.smegmatis_MC2_155 DESLYSDSELLAGRLAEAQVPCELHVWHGQVHDFPLAADILPEGRRALRY
* * *:. : . ::::: *:* * .*. ::
MAB_2076|M.abscessus_ATCC_1997 AGRFLE---ASEVR------
MMAR_3137|M.marinum_M AGNFLK---ASAHR------
Mflv_4606|M.gilvum_PYR-GCK GGEFLA---TSATVR-----
Mb2406|M.bovis_AF2122/97 VAQFIR---STTARGDL---
Rv2385|M.tuberculosis_H37Rv VAQFIR---STTARGDL---
MUL_3642|M.ulcerans_Agy99 ASAFIAGSLQDNATAEAV--
MAV_1798|M.avium_104 VARFITHALQDARALTQEVH
TH_1370|M.thermoresistible__bu IGEYIREATW----------
Mvan_4675|M.vanbaalenii_PYR-1 IGEYIREATW----------
MLBr_00314|M.leprae_Br4923 ISQYIREATASKASRDRQSL
MSMEG_0267|M.smegmatis_MC2_155 VGDFVKQTTGTRLANVS---
. ::