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IEEQRTMSVEGADQQSEKLFHYLKKVAVELDETRARLREYEQRATEPVAVVGIGCRFPGGVDGPDGLWDV VSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLML EVSWEALEHAGIDPLSLRGSATGVYTGIFAASYGNRDTGGLQGYGLTGTSISVASGRVSYVLGLQGPAVS VDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGE GAGVVVLERLSDARRLGHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVALANAGLSAADVDVVEAH GTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHGVMPATLHVDE PSPRVDWTSGAVSVLTEAREWSVDGRPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVEASESTGGRGR RWCRG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2947c | pks15 | - | 100% (496) | PROBABLE POLYKETIDE SYNTHASE PKS15 |
M. tuberculosis H37Rv | Rv1662 | pks8 | 0.0 | 73.78% (450) | polyketide synthase pks8 |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 71.71% (463) | polyketide synthase pks7 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2971c | pks1 | 0.0 | 99.59% (488) | polyketide synthase PKS1 |
M. gilvum PYR-GCK | Mflv_0405 | - | 1e-133 | 53.03% (445) | beta-ketoacyl synthase |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 90.52% (485) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 1e-136 | 54.05% (444) | polyketide synthase |
M. marinum M | MMAR_1762 | pks15/1 | 0.0 | 84.85% (482) | polyketide synthase Pks15/1 |
M. avium 104 | MAV_3108 | - | 0.0 | 72.16% (467) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 1e-135 | 54.05% (444) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 1e-113 | 48.07% (441) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 84.65% (482) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 1e-136 | 53.44% (451) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK --------------MGSAAHQGE-SAHRFAIVGYAGRFPGARDAESFWEL MAB_0939|M.abscessus_ATCC_1997 --------------MDSAENPIE-STPRFAIIGYAARFPGAADAEEFWDV MSMEG_0408|M.smegmatis_MC2_155 --------------MVSAEHPIE-PTPSFAIIGYAARFPGAASAEEYWAL Mvan_1003|M.vanbaalenii_PYR-1 MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPGAADADEFWDV Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LADGRDAISEVPEDRWDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPF MAB_0939|M.abscessus_ATCC_1997 LREGRDAISEVPADRWDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPF MSMEG_0408|M.smegmatis_MC2_155 LRDGREAISDVPKDRWDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPF Mvan_1003|M.vanbaalenii_PYR-1 LRGGRDAISEVPQDRWDADEFFDADPEAAGKMVTRRAGFVEDVAGFDAPF Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTNTGVFVGLATH MAB_0939|M.abscessus_ATCC_1997 FGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATH MSMEG_0408|M.smegmatis_MC2_155 FGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSNTGVFVGLATH Mvan_1003|M.vanbaalenii_PYR-1 FGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTRTGVFMGLSTH Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS MAB_0939|M.abscessus_ATCC_1997 DYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACS MSMEG_0408|M.smegmatis_MC2_155 DYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS Mvan_1003|M.vanbaalenii_PYR-1 DYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQGPAVAVDTACS Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSNAHMLAPDGRC MAB_0939|M.abscessus_ATCC_1997 SSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFSHAHMLAPDGKC MSMEG_0408|M.smegmatis_MC2_155 SSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSNAHMLAPDGRC Mvan_1003|M.vanbaalenii_PYR-1 SSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSRARMLAPDGRC Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASG MAB_0939|M.abscessus_ATCC_1997 KTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASG MSMEG_0408|M.smegmatis_MC2_155 KTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASG Mvan_1003|M.vanbaalenii_PYR-1 KTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRGSAVNQDGASG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAG MAB_0939|M.abscessus_ATCC_1997 GLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAG MSMEG_0408|M.smegmatis_MC2_155 GLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAG Mvan_1003|M.vanbaalenii_PYR-1 GLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPLGDPIEVQAAG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALGPGREPQRPLLIGSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHL MAB_0939|M.abscessus_ATCC_1997 AAYGIGRETNDPLLIGSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHR MSMEG_0408|M.smegmatis_MC2_155 EVLGAGRAPEEPLLIGSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHL Mvan_1003|M.vanbaalenii_PYR-1 AVLGVGREPDRPLLIGSVKTNIGHLEAASGIAGLLKVILSLEHQVLPKHL Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAH MAB_0939|M.abscessus_ATCC_1997 NFQNPSPHIPWDRLPVEVVREARPWGR---NGRPRIAGVSSFGFAGTNAH MSMEG_0408|M.smegmatis_MC2_155 NFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGVSSFGFAGTNAH Mvan_1003|M.vanbaalenii_PYR-1 NFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGISSFGFSGTNAH Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VILEEAPLAAEPAQES---VDDGRFTLLPLSARTPAALMAVADRYRDWLV MAB_0939|M.abscessus_ATCC_1997 VILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAALAQLADKYRAWLN MSMEG_0408|M.smegmatis_MC2_155 VILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTPEALVRLAGEYRDWLR Mvan_1003|M.vanbaalenii_PYR-1 VLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTPDALAATAHRLRTWLA Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLLGALADDRPAPG MAB_0939|M.abscessus_ATCC_1997 AHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVELLSAVADDRPAPG MSMEG_0408|M.smegmatis_MC2_155 AHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELLGALADDRPAPG Mvan_1003|M.vanbaalenii_PYR-1 ANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELLGALAEDRPGPG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAETLRECAAAVDG MAB_0939|M.abscessus_ATCC_1997 LGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFADTLNRCAAAVAD MSMEG_0408|M.smegmatis_MC2_155 LVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAETVRKCAEAVAD Mvan_1003|M.vanbaalenii_PYR-1 LARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYREVMTRCAEAVAD Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVEMGLARLWQSWG MAB_0939|M.abscessus_ATCC_1997 VLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAVEMGLARLWQSWG MSMEG_0408|M.smegmatis_MC2_155 ILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVELGLARLWQSWG Mvan_1003|M.vanbaalenii_PYR-1 VLERPLLDVVFDAD------GGEALRHTSYAQPALYAVEMGLARLWQSWG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLFGSLPSGGRMAA MAB_0939|M.abscessus_ATCC_1997 FEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAA MSMEG_0408|M.smegmatis_MC2_155 FEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAA Mvan_1003|M.vanbaalenii_PYR-1 IEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLFGSLPEGGRMAA Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VFAAAERVEALTDEYPALSVAAYNGANTVLSGPATDLERAVAGLVADGVR MAB_0939|M.abscessus_ATCC_1997 VFTDAERAERLTDEFPSLSVAAYNGANTVLSGPAQDLEKAIAALVADGVR MSMEG_0408|M.smegmatis_MC2_155 VFTAPERAERLTDEYPSLSVAAYNGANTVLSGPAKDLESAVATLVADGVR Mvan_1003|M.vanbaalenii_PYR-1 VFAPADRVESCTVDSPLLSVAAYNGDNTVLSGPAGDLERAVAGFSAAGVR Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK CDWLETSHAFHSALLDPILDDFESYARGITFTAPQRILIDNRTGAALGRS MAB_0939|M.abscessus_ATCC_1997 CDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQRILIDNRTGTALGRS MSMEG_0408|M.smegmatis_MC2_155 CDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRILIDNRTGSALGRS Mvan_1003|M.vanbaalenii_PYR-1 CDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRTLVCNRSGEVLSRH Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEIGPRPVLTAAALSAW MAB_0939|M.abscessus_ATCC_1997 VKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAW MSMEG_0408|M.smegmatis_MC2_155 TRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEIGPRPVLTATALAAW Mvan_1003|M.vanbaalenii_PYR-1 ARLDGQYWRRHARQPVRFAESVRTLADLGCRLLMEIGPQPVLTAAAMRTW Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PDPATSPRVIASLRRTTADQRQITEAVADAYVLGHLPRFAAFRRDGARVL MAB_0939|M.abscessus_ATCC_1997 PDPATAPRAIASLRRNTADHRQITEAAADAYVLGHLPDFGAFQHAPARKL MSMEG_0408|M.smegmatis_MC2_155 PDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHLPDFRAFRQPDARKL Mvan_1003|M.vanbaalenii_PYR-1 PGTVTAPRVAASMRRKGSDRRQITEALAQAYVAGHRPETAARQHGRGRLL Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DLPTYPFEHRQYWFSDSRE---PVAAAPQR---GARTETVRLLEDGRIEE MAB_0939|M.abscessus_ATCC_1997 DLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEE MSMEG_0408|M.smegmatis_MC2_155 DLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEE Mvan_1003|M.vanbaalenii_PYR-1 DLPTYPFQHRAYWFP--------QGQARTAPTDPVHTETVRFLDEERIDE Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LAALLGGTVDDPFTFDVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPP MAB_0939|M.abscessus_ATCC_1997 LANLLGGVDGDQQTLNVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPL MSMEG_0408|M.smegmatis_MC2_155 LAALIDGETVDEQTLRVLNKLAARHNQQRSTHVDPDARYEIRWDAIASAA Mvan_1003|M.vanbaalenii_PYR-1 LAALLDGPTGSAQTVDVLSKLAARHRQQRGAQSIADARYQIRWEKSEAPG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VGADAADGITWLLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHEL MAB_0939|M.abscessus_ATCC_1997 SGSQAAGGVTWLLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAEL MSMEG_0408|M.smegmatis_MC2_155 ASTGAAA--DWILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADEAQL Mvan_1003|M.vanbaalenii_PYR-1 AARPTTEATTWLLVTHDSRAAQPIAEVLERRGHPYHIVGLPGSDADAAPA Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ADTLRDAAADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFG MAB_0939|M.abscessus_ATCC_1997 VEALRSAADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFR MSMEG_0408|M.smegmatis_MC2_155 VDTLRAASAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFR Mvan_1003|M.vanbaalenii_PYR-1 EEALRATVSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQ Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAVAAQLRSPMWLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWG MAB_0939|M.abscessus_ATCC_1997 AAAAAELRAPIWIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWG MSMEG_0408|M.smegmatis_MC2_155 AANDAELRSPIWLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWG Mvan_1003|M.vanbaalenii_PYR-1 LAATAGARAPIWLITAGAQRITGDETVEPAQTSLWGFGRAAALEQPELWG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDT MAB_0939|M.abscessus_ATCC_1997 GLADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREE MSMEG_0408|M.smegmatis_MC2_155 GLADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPRLVRRTG Mvan_1003|M.vanbaalenii_PYR-1 GLADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVARLTRCAE Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LPSGKPLHLRADATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDE MAB_0939|M.abscessus_ATCC_1997 LPSGKPLEVRSDATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGE MSMEG_0408|M.smegmatis_MC2_155 EPSDTPLPVREDRTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGD Mvan_1003|M.vanbaalenii_PYR-1 KANAAALELRREATYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRSASD Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHA MAB_0939|M.abscessus_ATCC_1997 AARQRIDALAA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHA MSMEG_0408|M.smegmatis_MC2_155 DARRRLDGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHA Mvan_1003|M.vanbaalenii_PYR-1 TVRQRIDAMRERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGIVHA Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSS MAB_0939|M.abscessus_ATCC_1997 AGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSS MSMEG_0408|M.smegmatis_MC2_155 AGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSS Mvan_1003|M.vanbaalenii_PYR-1 AGEIGTSPLRTLDDAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLATSS Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IASVWGGFGQAAYGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQ MAB_0939|M.abscessus_ATCC_1997 IAAVWGGYGQTAYSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAE MSMEG_0408|M.smegmatis_MC2_155 IASVWGGFGQTAYGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAE Mvan_1003|M.vanbaalenii_PYR-1 IASVWGSHGQTAYGAANAFLDGLADSLRARGIPGISVNFGPWAAGMADAK Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SRARLEQRGIKTLSPADALAGLSDAVISAAP---HPVVARVDWSRFLPLY MAB_0939|M.abscessus_ATCC_1997 SRARLEQRGIKTLSPTDALAGLADVVAASGSNAVQGVIARIDWARFLPLY MSMEG_0408|M.smegmatis_MC2_155 SRARLEQRGVRTLSPAEALAGMADVVAGPVQ----GVVAKIDWSRFLPLY Mvan_1003|M.vanbaalenii_PYR-1 AREQLSRRGVKTLAPADALAGMADVIAASTA---HAVVARIDWATFLPVY Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QQAGRRGFLAELERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRL MAB_0939|M.abscessus_ATCC_1997 QQAGKRGFLAELDREVPSHLA--GVAGAQSGSTQLVERLANAPVQQRKKL MSMEG_0408|M.smegmatis_MC2_155 QQAGRRAFLSELESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSL Mvan_1003|M.vanbaalenii_PYR-1 QLQRRRAFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTLAPVEQRRKL Rv2947c|M.tuberculosis_H37Rv -------------------------------MIEEQRTMSVEGADQQSEK Mb2971c|M.bovis_AF2122/97 -------------------------------MIEEQRTMSVEGADQQSEK MLBr_00135|M.leprae_Br4923 ------------------------------------MTASVEGADQKSEK MMAR_1762|M.marinum_M ------------------------------------MTTSGESADQQNDK MUL_2005|M.ulcerans_Agy99 ------------------------------------MTTSGESADQQNDK MAV_3108|M.avium_104 --------------------------------------------MPGTEQ TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LTDYLRDAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKE MAB_0939|M.abscessus_ATCC_1997 LTDYLRDAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKE MSMEG_0408|M.smegmatis_MC2_155 ITNYLRNAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKD Mvan_1003|M.vanbaalenii_PYR-1 VLEYLRAAVAEVTRVDAAEIRDEAGFFDLGMDSLMAIELRRRLEQGLGKE Rv2947c|M.tuberculosis_H37Rv LFHYLKKVAVELDETRARLREYEQ-------------------------- Mb2971c|M.bovis_AF2122/97 LFHYLKKVAVELDETRARLREYEQ-------------------------- MLBr_00135|M.leprae_Br4923 LISYLKKVVVELDETRARLREYEQ-------------------------- MMAR_1762|M.marinum_M LFRYLKKVAVELDEARARLREYEQ-------------------------- MUL_2005|M.ulcerans_Agy99 LFRYLKKVAVELDEARARLREYEQ-------------------------- MAV_3108|M.avium_104 HLDYLKRLTADLRRTRRRVAELEG-------------------------- TH_4621|M.thermoresistible__bu -----VNIVGDTP------------------------------------- . : Mflv_0405|M.gilvum_PYR-GCK IPVTLVMDHPRLSDAADYLLGDVLGLTEAAT-APKAATVVSTAADEPIAI MAB_0939|M.abscessus_ATCC_1997 IPVTLVMDHPRISDVADYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAI MSMEG_0408|M.smegmatis_MC2_155 IPVTLVMDHPRLSDAADYLLVEVLGLGEQTN--VRQASTVTARTDDPIAV Mvan_1003|M.vanbaalenii_PYR-1 LPVTLAMDHPHLSDAAEYVLGDVLGLSEHTV--AQPDTPSTVRTDDPIAI Rv2947c|M.tuberculosis_H37Rv ------------------------------------------RATEPVAV Mb2971c|M.bovis_AF2122/97 ------------------------------------------RATEPVAV MLBr_00135|M.leprae_Br4923 ------------------------------------------RATEPVAV MMAR_1762|M.marinum_M ------------------------------------------RATEPVAV MUL_2005|M.ulcerans_Agy99 ------------------------------------------RATEPVAV MAV_3108|M.avium_104 ------------------------------------------RLSEPVAV TH_4621|M.thermoresistible__bu --------------------------------------------VNAVAV :.:*: Mflv_0405|M.gilvum_PYR-GCK VAVSCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAA MAB_0939|M.abscessus_ATCC_1997 VAVSCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVA MSMEG_0408|M.smegmatis_MC2_155 VAVSCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTP Mvan_1003|M.vanbaalenii_PYR-1 VGMACRFPG-ADDTDAFWSVLAEGADLIREIPDDR-FDINEFYDPDPEAA Rv2947c|M.tuberculosis_H37Rv VGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAE Mb2971c|M.bovis_AF2122/97 VGIGCRFPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAE MLBr_00135|M.leprae_Br4923 VGIGCRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAE MMAR_1762|M.marinum_M VGIGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAE MUL_2005|M.ulcerans_Agy99 VGIGCRFPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAE MAV_3108|M.avium_104 VGMACRYAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAK TH_4621|M.thermoresistible__bu IGMACRLPGGIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVP :.:.** .* ..: :*. : * : :.* ** :* : :**:* . Mflv_0405|M.gilvum_PYR-GCK GKTYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERA MAB_0939|M.abscessus_ATCC_1997 GKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERA MSMEG_0408|M.smegmatis_MC2_155 GKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERA Mvan_1003|M.vanbaalenii_PYR-1 GKIYSRYGGFLDGVDGFDPEFFGISPREAVWIDPQQRLVLETAWEGLERA Rv2947c|M.tuberculosis_H37Rv GKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHA Mb2971c|M.bovis_AF2122/97 GKTYTRWGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHA MLBr_00135|M.leprae_Br4923 GKTYTRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYA MMAR_1762|M.marinum_M GKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHA MUL_2005|M.ulcerans_Agy99 GKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHA MAV_3108|M.avium_104 GKMYTRQGSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERA TH_4621|M.thermoresistible__bu GRTVSRWGAFLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHA *: :* *.*:: **. ***: *.: ::****::** **.:* * Mflv_0405|M.gilvum_PYR-GCK GYAPSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISG MAB_0939|M.abscessus_ATCC_1997 GYSPAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISG MSMEG_0408|M.smegmatis_MC2_155 GYAPSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISG Mvan_1003|M.vanbaalenii_PYR-1 GYSAAALRGSRSGVYVGVGANEYSHLLSGGSLDGIEAQFITGNALNVIAG Rv2947c|M.tuberculosis_H37Rv GIDPLSLRGSATGVYTGIFAASYGNRDTG----GLQGYGLTGTSISVASG Mb2971c|M.bovis_AF2122/97 GIDPLSLRGSATGVYTGIFAASYGNRDTG----GLQGYGLTGTSISVASG MLBr_00135|M.leprae_Br4923 GIDPLSLRGSATGVFTGIFAPSYGSRDTG----GLQGYGLTGTAVSVASG MMAR_1762|M.marinum_M GIDPMSLRGSSTGVFTGIFAPSYGGKDVG----ALQGYGLTGSPVSVASG MUL_2005|M.ulcerans_Agy99 GIDPMSLRGSSTGVFTGIFAPSYGGKDVG----ALQGYGLTGSPVSVASG MAV_3108|M.avium_104 GIDPSALRGTATGVFAGVIHAGYGGEVKG----ELEGYGLTGSTLSVTSG TH_4621|M.thermoresistible__bu GLTPADVEGSSTGVFVGLSHDDYALLTSDAG-ALEEAYGFTGSAFSMASG * . :.*: :*::.*: *. : :**.... :* Mflv_0405|M.gilvum_PYR-GCK RVAFALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLL MAB_0939|M.abscessus_ATCC_1997 RVAFALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLL MSMEG_0408|M.smegmatis_MC2_155 RVAFALGFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLL Mvan_1003|M.vanbaalenii_PYR-1 RVSFTLGLEGPAVAVDTACSSSLVAVHQACQGLQSGDCDLALAGGVNVLL Rv2947c|M.tuberculosis_H37Rv RVSYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMG Mb2971c|M.bovis_AF2122/97 RVSYVLGLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMG MLBr_00135|M.leprae_Br4923 RVSYVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMG MMAR_1762|M.marinum_M RVAYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMG MUL_2005|M.ulcerans_Agy99 RVAYVLGLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMG MAV_3108|M.avium_104 RVSYVLGLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMA TH_4621|M.thermoresistible__bu RIAYRLGVHGPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVML *::: **..***::*******:*:*:* * .*: *:.*:*****. *: Mflv_0405|M.gilvum_PYR-GCK SPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRD MAB_0939|M.abscessus_ATCC_1997 SPVTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERD MSMEG_0408|M.smegmatis_MC2_155 SPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRD Mvan_1003|M.vanbaalenii_PYR-1 SPATTIATSRARMLSPDGRCKTFDAAADGYVRGEGCGILVLKRLSDAVRD Rv2947c|M.tuberculosis_H37Rv LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRL Mb2971c|M.bovis_AF2122/97 LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRL MLBr_00135|M.leprae_Br4923 LPSIFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRL MMAR_1762|M.marinum_M LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRN MUL_2005|M.ulcerans_Agy99 LPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRN MAV_3108|M.avium_104 TPAAFVEFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRL TH_4621|M.thermoresistible__bu EPRKYTSASGLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRD * * *:. ***:.: :*** .**. :::*:**.** * Mflv_0405|M.gilvum_PYR-GCK GDRVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDY MAB_0939|M.abscessus_ATCC_1997 GDRVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDY MSMEG_0408|M.smegmatis_MC2_155 GDRVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDY Mvan_1003|M.vanbaalenii_PYR-1 GDRIQAVIRGSAVNQDGASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDY Rv2947c|M.tuberculosis_H37Rv GHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQVALANAGLSAADVDV Mb2971c|M.bovis_AF2122/97 GHSVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDV MLBr_00135|M.leprae_Br4923 GHTVLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDV MMAR_1762|M.marinum_M GHNVLAVVRGSAINQDGASNGLTAPNGLAQQRVIQAALANCGLTSADVDV MUL_2005|M.ulcerans_Agy99 GHNVLAVVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDV MAV_3108|M.avium_104 GHPVWAVLRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDV TH_4621|M.thermoresistible__bu NDRILAVVRGTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGM .. : **: .:: **** : .::.*. :* : .*: .*: :. Mflv_0405|M.gilvum_PYR-GCK LEAHGTGTPLGDPIEVQAAAAAYAGARDADRPLLMGSVKTNIGHTESASG MAB_0939|M.abscessus_ATCC_1997 LEAHGTGTPLGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASG MSMEG_0408|M.smegmatis_MC2_155 LEAHGTGTPLGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASG Mvan_1003|M.vanbaalenii_PYR-1 LEAHGTGTSLGDPIEVQAAGAVLGAGRDPDRPLLMGSVKTNVGHLESASG Rv2947c|M.tuberculosis_H37Rv VEAHGTATTLGDPIEAQALLSTYGQGGPAEQPLWVGSIKSNMGHTQAAAG Mb2971c|M.bovis_AF2122/97 VEAHGTATTLGDPIEAQALLSTYGQGRPAEQPLWVGSIKSNMGHTQAAAG MLBr_00135|M.leprae_Br4923 VEAHGTATTLGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAG MMAR_1762|M.marinum_M VEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAG MUL_2005|M.ulcerans_Agy99 VEAHGTATTLGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAG MAV_3108|M.avium_104 VEGHGTGTVLGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAG TH_4621|M.thermoresistible__bu VEAHGTGTPVGDPIEYNSLTQVYGKTG----PCALTSVKTNFGHAESAAG :*.***.* :***** :: . . * : *:*:*.** .:*:* Mflv_0405|M.gilvum_PYR-GCK AAGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQP-NG MAB_0939|M.abscessus_ATCC_1997 AAGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQA-NG MSMEG_0408|M.smegmatis_MC2_155 AAGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQT-NG Mvan_1003|M.vanbaalenii_PYR-1 VAGLIKVVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWRA-DG Rv2947c|M.tuberculosis_H37Rv VAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSV-DG Mb2971c|M.bovis_AF2122/97 VAGVIKMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSV-DG MLBr_00135|M.leprae_Br4923 VAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSV-EG MMAR_1762|M.marinum_M VAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPD-AG MUL_2005|M.ulcerans_Agy99 VAGVIKMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPD-AG MAV_3108|M.avium_104 VAGVIKMVQALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPE-HG TH_4621|M.thermoresistible__bu ALGMMKAILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREG . *::* : :::: :* :*. . .: : : . * * Mflv_0405|M.gilvum_PYR-GCK RPRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPA MAB_0939|M.abscessus_ATCC_1997 RPRRAGVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQ MSMEG_0408|M.smegmatis_MC2_155 RVRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGT Mvan_1003|M.vanbaalenii_PYR-1 RPRRAGVSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATA Rv2947c|M.tuberculosis_H37Rv RPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVE-------ASESTGG- Mb2971c|M.bovis_AF2122/97 RPRRAAVSSFGISGTNAHLILEEAPVPAPAEAPVE-------ASESTGGP MLBr_00135|M.leprae_Br4923 RPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTA-------DQQRLSVV MMAR_1762|M.marinum_M RPRRAGVSSFGISGTNAHVILEEAPAPEAVPDSES-------NKGEPSLP MUL_2005|M.ulcerans_Agy99 RPRRAGVSSFGISGTNAHVILEEAPAPEAVPDSES-------NKGEPSLP MAV_3108|M.avium_104 GPRRAGVSSFGISGTNAHVIVEQAPAAAETEAAPA-------SSTMPDAV TH_4621|M.thermoresistible__bu CPRRAAVSSYGMSGTNVHAVLEQAPEPVQRPEESA------------DTD ***.***:*::***.* ::*:.* Mflv_0405|M.gilvum_PYR-GCK PAPVEVLPLSARSPEALVALAQRYETWLTAH-PEADLADVCRTAGTGRSH MAB_0939|M.abscessus_ATCC_1997 SAPVSVLPLSARSPEALAAVAQRYESWLAAH-PDVDLEDVCLTAGRGRSH MSMEG_0408|M.smegmatis_MC2_155 DDSPQVLALSARSPEALVELARRYDDWLSAT-PGLDIADVCHTAGVGRSH Mvan_1003|M.vanbaalenii_PYR-1 PEPAGVLPISARSPEALTALARRYESWLTAH-PDADIADVCYTAGAGRSH Rv2947c|M.tuberculosis_H37Rv --------------------RGRRWCRG---------------------- Mb2971c|M.bovis_AF2122/97 RPSMVPWVISARSAEALTAQAGRLMAHVQAN-PGLDPIDVGCSLAS-RSV MLBr_00135|M.leprae_Br4923 P-----WVVSGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSV MMAR_1762|M.marinum_M VVP---WVISARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSA MUL_2005|M.ulcerans_Agy99 VVP---WVISARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSA MAV_3108|M.avium_104 VP----WVVSARSAEALAGQARRLLDHVTAD-AQASPLDVGWSLVSTRAV TH_4621|M.thermoresistible__bu AAGPLVFALSSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAH * Mflv_0405|M.gilvum_PYR-GCK FEHRAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQG MAB_0939|M.abscessus_ATCC_1997 FEHRAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNHPTTAWLFTGQG MSMEG_0408|M.smegmatis_MC2_155 FEYRAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHRPTTAWLFTGQG Mvan_1003|M.vanbaalenii_PYR-1 FEHRAALVVDSVDGARDLLAGLAEDRLGPGAVRGVCGDPPKTAWLFTGQG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 FEHRAVVVGASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQG MLBr_00135|M.leprae_Br4923 FEHRAVVVGESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQG MMAR_1762|M.marinum_M FEHRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQG MUL_2005|M.ulcerans_Agy99 FEHRAVVVGADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQG MAV_3108|M.avium_104 FEHRAVVVGRERGALATGLAGLASGRPGPATVVGRARSTGKTVLVFPGQG TH_4621|M.thermoresistible__bu RPVRTTVIADGVEALTAGLREVADGDAPYQPAVG--MDDKAPVWVFSGQG Mflv_0405|M.gilvum_PYR-GCK SQYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVP MAB_0939|M.abscessus_ATCC_1997 SQYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGK MSMEG_0408|M.smegmatis_MC2_155 SQYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET--- Mvan_1003|M.vanbaalenii_PYR-1 SQYPGMARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN--- Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 AQRIGMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADL--- MLBr_00135|M.leprae_Br4923 AQRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADAGL--- MMAR_1762|M.marinum_M SQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLREVMWGSDAAL--- MUL_2005|M.ulcerans_Agy99 SQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSDVAL--- MAV_3108|M.avium_104 SQTLGMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGADPEL--- TH_4621|M.thermoresistible__bu SQWAGMGAELLATEQVFAAKIAEIEPLVARESGFSVTEAMTASETVTG-- Mflv_0405|M.gilvum_PYR-GCK PTETLRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVA MAB_0939|M.abscessus_ATCC_1997 AGEALRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA MSMEG_0408|M.smegmatis_MC2_155 -ADLLQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVA Mvan_1003|M.vanbaalenii_PYR-1 -GQTLRHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVA Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 ----LDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAA MLBr_00135|M.leprae_Br4923 ----LDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVA MMAR_1762|M.marinum_M ----LDSTEFAQPALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVA MUL_2005|M.ulcerans_Agy99 ----LDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVA MAV_3108|M.avium_104 ----LQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVA TH_4621|M.thermoresistible__bu -------IDRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVA Mflv_0405|M.gilvum_PYR-GCK GVFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPR--V MAB_0939|M.abscessus_ATCC_1997 GVFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPR--V MSMEG_0408|M.smegmatis_MC2_155 GVFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPR--V Mvan_1003|M.vanbaalenii_PYR-1 GVFGLEDGARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFADEFPQ--V Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 GVLTLADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEG----V MLBr_00135|M.leprae_Br4923 GVLAPADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG----V MMAR_1762|M.marinum_M GVLTLADAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG----V MUL_2005|M.ulcerans_Agy99 GVLTLVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG----V MAV_3108|M.avium_104 GVLSLRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGG----V TH_4621|M.thermoresistible__bu GALSLEDGVKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDV Mflv_0405|M.gilvum_PYR-GCK SVGAYNGPN-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDP MAB_0939|M.abscessus_ATCC_1997 SVGAYNGPN-TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDP MSMEG_0408|M.smegmatis_MC2_155 SVGAYNGPN-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDP Mvan_1003|M.vanbaalenii_PYR-1 SVAAYNGPN-TVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDP Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 GIAAINAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEP MLBr_00135|M.leprae_Br4923 GIAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEP MMAR_1762|M.marinum_M GIAAINAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEP MUL_2005|M.ulcerans_Agy99 GIAAINAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEP MAV_3108|M.avium_104 SIAAVNGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEP TH_4621|M.thermoresistible__bu VLSVIASPESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDP Mflv_0405|M.gilvum_PYR-GCK VLDEFESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPV MAB_0939|M.abscessus_ATCC_1997 ILDEFESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPV MSMEG_0408|M.smegmatis_MC2_155 VLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPV Mvan_1003|M.vanbaalenii_PYR-1 VLDEFESCAARLAYAAPTRPLVCNRTGAVVTGPG-VIDAQYWRRHARQPV Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 MLEEFARVAARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPV MLBr_00135|M.leprae_Br4923 MLEEFVRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAV MMAR_1762|M.marinum_M MLEEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAV MUL_2005|M.ulcerans_Agy99 MLEEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAV MAV_3108|M.avium_104 MLDGFAAAAAGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPV TH_4621|M.thermoresistible__bu ILDELEEILADLQPMTPTVPYYSATS--YDPREKPVCDADYWVDNLRHEV Mflv_0405|M.gilvum_PYR-GCK QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIASLRKG MAB_0939|M.abscessus_ATCC_1997 QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPRAIVSLRKG MSMEG_0408|M.smegmatis_MC2_155 QFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPRAVASLRKG Mvan_1003|M.vanbaalenii_PYR-1 QFAESVRTLADLGCSVLMEIGPQPFLIAAALRVWPESAATPRAIPSLRKG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 RFADSARHLQTLGATHFIEAGPGSGLTGSIEQSLAP--AEAMVVSMLGKD MLBr_00135|M.leprae_Br4923 RFVDSARHLQTLGATHFIESGPSSGLMGAIEQSLAP--AEAVVVSMMGKD MMAR_1762|M.marinum_M RFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAP--AEAVVVSMLGKD MUL_2005|M.ulcerans_Agy99 RFADSARQLHTLGVTHFVEVGPGSGLTGSIEQSLAP--AEAVVVSMLGKD MAV_3108|M.avium_104 RFVDGVRLAESQGAGVFLEVGPGAALTSAVEQSLTS--DRAMSVVTMPKG TH_4621|M.thermoresistible__bu RFAAAVQAALEDGFRVFGELSPHPLLTRAVEQTARGLDMPVAALPAMRRE Mflv_0405|M.gilvum_PYR-GCK VADRRQIADALAAAYIGGHKPDFAALHEQRG-VRLELPTYPFQRRRFWPK MAB_0939|M.abscessus_ATCC_1997 VEDRRQIADALASAYVSGHRPNFAALQRHPR-RTVELPTYPFQRRRFWPK MSMEG_0408|M.smegmatis_MC2_155 VADRRQIADALASAYVGGHRPDFAAVHRQPR-RPVELPTYPFQRRRFWPK Mvan_1003|M.vanbaalenii_PYR-1 PDARRQLAEAVAAAYIAGHRLDFTGHDGGPH-RRLPLPTYPFQHRSYWPK Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 RPELASALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWET MLBr_00135|M.leprae_Br4923 RPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWET MMAR_1762|M.marinum_M RPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEV MUL_2005|M.ulcerans_Agy99 RPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEV MAV_3108|M.avium_104 RPEVDSLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLS TH_4621|M.thermoresistible__bu QEMPHGVRTMVGDLFAAGAAVDFAALYPSGRLVDAPLPTWTRRKLVLSRE Mflv_0405|M.gilvum_PYR-GCK S---AGMAIDGRVGASAGSGILGSGKD-LASGD-SVYTSRLSVKTQPWLS MAB_0939|M.abscessus_ATCC_1997 S---SGTAIEG--GGGLPSGILGRGED-LASGD-SVYISRLSVRSQPWLS MSMEG_0408|M.smegmatis_MC2_155 A---SSIAVDG---GTAASGILGSGKD-LASGD-TIYTSRLSVKSQPWLA Mvan_1003|M.vanbaalenii_PYR-1 T---AGIRSDG----SSGSGLLGSAQD-LASGD-IVHTSRLSVKTQPWLS Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 PGADGPADAAGLGLGATEHALLGAVVERPDSDE-VVLTGRLSLADQPWLA MLBr_00135|M.leprae_Br4923 PGTDGTASVSGLGLGSTEHALLGAVVERPDSGG-VVLTGRLSLANQPWLA MMAR_1762|M.marinum_M PGADGPADATGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALADQPWLA MUL_2005|M.ulcerans_Agy99 PGADGPADATGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALADQPWLA MAV_3108|M.avium_104 GDAVGSANIASLGLAEAEHPLLGAVLDRPDSGG-VVLTGRLSTAAQPWLA TH_4621|M.thermoresistible__bu N----GEQQTRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLA Mflv_0405|M.gilvum_PYR-GCK DHVIYGTVVVPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKSSREV MAB_0939|M.abscessus_ATCC_1997 DHVIYGTVVVPGATYAAMALAAVGTP--ARAKDVFFYEPIILPEKSSREV MSMEG_0408|M.smegmatis_MC2_155 DHVIYGTVVVPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKASREV Mvan_1003|M.vanbaalenii_PYR-1 DHVIYGTVVVPGATYAAMALAAMPTP--ARVQEVFFYEPIILGDKDSREV Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 DHVVNGVVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQV MLBr_00135|M.leprae_Br4923 DHVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQV MMAR_1762|M.marinum_M DHVIGGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQV MUL_2005|M.ulcerans_Agy99 DHVIGGVVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQV MAV_3108|M.avium_104 DHAVAGTVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQL TH_4621|M.thermoresistible__bu DHQIHTVAALPGAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTE Mflv_0405|M.gilvum_PYR-GCK QLTVHPSVDGE-SKFQVHSRPYGERGAEWALNAEGVVASGVGD---SPAA MAB_0939|M.abscessus_ATCC_1997 QLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDDAEPAPE MSMEG_0408|M.smegmatis_MC2_155 QLTLHPADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSD---PDAA Mvan_1003|M.vanbaalenii_PYR-1 QLMLHRTDDADGWTFEVHSRPYGDRDADWSRNASGTVAAGVGD-----AA Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 QVVVG-AADESGHRAVSVYSRGDQSQG-WLLNAEGMLG---------VAA MLBr_00135|M.leprae_Br4923 QVVVA-AADESSRRAVSVYSRGDQSHGGWLLNAEGLLE---------VDA MMAR_1762|M.marinum_M QVIVG-AADDSGNRALSVYSRGDQSED-WLLNAEGMLG---------VEA MUL_2005|M.ulcerans_Agy99 QVIVG-TADDSGNRALSVYSRGDKSED-WLLNAEGMLG---------VEA MAV_3108|M.avium_104 QVVVADAAGQPGSRSVAVYSR--VAQSEWTLHAEGVLS---------EAA TH_4621|M.thermoresistible__bu VSAVASAVEPGTLEFAVETAKDGEHERRATAVLGAADD----------TE Mflv_0405|M.gilvum_PYR-GCK AGDLEDPVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLKSLWLG-- MAB_0939|M.abscessus_ATCC_1997 AAEPAEPVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLKSLWLG-- MSMEG_0408|M.smegmatis_MC2_155 ADEQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLG-- Mvan_1003|M.vanbaalenii_PYR-1 PDAAADPVDNAIERLTRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVG-- Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 AETPMDLSVWPPEGAESVDISDGYAQLAERGYAYGPAFQG-LVAIWRR-- MLBr_00135|M.leprae_Br4923 AEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQG-LVAIWRR-- MMAR_1762|M.marinum_M ASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRR-- MUL_2005|M.ulcerans_Agy99 ASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRR-- MAV_3108|M.avium_104 PAPAAELSVWPPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRAVWRR-- TH_4621|M.thermoresistible__bu PPQAHDIDALLAEHPTRIEGDELRQWFDQRGVQFGPAFTGLTAARIPEGT Mflv_0405|M.gilvum_PYR-GCK EGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVN MAB_0939|M.abscessus_ATCC_1997 EGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVN MSMEG_0408|M.smegmatis_MC2_155 DGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVN Mvan_1003|M.vanbaalenii_PYR-1 TGEAVGDIAVGAELGEHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADP Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 GSELFAEVVAPGEAGVAVDRMGMHPAVLDAVL----HALGLAVEKTQAST MLBr_00135|M.leprae_Br4923 GSELFAEVVAP--TGVVVDGMGMHPALLDAVL----HALGLAIENTQATT MMAR_1762|M.marinum_M DSELFAEVVAP--SGVAVDKMGMHPVVLDAVL----HALGLTAEQNPDSD MUL_2005|M.ulcerans_Agy99 DSELFAEVVAP--SGVAVDKMGMHPVVLDAVL----HALGLTAEQNPDSD MAV_3108|M.avium_104 GAETFAEVELPEQAGVSTGRFGIHPVLLDAAL----HALGVADKR----L TH_4621|M.thermoresistible__bu VTSVLAEVGLPGQIRSQQAPYGIHPALLDACF----QSVAAHPDVQGAGS Mflv_0405|M.gilvum_PYR-GCK DLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRH MAB_0939|M.abscessus_ATCC_1997 DLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRH MSMEG_0408|M.smegmatis_MC2_155 DLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRA Mvan_1003|M.vanbaalenii_PYR-1 ELFLPLRYGRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRN Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 ETRLPFCWRGVSLHAGGAGRVRARF------ASAGADAISVDVCDATGLP MLBr_00135|M.leprae_Br4923 EMRLPFCWRGVSLHAGGAGRVRARF------TSAGADAIAVDIADSAGLP MMAR_1762|M.marinum_M ETKLPFCWRGVSLHAGGAGRVRARL------TMSGPDSISVEIADAAGLP MUL_2005|M.ulcerans_Agy99 ETKLPFCWRGVSLHAGGAGRVRARL------TMSGPDSISVEIADAAGLP MAV_3108|M.avium_104 ETVLPFSWQGVSLHAAGASRVRVRL------APAGAGAVSVELADASGVP TH_4621|M.thermoresistible__bu GLLLPLGVRRLQAFGPTRGARYCYAR--VTDADGSKAEADLDVLDEHGNV Mflv_0405|M.gilvum_PYR-GCK LGGVREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVPVP----ES MAB_0939|M.abscessus_ATCC_1997 LGGIREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVAVPPVAGEG MSMEG_0408|M.smegmatis_MC2_155 LGGIREFTVKRAPREALLRGLGGDAT----RLLYTLGWHEVPPP------ Mvan_1003|M.vanbaalenii_PYR-1 LGGIREFTVKRAPREALLRGLGADAT----RLIYRVGWRETSPP---VRD Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 VLTVRSLVTRPITAEQLRAAVTAAGG-ASDQGPLEVVWSPISVV------ MLBr_00135|M.leprae_Br4923 VLTVRSLVTRAMTAEQLRTAVTAAGG-ALEQGPMDLVWSPIPLS------ MMAR_1762|M.marinum_M VLTVGALVTRAMSAAQLRAAVAAAGGGAPDQGPLDVIWSPIPLS------ MUL_2005|M.ulcerans_Agy99 VLTVGALVTRAMSAAQLRAAVAEAGGGAPDQGPLDVIWSPIPLS------ MAV_3108|M.avium_104 VLSVRELVTRAVSAEQLAAAVAVRSG---SGELLDVAWSVIEPR------ TH_4621|M.thermoresistible__bu LLRVQGLLMGGAAADGDDRDRVLGER------LLTIEWQRRDLP------ Mflv_0405|M.gilvum_PYR-GCK GDGAAPQGTWLIGGFDELAVSVPGCIPADR----------------TNPE MAB_0939|M.abscessus_ATCC_1997 EESAASIGTWLIAGFDELAAKVPGCIPLNRE---------------TDPE MSMEG_0408|M.smegmatis_MC2_155 PSADDAVGTWLIAGFDELAAKVPGCVPIDRN---------------TDLQ Mvan_1003|M.vanbaalenii_PYR-1 DGALGPSSTWLVAGLDALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDE Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 SGGANGSAPPAPVSWADFCAGSDG-------------------------- MLBr_00135|M.leprae_Br4923 SDGHGG-GLPSVVSWADYCAGRGN-------------------------- MMAR_1762|M.marinum_M GSGTNGSAQPAVVSWADFCAGGDGGA------------------------ MUL_2005|M.ulcerans_Agy99 GSGTNGSAQPAVVSWADFCAGGDGGA------------------------ MAV_3108|M.avium_104 NSLPDNPISEGVTVWEPAAVDGAG-------------------------- TH_4621|M.thermoresistible__bu -EADSAAGKWLLVSTSATADVSATRLSDALKQAG----------AESTSM Mflv_0405|M.gilvum_PYR-GCK SLRQLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLG MAB_0939|M.abscessus_ATCC_1997 LLGEVLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLS MSMEG_0408|M.smegmatis_MC2_155 VLGEVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLS Mvan_1003|M.vanbaalenii_PYR-1 HWRRLFALADERRAPVAGVVLGVTGRARPEE-PSADFAARLEAQIRDVLG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 ---------------DASVVVWELESAGGQASS---VVGSVYAATHTALE MLBr_00135|M.leprae_Br4923 ---------------DTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQ MMAR_1762|M.marinum_M -------------AGDAGVVVWEPNPAG------EDVVGSVYAATHAALE MUL_2005|M.ulcerans_Agy99 -------------AGDAGVVVWEPNPAG------EDVVGPVYAATHAALE MAV_3108|M.avium_104 -------------------------------------PAAVHAATHQALG TH_4621|M.thermoresistible__bu CWPQQADHADNVDRFRAGIADGVTGVVVLTGPKNGNPDDAAARRGSDYVR Mflv_0405|M.gilvum_PYR-GCK AVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAI MAB_0939|M.abscessus_ATCC_1997 AVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTI MSMEG_0408|M.smegmatis_MC2_155 AVHAAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTI Mvan_1003|M.vanbaalenii_PYR-1 AVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLI Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 VLQSWL-----GADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQ MLBr_00135|M.leprae_Br4923 VLQFWF-----GQDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQ MMAR_1762|M.marinum_M VLQSWF-----DGDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQ MUL_2005|M.ulcerans_Agy99 VLQSWF-----DGDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQ MAV_3108|M.avium_104 VLQSRL-----AGEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQ TH_4621|M.thermoresistible__bu HLVRITRELAEIDGDAPRLFVVTRGAQAVLPQDRPNLEQAGLRGLLRVIG Mflv_0405|M.gilvum_PYR-GCK NEEPALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLL MAB_0939|M.abscessus_ATCC_1997 NEEPALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLL MSMEG_0408|M.smegmatis_MC2_155 NEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLL Mvan_1003|M.vanbaalenii_PYR-1 AEEPGLRCLLVDLDGSEDAGPALARLLGAP-GDEPELALRQGRLLVPRLL Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 AENP-GRIVLIDTDAAVDASVLAG-------VGEPQLLVRGGTVHAPRLS MLBr_00135|M.leprae_Br4923 SEHS-GKIVLIDTDSAVDVAVLAD-------LGESQLLVRCNTVHAARLS MMAR_1762|M.marinum_M AENP-GRIVLVDADAAVEAAELVA-------VGEPQLVVRSGAAHAARLA MUL_2005|M.ulcerans_Agy99 AENP-GRIVLVDADAAVEAAELVA-------VGEPQLVVRSGAAHAARLA MAV_3108|M.avium_104 AEHP-GRVVLVDTDGSLDLATVIG-------CGEPQLVVRDGVAYRARLR TH_4621|M.thermoresistible__bu AEHPHLRTTQIDIADDADLDRVAVQLLGGG--AEDETAWRDGQWYTARLS Mflv_0405|M.gilvum_PYR-GCK PWSRS----GHLTVPRG-GDYVLAPTERGAIDNLRLTDSEVPPPAE--GY MAB_0939|M.abscessus_ATCC_1997 PWSRT----GHLTVPRG-SDYVLAPTERGAIDNLRITEKEVPAPDE--GY MSMEG_0408|M.smegmatis_MC2_155 PWARS----GHLTLPRG-GDFVLAPTERGAIDNLRLTETDVPEPDE--GY Mvan_1003|M.vanbaalenii_PYR-1 PWSRS----GQLAIPRG-TDYVLAPTERGVLDNLRVSETEVTAPPE--GH Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 PAP------ALLALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQ MLBr_00135|M.leprae_Br4923 PAP------QLLALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGH MMAR_1762|M.marinum_M PAA------PLLAVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQ MUL_2005|M.ulcerans_Agy99 PAA------PLLAVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQ MAV_3108|M.avium_104 PAGRR----ALLELPGPPAVWRLAAGDAGTLEDLAVQEHP--AAELAPGQ TH_4621|M.thermoresistible__bu LSPLRPEERKQAVVDCERDGMRLEIRTPGDLETMELAAFDRVPPGP--GQ Mflv_0405|M.gilvum_PYR-GCK VQVRVEAAGLNFRDVLNVLG---LYPGDPGPIGGDFAGTVTQLGEGVTGL MAB_0939|M.abscessus_ATCC_1997 VQVRVEAAGLNFRDVLNVLG---LYPGDPGPIGGDFAGIVTQLGEGVTGV MSMEG_0408|M.smegmatis_MC2_155 VQVRVEAAGLNFRDVLNVLG---LYPGDPGPIGGDFAGTVTQLGAGVSGL Mvan_1003|M.vanbaalenii_PYR-1 VQVRVEAAGLNFRDVLNALG---LYPGDPGPIGGELAGVVTAPGPDVDGF Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 VRVAVAAVGVNFRDVVAALG---MYPGQAPPLGAEGAGVVLETGPEVTDL MLBr_00135|M.leprae_Br4923 MRVAVAAVGVNFRDVVAALG---MYPGQAPPLGAEGAGVVIEIGPEVTGV MMAR_1762|M.marinum_M VRVAVRAVGVNFRDVVAALG---MYPGEAPPLGAEGAGVVLEVGPQVSGV MUL_2005|M.ulcerans_Agy99 VRVAVRAVGVNFRDVVAALG---MYPGAAPPLGAEGAGVVLEVGPQVSGV MAV_3108|M.avium_104 VRVRVAAAGVNFRDVLVALG---MYPG-AAQLGAEGAGVVTEVGAGVTDV TH_4621|M.thermoresistible__bu IEVAVTASSINFADVLIAFGRYPTFDGRRPQLGTDFAGVVTAVGPDVTSH Mflv_0405|M.gilvum_PYR-GCK DVGQRVYGS-MQGAFASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRL MAB_0939|M.abscessus_ATCC_1997 EVGQRVYGS-MQGAFGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVRL MSMEG_0408|M.smegmatis_MC2_155 EIGQRVYGS-MQGAFASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRL Mvan_1003|M.vanbaalenii_PYR-1 DVGQRVFGF-AVGAFASRVNVPVQFLAPVPEGISAVAAATTPAAVLTAGL Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 AVGDAVMG--FLGGAGPLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWY MLBr_00135|M.leprae_Br4923 AVGDAVMG--FLGGAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALF MMAR_1762|M.marinum_M AVGDSVMG--FLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALF MUL_2005|M.ulcerans_Agy99 AVGDSVMG--FLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALF MAV_3108|M.avium_104 AVGDAVMG--IFGLVGSEAAVDRRLVTRVPPGWSMAQAAGIPVVFLTAYY TH_4621|M.thermoresistible__bu RVGDRVGGLSPNGCWSTFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWY Mflv_0405|M.gilvum_PYR-GCK SFD-WAQVKSGDKVLIHAASGGVGLAAVQMAQQCGAEVYATAST-FKRAT MAB_0939|M.abscessus_ATCC_1997 SFD-WAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEVFATAST-FKRAT MSMEG_0408|M.smegmatis_MC2_155 AFD-WAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEVFATAST-FKRST Mvan_1003|M.vanbaalenii_PYR-1 AFD-WAALRAGDRVLIHAASGGVGLAAVQLARQRGATVFATASG-YKRPM Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 GLADLAEIKAGESVLIHAGTGGVGMAAVQLARQWGVEVFVTASR-GKWDT MLBr_00135|M.leprae_Br4923 GLADLAGIRAGESVLIHAGTGGVGMAAVQFARHWGVEIFVTASR-GKWDT MMAR_1762|M.marinum_M GLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASR-GKWDT MUL_2005|M.ulcerans_Agy99 GLQDLAKIQPGESVLIHAGTGGVGMAAVQLARHWGVEIFVTASR-GKWDT MAV_3108|M.avium_104 GLSVLAGLRAGQRVLVHAATGGVGMAAVQLARHWGAEVFATASR-GKWDT TH_4621|M.thermoresistible__bu GLHDLARLGAGEKVLIHSATGGVGLAAIAIARSVGAQIYATAGSPARRDL Mflv_0405|M.gilvum_PYR-GCK LRKLGVK--HVYDSRTTDFAEQILADTDGAGVDVVLNSLTSEGFIEATLR MAB_0939|M.abscessus_ATCC_1997 LRKLGVK--YVYDSRTTDFADQILADTDGAGVDVVLNSLTSEGFIEATLR MSMEG_0408|M.smegmatis_MC2_155 LRRLGVK--YVYDSRTTDFADQILADTNGAGVDVVLNSLTSAGFVEATLK Mvan_1003|M.vanbaalenii_PYR-1 LRAMGVD--HVYDSRTTDFADQILADTDGAGVDVVLNSLTNDGFVAATVR Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 LRAMGFDDDHIGDSRTCEFEEKFLAVTEGRGVDVVLDSLAGE-FVDASLR MLBr_00135|M.leprae_Br4923 LRDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLR MMAR_1762|M.marinum_M LRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLR MUL_2005|M.ulcerans_Agy99 LRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLR MAV_3108|M.avium_104 LRAMGFDDAHIADSRTLDFEQKFGAAPG--GMDVVLNSLAGE-FNDASLR TH_4621|M.thermoresistible__bu LRDMGIE--HVYDSRSTAFADEIRRDTDGYGVDVVLNSLPGAAQRAG-LE Mflv_0405|M.gilvum_PYR-GCK ATAQHGRFAEIAKRDIWTVEQMAAA--RPDLAYEIVALDTVMFTEPDRIR MAB_0939|M.abscessus_ATCC_1997 ATAKNGRFAEIAKRDIWTTEQMAQS--RPDIAYEIVALDTVMFQEPDRIR MSMEG_0408|M.smegmatis_MC2_155 ATAQGGRFAEIAKRDIWSHEQMAEA--RPDIAYEIVALDTVMFTEPDRIR Mvan_1003|M.vanbaalenii_PYR-1 ATARNGRFAEIAKRDIWSPEQMAAA--RPDIDYEVLALDAVMQQDPDRIQ Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 LLVRGGRFLEMGKTDIRDAQEIAAN--YPGVQYRAFDLSEAG---PARMQ MLBr_00135|M.leprae_Br4923 LLVRGGRFLEMGKTDIRDAQEIAAN--YPGVQYRAFDLSEAG---PVRMQ MMAR_1762|M.marinum_M LLVRGGRFLEMGKTDIRDADKIAAN--YPGVWYRAFDLSEAG---PVRMQ MUL_2005|M.ulcerans_Agy99 LLVRGGRFLEMGKTDIRDADKIAAN--YPGVWYRAFDLSEAG---PVRMQ MAV_3108|M.avium_104 LLGPGGRFIEMGKTDLRDPDVVARA--HPGVRYRAFDLMEAG---PDRIA TH_4621|M.thermoresistible__bu LLSFGGRFIEIGKRDIYGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIR Mflv_0405|M.gilvum_PYR-GCK DLLTEVSAGLRDGAWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPN MAB_0939|M.abscessus_ATCC_1997 VLLTEVSEGLAKGEWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPN MSMEG_0408|M.smegmatis_MC2_155 DLLTEVSDGMARGEWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQVPK Mvan_1003|M.vanbaalenii_PYR-1 LLLADLADSLARGETAPLPFEAYPLAEATTAFRRMQQARHTGKIILQMPK Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 EMLAEVRELFDTRELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPS MLBr_00135|M.leprae_Br4923 EMLCEVRELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPS MMAR_1762|M.marinum_M EMLAEVRELFDTAVLHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPS MUL_2005|M.ulcerans_Agy99 EMLAEVRELFDTAVLHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPS MAV_3108|M.avium_104 AMLAEVMELFAAGALTPLPVKAFDARCAADAYRFVSAARHIGKVVLTMPD TH_4621|M.thermoresistible__bu ELLETVYRLTADGVLPMPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVPH Mflv_0405|M.gilvum_PYR-GCK P-----------LQP-QPDRSYLITGGLGAIG-LHTAGYLAQLGAGDIVL MAB_0939|M.abscessus_ATCC_1997 P-----------LAP-RPDRTYLITGGLGAIG-LHTAAYLAQLGAGDIVL MSMEG_0408|M.smegmatis_MC2_155 P-----------LQP-QQDRSYLITGGLGAIG-LHTAAYLAQLGAGDIVL Mvan_1003|M.vanbaalenii_PYR-1 P-----------LQP-HGDRSYLITGGLGALG-LHAAAYLAQLGAGDIVL Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 A-----------LADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVL MLBr_00135|M.leprae_Br4923 A-----------LADGLAEGTVLITGASGAIGGVLARHMVSAYGVRHLVL MMAR_1762|M.marinum_M A-----------LADGLADATVLITGATGAVGAVLARHMLDAYGVRHLVL MUL_2005|M.ulcerans_Agy99 A-----------LADGLADATVLITGATGAVGAVLARHMLDGYGVRHLVL MAV_3108|M.avium_104 G-----------PAG-LSGGTALITGATGMAGAALARHLVARHRVPHLML TH_4621|M.thermoresistible__bu TGRADVVVPPEQASPFRSDGAYIVTGGMGGLG-LYLAGEMAAAGAGCIVL Mflv_0405|M.gilvum_PYR-GCK TSRRAPDAAAQQAIADIADRTKARLHVFTADVGVEADVAALLERIRAELP MAB_0939|M.abscessus_ATCC_1997 TSRRAPDTDAQRVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELP MSMEG_0408|M.smegmatis_MC2_155 TSRRDPDESAQRAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELP Mvan_1003|M.vanbaalenii_PYR-1 TGRRMPDAATERAISEIAERYHCRIHTFAADVGDESAVRDLLERIRTELP Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 ASRRGDRAEGAAELAADLTEAGAKGQVVACDVADRAAVAGLFAQLSREYP MLBr_00135|M.leprae_Br4923 ASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFP MMAR_1762|M.marinum_M ASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYP MUL_2005|M.ulcerans_Agy99 ASRRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYP MAV_3108|M.avium_104 VGRRGEAAPGMAELAAELRGAGASVSVLSCDVGDRDAVAAMLAQVPARYP TH_4621|M.thermoresistible__bu NGRSAPSGEALRTIEQLRAAGTEVIVECGXXX---------------RGQ Mflv_0405|M.gilvum_PYR-GCK PLAGVAHLAGVLDDALLSQQSVERFRTALAPKAFGAVHLDRLTRVDDLDF MAB_0939|M.abscessus_ATCC_1997 PLAGVAHLAGVLDDALLGQQSVERFRTTLAPKAFGAEYLDRLTKGDDLDF MSMEG_0408|M.smegmatis_MC2_155 PLAGIAHLAGVLDDALLSAQNPERFRTTLAPKAYGASHLDRLTRDDDLDF Mvan_1003|M.vanbaalenii_PYR-1 PLAGVAHLAGVLDDALLPQQSPERFRTTLAPKAFGAWHLHRLTRDTELEF Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 PVRGVIHAAGVLDDAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSM MLBr_00135|M.leprae_Br4923 PVRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLM MMAR_1762|M.marinum_M PVRGVIHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSM MUL_2005|M.ulcerans_Agy99 PVRGVIHAAGVLDDAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSM MAV_3108|M.avium_104 -LRSVFHAAGVLDDAVIASLTPARIDTVLRAKVDGAWNLHELTKDLDLSA TH_4621|M.thermoresistible__bu PVEVAVPTELRHADEHPDRRGAQLCDEFARGEQGAQRNQHRTDAGEGQRD Mflv_0405|M.gilvum_PYR-GCK FLVSSSVSSLFGSPGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWAR MAB_0939|M.abscessus_ATCC_1997 FIVSSSVSSLFGSPGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQ MSMEG_0408|M.smegmatis_MC2_155 FIVSSSVSSLFGSPGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQ Mvan_1003|M.vanbaalenii_PYR-1 FIVYSSGSSVLGSPGQANYATANAVLDGLVAHRKARGLPATGVNWGPWAQ Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 FVLCSSIAATVGSPGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQ MLBr_00135|M.leprae_Br4923 FVLCSSIAATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQ MMAR_1762|M.marinum_M FVLCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQ MUL_2005|M.ulcerans_Agy99 FVLCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQ MAV_3108|M.avium_104 FVVFSSMAGIVGAPGQGNYAAANSFLDALAIHRHAHGLPALSVAWGMWEE TH_4621|M.thermoresistible__bu AHPPGAVGHDQPDPG---------ALSDTGLDERGGQFPGVGVQIPVADP Mflv_0405|M.gilvum_PYR-GCK -GGMAS--SEAAAANISAQGLIPLEPSAALTAMAEVVANGTAQATVLKAN MAB_0939|M.abscessus_ATCC_1997 -GGMAS--SEAATANISAQGLIPLDPSAALAALAEVVANGTGQATILKAN MSMEG_0408|M.smegmatis_MC2_155 -GGMAS--SEAATANITAQGLIPLDPSAALHALAEVIANGSGQATVLKAN Mvan_1003|M.vanbaalenii_PYR-1 -GGMAT--SDAARANLGAQGLIPLEPTAALNALGEIVAHGIASAVVLKAN Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 PGGMTAHLSSRDLARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLD MLBr_00135|M.leprae_Br4923 PGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLD MMAR_1762|M.marinum_M SGGMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLD MUL_2005|M.ulcerans_Agy99 SGGMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLD MAV_3108|M.avium_104 PSAMTAHLEERDKARMSRAGLSALSTRQALDLLDDALLGEQPLVVGTRLD TH_4621|M.thermoresistible__bu GVGIDHRGAVRVDSGVP----------AQQGVDGEVVRHRTLSSVRSGRS Mflv_0405|M.gilvum_PYR-GCK -WQRAAKVLGSSRPPILDLVLPSAVG--------EITGDSELLKQLQEIP MAB_0939|M.abscessus_ATCC_1997 -WQRAAKVLGSSRPPILDLVLPSAVG--------EVTGDSELLKQLMEIP MSMEG_0408|M.smegmatis_MC2_155 -WQRAAKVLGSARPPILDLVLPSAAG--------EATGDSELLKQLMEIP Mvan_1003|M.vanbaalenii_PYR-1 -WQRAAKLLGATRPPILDHVLPSAVA--------AGPGDSALLKQLQDVP Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 RAALDARAQAGALPALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLA MLBr_00135|M.leprae_Br4923 RAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLA MMAR_1762|M.marinum_M RPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLS MUL_2005|M.ulcerans_Agy99 RPALEARAQAGGLPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLS MAV_3108|M.avium_104 RAALAQHRAA--LPPLLSELAGRPARRMLEHT--DMVSLTGLRARLAGMN TH_4621|M.thermoresistible__bu SRWTAPGSRCGSGRRYGGESCRRTTG--------PAAGAAARRGRTRRRR Mflv_0405|M.gilvum_PYR-GCK VPQRAGFVTEFLQKEVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNR MAB_0939|M.abscessus_ATCC_1997 VPQRAGFVTEFLQREVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNR MSMEG_0408|M.smegmatis_MC2_155 IPQRAGFVTEFLQREVQNFLRLASPP--AASSRFLDLGTDSLMAIELRNR Mvan_1003|M.vanbaalenii_PYR-1 EAQRGSFVTEHLQRELQQILGLAQPP--AATGRFLELGMDSLMAVELRNR Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 ADEQLELLVGLVCLQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNR MLBr_00135|M.leprae_Br4923 ANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNR MMAR_1762|M.marinum_M AGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNR MUL_2005|M.ulcerans_Agy99 AGERQDALVGLVCLQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNR MAV_3108|M.avium_104 PEQRQAELVELVCGNAAAVLG-HSTADVDPGDAFSDLGFDSLTAVELRNR TH_4621|M.thermoresistible__bu RPRRPPPPPDRVRHRAGPAHGPVRR------------------------- Mflv_0405|M.gilvum_PYR-GCK LHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP------- MAB_0939|M.abscessus_ATCC_1997 LHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESA MSMEG_0408|M.smegmatis_MC2_155 LHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA-------- Mvan_1003|M.vanbaalenii_PYR-1 LVGQFGSGFTITATAVFDYPTIGALAEYLAAQTPESTEEGTEMKTADPDG Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 LKTATG--LTLPPTVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVE MLBr_00135|M.leprae_Br4923 LKSATG--LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVE MMAR_1762|M.marinum_M LKSATG--LTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEE--KLPE MUL_2005|M.ulcerans_Agy99 FKSATG--LTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEE--KLPE MAV_3108|M.avium_104 LKIATG--LTLSPTVIFDHPTPAALAEHLGGQLTSAGPTPAAPAETAAPP TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QSESEPGPDVTE-------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAESGAGPAAASDAVSELKE------------------------------ MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 QPATVGHADVVLQTS----------------------------------- Rv2947c|M.tuberculosis_H37Rv -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 PAAAEVSVHA---------------------------------------- MLBr_00135|M.leprae_Br4923 PKVEEVSVHA---------------------------------------- MMAR_1762|M.marinum_M SDGEMVSVTA---------------------------------------- MUL_2005|M.ulcerans_Agy99 SDGEMVSVTA---------------------------------------- MAV_3108|M.avium_104 DRSSRIDEVVSELQTLLTQPGLSPGDRAQLVTRLQSLLSTPPQPSGHPEF TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --------------------------- MAB_0939|M.abscessus_ATCC_1997 --------------------------- MSMEG_0408|M.smegmatis_MC2_155 --------------------------- Mvan_1003|M.vanbaalenii_PYR-1 --------------------------- Rv2947c|M.tuberculosis_H37Rv --------------------------- Mb2971c|M.bovis_AF2122/97 --------------------------- MLBr_00135|M.leprae_Br4923 --------------------------- MMAR_1762|M.marinum_M --------------------------- MUL_2005|M.ulcerans_Agy99 --------------------------- MAV_3108|M.avium_104 PEDAFDDDIATATDSQLFAILDDEAGP TH_4621|M.thermoresistible__bu ---------------------------