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TDPAHKPTFGDTVTIETVGSDSAVQRSSHAVARALLRPTLELLARIAARHPTARTHGFRAANFIELAAYP LRPSRDTRRRIVMFEQFRAEWLWHKDLPDPDQAAQGAILYFHGGAFILGGLHSHRRMAARLARASGIPVL VVDYRQLPLAHITDSITDAVDSYRYLLDRGYAPGKIVFAGDSAGGGLAFSAALAARDEGLPVPGGIAAIS PWADLDCSAKRAHPNEAHDAMLSGFILSVPGELGMARGNGLDPAWSAVNHDFHGMPAIFIQVGSLEVLRV DVDLLARRCAEAHVPCTVQVWKHAIHDFQLGADLLPDARAAVGDMAHFIYRITDPDNLKAGTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0141c | - | - | 100% (344) | putative esterase |
| M. abscessus ATCC 19977 | MAB_4044c | - | 4e-48 | 36.28% (317) | putative hydrolase/esterase/lipase |
| M. abscessus ATCC 19977 | MAB_0846 | - | 2e-44 | 40.39% (255) | putative lipase/esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1105 | lipU | 2e-36 | 36.23% (276) | putative lipase LIPU |
| M. gilvum PYR-GCK | Mflv_2042 | - | 1e-34 | 32.03% (281) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1076 | lipU | 2e-36 | 36.23% (276) | lipase LipU |
| M. leprae Br4923 | MLBr_00314 | - | 4e-35 | 36.25% (240) | putative esterase |
| M. marinum M | MMAR_4391 | lipU | 6e-38 | 33.23% (337) | lipase LipU |
| M. avium 104 | MAV_3011 | - | 2e-42 | 37.89% (256) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0267 | - | 2e-40 | 40.93% (237) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 8e-36 | 33.33% (276) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 1e-37 | 37.45% (243) | lipase LipU_1 |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 2e-35 | 32.98% (282) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4391|M.marinum_M ---MTAPSRVPSNPIHAIRPRDVLKARRLEARRFAISDGAPVEVVESGPS
MLBr_00314|M.leprae_Br4923 ---------------------------------MAISAGAPVEIVESGPS
MUL_2832|M.ulcerans_Agy99 MSGVTTFDKLFGPPYDAIRPRRNRRVG----RRAASGHGAHVEVVESGPS
Mflv_2042|M.gilvum_PYR-GCK ---MTAPSKVPATPHVAINAARGRKQ-----RRFPVSDGAPVEVVEDGPS
Mvan_4675|M.vanbaalenii_PYR-1 ---MTAPSKVPATPHAAIAAARAGKI-----RRFPVSDGAPVEVVEDGPS
TH_1370|M.thermoresistible__bu ---MTAPSKVPRTSPLATRAARGHYS-----RTFPVSDGTPSEYVEDGPS
MAV_3011|M.avium_104 -------------------------------------MATTRRVHHR-HS
MSMEG_0267|M.smegmatis_MC2_155 ----------MTSSVSTIDAR--------------PDLSVGKQIMHRRRS
MAB_0141c|M.abscessus_ATCC_199 ----------MTDPAHKPTFG---------DTVTIETVGSDSAVQRSSHA
Mb1105|M.bovis_AF2122/97 -----------MAVRPVLAVGSYLPHAPWPWGVID-QAARVLLPASTTVR
Rv1076|M.tuberculosis_H37Rv -----------MAVRPVLAVGSYLPHAPWPWGVID-QAARVLLPASTTVR
MMAR_4391|M.marinum_M VAARVATLASRLTIRPVLAVGSHVPHLPWPWGLID-HAAKALVPASATVR
MLBr_00314|M.leprae_Br4923 IAARLASLTSRLTIRPILAVGSYVPQLPWPFGLID-HAARVLLPVTNAAR
MUL_2832|M.ulcerans_Agy99 IAARVVSLASRLTVRPVIAVASHFPHLPWPWSLVD-FALLPITWASGIIG
Mflv_2042|M.gilvum_PYR-GCK VAGRVLGLAAMATIKPFLTVGSYAPKLPWPWGLVD-FAARVLKPAPGTVR
Mvan_4675|M.vanbaalenii_PYR-1 IAGRLMGLAAVATVKPFLTVGSYAPKLPWPWGLLD-FAARVLKPAPGTVR
TH_1370|M.thermoresistible__bu LAGRLTALAAYLTVRPTLAIGSFAPRLPWPWGLLD-FAARAVRPVPGTVR
MAV_3011|M.avium_104 PQSVAVSLASRLIVKNAVRAWALTPNLHWPLEYVDSFAGLVPRLGSAGTT
MSMEG_0267|M.smegmatis_MC2_155 AESFALAAGCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHR-VDAKI
MAB_0141c|M.abscessus_ATCC_199 VARALLRPTLELLARIAARHPTARTHGFRAANFIE-LAAYPLRPSRDTRR
: : .. . :: .
Mb1105|M.bovis_AF2122/97 AAVSLPNASAQLVRASGVLPAD-GTRRAVLYLHGGAFLTCGANSHGRLVE
Rv1076|M.tuberculosis_H37Rv AAVSLPNASAQLVRASGVLPAD-GTRRAVLYLHGGAFLTCGANSHGRLVE
MMAR_4391|M.marinum_M AAVSLPNAAAQLVRAPGVLPAD-GTRRVVLYLHGGAFLTCGANSHGRLVE
MLBr_00314|M.leprae_Br4923 AEVNLSNTSAQLVRAAGVRPAD-GSGRIVLYLHGGAFLGCGANSHRRLVE
MUL_2832|M.ulcerans_Agy99 ERVSLPNASGHLVRASGVPPPD-GSRRVVLYMHGGAFLKGGIHSHARLAG
Mflv_2042|M.gilvum_PYR-GCK ATIKLPHCTAQLVRAAGVLPAD-GNRTVILYLHGGAFLTCGVNTHGRLVT
Mvan_4675|M.vanbaalenii_PYR-1 ATIGLPHCNAQLVRAAGVLPAD-GHRSVILYLHGGAFLTCGVNTHGRLVT
TH_1370|M.thermoresistible__bu ATIRLPHCTAQLVRAPGVLPAD-GRRSVVLYLHGGAFLTCGAHTHGRLVT
MAV_3011|M.avium_104 HPVRLEHCAAEWVRAPGVS-----GERAILYLHGGAFLTCGLNTHRPMVT
MSMEG_0267|M.smegmatis_MC2_155 RSVQLPDCAAELVCANGVS-----ADRAILYLHGGAFMTCGINTHRSLVA
MAB_0141c|M.abscessus_ATCC_199 RIVMFEQFRAEWLWHKDLPDPDQAAQGAILYFHGGAFILGGLHSHRRMAA
: : . .. : .: :**:*****: * ::* :.
Mb1105|M.bovis_AF2122/97 LLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLA
Rv1076|M.tuberculosis_H37Rv LLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLA
MMAR_4391|M.marinum_M LLSKFADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLA
MLBr_00314|M.leprae_Br4923 TLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQIVLA
MUL_2832|M.ulcerans_Agy99 TLSKFADSPLLVVNYRLVPKHTVGMALEDCHDAYLWLRLRGHAPEQIVLA
Mflv_2042|M.gilvum_PYR-GCK ALSKCADAPALVVNYRMIPKHSVGTALDDCYDAYKWLRETGYEPEQIVLA
Mvan_4675|M.vanbaalenii_PYR-1 ALSKCADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPDQIVLA
TH_1370|M.thermoresistible__bu ALSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQIVLA
MAV_3011|M.avium_104 RLSKAADAAVLAVAYRKLPAHQITDAIDDGLDGLRWLQDRGFDGDRVVVA
MSMEG_0267|M.smegmatis_MC2_155 RLSREADAAVLNVGYRMLPKYGLAEAIDDAVAGLRWLQEQGYTSDQIVIA
MAB_0141c|M.abscessus_ATCC_199 RLARASGIPVLVVDYRQLPLAHITDSITDAVDSYRYLLDRGYAPGKIVFA
*:. :. . * * ** :* : :: * . :* *. ::*.*
Mb1105|M.bovis_AF2122/97 GDSAGGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQAHP
Rv1076|M.tuberculosis_H37Rv GDSAGGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQAHP
MMAR_4391|M.marinum_M GDSAGGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHP
MLBr_00314|M.leprae_Br4923 GDSAGGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQAHP
MUL_2832|M.ulcerans_Agy99 GDSAGGYLAFALAQRLRAR------GEEPAALVAISPLLQLAMRSKKAHP
Mflv_2042|M.gilvum_PYR-GCK GDSAGGYLALALAEKLQAEGINGYVGETPAAVVTMSPLFEIDNEARADHP
Mvan_4675|M.vanbaalenii_PYR-1 GDSAGGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARADHP
TH_1370|M.thermoresistible__bu GDSAGGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRAQHP
MAV_3011|M.avium_104 GDSAGGYLAFMTTLLAIQNE-----VMEPAGIATVSPFTDTDPARKLKHR
MSMEG_0267|M.smegmatis_MC2_155 GDSAGGYLALATALQLSSRG-----EVPAAGIAAISPLTDLDPASKLEHP
MAB_0141c|M.abscessus_ATCC_199 GDSAGGGLAFSAALAARDEG-----LPVPGGIAAISPWADLDCSAKRAHP
****** **: : ...:.::** : : *
Mb1105|M.bovis_AF2122/97 NIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRT
Rv1076|M.tuberculosis_H37Rv NIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRT
MMAR_4391|M.marinum_M NIKRDAMFPPKAFDALGELVASAAAKNKIDGKPEELYEPLEHIRPGLPRT
MLBr_00314|M.leprae_Br4923 NAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRT
MUL_2832|M.ulcerans_Agy99 NIKSDAMFPARAFDALVAIVAGAAARNETAGRREEIYEPLEHIAPGLPPT
Mflv_2042|M.gilvum_PYR-GCK NVRTDSMFPPKAFHALVELIEEAAARRMVNGAPEEVYEPLDHIEPGLPRT
Mvan_4675|M.vanbaalenii_PYR-1 NVRTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRT
TH_1370|M.thermoresistible__bu NIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRT
MAV_3011|M.avium_104 NARKCSMFTCRAFSRFAEYLS--NAQVLEGHGDSTVASPVDADLSSLPPV
MSMEG_0267|M.smegmatis_MC2_155 NARKCAMFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKLPPV
MAB_0141c|M.abscessus_ATCC_199 NEAHDAMLSG------FILSVPGELGMARGNGLDPAWSAVNHDFHGMPAI
* :*:. ..: :*
Mb1105|M.bovis_AF2122/97 LIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEA
Rv1076|M.tuberculosis_H37Rv LIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEA
MMAR_4391|M.marinum_M LIHVSGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEA
MLBr_00314|M.leprae_Br4923 LIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEA
MUL_2832|M.ulcerans_Agy99 LIHVSGAEALLHDARLAAGKLAAAGVRAEVRVWPGQLHDFQVAAPMLPEA
Mflv_2042|M.gilvum_PYR-GCK LIHVSGSEVLLSDARKAARLLAASGVPVEVRIWPGQMHVFQLGAPMVPEA
Mvan_4675|M.vanbaalenii_PYR-1 LIHVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEA
TH_1370|M.thermoresistible__bu LIHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEA
MAV_3011|M.avium_104 TIHASSDELLVADAELMAKRLEASGIHCDLHLWDGQIHDFPLAADVLPEG
MSMEG_0267|M.smegmatis_MC2_155 TVHVSADESLYSDSELLAGRLAEAQVPCELHVWHGQVHDFPLAADILPEG
MAB_0141c|M.abscessus_ATCC_199 FIQVGSLEVLRVDVDLLARRCAEAHVPCTVQVWKHAIHDFQLGADLLPDA
::... * * * * : :::* :* * .. :.:.
Mb1105|M.bovis_AF2122/97 IRSLRQIGEYIREATG-----------------
Rv1076|M.tuberculosis_H37Rv IRSLRQIGEYIREATG-----------------
MMAR_4391|M.marinum_M TRSLRQIGDYIREATG-----------------
MLBr_00314|M.leprae_Br4923 TLSLRQISQYIREATASKASRDRQSL-------
MUL_2832|M.ulcerans_Agy99 TYSLRQIGEYIRQATG-----------------
Mflv_2042|M.gilvum_PYR-GCK SRSIKQIGEYIREATW-----------------
Mvan_4675|M.vanbaalenii_PYR-1 NRSIKQIGEYIREATW-----------------
TH_1370|M.thermoresistible__bu KRSLRQIGEYIREATW-----------------
MAV_3011|M.avium_104 RRAIKYLGDFVKDVTAAGTRFSNVRRLRTAAAG
MSMEG_0267|M.smegmatis_MC2_155 RRALRYVGDFVKQTT--GTRLANVS--------
MAB_0141c|M.abscessus_ATCC_199 RAAVGDMAHFIYRITDPDNLKAGTP--------
:: :..:: *