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AALASRMTIKPLMTVGSYLSPLPLPLGFVDFACRVWRPGQGTVRTTINLPNATAQLVRAPGVRAADGAGR VVLYLHGGAFVMCGPNSHSRIVNALSGFAESPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQI VLAGDSAGGYLALALAQRLQCDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAA AAKNMVDGRPEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLA TPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3487c | lipF | - | 100% (277) | PROBABLE ESTERASE/LIPASE LIPF |
| M. tuberculosis H37Rv | Rv1076 | lipU | e-104 | 76.42% (246) | lipase LipU |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | 7e-33 | 35.43% (254) | putative acetyl hydrolase MBTJ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3517c | lipF | 1e-159 | 100.00% (277) | esterase/lipase LipF |
| M. gilvum PYR-GCK | Mflv_2042 | - | 1e-89 | 62.30% (252) | alpha/beta hydrolase domain-containing protein |
| M. leprae Br4923 | MLBr_00314 | - | 1e-104 | 73.60% (250) | putative esterase |
| M. abscessus ATCC 19977 | MAB_1194 | - | 5e-70 | 54.07% (246) | putative lipase LipU |
| M. marinum M | MMAR_4391 | lipU | 1e-103 | 74.80% (246) | lipase LipU |
| M. avium 104 | MAV_1200 | - | 1e-105 | 76.02% (246) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5271 | - | 1e-84 | 62.60% (246) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 3e-93 | 65.85% (246) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_0204 | lipU | 1e-102 | 74.80% (246) | lipase LipU |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 3e-89 | 63.49% (252) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2042|M.gilvum_PYR-GCK ---MTAPSKVPATPHVAINAARGRKQR-----RFPVSDGAPVEVVEDGPS
Mvan_4675|M.vanbaalenii_PYR-1 ---MTAPSKVPATPHAAIAAARAGKIR-----RFPVSDGAPVEVVEDGPS
TH_1370|M.thermoresistible__bu ---MTAPSKVPRTSPLATRAARGHYSR-----TFPVSDGTPSEYVEDGPS
MSMEG_5271|M.smegmatis_MC2_155 MVAMTAPSKVTRSPRAGIGPGGAYRTR-----KFPVSDSAPVEIVEDGTS
Rv3487c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3517c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4391|M.marinum_M ---MTAPSRVPSNPIHAIRPRDVLKARRLEARRFAISDGAPVEVVESGPS
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
MAV_1200|M.avium_104 ---MTAPSEVSGSQS-PVRVHDVLKARRARIRKFAISDGAPVEVLESGPS
MLBr_00314|M.leprae_Br4923 ---------------------------------MAISAGAPVEIVESGPS
MAB_1194|M.abscessus_ATCC_1997 ---MTAPKRAPEYGPAGSARSSLSAVN-TLVRGLPLSDGAAVEVIEDAAS
Mflv_2042|M.gilvum_PYR-GCK VAGRVLGLAAMATIKPFLTVGSYAPKLPWPWGLVDFAARVLKPAPGTVRA
Mvan_4675|M.vanbaalenii_PYR-1 IAGRLMGLAAVATVKPFLTVGSYAPKLPWPWGLLDFAARVLKPAPGTVRA
TH_1370|M.thermoresistible__bu LAGRLTALAAYLTVRPTLAIGSFAPRLPWPWGLLDFAARAVRPVPGTVRA
MSMEG_5271|M.smegmatis_MC2_155 VAGRLASLAAMLTIRPTLAIGSRVPHLPWPFGALNFAARMLRPSPGTIKA
Rv3487c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3517c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4391|M.marinum_M VAARVATLASRLTIRPVLAVGSHVPHLPWPWGLIDHAAKALVPASATVRA
MUL_0204|M.ulcerans_Agy99 ----------------MLAVGSHVPHLPWPWGLIDHAAKALVPASATVRA
MAV_1200|M.avium_104 VAARLANLTSRLTIRPILAVGSHAPNLPWPWGLIDLTARVLLPVSATVRE
MLBr_00314|M.leprae_Br4923 IAARLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAARA
MAB_1194|M.abscessus_ATCC_1997 LAGRLLGFGVRMTVRTVLQIGSHAPTFPYPFGLIEELGRVLVPPRGTVKA
Mflv_2042|M.gilvum_PYR-GCK TIKLPHCTAQLVRAAGVLPADGNRTVILYLHGGAFLTCGVNTHGRLVTAL
Mvan_4675|M.vanbaalenii_PYR-1 TIGLPHCNAQLVRAAGVLPADGHRSVILYLHGGAFLTCGVNTHGRLVTAL
TH_1370|M.thermoresistible__bu TIRLPHCTAQLVRAPGVLPADGRRSVVLYLHGGAFLTCGAHTHGRLVTAL
MSMEG_5271|M.smegmatis_MC2_155 TIALPNCTAQLIRADGVLPADGTRSVILYLHGGAFLACGSNTHGGMATSL
Rv3487c|M.tuberculosis_H37Rv -----------MRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNAL
Mb3517c|M.bovis_AF2122/97 -----------MRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNAL
MMAR_4391|M.marinum_M AVSLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRLVELL
MUL_0204|M.ulcerans_Agy99 AVSLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRFFELL
MAV_1200|M.avium_104 TVALPHASAQLVRAPGVLPADGTRRVVVYLHGGAFLTCGANSHGRLVEAL
MLBr_00314|M.leprae_Br4923 EVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVETL
MAB_1194|M.abscessus_ATCC_1997 TVTLPNTNARLIRAKGVGPADGTGRVVLYLHGGAFIVGGPNTHSAMVSTI
:** ** .*** :::*******: * ::* : :
Mflv_2042|M.gilvum_PYR-GCK SKCADAPALVVNYRMIPKHSVGTALDDCYDAYKWLRETGYEPEQIVLAGD
Mvan_4675|M.vanbaalenii_PYR-1 SKCADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPDQIVLAGD
TH_1370|M.thermoresistible__bu SEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQIVLAGD
MSMEG_5271|M.smegmatis_MC2_155 SEYADSPVLVVDYRMVPKHSVGTAVDDCYDAYVWLRRAGYEPEQIVVAGD
Rv3487c|M.tuberculosis_H37Rv SGFAESPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGD
Mb3517c|M.bovis_AF2122/97 SGFAESPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGD
MMAR_4391|M.marinum_M SKFADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGD
MUL_0204|M.ulcerans_Agy99 SKFADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGD
MAV_1200|M.avium_104 STFADAPVLVVNYRLLPKNSVGMALQDCHDAYQWLRLRGYQPDQIVLAGD
MLBr_00314|M.leprae_Br4923 SKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQIVLAGD
MAB_1194|M.abscessus_ATCC_1997 SQHADAPCLVVNYRMPPKASLDQAIDDCLDGYRWLRAQGYAAEQIVLAGD
* *::* *:*:**: ** *:. *::** *.* *** ** .:***:***
Mflv_2042|M.gilvum_PYR-GCK SAGGYLALALAEKLQAEGINGYVGETPAAVVTMSPLFEIDNEARADHPNV
Mvan_4675|M.vanbaalenii_PYR-1 SAGGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARADHPNV
TH_1370|M.thermoresistible__bu SAGGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRAQHPNI
MSMEG_5271|M.smegmatis_MC2_155 SAGGYLGLALAERLLDD------GEVPAALVAMSPLYEIDNRARAEHPNA
Rv3487c|M.tuberculosis_H37Rv SAGGYLALALAQRLQCD------DEKPAAIVAISPLLQLAKGPKQDHPNI
Mb3517c|M.bovis_AF2122/97 SAGGYLALALAQRLQCD------DEKPAAIVAISPLLQLAKGPKQDHPNI
MMAR_4391|M.marinum_M SAGGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHPNI
MUL_0204|M.ulcerans_Agy99 SAGGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHPNI
MAV_1200|M.avium_104 SAGGYLALTLAQRLQRD------GEEPAALVMISPLLQLAKEPKQAHPNI
MLBr_00314|M.leprae_Br4923 SAGGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQAHPNA
MAB_1194|M.abscessus_ATCC_1997 SAGGFLSVAVAERLLAED-----GEAPAALALISPLIELDPAAKVAHENA
****:*.:::*::* .* ***:. :*** :: : * *
Mflv_2042|M.gilvum_PYR-GCK RTDSMFPPKAFHALVELIEEAAARRMVNGAPEEVYEPLDHIEPGLPRTLI
Mvan_4675|M.vanbaalenii_PYR-1 RTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRTLI
TH_1370|M.thermoresistible__bu RTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTLI
MSMEG_5271|M.smegmatis_MC2_155 RRDAMFPPKAFDALVEIVEAAAAR---NG--EQVYEPLDHIEPGLPRTLI
Rv3487c|M.tuberculosis_H37Rv GTDAMFPARAFDALAAWVRAAAAKNMVDGRPEDLYEPLDHIESSLPPTLI
Mb3517c|M.bovis_AF2122/97 GTDAMFPARAFDALAAWVRAAAAKNMVDGRPEDLYEPLDHIESSLPPTLI
MMAR_4391|M.marinum_M KRDAMFPPKAFDALGELVASAAAKNKIDGKPEELYEPLEHIRPGLPRTLI
MUL_0204|M.ulcerans_Agy99 KRDAMFPPKAFDALGELVASAAAKNRVDGKPEELYEPLEHIRPGLPRTLI
MAV_1200|M.avium_104 DTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTLI
MLBr_00314|M.leprae_Br4923 KTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLI
MAB_1194|M.abscessus_ATCC_1997 RTDVMLPPNCFEALEKILTKAGGG-------IPPQEIIDKVDGRMPQTLV
* *: . .* ** : :. * :::: :* **:
Mflv_2042|M.gilvum_PYR-GCK HVSGSEVLLSDARKAARLLAASGVPVEVRIWPGQMHVFQLGAPMVPEASR
Mvan_4675|M.vanbaalenii_PYR-1 HVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEANR
TH_1370|M.thermoresistible__bu HVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEAKR
MSMEG_5271|M.smegmatis_MC2_155 HVSGSEVLISDARKAARMLCAAGVPVEVHVWPGQMHVFQIAGNLVPEAKR
Rv3487c|M.tuberculosis_H37Rv HVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLATPLVPEATR
Mb3517c|M.bovis_AF2122/97 HVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLATPLVPEATR
MMAR_4391|M.marinum_M HVSGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEATR
MUL_0204|M.ulcerans_Agy99 HVSGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEATR
MAV_1200|M.avium_104 HVSGSEVLLHDARLAASRLAAAGVPAEVRVWPGQIHDFQLAAPMVPEARR
MLBr_00314|M.leprae_Br4923 HVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATL
MAB_1194|M.abscessus_ATCC_1997 HCSGSEVLLYDARLLGKRLAEQGVPVEIKIWPGQMHVFQVATKVVPEAKR
* ****.*: **: . *. ** .*:::**** * ** . :.**
Mflv_2042|M.gilvum_PYR-GCK SIKQIGEYIREATW------------------------------
Mvan_4675|M.vanbaalenii_PYR-1 SIKQIGEYIREATW------------------------------
TH_1370|M.thermoresistible__bu SLRQIGEYIREATW------------------------------
MSMEG_5271|M.smegmatis_MC2_155 SLRQIGAYIREATW------------------------------
Rv3487c|M.tuberculosis_H37Rv SLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI
Mb3517c|M.bovis_AF2122/97 SLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI
MMAR_4391|M.marinum_M SLRQIGDYIREATG------------------------------
MUL_0204|M.ulcerans_Agy99 SLRQIGDYIREATG------------------------------
MAV_1200|M.avium_104 SLRQIGDYIREATG------------------------------
MLBr_00314|M.leprae_Br4923 SLRQISQYIREATASKASRDRQSL--------------------
MAB_1194|M.abscessus_ATCC_1997 SLAQIGQYIRDAVPGTFPAEFAAPAAV-----------------
*: **. :**:*.