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MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMGCRYPGGVDSPETLWELVAHGRDAVSEF PADRGWDVAGLFDPDPDAVGKSYTRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAG IDPITLRGSQTGVFAGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRVAYVLGLQGPAVSVDTACSSSL VALHLAVQSLRLGECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLAR LADARRLGHPVLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEGHGTGTTLGDP IEAQAILATYGQRPADRPLWLGSIKSNIGHTSAAAGVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAG AVSLLTEPRPWHVPGRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDPVAVPWVLSARSAQALTN QARRLLAWVGADENVRPLDVGWSLVNTRSLFDHRAVVVGADRTQLMEGLTGLAAGVPGADVVAGRAQTVG KTAFVFPGQGAQWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAPGAPGLDRVDVVQPALW AVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQP QAEKLASQWGDRLNIAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIA ALRGIEPRTSTVAFFSTVTGELMDTAGVNAEYWYRSIRQPVQFERAVRNAFDGGYRVFVESSPHPVLIAG IEETLVDCDRGATGEPIVIPTLGRDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQ RFWLDGLGAVGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVGPVVLFPGTGFV ELALRAGDEVGCSVLQELTLQAPLVLPADGVRVQVVVGGVEQSGTRNVWVYSAAGQADSSPGWTLHAQGV LGVGSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRGAEVFADVTLPEGVPIRG FGIHPAVLDAALHAWGIVEGEQQTMLPFSWQGVCLHASGAARVRVRLAPVGRGAVSVELADPQGLPVLSV RQLMVRPVSAAALSRSTAGDRGLLEMIWTPVPLEGGDIGDDAVVWELPPHAGAQAGGDVLAAVYRGVHEV LEVLQSWLASDATGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGRVVLVDTDGSVAVEDAVG FGARSGEPQLVVRRGRVYAARLAPVAAGLTLPSASAGGWRLVAGGGGTLADVVVAPVAPVELATGQVRVA VGAVGVNFRDVLVALGMYPGGGELGVDGAGVVVEVGPGVTGLAVGDRVMGLLGLVGSEAVVDARLVTMVP AGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTGGVGMAAVSLARYWGAEVFVTASRAKWDTL RAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLRLLPSGGRFIELGKTDIRDGQTV AERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLT IPDGPGGQSGLAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRAAEVAALLREGGAQVA VVSCDVADRDALAALLAGLDPRYPLKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMD LSAFVVFSSMAGIVGTPAQGNYAAANAFLDGLVAYRRSRGLAGLSVAWGLWEQASAMTRHLGERDRARMT QAGLAPLTTEQALGFLDTALQADRAVVVAARLDRAALAGAGAALPALFSQLAAGPTRRRIDAADTAVSMS GLVSRLHALTPERRQRELTDLVISNAAAVLGRSSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLS PTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVDDITRELVVLLDQPDLSANVKAHLRTRLQTMLTS LTTEDDDIAAATESQLFAILDEELGS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv1661 | pks7 | - | 100% (2126) | Probable polyketide synthase pks7 |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 61.04% (2056) | polyketide synthase pks12 |
M. tuberculosis H37Rv | Rv1662 | pks8 | 0.0 | 61.85% (1612) | polyketide synthase pks8 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1689 | pks7 | 0.0 | 99.91% (2126) | polyketide synthase pks7 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 36.98% (2155) | beta-ketoacyl synthase |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 56.31% (2117) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 36.78% (2156) | polyketide synthase |
M. marinum M | MMAR_2471 | pks7 | 0.0 | 70.49% (2138) | polyketide synthase Pks7 |
M. avium 104 | MAV_3109 | - | 0.0 | 71.30% (2143) | RifB protein |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 37.34% (2145) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 36.56% (1841) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 60.98% (2068) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 37.29% (2156) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK -----------------------------MGSAAHQGE-SAHRFAIVGYA MAB_0939|M.abscessus_ATCC_1997 -----------------------------MDSAENPIE-STPRFAIIGYA MSMEG_0408|M.smegmatis_MC2_155 -----------------------------MVSAEHPIE-PTPSFAIIGYA Mvan_1003|M.vanbaalenii_PYR-1 ---------------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYA Rv1661|M.tuberculosis_H37Rv -------MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMG Mb1689|M.bovis_AF2122/97 -------MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMG MMAR_2471|M.marinum_M -------MDSTPDELITALRKTLKENERLKRENRDHLAQATEPVAVVGMG MAV_3109|M.avium_104 -------MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMG MUL_2266|M.ulcerans_Agy99 -------MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMS MLBr_00135|M.leprae_Br4923 MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIG TH_4621|M.thermoresistible__bu --------------------------------VNIVGDTPVNAVAVIGMA . *::* . Mflv_0405|M.gilvum_PYR-GCK GRFPG-ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVV MAB_0939|M.abscessus_ATCC_1997 ARFPG-AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVV MSMEG_0408|M.smegmatis_MC2_155 ARFPG-AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVV Mvan_1003|M.vanbaalenii_PYR-1 LRFPG-AADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMV Rv1661|M.tuberculosis_H37Rv CRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSY Mb1689|M.bovis_AF2122/97 CRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSY MMAR_2471|M.marinum_M CRYPGGIETPEGLWEMVAAGRDVVSDFPTDRGWDGASLFDPDPDAVGKSY MAV_3109|M.avium_104 CRYPGGVDSPEALWEMVVEGRDVVSEFPADRGWDLAGLFDADPDAVGKSY MUL_2266|M.ulcerans_Agy99 CRFPGGVDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSY MLBr_00135|M.leprae_Br4923 CRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY TH_4621|M.thermoresistible__bu CRLPGGIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVPGRTV * ** .: * : : :::.* ** ** **.:* . : Mflv_0405|M.gilvum_PYR-GCK TRRAGFVDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAP MAB_0939|M.abscessus_ATCC_1997 TRRAGFVEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAP MSMEG_0408|M.smegmatis_MC2_155 TRRAGFVDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAP Mvan_1003|M.vanbaalenii_PYR-1 TRRAGFVEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAP Rv1661|M.tuberculosis_H37Rv TRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP Mb1689|M.bovis_AF2122/97 TRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP MMAR_2471|M.marinum_M TRSGGFLTDVAGFDAEFFGIAPSEVMAMDPQQRLLLEVSWEALERTGIDP MAV_3109|M.avium_104 CRCGGFLTGVGDFDAAFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP MUL_2266|M.ulcerans_Agy99 ASTGGFVDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDP MLBr_00135|M.leprae_Br4923 TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDP TH_4621|M.thermoresistible__bu SRWGAFLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTP ..*: .. .**. ***:: *. :***:*:::* :*.*:* :* * Mflv_0405|M.gilvum_PYR-GCK SELANTNTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRIS MAB_0939|M.abscessus_ATCC_1997 TDLAETNSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRIS MSMEG_0408|M.smegmatis_MC2_155 TSLANSNTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRIS Mvan_1003|M.vanbaalenii_PYR-1 SALAGTRTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRIS Rv1661|M.tuberculosis_H37Rv ITLRGSQTGVFAGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA Mb1689|M.bovis_AF2122/97 ITLRGSQTGVFAGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA MMAR_2471|M.marinum_M TTLRGSATGVFVGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA MAV_3109|M.avium_104 ATLRGSATGVFAGIFHGSYGGQG---RVPGNLERYGLRGSTLSVASGRVA MUL_2266|M.ulcerans_Agy99 TGLRGSATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVA MLBr_00135|M.leprae_Br4923 LSLRGSATGVFTGIFAPSYGS-----RDTGGLQGYGLTGTAVSVASGRVS TH_4621|M.thermoresistible__bu ADVEGSSTGVFVGLSHDDYALLTS--DAGALEEAYGFTGSAFSMASGRIA : : :*** *: .* : * * : : * **:: Mflv_0405|M.gilvum_PYR-GCK YRLGLQGPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPA MAB_0939|M.abscessus_ATCC_1997 YRLGLQGPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPA MSMEG_0408|M.smegmatis_MC2_155 YRLGLQGPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPA Mvan_1003|M.vanbaalenii_PYR-1 YRLGLQGPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPA Rv1661|M.tuberculosis_H37Rv YVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Mb1689|M.bovis_AF2122/97 YVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA MMAR_2471|M.marinum_M YVLGLEGPAVSVDTACSSSLVALHLAVQSLRSRECDLALVGGVTVMATPA MAV_3109|M.avium_104 YALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA MUL_2266|M.ulcerans_Agy99 YVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPT MLBr_00135|M.leprae_Br4923 YVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPS TH_4621|M.thermoresistible__bu YRLGVHGPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPR * **:.**:*:*********:*:* * :*: *.*:**.**. * * Mflv_0405|M.gilvum_PYR-GCK TMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDR MAB_0939|M.abscessus_ATCC_1997 TMITFSHAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDR MSMEG_0408|M.smegmatis_MC2_155 TMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDR Mvan_1003|M.vanbaalenii_PYR-1 TMINFSRARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDR Rv1661|M.tuberculosis_H37Rv MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHP Mb1689|M.bovis_AF2122/97 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHP MMAR_2471|M.marinum_M MFIEFSRQRALSADGRCKAYAGAADGTAFSEGAGALVLERLTDAQRLGHP MAV_3109|M.avium_104 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHS MUL_2266|M.ulcerans_Agy99 VFVEFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHP MLBr_00135|M.leprae_Br4923 IFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHT TH_4621|M.thermoresistible__bu KYTSASGLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDR * *:. *:.::: :*** .** ::: ** ** * .. Mflv_0405|M.gilvum_PYR-GCK IRAVIRGSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEA MAB_0939|M.abscessus_ATCC_1997 IRAVIRGSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEA MSMEG_0408|M.smegmatis_MC2_155 IRAVIRGSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEA Mvan_1003|M.vanbaalenii_PYR-1 IRAVIRGSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEA Rv1661|M.tuberculosis_H37Rv VLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG Mb1689|M.bovis_AF2122/97 VLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG MMAR_2471|M.marinum_M VLAVVRGSAVNQDGASNGLATPNGPSQQRVIRAALASARLGVADVDVVEG MAV_3109|M.avium_104 VLAVLRGSAVNQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEG MUL_2266|M.ulcerans_Agy99 VLALVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEG MLBr_00135|M.leprae_Br4923 VLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEA TH_4621|M.thermoresistible__bu ILAVVRGTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEA : *::**:* **** : .::.*. :* * ** * : . *. :*. Mflv_0405|M.gilvum_PYR-GCK HGTGTSLGDPIEAQAAGAALGPG----REPQRPLLIGSAKTNIGHLEAAA MAB_0939|M.abscessus_ATCC_1997 HGTGTSLGDPIEAQAAGAAYGIG----RETNDPLLIGSAKTNIGHLEAAA MSMEG_0408|M.smegmatis_MC2_155 HGTGTSLGDPIEAQAAGEVLGAG----RAPEEPLLIGSAKTNIGHLEAAA Mvan_1003|M.vanbaalenii_PYR-1 HGTGTPLGDPIEVQAAGAVLGVG----REPDRPLLIGSVKTNIGHLEAAS Rv1661|M.tuberculosis_H37Rv HGTGTTLGDPIEAQAILATYGQ-----RPADRPLWLGSIKSNIGHTSAAA Mb1689|M.bovis_AF2122/97 HGTGTTLGDPIEAQAILATYGQ-----RPADRPLWLGSIKSNIGHTSAAA MMAR_2471|M.marinum_M HGTGTTLGDPIEAQAILATYGQDR--TGPGKEPLWLGSIKSNMGHTSAAA MAV_3109|M.avium_104 HGTGTMLGDPIEAQALLATYGQD----RPVDEPLWLGSIKSNMGHTSAAA MUL_2266|M.ulcerans_Agy99 HGTGTTLGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAA MLBr_00135|M.leprae_Br4923 HGTATTLGDPIEAQALLATYGQG----RPADQPLWVGSIKSNMGHTQAAA TH_4621|M.thermoresistible__bu HGTGTPVGDPIEYNSLTQVYGKTG--------PCALTSVKTNFGHAESAA ***.* :***** :: . * . : * *:*:** .:*: Mflv_0405|M.gilvum_PYR-GCK GIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQ MAB_0939|M.abscessus_ATCC_1997 GIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR-- MSMEG_0408|M.smegmatis_MC2_155 GIAGVIKVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR-- Mvan_1003|M.vanbaalenii_PYR-1 GIAGLLKVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR-- Rv1661|M.tuberculosis_H37Rv GVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP- Mb1689|M.bovis_AF2122/97 GVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP- MMAR_2471|M.marinum_M GVAGVIKMTLAMQHGVLPQTLHVDVPTPHVDWSAGSVSLLTEARPWPET- MAV_3109|M.avium_104 GAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSAGAVSLLTEARPWPAR- MUL_2266|M.ulcerans_Agy99 GVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAES MLBr_00135|M.leprae_Br4923 GVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVE- TH_4621|M.thermoresistible__bu GALGMMKAILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVR- * *::* ::.: :* :. . .: : : . * Mflv_0405|M.gilvum_PYR-GCK RGGRPRIAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLP MAB_0939|M.abscessus_ATCC_1997 -NGRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILP MSMEG_0408|M.smegmatis_MC2_155 -NGKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLP Mvan_1003|M.vanbaalenii_PYR-1 -SGRSRVAGISSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLP Rv1661|M.tuberculosis_H37Rv --GRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDP---VAVPWV Mb1689|M.bovis_AF2122/97 --GRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDP---VAVPWV MMAR_2471|M.marinum_M --GRARRAGISSFGISGTNAHVILEQAPAAEEVAAQHRTD-----LTPWI MAV_3109|M.avium_104 --DRPRRAGVSSFGISGTNAHVIVEQY---EPETVAPQGGD---VVVPWV MUL_2266|M.ulcerans_Agy99 AGDRVRRAGVSSFGISGTNAHVIVEAAPRVEVGGSS-GGAV---PVVPWV MLBr_00135|M.leprae_Br4923 --GRPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTADQQRL-SVVPWV TH_4621|M.thermoresistible__bu -EGCPRRAAVSSYGMSGTNVHAVLEQAPEPVQRPEESADTD-AAGPLVFA . * *.:**:*::***.*.::* Mflv_0405|M.gilvum_PYR-GCK LSARTPAALMAVADRYRDWLVAN-PDATLADLCFTAGTARSHLEHRAALV MAB_0939|M.abscessus_ATCC_1997 LSARTPAALAQLADKYRAWLNAH-PEAALADLCFTAGVGRAHLEHRAALV MSMEG_0408|M.smegmatis_MC2_155 LSARTPEALVRLAGEYRDWLRAH-PQARLADVSHTAGTARAHLEQRAALV Mvan_1003|M.vanbaalenii_PYR-1 LSARTPDALAATAHRLRTWLAAN-PDASWPDLCFTAAVGRSHLRHRAALV Rv1661|M.tuberculosis_H37Rv LSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSLFDHRAVVV Mb1689|M.bovis_AF2122/97 LSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSLFDHRAVVV MMAR_2471|M.marinum_M LAARSAPALVNQARRLAQWVSDR-PDLDVADVGWSLATTRSVFEHRAVVV MAV_3109|M.avium_104 LSARSAEALTNQAARLLARVKAD-PGVRVLDVGWSLVSTRSRFEHRAVIV MUL_2266|M.ulcerans_Agy99 VSAKSGSALGAQAARLAAHVRSH-DELDVADVGWSLAG-RSTFEHRAVVL MLBr_00135|M.leprae_Br4923 VSGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSVFEHRAVVV TH_4621|M.thermoresistible__bu LSSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVI ::. : * * . : *: : *: *:.:: Mflv_0405|M.gilvum_PYR-GCK VNTREAALDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMS MAB_0939|M.abscessus_ATCC_1997 VNTREAAVELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGSQYPGMA MSMEG_0408|M.smegmatis_MC2_155 VNSRESAIELLGALADDRPA-PGLVRGESHEAPKTAWLFTGQGSQYPGMA Mvan_1003|M.vanbaalenii_PYR-1 VDSRSSVEELLGALAEDRPG-PGLARGECGDPPKTAWLFTGQGSQYPGMG Rv1661|M.tuberculosis_H37Rv GADRTQLMEGLTGLAAGVPG-ADVVAGRAQTVGKTAFVFPGQGAQWLGMG Mb1689|M.bovis_AF2122/97 GADRTQLMEGLTGLAAGVPG-ADVVAGRAQTVGKTAFVFPGQGAQWLGMG MMAR_2471|M.marinum_M GADRTQLIQGLAGFVDGEPR-AGVVVGRARPVGKTVFVFPGQGSQWVGMG MAV_3109|M.avium_104 GADGAQLLRRLADLAGGQPG-AGVVTGRAQPVGKTVFVFPGQGSQWPGMG MUL_2266|M.ulcerans_Agy99 GADRDGLLAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMG MLBr_00135|M.leprae_Br4923 GESREQLIAGLAGLAVGESG-AGVAIGQAAPLGKTVVVFPGQGAQRIGMG TH_4621|M.thermoresistible__bu ADGVEALTAGLREVADGDAP---YQPAVGMDDKAPVWVFSGQGSQWAGMG * .. . . .. :*.***:* **. Mflv_0405|M.gilvum_PYR-GCK RELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRH MAB_0939|M.abscessus_ATCC_1997 RELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQ MSMEG_0408|M.smegmatis_MC2_155 RELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRH Mvan_1003|M.vanbaalenii_PYR-1 RELFDTEPVYREVMTRCAEAVADVLERPLLDVVFDAD------GGEALRH Rv1661|M.tuberculosis_H37Rv AQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAP------GAPGLDR Mb1689|M.bovis_AF2122/97 AQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAP------GAPGLDR MMAR_2471|M.marinum_M VDLLDTSTVFADQMHRCEKALAEYVSWSLLDVVRAVP------GAPGLNR MAV_3109|M.avium_104 AQLLDRSTVFAEHMHRCARALAEHVDWSLIDVIRGAP------GAPGLDR MUL_2266|M.ulcerans_Agy99 IELLDTAPVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDR MLBr_00135|M.leprae_Br4923 RELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD------AG-LLDS TH_4621|M.thermoresistible__bu AELLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET---------VTG :* :: . . .: :.: : Mflv_0405|M.gilvum_PYR-GCK TSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRD MAB_0939|M.abscessus_ATCC_1997 TSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLED MSMEG_0408|M.smegmatis_MC2_155 TTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVED Mvan_1003|M.vanbaalenii_PYR-1 TSYAQPALYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLED Rv1661|M.tuberculosis_H37Rv VDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRD Mb1689|M.bovis_AF2122/97 VDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLWD MMAR_2471|M.marinum_M VDVVQPVLWAIMVSLAELWRSAGVLPDAVIGHSQGEIAAAYVAGALSLED MAV_3109|M.avium_104 VDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAACVAGALSLHD MUL_2266|M.ulcerans_Agy99 IDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRD MLBr_00135|M.leprae_Br4923 TEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPAD TH_4621|M.thermoresistible__bu IDRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLED .**.*:*: :.* : *. *. *:*** *: :** ** .: * Mflv_0405|M.gilvum_PYR-GCK GARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEY--PALSVAAYNG MAB_0939|M.abscessus_ATCC_1997 GARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEF--PSLSVAAYNG MSMEG_0408|M.smegmatis_MC2_155 GARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEY--PSLSVAAYNG Mvan_1003|M.vanbaalenii_PYR-1 GAVLLAERGRLFGSLPEGGRMAAVFAPADRVESCTVDS--PLLSVAAYNG Rv1661|M.tuberculosis_H37Rv AAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWG-DRLNIAAVNG Mb1689|M.bovis_AF2122/97 AAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWG-DRLNIAAVNG MMAR_2471|M.marinum_M AARVVARRSQLLVQLSGAGGMVSLACGLERARQLVASWS-DRLSIAAVNG MAV_3109|M.avium_104 AARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWG-ERLNIATVNG MUL_2266|M.ulcerans_Agy99 AAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFG-DRVSIAAING MLBr_00135|M.leprae_Br4923 AAMLVVARGRLMQSMPAGGTMWAVAASE---DEVVSLLG-EGVGIAAINA TH_4621|M.thermoresistible__bu GVKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIAS .. :: *.:* : * * :: : ::. . Mflv_0405|M.gilvum_PYR-GCK -ANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFES MAB_0939|M.abscessus_ATCC_1997 -ANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEA MSMEG_0408|M.smegmatis_MC2_155 -ANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFES Mvan_1003|M.vanbaalenii_PYR-1 -DNTVLSGPAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFES Rv1661|M.tuberculosis_H37Rv VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIA Mb1689|M.bovis_AF2122/97 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIA MMAR_2471|M.marinum_M VSAIVVSGEVDALDALIGRCEADDIRARRIDVDYASHSAQVEAIRAELAE MAV_3109|M.avium_104 ISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAE MUL_2266|M.ulcerans_Agy99 PSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTE MLBr_00135|M.leprae_Br4923 PESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVR TH_4621|M.thermoresistible__bu PESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEE *:.* : : .. * ** :: : .: Mflv_0405|M.gilvum_PYR-GCK YARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHT MAB_0939|M.abscessus_ATCC_1997 YANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRT MSMEG_0408|M.smegmatis_MC2_155 FAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRT Mvan_1003|M.vanbaalenii_PYR-1 CADRFEFGTPQRTLVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVRT Rv1661|M.tuberculosis_H37Rv ALRGIEPRTSTVAFFSTVTG-ELMDTAGVNAEYWYRSIRQPVQFERAVRN Mb1689|M.bovis_AF2122/97 ALRGIEPRTSTVAFFSTVTG-ELMDTAGVNAEYWYRSIRQPVQFERAVRN MMAR_2471|M.marinum_M ALDGIAPQSTSTAFISTVTG-EFTDTAGLDADYWHRSIRQTVQFERAIRT MAV_3109|M.avium_104 ALRGIAPRSSAVAFFSTVTG-ELMDTAALDGDYWFRSIRQTVQFERAVRG MUL_2266|M.ulcerans_Agy99 VLAGIEPLSSRTAFFSSVTG-SRLDTAELDAEYWYRNIRQTVQFDQAVRS MLBr_00135|M.leprae_Br4923 VAAQVEVRKPQIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRFVDSARH TH_4621|M.thermoresistible__bu ILADLQPMTPTVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQA . . :. . ** : *.* : : Mflv_0405|M.gilvum_PYR-GCK LADMNCKLLVEIGPRPVLTAAALSAWPDP----ATSPRVIASLRRTTADQ MAB_0939|M.abscessus_ATCC_1997 LADMNCKVLLEIGPQPVLTAAALRAWPDP----ATAPRAIASLRRNTADH MSMEG_0408|M.smegmatis_MC2_155 LADMNCRVLLEIGPRPVLTATALAAWPDP----ATTPQVLASLRPTTADH Mvan_1003|M.vanbaalenii_PYR-1 LADLGCRLLMEIGPQPVLTAAAMRTWPGT----VTAPRVAASMRRKGSDR Rv1661|M.tuberculosis_H37Rv AFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGV Mb1689|M.bovis_AF2122/97 AFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGV MMAR_2471|M.marinum_M AFNSGCQVFIESSPHPVLMAGIEETLAGQQD--SGEAIVIPSLGRDDGGL MAV_3109|M.avium_104 AAEAGYRAFIECSPHPVLTAAIEETMP-----DGGQGCVIPSLGRDDGGP MUL_2266|M.ulcerans_Agy99 ACGHGYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGL MLBr_00135|M.leprae_Br4923 LQTLGATHFIESGPSSGLMGAIEQSLAP------AEAVVVSMMGKDRPEL TH_4621|M.thermoresistible__bu ALEDGFRVFGELSPHPLLTRAVEQTARGLD----MPVAALPAMRREQEMP . : * .* . * : . . : Mflv_0405|M.gilvum_PYR-GCK RQITEAVADAYVLGHLPRFAAFRRD-GARVLDLPTYPFEHRQYWFSDSRE MAB_0939|M.abscessus_ATCC_1997 RQITEAAADAYVLGHLPDFGAFQHA-PARKLDLPTYPFERRQYWFSDKRD MSMEG_0408|M.smegmatis_MC2_155 RQITEAVAAAYAAGHLPDFRAFRQP-DARKLDLPTYPFEHRQFWFSDNRA Mvan_1003|M.vanbaalenii_PYR-1 RQITEALAQAYVAGHRPETAARQHG-RGRLLDLPTYPFQHRAYWFP---- Rv1661|M.tuberculosis_H37Rv GRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGA Mb1689|M.bovis_AF2122/97 GRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGA MMAR_2471|M.marinum_M QRFWLSVAQAHVAGVRVDWASIIG--AGRRVALPTYGFQHRRFWLGQLDA MAV_3109|M.avium_104 DRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDLPTYGFVRQHFWLPGGST MUL_2266|M.ulcerans_Agy99 QRFLASAAAAFVAGVNVDWRGPLD--GAGLVELPTYAFEKRRFWLSG-EG MLBr_00135|M.leprae_Br4923 ASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTD TH_4621|M.thermoresistible__bu HGVRTMVGDLFAAGAAVDFAALYPS--GRLVDAPLPTWTRRKLVLSR-EN . . .. * . : * : :: Mflv_0405|M.gilvum_PYR-GCK ---PVAAAPQR---GARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLN MAB_0939|M.abscessus_ATCC_1997 GDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLNVLT MSMEG_0408|M.smegmatis_MC2_155 IDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLRVLN Mvan_1003|M.vanbaalenii_PYR-1 ----QGQARTAPTDPVHTETVRFLDEERIDELAALLDGPTGSAQTVDVLS Rv1661|M.tuberculosis_H37Rv VGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVG Mb1689|M.bovis_AF2122/97 VGGDLGGVGLVGAEHGLLAAVVQRPDSGGVVLTGRISVVAAPWLADHAVG MMAR_2471|M.marinum_M GRTDVGGLGQAGAAHGLLGAVVERPDSGGVVLTGQLSVALQPWLAGHAVA MAV_3109|M.avium_104 GSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSAQAWLADHAVG MUL_2266|M.ulcerans_Agy99 VSVDASGLGLSAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVS MLBr_00135|M.leprae_Br4923 GTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIG TH_4621|M.thermoresistible__bu GEQQTRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIH * : : : : Mflv_0405|M.gilvum_PYR-GCK RLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGDDTD MAB_0939|M.abscessus_ATCC_1997 KLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADAAG MSMEG_0408|M.smegmatis_MC2_155 KLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAAA--DWILVGDDTA Mvan_1003|M.vanbaalenii_PYR-1 KLAARHRQQRGAQSIADARYQIRWEKSEAPGAARPTTEATTWLLVTHDSR Rv1661|M.tuberculosis_H37Rv PVVLFPG-------TGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-V Mb1689|M.bovis_AF2122/97 PVVLFPG-------TGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-V MMAR_2471|M.marinum_M GTVLFPG-------AGFVELAIRAGDEVGCAAVEELTLSAPLVLPTVGGV MAV_3109|M.avium_104 DTVLFPG-------AGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGV MUL_2266|M.ulcerans_Agy99 GVVVFPG-------TGFVELAIRAVDEVGCSVVNELTLRTPLVLPASGSV MLBr_00135|M.leprae_Br4923 GVVLFPG-------AGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGV TH_4621|M.thermoresistible__bu TVAALPG-------AAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLDEQ . . : : Mflv_0405|M.gilvum_PYR-GCK ATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRIVHV MAB_0939|M.abscessus_ATCC_1997 AAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRIVHV MSMEG_0408|M.smegmatis_MC2_155 AVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYVVHI Mvan_1003|M.vanbaalenii_PYR-1 AAQPIAEVLERRGHPYHIVGLPGSDADAAPAEEALRATVSQ-PRPHILYL Rv1661|M.tuberculosis_H37Rv RVQVVVGGVEQSGTRNVWVYSAAG---QADSSPGWTLHAQG-----VLGV Mb1689|M.bovis_AF2122/97 RVQVVVGGVEQSGTRNVWVYSAAG---QADSSPGWTLHAQG-----VLGV MMAR_2471|M.marinum_M QLQVVVGPADQSDHRTVEVYSRGD---QSLS--EWSLHAEG-----VLAP MAV_3109|M.avium_104 RLQLVVGAPDEAGRRPLSVYSAAA---HQDS--EWMLHAEG-----VLRT MUL_2266|M.ulcerans_Agy99 AVQVVVGAAADSAERSVSIYSRTDTDTDTDAGSVWVCHAEG-----TLGA MLBr_00135|M.leprae_Br4923 QVQVVVAAADESSRRAVSVYSRGD-----QSHGGWLLNAEG-----LLEV TH_4621|M.thermoresistible__bu TEVSAVASAVEPGTLEFAVETAKDGEHERRATAVLGAADDT--------- : Mflv_0405|M.gilvum_PYR-GCK AALDAAESDTSMKSLLRMQHRVLGGTRRLFG--AAVAAQLRSPMWLVTRG MAB_0939|M.abscessus_ATCC_1997 AALAGQGS-SSAQSLLRIQHQVLGGTRRLFR--AAAAAELRAPIWIVTRG MSMEG_0408|M.smegmatis_MC2_155 AAGDGAAA--PMRDLLRVQHRTLGGLRRLFR--AANDAELRSPIWLVTRD Mvan_1003|M.vanbaalenii_PYR-1 AALEEPGG-SAAETLGWMQHRVLAAARRLFQ--LAATAGARAPIWLITAG Rv1661|M.tuberculosis_H37Rv GSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRG Mb1689|M.bovis_AF2122/97 GSVQPAAELSVWPPVGARAMDVADGYQVLAARGYGYGPAFRGLQALWRRG MMAR_2471|M.marinum_M AAVASVGQLTAWPPEGATALDLGGVYDRLAARGYEYGPAFRGLQAVWESG MAV_3109|M.avium_104 GTVTPAGDLSIWPPIGATAVDVTGGYARLAQRGYEYGRAFRGLRAMWQRG MUL_2266|M.ulcerans_Agy99 DSAQPAADLSAWPPAGAIAVDVADGYERLDARGYGYGPAFRGLTAMWARG MLBr_00135|M.leprae_Br4923 DAAEATVDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQGLVAIWRRG TH_4621|M.thermoresistible__bu -EPPQAHDIDALLAEHPTRIEGDELRQWFDQRGVQFGPAFTGLTAARIPE : . Mflv_0405|M.gilvum_PYR-GCK ---AQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLG----GGTS MAB_0939|M.abscessus_ATCC_1997 ---AQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLS----DAGT MSMEG_0408|M.smegmatis_MC2_155 ---GQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLS----GADT Mvan_1003|M.vanbaalenii_PYR-1 ---AQRITGDETVEPAQTSLWGFGRAAALEQPELWGGLADVT----TGDA Rv1661|M.tuberculosis_H37Rv ---AEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEG----EQQT Mb1689|M.bovis_AF2122/97 ---AEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEG----EQQT MMAR_2471|M.marinum_M ---DEIFAEVALPEDAGAQIGGFGIHPALLDAALHALVLTAE----QNQT MAV_3109|M.avium_104 ---DEIFAEVALPDD-AAAGDDFGVHPVLLDAALHALGVAGE----KDQT MUL_2266|M.ulcerans_Agy99 ---EELFAEARLPEA-AGSTSGFGVHPALLDAALHTAVIANP----DADL MLBr_00135|M.leprae_Br4923 ---SELFAEVVAPTG--VVVDGMGMHPALLDAVLHALGLAIENTQATTEM TH_4621|M.thermoresistible__bu GTVTSVLAEVGLPGQIRSQQAPYGIHPALLDACFQSVAAHPDVQGAGSGL . . * . : . . Mflv_0405|M.gilvum_PYR-GCK DEWSRLLNRIAA------------THDPAVMEDQVAVRGSTSYVPRLVHR MAB_0939|M.abscessus_ATCC_1997 DEWAQFIGRVSV------------SGEASTREDQLALRGQAVHVPRLVRR MSMEG_0408|M.smegmatis_MC2_155 -EWPRLIARITS------------PRDG---EDQIALRGDAVYAPRLVRR Mvan_1003|M.vanbaalenii_PYR-1 EEWSALIDHIVA------------APTS---EDQIAVRGREIHVARLTRC Rv1661|M.tuberculosis_H37Rv MLPFSWQGVCLH------------ASGAARVRVRLAPVGRGAVSVELADP Mb1689|M.bovis_AF2122/97 MLPFSWQGVCLH------------ASGAARVRVRLAPVGRGAVPVELADP MMAR_2471|M.marinum_M VLPFAWQGVSLH------------AAGASRCRVRIAQSRSGSVAMELADS MAV_3109|M.avium_104 VLPFSWQGVALH------------ASGASRARVRIAPAGAGAVSVELADG MUL_2266|M.ulcerans_Agy99 VLPFSWQGVSLH------------AAGAASVRVRIAPVGPSSVSVELADD MLBr_00135|M.leprae_Br4923 RLPFCWRGVSLH------------AGGAGRVRARFTSAGADAIAVDIADS TH_4621|M.thermoresistible__bu LLPLGVRRLQAFGPTRGARYCYARVTDADGSKAEADLDVLDEHGNVLLRV . . : Mflv_0405|M.gilvum_PYR-GCK DTLPSGKPLHLRADATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTP MAB_0939|M.abscessus_ATCC_1997 EELPSGKPLEVRSDATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREP MSMEG_0408|M.smegmatis_MC2_155 TGEPSDTPLPVREDRTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRREP Mvan_1003|M.vanbaalenii_PYR-1 AEKANAAALELRREATYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRSA Rv1661|M.tuberculosis_H37Rv QGLP---VLSVRQLMVRPVSAAALSR--STAGD---RGLLEMIWTPVPLE Mb1689|M.bovis_AF2122/97 QGLP---VLSVRQLMVRPVSAAALSR--STAGD---RGLLEMIWTPVPLE MMAR_2471|M.marinum_M AGLP---VLTVRDLAFRPVSDQTSSA--GTAGG---GGLLEVVWSPLARP MAV_3109|M.avium_104 AGLP---VLSVRSVTMRPVSPGQLSAAMGTAQP---SGLLDVIWSPIALG MUL_2266|M.ulcerans_Agy99 LGLP---VLSVKAMVARPVSEQQMRAVVSASGP---DRLFEVVWTPMTVA MLBr_00135|M.leprae_Br4923 AGLP---VLTVRSLVTRAMTAEQLRTAVTAAGGALEQGPMDLVWSPIPLS TH_4621|M.thermoresistible__bu QGLLMGGAAADGDDRDRVLGERLLTIEWQRRDLPEADSAAGKWLLVSTSA : Mflv_0405|M.gilvum_PYR-GCK DEAAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIV MAB_0939|M.abscessus_ATCC_1997 GEAARQRIDALAA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGIV MSMEG_0408|M.smegmatis_MC2_155 GDDARRRLDGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIV Mvan_1003|M.vanbaalenii_PYR-1 SDTVRQRIDAMRERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGIV Rv1661|M.tuberculosis_H37Rv GGDIGDD-------------------AVVWELPPHAG-AQAGGDVLAAVY Mb1689|M.bovis_AF2122/97 GGDIGDD-------------------AVVWELPPHAG-AQAGGDVLAAVY MMAR_2471|M.marinum_M GDDTADIP------------------VTLWDLASQVE-LSAG--AVESTY MAV_3109|M.avium_104 GNDLGDE-------------------VTLWEPG------EHGGDVVKSVH MUL_2266|M.ulcerans_Agy99 ATDAAPAY------------------ELFESIA-------ADGDPLSGTY MLBr_00135|M.leprae_Br4923 SDGHGGGLPSVVSWADYCAGRGNDTGVVVWEFGSASAGAQAPVDSVAAVY TH_4621|M.thermoresistible__bu TADVSATRLSDALKQAGAESTSMCWPQQADHADNVDRFRAGIADGVTGVV : . Mflv_0405|M.gilvum_PYR-GCK HAAGEIGTTPLADLD--------------------DAEVDRVFAGKVWGA MAB_0939|M.abscessus_ATCC_1997 HAAGEIGTTPLSDLE--------------------DAEVDRVFAGKVWGA MSMEG_0408|M.smegmatis_MC2_155 HAAGEIGTTPLSGLD--------------------DAEVDRVFAGKVWGA Mvan_1003|M.vanbaalenii_PYR-1 HAAGEIGTSPLRTLD--------------------DAEMDRVFAGKVWGA Rv1661|M.tuberculosis_H37Rv RGVHEVLEVLQSWLA--------------------SDATGLGVVVTRGAV Mb1689|M.bovis_AF2122/97 RGVHEVLEVLQSWLA--------------------SDATGLGVVVTRGAV MMAR_2471|M.marinum_M VATHGALGALQSWLA--------------------SDQPGVLAVVTHGAV MAV_3109|M.avium_104 AAVTETLAVLQSWLD--------------------GEGAGVLAVQTHGAV MUL_2266|M.ulcerans_Agy99 QRTHQALAAVQSWLT--------------------EHDSGVLVVATRGAM MLBr_00135|M.leprae_Br4923 SATHAALQVLQFWFG--------------------QDRAGTLVVLTRGAV TH_4621|M.thermoresistible__bu VLTGPKNGNPDDAAARRGSDYVRHLVRITRELAEIDGDAPRLFVVTRGAQ . . . . Mflv_0405|M.gilvum_PYR-GCK WHLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAANAFLDGL-AWRL MAB_0939|M.abscessus_ATCC_1997 WHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAANAFLDGL-AWRL MSMEG_0408|M.smegmatis_MC2_155 WHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFLDGL-AWRL Mvan_1003|M.vanbaalenii_PYR-1 VYLCEEVADMG--LDFFLATSSIASVWGSHGQTAYGAANAFLDGL-ADSL Rv1661|M.tuberculosis_H37Rv GPVDDDVTDLAG-----------AAVWG-----LVRSAQAEHPGR-VVLV Mb1689|M.bovis_AF2122/97 GPVDDDVTDLAG-----------AAVWG-----LVRSAQAEHPGR-VVLV MMAR_2471|M.marinum_M GLADEDVTDLAG-----------SAVWG-----LVRSAQAEHPGR-VVLV MAV_3109|M.avium_104 ALAGEDVSDLAG-----------AAVWG-----LVRSAQAEHPGR-LVLI MUL_2266|M.ulcerans_Agy99 ALAGEDVTDLAG-----------AAVWG-----LVRSAQTENPGR-LVLV MLBr_00135|M.leprae_Br4923 GLVGEGISDLAA-----------AAVWG-----MVRSAQSEHSGK-IVLI TH_4621|M.thermoresistible__bu AVLPQDRPNLEQ-----------AGLRG-----LLRVIGAEHPHLRTTQI : ..: :.: * : : Mflv_0405|M.gilvum_PYR-GCK REQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALA----GLS MAB_0939|M.abscessus_ATCC_1997 REQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTDALA----GLA MSMEG_0408|M.smegmatis_MC2_155 RERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEALA----GMA Mvan_1003|M.vanbaalenii_PYR-1 RARGIPGISVNFGPWAAGMADAKAREQLSRRGVKTLAPADALA----GMA Rv1661|M.tuberculosis_H37Rv DTDGSVAVEDAVGFGAR-SGEPQLVVRRGRVYAARLAPVAAG-----LTL Mb1689|M.bovis_AF2122/97 DTDGSVAVEDAVGFGAR-SGEPQLVVRRGRVYAARLAPVAAG-----LTL MMAR_2471|M.marinum_M DTDGSVELGAVL----N-SGEPQLVVRAGVAYQARLKPAESL-----LRL MAV_3109|M.avium_104 DSDGSLDARAVIP-----CGEPQVVVRQGVAHAARLRPARAG-----ATL MUL_2266|M.ulcerans_Agy99 DSDAAVDAAAVAT-ALA-VGEPQVVLRNGQPYTARVHASRAAD----GIL MLBr_00135|M.leprae_Br4923 DTDSAVDVAVLAD-----LGESQLLVRCNTVHAARLSPAPQL------LA TH_4621|M.thermoresistible__bu DIADDADLDRVAVQLLGGGAEDETAWRDGQWYTARLSLSPLRPEERKQAV .: : : : Mflv_0405|M.gilvum_PYR-GCK DAVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQ MAB_0939|M.abscessus_ATCC_1997 DVVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLA-- MSMEG_0408|M.smegmatis_MC2_155 DVVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGA Mvan_1003|M.vanbaalenii_PYR-1 DVIAASTA---HAVVARIDWATFLPVYQLQRRRAFLSQLEREVPDVPD-- Rv1661|M.tuberculosis_H37Rv PSASAGGWRLVAGGGGTLADVVVAPVAPV------------ELATGQVRV Mb1689|M.bovis_AF2122/97 PSASAGGWRLVAGGGGTLADVVVAPVAPV------------ELATGQVRV MMAR_2471|M.marinum_M PPPGEN-WRLVTGGGGTLDDVKVGGCAPS------------GLMTGQLRV MAV_3109|M.avium_104 G-LPSGAWRLDAGGEGTLGDLVVSRCPRT------------ELADGQVRV MUL_2266|M.ulcerans_Agy99 VPPVDGPWRLGLSSAGTFENLQLEPVPNAGA----------PLGPGQVRV MLBr_00135|M.leprae_Br4923 LPVGESMWRLAADGGGTLEDLVIQPCPEVQA----------PLQAGHMRV TH_4621|M.thermoresistible__bu VDCERDGMRLEIRTPGDLETMELAAFDRVPP------------GPGQIEV . . . Mflv_0405|M.gilvum_PYR-GCK GPAVTASGRTPLVERLTTAP-LQQRKRLLTDYLRDAVAEVTRVDAAEIRE MAB_0939|M.abscessus_ATCC_1997 GVAGAQSGSTQLVERLANAP-VQQRKKLLTDYLRDAVAEVTRVDVSEIRE MSMEG_0408|M.smegmatis_MC2_155 AAPATVPGKPPLVEQLTKAP-VQQRKSLITNYLRNAVAEVTRVDADEIRD Mvan_1003|M.vanbaalenii_PYR-1 ASAPAPSGTTRFVEELTLAP-VEQRRKLVLEYLRAAVAEVTRVDAAEIRD Rv1661|M.tuberculosis_H37Rv AVGAVGVNFRDVLVALGMYP-GGGE---LGVDGAGVVVEVGPGVTGLAVG Mb1689|M.bovis_AF2122/97 AVGAVGVNFRDVLVALGMYP-GGGE---LGVDGAGVVVEVGPGVTGLAVG MMAR_2471|M.marinum_M AVAAVGVNFRDVLVALGMYP-GGGE---LGVEGAGIVTEVGPGVSGVAVG MAV_3109|M.avium_104 AVAAVGVNFRDVLVALGMYP-GGGR---LGAEGAGVVVEVGPAVTGLAVG MUL_2266|M.ulcerans_Agy99 AMRAIAANFRDIMITLGMFT-HDAL---IGGEGAGVVVEIGPEVTEFAVG MLBr_00135|M.leprae_Br4923 AVAAVGVNFRDVVAALGMYP-GQAPP--LGAEGAGVVIEIGPEVTGVAVG TH_4621|M.thermoresistible__bu AVTASSINFADVLIAFGRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVG . . .: : . : * : Mflv_0405|M.gilvum_PYR-GCK DAGFFDLGM-DSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYLLG MAB_0939|M.abscessus_ATCC_1997 DAGFFDLGM-DSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLG MSMEG_0408|M.smegmatis_MC2_155 EAGFFDLGM-DSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLLV Mvan_1003|M.vanbaalenii_PYR-1 EAGFFDLGM-DSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVLG Rv1661|M.tuberculosis_H37Rv DRVMGLLG--LVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLS Mb1689|M.bovis_AF2122/97 DRVMGLLG--LVGSEAVVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLS MMAR_2471|M.marinum_M DAVMGLLG--VVGPEAVVDHRLVTAVPPGWSLQTAASVPVVFLTAFYGLR MAV_3109|M.avium_104 DPVMGLLG--VVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLS MUL_2266|M.ulcerans_Agy99 DAVYGFFPD-GSGTLVAGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFV MLBr_00135|M.leprae_Br4923 DAVMGFLG--GAGPLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLA TH_4621|M.thermoresistible__bu DRVGGLSPNGCWSTFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLH : : . . . .* : : Mflv_0405|M.gilvum_PYR-GCK DVLGLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPGAPNPEAFWDLLS MAB_0939|M.abscessus_ATCC_1997 DVLGLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPGAPDPEAFWDVLS MSMEG_0408|M.smegmatis_MC2_155 EVLGLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPGAPDPESFWELLA Mvan_1003|M.vanbaalenii_PYR-1 DVLGLSEHTV--AQPDTPSTVRTDDPIAIVGMACRFPGADDTDAFWSVLA Rv1661|M.tuberculosis_H37Rv VLAEVAAGQK-----VLVHAGTGGVGMAAVSLARYWG----AEVFVTASR Mb1689|M.bovis_AF2122/97 VLAEVAAGQK-----VLVHAGTGGVGMAAVSLARYWG----AEVFVTASR MMAR_2471|M.marinum_M VLAEVRSGQK-----LLVHAATGGVGMAAVQLARLWG----LEVFATASP MAV_3109|M.avium_104 VLSGLRPGER-----VLVHTATGGVGMAAVQLARHYG----AEVFATASR MUL_2266|M.ulcerans_Agy99 HLANVQPGQR-----VLVHAATGGVGMAAVQLARHLG----LEVYATASK MLBr_00135|M.leprae_Br4923 DLAGIRAGES-----VLIHAGTGGVGMAAVQFARHWG----VEIFVTASR TH_4621|M.thermoresistible__bu DLARLGAGEK-----VLIHSATGGVGLAAIAIARSVG----AQIYATAGS : : : . :* : .: : : Mflv_0405|M.gilvum_PYR-GCK -GGVDAIREVPEDRFDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFF MAB_0939|M.abscessus_ATCC_1997 -GGVDAIREVPEDRFDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFF MSMEG_0408|M.smegmatis_MC2_155 -GGVDAIREVPEDRWDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFF Mvan_1003|M.vanbaalenii_PYR-1 -EGADLIREIPDDRFDINEFYDPDPEAAGKIYSRYGGFLDGVDGFDPEFF Rv1661|M.tuberculosis_H37Rv -AKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFT Mb1689|M.bovis_AF2122/97 -AKWDTLRAMGFDDIHISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFT MMAR_2471|M.marinum_M -GKWDTLRAMGFDDDHIANSRTLEFEEKFRAGTGGVGVDAVLNSLAGEFV MAV_3109|M.avium_104 -GKWDTLRAMGFDDDHIGDSRSPDFEQKFLAATGGAGVDVVLNSLAGEFT MUL_2266|M.ulcerans_Agy99 -GKWDILRAMGFDEDHISDSRSLEFEEKFREVTGGRSVDVVLDSLAGEFV MLBr_00135|M.leprae_Br4923 -GKWDTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFV TH_4621|M.thermoresistible__bu PARRDLLRDMG--IEHVYDSRSTAFADEIRRDTDGYGVDVVLNSLP---- * :* : .: : : .. :: : Mflv_0405|M.gilvum_PYR-GCK GLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGVAA-- MAB_0939|M.abscessus_ATCC_1997 GISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGVGA-- MSMEG_0408|M.smegmatis_MC2_155 GISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGVAA-- Mvan_1003|M.vanbaalenii_PYR-1 GISPREAVWIDPQQRLVLETAWEGLERAGYSAAALRGSRSGVYVGVGA-- Rv1661|M.tuberculosis_H37Rv DASLR----LLPSGGRFIELGKTDIRDGQTVAERHRGVR---YRAFDL-- Mb1689|M.bovis_AF2122/97 DASLR----LLPSGGRFIELGKTDIRDGQTVAERHRGVR---YRAFDL-- MMAR_2471|M.marinum_M DASLR----LLVPGGRFIEMGKTDLRDPQTMAEQHRGVG---YRAFDL-- MAV_3109|M.avium_104 DASLR----LLAPGGRFIEMGKTDVRDPDVVAQRYRGAR---YRAFDL-- MUL_2266|M.ulcerans_Agy99 DASLR----LLGPGGVFLEMGKTDIRDPGVIAQEYPGVR---YRAFDL-- MLBr_00135|M.leprae_Br4923 DASLR----LLVRGGRFLEMGKTDIRDAQEIAANYPGVQ---YRAFDL-- TH_4621|M.thermoresistible__bu GAAQRAGLELLSFGGRFIEIGKRDIYG-DTRLGLFPFRRNLAFHGVDLGL . : * : .:* .: : .. Mflv_0405|M.gilvum_PYR-GCK -NEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTAC MAB_0939|M.abscessus_ATCC_1997 -NEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTAC MSMEG_0408|M.smegmatis_MC2_155 -NEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTAC Mvan_1003|M.vanbaalenii_PYR-1 -NEYSHLLSGGSLDGIEAQFITGNALNVIAGRVSFTLGLEGPAVAVDTAC Rv1661|M.tuberculosis_H37Rv -VEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARH Mb1689|M.bovis_AF2122/97 -VEAGPDRIAAMLSEVVGLLAAGVLARLPVKTFDARCAPAAYRFVSQARH MMAR_2471|M.marinum_M -IEAGPDLIARMLAELSRLLCAETLTPLPIKTFDVRLARQAYRFVSQARH MAV_3109|M.avium_104 -MEAGPDRTAAMLAEIVGLLRAGVLTPLPLKTFDVRCASTAYRYVSQARH MUL_2266|M.ulcerans_Agy99 -FEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVRRAPAALRYLSQARH MLBr_00135|M.leprae_Br4923 -SEAGPVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARH TH_4621|M.thermoresistible__bu MADSHPHKIRELLETVYRLTADGVLPMPQSTHYPLAEAATAIRVMSAAEH : : : . . : Mflv_0405|M.gilvum_PYR-GCK SSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVGR MAB_0939|M.abscessus_ATCC_1997 SSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGR MSMEG_0408|M.smegmatis_MC2_155 SSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVGR Mvan_1003|M.vanbaalenii_PYR-1 SSSLVAVHQACQGLQSGDCDLALAGGVNVLLSPATTIATSRARMLSPDGR Rv1661|M.tuberculosis_H37Rv IGKVVLTIPDGPGGQSG-----LAGGTVVVTGGTGMAGSAVATHLVRRHG Mb1689|M.bovis_AF2122/97 IGKVVLTIPDGPGGQSG-----LAGGTVVVTGGTGMAGSAVATHLVRRHG MMAR_2471|M.marinum_M IGKVVLTLPDETGAVPAGA---LAGGTVIITGGTGMAGTALARHVVSRHR MAV_3109|M.avium_104 IGKVVLTVPSGPGEVLSGCGGGLAQSTVLITGGTGMAGSALARHLVDRYR MUL_2266|M.ulcerans_Agy99 VGKVVMTMPADQGGALG-------GGTVLITGGTGMAGSALARHLVAHHG MLBr_00135|M.leprae_Br4923 IGKVVLTMPSALADGLA-------EGTVLITGASGAIGGVLARHMVSAYG TH_4621|M.thermoresistible__bu VGKLVLDVPHTG-----------RADVVVPPEQASPFRSDGAYIVTGGMG . :* .. : * : Mflv_0405|M.gilvum_PYR-GCK CKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGAS MAB_0939|M.abscessus_ATCC_1997 CKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGAS MSMEG_0408|M.smegmatis_MC2_155 CKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGAS Mvan_1003|M.vanbaalenii_PYR-1 CKTFDAAADGYVRGEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDGAS Rv1661|M.tuberculosis_H37Rv VANLVLVSRSGEQADRA-----AEVAALLREGGAQVAVVSCDVADRD-AL Mb1689|M.bovis_AF2122/97 VANLVLVSRSGEQADRA-----AEVAALLREGGAQVAVVSCDVADRD-AL MMAR_2471|M.marinum_M VANVILVSRSGAQAEGT-----SELLGQLQDAGAEAAVVACDVSDRD-AV MAV_3109|M.avium_104 VGHVVLVSRTGAQAAGA-----AELVDELQRAGASASVLACDVGDRD-AV MUL_2266|M.ulcerans_Agy99 VAHLVLISRRGPAAPGA-----TELVAELSAAGAQVEVVACDAADRP-AL MLBr_00135|M.leprae_Br4923 VRHLVLASRRGDRAEGA-----VELAAELVGAGAKIQVVACDVADND-AV TH_4621|M.thermoresistible__bu GLGLYLAGEMAAAGA-G------CIVLNGRSAPSGEALRTIEQLRAAGTE . . . : . : . : Mflv_0405|M.gilvum_PYR-GCK SGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQAA MAB_0939|M.abscessus_ATCC_1997 SGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAA MSMEG_0408|M.smegmatis_MC2_155 SGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQAA Mvan_1003|M.vanbaalenii_PYR-1 GGLTVPNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQAA Rv1661|M.tuberculosis_H37Rv AALLAGLDPRYP-LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWN Mb1689|M.bovis_AF2122/97 AALLAGLDPRYP-LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWN MMAR_2471|M.marinum_M AELLAQVPARYP-LRGVIHAAGVLDDGLIASLTPQRVDTVLRAKIDGAWN MAV_3109|M.avium_104 ATMLAGLPSGYP-LRGIVHAAGILDDGLLSSLTPDRVDAVLRAKVDGAWN MUL_2266|M.ulcerans_Agy99 AKVIAENPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAWN MLBr_00135|M.leprae_Br4923 RGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWN TH_4621|M.thermoresistible__bu VIVECGXXXRGQPVEVAVPTELRHADEHPDRRGAQLCDEFARGEQGAQRN : : : . .. . Mflv_0405|M.gilvum_PYR-GCK AAAYAGARDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQS MAB_0939|M.abscessus_ATCC_1997 AAAYGGSRDADRPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQS MSMEG_0408|M.smegmatis_MC2_155 AAAYGAGRDADRPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLPQS Mvan_1003|M.vanbaalenii_PYR-1 GAVLGAGRDPDRPLLMGSVKTNVGHLESASGVAGLIKVVLSLQHEMLPRH Rv1661|M.tuberculosis_H37Rv LHELTEDMDLSAFVVFSSMAGIVGTPAQGN-----YAAANAFLDGLVAYR Mb1689|M.bovis_AF2122/97 LHELTEDMDLSAFVVFSSMAGIVGTPAQGN-----YAAANAFLDGLVAYR MMAR_2471|M.marinum_M LHELTRGLNLSAFVLFSSMAGIIGTAGQGN-----YAAANSFLDGLAVHR MAV_3109|M.avium_104 LHELTKDLDLSAFVVFSSMAGIVGTPGQAN-----YAAANSFLDGLVAHR MUL_2266|M.ulcerans_Agy99 LHELTRDLDLSAFVMFSSMAGVVGSSGQAN-----YAAANTFVDGLAAHR MLBr_00135|M.leprae_Br4923 LHEATRDLDLLMFVLCSSIAATVGSPGQGN-----YSAANAFLDGLAAYR TH_4621|M.thermoresistible__bu QHRTDAGEGQRDAHPPGAVGHDQPDPGALS-------------------D . .:: . Mflv_0405|M.gilvum_PYR-GCK LHFDTPSPHIPWDSLPVRVVDTAMPWQPNGRPRRAGVSSFGFTGTNAHVL MAB_0939|M.abscessus_ATCC_1997 LHFDNPSPHIPWESLPVRVVDKAIPWQANGRPRRAGVSSFGFTGTNAHVL MSMEG_0408|M.smegmatis_MC2_155 LHFENPSPHIPWDALPVRVIDEPVPWQTNGRVRRAGVSSFGFTGTNAHVL Mvan_1003|M.vanbaalenii_PYR-1 LHFKTPSPHIPWDRLAVRVVAEPTPWRADGRPRRAGVSSFGFSGTNAHVV Rv1661|M.tuberculosis_H37Rv RSRGLAGLSVAWG-LWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGF Mb1689|M.bovis_AF2122/97 RSRGLAGLSVAWG-LWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGF MMAR_2471|M.marinum_M RALGLPGVSVAWG-LWEQASAMTRHLGERDKARMSRVGLATLSTEHALEL MAV_3109|M.avium_104 RADGLAGLSLAWG-LWEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAA MUL_2266|M.ulcerans_Agy99 RAHGLPAISLGWG-LWDQASDMTGGMDAADRARLGREGVLALSSDEAMEL MLBr_00135|M.leprae_Br4923 QAAGLAGTSLAWG-LWEQPGGMNAHLSSRDLARISRSGLAPMNPAQALEL TH_4621|M.thermoresistible__bu TGLDERGGQFPGVGVQIPVADPGVGIDHRGAVRVDSGVPAQQG------- . . : . * Mflv_0405|M.gilvum_PYR-GCK IEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALVAL MAB_0939|M.abscessus_ATCC_1997 IEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSPEALAAV MSMEG_0408|M.smegmatis_MC2_155 VEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSPEALVEL Mvan_1003|M.vanbaalenii_PYR-1 LEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAGVLPISARSPEALTAL Rv1661|M.tuberculosis_H37Rv LDTALQADRAVVVAAR--------LDRAALAGAGAA--LPALFSQLAAGP Mb1689|M.bovis_AF2122/97 LDTALQADRAVVVAAR--------LDRAALAGAGAA--LPALFSQLAAGP MMAR_2471|M.marinum_M FDAAVVADRAVVVATR--------LDANALKSNSAA--LPPLLGELAARP MAV_3109|M.avium_104 FDAAMLVETPVLVAAR--------LDRAALSENIAA--LPPLLRELAAGP MUL_2266|M.ulcerans_Agy99 FDTALIVNQAFLAPAR--------IDLAALRAHAVA--VPPMFSDLVSAP MLBr_00135|M.leprae_Br4923 FDAALVIDHPFMVTAL--------LDRAALDAQAQAGALPPLFSRLVRRS TH_4621|M.thermoresistible__bu ------------------------VDGEVVRHRTLSSVRSGRSSRWTAPG . Mflv_0405|M.gilvum_PYR-GCK AQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAALVVDSVESARIALTD MAB_0939|M.abscessus_ATCC_1997 AQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREGLLE MSMEG_0408|M.smegmatis_MC2_155 ARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREGLAA Mvan_1003|M.vanbaalenii_PYR-1 ARRYESWLTAHPDADIADVCYTAGAGRSHFEHRAALVVDSVDGARDLLAG Rv1661|M.tuberculosis_H37Rv TRRRI---DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR Mb1689|M.bovis_AF2122/97 TRRRI---DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR MMAR_2471|M.marinum_M KRRVISDADAGDNIAAATGLVARLHGLSAEQRQRELVDVVCSNAATVLGR MAV_3109|M.avium_104 TRRVI---DDADVTASMSGLAARLHGLSPEARRRELVDLVCGNAAMVLGV MUL_2266|M.ulcerans_Agy99 TRRQID--AALATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGT MLBr_00135|M.leprae_Br4923 RRRQIE--DPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGR TH_4621|M.thermoresistible__bu SRCGSGRRYGGESCRRTTGPAAGAAARRGRTRRRRRPRRPPPPPDRVRHR : . Mflv_0405|M.gilvum_PYR-GCK LAQNRLRPGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVFADTV MAB_0939|M.abscessus_ATCC_1997 LAQNRLRPGVVRGEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVFAETV MSMEG_0408|M.smegmatis_MC2_155 LAEGRTPAGVVRGEHVHRPTTAWLFTGQGSQYPGMARELFDTQPVFAQTV Mvan_1003|M.vanbaalenii_PYR-1 LAEDRLGPGAVRGVCGDPPKTAWLFTGQGSQYPGMARELFDTEPVFRDTV Rv1661|M.tuberculosis_H37Rv SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLT--LSPTLIFDYPTP Mb1689|M.bovis_AF2122/97 SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLT--LSPTLIFDYPTP MMAR_2471|M.marinum_M SSTADINAHRAFQELGFDSLTAVELRNRLKTATGLT--LSPTLIFDYPSP MAV_3109|M.avium_104 PDPADINAGRAFQDLGFDSLTAVELRNRLKNATGLT--LSPTLIFDYPTP MUL_2266|M.ulcerans_Agy99 ITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVTGLS--LSPTLIFDYPTP MLBr_00135|M.leprae_Br4923 PSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATGLT--LPPTVIFDHPTP TH_4621|M.thermoresistible__bu AGPAHGPVRR---------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TRCADAVADLLPRPLLDVMFAGGREAGV---------------------- MAB_0939|M.abscessus_ATCC_1997 TRCAEAVKDIVTRPLLEVMFATDRETGG---------------------- MSMEG_0408|M.smegmatis_MC2_155 RQCAEAVADMLPRPLLDVLFATDRET------------------------ Mvan_1003|M.vanbaalenii_PYR-1 TRCAEAIGDTLPRPLLEVLFDTDGDN------------------------ Rv1661|M.tuberculosis_H37Rv ATLAEHLDSRLVTASGSDQQSLSDRVD----------------------- Mb1689|M.bovis_AF2122/97 ATLAEHLDSRLVTASGSDQQSLSDRVD----------------------- MMAR_2471|M.marinum_M AALAEHLGIRLATAT--AQPDLMRRFD----------------------- MAV_3109|M.avium_104 VVLAEHLDSRLAGSGGDDQPDLMGRFN----------------------- MUL_2266|M.ulcerans_Agy99 NGLANYIRAELAGAPQEVKHTPAVRVTGDDPIAIVGMSCRYPGGIESPDD MLBr_00135|M.leprae_Br4923 TAVAEYVAQQMLKSR----------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -----------------PPTETLRHTS----------------------- MAB_0939|M.abscessus_ATCC_1997 -----------------KAGEALRHTS----------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------ADLLQHTS----------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------GQTLRHTS----------------------- Rv1661|M.tuberculosis_H37Rv -----------------DITRELVVLLD-QPDLS---------------- Mb1689|M.bovis_AF2122/97 -----------------DITRELVVLLD-QPDLS---------------- MMAR_2471|M.marinum_M -----------------DLARELDKLIN-RPDWT---------------- MAV_3109|M.avium_104 -----------------DITRELQALLG-APHWN---------------- MUL_2266|M.ulcerans_Agy99 LWDMLMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGD MLBr_00135|M.leprae_Br4923 ----------------------PAES------------------------ TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------FAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVA MAB_0939|M.abscessus_ATCC_1997 ---------FAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVA MSMEG_0408|M.smegmatis_MC2_155 ---------FAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVA Mvan_1003|M.vanbaalenii_PYR-1 ---------YAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVA Rv1661|M.tuberculosis_H37Rv --------ANVKAHLRTRLQTMLTSLTT--------EDDDIAAATESQLF Mb1689|M.bovis_AF2122/97 --------ANVKAHLRTRLQTMLTSLTT--------EDDDIAAATESQLF MMAR_2471|M.marinum_M --------HEDKGKLSGRLHDILADLS---------ADDDITTASESQLF MAV_3109|M.avium_104 --------SDDKAVLRARIHGLLGALPAGDGPDSAPLDEDLEAATESQLF MUL_2266|M.ulcerans_Agy99 FEPAFFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFA MLBr_00135|M.leprae_Br4923 -------------------------------------GDETSQAVEPKVE TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GVFSLEDGAR---------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GVFSIEDGAR---------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 GVFSLDDGAR---------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 GVFGLEDGAR---------------------------------------- Rv1661|M.tuberculosis_H37Rv AILDEELGS----------------------------------------- Mb1689|M.bovis_AF2122/97 AILDEELGS----------------------------------------- MMAR_2471|M.marinum_M AILDEELGS----------------------------------------- MAV_3109|M.avium_104 AILDEELGR----------------------------------------- MUL_2266|M.ulcerans_Agy99 GVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACS MLBr_00135|M.leprae_Br4923 EVSVHA-------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SSLVALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRC MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 KAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASN MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TNAHVIVEAAPRVEVGGSSGGAVPVVPWVVSAKSGSALGAQAARLAAHVR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SHDELDVADVGWSLAGRSTFEHRAVVLGADRDGLLAGLDELAGDEFGGAS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEAFNTVVGELDR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 HLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLESWGVRPDFVM MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -----------------------LMAERGRLFGSLPEGGRMVAVFADAKR MAB_0939|M.abscessus_ATCC_1997 -----------------------LIAERGRLFGGLPAGGRMVAVFSDAKH MSMEG_0408|M.smegmatis_MC2_155 -----------------------LMAERGRMFGSLPEGGRMVAVFADAEH Mvan_1003|M.vanbaalenii_PYR-1 -----------------------LVADRGRLFGGLPVGGRMVAVFTDAEV Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GHSVGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAVQATEQE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VEQVAADFPRVSVGAYNGPNTVLSGPGEDLEQIVGTFGEDGIRCTWLETS MAB_0939|M.abscessus_ATCC_1997 VEQIAGEFPRVSVGAYNGPNTVLSGPGEDLEQAVARFQEEGIRCTWLETS MSMEG_0408|M.smegmatis_MC2_155 VEQVAGEFPRVSVGAYNGPNTVLSGPGEDLEEIVERFEDEGIRCTWLATS Mvan_1003|M.vanbaalenii_PYR-1 VEDFADEFPQVSVAAYNGPNTVLAGPASDLEQIVAGCSGEGIRTTWLDTS Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VLPLLGAQVSIAT-INGPASVVISGAQDAVSAVAEQLRADGRRVHRLAVS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK HAFHSELLDPVLDEFESYAAQLQFAAPTLPLVCNRTGAVLTGQTSLDAQY MAB_0939|M.abscessus_ATCC_1997 HAFHSELLDPILDEFESYAAQVQFAAPTLPLVCNRTGAVLTAQTPIDGQY MSMEG_0408|M.smegmatis_MC2_155 HAFHSELLDPVLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQTPLDAQY Mvan_1003|M.vanbaalenii_PYR-1 HAFHSALLDPVLDEFESCAARLAYAAPTRPLVCNRTGAVVTGPGVIDAQY Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 HAFHSPLMDPMIDEFATVAGELTVNAPTIGIISNLT-GQLAGEDFGSAAY MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK WRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAP MAB_0939|M.abscessus_ATCC_1997 WRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPP MSMEG_0408|M.smegmatis_MC2_155 WRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAP Mvan_1003|M.vanbaalenii_PYR-1 WRRHARQPVQFAESVRTLADLGCSVLMEIGPQPFLIAAALRVWPESAATP Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 WKRHVRDAVRFADSIRFAQSAGAARFLEVGPSIGLTASIEEVLSDAAVTN MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --RAIASLRKGVADRRQIADALAAAYIGGHKPDFAALHEQRGVRLELPTY MAB_0939|M.abscessus_ATCC_1997 --RAIVSLRKGVEDRRQIADALASAYVSGHRPNFAALQRHPRRTVELPTY MSMEG_0408|M.smegmatis_MC2_155 --RAVASLRKGVADRRQIADALASAYVGGHRPDFAAVHRQPRRPVELPTY Mvan_1003|M.vanbaalenii_PYR-1 --RAIPSLRKGPDARRQLAEAVAAAYIAGHRLDFTGHDGGPHRRLPLPTY Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PVATASALRKDRPEPVSLVSALAGVFVAGTAVDWRAVVGQS-HFVELPTY MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PFQRRRFWPKSAGMAIDGR---VGASAGSGILGSGKDLASGDSVYTSRLS MAB_0939|M.abscessus_ATCC_1997 PFQRRRFWPKSSGTAIEG-----GGGLPSGILGRGEDLASGDSVYISRLS MSMEG_0408|M.smegmatis_MC2_155 PFQRRRFWPKASSIAVDG------GTAASGILGSGKDLASGDTIYTSRLS Mvan_1003|M.vanbaalenii_PYR-1 PFQHRSYWPKTAGIRSDG-------SSGSGLLGSAQDLASGDIVHTSRLS Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AFERRRFWLSGDAVPADAAGLGLQAGEHALLGAVVELPASGGVVLTGRLS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VKTQPWLSDHVIYGTVVVPGATYAAMALAAVGTPAHAKDVFFYEPIILPE MAB_0939|M.abscessus_ATCC_1997 VRSQPWLSDHVIYGTVVVPGATYAAMALAAVGTPARAKDVFFYEPIILPE MSMEG_0408|M.smegmatis_MC2_155 VKSQPWLADHVIYGTVVVPGATYAAMALAAVGTPARLKDVFFYEPIILPE Mvan_1003|M.vanbaalenii_PYR-1 VKTQPWLSDHVIYGTVVVPGATYAAMALAAMPTPARVQEVFFYEPIILGD Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAAPLVL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KSSREVQLTVHPSVDGE-SKFQVHSRPYGERGAEWALNAEGVVASGVGD- MAB_0939|M.abscessus_ATCC_1997 KSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDD MSMEG_0408|M.smegmatis_MC2_155 KASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSD- Mvan_1003|M.vanbaalenii_PYR-1 KDSREVQLMLHRTDDADGWTFEVHSRPYGDRDADWSRNASGTVAAGVGD- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PSGGSVAVQVVVGSPDDSGARAVSVYSRGDAGSDWVLHAEGSLGSGSPEP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLKS MAB_0939|M.abscessus_ATCC_1997 AEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLKS MSMEG_0408|M.smegmatis_MC2_155 --PDAAADEQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKS Mvan_1003|M.vanbaalenii_PYR-1 ----AAPDAAADPVDNAIERLTRTRPQQLFDAFADNDLAWGPAWCSSLRS Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 A---------TDLSTWPPVGAVEVENADGYQQLAERGYGYGPAFR-GLNA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAE MAB_0939|M.abscessus_ATCC_1997 LWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAE MSMEG_0408|M.smegmatis_MC2_155 LWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAE Mvan_1003|M.vanbaalenii_PYR-1 LWVGTGEAVGDIAVGAELGEHLGREPIHPVLLDLCTGIAGAALLAAAAQT Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 MWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDAALHAVILASDGADDFG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDR MAB_0939|M.abscessus_ATCC_1997 QGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDR MSMEG_0408|M.smegmatis_MC2_155 QGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDL Mvan_1003|M.vanbaalenii_PYR-1 DADPELFLPLRYGRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDFLDH Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VPEGSVLVPFAWQGVTLHAAGASAVRARI------APAGPSAVSIELSDG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DGRHLGGVREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPVP----ES MAB_0939|M.abscessus_ATCC_1997 DGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVAVPPVAGEG MSMEG_0408|M.smegmatis_MC2_155 GGRALGGIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPPP------ Mvan_1003|M.vanbaalenii_PYR-1 DGRNLGGIREFTVKRAPREALLRGLGADATRLIYRVGWRETSPP---VRD Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LGLPVLSVASMLARPVTDQQLRAAVSGAGPDRLFGVDWTAQPSA------ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GDGAAPQGTWLIGGFDELAVSVPGCIPADR----------------TNPE MAB_0939|M.abscessus_ATCC_1997 EESAASIGTWLIAGFDELAAKVPGCIPLNRE---------------TDPE MSMEG_0408|M.smegmatis_MC2_155 PSADDAVGTWLIAGFDELAAKVPGCVPIDRN---------------TDLQ Mvan_1003|M.vanbaalenii_PYR-1 DGALGPSSTWLVAGLDALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDE Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 --ELQPVPVRIWGTVESEGDDDPGASVVFES------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SLRQLLTDAHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLG MAB_0939|M.abscessus_ATCC_1997 LLGEVLVAAKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLS MSMEG_0408|M.smegmatis_MC2_155 VLGEVLSQAHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLS Mvan_1003|M.vanbaalenii_PYR-1 HWRRLFALADERRAPVAGVVLGVTGRARPEE-PSADFAARLEAQIRDVLG Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ------------------------------VPQAGEVVAGVYAATAAVLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAI MAB_0939|M.abscessus_ATCC_1997 AVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTI MSMEG_0408|M.smegmatis_MC2_155 AVHAAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTI Mvan_1003|M.vanbaalenii_PYR-1 AVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLI Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VLRSWL-----SRDGAGQLIITTRGAVALPDEDVTDLAGSAVWGLVRSAQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NEEPALRCRLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLL MAB_0939|M.abscessus_ATCC_1997 NEEPALRAKLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLL MSMEG_0408|M.smegmatis_MC2_155 NEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLL Mvan_1003|M.vanbaalenii_PYR-1 AEEPGLRCLLVDLDGSEDAGPALARLLGAP-GDEPELALRQGRLLVPRLL Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TEHPGRIVLVDTDAQLDEHAVAAVLAAGEPQVLWRNGEVYTARVHGSRAV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PWSRSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVP--PPAEGYVQVRV MAB_0939|M.abscessus_ATCC_1997 PWSRTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVP--APDEGYVQVRV MSMEG_0408|M.smegmatis_MC2_155 PWARSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVP--EPDEGYVQVRV Mvan_1003|M.vanbaalenii_PYR-1 PWSRSGQLAIPRGTDYVLAPTERGVLDNLRVSETEVT--APPEGHVQVRV Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ----AGLLVPPGDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVAL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK EAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYG MAB_0939|M.abscessus_ATCC_1997 EAAGLNFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYG MSMEG_0408|M.smegmatis_MC2_155 EAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYG Mvan_1003|M.vanbaalenii_PYR-1 EAAGLNFRDVLNALGLYPGDPGPIGGELAGVVTAPGPDVDGFDVGQRVFG Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SAMAANFRDVMIALGLYPDPDAAMGVEGAGVVVETASPDGRFAVGDRVVG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SMQGAFASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVR-LSFDWAQVK MAB_0939|M.abscessus_ATCC_1997 SMQGAFGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVR-LSFDWAQLK MSMEG_0408|M.smegmatis_MC2_155 SMQGAFASRFNVPAQFLAPIPDGIGAVEAATIPAAALTVR-LAFDWAQLK Mvan_1003|M.vanbaalenii_PYR-1 FAVGAFASRVNVPVQFLAPVPEGISAVAAATTPAAVLTAG-LAFDWAALR Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LFPEGTGTIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SGDKVLIHAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLG--VKH MAB_0939|M.abscessus_ATCC_1997 PGDKVLIHAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLG--VKY MSMEG_0408|M.smegmatis_MC2_155 PGDKVLIHAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLG--VKY Mvan_1003|M.vanbaalenii_PYR-1 AGDRVLIHAASGGVGLAAVQLARQRGATVFATASGYKRPMLRAMG--VDH Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PGQRILVHAATGGVGMAAVQLARHWGLEVFATASKGKWDTLRAMGFDEDH MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VYDSRTTDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAE MAB_0939|M.abscessus_ATCC_1997 VYDSRTTDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAE MSMEG_0408|M.smegmatis_MC2_155 VYDSRTTDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAE Mvan_1003|M.vanbaalenii_PYR-1 VYDSRTTDFADQILADTDGAGVDVVLNSLTNDGFVAATVRATARNGRFAE Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 IGDSRSLEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IAKRDIWTVEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRD MAB_0939|M.abscessus_ATCC_1997 IAKRDIWTTEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAK MSMEG_0408|M.smegmatis_MC2_155 IAKRDIWSHEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMAR Mvan_1003|M.vanbaalenii_PYR-1 IAKRDIWSPEQMAAARPDIDYEVLALDAVMQQDPDRIQLLLADLADSLAR Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 MGKTDIREAAVVAQQHTGVRYRAFDLFEAG---PDHIAQILAELAALFSE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GAWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQPDRSYLI MAB_0939|M.abscessus_ATCC_1997 GEWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPRPDRTYLI MSMEG_0408|M.smegmatis_MC2_155 GEWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQQDRSYLI Mvan_1003|M.vanbaalenii_PYR-1 GETAPLPFEAYPLAEATTAFRRMQQARHTGKIILQMPKPLQPHGDRSYLI Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 DVLRPLPVTTFDVRRAPAALRYLSQARHVGKVVLTMPDAWAAG---TVLI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TGGLGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKAR MAB_0939|M.abscessus_ATCC_1997 TGGLGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTR MSMEG_0408|M.smegmatis_MC2_155 TGGLGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCR Mvan_1003|M.vanbaalenii_PYR-1 TGGLGALG-LHAAAYLAQLGAGDIVLTGRRMPDAATERAISEIAERYHCR Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TGGTGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVER MAB_0939|M.abscessus_ATCC_1997 IHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVER MSMEG_0408|M.smegmatis_MC2_155 IHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPER Mvan_1003|M.vanbaalenii_PYR-1 IHTFAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQQSPER Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VQVVACDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVVTSLTPER MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANA MAB_0939|M.abscessus_ATCC_1997 FRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANA MSMEG_0408|M.smegmatis_MC2_155 FRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANA Mvan_1003|M.vanbaalenii_PYR-1 FRTTLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANYATANA Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 IETVLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANISAQG------- MAB_0939|M.abscessus_ATCC_1997 LLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAATANISAQG------- MSMEG_0408|M.smegmatis_MC2_155 MLDGLVAKRRAQGLVATGINFGPWGQGGMASSEAATANITAQG------- Mvan_1003|M.vanbaalenii_PYR-1 VLDGLVAHRKARGLPATGVNWGPWAQGGMATSDAARANLGAQG------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 FLDGLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAM MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -----LIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSSRPPI MAB_0939|M.abscessus_ATCC_1997 -----LIPLDPSAALAALAEVVANGTGQATILKANWQRAAKVLGSSRPPI MSMEG_0408|M.smegmatis_MC2_155 -----LIPLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLGSARPPI Mvan_1003|M.vanbaalenii_PYR-1 -----LIPLEPTAALNALGEIVAHGIASAVVLKANWQRAAKLLGATRPPI Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LDLVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQ MAB_0939|M.abscessus_ATCC_1997 LDLVLPSAVGEVTGDSELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQ MSMEG_0408|M.smegmatis_MC2_155 LDLVLPSAAGEATGDSELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLAS Mvan_1003|M.vanbaalenii_PYR-1 LDHVLPSAVAAGPGDSALLKQLQDVPEAQRGSFVTEHLQRELQQILGLAQ Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PP--AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGG MAB_0939|M.abscessus_ATCC_1997 PP--AATSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGG MSMEG_0408|M.smegmatis_MC2_155 PP--AASSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGG Mvan_1003|M.vanbaalenii_PYR-1 PP--AATGRFLELGMDSLMAVELRNRLVGQFGSGFTITATAVFDYPTIGA Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PDAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LAEYLVAQLPDAETPQAAP-------QSESEPGPDVTE------------ MAB_0939|M.abscessus_ATCC_1997 LAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAASDAVSELKE---- MSMEG_0408|M.smegmatis_MC2_155 LAEYLVGQLPDAEAPETA-------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LAEYLAAQTPESTEEGTEMKTADPDGQPATVGHADVVLQTS--------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LAGYMHRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQAGVLELLL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ----------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 ----------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------------------- Rv1661|M.tuberculosis_H37Rv ----------------------------------------- Mb1689|M.bovis_AF2122/97 ----------------------------------------- MMAR_2471|M.marinum_M ----------------------------------------- MAV_3109|M.avium_104 ----------------------------------------- MUL_2266|M.ulcerans_Agy99 ALANETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE MLBr_00135|M.leprae_Br4923 ----------------------------------------- TH_4621|M.thermoresistible__bu -----------------------------------------