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MTTSGESADQQNDKLFRYLKKVAVELDEARARLREYEQRATEPVAVVGIGCRFPGGADGPEGLWDLVSQG RDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTRWGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSW EALEHAGIDPMSLRGSSTGVFTGIFAPSYGGKDVGALQGYGLTGSPVSVASGRVAYVLGLEGPALSVDTA CSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFAAAADGTGWGEGAGV LVLERLSDAQRNGHNVLAVVRGSAINQDGASNGLTAPNGLAQQRVIQAALANCGLTSADVDVVEAHGTAT TLGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHGLMPASLHVDEPSKR VDWESGAVSVLAEARDWPDAGRPRRAGVSSFGISGTNAHVILEEAPAPEAVPDSESNKGEPSLPVVPWVI SARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAGRSAFEHRAVVVGADRQQLLTGLATLADGAPGAGV VTGQAGSVGKTAVVFPGQGSQRIGMARELHDQLPVFAEAFDAVADELDRHLRIPLREVMWGSDAALLDST EFAQPALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLTLADAAMLVVARGRLMQALPAGGAM VAVAAAEDEVLPSLTDGVGIAAINAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPML EEFARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQLHTLGVTHFVEVGP GSGLTGSIEQSLAPAEAVVVSMLGKDRPEVASVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQR RRFWEVPGADGPADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVIGGVVLFPGAGF VELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVGAADDSGNRALSVYSRGDQSEDWLLNAEGML GVEAASSGADLSVWPPEGAESVDISDGYAQLADRGYAYGPGFQGLVGVWRRDSELFAEVVAPSGVAVDKM GMHPVVLDAVLHALGLTAEQNPDSDETKLPFCWRGVSLHAGGAGRVRARLTMSGPDSISVEIADAAGLPV LTVGALVTRAMSAAQLRAAVAAAGGGAPDQGPLDVIWSPIPLSGSGTNGSAQPAVVSWADFCAGGDGGAA GDAGVVVWEPNPAGEDVVGSVYAATHAALEVLQSWFDGDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGI VRSAQAENPGRIVLVDADAAVEAAELVAVGEPQLVVRSGAAHAARLAPAAPLLAVPADESAWRLAAGGGG TLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAALGMYPGEAPPLGAEGAGVVLEVGPQVSGVAV GDSVMGFLGGAGPLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHAGTGGVG MAAVQLARHWGVEIFVTASRGKWDTLRAMGFDDDHIGDSRTLDFEEKFLAVTDGRGVDVVLDSLAGDFVD ASLRLLVRGGRFLEMGKTDIRDADKIAANYPGVWYRAFDLSEAGPVRMQEMLAEVRELFDTAVLHRLPVT TWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADATVLITGATGAVGAVLARHMLDAYGVRHLVLAS RRGDRAEGAAELAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGVLDDAVISSLTP ERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGSPGQGNYSAANSFLDGLAAHRQAAGLAGIS VAWGLWEQSGGMAAHLSSRDLARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGG LPPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGLVCLQAAAVLGRPSPEDIDPEA GFQDLGFDSLTAVELRNRLKSATGLTLPPTVIFDHPTPTAIAEYVGRQIPDSQATQAEEEKLPESDGEMV SVTA
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1762 | pks15/1 | - | 100% (2104) | polyketide synthase Pks15/1 |
M. marinum M | MMAR_3099 | - | 0.0 | 63.09% (2081) | polyketide synthase and peptide synthetase |
M. marinum M | MMAR_2472 | pks8 | 0.0 | 60.65% (2079) | polyketide synthase, Pks8 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2971c | pks1 | 0.0 | 81.95% (2094) | polyketide synthase PKS1 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 39.35% (2160) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2946c | pks1 | 0.0 | 81.23% (1604) | polyketide synthase PKS1 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 79.22% (2113) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 39.44% (2160) | polyketide synthase |
M. avium 104 | MAV_3108 | - | 0.0 | 62.05% (2079) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 38.94% (2157) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 35.01% (1865) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 99.43% (2104) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_0269 | - | 0.0 | 39.87% (2147) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDVLREGRDAISEVPADR Mvan_0269|M.vanbaalenii_PYR-1 MGSAEHPNGPAPRFAIVGYAARFPGAPDADAFWDVLREGRDAISDVPRDR Mflv_0405|M.gilvum_PYR-GCK MGSAAHQGESAHRFAIVGYAGRFPGARDAESFWELLADGRDAISEVPEDR MSMEG_0408|M.smegmatis_MC2_155 MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPFFGMSTREVRLMDPQH Mvan_0269|M.vanbaalenii_PYR-1 WDAEEFFDPEPGAPGKVVTRRAGFVDDVTGFDAPFFGMSTREVRMMDPQH Mflv_0405|M.gilvum_PYR-GCK WDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPFFGMSTREVRLMDPQH MSMEG_0408|M.smegmatis_MC2_155 WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATHDYLGMASDELTFPEI Mvan_0269|M.vanbaalenii_PYR-1 RLLLETAWRAVEHSGTAPTALAGSNTGVFVGLATHDYLGMASDELTYPEI Mflv_0405|M.gilvum_PYR-GCK RLLLETAWRAIEHSGTAPSELANTNTGVFVGLATHDYLGMASDELSYPEI MSMEG_0408|M.smegmatis_MC2_155 RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACSSSLVAIHQACQALQL Mvan_0269|M.vanbaalenii_PYR-1 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mflv_0405|M.gilvum_PYR-GCK EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL MSMEG_0408|M.smegmatis_MC2_155 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GECDLALAGGANVLLTPATMITFSHAHMLAPDGKCKTFDAAADGYVRGEG Mvan_0269|M.vanbaalenii_PYR-1 GECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG Mflv_0405|M.gilvum_PYR-GCK GECDLALAGGANVILTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG MSMEG_0408|M.smegmatis_MC2_155 NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA Mvan_0269|M.vanbaalenii_PYR-1 CGVIVIKRLEDAVRDGDRIRAVIRGSSINQDGASGGLTVPNGVAQQRVIA Mflv_0405|M.gilvum_PYR-GCK CGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIG MSMEG_0408|M.smegmatis_MC2_155 CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLI Mvan_0269|M.vanbaalenii_PYR-1 DALKRSDLEPKDVGYLEAHGTGTSLGDPIEAQAAGAVLGAGREPSRPLLI Mflv_0405|M.gilvum_PYR-GCK DALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAGAALGPGREPQRPLLI MSMEG_0408|M.smegmatis_MC2_155 DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLP Mvan_0269|M.vanbaalenii_PYR-1 GSAKTNIGHLEAAAGIAGVIKVILSLEHRTLPKHLNFENPSPHIPWDRLA Mflv_0405|M.gilvum_PYR-GCK GSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLP MSMEG_0408|M.smegmatis_MC2_155 GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEVVREARPWGRN---GRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVE Mvan_0269|M.vanbaalenii_PYR-1 VEVVKETIPWERD---GGPRIAGVSSFGFAGTNAHVILEEAP--EQAAAP Mflv_0405|M.gilvum_PYR-GCK VEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAHVILEEAP---LAAEP MSMEG_0408|M.smegmatis_MC2_155 IEVVRETVPWQRN---GKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATT TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PPAPAGGRKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAG Mvan_0269|M.vanbaalenii_PYR-1 GPVQQPDRRFSLLPLSARTPAALTQLAGQYRDWWTAHPEATLADVCFTAG Mflv_0405|M.gilvum_PYR-GCK AQESVDDGRFTLLPLSARTPAALMAVADRYRDWLVANPDATLADLCFTAG MSMEG_0408|M.smegmatis_MC2_155 EPVE-DPRRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAG TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGRAHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWL Mvan_0269|M.vanbaalenii_PYR-1 AGRAHLEHRAALVVNSAESAVELLGALADDRPAPGLVRGESHDTPKTAWL Mflv_0405|M.gilvum_PYR-GCK TARSHLEHRAALVVNTREAALDLLGALADDRPAPGLVRGESHDTPKTAWL MSMEG_0408|M.smegmatis_MC2_155 TARAHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FTGQGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD- Mvan_0269|M.vanbaalenii_PYR-1 FTGQGSQYPGMARELYDTEPVFAETLNRCAEAVADVLEKPLLDVIFDAE- Mflv_0405|M.gilvum_PYR-GCK FTGQGSQYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDG MSMEG_0408|M.smegmatis_MC2_155 FTGQGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD- TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 --GPEAEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYS Mvan_0269|M.vanbaalenii_PYR-1 --ADDAEKTLQNTCYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYS Mflv_0405|M.gilvum_PYR-GCK VLDTDSNETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYA MSMEG_0408|M.smegmatis_MC2_155 ELDGDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYS TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEF Mvan_0269|M.vanbaalenii_PYR-1 AACVAGVFSLTDGARLMAERGRLFGSLPEGGRMVAVFTTAERAEAMTDEF Mflv_0405|M.gilvum_PYR-GCK AACVAGVLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEY MSMEG_0408|M.smegmatis_MC2_155 AACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEY TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PSLSVAAYNGANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALL Mvan_0269|M.vanbaalenii_PYR-1 PSLSVAAYNGTNTVLSGPAGDLEKAVATLSADGVRCDWLDTSHAFHSALL Mflv_0405|M.gilvum_PYR-GCK PALSVAAYNGANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALL MSMEG_0408|M.smegmatis_MC2_155 PSLSVAAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DPILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQP Mvan_0269|M.vanbaalenii_PYR-1 DPILDDFESYANQFDFAAPQRILIDNRTGTALGRSVQLDGTYWRRHARQP Mflv_0405|M.gilvum_PYR-GCK DPILDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQP MSMEG_0408|M.smegmatis_MC2_155 DPILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQP TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRR Mvan_0269|M.vanbaalenii_PYR-1 VEFAKSVRTLAEMNCKLLVEIGPRPVLTAAALGAWPDPATAPRVIASLRR Mflv_0405|M.gilvum_PYR-GCK VEFAKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRR MSMEG_0408|M.smegmatis_MC2_155 VEFAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRP TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NTADHRQITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFS Mvan_0269|M.vanbaalenii_PYR-1 TAADHRQITEAVADAYVLGHLPEFGAFRDAGARKLDLPTYPFEHRQYWFR Mflv_0405|M.gilvum_PYR-GCK TTADQRQITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFS MSMEG_0408|M.smegmatis_MC2_155 TTADHRQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFS TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTL Mvan_0269|M.vanbaalenii_PYR-1 DNQDPD----GSEALQPRTPSTEAVRLLEDGRIEELATLLDGAAGDQQTL Mflv_0405|M.gilvum_PYR-GCK DSREPV------AAAPQRGARTETVRLLEDGRIEELAALLGGTVDDPFTF MSMEG_0408|M.smegmatis_MC2_155 DNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVA Mvan_0269|M.vanbaalenii_PYR-1 DVLSRLAAQHNQQRSSQSITNDRYEIRWEQSAAALSGAETDEVSSWILVG Mflv_0405|M.gilvum_PYR-GCK DVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVG MSMEG_0408|M.smegmatis_MC2_155 RVLNKLAARHNQQRSTHVDPDARYEIRWDAIAS--AAASTGAAADWILVG TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALR Mvan_0269|M.vanbaalenii_PYR-1 DDTEATRPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAAEDSTLR Mflv_0405|M.gilvum_PYR-GCK DDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLR MSMEG_0408|M.smegmatis_MC2_155 DDTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELY TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVHVAALAGQ----GSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIW Mvan_0269|M.vanbaalenii_PYR-1 IVHVGGLDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAELRTPIW Mflv_0405|M.gilvum_PYR-GCK IVHVAALDAA---ESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMW MSMEG_0408|M.smegmatis_MC2_155 VVHIAAGDGA-----AAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIW TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDE Mvan_0269|M.vanbaalenii_PYR-1 VVTRRAQHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLADGTADE Mflv_0405|M.gilvum_PYR-GCK LVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDE MSMEG_0408|M.smegmatis_MC2_155 LVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSG-ADTE TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSD Mvan_0269|M.vanbaalenii_PYR-1 WSRLLNRITAPHGPAVREDQIALRDHAVYVPRLVRRAGRPAGKPLQLRDD Mflv_0405|M.gilvum_PYR-GCK WSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLRAD MSMEG_0408|M.smegmatis_MC2_155 WPRLIARITSPRD---GEDQIALRGDAVYAPRLVRRTGEPSDTPLPVRED TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAAQ Mvan_0269|M.vanbaalenii_PYR-1 ATYLVTGGLGSIGLEIAGYLAAHGARHLVLTSRRAPGDATQQRIDALGAQ Mflv_0405|M.gilvum_PYR-GCK ATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEALRER MSMEG_0408|M.smegmatis_MC2_155 RTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQ TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 G-CEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDL Mvan_0269|M.vanbaalenii_PYR-1 HSCQIRVVAADVADAHDVARLLAAVAAELPPLAGIVHAAGEIGTTPLVSL Mflv_0405|M.gilvum_PYR-GCK HGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADL MSMEG_0408|M.smegmatis_MC2_155 YACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGL TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTA Mvan_0269|M.vanbaalenii_PYR-1 EDSEVDRVFAGKVWGAWHLSEAAADLQ--LDFFLGTSSIASVWGGYGQTA Mflv_0405|M.gilvum_PYR-GCK DDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAA MSMEG_0408|M.smegmatis_MC2_155 DDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTA TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 YSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKT Mvan_0269|M.vanbaalenii_PYR-1 YGAANAFLDGLAWRLREQGISGVSINFGPWSAGMADAESRARLDQRGVRT Mflv_0405|M.gilvum_PYR-GCK YGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKT MSMEG_0408|M.smegmatis_MC2_155 YGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRT TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LSPTDALAGLADVVAASGS-NAVQGVIARIDWARFLPLYQQAGKRGFLAE Mvan_0269|M.vanbaalenii_PYR-1 LSPADALAGLADVVTAAEAPGPAQGIVARIDWERFLPLYQQAGRRAFLAE Mflv_0405|M.gilvum_PYR-GCK LSPADALAGLSDAVISAAP----HPVVARVDWSRFLPLYQQAGRRGFLAE MSMEG_0408|M.smegmatis_MC2_155 LSPAEALAGMADVVAGPVQ-----GVVAKIDWSRFLPLYQQAGRRAFLSE TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------MTTSGESADQQNDKLFRYLKKVAVE MUL_2005|M.ulcerans_Agy99 -------------------------MTTSGESADQQNDKLFRYLKKVAVE Mb2971c|M.bovis_AF2122/97 --------------------MIEEQRTMSVEGADQQSEKLFHYLKKVAVE Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------MTASVEGADQKSEKLISYLKKVVVE MAV_3108|M.avium_104 ---------------------------------MPGTEQHLDYLKRLTAD MAB_0939|M.abscessus_ATCC_1997 LDREVPSHLAGV--AGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAE Mvan_0269|M.vanbaalenii_PYR-1 LEREVPDTAP----AATPSGRTELVERLTNAPVQQRKKLLTDYLRTAVAE Mflv_0405|M.gilvum_PYR-GCK LERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAE MSMEG_0408|M.smegmatis_MC2_155 LESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAE TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M LDEARARLREYEQ------------------------------------- MUL_2005|M.ulcerans_Agy99 LDEARARLREYEQ------------------------------------- Mb2971c|M.bovis_AF2122/97 LDETRARLREYEQ------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LDETRARLREYEQ------------------------------------- MAV_3108|M.avium_104 LRRTRRRVAELEG------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPR Mvan_0269|M.vanbaalenii_PYR-1 ITRVDATEIREDAGFFDLGMDSLMAVELRRRIEQGVGREIPATLAMDHPR Mflv_0405|M.gilvum_PYR-GCK VTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPR MSMEG_0408|M.smegmatis_MC2_155 VTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPR TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M ---------------------------------RATEPVAVVGIGCRFPG MUL_2005|M.ulcerans_Agy99 ---------------------------------RATEPVAVVGIGCRFPG Mb2971c|M.bovis_AF2122/97 ---------------------------------RATEPVAVVGIGCRFPG Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 ---------------------------------RATEPVAVVGIGCRFPG MAV_3108|M.avium_104 ---------------------------------RLSEPVAVVGMACRYAG MAB_0939|M.abscessus_ATCC_1997 ISDVADYLLGDVLGLAEQA--KPAAQLASAVTGRTDEPIAIVAVSCRFPG Mvan_0269|M.vanbaalenii_PYR-1 LSDVADYLLGEVLGLAEQAPAKAGSQPASAAANRTDEPIAIVAVSCRFPG Mflv_0405|M.gilvum_PYR-GCK LSDAADYLLGDVLGLTEAA---TAPKAATVVSTAADEPIAIVAVSCRFPG MSMEG_0408|M.smegmatis_MC2_155 LSDAADYLLVEVLGLGEQT----NVRQASTVTARTDDPIAVVAVSCRFPG TH_4621|M.thermoresistible__bu ---------------------------VNIVGDTPVNAVAVIGMACRLPG MMAR_1762|M.marinum_M GADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTRWGA MUL_2005|M.ulcerans_Agy99 GADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTRWGA Mb2971c|M.bovis_AF2122/97 GVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTYTRWGA Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 GVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGA MAV_3108|M.avium_104 GVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTRQGS MAB_0939|M.abscessus_ATCC_1997 -APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGG Mvan_0269|M.vanbaalenii_PYR-1 -APDPEAFWEVLAGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRFGG Mflv_0405|M.gilvum_PYR-GCK -APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGG MSMEG_0408|M.smegmatis_MC2_155 -APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGG TH_4621|M.thermoresistible__bu GIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVPGRTVSRWGA MMAR_1762|M.marinum_M FVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDPMSLRG MUL_2005|M.ulcerans_Agy99 FVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDPMSLRG Mb2971c|M.bovis_AF2122/97 FLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLSLRG Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 FLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRG MAV_3108|M.avium_104 FLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSALRG MAB_0939|M.abscessus_ATCC_1997 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRG Mvan_0269|M.vanbaalenii_PYR-1 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGLAPADLRG Mflv_0405|M.gilvum_PYR-GCK FLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRG MSMEG_0408|M.smegmatis_MC2_155 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRG TH_4621|M.thermoresistible__bu FLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTPADVEG MMAR_1762|M.marinum_M SSTGVFTGIFAPSYG----GKDVGALQGYGLTGSPVSVASGRVAYVLGLE MUL_2005|M.ulcerans_Agy99 SSTGVFTGIFAPSYG----GKDVGALQGYGLTGSPVSVASGRVAYVLGLE Mb2971c|M.bovis_AF2122/97 SATGVYTGIFAASYG----NRDTGGLQGYGLTGTSISVASGRVSYVLGLQ Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 SATGVFTGIFAPSYG----SRDTGGLQGYGLTGTAVSVASGRVSYVLGLE MAV_3108|M.avium_104 TATGVFAGVIHAGYG----GEVKGELEGYGLTGSTLSVTSGRVSYVLGLE MAB_0939|M.abscessus_ATCC_1997 SRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFE Mvan_0269|M.vanbaalenii_PYR-1 SRTGIFVGVAANEYAHLLSSESIEKIEPHFITGNALNAISGRVAFALGLE Mflv_0405|M.gilvum_PYR-GCK SRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLE MSMEG_0408|M.smegmatis_MC2_155 SRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFE TH_4621|M.thermoresistible__bu SSTGVFVGLSHDDYALLT-SDAGALEEAYGFTGSAFSMASGRIAYRLGVH MMAR_1762|M.marinum_M GPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFS MUL_2005|M.ulcerans_Agy99 GPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFVGFS Mb2971c|M.bovis_AF2122/97 GPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFS Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 GPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFS MAV_3108|M.avium_104 GPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFVEFS MAB_0939|M.abscessus_ATCC_1997 GPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAAS Mvan_0269|M.vanbaalenii_PYR-1 GPAVAVDTACSSALVAVHQACQALHSGDCDLALAGGVNVLLSPVTSVAAS Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAAS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAAS TH_4621|M.thermoresistible__bu GPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPRKYTSAS MMAR_1762|M.marinum_M RQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAVVR MUL_2005|M.ulcerans_Agy99 RQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLAVVR Mb2971c|M.bovis_AF2122/97 RQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLAVVR Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 RQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVR MAV_3108|M.avium_104 RQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWAVLR MAB_0939|M.abscessus_ATCC_1997 RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIP Mvan_0269|M.vanbaalenii_PYR-1 RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLGDAVRDGDRVCAVIP Mflv_0405|M.gilvum_PYR-GCK RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIA MSMEG_0408|M.smegmatis_MC2_155 RARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIP TH_4621|M.thermoresistible__bu GLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVR MMAR_1762|M.marinum_M GSAINQDGASNGLTAPNGLAQQRVIQAALANCGLTSADVDVVEAHGTATT MUL_2005|M.ulcerans_Agy99 GSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVEAHGTATT Mb2971c|M.bovis_AF2122/97 GSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDVVEAHGTATT Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 GSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATT MAV_3108|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGTGTV MAB_0939|M.abscessus_ATCC_1997 GSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTP Mvan_0269|M.vanbaalenii_PYR-1 SSAVNQDGASSGLTVPNGGAQQRLIGMALARAGLSGGDVDYLEAHGTGTP Mflv_0405|M.gilvum_PYR-GCK GSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTP MSMEG_0408|M.smegmatis_MC2_155 ASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTP TH_4621|M.thermoresistible__bu GTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTP MMAR_1762|M.marinum_M LGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAGVAGVIKMVQ MUL_2005|M.ulcerans_Agy99 LGDPIEAEALLATYGQGRPTDQPLWVGSIKSNMGHTQAAAGVAGVIKMVQ Mb2971c|M.bovis_AF2122/97 LGDPIEAQALLSTYGQGRPAEQPLWVGSIKSNMGHTQAAAGVAGVIKMVQ Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 LGDPIEAQALLATYGQGRPADQPLWVGSIKSNMGHTQAAAGVAGVIKMVQ MAV_3108|M.avium_104 LGDPIEAQALLATYGQDRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQ MAB_0939|M.abscessus_ATCC_1997 LGDPIEVQAAAAAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVL Mvan_0269|M.vanbaalenii_PYR-1 LGDPIEVQAAAAAYGASRDADRPLLMGSVKTNIGHLESASGAAGLIKVVL Mflv_0405|M.gilvum_PYR-GCK LGDPIEVQAAAAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVL MSMEG_0408|M.smegmatis_MC2_155 LGDPIEVQAAAAAYGAGRDADRPLLMGSVKTNIGHTESASGAAGLIKVVL TH_4621|M.thermoresistible__bu VGDPIEYNSLTQVYGKTG----PCALTSVKTNFGHAESAAGALGMMKAIL MMAR_1762|M.marinum_M AMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPD-AGRPRRAGVSS MUL_2005|M.ulcerans_Agy99 AMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWPD-AGRPRRAGVSS Mb2971c|M.bovis_AF2122/97 AMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWSV-DGRPRRAAVSS Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 AMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSV-EGRPRRAGVSS MAV_3108|M.avium_104 ALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWPE-HGGPRRAGVSS MAB_0939|M.abscessus_ATCC_1997 SLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQA-NGRPRRAGVSS Mvan_0269|M.vanbaalenii_PYR-1 SLQHNLLPQSLHFENPSPHIPWDSLPVRVVDKAIPWQA-DGRPRRAGVSS Mflv_0405|M.gilvum_PYR-GCK SLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQP-NGRPRRAGVSS MSMEG_0408|M.smegmatis_MC2_155 SLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQT-NGRVRRAGVSS TH_4621|M.thermoresistible__bu ALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREGCPRRAAVSS MMAR_1762|M.marinum_M FGISGTNAHVILEEAPAPEAVPDSES-------NKGE---PSLPVVPWVI MUL_2005|M.ulcerans_Agy99 FGISGTNAHVILEEAPAPEAVPDSES-------NKGE---PSLPVVPWVI Mb2971c|M.bovis_AF2122/97 FGISGTNAHLILEEAPVPAPAEAPVE-------ASESTGGPRPSMVPWVI Rv2946c|M.tuberculosis_H37Rv ------------------------------------------------MI MLBr_00135|M.leprae_Br4923 FGISGTNAHVILEEAPTPVEASYSTA-------DQQ-----RLSVVPWVV MAV_3108|M.avium_104 FGISGTNAHVIVEQAPAAAETEAAPA-------SSTMP----DAVVPWVV MAB_0939|M.abscessus_ATCC_1997 FGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQSAPVSVLPL Mvan_0269|M.vanbaalenii_PYR-1 FGFTGTNAHVLIEEAPLPQAAD----------PVEEPDT-RALPVGVLAL Mflv_0405|M.gilvum_PYR-GCK FGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPL MSMEG_0408|M.smegmatis_MC2_155 FGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLAL TH_4621|M.thermoresistible__bu YGMSGTNVHAVLEQAPEPVQRP------------EESADTDAAGPLVFAL : MMAR_1762|M.marinum_M SARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSAFEHRAVVVG MUL_2005|M.ulcerans_Agy99 SARSAEALTAQAGRLLAHVQAD-PQSNPVDIGFSLAG-RSAFEHRAVVVG Mb2971c|M.bovis_AF2122/97 SARSAEALTAQAGRLMAHVQAN-PGLDPIDVGCSLAS-RSVFEHRAVVVG Rv2946c|M.tuberculosis_H37Rv SARSAEALTAQAGRLMAHVQAN-PGLDPIDVGCSLAS-RSVFEHRAVVVG MLBr_00135|M.leprae_Br4923 SGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSVFEHRAVVVG MAV_3108|M.avium_104 SARSAEALAGQARRLLDHVTAD-AQASPLDVGWSLVSTRAVFEHRAVVVG MAB_0939|M.abscessus_ATCC_1997 SARSPEALAAVAQRYESWLAAH-PDVDLEDVCLTAGRGRSHFEHRAALVV Mvan_0269|M.vanbaalenii_PYR-1 SARSPEALTALAQRYEAWLSAH-PDADLADVCRTAGTGRSHFEHRAALVV Mflv_0405|M.gilvum_PYR-GCK SARSPEALVALAQRYETWLTAH-PEADLADVCRTAGTGRSHFEHRAALVV MSMEG_0408|M.smegmatis_MC2_155 SARSPEALVELARRYDDWLSAT-PGLDIADVCHTAGVGRSHFEYRAALVV TH_4621|M.thermoresistible__bu SSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVIA *. *. * * * : * *: : *: *:.:: MMAR_1762|M.marinum_M ADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARE MUL_2005|M.ulcerans_Agy99 ADRQQLLTGLATLADGAPGAGVVTGQAGSVGKTAVVFPGQGSQRIGMARE Mb2971c|M.bovis_AF2122/97 ASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRE Rv2946c|M.tuberculosis_H37Rv ASREQLIAGLAGLAAGEPGAGVAVGQPGSVGKTVVVFPGQGAQRIGMGRE MLBr_00135|M.leprae_Br4923 ESREQLIAGLAGLAVGESGAGVAIGQAAPLGKTVVVFPGQGAQRIGMGRE MAV_3108|M.avium_104 RERGALATGLAGLASGRPGPATVVGRARSTGKTVLVFPGQGSQTLGMGRQ MAB_0939|M.abscessus_ATCC_1997 DSIQTAREGLLELAQNRLRPGVVRGEHTNHPTTAWLFTGQGSQYPGMARE Mvan_0269|M.vanbaalenii_PYR-1 DSVAAAREGLAELAQNRLRPGVVRGEHTHHPTTAWLFTGQGSQFPGMARE Mflv_0405|M.gilvum_PYR-GCK DSVESARIALTDLAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARE MSMEG_0408|M.smegmatis_MC2_155 DSVERAREGLAALAEGRTPAGVVRGEHVHRPTTAWLFTGQGSQYPGMARE TH_4621|M.thermoresistible__bu DGVEALTAGLREVADGDAPYQPAVG--MDDKAPVWVFSGQGSQWAGMGAE .* :* . . * .. :*.***:* **. : MMAR_1762|M.marinum_M LHDQLPVFAEAFDAVADELDRHLRIPLREVMWGSD-------AALLDSTE MUL_2005|M.ulcerans_Agy99 LHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSD-------VALLDSTE Mb2971c|M.bovis_AF2122/97 LYGELPVFAQAFDAVADELDRHLRLPLRDVIWGAD-------ADLLDSTE Rv2946c|M.tuberculosis_H37Rv LYGELPVFAQAFDAVADELDRHLRLPLRDVIWGAD-------ADLLDSTE MLBr_00135|M.leprae_Br4923 LCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD-------AGLLDSTE MAV_3108|M.avium_104 LYERFEVFAGALDEAVAVVDEHSRLSVREVMWGAD-------PELLQSTE MAB_0939|M.abscessus_ATCC_1997 LFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTS Mvan_0269|M.vanbaalenii_PYR-1 LFETEPVFADAVTRCADAVKDILPRPLLEVLFAADRESG----EALRHTS Mflv_0405|M.gilvum_PYR-GCK LFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTS MSMEG_0408|M.smegmatis_MC2_155 LFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRETA----DLLQHTS TH_4621|M.thermoresistible__bu LLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET---------VTGID * *** . : .: :.: . : . MMAR_1762|M.marinum_M FAQPALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLTLADAA MUL_2005|M.ulcerans_Agy99 FAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLTLVDAA Mb2971c|M.bovis_AF2122/97 FAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAA Rv2946c|M.tuberculosis_H37Rv FAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLTLADAA MLBr_00135|M.leprae_Br4923 FAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAA MAV_3108|M.avium_104 FAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLSLRDAA MAB_0939|M.abscessus_ATCC_1997 FAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGA Mvan_0269|M.vanbaalenii_PYR-1 FAQPAIFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSLEDGA Mflv_0405|M.gilvum_PYR-GCK FAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGA MSMEG_0408|M.smegmatis_MC2_155 FAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGA TH_4621|M.thermoresistible__bu RVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDGV .*.::*..::. . .: *. *:***:*: :** .**.:: *.. MMAR_1762|M.marinum_M MLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG----VGIAAINAPK MUL_2005|M.ulcerans_Agy99 MLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG----VGIAAINAPK Mb2971c|M.bovis_AF2122/97 MLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEG----VGIAAINAPE Rv2946c|M.tuberculosis_H37Rv MLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEG----VGIAAINAPE MLBr_00135|M.leprae_Br4923 MLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG----VGIAAINAPE MAV_3108|M.avium_104 RLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGG----VSIAAVNGPD MAB_0939|M.abscessus_ATCC_1997 RLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFPR--VSVGAYNGP- Mvan_0269|M.vanbaalenii_PYR-1 RLMAERGRMFGSLPEGGRMVAVFTDAKLVEEIAGDFPR--VSVGAYNGP- Mflv_0405|M.gilvum_PYR-GCK RLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFPR--VSVGAYNGP- MSMEG_0408|M.smegmatis_MC2_155 RLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFPR--VSVGAYNGP- TH_4621|M.thermoresistible__bu KVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPE :: *. : :. .* * *: . * * :.. .* MMAR_1762|M.marinum_M SVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIA MUL_2005|M.ulcerans_Agy99 SVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEFARIA Mb2971c|M.bovis_AF2122/97 SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVA Rv2946c|M.tuberculosis_H37Rv SVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEFARVA MLBr_00135|M.leprae_Br4923 SVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVA MAV_3108|M.avium_104 AVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGFAAAA MAB_0939|M.abscessus_ATCC_1997 NTVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYA Mvan_0269|M.vanbaalenii_PYR-1 NTVLSGPGEDLEQIVDRFGDDGVRCTWLQTSHAFHSELLDPVLDEFESYA Mflv_0405|M.gilvum_PYR-GCK NTVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYA MSMEG_0408|M.smegmatis_MC2_155 NTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYA TH_4621|M.thermoresistible__bu STVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEIL .*:.* .* : .. * ** ::*:*: : MMAR_1762|M.marinum_M AQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQL MUL_2005|M.ulcerans_Agy99 AQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADSARQL Mb2971c|M.bovis_AF2122/97 ARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPVRFADSARHL Rv2946c|M.tuberculosis_H37Rv ARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPVRFADSARHL MLBr_00135|M.leprae_Br4923 AQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRFVDSARHL MAV_3108|M.avium_104 AGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPVRFVDGVRLA MAB_0939|M.abscessus_ATCC_1997 AQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPVQFAESVRTV Mvan_0269|M.vanbaalenii_PYR-1 AQFQFATPTLPLVCNRTGTVLTAQT-PLDAQYWRRHSRQPVQFAESVRTV Mflv_0405|M.gilvum_PYR-GCK AQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQFAESVRTV MSMEG_0408|M.smegmatis_MC2_155 AQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQFAESVRTV TH_4621|M.thermoresistible__bu ADLQPMTPTVPYYSATSYDPREKP--VCDADYWVDNLRHEVRFAAAVQAA * .: * : . : :** : : *:*. ..: MMAR_1762|M.marinum_M HTLGVTHFVEVGPGSGLTGSIEQSLAP--AEAVVVSMLGKDRPEVASVLT MUL_2005|M.ulcerans_Agy99 HTLGVTHFVEVGPGSGLTGSIEQSLAP--AEAVVVSMLGKDRPEVASVLT Mb2971c|M.bovis_AF2122/97 QTLGATHFIEAGPGSGLTGSIEQSLAP--AEAMVVSMLGKDRPELASALG Rv2946c|M.tuberculosis_H37Rv QTLGATHFIEAGPGSGLTGSIEQSLAP--AEAMVVSMLGKDRPELASALG MLBr_00135|M.leprae_Br4923 QTLGATHFIESGPSSGLMGAIEQSLAP--AEAVVVSMMGKDRPELASVLG MAV_3108|M.avium_104 ESQGAGVFLEVGPGAALTSAVEQSLTS--DRAMSVVTMPKGRPEVDSLLT MAB_0939|M.abscessus_ATCC_1997 AALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPRAIVSLRKGVEDRRQIAD Mvan_0269|M.vanbaalenii_PYR-1 AALGCSVLMEIGPQPVLTGSAVQVWPEHLAAPRAIVSLRKGVSDRRQITE Mflv_0405|M.gilvum_PYR-GCK AALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIASLRKGVADRRQIAD MSMEG_0408|M.smegmatis_MC2_155 AALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPRAVASLRKGVADRRQIAD TH_4621|M.thermoresistible__bu LEDGFRVFGELSPHPLLTRAVEQTARGLDMPVAALPAMRREQEMPHGVRT * : * .* . * : * : : : MMAR_1762|M.marinum_M AFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGADGPADA MUL_2005|M.ulcerans_Agy99 AFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGADGPADA Mb2971c|M.bovis_AF2122/97 AAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADA Rv2946c|M.tuberculosis_H37Rv AAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADGPADA MLBr_00135|M.leprae_Br4923 AAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGTASV MAV_3108|M.avium_104 AAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLSGDAVGSANI MAB_0939|M.abscessus_ATCC_1997 ALASAYVSGHRPNFAALQR-HPRRTVELPTYPFQRRRFWPKS---SGTAI Mvan_0269|M.vanbaalenii_PYR-1 ALAAAYVGGHRPDFGALYR-RPGRAVALPTYPFQRRRFWPKT---SGITT Mflv_0405|M.gilvum_PYR-GCK ALAAAYIGGHKPDFAALHE-QRGVRLELPTYPFQRRRFWPKS---AGMAI MSMEG_0408|M.smegmatis_MC2_155 ALASAYVGGHRPDFAAVHR-QPRRPVELPTYPFQRRRFWPKA---SSIAV TH_4621|M.thermoresistible__bu MVGDLFAAGAAVDFAALYP--SGRLVDAPLPTWTRRKLVLSR--ENGEQQ . : * : * : * .: **:: MMAR_1762|M.marinum_M TGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALADQPWLADHVIGGVVL MUL_2005|M.ulcerans_Agy99 TGLGLGGAEHALLGAVVERPDSGG-VVLTGRLALADQPWLADHVIGGVVL Mb2971c|M.bovis_AF2122/97 AGLGLGATEHALLGAVVERPDSDE-VVLTGRLSLADQPWLADHVVNGVVL Rv2946c|M.tuberculosis_H37Rv AGLGLGATEHALLGAVVERPDSDE-VVLTGRLSLADQPWLADHVVNGVVL MLBr_00135|M.leprae_Br4923 SGLGLGSTEHALLGAVVERPDSGG-VVLTGRLSLANQPWLADHVIGGVVL MAV_3108|M.avium_104 ASLGLAEAEHPLLGAVLDRPDSGG-VVLTGRLSTAAQPWLADHAVAGTVL MAB_0939|M.abscessus_ATCC_1997 EGGGGLPSG--ILGRGED-LASGD-SVYISRLSVRSQPWLSDHVIYGTVV Mvan_0269|M.vanbaalenii_PYR-1 DG--PAVSG--ILGSAKD-LASGD-TVYTSRWSVRSQPWLADHVIYGTVV Mflv_0405|M.gilvum_PYR-GCK DGRVGASAGSGILGSGKD-LASGD-SVYTSRLSVKTQPWLSDHVIYGTVV MSMEG_0408|M.smegmatis_MC2_155 DGG-TAASG--ILGSGKD-LASGD-TIYTSRLSVKSQPWLADHVIYGTVV TH_4621|M.thermoresistible__bu TRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAA : :** . : . . ****:** : .. MMAR_1762|M.marinum_M FPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVG-AAD MUL_2005|M.ulcerans_Agy99 FPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVG-TAD Mb2971c|M.bovis_AF2122/97 FPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVG-AAD Rv2946c|M.tuberculosis_H37Rv FPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVG-AAD MLBr_00135|M.leprae_Br4923 FPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVA-AAD MAV_3108|M.avium_104 FPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVVADAAG MAB_0939|M.abscessus_ATCC_1997 VPGATYAAMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQLTLHPLED Mvan_0269|M.vanbaalenii_PYR-1 VPGATYAAMALAAVGTP--ARVKDVFFYEPIILPEKASREVQLTLHPSED Mflv_0405|M.gilvum_PYR-GCK VPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTVHPSVD MSMEG_0408|M.smegmatis_MC2_155 VPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTLHPADG TH_4621|M.thermoresistible__bu LPGAAYCEMALAAAREVIDSDGVEVRDVR-FEQMLLLDEQTEVSAVASAV .*** : :.: * . :: : : :: MMAR_1762|M.marinum_M DSGNRALSVYSRGDQSED-WLLNAEGMLGVEAASSGADLS---------V MUL_2005|M.ulcerans_Agy99 DSGNRALSVYSRGDKSED-WLLNAEGMLGVEAASSGADLS---------V Mb2971c|M.bovis_AF2122/97 ESGHRAVSVYSRGDQSQG-WLLNAEGMLGVAAAETPMDLS---------V Rv2946c|M.tuberculosis_H37Rv ESGHRAVSVYSRGDQSQG-WLLNAEGMLGVAAAETPMDLS---------V MLBr_00135|M.leprae_Br4923 ESSRRAVSVYSRGDQSHGGWLLNAEGLLEVDAAEATVDLS---------L MAV_3108|M.avium_104 QPGSRSVAVYSR--VAQSEWTLHAEGVLSEAAPAPAAELS---------V MAB_0939|M.abscessus_ATCC_1997 GSGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDDAEPAPEAAEPAEPVD Mvan_0269|M.vanbaalenii_PYR-1 G-GQKFQVHSREYGERGTEWSLNAEGTVASGVDENPQ-----AEPSGPVD Mflv_0405|M.gilvum_PYR-GCK G-ESKFQVHSRPYGERGAEWALNAEGVVASGVGDSPAAAG---DLEDPVD MSMEG_0408|M.smegmatis_MC2_155 GSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSDPDAAAD---EQSDPVD TH_4621|M.thermoresistible__bu EPGTLEFAVETAKDGEHERRATAVLGAADDTEPPQAHDID---------A . * MMAR_1762|M.marinum_M WPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRR--DSELFAEVV MUL_2005|M.ulcerans_Agy99 WPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRR--DSELFAEVV Mb2971c|M.bovis_AF2122/97 WPPEGAESVDISDGYAQLAERGYAYGPAFQG-LVAIWRR--GSELFAEVV Rv2946c|M.tuberculosis_H37Rv WPPEGAESVDISDGYAQLAERGYAYGPAFQG-LVAIWRR--GSELFAEVV MLBr_00135|M.leprae_Br4923 WPPEGAESVDISDAYPQLAERGYAYGPAFQG-LVAIWRR--GSELFAEVV MAV_3108|M.avium_104 WPPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRAVWRR--GAETFAEVE MAB_0939|M.abscessus_ATCC_1997 AAIERMERMRPMELFEIFADLELAWGPTWSGSLKSLWLG--EGEAIGDVL Mvan_0269|M.vanbaalenii_PYR-1 EAIERLNRMRPQDLFETFADMELAWGPTWSGSLKSLWLG--EGEAIGDIL Mflv_0405|M.gilvum_PYR-GCK EAIERLNRMRPQELFETFADLELAWGPTWSGSLKSLWLG--EGEAIGDIL MSMEG_0408|M.smegmatis_MC2_155 EVIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLG--DGEAVGDIL TH_4621|M.thermoresistible__bu LLAEHPTRIEGDELRQWFDQRGVQFGPAFTGLTAARIPEGTVTSVLAEVG : : :** : * . . ..:: MMAR_1762|M.marinum_M AP--SGVAVDKMGMHPVVLD----AVLHALGLTAEQNPDSDETKLPFCWR MUL_2005|M.ulcerans_Agy99 AP--SGVAVDKMGMHPVVLD----AVLHALGLTAEQNPDSDETKLPFCWR Mb2971c|M.bovis_AF2122/97 APGEAGVAVDRMGMHPAVLD----AVLHALGLAVEKTQASTETRLPFCWR Rv2946c|M.tuberculosis_H37Rv APGEAGVAVDRMGMHPAVLD----AVLHALGLAVEKTQASTETRLPFCWR MLBr_00135|M.leprae_Br4923 AP--TGVVVDGMGMHPALLD----AVLHALGLAIENTQATTEMRLPFCWR MAV_3108|M.avium_104 LPEQAGVSTGRFGIHPVLLD----AALHALGVADKR----LETVLPFSWQ MAB_0939|M.abscessus_ATCC_1997 VGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYG Mvan_0269|M.vanbaalenii_PYR-1 VGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVSDLFLPLRYG Mflv_0405|M.gilvum_PYR-GCK VGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYG MSMEG_0408|M.smegmatis_MC2_155 VGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYG TH_4621|M.thermoresistible__bu LPGQIRSQQAPYGIHPALLD----ACFQSVAAHPDVQGAGSGLLLPLGVR :**.::* . : :. **: MMAR_1762|M.marinum_M GVSLHAGGAGRVRARLTMSG------PDSISVEIADAAGLPVLTVGALVT MUL_2005|M.ulcerans_Agy99 GVSLHAGGAGRVRARLTMSG------PDSISVEIADAAGLPVLTVGALVT Mb2971c|M.bovis_AF2122/97 GVSLHAGGAGRVRARFASAG------ADAISVDVCDATGLPVLTVRSLVT Rv2946c|M.tuberculosis_H37Rv GVSLHAGGAGRVRARFASAG------ADAISVDVCDATGLPVLTVRSLVT MLBr_00135|M.leprae_Br4923 GVSLHAGGAGRVRARFTSAG------ADAIAVDIADSAGLPVLTVRSLVT MAV_3108|M.avium_104 GVSLHAAGASRVRVRLAPAG------AGAVSVELADASGVPVLSVRELVT MAB_0939|M.abscessus_ATCC_1997 QVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTV Mvan_0269|M.vanbaalenii_PYR-1 QVTLRDKMPRRFYCRATWHTSELDSETQVFDLDFLDRDGRHLGGIREFTV Mflv_0405|M.gilvum_PYR-GCK QVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTV MSMEG_0408|M.smegmatis_MC2_155 QVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTV TH_4621|M.thermoresistible__bu RLQAFGPTRGARYCYARVTDAD--GSKAEADLDVLDEHGNVLLRVQGLLM : :: * * : : : MMAR_1762|M.marinum_M RAMSAAQLRAAVAAAGGGAPDQGPLDVIWSPIPLSGSG-----------T MUL_2005|M.ulcerans_Agy99 RAMSAAQLRAAVAEAGGGAPDQGPLDVIWSPIPLSGSG-----------T Mb2971c|M.bovis_AF2122/97 RPITAEQLRAAVTAAGG-ASDQGPLEVVWSPISVVSGG-----------A Rv2946c|M.tuberculosis_H37Rv RPITAEQLRAAVTAAGG-ASDQGPLEVVWSPISVVSGG-----------A MLBr_00135|M.leprae_Br4923 RAMTAEQLRTAVTAAGG-ALEQGPMDLVWSPIPLSSDG-----------H MAV_3108|M.avium_104 RAVSAEQLAAAVAVRSG---SGELLDVAWSVIEPRNSL-----------P MAB_0939|M.abscessus_ATCC_1997 KRAPREALLRGLGGDAT----RLLYTLGWHEVAVPPVAGEG-----EESA Mvan_0269|M.vanbaalenii_PYR-1 KRAPREALLRGLGGDAT----RLLYTLGWHEVPAPASG----------DA Mflv_0405|M.gilvum_PYR-GCK KRAPREALLRGLGGDAT----RLLYTLGWHEVPVPESG---------DGA MSMEG_0408|M.smegmatis_MC2_155 KRAPREALLRGLGGDAT----RLLYTLGWHEVPPPPSA-----------D TH_4621|M.thermoresistible__bu GGAAADGDDRDRVLGER------LLTIEWQRRDLPEADSAAGKWLLVSTS . : * MMAR_1762|M.marinum_M NGSAQPAVVSWADFCAGGDGGA----------------------AGDAGV MUL_2005|M.ulcerans_Agy99 NGSAQPAVVSWADFCAGGDGGA----------------------AGDAGV Mb2971c|M.bovis_AF2122/97 NGSAPPAPVSWADFCAGSDG--------------------------DASV Rv2946c|M.tuberculosis_H37Rv NGSAPPAPVSWADFCAGSDG--------------------------DASV MLBr_00135|M.leprae_Br4923 GG-GLPSVVSWADYCAGRGN--------------------------DTGV MAV_3108|M.avium_104 DNPISEGVTVWEPAAVDGAG------------------------------ MAB_0939|M.abscessus_ATCC_1997 ASIGTWLIAGFDELAAKVPGCIPLNRETDPELLGEVLVAAKERGVPFSGV Mvan_0269|M.vanbaalenii_PYR-1 ALNGNWLIAGFDELAAGVPGCIPFDRSTDPEPLGQLLAQAHERGIGFSGV Mflv_0405|M.gilvum_PYR-GCK APQGTWLIGGFDELAVSVPGCIPADR-TNPESLRQLLTDAHGRGLPFSGV MSMEG_0408|M.smegmatis_MC2_155 DAVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLGEVLSQAHARGAGFSGV TH_4621|M.thermoresistible__bu ATADVSATRLSDALKQAGAESTSMCWPQQADHADNVDRFRAGIADGVTGV MMAR_1762|M.marinum_M VVWEPNPAG------EDVVGSVYAATHAALEVLQSWFD-----GDRAGTL MUL_2005|M.ulcerans_Agy99 VVWEPNPAG------EDVVGPVYAATHAALEVLQSWFD-----GDRAGTL Mb2971c|M.bovis_AF2122/97 VVWELESAGGQASS---VVGSVYAATHTALEVLQSWLG-----ADRAATL Rv2946c|M.tuberculosis_H37Rv VVWELESAGGQASS---VVGSVYAATHTALEVLQSWLG-----ADRAATL MLBr_00135|M.leprae_Br4923 VVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFG-----QDRAGTL MAV_3108|M.avium_104 ------------------PAAVHAATHQALGVLQSRLA-----GEAGGVL MAB_0939|M.abscessus_ATCC_1997 VWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLPGGL Mvan_0269|M.vanbaalenii_PYR-1 VWRAAAPSADES--STAMAARIETEIADLLSAVHTVQN---GAVKLPGGL Mflv_0405|M.gilvum_PYR-GCK VWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQG---GEVKLPGGL MSMEG_0408|M.smegmatis_MC2_155 VWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQG---PSVKLPGGL TH_4621|M.thermoresistible__bu VVLTGPKNGNPDDAAARRGSDYVRHLVRITRELAEIDG-------DAPRL . : * MMAR_1762|M.marinum_M VVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENPG-RIVLVDADAAVEA MUL_2005|M.ulcerans_Agy99 VVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENPG-RIVLVDADAAVEA Mb2971c|M.bovis_AF2122/97 VVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPG-RIVLIDTDAAVDA Rv2946c|M.tuberculosis_H37Rv VVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENPG-RIVLIDTDAAVDA MLBr_00135|M.leprae_Br4923 VVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSG-KIVLIDTDSAVDV MAV_3108|M.avium_104 VVSTRGAVGLPGEDVADLAGAAVWGLVRSAQAEHPG-RVVLVDTDGSLDL MAB_0939|M.abscessus_ATCC_1997 WIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGSPEA Mvan_0269|M.vanbaalenii_PYR-1 WIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRCRLVDVDGSPEA Mflv_0405|M.gilvum_PYR-GCK WIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGSPQA MSMEG_0408|M.smegmatis_MC2_155 WIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGSSEA TH_4621|M.thermoresistible__bu FVVTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADDADL : *. . . : *.: *: * *.. : :* : MMAR_1762|M.marinum_M AELVA-------VGEPQLVVRSGAAHAARLAPAA------PLLAVPADES MUL_2005|M.ulcerans_Agy99 AELVA-------VGEPQLVVRSGAAHAARLAPAA------PLLAVPADES Mb2971c|M.bovis_AF2122/97 SVLAG-------VGEPQLLVRGGTVHAPRLSPAP------ALLALPAAES Rv2946c|M.tuberculosis_H37Rv SVLAG-------VGEPQLLVRGGTVHAPRLSPAP------ALLALPAAES MLBr_00135|M.leprae_Br4923 AVLAD-------LGESQLLVRCNTVHAARLSPAP------QLLALPVGES MAV_3108|M.avium_104 ATVIG-------CGEPQLVVRDGVAYRARLRPAGRR----ALLELPGPPA MAB_0939|M.abscessus_ATCC_1997 VQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRT----GHLTVPRG-S Mvan_0269|M.vanbaalenii_PYR-1 VLALAGLLAAP-VDEPELAVRQGKLLASRLLPWARS----GHLTVPRS-A Mflv_0405|M.gilvum_PYR-GCK VQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRS----GHLTVPRG-G MSMEG_0408|M.smegmatis_MC2_155 VDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARS----GHLTLPRG-G TH_4621|M.thermoresistible__bu DRVAVQLLGGG--AEDETAWRDGQWYTARLSLSPLRPEERKQAVVDCERD * : * . .** : MMAR_1762|M.marinum_M AWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAAL MUL_2005|M.ulcerans_Agy99 AWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNFRDVVAAL Mb2971c|M.bovis_AF2122/97 AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAAL Rv2946c|M.tuberculosis_H37Rv AWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNFRDVVAAL MLBr_00135|M.leprae_Br4923 MWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAAL MAV_3108|M.avium_104 VWRLAAGDAGTLEDLAVQEHP--AAELAPGQVRVRVAAAGVNFRDVLVAL MAB_0939|M.abscessus_ATCC_1997 DYVLAPTERGAIDNLRITEKE--VPAPDEGYVQVRVEAAGLNFRDVLNVL Mvan_0269|M.vanbaalenii_PYR-1 DYVLAPTERGAIDNLRLTETD--VAPPAEGYVQVRVEAAGLNFRDVLNVL Mflv_0405|M.gilvum_PYR-GCK DYVLAPTERGAIDNLRLTDSE--VPPPAEGYVQVRVEAAGLNFRDVLNVL MSMEG_0408|M.smegmatis_MC2_155 DFVLAPTERGAIDNLRLTETD--VPEPDEGYVQVRVEAAGLNFRDVLNVL TH_4621|M.thermoresistible__bu GMRLEIRTPGDLETMELAAFDR--VPPGPGQIEVAVTASSINFADVLIAF * * :: : : * :.* * * .:** **: .: MMAR_1762|M.marinum_M G---MYPGEAPPLGAEGAGVVLEVGPQVSGVAVGDSVMG--FLGGAGPLS MUL_2005|M.ulcerans_Agy99 G---MYPGAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMG--FLGGAGPLS Mb2971c|M.bovis_AF2122/97 G---MYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG--FLGGAGPLA Rv2946c|M.tuberculosis_H37Rv G---MYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMG--FLGGAGPLA MLBr_00135|M.leprae_Br4923 G---MYPGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMG--FLGGAGPLA MAV_3108|M.avium_104 G---MYPG-AAQLGAEGAGVVTEVGAGVTDVAVGDAVMG--IFGLVGSEA MAB_0939|M.abscessus_ATCC_1997 G---LYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGS-MQGAFGSRF Mvan_0269|M.vanbaalenii_PYR-1 G---LYPGDPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGF-MQGAFASRF Mflv_0405|M.gilvum_PYR-GCK G---LYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGS-MQGAFASRF MSMEG_0408|M.smegmatis_MC2_155 G---LYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGS-MQGAFASRF TH_4621|M.thermoresistible__bu GRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWSTFV * : * :* : ** * * *:. :*: * * * .. MMAR_1762|M.marinum_M VVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHAG MUL_2005|M.ulcerans_Agy99 VVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLIHAG Mb2971c|M.bovis_AF2122/97 VVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAG Rv2946c|M.tuberculosis_H37Rv VVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLIHAG MLBr_00135|M.leprae_Br4923 VVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAG MAV_3108|M.avium_104 AVDRRLVTRVPPGWSMAQAAGIPVVFLTAYYGLSVLAGLRAGQRVLVHAA MAB_0939|M.abscessus_ATCC_1997 NVPAQFLAPIPDGISGVEAATIPAAALTVRLSFD-WAQLKPGDKVLIHAA Mvan_0269|M.vanbaalenii_PYR-1 NVPAQLLAPIPDGIGAVDAATIPAAALTARLAFD-WAQLKPGDRVLIHAA Mflv_0405|M.gilvum_PYR-GCK NVPGQFLAPIPDGVSAVEAATIPAAALTVRLSFD-WAQVKSGDKVLIHAA MSMEG_0408|M.smegmatis_MC2_155 NVPAQFLAPIPDGIGAVEAATIPAAALTVRLAFD-WAQLKPGDKVLIHAA TH_4621|M.thermoresistible__bu TCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLIHSA : . :* * :** :... *. .: * : .*: **:*:. MMAR_1762|M.marinum_M TGGVGMAAVQLARHWGVEIFVTASR-GKWDTLRAMGFDDDHIGDSRTLDF MUL_2005|M.ulcerans_Agy99 TGGVGMAAVQLARHWGVEIFVTASR-GKWDTLRAMGFDDDHIGDSRTLDF Mb2971c|M.bovis_AF2122/97 TGGVGMAAVQLARQWGVEVFVTASR-GKWDTLRAMGFDDDHIGDSRTCEF Rv2946c|M.tuberculosis_H37Rv TGGVGMAAVQLARQWGVEVFVTASR-GKWDTLRAMGFDDDHIGDSRTCEF MLBr_00135|M.leprae_Br4923 TGGVGMAAVQFARHWGVEIFVTASR-GKWDTLRDMGFDDDHIGDSRTLEF MAV_3108|M.avium_104 TGGVGMAAVQLARHWGAEVFATASR-GKWDTLRAMGFDDAHIADSRTLDF MAB_0939|M.abscessus_ATCC_1997 SGGVGLAAIQMAQQFGAEVFATAST-FKRATLRKLGVK--YVYDSRTTDF Mvan_0269|M.vanbaalenii_PYR-1 SGGVGLAAIQMAQQHGAVVFATAST-YKRATLRKLGVD--HVYDSRTTEF Mflv_0405|M.gilvum_PYR-GCK SGGVGLAAVQMAQQCGAEVYATAST-FKRATLRKLGVK--HVYDSRTTDF MSMEG_0408|M.smegmatis_MC2_155 SGGVGLAAIQMAQQSGAEVFATAST-FKRSTLRRLGVK--YVYDSRTTDF TH_4621|M.thermoresistible__bu TGGVGLAAIAIARSVGAQIYATAGSPARRDLLRDMGIE--HVYDSRSTAF :****:**: :*: *. ::.**. : ** :*.. :: ***: * MMAR_1762|M.marinum_M EEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDA MUL_2005|M.ulcerans_Agy99 EEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDA Mb2971c|M.bovis_AF2122/97 EEKFLAVTEGRGVDVVLDSLAGE-FVDASLRLLVRGGRFLEMGKTDIRDA Rv2946c|M.tuberculosis_H37Rv EEKFLAVTEGRGVDVVLDSLAGE-FVDASLRLLVRGGRFLEMGKTDIRDA MLBr_00135|M.leprae_Br4923 EEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDA MAV_3108|M.avium_104 EQKFGAAPG--GMDVVLNSLAGE-FNDASLRLLGPGGRFIEMGKTDLRDP MAB_0939|M.abscessus_ATCC_1997 ADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTT Mvan_0269|M.vanbaalenii_PYR-1 ADQILADTDGEGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAKRDIWTP Mflv_0405|M.gilvum_PYR-GCK AEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTV MSMEG_0408|M.smegmatis_MC2_155 ADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSH TH_4621|M.thermoresistible__bu ADEIRRDTDGYGVDVVLNSLPGA-AQRAGLELLSFGGRFIEIGKRDIYGD ::: . *:****:**.. * :. *** *:.* *: MMAR_1762|M.marinum_M DKIAAN--YPGVWYRAFDLSEAG---PVRMQEMLAEVRELFDTA------ MUL_2005|M.ulcerans_Agy99 DKIAAN--YPGVWYRAFDLSEAG---PVRMQEMLAEVRELFDTA------ Mb2971c|M.bovis_AF2122/97 QEIAAN--YPGVQYRAFDLSEAG---PARMQEMLAEVRELFDTR------ Rv2946c|M.tuberculosis_H37Rv QEIAAN--YPGVQYRAFDLSEAG---PARMQEMLAEVRELFDTR------ MLBr_00135|M.leprae_Br4923 QEIAAN--YPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQ------ MAV_3108|M.avium_104 DVVARA--HPGVRYRAFDLMEAG---PDRIAAMLAEVMELFAAG------ MAB_0939|M.abscessus_ATCC_1997 EQMAQS--RPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKG------ Mvan_0269|M.vanbaalenii_PYR-1 EQMAAA--RPDIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADGSSRA Mflv_0405|M.gilvum_PYR-GCK EQMAAA--RPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG------ MSMEG_0408|M.smegmatis_MC2_155 EQMAEA--RPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARG------ TH_4621|M.thermoresistible__bu TRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYRLTADG------ :. .: :. . * * :: :* * MMAR_1762|M.marinum_M VLHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSA-----------L MUL_2005|M.ulcerans_Agy99 VLHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSA-----------L Mb2971c|M.bovis_AF2122/97 ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSA-----------L Rv2946c|M.tuberculosis_H37Rv ELHRLPVTTWDVRCAPAAFRFMSQARHIGKVVLTMPSA-----------L MLBr_00135|M.leprae_Br4923 VLHRLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSA-----------L MAV_3108|M.avium_104 ALTPLPVKAFDARCAADAYRFVSAARHIGKVVLTMPDG-----------P MAB_0939|M.abscessus_ATCC_1997 EWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNP-----------L Mvan_0269|M.vanbaalenii_PYR-1 EWVPLPAEIYPLTEARAAFRRMQQARHVGKIVLQMPKP-----------L Mflv_0405|M.gilvum_PYR-GCK AWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNP-----------L MSMEG_0408|M.smegmatis_MC2_155 EWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKP-----------L TH_4621|M.thermoresistible__bu VLPMPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVPHTGRADVVVPPEQA : * * * :. *.*:**:* :* MMAR_1762|M.marinum_M ADGLADATVLITGATGAVGAVLARHMLDAYGVRHLVLASRRGDRAEGAAE MUL_2005|M.ulcerans_Agy99 ADGLADATVLITGATGAVGAVLARHMLDGYGVRHLVLASRRGDRAEGAAE Mb2971c|M.bovis_AF2122/97 ADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAE Rv2946c|M.tuberculosis_H37Rv ADRLADGTVVITGATGAVGGVLARHLVGAYGVRHLVLASRRGDRAEGAAE MLBr_00135|M.leprae_Br4923 ADGLAEGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGAVE MAV_3108|M.avium_104 AG-LSGGTALITGATGMAGAALARHLVARHRVPHLMLVGRRGEAAPGMAE MAB_0939|M.abscessus_ATCC_1997 AP-RPDRTYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRV Mvan_0269|M.vanbaalenii_PYR-1 QP-RADRSYLITGGLGAIG-LHTAAYLAQLGAGDLVLTSRRAPDADARRA Mflv_0405|M.gilvum_PYR-GCK QP-QPDRSYLITGGLGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQA MSMEG_0408|M.smegmatis_MC2_155 QP-QQDRSYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRA TH_4621|M.thermoresistible__bu SPFRSDGAYIVTGGMGGLG-LYLAGEMAAAGAGCIVLNGRSAPSGEALRT : ::**. * * : . ::* .* . MMAR_1762|M.marinum_M LAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGVLD MUL_2005|M.ulcerans_Agy99 LAAELSEAGANVQVVACDVADRDAVEAMLARLSGEYPPVRGVIHAAGVLD Mb2971c|M.bovis_AF2122/97 LAADLTEAGAKGQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLD Rv2946c|M.tuberculosis_H37Rv LAADLTEAGAKVQVVACDVADRAAVAGLFAQLSREYPPVRGVIHAAGVLD MLBr_00135|M.leprae_Br4923 LAAELVGAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLD MAV_3108|M.avium_104 LAAELRGAGASVSVLSCDVGDRDAVAAMLAQVPARYP-LRSVFHAAGVLD MAB_0939|M.abscessus_ATCC_1997 IGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLD Mvan_0269|M.vanbaalenii_PYR-1 IEEITERYKCRVHTFCADVGDESQVAELLARIRAELPPLAGVAHLAGVLD Mflv_0405|M.gilvum_PYR-GCK IADIADRTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLD MSMEG_0408|M.smegmatis_MC2_155 IDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLD TH_4621|M.thermoresistible__bu IEQLRAAGTEVIVECGXXX---------------RGQPVEVAVPTELRHA : . : MMAR_1762|M.marinum_M DAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGS MUL_2005|M.ulcerans_Agy99 DAVISSLTPERIDTVLRAKVDAAWNLHEATLDLDLSMFVLCSSIAATVGS Mb2971c|M.bovis_AF2122/97 DAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFVLCSSIAATVGS Rv2946c|M.tuberculosis_H37Rv DAVITSLTPDRIDTVLRAKVDAAWNLHQATSDLDLSMFALCSSIAATVGS MLBr_00135|M.leprae_Br4923 DGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGS MAV_3108|M.avium_104 DAVIASLTPARIDTVLRAKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGA MAB_0939|M.abscessus_ATCC_1997 DALLGQQSVERFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGS Mvan_0269|M.vanbaalenii_PYR-1 DALLSQQSLERFRTTLAPKAFGACHLDRLTAGDDLDFFIMSSSVSSLFGS Mflv_0405|M.gilvum_PYR-GCK DALLSQQSVERFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGS MSMEG_0408|M.smegmatis_MC2_155 DALLSAQNPERFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGS TH_4621|M.thermoresistible__bu DEHPDRRGAQLCDEFARGEQGAQRNQHRTDAGEGQRDAHPPGAVGHDQPD * : . .. . .::. MMAR_1762|M.marinum_M PGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDL MUL_2005|M.ulcerans_Agy99 PGQGNYSAANSFLDGLAAHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDL Mb2971c|M.bovis_AF2122/97 PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDL Rv2946c|M.tuberculosis_H37Rv PGQGNYSAANAFLDGLAAHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDL MLBr_00135|M.leprae_Br4923 PGQGNYSAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDL MAV_3108|M.avium_104 PGQGNYAAANSFLDALAIHRHAHGLPALSVAWGMWEEPSAMTAHLEERDK MAB_0939|M.abscessus_ATCC_1997 PGQSNYATANALLDGLIAQRRAQGLPATGINFGPWGQ-GGMAS--SEAAT Mvan_0269|M.vanbaalenii_PYR-1 PGQANYATANALLDGLTAHRRARGLPATGVNFGPWAQ-GGMAS--SEAAT Mflv_0405|M.gilvum_PYR-GCK PGQSNYATANAFLDGLVAQRRAQGLPATGVNFGPWAR-GGMAS--SEAAA MSMEG_0408|M.smegmatis_MC2_155 PGQANYATANAMLDGLVAKRRAQGLVATGINFGPWGQ-GGMAS--SEAAT TH_4621|M.thermoresistible__bu PG---------ALSDTGLDERGGQFPGVGVQIPVADPGVGIDHRGAVRVD ** *. .:. : . .: .: MMAR_1762|M.marinum_M ARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGGL MUL_2005|M.ulcerans_Agy99 ARMSRSGLAPMNPEQAVGLLDAVLAINHPLMVATLLDRPALEARAQAGGL Mb2971c|M.bovis_AF2122/97 ARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGAL Rv2946c|M.tuberculosis_H37Rv ARMSRSGLAPMSPAEAVELFDAALAIDHPLAVATLLDRAALDARAQAGAL MLBr_00135|M.leprae_Br4923 ARISRSGLAPMNPAQALELFDAALVIDHPFMVTALLDRAALDAQAQAGAL MAV_3108|M.avium_104 ARMSRAGLSALSTRQALDLLDDALLGEQPLVVGTRLDRAALAQHRAA--L MAB_0939|M.abscessus_ATCC_1997 ANISAQGLIPLDPSAALAALAEVVANG-TGQATILKANWQRAAKVLGSSR Mvan_0269|M.vanbaalenii_PYR-1 ANIGAQGLVPLEPSAALGALAEVLANG-TGQAAVLKANWQRAAKVLGSSR Mflv_0405|M.gilvum_PYR-GCK ANISAQGLIPLEPSAALTAMAEVVANG-TAQATVLKANWQRAAKVLGSSR MSMEG_0408|M.smegmatis_MC2_155 ANITAQGLIPLDPSAALHALAEVIANG-SGQATVLKANWQRAAKVLGSAR TH_4621|M.thermoresistible__bu SGVP----------AQQGVDGEVVRHRTLSSVRSGRSSRWTAPGSRCGSG : : .: . MMAR_1762|M.marinum_M PPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGLVC MUL_2005|M.ulcerans_Agy99 PPLFAGVVRRPRRRQIEDTGDAAQSKSALAERLNGLSAGERQDALVGLVC Mb2971c|M.bovis_AF2122/97 PALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVC Rv2946c|M.tuberculosis_H37Rv PALFSGLARRPRRRQIDDTGDATSSKSALAQRLHGLAADEQLELLVGLVC MLBr_00135|M.leprae_Br4923 PPLFSRLVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVC MAV_3108|M.avium_104 PPLLSELAGRPARRMLEHT--DMVSLTGLRARLAGMNPEQRQAELVELVC MAB_0939|M.abscessus_ATCC_1997 PPILDLVLPSAVG--------EVTGDSELLKQLMEIPVPQRAGFVTEFLQ Mvan_0269|M.vanbaalenii_PYR-1 PPILDLVLPRPEG--------EVAGDSELLRQLQEIPVAQRAGFVTEFLQ Mflv_0405|M.gilvum_PYR-GCK PPILDLVLPSAVG--------EITGDSELLKQLQEIPVPQRAGFVTEFLQ MSMEG_0408|M.smegmatis_MC2_155 PPILDLVLPSAAG--------EATGDSELLKQLMEIPIPQRAGFVTEFLQ TH_4621|M.thermoresistible__bu RRYGGESCRRTTG--------PAAGAAARRGRTRRRRRPRRPPPPPDRVR . . : .: : MMAR_1762|M.marinum_M LQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNRLKSATG--LTLPP MUL_2005|M.ulcerans_Agy99 LQAAAVLGRPSPEDIDPEAGFQDLGFDSLTAVELRNRFKSATG--LTLPP Mb2971c|M.bovis_AF2122/97 LQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATG--LTLPP Rv2946c|M.tuberculosis_H37Rv LQAAAVLGRPSAEDVDPDTEFGDLGFDSLTAVELRNRLKTATG--LTLPP MLBr_00135|M.leprae_Br4923 LQAAAVLGRPSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLPP MAV_3108|M.avium_104 GNAAAVLG-HSTADVDPGDAFSDLGFDSLTAVELRNRLKIATG--LTLSP MAB_0939|M.abscessus_ATCC_1997 REVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGKFTINA Mvan_0269|M.vanbaalenii_PYR-1 REVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINA Mflv_0405|M.gilvum_PYR-GCK KEVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINA MSMEG_0408|M.smegmatis_MC2_155 REVQNFLRLASPP--AASSRFLDLGTDSLMAIELRNRLHSQFGGKFTINA TH_4621|M.thermoresistible__bu HRAGPAHGPVRR-------------------------------------- .. MMAR_1762|M.marinum_M TVIFDHPTPTAIAEYVGRQIPDSQATQAEE--EKLPESDGEMVSVTA--- MUL_2005|M.ulcerans_Agy99 TVIFDHPTPTAIAEYVGRQIPDSQATQAEE--EKLPESDGEMVSVTA--- Mb2971c|M.bovis_AF2122/97 TVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA--- Rv2946c|M.tuberculosis_H37Rv TVIFDHPTPTAVAEYVAQQMSGSRPTESGDPTSQVVEPAAAEVSVHA--- MLBr_00135|M.leprae_Br4923 TVIFDHPTPTAVAEYVAQQMLKSRPAESGDETSQAVEPKVEEVSVHA--- MAV_3108|M.avium_104 TVIFDHPTPAALAEHLGGQLTSAGPTPAAPAETAAPPDRSSRIDEVVSEL MAB_0939|M.abscessus_ATCC_1997 TAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAASD Mvan_0269|M.vanbaalenii_PYR-1 TAVFDYPTIGGLAEYLVGQLPDSDAAAGETPATETSPIDHNHPDREADSP Mflv_0405|M.gilvum_PYR-GCK TAVFDYPTIGGLAEYLVAQLPD-----AETPQAAPQSESEPGPDVTE--- MSMEG_0408|M.smegmatis_MC2_155 TAVFDYPTIGGLAEYLVGQLPD-----AEAPETA---------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- Rv2946c|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MAV_3108|M.avium_104 QTLLTQPGLSPGDRAQLVTRLQSLLSTPPQPSGHPEFPEDAFDDDIATAT MAB_0939|M.abscessus_ATCC_1997 AVSELKE------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 G------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MMAR_1762|M.marinum_M -------------- MUL_2005|M.ulcerans_Agy99 -------------- Mb2971c|M.bovis_AF2122/97 -------------- Rv2946c|M.tuberculosis_H37Rv -------------- MLBr_00135|M.leprae_Br4923 -------------- MAV_3108|M.avium_104 DSQLFAILDDEAGP MAB_0939|M.abscessus_ATCC_1997 -------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------- Mflv_0405|M.gilvum_PYR-GCK -------------- MSMEG_0408|M.smegmatis_MC2_155 -------------- TH_4621|M.thermoresistible__bu --------------