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VIQACVILRHHGNGLVTAHTLAPMSINQPNDPLGVIYAEWTEEFVANPDMSLRLMRWVFEDWQRVTSEPE DVTYASTRIGGVPGILVKPLDADPGQMLVVLHGGGFALGSSASHRKLAGHLARAFGAHAFVADFRLAPEH PYPAQIDDATAVFTSLLDNGIDASSITFVGDSAGASIAVATTLRLLRDGAPVPGRVITISPWLDMENSGS TIESNDATDFLITREGLQGNIDRYLSGGASPTDPLVNPLYADFTGFPRLYITVSDTESLYADATRLAEKA RAAGVDVTFEVASGQQHVFPLQAGVLPEADAAIESMAAWYRSAKPLAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3010 | - | - | 100% (328) | acetyl-hydrolase |
| M. smegmatis MC2 155 | MSMEG_5271 | - | 2e-25 | 29.96% (227) | esterase |
| M. smegmatis MC2 155 | MSMEG_3829 | - | 1e-24 | 32.05% (259) | esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3111 | lipR | 1e-32 | 31.56% (263) | acetyl-hydrolase/esterase LipR |
| M. gilvum PYR-GCK | Mflv_4606 | - | 3e-26 | 32.68% (254) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv3084 | lipR | 1e-32 | 31.56% (263) | acetyl-hydrolase/esterase LipR |
| M. leprae Br4923 | MLBr_00314 | - | 3e-25 | 30.50% (259) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2076 | - | 6e-32 | 31.39% (309) | putative esterase/acetyl hydrolase |
| M. marinum M | MMAR_3137 | - | 1e-29 | 30.42% (309) | esterase/lipase |
| M. avium 104 | MAV_3032 | - | 2e-26 | 33.60% (250) | alpha/beta hydrolase domain-containing protein |
| M. thermoresistible (build 8) | TH_1370 | lipF | 4e-24 | 28.63% (255) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_1989 | lipN | 3e-21 | 33.76% (234) | lipase/esterase LipN |
| M. vanbaalenii PYR-1 | Mvan_2162 | - | 5e-23 | 31.38% (239) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1989|M.ulcerans_Agy99 MTNSLPGETDLHPETVHATMSWLSRVQNTVTVVGAKVIPWVPDVAKRLIT
Mvan_2162|M.vanbaalenii_PYR-1 MTETVAAGESVQPP-VRRKVGVSDVVANKVAGVTLRGMPRIPHPVKRVLL
MAV_3032|M.avium_104 ----------------------------------MTSPPLDPDAAARIAS
Mb3111|M.bovis_AF2122/97 ---------------------------------------------MNLRK
Rv3084|M.tuberculosis_H37Rv ---------------------------------------------MNLRK
MAB_2076|M.abscessus_ATCC_1997 -------------------------------MTRMDAPDWQPSLASHLVA
MMAR_3137|M.marinum_M -------------------------------MTNTDAADRRPSLASHFVA
Mflv_4606|M.gilvum_PYR-GCK -------------------------------MSSPARPN--PSMASHLVA
MLBr_00314|M.leprae_Br4923 --------------------------MAISAGAPVEIVESGPSIAARLAS
TH_1370|M.thermoresistible__bu -MTAPSKVPRTSPLATRAARGHYSRTFPVSDGTPSEYVEDGPSLAGRLTA
MSMEG_3010|M.smegmatis_MC2_155 ---------------------------MIQACVILRHHGNGLVTAHTLAP
.
MUL_1989|M.ulcerans_Agy99 RGRSVIIDGNTLDPALQLMLSGMRVVGLDGLVIDDDLAA---SRAHMREA
Mvan_2162|M.vanbaalenii_PYR-1 GGRSITIDGNTLDTTLHLMLAGQQLLGLDGLVADDDFVA---ARTQLELL
MAV_3032|M.avium_104 FG----------------ETAPMRQRGLPAVRAGLESAP---RPATMPEM
Mb3111|M.bovis_AF2122/97 NVIR----------------SVLRGARPLFASRRLGIAG---RRVLLATL
Rv3084|M.tuberculosis_H37Rv NVIR----------------SVLRGARPLFASRRLGIAG---RRVLLATL
MAB_2076|M.abscessus_ATCC_1997 MSSR----------------TTLRPLAQLMPSNAYGLAV---MDRVLRTA
MMAR_3137|M.marinum_M MTSR----------------NTLRPLSQLIPSSAHGLAV---MDRVLRMA
Mflv_4606|M.gilvum_PYR-GCK ATAR----------------RVLRPLTQVIPANDHGFAV---MDRVLRGT
MLBr_00314|M.leprae_Br4923 LTSR----------------LTIRPILAVG-SYVPQLPW---PFGLIDHA
TH_1370|M.thermoresistible__bu LAAY----------------LTVRPTLAIG-SFAPRLPW---PWGLLDFA
MSMEG_3010|M.smegmatis_MC2_155 MSIN----------------QPNDPLGVIYAEWTEEFVANPDMSLRLMRW
:
MUL_1989|M.ulcerans_Agy99 MLGFPGPQIHVDVEELTLPGPAGDISARHYRPPGDAAAPLLVFYHGGGWA
Mvan_2162|M.vanbaalenii_PYR-1 AASFKQRIPIAGVTDLTVSGAEGPVKARHYR-TDEPGAPLLVFYHGGGHV
MAV_3032|M.avium_104 AS----------VTEALVPSAAGGIPVRIYRPTTDSGVAVLVYLHGGGLV
Mb3111|M.bovis_AF2122/97 TAGARAPKGTRFQRVSIAGVPVQR-----VQPPHAATSGTLIYLHGGAYA
Rv3084|M.tuberculosis_H37Rv TAGARAPKGTRFQRVSIAGVPVQR-----VQPPHAATSGTLIYLHGGAYA
MAB_2076|M.abscessus_ATCC_1997 LVASRPRRGVTVRKVDTVFAGGPVRGDWITTPAINPHANPLLYIHGGAYS
MMAR_3137|M.marinum_M LVGSRPRRSVAVRTIDTEFAGNQIRGDWITSPAVDPHAVPLLYIHGGAYS
Mflv_4606|M.gilvum_PYR-GCK LVVSRPRRAISVEKVDTPFAGERVRGDWVKAANVASDAPPILYIHGGAFS
MLBr_00314|M.leprae_Br4923 ARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADG-SGRIVLYLHGGAFL
TH_1370|M.thermoresistible__bu ARAVRPVPGTVRATIRLPHCTAQLVRAPGVLPADG-RRSVVLYLHGGAFL
MSMEG_3010|M.smegmatis_MC2_155 VFEDWQRVTSEPEDVTYASTRIGGVPGILVKPLDADPGQMLVVLHGGGFA
:: ***.
MUL_1989|M.ulcerans_Agy99 LGDLDTHDAVCRLTCRDAGIHVLAIDYRLSPEHRAPAAIDDAFAAFEWAH
Mvan_2162|M.vanbaalenii_PYR-1 IGSIDSHDDLCREICRSGGVHVLSVDYRLAPEHPAPAAVEDSYAAYLWAC
MAV_3032|M.avium_104 MGSNRSFEPLARELASASAATVVAVDYRLAPESPPPAQFDDAYAATEWVS
Mb3111|M.bovis_AF2122/97 LGSARGYRGLAAQLAAAAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLL
Rv3084|M.tuberculosis_H37Rv LGSARGYRGLAAQLAAAAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLL
MAB_2076|M.abscessus_ATCC_1997 MCSPETHRGLLGELASASGRPIFAVKYRLAPRYPYPAAADDALNAYRWLT
MMAR_3137|M.marinum_M MCSPATHRGLLGELASASGRPIFAVRYRLAPRYPFPAAADDALNAYRWLV
Mflv_4606|M.gilvum_PYR-GCK MCSPETHRGLISELSAAARRPVFAVRYRLVPRYPFPAAADDALIAYRWLT
MLBr_00314|M.leprae_Br4923 GCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLR
TH_1370|M.thermoresistible__bu TCGAHTHGRLVTALSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLR
MSMEG_3010|M.smegmatis_MC2_155 LGSSASHRKLAGHLARAFGAHAFVADFRLAPEHPYPAQIDDATAVFTSLL
. . : . . : *. ::
MUL_1989|M.ulcerans_Agy99 AHAAELGALPGRVAVGGDSAGGNLAAVVSQLARDSGGPAPIFQWLIYPRT
Mvan_2162|M.vanbaalenii_PYR-1 EHAAELGADPQRVAVGGDSAGGNLAALVTLRARDEKAPRPALQLLLYPVT
MAV_3032|M.avium_104 RKAGELGVDADRLAVIGDSAGGSLAAAVALAARDRRGPPICAQVLLYPGL
Mb3111|M.bovis_AF2122/97 D----DGLDPKTTVIAGDSAGGGLTLALAMALRDRGIQAPAALGLICPWA
Rv3084|M.tuberculosis_H37Rv D----DGLDPKTTVIAGDSAGGGLTLALAMALRDRGIQAPAALGLICPWA
MAB_2076|M.abscessus_ATCC_1997 SGG-SPGSCQRTVAVAGDSAGGQLTMATALGARAVGLPLPDAMLLMSPVL
MMAR_3137|M.marinum_M TGQ-PSASGERGVAVAGDSAGGQLTMATALGARSDGLPLPDSMLLMSPVL
Mflv_4606|M.gilvum_PYR-GCK EGS-AITASSGTVALAGDSAGGQLAAATALGAREHRLPTPDAMLLMSPVL
MLBr_00314|M.leprae_Br4923 ----RLGYDPEQIVLAGDSAGGYLALALAQRLQDVGE-EPAALVAISPLL
TH_1370|M.thermoresistible__bu ----AKGYEPDQIVLAGDSAGGYLALSLAQRLLDEGE-EPAALVALSPLF
MSMEG_3010|M.smegmatis_MC2_155 DN----GIDASSITFVGDSAGASIAVATTLRLLRDGAPVPGRVITISPWL
.. *****. :: : : *
MUL_1989|M.ulcerans_Agy99 DFAGRTR-SASLFARGFLLTKRDIDWFHSQYLKGSGIE---PTDPRVSPL
Mvan_2162|M.vanbaalenii_PYR-1 HYDAETR-SRTLFARGFFLTQHDIDWFRARYLGGAQLE---GSDPRVSPL
MAV_3032|M.avium_104 DRDMSVA-SIAAMPDAPLLIRDDIDYMHALVDGDAGP----PTDPYLVPA
Mb3111|M.bovis_AF2122/97 DLAVDIEATRPALR-DPLILPSMCTEWAPRYVGSSDP------RLPGISP
Rv3084|M.tuberculosis_H37Rv DLAVDIEATRPALR-DPLILPSMCTEWAPRYVGSSDP------RLPGISP
MAB_2076|M.abscessus_ATCC_1997 DLRCELARAREIRRRDPFASAQSAARALDLYVGGADR------GDPRLSV
MMAR_3137|M.marinum_M DLTCELARARELRRRDPFASARSAARALDLYVAGADH------RNERISV
Mflv_4606|M.gilvum_PYR-GCK DLTCQLAMDRDLRRRDPFASAISASRTIGLYVAGADP------ADPRISV
MLBr_00314|M.leprae_Br4923 QLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEP
TH_1370|M.thermoresistible__bu EIDNESRAQHPNIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEP
MSMEG_3010|M.smegmatis_MC2_155 DMENSGSTIESNDATDFLITREGLQGNIDRYLSGGASP-----TDPLVNP
. : .
MUL_1989|M.ulcerans_Agy99 RAESLAGLAPALIAVAGFDPLRDEGENYATALRAAGTPVDLRAMGSLTHG
Mvan_2162|M.vanbaalenii_PYR-1 LAEDHSGLSPALVVTAGFDPLRDEGRHYADALRAAGTPVDYREYGSLVHG
MAV_3032|M.avium_104 YAADLSGLPPAIVVTAGCDPIRDWGERYADRLRDAGVQTTVTRYPGMYHG
Mb3111|M.bovis_AF2122/97 VYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHD
Rv3084|M.tuberculosis_H37Rv VYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHD
MAB_2076|M.abscessus_ATCC_1997 LDADLTSMPPILIQVGGREMLIDDSRRLAERLQSAGSHVEIQVYRGQIHV
MMAR_3137|M.marinum_M LDADLRSMPPILIQVGGREMLIDDSRHLADRLRSAGSSVEIQVYRGQIHV
Mflv_4606|M.gilvum_PYR-GCK LDADLTDMPPTLIQVGGREMLLDDSRVFAKRLQTAGVSSQLQVFRGQIHV
MLBr_00314|M.leprae_Br4923 LDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHV
TH_1370|M.thermoresistible__bu LDNIEPGLPRTLIHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHV
MSMEG_3010|M.smegmatis_MC2_155 LYADFTGFPRLYITVSDTESLYADATRLAEKARAAGVDVTFEVASGQQHV
.:. : ... : : . . *
MUL_1989|M.ulcerans_Agy99 FLNLFPLGGGCAAATSELISALRAHLTRV----------------
Mvan_2162|M.vanbaalenii_PYR-1 FANFFPLGGASATATGDVISAMRAHLTRAG---------------
MAV_3032|M.avium_104 FLMRSDATARGRLAIAEIGGLLRAKFTHPLRFDVPITGRHSTPTR
Mb3111|M.bovis_AF2122/97 FHLQVSLLPEARDAIADLGARLRGHLHQSQGQPRGVVK-------
Rv3084|M.tuberculosis_H37Rv FHLQVSLLPEARDAIADLGARLRGHLHQSQGQPRGVVK-------
MAB_2076|M.abscessus_ATCC_1997 FQAMFRILPEARDAIHRAGRFLEASEVR-----------------
MMAR_3137|M.marinum_M FQAMFRILPEAREAIHRAGNFLKASAHR-----------------
Mflv_4606|M.gilvum_PYR-GCK FQAMFRLLPEAREALRLGGEFLATSATVR----------------
MLBr_00314|M.leprae_Br4923 FQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL--------
TH_1370|M.thermoresistible__bu FQIAAPFVPEAKRSLRQIGEYIREATW------------------
MSMEG_3010|M.smegmatis_MC2_155 FPLQAGVLPEADAAIESMAAWYRSAKPLAV---------------
* :