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NEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTGPLSAVGRAAAATVGMALGFLTVFGIFG ALTISAATAVQRYLPYATVLIGLALIALGGWLLLGRGLTALTPRSLGVRWAPTVRLGSMYGYGISYAVAS LSCTIGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALADRLRRILPFVNRISGA LLVVVGLYVGYYGLYELRLIAGVGANPQDAVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTW FRRVRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2877c | - | - | 100% (287) | PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN |
| M. tuberculosis H37Rv | Rv0527 | ccdA | 1e-11 | 29.96% (227) | cytochrome C-type biogenesis protein CcdA |
| M. tuberculosis H37Rv | Rv2874 | dipZ | 3e-06 | 25.36% (209) | integral membrane C-type cytochrome biogenesis protein DipZ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2902c | - | 1e-159 | 99.65% (287) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_3217 | - | 1e-28 | 30.22% (278) | cytochrome c biogenesis protein, transmembrane region |
| M. leprae Br4923 | MLBr_02411 | - | 4e-08 | 26.22% (225) | putative cytochrome C-type biogenesis protein |
| M. abscessus ATCC 19977 | MAB_3244 | - | 1e-72 | 55.83% (240) | mercuric transporter MerT |
| M. marinum M | MMAR_1832 | - | 1e-123 | 75.86% (290) | integral membrane protein |
| M. avium 104 | MAV_3728 | - | 1e-111 | 71.53% (288) | cytochrome C biogenesis protein transmembrane region |
| M. smegmatis MC2 155 | MSMEG_3541 | - | 5e-97 | 65.45% (275) | cytochrome C biogenesis protein transmembrane region |
| M. thermoresistible (build 8) | TH_3805 | - | 3e-69 | 64.73% (207) | PUTATIVE putative NADH-quinone oxidoreductase, L subunit |
| M. ulcerans Agy99 | MUL_2080 | - | 1e-122 | 74.48% (290) | integral membrane protein |
| M. vanbaalenii PYR-1 | Mvan_3693 | - | 9e-13 | 31.80% (217) | cytochrome c biogenesis protein, transmembrane region |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2877c|M.tuberculosis_H37Rv MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDS--AGRTG-PLS
Mb2902c|M.bovis_AF2122/97 MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVHGQDS--AGRTG-PLS
MMAR_1832|M.marinum_M MNSALVALAFAAGSVAALNPCGFAMLPAYLLLVVRGQHGGESGEVGSPIG
MUL_2080|M.ulcerans_Agy99 MNSALVALAFAAGSVAALNPCGFAMLPAYLLLVVRGQHGGESGEAASPIG
MAV_3728|M.avium_104 MDRGLVGLAVAAGMVAALNPCGFAMLPAYLLLVVRG-----AGARAPGVA
TH_3805|M.thermoresistible__bu --------------------------------------------------
MAB_3244|M.abscessus_ATCC_1997 --------------------------------MVRG-----PGAEIGKSQ
MSMEG_3541|M.smegmatis_MC2_155 MEQDLLGLAFGAGLVAALNPCGFALLPGYLALVVRG-----ENAATG-AR
MLBr_02411|M.leprae_Br4923 -----------------------------------------------MTG
Mvan_3693|M.vanbaalenii_PYR-1 -----------------------------------------------MDG
Mflv_3217|M.gilvum_PYR-GCK --MNLLALAFTAGMLAPVNPCGFALLPAWITGTIAT------GGTDAVLV
Rv2877c|M.tuberculosis_H37Rv AVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALI
Mb2902c|M.bovis_AF2122/97 AVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALI
MMAR_1832|M.marinum_M AVGRAIAATIGMALGFLTVFGAFGALTISAASTVQRYLPYLTVLIGVLLF
MUL_2080|M.ulcerans_Agy99 AVGRAIAATIGMALGFLTVFGAFGALTISAASTVQRYLPYLTVSIGVLLF
MAV_3728|M.avium_104 AAGRALAASAGMALGFLTVFGLFGALTVSAAGAVQRWLPYATVVVGVLLV
TH_3805|M.thermoresistible__bu ---------------------------------VQRYLPVATVVVGAGLV
MAB_3244|M.abscessus_ATCC_1997 ALARAVIATVVMAGGFVAVFTVFGLLTVSVASVIQRYLPFVTVVFGIGLV
MSMEG_3541|M.smegmatis_MC2_155 ALGRAALATVAMAAGFVAVFGTFTALTVATASTVQRYLPYVTVVIGLILV
MLBr_02411|M.leprae_Br4923 FTEIAAAGPLLVALGVCMLAGLVSFVSPCVVPLVPGYLSYLAAVVGVSHE
Mvan_3693|M.vanbaalenii_PYR-1 VTAIATSGHVLLAVFVSALAGLVSFASPCVVPLVPGYLSYLAAVVGVDDQ
Mflv_3217|M.gilvum_PYR-GCK RLARALRTGAVLTIGFTGTLTLAGIAISAGARTLVTAAPWLGITIGLTLA
: . .*
Rv2877c|M.tuberculosis_H37Rv ALGGWLLLGRGLTALTPRSLGVR--WAPTVRLGSMYGYGISYAVASLSCT
Mb2902c|M.bovis_AF2122/97 ALGGWLLLGRGLTALTPRSLGVR--WAPTVRLGSMYGYGISYAVASLSCT
MMAR_1832|M.marinum_M GLGVWLLSGRELAALTPSGFGPR--WAPTARLGSMYGYGVSYAVASLSCT
MUL_2080|M.ulcerans_Agy99 GLGVWLLSGRELAALTPSGFGPR--WAPTARLGSMYGYGVSYAVASLSCT
MAV_3728|M.avium_104 ALGGWLLAGRSLSALTPRPVGPL--WAPTARLGSMYGYGISYAIASLSCT
TH_3805|M.thermoresistible__bu ALGFWLLIGRELTGLTSVTRRVE--RAPTARIGSMFGYGVSYAVASLSCT
MAB_3244|M.abscessus_ATCC_1997 ILGLWLLAGRDIIALMPKMLDAN---APTTRLGSMFGYGVGYAVASLSCT
MSMEG_3541|M.smegmatis_MC2_155 CLGIWLLAGRRLGVLMPNSLADNPRWAPTARMGSMLGYGVGYALASLSCT
MLBr_02411|M.leprae_Br4923 ETQPGAGVIKTPPAARWRVAGSAVLFVAGFTTVFVLDTVAVLGMTTVLTT
Mvan_3693|M.vanbaalenii_PYR-1 ARAQPLG------RARLRLAGAAGLFVAGFTAVFLMGTVAILGLTTTLIT
Mflv_3217|M.gilvum_PYR-GCK ILGGFMLTGRTIGLRMPARTRHR---PDSPTAGGVLAAGIGYALASLSCT
: .::: *
Rv2877c|M.tuberculosis_H37Rv IGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALA
Mb2902c|M.bovis_AF2122/97 IGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALA
MMAR_1832|M.marinum_M IGPFIAVTGAGLRGGSILGAVAIYLAYIAGLTMVVGALAIAAATASSALA
MUL_2080|M.ulcerans_Agy99 IGPFIAVTGAGLRGGSILGAVAIYLAYIAGLTMVVGALAIAAATASSALA
MAV_3728|M.avium_104 VGPFLAVTAAGLRSGSLLTGAAVYLGYVAGLTLVVGVLAVAAATAGAATA
TH_3805|M.thermoresistible__bu VAPFLAVTGAGLRGQSLWSTLSIYLAYAAGFTLIVGVLAMAAALTHSALA
MAB_3244|M.abscessus_ATCC_1997 IGPFLAVTSTTFESGSLFDGVMVYLAYASGITLVVGTLAVSTALASTMLL
MSMEG_3541|M.smegmatis_MC2_155 IGPFLAVTGAGLRSGTPLRGVGVFASYAAGFTLVVGVLAVATALARTVVI
MLBr_02411|M.leprae_Br4923 HQVLLQRVGGVLTIVMGLVFVGLLPALQRQVQFSLRQLTTVAGAPVLGTV
Mvan_3693|M.vanbaalenii_PYR-1 NGVLLQRIGGVVTIVMGLVFMGFFPALQRDARFTPTSLSTLWGAPLLGAV
Mflv_3217|M.gilvum_PYR-GCK FGVLLAVIAQAQATSGWGGLLAVFTAYTAGAATILMLVSVGTAIAGTALT
:: . . . :: . .
Rv2877c|M.tuberculosis_H37Rv DRLRRILPFVNRISGALLVVVG--LYVGYYGLYELRLIAGVGANPQDAVI
Mb2902c|M.bovis_AF2122/97 DRLRRILPFVNRISGALLVVVG--LYVGYYGLYELRLIAGVGANPQDAVI
MMAR_1832|M.marinum_M DRLRRVLPLVNRISGGLLVVVG--LYVGYYGYYEVRLTSGLLVDPQDRVI
MUL_2080|M.ulcerans_Agy99 DRLRRVLPLVNRISGGLLAVVG--LYVGYYGYYEVRLTSGLLVDPQDRVI
MAV_3728|M.avium_104 DRLRRMVPFVDRISGAVLVLVG--LYVAYYGGYEVRLFG-AGGDPRDAVI
TH_3805|M.thermoresistible__bu VRLRRIGRYVNRISGVLLVAVG--GYVAYYGLYELRLFW-GGANPQDPVI
MAB_3244|M.abscessus_ATCC_1997 KAMRRALPYLNRVSGAILIVVG--AYVGYYGSYEVRLFH-ANGNPDDPII
MSMEG_3541|M.smegmatis_MC2_155 DRMRRILPYANRISGALLILVG--AYVGYYGLYEVRLFS-GSGDPHDPVI
MLBr_02411|M.leprae_Br4923 FALGWTPCLGPTLSGVITVAAATDGVNVTRGILLVIAYCMGLGIPFVLLA
Mvan_3693|M.vanbaalenii_PYR-1 FGLGWTPCLGPTLTGVIAVASASEGPNVVRGIVLVVAYCVGLGAPFVLFA
Mflv_3217|M.gilvum_PYR-GCK RHLGILARHGTRVTAVVLIATG--AYLAWYWLPAATGHTASGGN------
: ::. : .
Rv2877c|M.tuberculosis_H37Rv AAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTWFR--RVRR----
Mb2902c|M.bovis_AF2122/97 AAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTWFR--RVRR----
MMAR_1832|M.marinum_M GAAGRIQGELAGWVHQHGIWPWAVALTLLVAGAFSVSWYR--RARR----
MUL_2080|M.ulcerans_Agy99 GAAGRIQGELAGWVHQHGIWPWVVVLTLLVAGAFSVSWYR--RARR----
MAV_3728|M.avium_104 GAAGRLQGALAGWVHRHGLWPWALALLALAAVRFGRARRRGRRADRLPDP
TH_3805|M.thermoresistible__bu EAAARAQGAIAGWVHRHGGGPWLAATAVLMLVVLATGFVA--RIRRSARR
MAB_3244|M.abscessus_ATCC_1997 NAAGKIQRTISGWVYLHGAWPWLFILGLVAVGAAIWWRTNVSEPPSN---
MSMEG_3541|M.smegmatis_MC2_155 AAAGKIQGTLAGWVHQHGALPWAIGL-LVLIGLGLLWRVRIFARRSPARR
MLBr_02411|M.leprae_Br4923 SGSAQAVAGLR-WLRQYGRAIQVFGGMLLIAIGAALIAGVWDDFVSWLRD
Mvan_3693|M.vanbaalenii_PYR-1 LASGRAMRALG-WLRRNARRIQVFGGVLLVAVGIALVTGLWNEVVSWVRD
Mflv_3217|M.gilvum_PYR-GCK -LLTGWSATATGWLQDHALPASVIAAFAVVVSAVAAYWTTHRRPITGKQR
*: . :
Rv2877c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2902c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1832|M.marinum_M --------------------------------------------------
MUL_2080|M.ulcerans_Agy99 --------------------------------------------------
MAV_3728|M.avium_104 AAAAAPQVADQHHEDQRRESDQKPVLDVADVVAAQHGQQQPEDDQADDVP
TH_3805|M.thermoresistible__bu --------------------------------------------------
MAB_3244|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3541|M.smegmatis_MC2_155 ATADDAP-------------------------------------------
MLBr_02411|M.leprae_Br4923 AVVSDMRVSI----------------------------------------
Mvan_3693|M.vanbaalenii_PYR-1 AFVSNTTLPI----------------------------------------
Mflv_3217|M.gilvum_PYR-GCK RR------------------------------------------------
Rv2877c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2902c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1832|M.marinum_M --------------------------------------------------
MUL_2080|M.ulcerans_Agy99 --------------------------------------------------
MAV_3728|M.avium_104 GPVVDPAPSPRRRRHLDGVDAGEVLDLGTGHGESPSDRIGLSNPDSGTTA
TH_3805|M.thermoresistible__bu --------------------------------------------------
MAB_3244|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_3541|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02411|M.leprae_Br4923 --------------------------------------------------
Mvan_3693|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3217|M.gilvum_PYR-GCK --------------------------------------------------
Rv2877c|M.tuberculosis_H37Rv -------------------
Mb2902c|M.bovis_AF2122/97 -------------------
MMAR_1832|M.marinum_M -------------------
MUL_2080|M.ulcerans_Agy99 -------------------
MAV_3728|M.avium_104 GRARGARPHHGPRRWRAAQ
TH_3805|M.thermoresistible__bu -------------------
MAB_3244|M.abscessus_ATCC_1997 -------------------
MSMEG_3541|M.smegmatis_MC2_155 -------------------
MLBr_02411|M.leprae_Br4923 -------------------
Mvan_3693|M.vanbaalenii_PYR-1 -------------------
Mflv_3217|M.gilvum_PYR-GCK -------------------