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M. tuberculosis H37Rv Rv2048c (pks12)

annotation: Probable polyketide synthase pks12
coordinates: 2294531 - 2306986
length: 4151

VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSEFP
TDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGI
DPTGLRGSATGVFAGLIVGGYGMLAEEIEGYRLTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALH
MAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDA
RRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQ
ALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAV
ELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAAR
LAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFV
FPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVS
LAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDL
LAPFGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGI
EPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETF
AACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEG
SGADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGDE
VGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGAD
LSVWPPAGAVTVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDA
VLHAVVIAGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE
RQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHE
SGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLR
GGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD
IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAA
AISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDH
ISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRY
RAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAGT
VLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKV
IADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG
SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALEL
FDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQ
HAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLA
SYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLA
GLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS
ATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLR
SGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPV
LAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG
QDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPR
VWPAGARTRRAGVSSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRG
DDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQ
WLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSW
GVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIA
AVNGPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS
NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMSAL
RKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEAQFVELPTYAFQRRRFWLSGDGVAADAAGLGLAASEHA
LLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLV
LPASGSVAVQVVVNGPDESGVRGVSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVAD
GYQQLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERG
QGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSS
GPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVLQSWLTRDGA
GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRR
GEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDV
MIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAA
TTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDH
ISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRY
RAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGSWAAGT
VLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKV
IADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG
SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADALQL
FDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPED
EQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAA
LAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALANETETSGQDPALAPTAEQ
EIADMDLDDLVNAAFRNDDE*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv2048cpks12-100% (4151)Probable polyketide synthase pks12
M. tuberculosis H37RvRv1661pks70.061.04% (2056) polyketide synthase pks7
M. tuberculosis H37RvRv1662pks80.059.43% (1607) polyketide synthase pks8

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2074cpks120.099.42% (4151) polyketide synthase pks12
M. gilvum PYR-GCKMflv_0405-0.037.06% (2542) beta-ketoacyl synthase
M. leprae Br4923MLBr_00135-0.058.21% (2082) putative polyketide synthase
M. abscessus ATCC 19977MAB_0939-0.035.81% (2547) polyketide synthase
M. marinum MMMAR_3025pks120.083.19% (4188) polyketide synthase, Pks12
M. avium 104MAV_2450-0.080.90% (4177) erythronolide synthase, modules 3 and 4
M. smegmatis MC2 155MSMEG_0408-0.036.18% (2521) type I modular polyketide synthase
M. thermoresistible (build 8)TH_4621-0.034.95% (1874) PUTATIVE mycocerosic acid synthase
M. ulcerans Agy99MUL_2266pks120.082.78% (4192) polyketide synthase, Pks12
M. vanbaalenii PYR-1Mvan_1003-0.037.21% (2548) beta-ketoacyl synthase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0405|M.gilvum_PYR-GCK          -----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG-
MAB_0939|M.abscessus_ATCC_1997      -----------------------MDSAENPIE-STPRFAIIGYAARFPG-
MSMEG_0408|M.smegmatis_MC2_155      -----------------------MVSAEHPIE-PTPSFAIIGYAARFPG-
Mvan_1003|M.vanbaalenii_PYR-1       ---------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG-
Rv2048c|M.tuberculosis_H37Rv        -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG
Mb2074c|M.bovis_AF2122/97           -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG
MMAR_3025|M.marinum_M               -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG
MUL_2266|M.ulcerans_Agy99           -MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGG
MAV_2450|M.avium_104                MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF
MAB_0939|M.abscessus_ATCC_1997      AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF
MSMEG_0408|M.smegmatis_MC2_155      AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF
Mvan_1003|M.vanbaalenii_PYR-1       AADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGF
Rv2048c|M.tuberculosis_H37Rv        VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF
Mb2074c|M.bovis_AF2122/97           VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF
MMAR_3025|M.marinum_M               VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF
MUL_2266|M.ulcerans_Agy99           VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF
MAV_2450|M.avium_104                VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT
MAB_0939|M.abscessus_ATCC_1997      VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET
MSMEG_0408|M.smegmatis_MC2_155      VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS
Mvan_1003|M.vanbaalenii_PYR-1       VEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGT
Rv2048c|M.tuberculosis_H37Rv        VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS
Mb2074c|M.bovis_AF2122/97           VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS
MMAR_3025|M.marinum_M               VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS
MUL_2266|M.ulcerans_Agy99           VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS
MAV_2450|M.avium_104                VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ
MAB_0939|M.abscessus_ATCC_1997      NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ
MSMEG_0408|M.smegmatis_MC2_155      NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ
Mvan_1003|M.vanbaalenii_PYR-1       RTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQ
Rv2048c|M.tuberculosis_H37Rv        ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE
Mb2074c|M.bovis_AF2122/97           ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE
MMAR_3025|M.marinum_M               ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE
MUL_2266|M.ulcerans_Agy99           ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE
MAV_2450|M.avium_104                ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS
MAB_0939|M.abscessus_ATCC_1997      GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS
MSMEG_0408|M.smegmatis_MC2_155      GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS
Mvan_1003|M.vanbaalenii_PYR-1       GPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFS
Rv2048c|M.tuberculosis_H37Rv        GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS
Mb2074c|M.bovis_AF2122/97           GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS
MMAR_3025|M.marinum_M               GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS
MUL_2266|M.ulcerans_Agy99           GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS
MAV_2450|M.avium_104                GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR
MAB_0939|M.abscessus_ATCC_1997      HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR
MSMEG_0408|M.smegmatis_MC2_155      NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR
Mvan_1003|M.vanbaalenii_PYR-1       RARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIR
Rv2048c|M.tuberculosis_H37Rv        RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV
Mb2074c|M.bovis_AF2122/97           RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV
MMAR_3025|M.marinum_M               RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR
MUL_2266|M.ulcerans_Agy99           RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR
MAV_2450|M.avium_104                RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS
MAB_0939|M.abscessus_ATCC_1997      GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS
MSMEG_0408|M.smegmatis_MC2_155      GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS
Mvan_1003|M.vanbaalenii_PYR-1       GSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTP
Rv2048c|M.tuberculosis_H37Rv        GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
Mb2074c|M.bovis_AF2122/97           GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
MMAR_3025|M.marinum_M               GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
MUL_2266|M.ulcerans_Agy99           GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
MAV_2450|M.avium_104                GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LGDPIEAQAAGAALGPGREPQ----RPLLIGSAKTNIGHLEAAAGIAGVI
MAB_0939|M.abscessus_ATCC_1997      LGDPIEAQAAGAAYGIGRETN----DPLLIGSAKTNIGHLEAAAGIAGVI
MSMEG_0408|M.smegmatis_MC2_155      LGDPIEAQAAGEVLGAGRAPE----EPLLIGSAKTNIGHLEAAAGIAGVI
Mvan_1003|M.vanbaalenii_PYR-1       LGDPIEVQAAGAVLGVGREPD----RPLLIGSVKTNIGHLEAASGIAGLL
Rv2048c|M.tuberculosis_H37Rv        LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI
Mb2074c|M.bovis_AF2122/97           LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI
MMAR_3025|M.marinum_M               LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI
MUL_2266|M.ulcerans_Agy99           LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI
MAV_2450|M.avium_104                LGDPIEAQALLATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVI
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          KVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPR
MAB_0939|M.abscessus_ATCC_1997      KVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPR
MSMEG_0408|M.smegmatis_MC2_155      KVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPR
Mvan_1003|M.vanbaalenii_PYR-1       KVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSR
Rv2048c|M.tuberculosis_H37Rv        KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR
Mb2074c|M.bovis_AF2122/97           KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR
MMAR_3025|M.marinum_M               KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR
MUL_2266|M.ulcerans_Agy99           KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR
MAV_2450|M.avium_104                KMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPR
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          IAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTP
MAB_0939|M.abscessus_ATCC_1997      IAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTP
MSMEG_0408|M.smegmatis_MC2_155      IAGVSSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTP
Mvan_1003|M.vanbaalenii_PYR-1       VAGISSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTP
Rv2048c|M.tuberculosis_H37Rv        RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE
Mb2074c|M.bovis_AF2122/97           RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE
MMAR_3025|M.marinum_M               RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG
MUL_2266|M.ulcerans_Agy99           RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG
MAV_2450|M.avium_104                RAGVSSFGISGTNAHVIIEAVPAVEPAHADAPALPVLP----WVVSAKSA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AALMAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAA
MAB_0939|M.abscessus_ATCC_1997      AALAQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAA
MSMEG_0408|M.smegmatis_MC2_155      EALVRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESA
Mvan_1003|M.vanbaalenii_PYR-1       DALAATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSV
Rv2048c|M.tuberculosis_H37Rv        SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL
Mb2074c|M.bovis_AF2122/97           SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL
MMAR_3025|M.marinum_M               SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGVDRDGL
MUL_2266|M.ulcerans_Agy99           SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRDGL
MAV_2450|M.avium_104                AALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGGDRDRL
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTE
MAB_0939|M.abscessus_ATCC_1997      VELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETE
MSMEG_0408|M.smegmatis_MC2_155      IELLGALADDRPA-PGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTE
Mvan_1003|M.vanbaalenii_PYR-1       EELLGALAEDRPG-PGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTE
Rv2048c|M.tuberculosis_H37Rv        LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA
Mb2074c|M.bovis_AF2122/97           LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA
MMAR_3025|M.marinum_M               LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA
MUL_2266|M.ulcerans_Agy99           LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA
MAV_2450|M.avium_104                LAGLDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          PLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPA
MAB_0939|M.abscessus_ATCC_1997      PVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPA
MSMEG_0408|M.smegmatis_MC2_155      PVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPA
Mvan_1003|M.vanbaalenii_PYR-1       PVYREVMTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPA
Rv2048c|M.tuberculosis_H37Rv        PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV
Mb2074c|M.bovis_AF2122/97           PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV
MMAR_3025|M.marinum_M               PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRVDVVQPV
MUL_2266|M.ulcerans_Agy99           PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRIDVVQPV
MAV_2450|M.avium_104                PVFAQHIQACEEAFAEFVDWSLIDALRGAP------GAAGMDRVDVVQPA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAE
MAB_0939|M.abscessus_ATCC_1997      LFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAE
MSMEG_0408|M.smegmatis_MC2_155      LFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAE
Mvan_1003|M.vanbaalenii_PYR-1       LYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAE
Rv2048c|M.tuberculosis_H37Rv        LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL
Mb2074c|M.bovis_AF2122/97           LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL
MMAR_3025|M.marinum_M               LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL
MUL_2266|M.ulcerans_Agy99           LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL
MAV_2450|M.avium_104                LFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          RGRLFGSLPSGGRMAAVFAAAERVEALTDEY-PALSVAAYNG-ANTVLSG
MAB_0939|M.abscessus_ATCC_1997      RGRLFSSLPAGGRMAAVFTDAERAERLTDEF-PSLSVAAYNG-ANTVLSG
MSMEG_0408|M.smegmatis_MC2_155      RGRLFGSLPAGGRMAAVFTAPERAERLTDEY-PSLSVAAYNG-ANTVLSG
Mvan_1003|M.vanbaalenii_PYR-1       RGRLFGSLPEGGRMAAVFAPADRVESCTVDS-PLLSVAAYNG-DNTVLSG
Rv2048c|M.tuberculosis_H37Rv        RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG
Mb2074c|M.bovis_AF2122/97           RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG
MMAR_3025|M.marinum_M               RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG
MUL_2266|M.ulcerans_Agy99           RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG
MAV_2450|M.avium_104                RSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSG
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          PATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFT
MAB_0939|M.abscessus_ATCC_1997      PAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYK
MSMEG_0408|M.smegmatis_MC2_155      PAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYR
Mvan_1003|M.vanbaalenii_PYR-1       PAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFG
Rv2048c|M.tuberculosis_H37Rv        EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR
Mb2074c|M.bovis_AF2122/97           EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR
MMAR_3025|M.marinum_M               EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL
MUL_2266|M.ulcerans_Agy99           EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL
MAV_2450|M.avium_104                EGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPR
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          APQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKL
MAB_0939|M.abscessus_ATCC_1997      TPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKV
MSMEG_0408|M.smegmatis_MC2_155      EPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRV
Mvan_1003|M.vanbaalenii_PYR-1       TPQRTLVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVRTLADLGCRL
Rv2048c|M.tuberculosis_H37Rv        STRTVFFSTVTGNRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQGYRT
Mb2074c|M.bovis_AF2122/97           STRTVFFSTVTGNRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQGYRT
MMAR_3025|M.marinum_M               SSRTAFFSSVTGSRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGHGYRT
MUL_2266|M.ulcerans_Agy99           SSRTAFFSSVTGSRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGHGYRT
MAV_2450|M.avium_104                SSRIAFFSTVTGNRLD-TAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRT
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LVEIGPRPVLTAAALSAWP----DPATSPRVIASLRRTTADQRQITEAVA
MAB_0939|M.abscessus_ATCC_1997      LLEIGPQPVLTAAALRAWP----DPATAPRAIASLRRNTADHRQITEAAA
MSMEG_0408|M.smegmatis_MC2_155      LLEIGPRPVLTATALAAWP----DPATTPQVLASLRPTTADHRQITEAVA
Mvan_1003|M.vanbaalenii_PYR-1       LMEIGPQPVLTAAAMRTWP----GTVTAPRVAASMRRKGSDRRQITEALA
Rv2048c|M.tuberculosis_H37Rv        FIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFLLSAA
Mb2074c|M.bovis_AF2122/97           FIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFLLSAA
MMAR_3025|M.marinum_M               FIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA
MUL_2266|M.ulcerans_Agy99           FIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA
MAV_2450|M.avium_104                FIESSPHPALVAGIEDTVNDSLPGD-TEAIVIPTLGRDDGGLERFLTSAA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          DAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDSRE---PVAAAP
MAB_0939|M.abscessus_ATCC_1997      DAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGDNRDAGNR
MSMEG_0408|M.smegmatis_MC2_155      AAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTAS
Mvan_1003|M.vanbaalenii_PYR-1       QAYVAGHRPETAARQHGRGRLLDLPTYPFQHRAYWFP--------QGQAR
Rv2048c|M.tuberculosis_H37Rv        SAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGL
Mb2074c|M.bovis_AF2122/97           SAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGL
MMAR_3025|M.marinum_M               AAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDASGLGL
MUL_2266|M.ulcerans_Agy99           AAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDASGLGL
MAV_2450|M.avium_104                TAFVAGVNVAWRGVLDG-AGFVELPTYAFDRRRFWLSGEGAAADASGLGL
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          QR---GARTETVRLLEDGRIEELAALLGGTV-------------------
MAB_0939|M.abscessus_ATCC_1997      QQNNGGPRTEAVRLLEDGKIEELANLLGGVD-------------------
MSMEG_0408|M.smegmatis_MC2_155      AGSVTPHRTQAVRLLEDGQIEELAALIDGET-------------------
Mvan_1003|M.vanbaalenii_PYR-1       TAPTDPVHTETVRFLDEERIDELAALLDGPT-------------------
Rv2048c|M.tuberculosis_H37Rv        GASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGF
Mb2074c|M.bovis_AF2122/97           GASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGF
MMAR_3025|M.marinum_M               SAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFPGTGF
MUL_2266|M.ulcerans_Agy99           SAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFPGTGF
MAV_2450|M.avium_104                GTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFPGAGF
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          -------DDPFTFDVLNRLAAQHNQQRSTE--------------------
MAB_0939|M.abscessus_ATCC_1997      -------GDQQTLNVLTKLAAQHNLQRTTQ--------------------
MSMEG_0408|M.smegmatis_MC2_155      -------VDEQTLRVLNKLAARHNQQRSTH--------------------
Mvan_1003|M.vanbaalenii_PYR-1       -------GSAQTVDVLSKLAARHRQQRGAQ--------------------
Rv2048c|M.tuberculosis_H37Rv        VELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSN
Mb2074c|M.bovis_AF2122/97           VELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSN
MMAR_3025|M.marinum_M               VELAIRAGDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAAADSA
MUL_2266|M.ulcerans_Agy99           VELAIRAVDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAAADSA
MAV_2450|M.avium_104                VELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEADESG
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ---------------SIADDRYQIRWETAAEPPVGADAADGITWLLVGDD
MAB_0939|M.abscessus_ATCC_1997      ---------------TIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADA
MSMEG_0408|M.smegmatis_MC2_155      ---------------VDPDARYEIRWDAIASAAASTGAAA--DWILVGDD
Mvan_1003|M.vanbaalenii_PYR-1       ---------------SIADARYQIRWEKSEAPGAARPTTEATTWLLVTHD
Rv2048c|M.tuberculosis_H37Rv        SRGVSIFSR------ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAV
Mb2074c|M.bovis_AF2122/97           SRGVSIFSR------ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAV
MMAR_3025|M.marinum_M               ERSVSIYSR----TDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAI
MUL_2266|M.ulcerans_Agy99           ERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAI
MAV_2450|M.avium_104                RRDVSIFSR------PDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGAT
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          TDATRPLVDVLAARGHRY--------------------------------
MAB_0939|M.abscessus_ATCC_1997      AGAAQPLLDVLTARGQQH--------------------------------
MSMEG_0408|M.smegmatis_MC2_155      TAAVLEFADALTAGGHRH--------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       SRAAQPIAEVLERRGHPY--------------------------------
Rv2048c|M.tuberculosis_H37Rv        TVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGG
Mb2074c|M.bovis_AF2122/97           TVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGG
MMAR_3025|M.marinum_M               AVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEVRLPEAAGSTSG
MUL_2266|M.ulcerans_Agy99           AVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAGSTSG
MAV_2450|M.avium_104                KVDIADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTG
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        FGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASAVRAR
Mb2074c|M.bovis_AF2122/97           FGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASAVRAR
MMAR_3025|M.marinum_M               FGVHPALLDAALHTAVI----ANPDAELVLPFSWQGVSLHAAGAASVRVR
MUL_2266|M.ulcerans_Agy99           FGVHPALLDAALHTAVI----ANPDADLVLPFSWQGVSLHAAGAASVRVR
MAV_2450|M.avium_104                FGVHPALLDAAMHALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRAR
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ----------------------------RILGLPKSGAEEHELADTLRDA
MAB_0939|M.abscessus_ATCC_1997      ----------------------------RVLALPVSDADEAELVEALRSA
MSMEG_0408|M.smegmatis_MC2_155      ----------------------------QIVALPGSDADEAQLVDTLRAA
Mvan_1003|M.vanbaalenii_PYR-1       ----------------------------HIVGLPGSDADAAPAEEALRAT
Rv2048c|M.tuberculosis_H37Rv        IAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGS
Mb2074c|M.bovis_AF2122/97           IAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGS
MMAR_3025|M.marinum_M               IAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAVVSAS
MUL_2266|M.ulcerans_Agy99           IAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAVVSAS
MAV_2450|M.avium_104                LAPAQAPGTAASRAVSLELADGLGLPVLSVRAMVARSVSERQLRAAVSAA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQL
MAB_0939|M.abscessus_ATCC_1997      ADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAEL
MSMEG_0408|M.smegmatis_MC2_155      SAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFRAANDAEL
Mvan_1003|M.vanbaalenii_PYR-1       VSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQLAATAGA
Rv2048c|M.tuberculosis_H37Rv        GPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALA
Mb2074c|M.bovis_AF2122/97           GPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALA
MMAR_3025|M.marinum_M               GPDRLFEVVWTPMTVAAT-DAAPAYELFESVAAEGDPLSGTYQRTHQALA
MUL_2266|M.ulcerans_Agy99           GPDRLFEVVWTPMTVAAT-DAAPAYELFESIAADGDPLSGTYQRTHQALA
MAV_2450|M.avium_104                GPDRLFEVAWAPVTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHEALA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          RSPMWL----------VTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQ
MAB_0939|M.abscessus_ATCC_1997      RAPIWI----------VTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQ
MSMEG_0408|M.smegmatis_MC2_155      RSPIWL----------VTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPH
Mvan_1003|M.vanbaalenii_PYR-1       RAPIWL----------ITAGAQRITGDETVEPAQTSLWGFGRAAALEQPE
Rv2048c|M.tuberculosis_H37Rv        AVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPG
Mb2074c|M.bovis_AF2122/97           AVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPG
MMAR_3025|M.marinum_M               AVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPG
MUL_2266|M.ulcerans_Agy99           AVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPG
MAV_2450|M.avium_104                AVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQTEHPG
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ----------------------------IWGG------------------
MAB_0939|M.abscessus_ATCC_1997      ----------------------------VWGG------------------
MSMEG_0408|M.smegmatis_MC2_155      ----------------------------IWGG------------------
Mvan_1003|M.vanbaalenii_PYR-1       ----------------------------LWGG------------------
Rv2048c|M.tuberculosis_H37Rv        RIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILV
Mb2074c|M.bovis_AF2122/97           RIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILV
MMAR_3025|M.marinum_M               RLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILV
MUL_2266|M.ulcerans_Agy99           RLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILV
MAV_2450|M.avium_104                RIVLIDSDAALDDSALTAALATGEPQVLLRDGTVYTARVHGSRAVDGIMT
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          -------LADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPR
MAB_0939|M.abscessus_ATCC_1997      -------LADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPR
MSMEG_0408|M.smegmatis_MC2_155      -------LADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPR
Mvan_1003|M.vanbaalenii_PYR-1       -------LADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVAR
Rv2048c|M.tuberculosis_H37Rv        PPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD
Mb2074c|M.bovis_AF2122/97           PPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD
MMAR_3025|M.marinum_M               PPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRD
MUL_2266|M.ulcerans_Agy99           PPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRD
MAV_2450|M.avium_104                PPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRD
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          LVHRDTLPSGKPLHLRADA-------------------------------
MAB_0939|M.abscessus_ATCC_1997      LVRREELPSGKPLEVRSDA-------------------------------
MSMEG_0408|M.smegmatis_MC2_155      LVRRTGEPSDTPLPVREDR-------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       LTRCAEKANAAALELRREA-------------------------------
Rv2048c|M.tuberculosis_H37Rv        IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLV
Mb2074c|M.bovis_AF2122/97           IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLV
MMAR_3025|M.marinum_M               IMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLV
MUL_2266|M.ulcerans_Agy99           IMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLV
MAV_2450|M.avium_104                VMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSGTLV
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        AGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAG
Mb2074c|M.bovis_AF2122/97           AGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAG
MMAR_3025|M.marinum_M               AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA
MUL_2266|M.ulcerans_Agy99           AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA
MAV_2450|M.avium_104                PGDVRLLQHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        TGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFE
Mb2074c|M.bovis_AF2122/97           TGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFE
MMAR_3025|M.marinum_M               TGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFE
MUL_2266|M.ulcerans_Agy99           TGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFE
MAV_2450|M.avium_104                AGGVGMAAVQLARHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLEFE
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        DKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV
Mb2074c|M.bovis_AF2122/97           DKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV
MMAR_3025|M.marinum_M               EKFREVTGGRGVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGV
MUL_2266|M.ulcerans_Agy99           EKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGV
MAV_2450|M.avium_104                DKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          --------------------------------------------------
MAB_0939|M.abscessus_ATCC_1997      --------------------------------------------------
MSMEG_0408|M.smegmatis_MC2_155      --------------------------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       --------------------------------------------------
Rv2048c|M.tuberculosis_H37Rv        IAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVR
Mb2074c|M.bovis_AF2122/97           IAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVR
MMAR_3025|M.marinum_M               IAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVR
MUL_2266|M.ulcerans_Agy99           IAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVR
MAV_2450|M.avium_104                VAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTTFDIR
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          ---------------------------------TYLVTGGLGSLGLEIAG
MAB_0939|M.abscessus_ATCC_1997      ---------------------------------TYLVTGGLGSIGLEIAG
MSMEG_0408|M.smegmatis_MC2_155      ---------------------------------TYLVTGGLGAIGLEVAG
Mvan_1003|M.vanbaalenii_PYR-1       ---------------------------------TYLVTGGLGALGLEVAE
Rv2048c|M.tuberculosis_H37Rv        RAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGSAVAR
Mb2074c|M.bovis_AF2122/97           RAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGSAVAR
MMAR_3025|M.marinum_M               RAPAALRYLSQARHIGKVVMTMPADQGGALGGGTVLITGGTGMAGSALAR
MUL_2266|M.ulcerans_Agy99           RAPAALRYLSQARHVGKVVMTMPADQGGALGGGTVLITGGTGMAGSALAR
MAV_2450|M.avium_104                RGRAALRYLSQARHIGKVVMTVPG----ALSAGTVLITGGTGMAGSTLAR
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          YLAA-NGAGHLVLTSRRTPDEAAASRIEALRERHGCEVRVVTADVADAHA
MAB_0939|M.abscessus_ATCC_1997      YLAG-RGAKHLVLTSRREPGEAARQRIDALAA-QGCEVRAVTADVADGHD
MSMEG_0408|M.smegmatis_MC2_155      YLAS-HGAGHVVLTSRREPGDDARRRLDGLREQYACDVRVITADVADAHD
Mvan_1003|M.vanbaalenii_PYR-1       FLAS-HGAGHLVLTGRRSASDTVRQRIDAMRERFDCQVLVATADVADRDD
Rv2048c|M.tuberculosis_H37Rv        HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAA
Mb2074c|M.bovis_AF2122/97           HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAA
MMAR_3025|M.marinum_M               HLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPA
MUL_2266|M.ulcerans_Agy99           HLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPA
MAV_2450|M.avium_104                HLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVIACDAADRAA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          VARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVDRVFAGKVWGAW
MAB_0939|M.abscessus_ATCC_1997      VARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAGKVWGAW
MSMEG_0408|M.smegmatis_MC2_155      VARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAW
Mvan_1003|M.vanbaalenii_PYR-1       VARLFSTMRSELPPLAGIVHAAGEIGTSPLRTLDDAEMDRVFAGKVWGAV
Rv2048c|M.tuberculosis_H37Rv        LAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAW
Mb2074c|M.bovis_AF2122/97           LAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAW
MMAR_3025|M.marinum_M               LAKVIAEIPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAW
MUL_2266|M.ulcerans_Agy99           LAKVIAENPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAW
MAV_2450|M.avium_104                LAGVIAGISAERP-LSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAW
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          HLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAANAFLDGLAWRLRE
MAB_0939|M.abscessus_ATCC_1997      HLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAANAFLDGLAWRLRE
MSMEG_0408|M.smegmatis_MC2_155      HLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFLDGLAWRLRE
Mvan_1003|M.vanbaalenii_PYR-1       YLCEEVADMG--LDFFLATSSIASVWGSHGQTAYGAANAFLDGLADSLRA
Rv2048c|M.tuberculosis_H37Rv        HLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRA
Mb2074c|M.bovis_AF2122/97           HLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRA
MMAR_3025|M.marinum_M               NLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRA
MUL_2266|M.ulcerans_Agy99           NLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRA
MAV_2450|M.avium_104                NLHELTRDMN--LSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRRA
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          QGVAGVSVNFGPWS-----AGMADAQSRARLEQRGIKTLSPADALAGLSD
MAB_0939|M.abscessus_ATCC_1997      QGIAGTSVNFGPWS-----AGMADAESRARLEQRGIKTLSPTDALAGLAD
MSMEG_0408|M.smegmatis_MC2_155      RGVTAVSVNFGPWA-----AGMADAESRARLEQRGVRTLSPAEALAGMAD
Mvan_1003|M.vanbaalenii_PYR-1       RGIPGISVNFGPWA-----AGMADAKAREQLSRRGVKTLAPADALAGMAD
Rv2048c|M.tuberculosis_H37Rv        HGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDT
Mb2074c|M.bovis_AF2122/97           HGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALSTAEALELFDT
MMAR_3025|M.marinum_M               HGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDT
MUL_2266|M.ulcerans_Agy99           HGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDT
MAV_2450|M.avium_104                HGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGILALSSDEAMELFDT
MLBr_00135|M.leprae_Br4923          ------------------MTASVEGADQK---------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQG
MAB_0939|M.abscessus_ATCC_1997      VVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLA--G
MSMEG_0408|M.smegmatis_MC2_155      VVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAA
Mvan_1003|M.vanbaalenii_PYR-1       VIAASTA---HAVVARIDWATFLPVYQLQRRRAFLSQLEREVPDVPD--A
Rv2048c|M.tuberculosis_H37Rv        AMIVDEP-----FLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDS
Mb2074c|M.bovis_AF2122/97           AMIVDEP-----FLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDS
MMAR_3025|M.marinum_M               ALIVNQA-----FLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQVDDA
MUL_2266|M.ulcerans_Agy99           ALIVNQA-----FLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQIDAA
MAV_2450|M.avium_104                ALIVDEP-----FLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDS
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          PAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDA
MAB_0939|M.abscessus_ATCC_1997      VAGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDA
MSMEG_0408|M.smegmatis_MC2_155      APATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEA
Mvan_1003|M.vanbaalenii_PYR-1       SAPAPSGTTRFVEELTLAPVEQRRKLVLEYLRAAVAEVTRVDAAEIRDEA
Rv2048c|M.tuberculosis_H37Rv        VAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDK
Mb2074c|M.bovis_AF2122/97           VAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDK
MMAR_3025|M.marinum_M               LAAAKSKSALAHRLHGLPEPEQHAVVLDLVRSHIATVLGTITPEAIDPDK
MUL_2266|M.ulcerans_Agy99           LATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAIDPDK
MAV_2450|M.avium_104                LAAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDK
MLBr_00135|M.leprae_Br4923          --------------------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          GFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYLLGDVL
MAB_0939|M.abscessus_ATCC_1997      GFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVL
MSMEG_0408|M.smegmatis_MC2_155      GFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLLVEVL
Mvan_1003|M.vanbaalenii_PYR-1       GFFDLGMDSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVLGDVL
Rv2048c|M.tuberculosis_H37Rv        AFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELA
Mb2074c|M.bovis_AF2122/97           AFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELA
MMAR_3025|M.marinum_M               AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELA
MUL_2266|M.ulcerans_Agy99           AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELA
MAV_2450|M.avium_104                AFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELA
MLBr_00135|M.leprae_Br4923          -------------------------------------SEKLISYLKKVVV
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          GLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPG-APNPEAFWDLLSGG
MAB_0939|M.abscessus_ATCC_1997      GLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPG-APDPEAFWDVLSGG
MSMEG_0408|M.smegmatis_MC2_155      GLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPG-APDPESFWELLAGG
Mvan_1003|M.vanbaalenii_PYR-1       GLSEHTV--AQPDTPSTVRTDDPIAIVGMACRFPG-ADDTDAFWSVLAEG
Rv2048c|M.tuberculosis_H37Rv        GLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG
Mb2074c|M.bovis_AF2122/97           GLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG
MMAR_3025|M.marinum_M               GAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR
MUL_2266|M.ulcerans_Agy99           GAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR
MAV_2450|M.avium_104                GAPQETT----HAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQMVAEG
MLBr_00135|M.leprae_Br4923          ELDETRA----RLREYEQRATEPVAVVGIGCRFPGGVDSPDRLWDVVSEC
TH_4621|M.thermoresistible__bu      ------------VNIVGDTPVNAVAVIGMACRLPGGIDSPQRLWEALLRG
                                                         :.:*::.:.** **   ..: :*. :   

Mflv_0405|M.gilvum_PYR-GCK          VDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFFGL
MAB_0939|M.abscessus_ATCC_1997      VDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFFGI
MSMEG_0408|M.smegmatis_MC2_155      VDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFFGI
Mvan_1003|M.vanbaalenii_PYR-1       ADLIREIPDDR-FDINEFYDPDPEAAGKIYSRYGGFLDGVDGFDPEFFGI
Rv2048c|M.tuberculosis_H37Rv        RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV
Mb2074c|M.bovis_AF2122/97           RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV
MMAR_3025|M.marinum_M               RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFDPAFFGV
MUL_2266|M.ulcerans_Agy99           RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFEPAFFGV
MAV_2450|M.avium_104                RDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGI
MLBr_00135|M.leprae_Br4923          RDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGI
TH_4621|M.thermoresistible__bu      DDMVTEIPVDR-WDADDYFDPEPGVPGRTVSRWGAFLDDVAGFDPEFFGI
                                     * : :.* ** :*    ::*:* . *   :* *.*:*    *:. ***:

Mflv_0405|M.gilvum_PYR-GCK          SPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGVAANEYA
MAB_0939|M.abscessus_ATCC_1997      SPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGVGANEYA
MSMEG_0408|M.smegmatis_MC2_155      SPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGVAANEYA
Mvan_1003|M.vanbaalenii_PYR-1       SPREAVWIDPQQRLVLETAWEGLERAGYSAAALRGSRSGVYVGVGANEYS
Rv2048c|M.tuberculosis_H37Rv        GPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG
Mb2074c|M.bovis_AF2122/97           GPSEALAMDPQQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG
MMAR_3025|M.marinum_M               GPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYG
MUL_2266|M.ulcerans_Agy99           GPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYG
MAV_2450|M.avium_104                APSEALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGYG
MLBr_00135|M.leprae_Br4923          APSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTGIFAPSYG
TH_4621|M.thermoresistible__bu      SEREAISIDPQQRLLLETSWEAMEHAGLTPADVEGSSTGVFVGLSHDDYA
                                    .  *.: ::**:*:.**  **.:* **  .  :.** :*::.*:    *.

Mflv_0405|M.gilvum_PYR-GCK          HLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTACSSSLV
MAB_0939|M.abscessus_ATCC_1997      HLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTACSSALV
MSMEG_0408|M.smegmatis_MC2_155      HLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTACSSALV
Mvan_1003|M.vanbaalenii_PYR-1       HLLSGGSLDGIEAQFITGNALNVIAGRVSFTLGLEGPAVAVDTACSSSLV
Rv2048c|M.tuberculosis_H37Rv        MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV
Mb2074c|M.bovis_AF2122/97           MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV
MMAR_3025|M.marinum_M               MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV
MUL_2266|M.ulcerans_Agy99           MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV
MAV_2450|M.avium_104                MGAAPI----AEGFRLTGQSSSVASGRVSYVLGLEGPAVSVDTACSSSLV
MLBr_00135|M.leprae_Br4923          SRDTGG----LQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLV
TH_4621|M.thermoresistible__bu      LLTSDAG-ALEEAYGFTGSAFSMASGRIAYRLGVHGPAVTVDTACSSSLL
                                       :       :   :**   .  :**::: **..****:*******:*:

Mflv_0405|M.gilvum_PYR-GCK          AVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFD
MAB_0939|M.abscessus_ATCC_1997      AVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGRCKTFD
MSMEG_0408|M.smegmatis_MC2_155      AVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFD
Mvan_1003|M.vanbaalenii_PYR-1       AVHQACQGLQSGDCDLALAGGVNVLLSPATTIATSRARMLSPDGRCKTFD
Rv2048c|M.tuberculosis_H37Rv        ALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFA
Mb2074c|M.bovis_AF2122/97           ALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFA
MMAR_3025|M.marinum_M               ALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFA
MUL_2266|M.ulcerans_Agy99           ALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFA
MAV_2450|M.avium_104                ALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRCKAYA
MLBr_00135|M.leprae_Br4923          AIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFA
TH_4621|M.thermoresistible__bu      AVHMACRSLQVGESDLALAGGAMVMLEPRKYTSASGLGMLSPTGRCHAFD
                                    *:* *  .*: *:.*:*****. :   *      *    *:  ***::: 

Mflv_0405|M.gilvum_PYR-GCK          ASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGASSGLTV
MAB_0939|M.abscessus_ATCC_1997      ASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGASSGLTV
MSMEG_0408|M.smegmatis_MC2_155      ASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGASSGLTV
Mvan_1003|M.vanbaalenii_PYR-1       AAADGYVRGEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDGASGGLTV
Rv2048c|M.tuberculosis_H37Rv        AAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTA
Mb2074c|M.bovis_AF2122/97           AAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTA
MMAR_3025|M.marinum_M               GAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTA
MUL_2266|M.ulcerans_Agy99           GAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTA
MAV_2450|M.avium_104                GAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQDGASNGLTA
MLBr_00135|M.leprae_Br4923          RAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLTA
TH_4621|M.thermoresistible__bu      VAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVRGTAANQDGRTENIST
                                     :***   .**  :::::**.** * .. : *:: .::.**** : .::.

Mflv_0405|M.gilvum_PYR-GCK          PNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQAAAAAYA
MAB_0939|M.abscessus_ATCC_1997      PNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAAAAYG
MSMEG_0408|M.smegmatis_MC2_155      PNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQAAAAAYG
Mvan_1003|M.vanbaalenii_PYR-1       PNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQAAGAVLG
Rv2048c|M.tuberculosis_H37Rv        PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG
Mb2074c|M.bovis_AF2122/97           PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG
MMAR_3025|M.marinum_M               PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG
MUL_2266|M.ulcerans_Agy99           PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG
MAV_2450|M.avium_104                PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG
MLBr_00135|M.leprae_Br4923          PNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQALLATYG
TH_4621|M.thermoresistible__bu      PSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTPVGDPIEYNSLTQVYG
                                    *.  :*  :  :.*: **:  . :. :*.***.*.:***** ::   . .

Mflv_0405|M.gilvum_PYR-GCK          GARDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQSL
MAB_0939|M.abscessus_ATCC_1997      GSRDAD----RPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQSL
MSMEG_0408|M.smegmatis_MC2_155      AGRDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLPQSL
Mvan_1003|M.vanbaalenii_PYR-1       AGRDPD----RPLLMGSVKTNVGHLESASGVAGLIKVVLSLQHEMLPRHL
Rv2048c|M.tuberculosis_H37Rv        QDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL
Mb2074c|M.bovis_AF2122/97           QDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL
MMAR_3025|M.marinum_M               QDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATL
MUL_2266|M.ulcerans_Agy99           QDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATL
MAV_2450|M.avium_104                QDRGQP------LWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL
MLBr_00135|M.leprae_Br4923          QGRPAD----QPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVMPATL
TH_4621|M.thermoresistible__bu      KTGPCA--------LTSVKTNFGHAESAAGALGMMKAILALQHGVVPQNL
                                                  : *:*:*.** ::*:*. *::* : ::::  :*  *

Mflv_0405|M.gilvum_PYR-GCK          HFDTPSPHIPWDSLPVRVVDTAMPWQ---PNGRPRRAGVSSFGFTGTNAH
MAB_0939|M.abscessus_ATCC_1997      HFDNPSPHIPWESLPVRVVDKAIPWQ---ANGRPRRAGVSSFGFTGTNAH
MSMEG_0408|M.smegmatis_MC2_155      HFENPSPHIPWDALPVRVIDEPVPWQ---TNGRVRRAGVSSFGFTGTNAH
Mvan_1003|M.vanbaalenii_PYR-1       HFKTPSPHIPWDRLAVRVVAEPTPWR---ADGRPRRAGVSSFGFSGTNAH
Rv2048c|M.tuberculosis_H37Rv        HVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISGTNAH
Mb2074c|M.bovis_AF2122/97           HVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISGTNAH
MMAR_3025|M.marinum_M               HVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAH
MUL_2266|M.ulcerans_Agy99           HVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAH
MAV_2450|M.avium_104                HVDEPSPHVDWSAGAVSLLTEAQPWP----GERPRRAGVSSFGISGTNAH
MLBr_00135|M.leprae_Br4923          HVDEPSPRVDWTTGAVSVLTEARDWS---VEGRPRRAGVSSFGISGTNAH
TH_4621|M.thermoresistible__bu      HFTRLPDEMAAIETNLFVPQATTLWP--VREGCPRRAAVSSYGMSGTNVH
                                    *.   . .:      : :   .  *         ***.***:*::***.*

Mflv_0405|M.gilvum_PYR-GCK          VLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALV
MAB_0939|M.abscessus_ATCC_1997      VLIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSPEALA
MSMEG_0408|M.smegmatis_MC2_155      VLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSPEALV
Mvan_1003|M.vanbaalenii_PYR-1       VVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAGVLPISARSPEALT
Rv2048c|M.tuberculosis_H37Rv        VIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSESALR
Mb2074c|M.bovis_AF2122/97           VIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSESALR
MMAR_3025|M.marinum_M               VIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSGSALG
MUL_2266|M.ulcerans_Agy99           VIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSGSALG
MAV_2450|M.avium_104                VIIEAVP---------------AVEPAHADAPALPVLPWVVSAKSAAALR
MLBr_00135|M.leprae_Br4923          VILEEAPTP------------VEASYSTADQQRLSVVPWVVSGRSTAALM
TH_4621|M.thermoresistible__bu      AVLEQAPEP------------VQRPEESADTDAAGPLVFALSSTSAEELR
                                    .::*  *                                 :*. *   * 

Mflv_0405|M.gilvum_PYR-GCK          ALAQRYETWLTAH-PEADLADVCRTAGTGRSHFEHRAALVVDSVESARIA
MAB_0939|M.abscessus_ATCC_1997      AVAQRYESWLAAH-PDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREG
MSMEG_0408|M.smegmatis_MC2_155      ELARRYDDWLSAT-PGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREG
Mvan_1003|M.vanbaalenii_PYR-1       ALARRYESWLTAH-PDADIADVCYTAGAGRSHFEHRAALVVDSVDGARDL
Rv2048c|M.tuberculosis_H37Rv        GQAARLAAYVRGD-DGLDVADVGWSLA-GRSVFEHRAVVVGGDRDRLLAG
Mb2074c|M.bovis_AF2122/97           GQAARLAAYVRGD-DGLDVADVGWSLA-GRSVFEHRAVVVGGDRDRLLAG
MMAR_3025|M.marinum_M               AQAARLAAHVRSH-DELDVADVGWSLA-GRSTFEHRAVVLGVDRDGLLAG
MUL_2266|M.ulcerans_Agy99           AQAARLAAHVRSH-DELDVADVGWSLA-GRSTFEHRAVVLGADRDGLLAG
MAV_2450|M.avium_104                AQAARLAEYVRAQ-GELDIADVGWTLA-GRATFEHRAVVVGGDRDRLLAG
MLBr_00135|M.leprae_Br4923          AQASRLAFYVQAD-PEVDPVDVGCALA-ARSVFEHRAVVVGESREQLIAG
TH_4621|M.thermoresistible__bu      RTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVIADGVEALTAG
                                      * *    : .        *:  : .  *:    *:.::  . :     

Mflv_0405|M.gilvum_PYR-GCK          LTDLAQNRLR-PGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVF
MAB_0939|M.abscessus_ATCC_1997      LLELAQNRLR-PGVVRGEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVF
MSMEG_0408|M.smegmatis_MC2_155      LAALAEGRTP-AGVVRGEHVHRPTTAWLFTGQGSQYPGMARELFDTQPVF
Mvan_1003|M.vanbaalenii_PYR-1       LAGLAEDRLG-PGAVRGVCGDPPKTAWLFTGQGSQYPGMARELFDTEPVF
Rv2048c|M.tuberculosis_H37Rv        LDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVF
Mb2074c|M.bovis_AF2122/97           LDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVF
MMAR_3025|M.marinum_M               LDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVF
MUL_2266|M.ulcerans_Agy99           LDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVF
MAV_2450|M.avium_104                LDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVF
MLBr_00135|M.leprae_Br4923          LAGLAVGESG-AGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVF
TH_4621|M.thermoresistible__bu      LREVADGDAP---YQPAVGMDDKAPVWVFSGQGSQWAGMGAELLATEQVF
                                    *  :* .         .       .. :*.***:*  **.  *     **

Mflv_0405|M.gilvum_PYR-GCK          ADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFA
MAB_0939|M.abscessus_ATCC_1997      AETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTSFAQPALFA
MSMEG_0408|M.smegmatis_MC2_155      AQTVRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHTSFAQPALFA
Mvan_1003|M.vanbaalenii_PYR-1       RDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----GQTLRHTSYAQPALFA
Rv2048c|M.tuberculosis_H37Rv        AEAFNTVVGELDRHLLRPLREVMWGH-------DENLLNSTEFAQPALFA
Mb2074c|M.bovis_AF2122/97           AEAFNTVVGELDRHLLRPLREVMWGH-------DENLLNSTEFAQPALFA
MMAR_3025|M.marinum_M               AEAFNTVVGELDRHLLRPLREVIWGH-------DENLLNTTEFAQPALFA
MUL_2266|M.ulcerans_Agy99           AEAFNTVVGELDRHLLRPLREVIWGH-------DENLLNTTEFAQPALFA
MAV_2450|M.avium_104                AEAFDAVVAELDRHLLRPLRDVIWGD-------DENVLNSTEFAQPALFA
MLBr_00135|M.leprae_Br4923          AEEFDAVTGELDRHMRLPLRDVVWGA-------DAGLLDSTEFAQPALFA
TH_4621|M.thermoresistible__bu      AAKIAEIEPLVARESGFSVTEAMTAS---------ETVTGIDRVQPTLFA
                                       .      :      .: :.:              :   . .**:***

Mflv_0405|M.gilvum_PYR-GCK          VEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGR
MAB_0939|M.abscessus_ATCC_1997      VEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGR
MSMEG_0408|M.smegmatis_MC2_155      VEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGARLMAERGR
Mvan_1003|M.vanbaalenii_PYR-1       IEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFGLEDGARLVADRGR
Rv2048c|M.tuberculosis_H37Rv        VEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGR
Mb2074c|M.bovis_AF2122/97           VEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGR
MMAR_3025|M.marinum_M               VEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGR
MUL_2266|M.ulcerans_Agy99           VEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGR
MAV_2450|M.avium_104                VEVALFRLLESWGVRPDFVMGHSIGELSAAHVAGVLSLQNAAVLVAARGR
MLBr_00135|M.leprae_Br4923          VEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAAMLVVARGR
TH_4621|M.thermoresistible__bu      IQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDGVKVICRRSR
                                    :::.*       .: *. *:***:*: :** ***.:.  :.. ::  *.*

Mflv_0405|M.gilvum_PYR-GCK          LFGSLPEGGRMVAVFADAKRVEQVAADF--PRVSVGAYNGPN-TVLSGPG
MAB_0939|M.abscessus_ATCC_1997      LFGGLPAGGRMVAVFSDAKHVEQIAGEF--PRVSVGAYNGPN-TVLSGPG
MSMEG_0408|M.smegmatis_MC2_155      MFGSLPEGGRMVAVFADAEHVEQVAGEF--PRVSVGAYNGPN-TVLSGPG
Mvan_1003|M.vanbaalenii_PYR-1       LFGGLPVGGRMVAVFTDAEVVEDFADEF--PQVSVAAYNGPN-TVLAGPA
Rv2048c|M.tuberculosis_H37Rv        LMQALPAGGAMVAVQAAEEEVRPLLS----AEVDIAAVNGPASLVISGAQ
Mb2074c|M.bovis_AF2122/97           LMQALPAGGAMVAVQAAEEEVRPLLS----AEVDIAAVNGPASLVISGAQ
MMAR_3025|M.marinum_M               LMQALPDGGAMIAVQATEQEVLPLLG----AQVSIAAINGPASVVISGAQ
MUL_2266|M.ulcerans_Agy99           LMQALPDGGAMIAVQATEQEVLPLLG----AQVSIATINGPASVVISGAQ
MAV_2450|M.avium_104                FMQALPEGGAMIAVQATEAQVRPLLG----PDVGIAAVNGPAAVVISGDH
MLBr_00135|M.leprae_Br4923          LMQSMPAGGTMWAVAASEDEVVSLLG----EGVGIAAINAPESVVISGPQ
TH_4621|M.thermoresistible__bu      LCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPESTVIGGAT
                                    :   :. .* * *:      *  .        * :..  .*   *:.*  

Mflv_0405|M.gilvum_PYR-GCK          EDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAP
MAB_0939|M.abscessus_ATCC_1997      EDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQVQFAAP
MSMEG_0408|M.smegmatis_MC2_155      EDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQFQFAAP
Mvan_1003|M.vanbaalenii_PYR-1       SDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEFESCAARLAYAAP
Rv2048c|M.tuberculosis_H37Rv        NAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRP
Mb2074c|M.bovis_AF2122/97           NAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRP
MMAR_3025|M.marinum_M               DAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAP
MUL_2266|M.ulcerans_Agy99           DAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAP
MAV_2450|M.avium_104                DAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLAIDKP
MLBr_00135|M.leprae_Br4923          AAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKP
TH_4621|M.thermoresistible__bu      DTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEILADLQPMTP
                                          .     :*     : .. * **  ::*:::*:    . .    *

Mflv_0405|M.gilvum_PYR-GCK          TLPLVCNRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM
MAB_0939|M.abscessus_ATCC_1997      TLPLVCNRTGAVLTAQTPIDGQYWRRHSRQPVQFAESVRTVAALGCSVLM
MSMEG_0408|M.smegmatis_MC2_155      TLPLVCNRTGAVLTGQTPLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM
Mvan_1003|M.vanbaalenii_PYR-1       TRPLVCNRTGAVVTGPGVIDAQYWRRHARQPVQFAESVRTLADLGCSVLM
Rv2048c|M.tuberculosis_H37Rv        TIGVISNVTG-QLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFL
Mb2074c|M.bovis_AF2122/97           TIGVISNVTG-QLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFL
MMAR_3025|M.marinum_M               TIGIISNLTG-QLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFL
MUL_2266|M.ulcerans_Agy99           TIGIISNLTG-QLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFL
MAV_2450|M.avium_104                VIPIISNLTG-QPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFL
MLBr_00135|M.leprae_Br4923          QIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFI
TH_4621|M.thermoresistible__bu      TVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQAALEDGFRVFG
                                         .  *.         .  **  :    *:*. : :     *   : 

Mflv_0405|M.gilvum_PYR-GCK          EIGPQPVLTGAAVQVWPEHLAAPR--AIASLRKGVADRRQIADALAAAYI
MAB_0939|M.abscessus_ATCC_1997      EIGPQPVLTGAAVQVWPEHLAPPR--AIVSLRKGVEDRRQIADALASAYV
MSMEG_0408|M.smegmatis_MC2_155      EIGPQPVLTGAAVQVWPEHMAAPR--AVASLRKGVADRRQIADALASAYV
Mvan_1003|M.vanbaalenii_PYR-1       EIGPQPFLIAAALRVWPESAATPR--AIPSLRKGPDARRQLAEAVAAAYI
Rv2048c|M.tuberculosis_H37Rv        EVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEPATLTNAVAQGFV
Mb2074c|M.bovis_AF2122/97           EVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEPATLTNAVAQGFV
MMAR_3025|M.marinum_M               EVGPSSGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSAVAGVFV
MUL_2266|M.ulcerans_Agy99           EVGPSIGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSALAGVFV
MAV_2450|M.avium_104                EVGPSSGLTAAIEETLADAPVV----TVSALRKDRPEPVALVNAVAQGWV
MLBr_00135|M.leprae_Br4923          ESGPSSGLMGAIEQSLAPAEAV----VVSMMGKDRPELASVLGAAGQLFA
TH_4621|M.thermoresistible__bu      ELSPHPLLTRAVEQTARGLDMPVA--ALPAMRREQEMPHGVRTMVGDLFA
                                    * .*   *  :  .            .   : :       :    .  : 

Mflv_0405|M.gilvum_PYR-GCK          GGHKPDFAALHEQR-GVRLELPTYPFQRRRFWPK---SAGMAIDGRVGAS
MAB_0939|M.abscessus_ATCC_1997      SGHRPNFAALQRHP-RRTVELPTYPFQRRRFWPK---SSGTAIEG--GGG
MSMEG_0408|M.smegmatis_MC2_155      GGHRPDFAAVHRQP-RRPVELPTYPFQRRRFWPK---ASSIAVDG---GT
Mvan_1003|M.vanbaalenii_PYR-1       AGHRLDFTGHDGGP-HRRLPLPTYPFQHRSYWPK---TAGIRSDG----S
Rv2048c|M.tuberculosis_H37Rv        TGMDLDWRAVVGEA--QFVELPTYAFQRRRFWLS-GDGVAADAAGLGLAA
Mb2074c|M.bovis_AF2122/97           TGMDLDWRAVVGEA--QFVELPTYAFQRRRFWLS-GDGVAADAASLGLAA
MMAR_3025|M.marinum_M               AGTAVDWRAVVGQS--NFVELPTYAFERRRFWLS-GDAVAADAAGLGLQA
MUL_2266|M.ulcerans_Agy99           AGTAVDWRAVVGQS--HFVELPTYAFERRRFWLS-GDAVPADAAGLGLQA
MAV_2450|M.avium_104                CGMDVDWRGALGTG--HLVDLPTYAFDRRRFWLS-GDGAASDAAGLGLAA
MLBr_00135|M.leprae_Br4923          TGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGTASVSGLGLGS
TH_4621|M.thermoresistible__bu      AGAAVDFAALYPSG--RLVDAPLPTWTRRKLVLS--RENGEQQTRGGCTI
                                     *   :: .         :  *  .: :*    .                

Mflv_0405|M.gilvum_PYR-GCK          AGSGILGSGKD-LASGD-SVYTSRLSVKTQPWLSDHVIYGTVVVPGATYA
MAB_0939|M.abscessus_ATCC_1997      LPSGILGRGED-LASGD-SVYISRLSVRSQPWLSDHVIYGTVVVPGATYA
MSMEG_0408|M.smegmatis_MC2_155      AASGILGSGKD-LASGD-TIYTSRLSVKSQPWLADHVIYGTVVVPGATYA
Mvan_1003|M.vanbaalenii_PYR-1       SGSGLLGSAQD-LASGD-IVHTSRLSVKTQPWLSDHVIYGTVVVPGATYA
Rv2048c|M.tuberculosis_H37Rv        SEHALLGAVIDLPASGG-VVLTGRLSPSVQGWLADHSVAGVTIFPGAGFV
Mb2074c|M.bovis_AF2122/97           SEHALLGAVIDLPASGG-VVLTGRLSPSVQGWLADHSVAGVTIFPGAGFV
MMAR_3025|M.marinum_M               GEHALLGAVVELPASGG-VVLTGRLSLAAQGWLADHAVGGVVIFPGAGFV
MUL_2266|M.ulcerans_Agy99           GEHALLGAVVELPASGG-VVLTGRLSLAAQGWLADHAVGGVVIFPGAGFV
MAV_2450|M.avium_104                GDHALLGAVVELPASGG-VLLTGRLSPASQGWLADHAVGGVVLFPGAGFV
MLBr_00135|M.leprae_Br4923          TEHALLGAVVERPDSGG-VVLTGRLSLANQPWLADHVIGGVVLFPGAGFV
TH_4621|M.thermoresistible__bu      TVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAALPGAAYC
                                        :**       .    :  . *.   * **:** :  .. .*** : 

Mflv_0405|M.gilvum_PYR-GCK          AMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTVHPSVDGE-SKFQ
MAB_0939|M.abscessus_ATCC_1997      AMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQLTLHPLEDGSGSKFQ
MSMEG_0408|M.smegmatis_MC2_155      AMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTLHPADGGSVLSFQ
Mvan_1003|M.vanbaalenii_PYR-1       AMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQLMLHRTDDADGWTFE
Rv2048c|M.tuberculosis_H37Rv        ELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGPDESGVRGVS
Mb2074c|M.bovis_AF2122/97           ELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVS
MMAR_3025|M.marinum_M               ELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVS
MUL_2266|M.ulcerans_Agy99           ELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVS
MAV_2450|M.avium_104                ELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVVVDGPDDSGARAVS
MLBr_00135|M.leprae_Br4923          ELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAVS
TH_4621|M.thermoresistible__bu      EMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVASAVEPGTLEFA
                                     :.: *          :        :           :          . 

Mflv_0405|M.gilvum_PYR-GCK          VHSRPYGERGAE-WALNAEGVVASGVGD---SPAAAGDLEDPVDEAIERL
MAB_0939|M.abscessus_ATCC_1997      VHSRPYGERDVD-WSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERM
MSMEG_0408|M.smegmatis_MC2_155      IHSRPYGERGAD-WSLNAEGTVDTAGSD---PDAAADEQSDPVDEVIERL
Mvan_1003|M.vanbaalenii_PYR-1       VHSRPYGDRDAD-WSRNASGTVAAGVGD-----AAPDAAADPVDNAIERL
Rv2048c|M.tuberculosis_H37Rv        VYSR--GDVGTG-WVLHAEGALRAGSAE-----PTADLAMWPPAGAVP--
Mb2074c|M.bovis_AF2122/97           VYSR--GDVGTG-WVLHAEGALRAGSAE-----PTADLAMWPPAGAVP--
MMAR_3025|M.marinum_M               VYSR--GDAGSD-WVLHAEGSLGSGSPE-----PATDLSTWPPVGAVE--
MUL_2266|M.ulcerans_Agy99           VYSR--GDAGSD-WVLHAEGSLGSGSPE-----PATDLSTWPPVGAVE--
MAV_2450|M.avium_104                VFSR--ADAGAG-WLLHAEGVLRAGSAQ-----PATDLSAWPPVGAVP--
MLBr_00135|M.leprae_Br4923          VYSR--GDQSHGGWLLNAEGLLEVDAAE-----ATVDLSLWPPEGAES--
TH_4621|M.thermoresistible__bu      VETAKDGEHERR--ATAVLGAADDTEPP-----QAHDIDALLAEHPTR--
                                    : :   .:         . *                              

Mflv_0405|M.gilvum_PYR-GCK          NRMRPQELFETFADLELAWGPTWSGSLKSLWLG--EGEAIGDILVGAELA
MAB_0939|M.abscessus_ATCC_1997      ERMRPMELFEIFADLELAWGPTWSGSLKSLWLG--EGEAIGDVLVGEELA
MSMEG_0408|M.smegmatis_MC2_155      ERMRPQDLFETFADLELAWGPTWSGSLKSLWLG--DGEAVGDILVGAELA
Mvan_1003|M.vanbaalenii_PYR-1       TRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVG--TGEAVGDIAVGAELG
Rv2048c|M.tuberculosis_H37Rv        --VEVADGYQQLAERGYGYGPAFRG-LTAMWRR--GDEVFAEVALPADAG
Mb2074c|M.bovis_AF2122/97           --VEVADGYQQLAERGYGYGPAFRG-LTAMWRR--GDEVFAEVALPADAG
MMAR_3025|M.marinum_M               --VENADGYQQLAERGYGYGPAFRG-LNAMWRR--GDEVFAEVALPADAG
MUL_2266|M.ulcerans_Agy99           --VENADGYQQLAERGYGYGPAFRG-LNAMWRR--GDEVFAEVALPADAG
MAV_2450|M.avium_104                --VDLGDGYEQLAERGYRYGPAFRG-LTSMWRR--GDEIFAEVNLPTDAG
MLBr_00135|M.leprae_Br4923          --VDISDAYPQLAERGYAYGPAFQG-LVAIWRR--GSELFAEVVAPT--G
TH_4621|M.thermoresistible__bu      --IEGDELRQWFDQRGVQFGPAFTGLTAARIPEGTVTSVLAEVGLPGQIR
                                          :    : :    :**:: .   :        . ..::       

Mflv_0405|M.gilvum_PYR-GCK          EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQE
MAB_0939|M.abscessus_ATCC_1997      EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKE
MSMEG_0408|M.smegmatis_MC2_155      EQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAE
Mvan_1003|M.vanbaalenii_PYR-1       EHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADPELFLPLRYGRVEVRE
Rv2048c|M.tuberculosis_H37Rv        VSVTGFGVHPVLLDAALHAVVLSAESAERG---QGSVLVPFSWQGVSLHA
Mb2074c|M.bovis_AF2122/97           VSVTGFGVHPVLLDAALHAVVLSAESAERG---QGSVLVPFSWQGVSLHA
MMAR_3025|M.marinum_M               VSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHA
MUL_2266|M.ulcerans_Agy99           VSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHA
MAV_2450|M.avium_104                VSTTGFGVHPVMLDAALHAVMLASDGDDLP---AGSMLVPFSWQRVSLHA
MLBr_00135|M.leprae_Br4923          VVVDGMGMHPALLDAVLHALGLAIENTQAT----TEMRLPFCWRGVSLHA
TH_4621|M.thermoresistible__bu      SQQAPYGIHPALLDACFQSVAAHPDVQGAG----SGLLLPLGVRRLQAFG
                                           :**.::*                      : :*:    :    

Mflv_0405|M.gilvum_PYR-GCK          KMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTVKRAPRE
MAB_0939|M.abscessus_ATCC_1997      KMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPRE
MSMEG_0408|M.smegmatis_MC2_155      KMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRAPRE
Mvan_1003|M.vanbaalenii_PYR-1       RMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGGIREFTVKRAPRE
Rv2048c|M.tuberculosis_H37Rv        AGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASMLARPVTDQ
Mb2074c|M.bovis_AF2122/97           AGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASMLARPVTDQ
MMAR_3025|M.marinum_M               AGASAVRARIAPAG------PSAVSIELSDGLGLPVLSVASMLARPVTDQ
MUL_2266|M.ulcerans_Agy99           AGASAVRARIAPAG------PSAVSIELSDGLGLPVLSVASMLARPVTDQ
MAV_2450|M.avium_104                AGAAAVRARIVPVS------PSAVSIELADGLGLPVLSVASMVARPVTDQ
MLBr_00135|M.leprae_Br4923          GGAGRVRARFTSAG------ADAIAVDIADSAGLPVLTVRSLVTRAMTAE
TH_4621|M.thermoresistible__bu      PTRGARYCYARVTDAD--GSKAEADLDVLDEHGNVLLRVQGLLMGGAAAD
                                           .                 ::  *  *  :  :  :     . :

Mflv_0405|M.gilvum_PYR-GCK          ALLRGLGGDA---TRLLYTLGWHEVPVP----ESGDGAAPQGTWLIGGFD
MAB_0939|M.abscessus_ATCC_1997      ALLRGLGGDA---TRLLYTLGWHEVAVPPVAGEGEESAASIGTWLIAGFD
MSMEG_0408|M.smegmatis_MC2_155      ALLRGLGGDA---TRLLYTLGWHEVPPP------PSADDAVGTWLIAGFD
Mvan_1003|M.vanbaalenii_PYR-1       ALLRGLGADA---TRLIYRVGWRETSPP---VRDDGALGPSSTWLVAGLD
Rv2048c|M.tuberculosis_H37Rv        QLRAAVSSSG---PDRLFEVTWSPQPSA-------AVEP----LPVCAWG
Mb2074c|M.bovis_AF2122/97           QLRAAVSSSG---PDRLFEVTWSPQPSA-------AVEP----LPVCAWG
MMAR_3025|M.marinum_M               QLRAAVSGAG---PDRLFGVDWTAQPSA-------ELQP----VPVRIWG
MUL_2266|M.ulcerans_Agy99           QLRAAVSGAG---PDRLFGVDWTAQPSA-------ELQP----VPVRIWG
MAV_2450|M.avium_104                QLLAAVSNSG---PDRLFELIWSAQPST-------AVQP----VSLLNWG
MLBr_00135|M.leprae_Br4923          QLRTAVTAAGGALEQGPMDLVWSPIPLS-------SDGHGGGLPSVVSWA
TH_4621|M.thermoresistible__bu      GDDRDRVLGER-----LLTIEWQRRDLP-------EADSAAGKWLLVSTS
                                                       : *     .                 :    

Mflv_0405|M.gilvum_PYR-GCK          ELAVSVPGCIPADR----------------TNPESLRQLLTDAHGRGLPF
MAB_0939|M.abscessus_ATCC_1997      ELAAKVPGCIPLNRE---------------TDPELLGEVLVAAKERGVPF
MSMEG_0408|M.smegmatis_MC2_155      ELAAKVPGCVPIDRN---------------TDLQVLGEVLSQAHARGAGF
Mvan_1003|M.vanbaalenii_PYR-1       ALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFALADERRAPV
Rv2048c|M.tuberculosis_H37Rv        TTEDS---------------------------------------------
Mb2074c|M.bovis_AF2122/97           TTEDS---------------------------------------------
MMAR_3025|M.marinum_M               AVESEGDDDPG---------------------------------------
MUL_2266|M.ulcerans_Agy99           TVESEGDDDPG---------------------------------------
MAV_2450|M.avium_104                ATELDATDTDSDSGR-----------------------------------
MLBr_00135|M.leprae_Br4923          DYCAGRGNDTG---------------------------------------
TH_4621|M.thermoresistible__bu      ATADVSATRLSDALKQAG----------AESTSMCWPQQADHADNVDRFR
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          SGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQ---GGEVKLP
MAB_0939|M.abscessus_ATCC_1997      SGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLP
MSMEG_0408|M.smegmatis_MC2_155      SGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQ---GPSVKLP
Mvan_1003|M.vanbaalenii_PYR-1       AGVVLGVTGRARPEE-PSADFAARLEAQIRDVLGAVHSLS---ALGAKPA
Rv2048c|M.tuberculosis_H37Rv        AAVVFESVPLAG-------DVVAGVYAATSSVLDVLQSWLT-----RDGA
Mb2074c|M.bovis_AF2122/97           AAVVFESVPLAG-------DVVAGVYAATSSVLDVLQSWLT-----RDGA
MMAR_3025|M.marinum_M               ASVVFESVPQAG-------EVVAGVYAATAAVLEVLRSWLS-----RDGA
MUL_2266|M.ulcerans_Agy99           ASVVFESVPQAG-------EVVAGVYAATAAVLEVLRSWLS-----RDGA
MAV_2450|M.avium_104                FAVLFESAPVAG-------DVVTEVYAATRAVLPVLQSWLA-----RDGA
MLBr_00135|M.leprae_Br4923          -VVVWEFGSASAGAQ-APVDSVAAVYSATHAALQVLQFWFG-----QDRA
TH_4621|M.thermoresistible__bu      AGIADGVTGVVVLTGPKNGNPDDAAARRGSDYVRHLVRITRELAEIDGDA
                                      :                             :  :             .

Mflv_0405|M.gilvum_PYR-GCK          GGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGS
MAB_0939|M.abscessus_ATCC_1997      GGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGS
MSMEG_0408|M.smegmatis_MC2_155      GGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGS
Mvan_1003|M.vanbaalenii_PYR-1       AGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLIAEEPGLRCLLVDLDGS
Rv2048c|M.tuberculosis_H37Rv        GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDSD-A
Mb2074c|M.bovis_AF2122/97           GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDSD-A
MMAR_3025|M.marinum_M               GQLVITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPG-RIVLVDTD-A
MUL_2266|M.ulcerans_Agy99           GQLIITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPG-RIVLVDTD-A
MAV_2450|M.avium_104                GTLVVSTRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDTD-A
MLBr_00135|M.leprae_Br4923          GTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSG-KIVLIDTD-S
TH_4621|M.thermoresistible__bu      PRLFVVTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADD
                                      * : *. .         :   :.: *: *    *..  :   :*    

Mflv_0405|M.gilvum_PYR-GCK          PQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGH----LTVPR
MAB_0939|M.abscessus_ATCC_1997      PEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGH----LTVPR
MSMEG_0408|M.smegmatis_MC2_155      SEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGH----LTLPR
Mvan_1003|M.vanbaalenii_PYR-1       EDAGPALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQ----LAIPR
Rv2048c|M.tuberculosis_H37Rv        PLDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGG----LLVPP
Mb2074c|M.bovis_AF2122/97           PLDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGG----LLVPP
MMAR_3025|M.marinum_M               QLDEHAVAAVLAAG---EPQVLWRNGEVYTARVHGSRAVAG----LLVPP
MUL_2266|M.ulcerans_Agy99           QLDEHAVAAVLAAG---EPQVLWRNGEVYTARVHGSRAVAG----LLVPP
MAV_2450|M.avium_104                PLDADAVAAVLAVG---EPQTLLRNGTVYTARVLGSRAVGA----LLVPP
MLBr_00135|M.leprae_Br4923          AVD---VAVLADLG---ESQLLVRCNTVHAARLS--PAPQL----LALPV
TH_4621|M.thermoresistible__bu      ADLDRVAVQLLGGG--AEDETAWRDGQWYTARLSLSPLRPEERKQAVVDC
                                           . :       * :   * .   ..*:              :  

Mflv_0405|M.gilvum_PYR-GCK          GGD-YVLAPTERGAIDNLRLTDS-EVPPPAE-GYVQVRVEAAGLNFRDVL
MAB_0939|M.abscessus_ATCC_1997      GSD-YVLAPTERGAIDNLRITEK-EVPAPDE-GYVQVRVEAAGLNFRDVL
MSMEG_0408|M.smegmatis_MC2_155      GGD-FVLAPTERGAIDNLRLTET-DVPEPDE-GYVQVRVEAAGLNFRDVL
Mvan_1003|M.vanbaalenii_PYR-1       GTD-YVLAPTERGVLDNLRVSET-EVTAPPE-GHVQVRVEAAGLNFRDVL
Rv2048c|M.tuberculosis_H37Rv        SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVM
Mb2074c|M.bovis_AF2122/97           SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVM
MMAR_3025|M.marinum_M               GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM
MUL_2266|M.ulcerans_Agy99           GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM
MAV_2450|M.avium_104                EDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSALAANFRDVM
MLBr_00135|M.leprae_Br4923          GESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVV
TH_4621|M.thermoresistible__bu      ERDGMRLEIRTPGDLETMELAAFDRVPPGPG--QIEVAVTASSINFADVL
                                          *     * :: : :     .        :.*   * . ** **:

Mflv_0405|M.gilvum_PYR-GCK          NVLGLYPGDPG---PIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFA-
MAB_0939|M.abscessus_ATCC_1997      NVLGLYPGDPG---PIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFG-
MSMEG_0408|M.smegmatis_MC2_155      NVLGLYPGDPG---PIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFA-
Mvan_1003|M.vanbaalenii_PYR-1       NALGLYPGDPG---PIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFA-
Rv2048c|M.tuberculosis_H37Rv        IALGLYPDPDA---VMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG-
Mb2074c|M.bovis_AF2122/97           IALGLYPDPDA---VMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG-
MMAR_3025|M.marinum_M               IALGLYPDPDA---AMGVEGAGVVVETASTDGRFAVGDRVVGLFPEGTG-
MUL_2266|M.ulcerans_Agy99           IALGLYPDPDA---AMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGTG-
MAV_2450|M.avium_104                IALGLYPDPDA---VMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTG-
MLBr_00135|M.leprae_Br4923          AALGMYPGQAP---PLGAEGAGVVIEIGPEVTGVAVGDAVMG-FLGGAG-
TH_4621|M.thermoresistible__bu      IAFGRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWS
                                     .:* **        :* : .* *   .       :*: * *    .   

Mflv_0405|M.gilvum_PYR-GCK          SRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRLSF-DWAQVKSGDKVLI
MAB_0939|M.abscessus_ATCC_1997      SRFNVPAQFLAPIPDGISGVEAATIPAAALTVRLSF-DWAQLKPGDKVLI
MSMEG_0408|M.smegmatis_MC2_155      SRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAF-DWAQLKPGDKVLI
Mvan_1003|M.vanbaalenii_PYR-1       SRVNVPVQFLAPVPEGISAVAAATTPAAVLTAGLAF-DWAALRAGDRVLI
Rv2048c|M.tuberculosis_H37Rv        TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLI
Mb2074c|M.bovis_AF2122/97           TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLADVQPGQRVLI
MMAR_3025|M.marinum_M               TIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV
MUL_2266|M.ulcerans_Agy99           TIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV
MAV_2450|M.avium_104                TVATTDQRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLV
MLBr_00135|M.leprae_Br4923          PLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLI
TH_4621|M.thermoresistible__bu      TFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLI
                                    .       : . :* *     **: ...  *.  .: * *   .*: :*:

Mflv_0405|M.gilvum_PYR-GCK          HAASGGVGLAAVQMAQQCGAEVYATAST-FKRATLRKLG--VKHVYDSRT
MAB_0939|M.abscessus_ATCC_1997      HAASGGVGLAAIQMAQQFGAEVFATAST-FKRATLRKLG--VKYVYDSRT
MSMEG_0408|M.smegmatis_MC2_155      HAASGGVGLAAIQMAQQSGAEVFATAST-FKRSTLRRLG--VKYVYDSRT
Mvan_1003|M.vanbaalenii_PYR-1       HAASGGVGLAAVQLARQRGATVFATASG-YKRPMLRAMG--VDHVYDSRT
Rv2048c|M.tuberculosis_H37Rv        HAGTGGVGMAAVQLARHLGLEVFATASK-GKWDTLRAMGFDDDHISDSRS
Mb2074c|M.bovis_AF2122/97           HAGTGGVGMAAVQLARHLGLEVFATASK-GKWDTLRAMGFDDDHISDSRS
MMAR_3025|M.marinum_M               HAATGGVGMAAVQLARHWGLEVFATASK-GKWDTLRAMGFDEDHIGDSRS
MUL_2266|M.ulcerans_Agy99           HAATGGVGMAAVQLARHWGLEVFATASK-GKWDTLRAMGFDEDHIGDSRS
MAV_2450|M.avium_104                HAAAGGVGMAAVQLARHLGLEVFATASR-GKWDTLRDMGFDDDHLGDSRG
MLBr_00135|M.leprae_Br4923          HAGTGGVGMAAVQFARHWGVEIFVTASR-GKWDTLRDMGFDDDHIGDSRT
TH_4621|M.thermoresistible__bu      HSATGGVGLAAIAIARSVGAQIYATAGSPARRDLLRDMG--IEHVYDSRS
                                    *:.:****:**: :*:  *  ::.**.   :   ** :*   .:: *** 

Mflv_0405|M.gilvum_PYR-GCK          TDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDI
MAB_0939|M.abscessus_ATCC_1997      TDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDI
MSMEG_0408|M.smegmatis_MC2_155      TDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDI
Mvan_1003|M.vanbaalenii_PYR-1       TDFADQILADTDGAGVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDI
Rv2048c|M.tuberculosis_H37Rv        LEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI
Mb2074c|M.bovis_AF2122/97           LEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI
MMAR_3025|M.marinum_M               LEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI
MUL_2266|M.ulcerans_Agy99           LEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI
MAV_2450|M.avium_104                LDFEDKFRAVTGGAGMDIVLDSLSGD-SVDASLRLVAPGGIFLEMGKTDI
MLBr_00135|M.leprae_Br4923          LEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDI
TH_4621|M.thermoresistible__bu      TAFADEIRRDTDGYGVDVVLNSLPGA-AQRAGLELLSFGGRFIEIGKRDI
                                      * :::   *.* *.*:**:**..     * :.     * * *:.* **

Mflv_0405|M.gilvum_PYR-GCK          WTVEQMAAA--RPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWT
MAB_0939|M.abscessus_ATCC_1997      WTTEQMAQS--RPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWT
MSMEG_0408|M.smegmatis_MC2_155      WSHEQMAEA--RPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWT
Mvan_1003|M.vanbaalenii_PYR-1       WSPEQMAAA--RPDIDYEVLALDAVMQQDPDRIQLLLADLADSLARGETA
Rv2048c|M.tuberculosis_H37Rv        RDPGVIAQQ--YPGVRYRAFDLFEPG---PDRIAQILAELATLFGDGVLR
Mb2074c|M.bovis_AF2122/97           RDPGVIAQQ--YPGVRYRAFDLFEAG---PDRIAQILAELATLFGDGVLR
MMAR_3025|M.marinum_M               REAAVVAQQ--HTGVRYRAFDLFEAG---PDHIAQILAELAALFSEDALR
MUL_2266|M.ulcerans_Agy99           REAAVVAQQ--HTGVRYRAFDLFEAG---PDHIAQILAELAALFSEDVLR
MAV_2450|M.avium_104                RDPEVVAAE--HPGVRYRAFDLFEAG---PDRIARLLDELAAMFGEDVLR
MLBr_00135|M.leprae_Br4923          RDAQEIAAN--YPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQVLH
TH_4621|M.thermoresistible__bu      YGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYRLTADGVLP
                                         :.      .: :. . *       * ::  :*  :          

Mflv_0405|M.gilvum_PYR-GCK          PLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNP-LQPQPDRSYLITGG
MAB_0939|M.abscessus_ATCC_1997      PLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNP-LAPRPDRTYLITGG
MSMEG_0408|M.smegmatis_MC2_155      PLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKP-LQPQQDRSYLITGG
Mvan_1003|M.vanbaalenii_PYR-1       PLPFEAYPLAEATTAFRRMQQARHTGKIILQMPKP-LQPHGDRSYLITGG
Rv2048c|M.tuberculosis_H37Rv        PLPVTTFDVRCAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGG
Mb2074c|M.bovis_AF2122/97           PLPVTTFDVRRAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGG
MMAR_3025|M.marinum_M               PLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGG
MUL_2266|M.ulcerans_Agy99           PLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGG
MAV_2450|M.avium_104                PLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITGA
MLBr_00135|M.leprae_Br4923          RLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGA
TH_4621|M.thermoresistible__bu      MPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVP-----------------
                                          : :  * :*:* :. *.* **::  :*                 

Mflv_0405|M.gilvum_PYR-GCK          LGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHV
MAB_0939|M.abscessus_ATCC_1997      LGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHV
MSMEG_0408|M.smegmatis_MC2_155      LGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHT
Mvan_1003|M.vanbaalenii_PYR-1       LGALG-LHAAAYLAQLGAGDIVLTGRRMPDAATERAISEIAERYHCRIHT
Rv2048c|M.tuberculosis_H37Rv        TGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQV
Mb2074c|M.bovis_AF2122/97           TGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQV
MMAR_3025|M.marinum_M               TGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQV
MUL_2266|M.ulcerans_Agy99           TGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQV
MAV_2450|M.avium_104                TGMAGSAVARHVVTRHGARNLVLVSRRGLDAPDAAELVAELTAAGAHAEV
MLBr_00135|M.leprae_Br4923          SGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGAVELAAELVGAGAKIQV
TH_4621|M.thermoresistible__bu      --------------HTGRADVVVPPEQASPFRSDGAYIVTGGMGGLGLYL
                                                    *  .:*:  .:                       

Mflv_0405|M.gilvum_PYR-GCK          FTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRT
MAB_0939|M.abscessus_ATCC_1997      FTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRT
MSMEG_0408|M.smegmatis_MC2_155      YAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRT
Mvan_1003|M.vanbaalenii_PYR-1       FAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQQSPERFRT
Rv2048c|M.tuberculosis_H37Rv        VACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDV
Mb2074c|M.bovis_AF2122/97           VACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDV
MMAR_3025|M.marinum_M               VACDAADRAALAKLIADIPVQHP-LSAVIHTAGALDDAVVTSLTPERMET
MUL_2266|M.ulcerans_Agy99           VACDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVVTSLTPERIET
MAV_2450|M.avium_104                VACDAADREALAKVIADIPMQHP-LTGVIHAAGVLDDAVVTSLTPQRIDT
MLBr_00135|M.leprae_Br4923          VACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDT
TH_4621|M.thermoresistible__bu      AGEMAAAGAGCIVLNGRSAPSGEALRTIEQLRAAGTEVIVECGXXXRGQP
                                        ..       :      .   :  : :  ..  :  :      *   

Mflv_0405|M.gilvum_PYR-GCK          ALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLD
MAB_0939|M.abscessus_ATCC_1997      TLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLD
MSMEG_0408|M.smegmatis_MC2_155      TLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLD
Mvan_1003|M.vanbaalenii_PYR-1       TLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANYATANAVLD
Rv2048c|M.tuberculosis_H37Rv        VLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD
Mb2074c|M.bovis_AF2122/97           VLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD
MMAR_3025|M.marinum_M               VLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLD
MUL_2266|M.ulcerans_Agy99           VLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLD
MAV_2450|M.avium_104                VLRAKVDAAWNLHELTRDLDVGAFVMFSSIAGLAGASGQGNYAAGNSFLD
MLBr_00135|M.leprae_Br4923          VLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLD
TH_4621|M.thermoresistible__bu      VEVAVPTELRHADEHPD----------RRGAQLCDEFARGEQGAQRNQHR
                                    .  .        .. .              :   .  .:.: .: .    

Mflv_0405|M.gilvum_PYR-GCK          GLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANIS---AQGLIPLEPS
MAB_0939|M.abscessus_ATCC_1997      GLIAQRRAQGLPATGINFGPWGQGGMASSEAATANIS---AQGLIPLDPS
MSMEG_0408|M.smegmatis_MC2_155      GLVAKRRAQGLVATGINFGPWGQGGMASSEAATANIT---AQGLIPLDPS
Mvan_1003|M.vanbaalenii_PYR-1       GLVAHRKARGLPATGVNWGPWAQGGMATSDAARANLG---AQGLIPLEPT
Rv2048c|M.tuberculosis_H37Rv        ALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSA
Mb2074c|M.bovis_AF2122/97           ALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIVAMSSA
MMAR_3025|M.marinum_M               GLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSD
MUL_2266|M.ulcerans_Agy99           GLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSD
MAV_2450|M.avium_104                GLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARFGRDGIVAMSSQ
MLBr_00135|M.leprae_Br4923          GLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPA
TH_4621|M.thermoresistible__bu      TDAGEGQRDAHPPGAVGHDQPDPGALSDTGLDERGGQFPGVGVQIPVADP
                                          :  .    .:  .     .         .          .:   

Mflv_0405|M.gilvum_PYR-GCK          AALTAMAEVVANGTAQATVLKANWQR-AAKVLGSSRPPILDLVLPSAVGE
MAB_0939|M.abscessus_ATCC_1997      AALAALAEVVANGTGQATILKANWQR-AAKVLGSSRPPILDLVLPSAVGE
MSMEG_0408|M.smegmatis_MC2_155      AALHALAEVIANGSGQATVLKANWQR-AAKVLGSARPPILDLVLPSAAGE
Mvan_1003|M.vanbaalenii_PYR-1       AALNALGEIVAHGIASAVVLKANWQR-AAKLLGATRPPILDHVLPSAVAA
Rv2048c|M.tuberculosis_H37Rv        DALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRR
Mb2074c|M.bovis_AF2122/97           DALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRR
MMAR_3025|M.marinum_M               EALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRR
MUL_2266|M.ulcerans_Agy99           EALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRR
MAV_2450|M.avium_104                EALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVDLINAPTRR
MLBr_00135|M.leprae_Br4923          QALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRR
TH_4621|M.thermoresistible__bu      GVGIDHRGAVRVDSGVPAQQGVDGEVVRHRTLSSVRSGRSSRWTAPGSRC
                                     .       :  .         :      :  ..  .             

Mflv_0405|M.gilvum_PYR-GCK          ITGDS--------ELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPA
MAB_0939|M.abscessus_ATCC_1997      VTGDS--------ELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPPA
MSMEG_0408|M.smegmatis_MC2_155      ATGDS--------ELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPPA
Mvan_1003|M.vanbaalenii_PYR-1       GPGDS--------ALLKQLQDVPEAQRGSFVTEHLQRELQQILGLAQPPA
Rv2048c|M.tuberculosis_H37Rv        QVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEA
Mb2074c|M.bovis_AF2122/97           QVDDSLAAAKSKSALAHRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEA
MMAR_3025|M.marinum_M               QVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDA
MUL_2266|M.ulcerans_Agy99           QVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDA
MAV_2450|M.avium_104                QVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEA
MLBr_00135|M.leprae_Br4923          QIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPED
TH_4621|M.thermoresistible__bu      G-------------SGRRYGGESCRRTTGPAAGAAARRGRTRRRRRPRRP
                                                    ::    .  .           .            

Mflv_0405|M.gilvum_PYR-GCK          ATS--RFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAE
MAB_0939|M.abscessus_ATCC_1997      ATS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAE
MSMEG_0408|M.smegmatis_MC2_155      ASS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAE
Mvan_1003|M.vanbaalenii_PYR-1       ATG--RFLELGMDSLMAVELRNRLVGQFGSGFTITATAVFDYPTIGALAE
Rv2048c|M.tuberculosis_H37Rv        IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG
Mb2074c|M.bovis_AF2122/97           IDPDRAFQDLGFDSLTAVEMRNRLKSATG--LSLSPTLIFDYPNSAALAG
MMAR_3025|M.marinum_M               IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG
MUL_2266|M.ulcerans_Agy99           IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG
MAV_2450|M.avium_104                IHPDRAFQELGFDSLTAVEMRNRLKAATG--LALSPTLIFDYPNSAALAG
MLBr_00135|M.leprae_Br4923          IDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLPPTVIFDHPTPTAVAE
TH_4621|M.thermoresistible__bu      PPPPDRVRHRAGPAHGPVRR------------------------------
                                          . . .  :  .:.                               

Mflv_0405|M.gilvum_PYR-GCK          YLVAQLPDAETP-------------------------------------Q
MAB_0939|M.abscessus_ATCC_1997      YLVGQLPDADAE-------------------------------------S
MSMEG_0408|M.smegmatis_MC2_155      YLVGQLPDAEAP-------------------------------------E
Mvan_1003|M.vanbaalenii_PYR-1       YLAAQTPESTEE-------------------------------------G
Rv2048c|M.tuberculosis_H37Rv        YMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALA
Mb2074c|M.bovis_AF2122/97           YMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALA
MMAR_3025|M.marinum_M               YMHRELVGASPQSDITAEAPGEAELQRVVASIPVKRLRQAGVLELLLALA
MUL_2266|M.ulcerans_Agy99           YMHRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQAGVLELLLALA
MAV_2450|M.avium_104                YMYRELVGTSEQ-PTAAAAPGEAEIQRVVGSIPVKRLRQAGVLELLLALA
MLBr_00135|M.leprae_Br4923          YVAQQMLKSRPA--------------------------------------
TH_4621|M.thermoresistible__bu      --------------------------------------------------
                                                                                      

Mflv_0405|M.gilvum_PYR-GCK          AAP-------QSESEPGPDVTE-----------------
MAB_0939|M.abscessus_ATCC_1997      AEAPPAVESAEAESGAGPAAASDAVSELKE---------
MSMEG_0408|M.smegmatis_MC2_155      TA-------------------------------------
Mvan_1003|M.vanbaalenii_PYR-1       TEMKTADPDGQPATVGHADVVLQTS--------------
Rv2048c|M.tuberculosis_H37Rv        NETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE-
Mb2074c|M.bovis_AF2122/97           NETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE-
MMAR_3025|M.marinum_M               NETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE-
MUL_2266|M.ulcerans_Agy99           NETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE-
MAV_2450|M.avium_104                NESTGTAQSATPAVTTEKDIADMDLDDLVNAALLDDDDE
MLBr_00135|M.leprae_Br4923          -ESGDETSQAVEPKVEEVSVHA-----------------
TH_4621|M.thermoresistible__bu      ---------------------------------------