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TVNPATLDAVLQKVLEAVPFKLTTEGGPEPARQRFKELPRNAILPEVAAQDLSIEGPAGPVPVRIYRPPS DEAAPPTVVFIHGGGWTVGDLDSYDGTARLHAAGAGAVVVSVDYRLAPEHPYPAAVDDVWAATRWVAENA AELGADPDRLAVAGDSAGGNLAAVVAQSARDAGIPLRFQLLWYPSTTFDTSLPSFVENAQAPILDLAACK GFTRWYIGDTDLSEPPVTLVPARGNLAGLPPAYIAVAGHDPLRDDGLRYGELLTAAGVPVELHHAESLVH GYLGYAGIVPAATEATERGLAALRAALA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2672 | - | - | 100% (309) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2162 | - | 1e-53 | 45.32% (267) | alpha/beta hydrolase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2888 | - | 2e-49 | 43.75% (288) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1435c | lipI | 1e-115 | 64.59% (305) | lipase LipH |
| M. gilvum PYR-GCK | Mflv_3735 | - | 1e-147 | 80.65% (310) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1400c | lipI | 1e-115 | 64.59% (305) | lipase LipH |
| M. leprae Br4923 | MLBr_00314 | - | 1e-16 | 28.16% (245) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2814 | - | 6e-98 | 57.52% (306) | lipase LipH |
| M. marinum M | MMAR_2209 | lipI | 1e-112 | 62.78% (309) | lipase LipI |
| M. avium 104 | MAV_3377 | - | 1e-116 | 65.50% (313) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3059 | - | 1e-120 | 72.35% (293) | esterase |
| M. thermoresistible (build 8) | TH_3304 | - | 3e-73 | 71.96% (189) | PUTATIVE esterase |
| M. ulcerans Agy99 | MUL_1795 | lipI | 1e-112 | 62.78% (309) | lipase LipI |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2672|M.vanbaalenii_PYR-1 ------MTVNPATLDAVLQKVLEAVPFKLTTEGGPEPARQRFKELP--RN
Mflv_3735|M.gilvum_PYR-GCK --------MGMAALDPVLQTVLDAVPFQLTTDGGPEAARRRFRDLP--RS
Mb1435c|M.bovis_AF2122/97 MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDLP--RQ
Rv1400c|M.tuberculosis_H37Rv MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDLP--RQ
MMAR_2209|M.marinum_M MPSLDKTADEKPAIDPIMQKVLDAVPFRLSTEDGIDAVRQRLRDLP--RR
MUL_1795|M.ulcerans_Agy99 MPSLDKTADEKPAIDPIMQKVLDAVPFRLSTEDGIDAVRQRLRDLP--RR
MAV_3377|M.avium_104 MPRLDNPADEKPGIDPILQKVLDAVPFRLSTEDGIDAARQRFRDLP--RR
MSMEG_3059|M.smegmatis_MC2_155 ------------------------MPFQLSTADGVEEARRKFSELP--RA
TH_3304|M.thermoresistible__bu --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 -------MTATAGIDPIIVKILEAVPIQLVSPDGPQASRDAYRAIATARP
MLBr_00314|M.leprae_Br4923 MAISAGAPVEIVESGPSIAARLASLTSRLTIRP-ILAVGSYVPQLPWPFG
Mvan_2672|M.vanbaalenii_PYR-1 AILPEVAAQDLSIEGPAGPVPVR-----IYRPPSD---EAAPPTVVFIHG
Mflv_3735|M.gilvum_PYR-GCK PVHPDVETQDRAIDGPAGPIALR-----IYRPPTE---QSVLPVVVFLHG
Mb1435c|M.bovis_AF2122/97 PVHPELRVVDLAIDGPAGPIGTR-----IYWPPTCPDQAE-APVVLYFHG
Rv1400c|M.tuberculosis_H37Rv PVHPELRVVDLAIDGPAGPIGTR-----IYWPPTCPDQAE-APVVLYFHG
MMAR_2209|M.marinum_M PVHPELRVEDRAIDGPGGSIPIR-----IYWPPISPDATDPLPVVLFFHG
MUL_1795|M.ulcerans_Agy99 PVHPELRVEDRAIDGPGGSIPIR-----IYWPPISPDATDPLPVVLFFHG
MAV_3377|M.avium_104 PLHPELRVEDRTIPGPQGAIAVR-----IYWPPIHSESRP-APVVLYFHG
MSMEG_3059|M.smegmatis_MC2_155 EIHPELSVHDRTIEGPAGPIGVR-----VYRPPTAEG--VKLPVVLFFHG
TH_3304|M.thermoresistible__bu --------------------------------------------------
MAB_2814|M.abscessus_ATCC_1997 PWIEVANIEDRTIPGPAGEIPVR-----IYSPAEG----GVRPVFVLIHG
MLBr_00314|M.leprae_Br4923 LIDHAARVLLPVTNAARAEVNLSNTSAQLVRAAGVRPADGSGRIVLYLHG
Mvan_2672|M.vanbaalenii_PYR-1 GGWTVGDLDSYDGTARLHAAGAGAVVVSVDYRLAPEHPYPAAVDDVWAAT
Mflv_3735|M.gilvum_PYR-GCK GGWTVGDLDTYDGQARMHAAGAGAVVVSVDYRLAPEHPYPAAVEDVWAAT
Mb1435c|M.bovis_AF2122/97 GGFVMGDLDTHDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAAT
Rv1400c|M.tuberculosis_H37Rv GGFVMGDLDTHDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAAT
MMAR_2209|M.marinum_M GGFVMGDLDTHDGTCRQHAVGADTLVVSVDYRLAPEHPYPAAIQDAWAAT
MUL_1795|M.ulcerans_Agy99 GGFVMGDLDTHDGTCRQHAVGADTLVVSVDYRLAPEHPYPAAIQDAWAAT
MAV_3377|M.avium_104 GGFVIGDLDTHDGTARQHAVGAGAIVVSVDYRLAPEHPYPAAVEDAWAAT
MSMEG_3059|M.smegmatis_MC2_155 GGWSVGDLDSYDATARRHAAGAEAVVVSVDYRLAPEHPYPAAVDDVWAAT
TH_3304|M.thermoresistible__bu ------------------------------------------VEDCWAAV
MAB_2814|M.abscessus_ATCC_1997 GGWVIGDLDTHDAVARAAAVQADAVVVSVDYRLAPEHPYPAAVEDCWAAL
MLBr_00314|M.leprae_Br4923 GAFLGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGY
::* .
Mvan_2672|M.vanbaalenii_PYR-1 RWVAENAAELGADPDRLAVAGDSAGGNLAAVVAQSARDAGI------PLR
Mflv_3735|M.gilvum_PYR-GCK RWVADNADQIGADADRVAVAGDSAGGNLAAVTAQSARDAGI------ALR
Mb1435c|M.bovis_AF2122/97 RWVAEHGRQVGADLGRIAVAGDSAGGTIAAVIAQRARDMGG-----PPIV
Rv1400c|M.tuberculosis_H37Rv RWVAEHGRQVGADLGRIAVAGDSAGGTIAAVIAQRARDMGG-----PPIV
MMAR_2209|M.marinum_M RWVADHGSTIGADLNRVAVAGDSAGGTIAAVIAQQARDNADG--PIPPIA
MUL_1795|M.ulcerans_Agy99 RWVADHRSTIGADLNRVAVAGDSAGGTIAAVIAQQARDNADG--PIPPIA
MAV_3377|M.avium_104 LWAAENAAGLHGDPGRIAVAGDSAGGTLAAVTAQRARDRGG-----PPVR
MSMEG_3059|M.smegmatis_MC2_155 QWVAAHAEELGGDAERLAVAGDSAGGNLAAVVAQLARDAG-----APALR
TH_3304|M.thermoresistible__bu RWTAAHAAELGGDPARIAVAGDSAGGNLSAVMALLDRDHARADGSAPILR
MAB_2814|M.abscessus_ATCC_1997 QWVHEHAAEIGGDPGRLAVGGDSAGGNLSAVMAQLARDNGID------LA
MLBr_00314|M.leprae_Br4923 QWLRR----LGYDPEQIVLAGDSAGGYLALALAQRLQDVGEE--PAALVA
* : * ::.:.****** :: . * :* . :
Mvan_2672|M.vanbaalenii_PYR-1 FQLLWYPSTTFDTSLPSFVENAQAPILDLAACKGFTRWYIGDTDLSEP--
Mflv_3735|M.gilvum_PYR-GCK FQLLWYPSTTFDTSLPSFRENADAPILDLASCKGFSRWYVGDLDLSGPSG
Mb1435c|M.bovis_AF2122/97 FQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAFSRWYAGEIDLHNP--
Rv1400c|M.tuberculosis_H37Rv FQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAFSRWYAGEIDLHNP--
MMAR_2209|M.marinum_M FQLLWYPSTMWDQTLPSFTENATGEVLDVKAIADFSRWYAGDTDLSNP--
MUL_1795|M.ulcerans_Agy99 FQLLWYPSTMWDQTLPSFTENATGEVLDVKAIADFSRWYAGDTDLSNP--
MAV_3377|M.avium_104 FQLLWYPSTMWDASLPSFAENATAPILDVKAVAEFSRWYAGDVDLSDP--
MSMEG_3059|M.smegmatis_MC2_155 MQLLWYPATTWDTSLPSFAENADAPVLAIDAVKGFSAWYAGHVDLTDP--
TH_3304|M.thermoresistible__bu FQLLWYPATTWDTSLPSFSENADAPVLGLDAVAGLSRWYAGHVDLSDP--
MAB_2814|M.abscessus_ATCC_1997 FQVLWYPATTFDTTLPSMVENAEAPVLDFKTVGALSKWYLGDTNPATAG-
MLBr_00314|M.leprae_Br4923 ISPLLQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDK--
:. * :. . : *. :* . : : .. .
Mvan_2672|M.vanbaalenii_PYR-1 -PVTLVPARGN-LAGLPPAYIAVAGHDPLRDDGLRYGELLTAAGVPVELH
Mflv_3735|M.gilvum_PYR-GCK PPVTLVPARGD-LTGLPPAYIAVAGHDPLRDDGVRYAELLTAAGVPVELH
Mb1435c|M.bovis_AF2122/97 -PAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPVEVH
Rv1400c|M.tuberculosis_H37Rv -PAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPVEVH
MMAR_2209|M.marinum_M -PAGMAPGRAENLANLPAAYIAVAGHDPLRDDGIRYGELLAAAGVSVEVH
MUL_1795|M.ulcerans_Agy99 -PAGMAPGRAENLANLPAAYIAVAGHDPLRDDGIRYGELLAAAGVSVEVH
MAV_3377|M.avium_104 -PADMAPGRATDLSNLPPAYIGVAGYDPLRDDGIRYGERLAAAGVAAQVH
MSMEG_3059|M.smegmatis_MC2_155 -PATLVPARHDDLSGLAPAYIAVAGHDPLRDDGVHYGDLLAAAGVPVQLD
TH_3304|M.thermoresistible__bu -PVTLVPARADDLSGLPPAYIAVAGHDPLRDDGAKYAELLTAAGVPVELH
MAB_2814|M.abscessus_ATCC_1997 --PTLVPARAENFEGLAPAFIGTAQFDPLRDDGAKYAELLRDAGVPVQLH
MLBr_00314|M.leprae_Br4923 -PEELYEPLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIR
: .*. : * .: : * .*. . * .**..::
Mvan_2672|M.vanbaalenii_PYR-1 HAESLVHGYLGYAGIVPAATEATERGLAALRAALA----------
Mflv_3735|M.gilvum_PYR-GCK HAESLVHGYLGYAGIVPAATEATERGLEALRAALA----------
Mb1435c|M.bovis_AF2122/97 NAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG---------
Rv1400c|M.tuberculosis_H37Rv NAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG---------
MMAR_2209|M.marinum_M NAGSLVHGYIGYAGVVPAATTAMERGLAALRVALHG---------
MUL_1795|M.ulcerans_Agy99 NAGSLVHGYIGYAGVVPAATTAMERGLAALRIALHG---------
MAV_3377|M.avium_104 NAETLVHGYLGYAGVVPAATAAMERGLVALRTALQG---------
MSMEG_3059|M.smegmatis_MC2_155 NADTLVHGYLGYSGVVPAATEAFDRGLAALREALHS---------
TH_3304|M.thermoresistible__bu NADTLVHGYLGYSGVVPAATEATERALKALRAALHGPGSAS----
MAB_2814|M.abscessus_ATCC_1997 NAPTLIHGYLGYADIVPSATEERDLSLAALKQALHG---------
MLBr_00314|M.leprae_Br4923 VWPGQVHVFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL
:* : . : :** ** :: .