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TNTDAADRRPSLASHFVAMTSRNTLRPLSQLIPSSAHGLAVMDRVLRMALVGSRPRRSVAVRTIDTEFAG NQIRGDWITSPAVDPHAVPLLYIHGGAYSMCSPATHRGLLGELASASGRPIFAVRYRLAPRYPFPAAADD ALNAYRWLVTGQPSASGERGVAVAGDSAGGQLTMATALGARSDGLPLPDSMLLMSPVLDLTCELARAREL RRRDPFASARSAARALDLYVAGADHRNERISVLDADLRSMPPILIQVGGREMLIDDSRHLADRLRSAGSS VEIQVYRGQIHVFQAMFRILPEAREAIHRAGNFLKASAHR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3137 | - | - | 100% (321) | esterase/lipase |
| M. marinum M | MMAR_3699 | mbtJ | 7e-49 | 39.32% (323) | acetyl hydrolase MbtJ |
| M. marinum M | MMAR_4391 | lipU | 2e-28 | 29.19% (322) | lipase LipU |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2406 | mbtJ | 4e-48 | 37.17% (304) | putative acetyl hydrolase MBTJ |
| M. gilvum PYR-GCK | Mflv_4606 | - | 1e-117 | 67.64% (309) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | 4e-48 | 37.17% (304) | putative acetyl hydrolase MBTJ |
| M. leprae Br4923 | MLBr_00314 | - | 2e-30 | 29.75% (316) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2076 | - | 1e-146 | 81.00% (321) | putative esterase/acetyl hydrolase |
| M. avium 104 | MAV_1798 | - | 1e-49 | 39.46% (294) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5271 | - | 8e-32 | 30.32% (310) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 3e-31 | 29.94% (324) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_3642 | mbtJ | 1e-48 | 38.70% (323) | acetyl hydrolase MbtJ |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 2e-28 | 28.39% (317) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1370|M.thermoresistible__bu ---MTAPSKVPRTSPLATRAARGHYSRTFPVSDGTPSEYVEDGPSLAGRL
Mvan_4675|M.vanbaalenii_PYR-1 ---MTAPSKVPATPHAAIAAARAGKIRRFPVSDGAPVEVVEDGPSIAGRL
MSMEG_5271|M.smegmatis_MC2_155 MVAMTAPSKVTRSPRAGIGPGGAYRTRKFPVSDSAPVEIVEDGTSVAGRL
MLBr_00314|M.leprae_Br4923 ----------------------------MAISAGAPVEIVESGPSIAARL
MMAR_3137|M.marinum_M --------------------------MTNTDAADRRPSLASHFVAMTSRN
MAB_2076|M.abscessus_ATCC_1997 --------------------------MTRMDAPDWQPSLASHLVAMSSRT
Mflv_4606|M.gilvum_PYR-GCK --------------------------MSSPARPN--PSMASHLVAATARR
Mb2406|M.bovis_AF2122/97 -------------------------------------------------M
Rv2385|M.tuberculosis_H37Rv -------------------------------------------------M
MUL_3642|M.ulcerans_Agy99 ----------------------------MTDVVPVRGSLRSRTAVAVSSI
MAV_1798|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu TALAAYLTVRPTLAIGSFAPRLPWPWGLLDFAARAVRPVPGTVRATIR-L
Mvan_4675|M.vanbaalenii_PYR-1 MGLAAVATVKPFLTVGSYAPKLPWPWGLLDFAARVLKPAPGTVRATIG-L
MSMEG_5271|M.smegmatis_MC2_155 ASLAAMLTIRPTLAIGSRVPHLPWPFGALNFAARMLRPSPGTIKATIA-L
MLBr_00314|M.leprae_Br4923 ASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAARAEVN-L
MMAR_3137|M.marinum_M TLRPLSQLIPSS-AHGLAVMDRVLRMALVGSRPRRS-VAVRTIDTEFA-G
MAB_2076|M.abscessus_ATCC_1997 TLRPLAQLMPSN-AYGLAVMDRVLRTALVASRPRRG-VTVRKVDTVFA-G
Mflv_4606|M.gilvum_PYR-GCK VLRPLTQVIPAN-DHGFAVMDRVLRGTLVVSRPRRA-ISVEKVDTPFA-G
Mb2406|M.bovis_AF2122/97 VLRPITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDG
Rv2385|M.tuberculosis_H37Rv VLRPITGAIPPDGPWGIWASRRIIAGLMGTFGPSLAGTRVEQVNSVLPDG
MUL_3642|M.ulcerans_Agy99 MMPPIIAAIPPERAWGIWMTRQVIARLMGTLGPSLSGTHVKPVNSVLPDG
MAV_1798|M.avium_104 -------MIPPERAWGLWLSRQIVARIMGTFGPSLSGTRVQSVDTRLPDG
: . * . : .
TH_1370|M.thermoresistible__bu PHCTAQLVRAPGVLPADGRRS-----VVLYLHGGAFLTCGAHTHGRLVTA
Mvan_4675|M.vanbaalenii_PYR-1 PHCNAQLVRAAGVLPADGHRS-----VILYLHGGAFLTCGVNTHGRLVTA
MSMEG_5271|M.smegmatis_MC2_155 PNCTAQLIRADGVLPADGTRS-----VILYLHGGAFLACGSNTHGGMATS
MLBr_00314|M.leprae_Br4923 SNTSAQLVRAAGVRPADGSGR-----IVLYLHGGAFLGCGANSHRRLVET
MMAR_3137|M.marinum_M NQIRGDWITSPAVDPHAV--------PLLYIHGGAYSMCSPATHRGLLGE
MAB_2076|M.abscessus_ATCC_1997 GPVRGDWITTPAINPHAN--------PLLYIHGGAYSMCSPETHRGLLGE
Mflv_4606|M.gilvum_PYR-GCK ERVRGDWVKAANVASDAP--------PILYIHGGAFSMCSPETHRGLISE
Mb2406|M.bovis_AF2122/97 RRVVGEWVYGPHNNAINAGPGG---GAIYYVHGSGYTMCSPRTHRRLTSW
Rv2385|M.tuberculosis_H37Rv RRVVGEWVYGPHNNAINAGPGG---GAIYYVHGSGYTMCSPRTHRRLTSW
MUL_3642|M.ulcerans_Agy99 RRVVGEWVHGPHLPTGPAPNRS---GAIYFVHGSGYTMCSPRTHRRLTAW
MAV_1798|M.avium_104 RRVKGEWVFGPRTPTSEHSRPSSIAEAIYYIHGSGYAVCSPKTHRRLTSW
.: : . : ::**..: *. :* :
TH_1370|M.thermoresistible__bu LSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPD---QIV
Mvan_4675|M.vanbaalenii_PYR-1 LSKCADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPD---QIV
MSMEG_5271|M.smegmatis_MC2_155 LSEYADSPVLVVDYRMVPKHSVGTAVDDCYDAYVWLRRAGYEPE---QIV
MLBr_00314|M.leprae_Br4923 LSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPE---QIV
MMAR_3137|M.marinum_M LASASGRPIFAVRYRLAPRYPFPAAADDALNAYRWLVTGQPSASGERGVA
MAB_2076|M.abscessus_ATCC_1997 LASASGRPIFAVKYRLAPRYPYPAAADDALNAYRWLTSGGSPGSCQRTVA
Mflv_4606|M.gilvum_PYR-GCK LSAAARRPVFAVRYRLVPRYPFPAAADDALIAYRWLTEGSAITASSGTVA
Mb2406|M.bovis_AF2122/97 LSSLTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAA--EHMV
Rv2385|M.tuberculosis_H37Rv LSSLTGLPVFSVDYRLAPRYRFPTAATDVRAAWDWLAHVCGLAA--EHMV
MUL_3642|M.ulcerans_Agy99 LSSLTGLPVFSVDYRLAPRHRFPTAADDVRAGWDWLPGACGLSP--ERMV
MAV_1798|M.avium_104 LSSLTGLPVFCVDYRLAPRHRFPTAADDVRAGWDWLINTCGVPP--EQMV
*: : *:: * **: *:: * * .: ** :.
TH_1370|M.thermoresistible__bu LAGDSAGGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRAQ
Mvan_4675|M.vanbaalenii_PYR-1 LAGDSAGGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARAD
MSMEG_5271|M.smegmatis_MC2_155 VAGDSAGGYLGLALAERLLDD------GEVPAALVAMSPLYEIDNRARAE
MLBr_00314|M.leprae_Br4923 LAGDSAGGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQA
MMAR_3137|M.marinum_M VAGDSAGGQLTMATALGARSDGLP-----LPDSMLLMSPVLDLTCELARA
MAB_2076|M.abscessus_ATCC_1997 VAGDSAGGQLTMATALGARAVGLP-----LPDAMLLMSPVLDLRCELARA
Mflv_4606|M.gilvum_PYR-GCK LAGDSAGGQLAAATALGAREHRLP-----TPDAMLLMSPVLDLTCQLAMD
Mb2406|M.bovis_AF2122/97 IAADSAGGHLTVDMLLQP-EVAAR-----PPAAVVLFSPLIDLTFRLGAS
Rv2385|M.tuberculosis_H37Rv IAADSAGGHLTVDMLLQP-EVAAR-----PPAAVVLFSPLIDLTFRLGAS
MUL_3642|M.ulcerans_Agy99 VVADSAGGHLSVDLLLQP-DVAAR-----PPASLVLFSPLIDLTFGLSAA
MAV_1798|M.avium_104 IAGDSAGGHLSVDLLLQP-GVEH-------PAAMVLFSPLYDLTFELAKA
:..***** * * ::: :**: ::
TH_1370|M.thermoresistible__bu HPNIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLP
Mvan_4675|M.vanbaalenii_PYR-1 HPNVRTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLP
MSMEG_5271|M.smegmatis_MC2_155 HPNARRDAMFPPKAFDALVEIVEAAAAR---NG--EQVYEPLDHIEPGLP
MLBr_00314|M.leprae_Br4923 HPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLP
MMAR_3137|M.marinum_M RELRRRDPFASARSAARALDLYVAGADH------RNERISVLDADLRSMP
MAB_2076|M.abscessus_ATCC_1997 REIRRRDPFASAQSAARALDLYVGGADR------GDPRLSVLDADLTSMP
Mflv_4606|M.gilvum_PYR-GCK RDLRRRDPFASAISASRTIGLYVAGADP------ADPRISVLDADLTDMP
Mb2406|M.bovis_AF2122/97 RELQRPDPVVRADRAARSVALYYTGVDP------AHHRLALDVAGGPPLP
Rv2385|M.tuberculosis_H37Rv RELQRPDPVVRADRAARSVALYYTGVDP------AHHRLALDVAGGPPLP
MUL_3642|M.ulcerans_Agy99 RERTKPDPAVRAATAARVVGLYHAGIDP------THHRLSLDVAGGSPLP
MAV_1798|M.avium_104 RERIRPDPATRAANAIRLVGLYHSGVDL------THERLTLDVARGPVLP
: : *. . : . . :*
TH_1370|M.thermoresistible__bu RTLIHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVP
Mvan_4675|M.vanbaalenii_PYR-1 RTLIHVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVS
MSMEG_5271|M.smegmatis_MC2_155 RTLIHVSGSEVLISDARKAARMLCAAGVPVEVHVWPGQMHVFQIAGNLVP
MLBr_00314|M.leprae_Br4923 RTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVP
MMAR_3137|M.marinum_M PILIQVGGREMLIDDSRHLADRLRSAGSSVEIQVYRGQIHVFQAMFRILP
MAB_2076|M.abscessus_ATCC_1997 PILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHVFQAMFRILP
Mflv_4606|M.gilvum_PYR-GCK PTLIQVGGREMLLDDSRVFAKRLQTAGVSSQLQVFRGQIHVFQAMFRLLP
Mb2406|M.bovis_AF2122/97 PTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPRMTP
Rv2385|M.tuberculosis_H37Rv PTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMHVFQALPRMTP
MUL_3642|M.ulcerans_Agy99 STLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPDQMHVFQALPRMTP
MAV_1798|M.avium_104 PTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVHVFQALPRMTP
**:... * * *:: : :.* ::::: *:**** .
TH_1370|M.thermoresistible__bu EAKRSLRQIGEYIR-----EATW----------
Mvan_4675|M.vanbaalenii_PYR-1 EANRSIKQIGEYIR-----EATW----------
MSMEG_5271|M.smegmatis_MC2_155 EAKRSLRQIGAYIR-----EATW----------
MLBr_00314|M.leprae_Br4923 EATLSLRQISQYIR-----EATASKASRDRQSL
MMAR_3137|M.marinum_M EAREAIHRAGNFLK----ASAHR----------
MAB_2076|M.abscessus_ATCC_1997 EARDAIHRAGRFLE----ASEVR----------
Mflv_4606|M.gilvum_PYR-GCK EAREALRLGGEFLA----TSATVR---------
Mb2406|M.bovis_AF2122/97 EAAKAMTYVAQFIR---STTARGDL--------
Rv2385|M.tuberculosis_H37Rv EAAKAMTYVAQFIR---STTARGDL--------
MUL_3642|M.ulcerans_Agy99 EAAKAMAYASAFIAGSLQDNATAEAV-------
MAV_1798|M.avium_104 EAAKAMAYVARFITHALQDARALTQEVH-----
** :: . ::