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VKSRELSPRVRDLIREAARVALNPSQQWLEEFDRATLAAAPPIAENPDLATVISRANRANLRHFAASNLR NPGDPVPANLGAEPLRMARDLVRLGLDTLALDVYRVGQNVAWQRWTDIVFGLTTDPQELRELLDVPFRSA AAFIDTTLAGIAAQMELEHHELSRNICAERRRIVELLLNGAPISRDSAESRLGYPLDRSHTAAIIWSDRS DGDHRDLDRAVDAFCNAVGCASSLAIMSAATTRWVWVRDVDVFDCSRIRQVMRELPHVRIAIGTTEPGVD GFRRSHRDALTAARMLIRLRSPQQVAFFGDVEMIALLTENPDGADEFIKNTLGDFEEASPALQHTLLTFI SQQCNASRAARLLYTHRNTLMHRLETAQRLLPKPLEDTTVRVAVALEVLQWRSKQPGNPAASGAGKPDDR TPPEQRP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2258 | - | - | 100% (427) | transcriptional activator protein |
| M. marinum M | MMAR_2099 | - | e-143 | 59.65% (399) | transcriptional regulator |
| M. marinum M | MMAR_4242 | - | e-140 | 61.87% (396) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1488 | - | 1e-169 | 69.34% (411) | transcriptional activator protein |
| M. gilvum PYR-GCK | Mflv_4621 | - | 3e-16 | 24.54% (326) | hypothetical protein Mflv_4621 |
| M. tuberculosis H37Rv | Rv1453 | - | 1e-169 | 69.10% (411) | transcriptional activator protein |
| M. leprae Br4923 | MLBr_01052 | - | 1e-137 | 57.04% (412) | hypothetical protein MLBr_01052 |
| M. abscessus ATCC 19977 | MAB_2657c | - | 6e-64 | 35.41% (401) | hypothetical protein MAB_2657c |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1456 | - | 3e-07 | 30.87% (149) | hypothetical protein MSMEG_1456 |
| M. thermoresistible (build 8) | TH_3143 | - | 3e-23 | 27.30% (392) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1854 | - | 0.0 | 98.21% (336) | transcriptional activator protein |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2258|M.marinum_M ---------------------MKSRELSP-------------RVRDLIRE
MUL_1854|M.ulcerans_Agy99 ---------------------MKSRELSP-------------RVRDLIRE
Mb1488|M.bovis_AF2122/97 ---------------------MALRETSP-------------RIHELIRE
Rv1453|M.tuberculosis_H37Rv ---------------------MALRETSP-------------RIHELIRE
MLBr_01052|M.leprae_Br4923 ---------------------MARQHPSP-------------RVRELIRE
MAB_2657c|M.abscessus_ATCC_199 -----MNEGSERVHTQSMTPDQLWPDASE-------------PVRRLIRE
Mflv_4621|M.gilvum_PYR-GCK --------------------MLDSSEVQD-------------TPGHAVHH
TH_3143|M.thermoresistible__bu --------------------VVVSGYNAD-------------DISSTVAL
MSMEG_1456|M.smegmatis_MC2_155 MTAPPIDSGRMTVRGLLDESLMAGSRIVAGEDLLDEELTWVLPLNEVLSQ
:
MMAR_2258|M.marinum_M AARVALNPSQQWLEEFDRATLAAA--PPIAENPDLATVISRANRANLRH-
MUL_1854|M.ulcerans_Agy99 AARVALNPSQQWLEEFDRATLATA--PPIAENPDLATVISRANRANLRH-
Mb1488|M.bovis_AF2122/97 AARIALNPTQEWLDEFDRAILAAN--PSIAADPALATVVKRSNRAHLIH-
Rv1453|M.tuberculosis_H37Rv AARIALNPTQEWLDEFDRAILAAN--PSIAADPALATVVKRSNRAHLIH-
MLBr_01052|M.leprae_Br4923 GARIALNPTQEWIDQLDRATFAAN--PAIANDPVLAKVVRRASRAHLVH-
MAB_2657c|M.abscessus_ATCC_199 LAEKMLARSGEVAGDLTAASLEDPRYRTIADDPVIAEVDARLTVSNLKH-
Mflv_4621|M.gilvum_PYR-GCK LFRDLGDLVRELPESIHGLLIEQV--AELAADQQLKELLSDTVAANVDT-
TH_3143|M.thermoresistible__bu IVDRLLENSGEDVERIQRRILADI--DELRSDPRLVELLRSSVAGNVET-
MSMEG_1456|M.smegmatis_MC2_155 HDRLDAVAVYARPESLTARASTLSALAARGATTLLVDGVAPPDLGGLPAG
: : . :
MMAR_2258|M.marinum_M --FAASNLRNPGDPVPANLGAEPLRMARDLVRLGLDTLALD--VYRVGQ-
MUL_1854|M.ulcerans_Agy99 --FAASNLRNPGDPVPANLGAEPLRMARDLVRLGLDTLALD--VYRVGQ-
Mb1488|M.bovis_AF2122/97 --FAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALD--IYRIGQ-
Rv1453|M.tuberculosis_H37Rv --FAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALD--IYRIGQ-
MLBr_01052|M.leprae_Br4923 --WATANLRDPGAPVPAHLGPEPLTMARDLVRRGRDVLALD--IYRVGQ-
MAB_2657c|M.abscessus_ATCC_199 --WLTSNISEPGHRVRPATGSAMRTYARDVVLRGLTTDDIQ--SWRAVQ-
Mflv_4621|M.gilvum_PYR-GCK --WFSV-VRHSIPFDRMESPTAALEHARRMAQREVPVNALLR-AYRLGH-
TH_3143|M.thermoresistible__bu --VLTV-IRYGIDLDRVEPPTAALEYARRAAQHGIALSALIR-AYRLGQ-
MSMEG_1456|M.smegmatis_MC2_155 LVVVELGIPVGFAALNRLLAERALSQEVHVMRYSTHVHATLAGLFHRGAG
: ::
MMAR_2258|M.marinum_M ---------------NVAWQRWTDIVFGLTTDPQELRELLDVPFRSAAAF
MUL_1854|M.ulcerans_Agy99 ---------------NVAWQRWTDIVFGLTTDPQELRELLDVPFRSAVAF
Mb1488|M.bovis_AF2122/97 ---------------NVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEF
Rv1453|M.tuberculosis_H37Rv ---------------NVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEF
MLBr_01052|M.leprae_Br4923 ---------------YTAWRRWMEIAFTLTSDPQELREILNVSAQSINEY
MAB_2657c|M.abscessus_ATCC_199 ---------------RVGWKWWLAACFQVTDDKEQLCELIEVTSNSLTTF
Mflv_4621|M.gilvum_PYR-GCK ---------------QYGLNLIIAGLRSADLPPEEKLALIEHITRVSFRY
TH_3143|M.thermoresistible__bu ---------------QEMLERILREVRETELDPDLRLSVYERISSTSFAY
MSMEG_1456|M.smegmatis_MC2_155 LQILVREVSNLARNPAVALDARGHVVAHHGLPPEAVAALADSVSRMLAAD
: : :
MMAR_2258|M.marinum_M IDTT----------------------------------------------
MUL_1854|M.ulcerans_Agy99 IDTT----------------------------------------------
Mb1488|M.bovis_AF2122/97 VDTT----------------------------------------------
Rv1453|M.tuberculosis_H37Rv VDTT----------------------------------------------
MLBr_01052|M.leprae_Br4923 VAAT----------------------------------------------
MAB_2657c|M.abscessus_ATCC_199 VDDS----------------------------------------------
Mflv_4621|M.gilvum_PYR-GCK IDWM----------------------------------------------
TH_3143|M.thermoresistible__bu IDWI----------------------------------------------
MSMEG_1456|M.smegmatis_MC2_155 LPASERRHDGHDTRTQQVTGPEDSRWTCVASAIRLGKSFEGWVAVLVPTL
:
MMAR_2258|M.marinum_M ----------------------LAGIAAQMELEHHELSRNICAERRRIVE
MUL_1854|M.ulcerans_Agy99 ----------------------LAGIAAQMELEHHELSRNICAERRRIVE
Mb1488|M.bovis_AF2122/97 ----------------------LAGITTEMQLERDKLTRDVPAERRKIVQ
Rv1453|M.tuberculosis_H37Rv ----------------------LAGITTEMQLERDKLTRDVPAERRKIVQ
MLBr_01052|M.leprae_Br4923 ----------------------LEAIATHMQLERDELTRSTHAERLEVVD
MAB_2657c|M.abscessus_ATCC_199 ----------------------IAELAEHVRRVREELAGGSQLQRYATVE
Mflv_4621|M.gilvum_PYR-GCK ----------------------SEQVLETYQTERAEWDERRRSLRAQAIR
TH_3143|M.thermoresistible__bu ----------------------SQQVSDTYDTERERWLEHRNNIRAVRVR
MSMEG_1456|M.smegmatis_MC2_155 APDHADGPSKHDLARHEVLTEQATAIIGSEMLRQRSVDEAEERARGDFVQ
: : * :
MMAR_2258|M.marinum_M LLLNGAP-ISRDSAESRLGYPLDRSHTAAIIWSDR----SDGDHRDLDRA
MUL_1854|M.ulcerans_Agy99 LLLNGAP-ISRDSAESRLGYPLDRSHTAAIIWSDR----PNGDHRDLDRA
Mb1488|M.bovis_AF2122/97 LLIDGAP-ISREHAEARLGYPLDRSHTAAVIWGDQ----AQGDHSHLDRV
Rv1453|M.tuberculosis_H37Rv LLIDGAP-ISREHAEARLGYPLDRSHTAAVIWGDQ----AQGDHSHLDRV
MLBr_01052|M.leprae_Br4923 LILEGAP-VTQERAEARLGYRLGLTHTAAVIWSDD----LDGDHGYLDQA
MAB_2657c|M.abscessus_ATCC_199 LLLQGAD-IAPARAEAQLGYALTGSHIGAVVWVD-----SEKEIAALERA
Mflv_4621|M.gilvum_PYR-GCK DILNGRD-VDLTEASSAMRYFLGATHVALMVWLDRDAGADTDEFIAMERF
TH_3143|M.thermoresistible__bu EILDSDEPIDIDTASAALGYPLRGRHLALVLWMTR-SDLPGGELLRLERF
MSMEG_1456|M.smegmatis_MC2_155 ALVHGSFSSEHDMRARAEHHDIELDARFGVFVAPG--VLPRGPDSPTTPM
::.. : : :.
MMAR_2258|M.marinum_M VDAFCNAVGCASSLAIMSAATTR---WVWVRDVDVFDCSRIR--------
MUL_1854|M.ulcerans_Agy99 VDAFCNAVGCASSLAIMSAATTR---WVWVRDVDVFDCSHIR--------
Mb1488|M.bovis_AF2122/97 ADAFGHAGGCPHPLVVVAGAATR---WVWVKDAPGFDIDLIH--------
Rv1453|M.tuberculosis_H37Rv ADAFGHAGGCPHPLVVVAGAATR---WVWVKDAPGFDIDLIH--------
MLBr_01052|M.leprae_Br4923 AEAFSHVVESTQQLIVVASAATR---WVWLADALALDVPEVQ--------
MAB_2657c|M.abscessus_ATCC_199 SEQVMRACGADRRLTVVAGTVAL---WLWIPAKTTPTVAVLM--------
Mflv_4621|M.gilvum_PYR-GCK MQHAVSATGAKQS-VYFSIDRLVGCAWMTV-HRPSDYLSQLR--------
TH_3143|M.thermoresistible__bu ARAVAEAFQLRNTPLFVAEDTVSGWAWLAINHVVTEPVRTIR--------
MSMEG_1456|M.smegmatis_MC2_155 VRLARYAAGVAAHPSVHAYVTVIGDVLVVVRTLRGEDAAAMRSEMAEYAE
. : : : :
MMAR_2258|M.marinum_M ----QVMRELP-HVRIAIGTTEPGVDGFRRSHRDALTAARMLIRLR--SP
MUL_1854|M.ulcerans_Agy99 ----QVMRELP-HVRIAIGTTEPGVDGFRRSRRDALTAARMLIRLR--SP
Mb1488|M.bovis_AF2122/97 ----EVLHDIP-DARIAIGATAPGIEGFRRSHRDALTTARMIIRLE--SP
Rv1453|M.tuberculosis_H37Rv ----EVLHDIP-DARIAIGATAPGIEGFRRSHRDALTTARMIIRLE--SP
MLBr_01052|M.leprae_Br4923 ----KALLNLS-KARVAIGTSSAGIEGFRRSHLEALTAQRTLARLK--SH
MAB_2657c|M.abscessus_ATCC_199 ----DSLGRRS-GVRVALGRAATGMAGFRRTHMDAAAAQRLLARLG--SP
Mflv_4621|M.gilvum_PYR-GCK ----DFVRAQPDGPRLSVGEPLPGIEGFRRTYRQAEQARVVAVAADGSSR
TH_3143|M.thermoresistible__bu ----ELAETADNGVHVALGTVDDGLEGFRRSHRRARDARKVAAAS--AIP
MSMEG_1456|M.smegmatis_MC2_155 AMSGELQRRRGLPAPVAYGRPALGAGEVRESYREARVALGIARRLHRTGA
. :: * * .*.: * :
MMAR_2258|M.marinum_M QQVAFFGD--VEMIALLTENPDGADEFIKNTLGDFEEASP---ALQHTLL
MUL_1854|M.ulcerans_Agy99 QQVAFFGD--VEMIALLTENPDGADEFIKNTLGDFE--------------
Mb1488|M.bovis_AF2122/97 HRVAFFTD--VEMVALLTENAEGADDFIQRTLGNLESASP---ALKTTLL
Rv1453|M.tuberculosis_H37Rv HRVAFFTD--VEMVALLTENAEGADDFIQRTLGNLESASP---ALKTTLL
MLBr_01052|M.leprae_Br4923 QQVAFFAD--VQLVSLITQNPEDAKEFITSTLGDFESASP---ALQQTLL
MAB_2657c|M.abscessus_ATCC_199 LSVVRYED--VHLMDLLSADPASADQFVTDVLGEFQSASP---VLHQTVL
Mflv_4621|M.gilvum_PYR-GCK HRIVAARDPGVALASMLMTDDATLKEWIHDVLGPLAQNTASDQRLRDTLR
TH_3143|M.thermoresistible__bu PRITAADDYGISVSALLTENLADTRRWVLDTLGPLASDTANDARLRETLL
MSMEG_1456|M.smegmatis_MC2_155 TSYQQLRG---FTVLAQVAETEDSRQLVRDVLGPLRSSPD----LLETLE
. : : .** :
MMAR_2258|M.marinum_M TFISQQCNASRAARLLYTHRNTLMHRLETAQRLLPKPLEDTTVRVAVALE
MUL_1854|M.ulcerans_Agy99 --------------------------------------------------
Mb1488|M.bovis_AF2122/97 TFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALE
Rv1453|M.tuberculosis_H37Rv TFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALE
MLBr_01052|M.leprae_Br4923 TFINEQCNASRAAKRLFTHRNTLLRRIESAEKLLPRPLDHTSVHIAVALE
MAB_2657c|M.abscessus_ATCC_199 TYVEEALNRTSTAERLYTHRNTIDRRLARVDELLPKPFARNPIEVAAALT
Mflv_4621|M.gilvum_PYR-GCK VFLRAGSSFKAAANELQIHANTVKYRVNRALERRGRPIAAERLDVEVALL
TH_3143|M.thermoresistible__bu VFLHVGSSYTAAAERLLLHPNSVRYRVNRAVERRARPIGEDRLEVELALL
MSMEG_1456|M.smegmatis_MC2_155 AYLSEGGNINATARTLNVHRNTMLAKLDRISRMLGMDVRDPEHQFTVWLA
MMAR_2258|M.marinum_M VLQWRSKQPGNPAASGAGKPDDRTPPEQRP
MUL_1854|M.ulcerans_Agy99 ------------------------------
Mb1488|M.bovis_AF2122/97 AQQWREKQTSDPPAKKESNGTKMR------
Rv1453|M.tuberculosis_H37Rv AQQWREKPTSDPPAKKESNGTKMR------
MLBr_01052|M.leprae_Br4923 ALQWRGDQTNTSGPRAGRNDGVPA------
MAB_2657c|M.abscessus_ATCC_199 LLRVRAGR----------------------
Mflv_4621|M.gilvum_PYR-GCK MCYWLGEVALNPTQALGRS-----------
TH_3143|M.thermoresistible__bu ACRHFQQAVLQPAD----------------
MSMEG_1456|M.smegmatis_MC2_155 IRLDLLDEVHSAVEREASFR----------