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VLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAADPALATVVSRANRSHLIHFATANLRK PGQPVPANLGPDPLRMARDLVRRGLDASALDVYRVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSAS EFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPD DNQNHLDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDG FRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASPQLLTTVLTYIN EQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPP PESLGRRRSRLAQLER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2370c | - | - | 100% (437) | hypothetical protein Rv2370c |
| M. tuberculosis H37Rv | Rv1453 | - | e-167 | 69.68% (409) | transcriptional activator protein |
| M. tuberculosis H37Rv | Rv1194c | - | e-151 | 63.70% (405) | hypothetical protein Rv1194c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2391c | - | 0.0 | 100.00% (437) | hypothetical protein Mb2391c |
| M. gilvum PYR-GCK | Mflv_4621 | - | 3e-11 | 23.41% (346) | hypothetical protein Mflv_4621 |
| M. leprae Br4923 | MLBr_01052 | - | 1e-147 | 61.19% (402) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 6e-65 | 36.27% (397) | hypothetical protein MAB_2657c |
| M. marinum M | MMAR_2258 | - | 1e-155 | 66.25% (403) | transcriptional activator protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1456 | - | 2e-08 | 34.45% (119) | hypothetical protein MSMEG_1456 |
| M. thermoresistible (build 8) | TH_2938 | - | 5e-22 | 28.61% (353) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_0944 | - | 1e-145 | 62.41% (399) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 4e-06 | 25.65% (191) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4621|M.gilvum_PYR-GCK ---------------------MLDSSEVQDTPGHAVHHLFRDLGDLVRE-
TH_2938|M.thermoresistible__bu ----------------------------------------------VGY-
Rv2370c|M.tuberculosis_H37Rv ----------------------MVLPKPTPRGRELIRQAAKVALHPTPE-
Mb2391c|M.bovis_AF2122/97 ----------------------MVLPKPTPRGRELIRQAAKVALHPTPE-
MMAR_2258|M.marinum_M ----------------------MKSRELSPRVRDLIREAARVALNPSQQ-
MLBr_01052|M.leprae_Br4923 ----------------------MARQHPSPRVRELIREGARIALNPTQE-
MUL_0944|M.ulcerans_Agy99 ----------------------MPWQRPSSRIRELIREGARRALNAGPE-
MAB_2657c|M.abscessus_ATCC_199 ------MNEGSERVHTQSMTPDQLWPDASEPVRRLIRELAEKMLARSGE-
Mvan_5765|M.vanbaalenii_PYR-1 MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVLDRVARTACTLLGYD
MSMEG_1456|M.smegmatis_MC2_155 ------MTAPPIDSGRMTVRGLLDESLMAGSRIVAGEDLLDEELTWVLPL
Mflv_4621|M.gilvum_PYR-GCK -----LPESIHGLLIEQV----------AELAADQQLKELLSDTVAAN--
TH_2938|M.thermoresistible__bu -----GPGSRQG-------------------SGCRQLLELLRDSVEGN--
Rv2370c|M.tuberculosis_H37Rv -----WLDELDRATLAAH----------PSIAADPALATVVSRANRSH--
Mb2391c|M.bovis_AF2122/97 -----WLDELDRATLAAH----------PSIAADPALATVVSRANRSH--
MMAR_2258|M.marinum_M -----WLEEFDRATLAAA----------PPIAENPDLATVISRANRAN--
MLBr_01052|M.leprae_Br4923 -----WIDQLDRATFAAN----------PAIANDPVLAKVVRRASRAH--
MUL_0944|M.ulcerans_Agy99 -----WIEELDRETVSAN----------PTIANDPVLAKVVKRVNRAN--
MAB_2657c|M.abscessus_ATCC_199 -----VAGDLTAASLEDPRY--------RTIADDPVIAEVDARLTVSN--
Mvan_5765|M.vanbaalenii_PYR-1 FCAVFLPDEQGRALTIEGSYGLSADYIAQVNANRPILLDVRGDHEAPTSL
MSMEG_1456|M.smegmatis_MC2_155 NEVLSQHDRLDAVAVYARPE--------SLTARASTLSALAARGATTLLV
: : :
Mflv_4621|M.gilvum_PYR-GCK -----------------------------VDTWFSV-VRHSIPFDRMESP
TH_2938|M.thermoresistible__bu -----------------------------IDTIFSA-IQHDIPIEEVAPP
Rv2370c|M.tuberculosis_H37Rv -----------------------------LIHFATANLRKPGQPVPANLG
Mb2391c|M.bovis_AF2122/97 -----------------------------LIHFATANLRKPGQPVPANLG
MMAR_2258|M.marinum_M -----------------------------LRHFAASNLRNPGDPVPANLG
MLBr_01052|M.leprae_Br4923 -----------------------------LVHWATANLRDPGAPVPAHLG
MUL_0944|M.ulcerans_Agy99 -----------------------------LVHWAAANVRHPGAPVPANLG
MAB_2657c|M.abscessus_ATCC_199 -----------------------------LKHWLTSNISEPGHRVRPATG
Mvan_5765|M.vanbaalenii_PYR-1 AYRTGDVVTLEDIELVPDFTWGGVAQEQGYRALISAPLRRPGTVVGALNG
MSMEG_1456|M.smegmatis_MC2_155 DGVAPPDLG------------------GLPAGLVVVELGIPVGFAALNRL
:
Mflv_4621|M.gilvum_PYR-GCK TAALEHARRMAQREVPVNALLRAYRLGHQ-YGLNLIIAGLRSADLPPEEK
TH_2938|M.thermoresistible__bu TAALEYARRLARHGVEPHALLRAYRLGQQ-KLLDIVLHEIRSLDWEREVS
Rv2370c|M.tuberculosis_H37Rv PDPLRMARDLVRRGLDASALD-VYRVGQN-VAWQRWTEIAFGLTTDPQEL
Mb2391c|M.bovis_AF2122/97 PDPLRMARDLVRRGLDASALD-VYRVGQN-VAWQRWTEIAFGLTTDPQEL
MMAR_2258|M.marinum_M AEPLRMARDLVRLGLDTLALD-VYRVGQN-VAWQRWTDIVFGLTTDPQEL
MLBr_01052|M.leprae_Br4923 PEPLTMARDLVRRGRDVLALD-IYRVGQY-TAWRRWMEIAFTLTSDPQEL
MUL_0944|M.ulcerans_Agy99 GEPLRMARDLVRRGLEALTLD-IYRIGQY-IAWRLWINIAFDLTSDPQEL
MAB_2657c|M.abscessus_ATCC_199 SAMRTYARDVVLRGLTTDDIQ-SWRAVQR-VGWKWWLAACFQVTDDKEQL
Mvan_5765|M.vanbaalenii_PYR-1 YRTAPHRFDRAEVSLVTTLATQVAIALGT-AQLRAKEQATIRELRRAEEV
MSMEG_1456|M.smegmatis_MC2_155 LAERALSQEVHVMRYSTHVHATLAGLFHRGAGLQILVREVSNLARNPAVA
Mflv_4621|M.gilvum_PYR-GCK LALIEHITR------VSFRYIDWMSEQVLETYQTERAEWDE---------
TH_2938|M.thermoresistible__bu LEFVVGVTN------ATFGYIDGISQRVVEVYQQERERWLE---------
Rv2370c|M.tuberculosis_H37Rv HELLTLPFR------SASEFIDATLAGLAAQMQLEYDELTR---------
Mb2391c|M.bovis_AF2122/97 HELLTLPFR------SASEFIDATLAGLAAQMQLEYDELTR---------
MMAR_2258|M.marinum_M RELLDVPFR------SAAAFIDTTLAGIAAQMELEHHELSR---------
MLBr_01052|M.leprae_Br4923 REILNVSAQ------SINEYVAATLEAIATHMQLERDELTR---------
MUL_0944|M.ulcerans_Agy99 HELLDVSAK------SVNEFIEATLAGIAAQVQLEHDELTR---------
MAB_2657c|M.abscessus_ATCC_199 CELIEVTSN------SLTTFVDDSIAELAEHVRRVREELAG---------
Mvan_5765|M.vanbaalenii_PYR-1 HTLLTATALRG----EGVSGVAAALSELLGRGVLIEDVYDEPLTDANWTA
MSMEG_1456|M.smegmatis_MC2_155 LDARGHVVAHHGLPPEAVAALADSVSRMLAADLPASERRHDGHDTRTQQV
: :
Mflv_4621|M.gilvum_PYR-GCK -RRRSLRAQAIRDILNG------------RDVDLTEASSAMR----YFLG
TH_2938|M.thermoresistible__bu -NRNSLRAMRVRELLDG------------GEVDVDTASATVG----YPLR
Rv2370c|M.tuberculosis_H37Rv -DVHAEHRRIVELILDG------------APISRQSAEAKLG----YPLD
Mb2391c|M.bovis_AF2122/97 -DVHAEHRRIVELILDG------------APISRQSAEAKLG----YPLD
MMAR_2258|M.marinum_M -NICAERRRIVELLLNG------------APISRDSAESRLG----YPLD
MLBr_01052|M.leprae_Br4923 -STHAERLEVVDLILEG------------APVTQERAEARLG----YRLG
MUL_0944|M.ulcerans_Agy99 -GNHADRLEVVGHLLEG------------APISRERAETRLG----YSLI
MAB_2657c|M.abscessus_ATCC_199 -GSQLQRYATVELLLQG------------ADIAPARAEAQLG----YALT
Mvan_5765|M.vanbaalenii_PYR-1 PDPRAQDHVVATVTLDG------------SPVARIHVAASDSELSRLDVR
MSMEG_1456|M.smegmatis_MC2_155 TGPEDSRWTCVASAIRLGKSFEGWVAVLVPTLAPDHADGPSKHDLARHEV
: : .
Mflv_4621|M.gilvum_PYR-GCK ATHVALMVWLDRDAGADTDEFIAMERFMQHAVSATGAK-QSVYFSIDRLV
TH_2938|M.thermoresistible__bu RTHLAVCVWTP-DGSAGDNELDRLQRYVRGLAEALGAPGDSLFIALDRLT
Rv2370c|M.tuberculosis_H37Rv RSHTAAIIWYDDPDDNQN----HLDHTARAFGRALGCP-QPLIAVASAAT
Mb2391c|M.bovis_AF2122/97 RSHTAAIIWYDDPDDNQN----HLDHTARAFGRALGCP-QPLIAVASAAT
MMAR_2258|M.marinum_M RSHTAAIIWSDRSDGDHR----DLDRAVDAFCNAVGCA-SSLAIMSAATT
MLBr_01052|M.leprae_Br4923 LTHTAAVIWSDDLDGDHG----YLDQAAEAFSHVVEST-QQLIVVASAAT
MUL_0944|M.ulcerans_Agy99 RAHTAAIIWSDDFDGDHS----NLDRAADAFCHAVGSS-QDLTVVANAAT
MAB_2657c|M.abscessus_ATCC_199 GSHIGAVVWVDS-EKEIA----ALERASEQVMRACGAD-RRLTVVAGTVA
Mvan_5765|M.vanbaalenii_PYR-1 AVEHATVVTALELLRARTAAEVEQRIRGSLVADLLSSDDAGIPALLDRAR
MSMEG_1456|M.smegmatis_MC2_155 LTEQATAIIGSEMLRQRSVDEAEERARGDFVQALVHGSFSSEHDMRARAE
. . :
Mflv_4621|M.gilvum_PYR-GCK GCAW--------------MTVH--RPSDYLSQLRDFVRAQPDGPRLSVG-
TH_2938|M.thermoresistible__bu GCGW--------------IPLPGDAATGAVAGVRRYAAEHPDGPHLALG-
Rv2370c|M.tuberculosis_H37Rv RWVW--------------VSDAATLDTDRIHQVLDHAPH----ARIAVG-
Mb2391c|M.bovis_AF2122/97 RWVW--------------VSDAATLDTDRIHQVLDHAPH----ARIAVG-
MMAR_2258|M.marinum_M RWVW--------------VRDVDVFDCSRIRQVMRELPH----VRIAIG-
MLBr_01052|M.leprae_Br4923 RWVW--------------LADALALDVPEVQKALLNLSK----ARVAIG-
MUL_0944|M.ulcerans_Agy99 RWVW--------------LAEATNLDIDTIEQAVDNASD----ARIAIG-
MAB_2657c|M.abscessus_ATCC_199 LWLW--------------IPAKTTPTVAVLMDSLGRRSG----VRVALG-
Mvan_5765|M.vanbaalenii_PYR-1 RLGWDLSGVQ-------SLIALRPADERTLAAADRFTAGVTPHPLVALHR
MSMEG_1456|M.smegmatis_MC2_155 HHDIELDARFGVFVAPGVLPRGPDSPTTPMVRLARYAAGVAAHPSVHAYV
: : :
Mflv_4621|M.gilvum_PYR-GCK ----------------------------------EPLPGIEGFRR-----
TH_2938|M.thermoresistible__bu ----------------------------------DPLPGLDGFRR-----
Rv2370c|M.tuberculosis_H37Rv ----------------------------------TTARGIDGFRR-----
Mb2391c|M.bovis_AF2122/97 ----------------------------------TTARGIDGFRR-----
MMAR_2258|M.marinum_M ----------------------------------TTEPGVDGFRR-----
MLBr_01052|M.leprae_Br4923 ----------------------------------TSSAGIEGFRR-----
MUL_0944|M.ulcerans_Agy99 ----------------------------------TKASGIEGFRR-----
MAB_2657c|M.abscessus_ATCC_199 ----------------------------------RAATGMAGFRR-----
Mvan_5765|M.vanbaalenii_PYR-1 GDLVFVWPADTGPAVPVAHRLLEFLNAATIPEAPTAAVSRQAAAR-----
MSMEG_1456|M.smegmatis_MC2_155 TVIG-----DVLVVVRTLRGEDAAAMRSEMAEYAEAMSGELQRRRGLPAP
. *
Mflv_4621|M.gilvum_PYR-GCK -----------TYRQAEQARVVAVAADGSSRHRIVAARDP-GVALASMLM
TH_2938|M.thermoresistible__bu -----------SYRQALRTRAVAVAA-GASAPRVTAAADP-GLSAAALLT
Rv2370c|M.tuberculosis_H37Rv -----------SHRDALATQRMLARLRSQQR----LAFFA-DIHMIAVLT
Mb2391c|M.bovis_AF2122/97 -----------SHRDALATQRMLARLRSQQR----LAFFA-DIHMIAVLT
MMAR_2258|M.marinum_M -----------SHRDALTAARMLIRLRSPQQ----VAFFG-DVEMIALLT
MLBr_01052|M.leprae_Br4923 -----------SHLEALTAQRTLARLKSHQQ----VAFFA-DVQLVSLIT
MUL_0944|M.ulcerans_Agy99 -----------SHLEALTTQRTLARLKSDQR----VAFFS-DVQIVALIT
MAB_2657c|M.abscessus_ATCC_199 -----------THMDAAAAQRLLARLGSPLS----VVRYE-DVHLMDLLS
Mvan_5765|M.vanbaalenii_PYR-1 -----------ELPGIFRTVRGALDLAGDRDTATVIDLDEPTIDHLLLQL
MSMEG_1456|M.smegmatis_MC2_155 VAYGRPALGAGEVRESYREARVALGIARRLHRTGATSYQQLRGFTVLAQV
Mflv_4621|M.gilvum_PYR-GCK TDDATLKEWIHDVLG-PLAQNTASDQRLRDTLRVFLRAGSSFKAAANELQ
TH_2938|M.thermoresistible__bu GDLAEARTWVQEVLG-PLSADTKNDARLRETLGVFLRHGSSYTAAADELN
Rv2370c|M.tuberculosis_H37Rv ENPDSAADFITSTLG-DLESASP---QLLTTVLTYINEQCNASRAAHVLH
Mb2391c|M.bovis_AF2122/97 ENPDSAADFITSTLG-DLESASP---QLLTTVLTYINEQCNASRAAHVLH
MMAR_2258|M.marinum_M ENPDGADEFIKNTLG-DFEEASP---ALQHTLLTFISQQCNASRAARLLY
MLBr_01052|M.leprae_Br4923 QNPEDAKEFITSTLG-DFESASP---ALQQTLLTFINEQCNASRAAKRLF
MUL_0944|M.ulcerans_Agy99 QNTQAANEFITSTLG-ELESAAP---ELQATLLMFINEQCNASRAAKRLY
MAB_2657c|M.abscessus_ATCC_199 ADPASADQFVTDVLG-EFQSASP---VLHQTVLTYVEEALNRTSTAERLY
Mvan_5765|M.vanbaalenii_PYR-1 DDPARLRDFASAVLGPAVDYDRTRSTELLHTVRVLLEHGLDRRAAAQALH
MSMEG_1456|M.smegmatis_MC2_155 AETEDSRQLVRDVLG-PLRSSPD----LLETLEAYLSEGGNINATARTLN
: .** . * *: : . :* *
Mflv_4621|M.gilvum_PYR-GCK IHANTVKYRVNRALERRGRPIAAERLDVEVALLMCYWLGEVALNPTQALG
TH_2938|M.thermoresistible__bu LHFNTVKYRVQRAVERRGRPIVPDRLDVELALLICQWFGAAVLRPQR---
Rv2370c|M.tuberculosis_H37Rv THRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPV
Mb2391c|M.bovis_AF2122/97 THRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPV
MMAR_2258|M.marinum_M THRNTLMHRLETAQRLLPKPLEDTTVRVAVALEVLQWRSKQPGNPAAS--
MLBr_01052|M.leprae_Br4923 THRNTLLRRIESAEKLLPRPLDHTSVHIAVALEALQWRGDQTNTSGPR--
MUL_0944|M.ulcerans_Agy99 THRNTLLRRIEAAQRLLPRPLAHTSVHVAVALEALQWRGDNIAKLPTP--
MAB_2657c|M.abscessus_ATCC_199 THRNTIDRRLARVDELLPKPFARNPIEVAAALTLLRVRAGR---------
Mvan_5765|M.vanbaalenii_PYR-1 LHPNTVAQRVRRLEELTGLSLARPADLLRLTAALTVSRIASLS-------
MSMEG_1456|M.smegmatis_MC2_155 VHRNTMLAKLDRISRMLGMDVRDPEHQFTVWLAIRLDLLDEVHSAVEREA
* **: :: . . .
Mflv_4621|M.gilvum_PYR-GCK RS---------------------
TH_2938|M.thermoresistible__bu -----------------------
Rv2370c|M.tuberculosis_H37Rv EGITSPPPESLGRRRSRLAQLER
Mb2391c|M.bovis_AF2122/97 EGITSPPPESLGRRRSRLAQLER
MMAR_2258|M.marinum_M -GAGKPDDRTPPEQRP-------
MLBr_01052|M.leprae_Br4923 ---AGRNDGVPA-----------
MUL_0944|M.ulcerans_Agy99 ---TSQDDEVPA-----------
MAB_2657c|M.abscessus_ATCC_199 -----------------------
Mvan_5765|M.vanbaalenii_PYR-1 -----------------------
MSMEG_1456|M.smegmatis_MC2_155 SFR--------------------