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VDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEGLWQMVADARDVMSEFP TDRGWDLAGLFDPDPDVRHKSYARTGGFVDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGI DPTGLRGSATGVFAGLIVGGYGMLAEEIEGYRLTGMTSSVASGRVAYVLGLEGPAVSVDTACSSSLVALH MAVGSLRSGECDLALAGGVTVNATPTVFVEFSRHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDA RRLGHPVLAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQ ALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAV ELLTAPRVWPAGARTRRAGVSSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAAR LAAYVRGDDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFV FPGQGSQWLGMGIELLDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGAPGLDRVDVVQPVLFAVMVS LAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLAGLAGPGGMVSIACGADQARDL LAPFGDRVSIAVVNGPSAVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGI EPRSTRTVFFSTVTGNRLDTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESSPHPALITGVEETF AACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAGVAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEG SGADVSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRAGDE VGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRADAQAGWLLHAEGILRPGSVEPGAD LSVWPPAGAVTVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDA VLHAVVIAGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPVLSVASMVARPVTE RQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQSWLTDHE SGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQVVLR GGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAA AISAVFTTAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDH ISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRY RAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTGKVVMLMPGSWAAGT VLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKV IADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALEL FDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQ HAVLLGLVRLHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLA SYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLA GLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS ATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLVALHMAVGSLR SGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPV LAVVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG QDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPR VWPAGARTRRAGVSSFGISGTNAHVIIEAVPVVPRREAGWAGPVVPWVVSAKSESALRGQAARLAAYVRG DDGLDVADVGWSLAGRSVFEHRAVVVGGDRDRLLAGLDELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQ WLGMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENLLNSTEFAQPALFAVEVALFRLLGSW GVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAEVDIA AVNGPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRPTIGVIS NVTGQLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVTTMSAL RKDRPEPATLTNAVAQGFVTGMDLDWRAVVGEAQFVELPTYAFQRRRFWLSGDGVAADAAGLGLAASEHA LLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAGVTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLV LPASGSVAVQVVVNGPDESGVRGVSVYSRGDVGTGWVLHAEGALRAGSAEPTADLAMWPPAGAVPVEVAD GYQQLAERGYGYGPAFRGLTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDAALHAVVLSAESAERG QGSVLVPFSWQGVSLHAAGASAVRARIAPVGPSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSS GPDRLFEVTWSPQPSAAVEPLPVCAWGTTEDSAAVVFESVPLAGDVVAGVYAATSSVLDVLQSWLTRDGA GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDSDAPLDDSALAAVVTTGEPQVLWRR GEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDV MIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGTVASTDQRLLVKVPAGWSHTAAA TTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDH ISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRY RAFDLFEPGPDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAALRYLSQARHTGKVVMLMPGSWAAGT VLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKV IADIPVQHPLSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVG SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADALQL FDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPED EQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLTAVEMRNRLKSATGLALSPTLIFDYPNSAA LAGYMRRELLGSSPQDTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALANETETSGQDPALAPTAEQ EIADMDLDDLVNAAFRNDDE*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv2048c | pks12 | - | 100% (4151) | Probable polyketide synthase pks12 |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 61.04% (2056) | polyketide synthase pks7 |
M. tuberculosis H37Rv | Rv1662 | pks8 | 0.0 | 59.43% (1607) | polyketide synthase pks8 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2074c | pks12 | 0.0 | 99.42% (4151) | polyketide synthase pks12 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 37.06% (2542) | beta-ketoacyl synthase |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 58.21% (2082) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 35.81% (2547) | polyketide synthase |
M. marinum M | MMAR_3025 | pks12 | 0.0 | 83.19% (4188) | polyketide synthase, Pks12 |
M. avium 104 | MAV_2450 | - | 0.0 | 80.90% (4177) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 36.18% (2521) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 34.95% (1874) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 82.78% (4192) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 37.21% (2548) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK -----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG- MAB_0939|M.abscessus_ATCC_1997 -----------------------MDSAENPIE-STPRFAIIGYAARFPG- MSMEG_0408|M.smegmatis_MC2_155 -----------------------MVSAEHPIE-PTPSFAIIGYAARFPG- Mvan_1003|M.vanbaalenii_PYR-1 ---------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG- Rv2048c|M.tuberculosis_H37Rv -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG Mb2074c|M.bovis_AF2122/97 -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MMAR_3025|M.marinum_M -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MUL_2266|M.ulcerans_Agy99 -MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGG MAV_2450|M.avium_104 MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF MAB_0939|M.abscessus_ATCC_1997 AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF MSMEG_0408|M.smegmatis_MC2_155 AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF Mvan_1003|M.vanbaalenii_PYR-1 AADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGF Rv2048c|M.tuberculosis_H37Rv VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF Mb2074c|M.bovis_AF2122/97 VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF MMAR_3025|M.marinum_M VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF MUL_2266|M.ulcerans_Agy99 VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF MAV_2450|M.avium_104 VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT MAB_0939|M.abscessus_ATCC_1997 VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET MSMEG_0408|M.smegmatis_MC2_155 VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS Mvan_1003|M.vanbaalenii_PYR-1 VEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGT Rv2048c|M.tuberculosis_H37Rv VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS Mb2074c|M.bovis_AF2122/97 VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS MMAR_3025|M.marinum_M VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS MUL_2266|M.ulcerans_Agy99 VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS MAV_2450|M.avium_104 VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ MAB_0939|M.abscessus_ATCC_1997 NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ MSMEG_0408|M.smegmatis_MC2_155 NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ Mvan_1003|M.vanbaalenii_PYR-1 RTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQ Rv2048c|M.tuberculosis_H37Rv ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE Mb2074c|M.bovis_AF2122/97 ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE MMAR_3025|M.marinum_M ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE MUL_2266|M.ulcerans_Agy99 ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE MAV_2450|M.avium_104 ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS MAB_0939|M.abscessus_ATCC_1997 GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS Mvan_1003|M.vanbaalenii_PYR-1 GPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFS Rv2048c|M.tuberculosis_H37Rv GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS Mb2074c|M.bovis_AF2122/97 GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS MMAR_3025|M.marinum_M GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MUL_2266|M.ulcerans_Agy99 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MAV_2450|M.avium_104 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR MAB_0939|M.abscessus_ATCC_1997 HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR MSMEG_0408|M.smegmatis_MC2_155 NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR Mvan_1003|M.vanbaalenii_PYR-1 RARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIR Rv2048c|M.tuberculosis_H37Rv RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV Mb2074c|M.bovis_AF2122/97 RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV MMAR_3025|M.marinum_M RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR MUL_2266|M.ulcerans_Agy99 RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR MAV_2450|M.avium_104 RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS MAB_0939|M.abscessus_ATCC_1997 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS MSMEG_0408|M.smegmatis_MC2_155 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS Mvan_1003|M.vanbaalenii_PYR-1 GSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTP Rv2048c|M.tuberculosis_H37Rv GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT Mb2074c|M.bovis_AF2122/97 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MMAR_3025|M.marinum_M GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MUL_2266|M.ulcerans_Agy99 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MAV_2450|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LGDPIEAQAAGAALGPGREPQ----RPLLIGSAKTNIGHLEAAAGIAGVI MAB_0939|M.abscessus_ATCC_1997 LGDPIEAQAAGAAYGIGRETN----DPLLIGSAKTNIGHLEAAAGIAGVI MSMEG_0408|M.smegmatis_MC2_155 LGDPIEAQAAGEVLGAGRAPE----EPLLIGSAKTNIGHLEAAAGIAGVI Mvan_1003|M.vanbaalenii_PYR-1 LGDPIEVQAAGAVLGVGREPD----RPLLIGSVKTNIGHLEAASGIAGLL Rv2048c|M.tuberculosis_H37Rv LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI Mb2074c|M.bovis_AF2122/97 LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI MMAR_3025|M.marinum_M LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI MUL_2266|M.ulcerans_Agy99 LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI MAV_2450|M.avium_104 LGDPIEAQALLATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPR MAB_0939|M.abscessus_ATCC_1997 KVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPR MSMEG_0408|M.smegmatis_MC2_155 KVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPR Mvan_1003|M.vanbaalenii_PYR-1 KVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSR Rv2048c|M.tuberculosis_H37Rv KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR Mb2074c|M.bovis_AF2122/97 KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR MMAR_3025|M.marinum_M KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR MUL_2266|M.ulcerans_Agy99 KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR MAV_2450|M.avium_104 KMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTP MAB_0939|M.abscessus_ATCC_1997 IAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTP MSMEG_0408|M.smegmatis_MC2_155 IAGVSSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTP Mvan_1003|M.vanbaalenii_PYR-1 VAGISSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTP Rv2048c|M.tuberculosis_H37Rv RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE Mb2074c|M.bovis_AF2122/97 RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE MMAR_3025|M.marinum_M RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG MUL_2266|M.ulcerans_Agy99 RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG MAV_2450|M.avium_104 RAGVSSFGISGTNAHVIIEAVPAVEPAHADAPALPVLP----WVVSAKSA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALMAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAA MAB_0939|M.abscessus_ATCC_1997 AALAQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAA MSMEG_0408|M.smegmatis_MC2_155 EALVRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESA Mvan_1003|M.vanbaalenii_PYR-1 DALAATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSV Rv2048c|M.tuberculosis_H37Rv SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL Mb2074c|M.bovis_AF2122/97 SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL MMAR_3025|M.marinum_M SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGVDRDGL MUL_2266|M.ulcerans_Agy99 SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRDGL MAV_2450|M.avium_104 AALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGGDRDRL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTE MAB_0939|M.abscessus_ATCC_1997 VELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETE MSMEG_0408|M.smegmatis_MC2_155 IELLGALADDRPA-PGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTE Mvan_1003|M.vanbaalenii_PYR-1 EELLGALAEDRPG-PGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTE Rv2048c|M.tuberculosis_H37Rv LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA Mb2074c|M.bovis_AF2122/97 LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA MMAR_3025|M.marinum_M LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA MUL_2266|M.ulcerans_Agy99 LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA MAV_2450|M.avium_104 LAGLDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPA MAB_0939|M.abscessus_ATCC_1997 PVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPA MSMEG_0408|M.smegmatis_MC2_155 PVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPA Mvan_1003|M.vanbaalenii_PYR-1 PVYREVMTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPA Rv2048c|M.tuberculosis_H37Rv PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV Mb2074c|M.bovis_AF2122/97 PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV MMAR_3025|M.marinum_M PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRVDVVQPV MUL_2266|M.ulcerans_Agy99 PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRIDVVQPV MAV_2450|M.avium_104 PVFAQHIQACEEAFAEFVDWSLIDALRGAP------GAAGMDRVDVVQPA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAE MAB_0939|M.abscessus_ATCC_1997 LFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAE MSMEG_0408|M.smegmatis_MC2_155 LFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAE Mvan_1003|M.vanbaalenii_PYR-1 LYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAE Rv2048c|M.tuberculosis_H37Rv LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL Mb2074c|M.bovis_AF2122/97 LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL MMAR_3025|M.marinum_M LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL MUL_2266|M.ulcerans_Agy99 LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL MAV_2450|M.avium_104 LFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RGRLFGSLPSGGRMAAVFAAAERVEALTDEY-PALSVAAYNG-ANTVLSG MAB_0939|M.abscessus_ATCC_1997 RGRLFSSLPAGGRMAAVFTDAERAERLTDEF-PSLSVAAYNG-ANTVLSG MSMEG_0408|M.smegmatis_MC2_155 RGRLFGSLPAGGRMAAVFTAPERAERLTDEY-PSLSVAAYNG-ANTVLSG Mvan_1003|M.vanbaalenii_PYR-1 RGRLFGSLPEGGRMAAVFAPADRVESCTVDS-PLLSVAAYNG-DNTVLSG Rv2048c|M.tuberculosis_H37Rv RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG Mb2074c|M.bovis_AF2122/97 RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG MMAR_3025|M.marinum_M RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG MUL_2266|M.ulcerans_Agy99 RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG MAV_2450|M.avium_104 RSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFT MAB_0939|M.abscessus_ATCC_1997 PAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYK MSMEG_0408|M.smegmatis_MC2_155 PAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYR Mvan_1003|M.vanbaalenii_PYR-1 PAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFG Rv2048c|M.tuberculosis_H37Rv EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR Mb2074c|M.bovis_AF2122/97 EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR MMAR_3025|M.marinum_M EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL MUL_2266|M.ulcerans_Agy99 EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL MAV_2450|M.avium_104 EGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK APQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKL MAB_0939|M.abscessus_ATCC_1997 TPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKV MSMEG_0408|M.smegmatis_MC2_155 EPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRV Mvan_1003|M.vanbaalenii_PYR-1 TPQRTLVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVRTLADLGCRL Rv2048c|M.tuberculosis_H37Rv STRTVFFSTVTGNRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQGYRT Mb2074c|M.bovis_AF2122/97 STRTVFFSTVTGNRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQGYRT MMAR_3025|M.marinum_M SSRTAFFSSVTGSRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGHGYRT MUL_2266|M.ulcerans_Agy99 SSRTAFFSSVTGSRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGHGYRT MAV_2450|M.avium_104 SSRIAFFSTVTGNRLD-TAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVEIGPRPVLTAAALSAWP----DPATSPRVIASLRRTTADQRQITEAVA MAB_0939|M.abscessus_ATCC_1997 LLEIGPQPVLTAAALRAWP----DPATAPRAIASLRRNTADHRQITEAAA MSMEG_0408|M.smegmatis_MC2_155 LLEIGPRPVLTATALAAWP----DPATTPQVLASLRPTTADHRQITEAVA Mvan_1003|M.vanbaalenii_PYR-1 LMEIGPQPVLTAAAMRTWP----GTVTAPRVAASMRRKGSDRRQITEALA Rv2048c|M.tuberculosis_H37Rv FIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFLLSAA Mb2074c|M.bovis_AF2122/97 FIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFLLSAA MMAR_3025|M.marinum_M FIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA MUL_2266|M.ulcerans_Agy99 FIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA MAV_2450|M.avium_104 FIESSPHPALVAGIEDTVNDSLPGD-TEAIVIPTLGRDDGGLERFLTSAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDSRE---PVAAAP MAB_0939|M.abscessus_ATCC_1997 DAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGDNRDAGNR MSMEG_0408|M.smegmatis_MC2_155 AAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTAS Mvan_1003|M.vanbaalenii_PYR-1 QAYVAGHRPETAARQHGRGRLLDLPTYPFQHRAYWFP--------QGQAR Rv2048c|M.tuberculosis_H37Rv SAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGL Mb2074c|M.bovis_AF2122/97 SAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGL MMAR_3025|M.marinum_M AAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDASGLGL MUL_2266|M.ulcerans_Agy99 AAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDASGLGL MAV_2450|M.avium_104 TAFVAGVNVAWRGVLDG-AGFVELPTYAFDRRRFWLSGEGAAADASGLGL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QR---GARTETVRLLEDGRIEELAALLGGTV------------------- MAB_0939|M.abscessus_ATCC_1997 QQNNGGPRTEAVRLLEDGKIEELANLLGGVD------------------- MSMEG_0408|M.smegmatis_MC2_155 AGSVTPHRTQAVRLLEDGQIEELAALIDGET------------------- Mvan_1003|M.vanbaalenii_PYR-1 TAPTDPVHTETVRFLDEERIDELAALLDGPT------------------- Rv2048c|M.tuberculosis_H37Rv GASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGF Mb2074c|M.bovis_AF2122/97 GASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGF MMAR_3025|M.marinum_M SAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFPGTGF MUL_2266|M.ulcerans_Agy99 SAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFPGTGF MAV_2450|M.avium_104 GTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFPGAGF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------DDPFTFDVLNRLAAQHNQQRSTE-------------------- MAB_0939|M.abscessus_ATCC_1997 -------GDQQTLNVLTKLAAQHNLQRTTQ-------------------- MSMEG_0408|M.smegmatis_MC2_155 -------VDEQTLRVLNKLAARHNQQRSTH-------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------GSAQTVDVLSKLAARHRQQRGAQ-------------------- Rv2048c|M.tuberculosis_H37Rv VELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSN Mb2074c|M.bovis_AF2122/97 VELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSN MMAR_3025|M.marinum_M VELAIRAGDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAAADSA MUL_2266|M.ulcerans_Agy99 VELAIRAVDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAAADSA MAV_2450|M.avium_104 VELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEADESG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------SIADDRYQIRWETAAEPPVGADAADGITWLLVGDD MAB_0939|M.abscessus_ATCC_1997 ---------------TIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADA MSMEG_0408|M.smegmatis_MC2_155 ---------------VDPDARYEIRWDAIASAAASTGAAA--DWILVGDD Mvan_1003|M.vanbaalenii_PYR-1 ---------------SIADARYQIRWEKSEAPGAARPTTEATTWLLVTHD Rv2048c|M.tuberculosis_H37Rv SRGVSIFSR------ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAV Mb2074c|M.bovis_AF2122/97 SRGVSIFSR------ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAV MMAR_3025|M.marinum_M ERSVSIYSR----TDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAI MUL_2266|M.ulcerans_Agy99 ERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAI MAV_2450|M.avium_104 RRDVSIFSR------PDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGAT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TDATRPLVDVLAARGHRY-------------------------------- MAB_0939|M.abscessus_ATCC_1997 AGAAQPLLDVLTARGQQH-------------------------------- MSMEG_0408|M.smegmatis_MC2_155 TAAVLEFADALTAGGHRH-------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 SRAAQPIAEVLERRGHPY-------------------------------- Rv2048c|M.tuberculosis_H37Rv TVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGG Mb2074c|M.bovis_AF2122/97 TVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGG MMAR_3025|M.marinum_M AVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEVRLPEAAGSTSG MUL_2266|M.ulcerans_Agy99 AVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAGSTSG MAV_2450|M.avium_104 KVDIADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv FGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASAVRAR Mb2074c|M.bovis_AF2122/97 FGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASAVRAR MMAR_3025|M.marinum_M FGVHPALLDAALHTAVI----ANPDAELVLPFSWQGVSLHAAGAASVRVR MUL_2266|M.ulcerans_Agy99 FGVHPALLDAALHTAVI----ANPDADLVLPFSWQGVSLHAAGAASVRVR MAV_2450|M.avium_104 FGVHPALLDAAMHALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRAR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----------------------------RILGLPKSGAEEHELADTLRDA MAB_0939|M.abscessus_ATCC_1997 ----------------------------RVLALPVSDADEAELVEALRSA MSMEG_0408|M.smegmatis_MC2_155 ----------------------------QIVALPGSDADEAQLVDTLRAA Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------HIVGLPGSDADAAPAEEALRAT Rv2048c|M.tuberculosis_H37Rv IAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGS Mb2074c|M.bovis_AF2122/97 IAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGS MMAR_3025|M.marinum_M IAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAVVSAS MUL_2266|M.ulcerans_Agy99 IAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAVVSAS MAV_2450|M.avium_104 LAPAQAPGTAASRAVSLELADGLGLPVLSVRAMVARSVSERQLRAAVSAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQL MAB_0939|M.abscessus_ATCC_1997 ADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAEL MSMEG_0408|M.smegmatis_MC2_155 SAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFRAANDAEL Mvan_1003|M.vanbaalenii_PYR-1 VSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQLAATAGA Rv2048c|M.tuberculosis_H37Rv GPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALA Mb2074c|M.bovis_AF2122/97 GPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALA MMAR_3025|M.marinum_M GPDRLFEVVWTPMTVAAT-DAAPAYELFESVAAEGDPLSGTYQRTHQALA MUL_2266|M.ulcerans_Agy99 GPDRLFEVVWTPMTVAAT-DAAPAYELFESIAADGDPLSGTYQRTHQALA MAV_2450|M.avium_104 GPDRLFEVAWAPVTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHEALA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RSPMWL----------VTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQ MAB_0939|M.abscessus_ATCC_1997 RAPIWI----------VTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQ MSMEG_0408|M.smegmatis_MC2_155 RSPIWL----------VTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPH Mvan_1003|M.vanbaalenii_PYR-1 RAPIWL----------ITAGAQRITGDETVEPAQTSLWGFGRAAALEQPE Rv2048c|M.tuberculosis_H37Rv AVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPG Mb2074c|M.bovis_AF2122/97 AVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPG MMAR_3025|M.marinum_M AVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPG MUL_2266|M.ulcerans_Agy99 AVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPG MAV_2450|M.avium_104 AVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQTEHPG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----------------------------IWGG------------------ MAB_0939|M.abscessus_ATCC_1997 ----------------------------VWGG------------------ MSMEG_0408|M.smegmatis_MC2_155 ----------------------------IWGG------------------ Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------LWGG------------------ Rv2048c|M.tuberculosis_H37Rv RIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILV Mb2074c|M.bovis_AF2122/97 RIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILV MMAR_3025|M.marinum_M RLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILV MUL_2266|M.ulcerans_Agy99 RLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILV MAV_2450|M.avium_104 RIVLIDSDAALDDSALTAALATGEPQVLLRDGTVYTARVHGSRAVDGIMT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------LADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPR MAB_0939|M.abscessus_ATCC_1997 -------LADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPR MSMEG_0408|M.smegmatis_MC2_155 -------LADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPR Mvan_1003|M.vanbaalenii_PYR-1 -------LADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVAR Rv2048c|M.tuberculosis_H37Rv PPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD Mb2074c|M.bovis_AF2122/97 PPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD MMAR_3025|M.marinum_M PPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRD MUL_2266|M.ulcerans_Agy99 PPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRD MAV_2450|M.avium_104 PPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRD MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVHRDTLPSGKPLHLRADA------------------------------- MAB_0939|M.abscessus_ATCC_1997 LVRREELPSGKPLEVRSDA------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LVRRTGEPSDTPLPVREDR------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LTRCAEKANAAALELRREA------------------------------- Rv2048c|M.tuberculosis_H37Rv IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLV Mb2074c|M.bovis_AF2122/97 IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLV MMAR_3025|M.marinum_M IMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLV MUL_2266|M.ulcerans_Agy99 IMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLV MAV_2450|M.avium_104 VMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSGTLV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAG Mb2074c|M.bovis_AF2122/97 AGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAG MMAR_3025|M.marinum_M AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA MUL_2266|M.ulcerans_Agy99 AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA MAV_2450|M.avium_104 PGDVRLLQHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFE Mb2074c|M.bovis_AF2122/97 TGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFE MMAR_3025|M.marinum_M TGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFE MUL_2266|M.ulcerans_Agy99 TGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFE MAV_2450|M.avium_104 AGGVGMAAVQLARHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLEFE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV Mb2074c|M.bovis_AF2122/97 DKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV MMAR_3025|M.marinum_M EKFREVTGGRGVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGV MUL_2266|M.ulcerans_Agy99 EKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGV MAV_2450|M.avium_104 DKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv IAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVR Mb2074c|M.bovis_AF2122/97 IAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVR MMAR_3025|M.marinum_M IAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVR MUL_2266|M.ulcerans_Agy99 IAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVR MAV_2450|M.avium_104 VAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTTFDIR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------------------------TYLVTGGLGSLGLEIAG MAB_0939|M.abscessus_ATCC_1997 ---------------------------------TYLVTGGLGSIGLEIAG MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------TYLVTGGLGAIGLEVAG Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------------TYLVTGGLGALGLEVAE Rv2048c|M.tuberculosis_H37Rv RAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGSAVAR Mb2074c|M.bovis_AF2122/97 RAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGSAVAR MMAR_3025|M.marinum_M RAPAALRYLSQARHIGKVVMTMPADQGGALGGGTVLITGGTGMAGSALAR MUL_2266|M.ulcerans_Agy99 RAPAALRYLSQARHVGKVVMTMPADQGGALGGGTVLITGGTGMAGSALAR MAV_2450|M.avium_104 RGRAALRYLSQARHIGKVVMTVPG----ALSAGTVLITGGTGMAGSTLAR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK YLAA-NGAGHLVLTSRRTPDEAAASRIEALRERHGCEVRVVTADVADAHA MAB_0939|M.abscessus_ATCC_1997 YLAG-RGAKHLVLTSRREPGEAARQRIDALAA-QGCEVRAVTADVADGHD MSMEG_0408|M.smegmatis_MC2_155 YLAS-HGAGHVVLTSRREPGDDARRRLDGLREQYACDVRVITADVADAHD Mvan_1003|M.vanbaalenii_PYR-1 FLAS-HGAGHLVLTGRRSASDTVRQRIDAMRERFDCQVLVATADVADRDD Rv2048c|M.tuberculosis_H37Rv HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAA Mb2074c|M.bovis_AF2122/97 HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAA MMAR_3025|M.marinum_M HLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPA MUL_2266|M.ulcerans_Agy99 HLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPA MAV_2450|M.avium_104 HLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVIACDAADRAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVDRVFAGKVWGAW MAB_0939|M.abscessus_ATCC_1997 VARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAGKVWGAW MSMEG_0408|M.smegmatis_MC2_155 VARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAW Mvan_1003|M.vanbaalenii_PYR-1 VARLFSTMRSELPPLAGIVHAAGEIGTSPLRTLDDAEMDRVFAGKVWGAV Rv2048c|M.tuberculosis_H37Rv LAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAW Mb2074c|M.bovis_AF2122/97 LAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAW MMAR_3025|M.marinum_M LAKVIAEIPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAW MUL_2266|M.ulcerans_Agy99 LAKVIAENPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAW MAV_2450|M.avium_104 LAGVIAGISAERP-LSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAW MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK HLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAANAFLDGLAWRLRE MAB_0939|M.abscessus_ATCC_1997 HLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAANAFLDGLAWRLRE MSMEG_0408|M.smegmatis_MC2_155 HLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFLDGLAWRLRE Mvan_1003|M.vanbaalenii_PYR-1 YLCEEVADMG--LDFFLATSSIASVWGSHGQTAYGAANAFLDGLADSLRA Rv2048c|M.tuberculosis_H37Rv HLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRA Mb2074c|M.bovis_AF2122/97 HLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRA MMAR_3025|M.marinum_M NLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRA MUL_2266|M.ulcerans_Agy99 NLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRA MAV_2450|M.avium_104 NLHELTRDMN--LSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRRA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QGVAGVSVNFGPWS-----AGMADAQSRARLEQRGIKTLSPADALAGLSD MAB_0939|M.abscessus_ATCC_1997 QGIAGTSVNFGPWS-----AGMADAESRARLEQRGIKTLSPTDALAGLAD MSMEG_0408|M.smegmatis_MC2_155 RGVTAVSVNFGPWA-----AGMADAESRARLEQRGVRTLSPAEALAGMAD Mvan_1003|M.vanbaalenii_PYR-1 RGIPGISVNFGPWA-----AGMADAKAREQLSRRGVKTLAPADALAGMAD Rv2048c|M.tuberculosis_H37Rv HGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDT Mb2074c|M.bovis_AF2122/97 HGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALSTAEALELFDT MMAR_3025|M.marinum_M HGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDT MUL_2266|M.ulcerans_Agy99 HGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDT MAV_2450|M.avium_104 HGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGILALSSDEAMELFDT MLBr_00135|M.leprae_Br4923 ------------------MTASVEGADQK--------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQG MAB_0939|M.abscessus_ATCC_1997 VVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLA--G MSMEG_0408|M.smegmatis_MC2_155 VVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAA Mvan_1003|M.vanbaalenii_PYR-1 VIAASTA---HAVVARIDWATFLPVYQLQRRRAFLSQLEREVPDVPD--A Rv2048c|M.tuberculosis_H37Rv AMIVDEP-----FLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDS Mb2074c|M.bovis_AF2122/97 AMIVDEP-----FLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDS MMAR_3025|M.marinum_M ALIVNQA-----FLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQVDDA MUL_2266|M.ulcerans_Agy99 ALIVNQA-----FLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQIDAA MAV_2450|M.avium_104 ALIVDEP-----FLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDA MAB_0939|M.abscessus_ATCC_1997 VAGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDA MSMEG_0408|M.smegmatis_MC2_155 APATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEA Mvan_1003|M.vanbaalenii_PYR-1 SAPAPSGTTRFVEELTLAPVEQRRKLVLEYLRAAVAEVTRVDAAEIRDEA Rv2048c|M.tuberculosis_H37Rv VAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDK Mb2074c|M.bovis_AF2122/97 VAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDK MMAR_3025|M.marinum_M LAAAKSKSALAHRLHGLPEPEQHAVVLDLVRSHIATVLGTITPEAIDPDK MUL_2266|M.ulcerans_Agy99 LATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAIDPDK MAV_2450|M.avium_104 LAAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDK MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYLLGDVL MAB_0939|M.abscessus_ATCC_1997 GFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVL MSMEG_0408|M.smegmatis_MC2_155 GFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLLVEVL Mvan_1003|M.vanbaalenii_PYR-1 GFFDLGMDSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVLGDVL Rv2048c|M.tuberculosis_H37Rv AFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELA Mb2074c|M.bovis_AF2122/97 AFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELA MMAR_3025|M.marinum_M AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELA MUL_2266|M.ulcerans_Agy99 AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELA MAV_2450|M.avium_104 AFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELA MLBr_00135|M.leprae_Br4923 -------------------------------------SEKLISYLKKVVV TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPG-APNPEAFWDLLSGG MAB_0939|M.abscessus_ATCC_1997 GLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPG-APDPEAFWDVLSGG MSMEG_0408|M.smegmatis_MC2_155 GLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPG-APDPESFWELLAGG Mvan_1003|M.vanbaalenii_PYR-1 GLSEHTV--AQPDTPSTVRTDDPIAIVGMACRFPG-ADDTDAFWSVLAEG Rv2048c|M.tuberculosis_H37Rv GLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG Mb2074c|M.bovis_AF2122/97 GLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG MMAR_3025|M.marinum_M GAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR MUL_2266|M.ulcerans_Agy99 GAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR MAV_2450|M.avium_104 GAPQETT----HAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQMVAEG MLBr_00135|M.leprae_Br4923 ELDETRA----RLREYEQRATEPVAVVGIGCRFPGGVDSPDRLWDVVSEC TH_4621|M.thermoresistible__bu ------------VNIVGDTPVNAVAVIGMACRLPGGIDSPQRLWEALLRG :.:*::.:.** ** ..: :*. : Mflv_0405|M.gilvum_PYR-GCK VDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFFGL MAB_0939|M.abscessus_ATCC_1997 VDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFFGI MSMEG_0408|M.smegmatis_MC2_155 VDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFFGI Mvan_1003|M.vanbaalenii_PYR-1 ADLIREIPDDR-FDINEFYDPDPEAAGKIYSRYGGFLDGVDGFDPEFFGI Rv2048c|M.tuberculosis_H37Rv RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV Mb2074c|M.bovis_AF2122/97 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV MMAR_3025|M.marinum_M RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFDPAFFGV MUL_2266|M.ulcerans_Agy99 RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFEPAFFGV MAV_2450|M.avium_104 RDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGI MLBr_00135|M.leprae_Br4923 RDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGI TH_4621|M.thermoresistible__bu DDMVTEIPVDR-WDADDYFDPEPGVPGRTVSRWGAFLDDVAGFDPEFFGI * : :.* ** :* ::*:* . * :* *.*:* *:. ***: Mflv_0405|M.gilvum_PYR-GCK SPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGVAANEYA MAB_0939|M.abscessus_ATCC_1997 SPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGVGANEYA MSMEG_0408|M.smegmatis_MC2_155 SPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGVAANEYA Mvan_1003|M.vanbaalenii_PYR-1 SPREAVWIDPQQRLVLETAWEGLERAGYSAAALRGSRSGVYVGVGANEYS Rv2048c|M.tuberculosis_H37Rv GPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG Mb2074c|M.bovis_AF2122/97 GPSEALAMDPQQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG MMAR_3025|M.marinum_M GPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYG MUL_2266|M.ulcerans_Agy99 GPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYG MAV_2450|M.avium_104 APSEALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGYG MLBr_00135|M.leprae_Br4923 APSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTGIFAPSYG TH_4621|M.thermoresistible__bu SEREAISIDPQQRLLLETSWEAMEHAGLTPADVEGSSTGVFVGLSHDDYA . *.: ::**:*:.** **.:* ** . :.** :*::.*: *. Mflv_0405|M.gilvum_PYR-GCK HLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTACSSSLV MAB_0939|M.abscessus_ATCC_1997 HLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTACSSALV MSMEG_0408|M.smegmatis_MC2_155 HLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTACSSALV Mvan_1003|M.vanbaalenii_PYR-1 HLLSGGSLDGIEAQFITGNALNVIAGRVSFTLGLEGPAVAVDTACSSSLV Rv2048c|M.tuberculosis_H37Rv MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV Mb2074c|M.bovis_AF2122/97 MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV MMAR_3025|M.marinum_M MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV MUL_2266|M.ulcerans_Agy99 MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV MAV_2450|M.avium_104 MGAAPI----AEGFRLTGQSSSVASGRVSYVLGLEGPAVSVDTACSSSLV MLBr_00135|M.leprae_Br4923 SRDTGG----LQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLV TH_4621|M.thermoresistible__bu LLTSDAG-ALEEAYGFTGSAFSMASGRIAYRLGVHGPAVTVDTACSSSLL : : :** . :**::: **..****:*******:*: Mflv_0405|M.gilvum_PYR-GCK AVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFD MAB_0939|M.abscessus_ATCC_1997 AVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGRCKTFD MSMEG_0408|M.smegmatis_MC2_155 AVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFD Mvan_1003|M.vanbaalenii_PYR-1 AVHQACQGLQSGDCDLALAGGVNVLLSPATTIATSRARMLSPDGRCKTFD Rv2048c|M.tuberculosis_H37Rv ALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFA Mb2074c|M.bovis_AF2122/97 ALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFA MMAR_3025|M.marinum_M ALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFA MUL_2266|M.ulcerans_Agy99 ALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFA MAV_2450|M.avium_104 ALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRCKAYA MLBr_00135|M.leprae_Br4923 AIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFA TH_4621|M.thermoresistible__bu AVHMACRSLQVGESDLALAGGAMVMLEPRKYTSASGLGMLSPTGRCHAFD *:* * .*: *:.*:*****. : * * *: ***::: Mflv_0405|M.gilvum_PYR-GCK ASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGASSGLTV MAB_0939|M.abscessus_ATCC_1997 ASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGASSGLTV MSMEG_0408|M.smegmatis_MC2_155 ASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGASSGLTV Mvan_1003|M.vanbaalenii_PYR-1 AAADGYVRGEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDGASGGLTV Rv2048c|M.tuberculosis_H37Rv AAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTA Mb2074c|M.bovis_AF2122/97 AAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTA MMAR_3025|M.marinum_M GAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTA MUL_2266|M.ulcerans_Agy99 GAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTA MAV_2450|M.avium_104 GAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQDGASNGLTA MLBr_00135|M.leprae_Br4923 RAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLTA TH_4621|M.thermoresistible__bu VAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVRGTAANQDGRTENIST :*** .** :::::**.** * .. : *:: .::.**** : .::. Mflv_0405|M.gilvum_PYR-GCK PNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQAAAAAYA MAB_0939|M.abscessus_ATCC_1997 PNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAAAAYG MSMEG_0408|M.smegmatis_MC2_155 PNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQAAAAAYG Mvan_1003|M.vanbaalenii_PYR-1 PNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQAAGAVLG Rv2048c|M.tuberculosis_H37Rv PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG Mb2074c|M.bovis_AF2122/97 PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MMAR_3025|M.marinum_M PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MUL_2266|M.ulcerans_Agy99 PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MAV_2450|M.avium_104 PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MLBr_00135|M.leprae_Br4923 PNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQALLATYG TH_4621|M.thermoresistible__bu PSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTPVGDPIEYNSLTQVYG *. :* : :.*: **: . :. :*.***.*.:***** :: . . Mflv_0405|M.gilvum_PYR-GCK GARDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQSL MAB_0939|M.abscessus_ATCC_1997 GSRDAD----RPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQSL MSMEG_0408|M.smegmatis_MC2_155 AGRDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLPQSL Mvan_1003|M.vanbaalenii_PYR-1 AGRDPD----RPLLMGSVKTNVGHLESASGVAGLIKVVLSLQHEMLPRHL Rv2048c|M.tuberculosis_H37Rv QDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL Mb2074c|M.bovis_AF2122/97 QDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL MMAR_3025|M.marinum_M QDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATL MUL_2266|M.ulcerans_Agy99 QDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATL MAV_2450|M.avium_104 QDRGQP------LWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL MLBr_00135|M.leprae_Br4923 QGRPAD----QPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVMPATL TH_4621|M.thermoresistible__bu KTGPCA--------LTSVKTNFGHAESAAGALGMMKAILALQHGVVPQNL : *:*:*.** ::*:*. *::* : :::: :* * Mflv_0405|M.gilvum_PYR-GCK HFDTPSPHIPWDSLPVRVVDTAMPWQ---PNGRPRRAGVSSFGFTGTNAH MAB_0939|M.abscessus_ATCC_1997 HFDNPSPHIPWESLPVRVVDKAIPWQ---ANGRPRRAGVSSFGFTGTNAH MSMEG_0408|M.smegmatis_MC2_155 HFENPSPHIPWDALPVRVIDEPVPWQ---TNGRVRRAGVSSFGFTGTNAH Mvan_1003|M.vanbaalenii_PYR-1 HFKTPSPHIPWDRLAVRVVAEPTPWR---ADGRPRRAGVSSFGFSGTNAH Rv2048c|M.tuberculosis_H37Rv HVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISGTNAH Mb2074c|M.bovis_AF2122/97 HVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISGTNAH MMAR_3025|M.marinum_M HVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAH MUL_2266|M.ulcerans_Agy99 HVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAH MAV_2450|M.avium_104 HVDEPSPHVDWSAGAVSLLTEAQPWP----GERPRRAGVSSFGISGTNAH MLBr_00135|M.leprae_Br4923 HVDEPSPRVDWTTGAVSVLTEARDWS---VEGRPRRAGVSSFGISGTNAH TH_4621|M.thermoresistible__bu HFTRLPDEMAAIETNLFVPQATTLWP--VREGCPRRAAVSSYGMSGTNVH *. . .: : : . * ***.***:*::***.* Mflv_0405|M.gilvum_PYR-GCK VLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALV MAB_0939|M.abscessus_ATCC_1997 VLIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSPEALA MSMEG_0408|M.smegmatis_MC2_155 VLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSPEALV Mvan_1003|M.vanbaalenii_PYR-1 VVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAGVLPISARSPEALT Rv2048c|M.tuberculosis_H37Rv VIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSESALR Mb2074c|M.bovis_AF2122/97 VIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSESALR MMAR_3025|M.marinum_M VIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSGSALG MUL_2266|M.ulcerans_Agy99 VIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSGSALG MAV_2450|M.avium_104 VIIEAVP---------------AVEPAHADAPALPVLPWVVSAKSAAALR MLBr_00135|M.leprae_Br4923 VILEEAPTP------------VEASYSTADQQRLSVVPWVVSGRSTAALM TH_4621|M.thermoresistible__bu AVLEQAPEP------------VQRPEESADTDAAGPLVFALSSTSAEELR .::* * :*. * * Mflv_0405|M.gilvum_PYR-GCK ALAQRYETWLTAH-PEADLADVCRTAGTGRSHFEHRAALVVDSVESARIA MAB_0939|M.abscessus_ATCC_1997 AVAQRYESWLAAH-PDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREG MSMEG_0408|M.smegmatis_MC2_155 ELARRYDDWLSAT-PGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREG Mvan_1003|M.vanbaalenii_PYR-1 ALARRYESWLTAH-PDADIADVCYTAGAGRSHFEHRAALVVDSVDGARDL Rv2048c|M.tuberculosis_H37Rv GQAARLAAYVRGD-DGLDVADVGWSLA-GRSVFEHRAVVVGGDRDRLLAG Mb2074c|M.bovis_AF2122/97 GQAARLAAYVRGD-DGLDVADVGWSLA-GRSVFEHRAVVVGGDRDRLLAG MMAR_3025|M.marinum_M AQAARLAAHVRSH-DELDVADVGWSLA-GRSTFEHRAVVLGVDRDGLLAG MUL_2266|M.ulcerans_Agy99 AQAARLAAHVRSH-DELDVADVGWSLA-GRSTFEHRAVVLGADRDGLLAG MAV_2450|M.avium_104 AQAARLAEYVRAQ-GELDIADVGWTLA-GRATFEHRAVVVGGDRDRLLAG MLBr_00135|M.leprae_Br4923 AQASRLAFYVQAD-PEVDPVDVGCALA-ARSVFEHRAVVVGESREQLIAG TH_4621|M.thermoresistible__bu RTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVIADGVEALTAG * * : . *: : . *: *:.:: . : Mflv_0405|M.gilvum_PYR-GCK LTDLAQNRLR-PGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVF MAB_0939|M.abscessus_ATCC_1997 LLELAQNRLR-PGVVRGEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVF MSMEG_0408|M.smegmatis_MC2_155 LAALAEGRTP-AGVVRGEHVHRPTTAWLFTGQGSQYPGMARELFDTQPVF Mvan_1003|M.vanbaalenii_PYR-1 LAGLAEDRLG-PGAVRGVCGDPPKTAWLFTGQGSQYPGMARELFDTEPVF Rv2048c|M.tuberculosis_H37Rv LDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVF Mb2074c|M.bovis_AF2122/97 LDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVF MMAR_3025|M.marinum_M LDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVF MUL_2266|M.ulcerans_Agy99 LDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVF MAV_2450|M.avium_104 LDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVF MLBr_00135|M.leprae_Br4923 LAGLAVGESG-AGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVF TH_4621|M.thermoresistible__bu LREVADGDAP---YQPAVGMDDKAPVWVFSGQGSQWAGMGAELLATEQVF * :* . . .. :*.***:* **. * ** Mflv_0405|M.gilvum_PYR-GCK ADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFA MAB_0939|M.abscessus_ATCC_1997 AETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTSFAQPALFA MSMEG_0408|M.smegmatis_MC2_155 AQTVRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHTSFAQPALFA Mvan_1003|M.vanbaalenii_PYR-1 RDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----GQTLRHTSYAQPALFA Rv2048c|M.tuberculosis_H37Rv AEAFNTVVGELDRHLLRPLREVMWGH-------DENLLNSTEFAQPALFA Mb2074c|M.bovis_AF2122/97 AEAFNTVVGELDRHLLRPLREVMWGH-------DENLLNSTEFAQPALFA MMAR_3025|M.marinum_M AEAFNTVVGELDRHLLRPLREVIWGH-------DENLLNTTEFAQPALFA MUL_2266|M.ulcerans_Agy99 AEAFNTVVGELDRHLLRPLREVIWGH-------DENLLNTTEFAQPALFA MAV_2450|M.avium_104 AEAFDAVVAELDRHLLRPLRDVIWGD-------DENVLNSTEFAQPALFA MLBr_00135|M.leprae_Br4923 AEEFDAVTGELDRHMRLPLRDVVWGA-------DAGLLDSTEFAQPALFA TH_4621|M.thermoresistible__bu AAKIAEIEPLVARESGFSVTEAMTAS---------ETVTGIDRVQPTLFA . : .: :.: : . .**:*** Mflv_0405|M.gilvum_PYR-GCK VEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGR MAB_0939|M.abscessus_ATCC_1997 VEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGR MSMEG_0408|M.smegmatis_MC2_155 VEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGARLMAERGR Mvan_1003|M.vanbaalenii_PYR-1 IEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFGLEDGARLVADRGR Rv2048c|M.tuberculosis_H37Rv VEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGR Mb2074c|M.bovis_AF2122/97 VEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGR MMAR_3025|M.marinum_M VEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGR MUL_2266|M.ulcerans_Agy99 VEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGR MAV_2450|M.avium_104 VEVALFRLLESWGVRPDFVMGHSIGELSAAHVAGVLSLQNAAVLVAARGR MLBr_00135|M.leprae_Br4923 VEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAAMLVVARGR TH_4621|M.thermoresistible__bu IQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDGVKVICRRSR :::.* .: *. *:***:*: :** ***.:. :.. :: *.* Mflv_0405|M.gilvum_PYR-GCK LFGSLPEGGRMVAVFADAKRVEQVAADF--PRVSVGAYNGPN-TVLSGPG MAB_0939|M.abscessus_ATCC_1997 LFGGLPAGGRMVAVFSDAKHVEQIAGEF--PRVSVGAYNGPN-TVLSGPG MSMEG_0408|M.smegmatis_MC2_155 MFGSLPEGGRMVAVFADAEHVEQVAGEF--PRVSVGAYNGPN-TVLSGPG Mvan_1003|M.vanbaalenii_PYR-1 LFGGLPVGGRMVAVFTDAEVVEDFADEF--PQVSVAAYNGPN-TVLAGPA Rv2048c|M.tuberculosis_H37Rv LMQALPAGGAMVAVQAAEEEVRPLLS----AEVDIAAVNGPASLVISGAQ Mb2074c|M.bovis_AF2122/97 LMQALPAGGAMVAVQAAEEEVRPLLS----AEVDIAAVNGPASLVISGAQ MMAR_3025|M.marinum_M LMQALPDGGAMIAVQATEQEVLPLLG----AQVSIAAINGPASVVISGAQ MUL_2266|M.ulcerans_Agy99 LMQALPDGGAMIAVQATEQEVLPLLG----AQVSIATINGPASVVISGAQ MAV_2450|M.avium_104 FMQALPEGGAMIAVQATEAQVRPLLG----PDVGIAAVNGPAAVVISGDH MLBr_00135|M.leprae_Br4923 LMQSMPAGGTMWAVAASEDEVVSLLG----EGVGIAAINAPESVVISGPQ TH_4621|M.thermoresistible__bu LCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPESTVIGGAT : :. .* * *: * . * :.. .* *:.* Mflv_0405|M.gilvum_PYR-GCK EDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAP MAB_0939|M.abscessus_ATCC_1997 EDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQVQFAAP MSMEG_0408|M.smegmatis_MC2_155 EDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQFQFAAP Mvan_1003|M.vanbaalenii_PYR-1 SDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEFESCAARLAYAAP Rv2048c|M.tuberculosis_H37Rv NAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRP Mb2074c|M.bovis_AF2122/97 NAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRP MMAR_3025|M.marinum_M DAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAP MUL_2266|M.ulcerans_Agy99 DAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAP MAV_2450|M.avium_104 DAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLAIDKP MLBr_00135|M.leprae_Br4923 AAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKP TH_4621|M.thermoresistible__bu DTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEILADLQPMTP . :* : .. * ** ::*:::*: . . * Mflv_0405|M.gilvum_PYR-GCK TLPLVCNRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM MAB_0939|M.abscessus_ATCC_1997 TLPLVCNRTGAVLTAQTPIDGQYWRRHSRQPVQFAESVRTVAALGCSVLM MSMEG_0408|M.smegmatis_MC2_155 TLPLVCNRTGAVLTGQTPLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM Mvan_1003|M.vanbaalenii_PYR-1 TRPLVCNRTGAVVTGPGVIDAQYWRRHARQPVQFAESVRTLADLGCSVLM Rv2048c|M.tuberculosis_H37Rv TIGVISNVTG-QLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFL Mb2074c|M.bovis_AF2122/97 TIGVISNVTG-QLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFL MMAR_3025|M.marinum_M TIGIISNLTG-QLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFL MUL_2266|M.ulcerans_Agy99 TIGIISNLTG-QLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFL MAV_2450|M.avium_104 VIPIISNLTG-QPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFL MLBr_00135|M.leprae_Br4923 QIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFI TH_4621|M.thermoresistible__bu TVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQAALEDGFRVFG . *. . ** : *:*. : : * : Mflv_0405|M.gilvum_PYR-GCK EIGPQPVLTGAAVQVWPEHLAAPR--AIASLRKGVADRRQIADALAAAYI MAB_0939|M.abscessus_ATCC_1997 EIGPQPVLTGAAVQVWPEHLAPPR--AIVSLRKGVEDRRQIADALASAYV MSMEG_0408|M.smegmatis_MC2_155 EIGPQPVLTGAAVQVWPEHMAAPR--AVASLRKGVADRRQIADALASAYV Mvan_1003|M.vanbaalenii_PYR-1 EIGPQPFLIAAALRVWPESAATPR--AIPSLRKGPDARRQLAEAVAAAYI Rv2048c|M.tuberculosis_H37Rv EVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEPATLTNAVAQGFV Mb2074c|M.bovis_AF2122/97 EVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEPATLTNAVAQGFV MMAR_3025|M.marinum_M EVGPSSGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSAVAGVFV MUL_2266|M.ulcerans_Agy99 EVGPSIGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSALAGVFV MAV_2450|M.avium_104 EVGPSSGLTAAIEETLADAPVV----TVSALRKDRPEPVALVNAVAQGWV MLBr_00135|M.leprae_Br4923 ESGPSSGLMGAIEQSLAPAEAV----VVSMMGKDRPELASVLGAAGQLFA TH_4621|M.thermoresistible__bu ELSPHPLLTRAVEQTARGLDMPVA--ALPAMRREQEMPHGVRTMVGDLFA * .* * : . . : : : . : Mflv_0405|M.gilvum_PYR-GCK GGHKPDFAALHEQR-GVRLELPTYPFQRRRFWPK---SAGMAIDGRVGAS MAB_0939|M.abscessus_ATCC_1997 SGHRPNFAALQRHP-RRTVELPTYPFQRRRFWPK---SSGTAIEG--GGG MSMEG_0408|M.smegmatis_MC2_155 GGHRPDFAAVHRQP-RRPVELPTYPFQRRRFWPK---ASSIAVDG---GT Mvan_1003|M.vanbaalenii_PYR-1 AGHRLDFTGHDGGP-HRRLPLPTYPFQHRSYWPK---TAGIRSDG----S Rv2048c|M.tuberculosis_H37Rv TGMDLDWRAVVGEA--QFVELPTYAFQRRRFWLS-GDGVAADAAGLGLAA Mb2074c|M.bovis_AF2122/97 TGMDLDWRAVVGEA--QFVELPTYAFQRRRFWLS-GDGVAADAASLGLAA MMAR_3025|M.marinum_M AGTAVDWRAVVGQS--NFVELPTYAFERRRFWLS-GDAVAADAAGLGLQA MUL_2266|M.ulcerans_Agy99 AGTAVDWRAVVGQS--HFVELPTYAFERRRFWLS-GDAVPADAAGLGLQA MAV_2450|M.avium_104 CGMDVDWRGALGTG--HLVDLPTYAFDRRRFWLS-GDGAASDAAGLGLAA MLBr_00135|M.leprae_Br4923 TGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGTASVSGLGLGS TH_4621|M.thermoresistible__bu AGAAVDFAALYPSG--RLVDAPLPTWTRRKLVLS--RENGEQQTRGGCTI * :: . : * .: :* . Mflv_0405|M.gilvum_PYR-GCK AGSGILGSGKD-LASGD-SVYTSRLSVKTQPWLSDHVIYGTVVVPGATYA MAB_0939|M.abscessus_ATCC_1997 LPSGILGRGED-LASGD-SVYISRLSVRSQPWLSDHVIYGTVVVPGATYA MSMEG_0408|M.smegmatis_MC2_155 AASGILGSGKD-LASGD-TIYTSRLSVKSQPWLADHVIYGTVVVPGATYA Mvan_1003|M.vanbaalenii_PYR-1 SGSGLLGSAQD-LASGD-IVHTSRLSVKTQPWLSDHVIYGTVVVPGATYA Rv2048c|M.tuberculosis_H37Rv SEHALLGAVIDLPASGG-VVLTGRLSPSVQGWLADHSVAGVTIFPGAGFV Mb2074c|M.bovis_AF2122/97 SEHALLGAVIDLPASGG-VVLTGRLSPSVQGWLADHSVAGVTIFPGAGFV MMAR_3025|M.marinum_M GEHALLGAVVELPASGG-VVLTGRLSLAAQGWLADHAVGGVVIFPGAGFV MUL_2266|M.ulcerans_Agy99 GEHALLGAVVELPASGG-VVLTGRLSLAAQGWLADHAVGGVVIFPGAGFV MAV_2450|M.avium_104 GDHALLGAVVELPASGG-VLLTGRLSPASQGWLADHAVGGVVLFPGAGFV MLBr_00135|M.leprae_Br4923 TEHALLGAVVERPDSGG-VVLTGRLSLANQPWLADHVIGGVVLFPGAGFV TH_4621|M.thermoresistible__bu TVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAALPGAAYC :** . : . *. * **:** : .. .*** : Mflv_0405|M.gilvum_PYR-GCK AMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTVHPSVDGE-SKFQ MAB_0939|M.abscessus_ATCC_1997 AMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQLTLHPLEDGSGSKFQ MSMEG_0408|M.smegmatis_MC2_155 AMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTLHPADGGSVLSFQ Mvan_1003|M.vanbaalenii_PYR-1 AMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQLMLHRTDDADGWTFE Rv2048c|M.tuberculosis_H37Rv ELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGPDESGVRGVS Mb2074c|M.bovis_AF2122/97 ELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVS MMAR_3025|M.marinum_M ELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVS MUL_2266|M.ulcerans_Agy99 ELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVS MAV_2450|M.avium_104 ELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVVVDGPDDSGARAVS MLBr_00135|M.leprae_Br4923 ELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAVS TH_4621|M.thermoresistible__bu EMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVASAVEPGTLEFA :.: * : : : . Mflv_0405|M.gilvum_PYR-GCK VHSRPYGERGAE-WALNAEGVVASGVGD---SPAAAGDLEDPVDEAIERL MAB_0939|M.abscessus_ATCC_1997 VHSRPYGERDVD-WSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERM MSMEG_0408|M.smegmatis_MC2_155 IHSRPYGERGAD-WSLNAEGTVDTAGSD---PDAAADEQSDPVDEVIERL Mvan_1003|M.vanbaalenii_PYR-1 VHSRPYGDRDAD-WSRNASGTVAAGVGD-----AAPDAAADPVDNAIERL Rv2048c|M.tuberculosis_H37Rv VYSR--GDVGTG-WVLHAEGALRAGSAE-----PTADLAMWPPAGAVP-- Mb2074c|M.bovis_AF2122/97 VYSR--GDVGTG-WVLHAEGALRAGSAE-----PTADLAMWPPAGAVP-- MMAR_3025|M.marinum_M VYSR--GDAGSD-WVLHAEGSLGSGSPE-----PATDLSTWPPVGAVE-- MUL_2266|M.ulcerans_Agy99 VYSR--GDAGSD-WVLHAEGSLGSGSPE-----PATDLSTWPPVGAVE-- MAV_2450|M.avium_104 VFSR--ADAGAG-WLLHAEGVLRAGSAQ-----PATDLSAWPPVGAVP-- MLBr_00135|M.leprae_Br4923 VYSR--GDQSHGGWLLNAEGLLEVDAAE-----ATVDLSLWPPEGAES-- TH_4621|M.thermoresistible__bu VETAKDGEHERR--ATAVLGAADDTEPP-----QAHDIDALLAEHPTR-- : : .: . * Mflv_0405|M.gilvum_PYR-GCK NRMRPQELFETFADLELAWGPTWSGSLKSLWLG--EGEAIGDILVGAELA MAB_0939|M.abscessus_ATCC_1997 ERMRPMELFEIFADLELAWGPTWSGSLKSLWLG--EGEAIGDVLVGEELA MSMEG_0408|M.smegmatis_MC2_155 ERMRPQDLFETFADLELAWGPTWSGSLKSLWLG--DGEAVGDILVGAELA Mvan_1003|M.vanbaalenii_PYR-1 TRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVG--TGEAVGDIAVGAELG Rv2048c|M.tuberculosis_H37Rv --VEVADGYQQLAERGYGYGPAFRG-LTAMWRR--GDEVFAEVALPADAG Mb2074c|M.bovis_AF2122/97 --VEVADGYQQLAERGYGYGPAFRG-LTAMWRR--GDEVFAEVALPADAG MMAR_3025|M.marinum_M --VENADGYQQLAERGYGYGPAFRG-LNAMWRR--GDEVFAEVALPADAG MUL_2266|M.ulcerans_Agy99 --VENADGYQQLAERGYGYGPAFRG-LNAMWRR--GDEVFAEVALPADAG MAV_2450|M.avium_104 --VDLGDGYEQLAERGYRYGPAFRG-LTSMWRR--GDEIFAEVNLPTDAG MLBr_00135|M.leprae_Br4923 --VDISDAYPQLAERGYAYGPAFQG-LVAIWRR--GSELFAEVVAPT--G TH_4621|M.thermoresistible__bu --IEGDELRQWFDQRGVQFGPAFTGLTAARIPEGTVTSVLAEVGLPGQIR : : : :**:: . : . ..:: Mflv_0405|M.gilvum_PYR-GCK EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQE MAB_0939|M.abscessus_ATCC_1997 EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKE MSMEG_0408|M.smegmatis_MC2_155 EQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAE Mvan_1003|M.vanbaalenii_PYR-1 EHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADPELFLPLRYGRVEVRE Rv2048c|M.tuberculosis_H37Rv VSVTGFGVHPVLLDAALHAVVLSAESAERG---QGSVLVPFSWQGVSLHA Mb2074c|M.bovis_AF2122/97 VSVTGFGVHPVLLDAALHAVVLSAESAERG---QGSVLVPFSWQGVSLHA MMAR_3025|M.marinum_M VSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHA MUL_2266|M.ulcerans_Agy99 VSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHA MAV_2450|M.avium_104 VSTTGFGVHPVMLDAALHAVMLASDGDDLP---AGSMLVPFSWQRVSLHA MLBr_00135|M.leprae_Br4923 VVVDGMGMHPALLDAVLHALGLAIENTQAT----TEMRLPFCWRGVSLHA TH_4621|M.thermoresistible__bu SQQAPYGIHPALLDACFQSVAAHPDVQGAG----SGLLLPLGVRRLQAFG :**.::* : :*: : Mflv_0405|M.gilvum_PYR-GCK KMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTVKRAPRE MAB_0939|M.abscessus_ATCC_1997 KMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPRE MSMEG_0408|M.smegmatis_MC2_155 KMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRAPRE Mvan_1003|M.vanbaalenii_PYR-1 RMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGGIREFTVKRAPRE Rv2048c|M.tuberculosis_H37Rv AGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASMLARPVTDQ Mb2074c|M.bovis_AF2122/97 AGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASMLARPVTDQ MMAR_3025|M.marinum_M AGASAVRARIAPAG------PSAVSIELSDGLGLPVLSVASMLARPVTDQ MUL_2266|M.ulcerans_Agy99 AGASAVRARIAPAG------PSAVSIELSDGLGLPVLSVASMLARPVTDQ MAV_2450|M.avium_104 AGAAAVRARIVPVS------PSAVSIELADGLGLPVLSVASMVARPVTDQ MLBr_00135|M.leprae_Br4923 GGAGRVRARFTSAG------ADAIAVDIADSAGLPVLTVRSLVTRAMTAE TH_4621|M.thermoresistible__bu PTRGARYCYARVTDAD--GSKAEADLDVLDEHGNVLLRVQGLLMGGAAAD . :: * * : : : . : Mflv_0405|M.gilvum_PYR-GCK ALLRGLGGDA---TRLLYTLGWHEVPVP----ESGDGAAPQGTWLIGGFD MAB_0939|M.abscessus_ATCC_1997 ALLRGLGGDA---TRLLYTLGWHEVAVPPVAGEGEESAASIGTWLIAGFD MSMEG_0408|M.smegmatis_MC2_155 ALLRGLGGDA---TRLLYTLGWHEVPPP------PSADDAVGTWLIAGFD Mvan_1003|M.vanbaalenii_PYR-1 ALLRGLGADA---TRLIYRVGWRETSPP---VRDDGALGPSSTWLVAGLD Rv2048c|M.tuberculosis_H37Rv QLRAAVSSSG---PDRLFEVTWSPQPSA-------AVEP----LPVCAWG Mb2074c|M.bovis_AF2122/97 QLRAAVSSSG---PDRLFEVTWSPQPSA-------AVEP----LPVCAWG MMAR_3025|M.marinum_M QLRAAVSGAG---PDRLFGVDWTAQPSA-------ELQP----VPVRIWG MUL_2266|M.ulcerans_Agy99 QLRAAVSGAG---PDRLFGVDWTAQPSA-------ELQP----VPVRIWG MAV_2450|M.avium_104 QLLAAVSNSG---PDRLFELIWSAQPST-------AVQP----VSLLNWG MLBr_00135|M.leprae_Br4923 QLRTAVTAAGGALEQGPMDLVWSPIPLS-------SDGHGGGLPSVVSWA TH_4621|M.thermoresistible__bu GDDRDRVLGER-----LLTIEWQRRDLP-------EADSAAGKWLLVSTS : * . : Mflv_0405|M.gilvum_PYR-GCK ELAVSVPGCIPADR----------------TNPESLRQLLTDAHGRGLPF MAB_0939|M.abscessus_ATCC_1997 ELAAKVPGCIPLNRE---------------TDPELLGEVLVAAKERGVPF MSMEG_0408|M.smegmatis_MC2_155 ELAAKVPGCVPIDRN---------------TDLQVLGEVLSQAHARGAGF Mvan_1003|M.vanbaalenii_PYR-1 ALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFALADERRAPV Rv2048c|M.tuberculosis_H37Rv TTEDS--------------------------------------------- Mb2074c|M.bovis_AF2122/97 TTEDS--------------------------------------------- MMAR_3025|M.marinum_M AVESEGDDDPG--------------------------------------- MUL_2266|M.ulcerans_Agy99 TVESEGDDDPG--------------------------------------- MAV_2450|M.avium_104 ATELDATDTDSDSGR----------------------------------- MLBr_00135|M.leprae_Br4923 DYCAGRGNDTG--------------------------------------- TH_4621|M.thermoresistible__bu ATADVSATRLSDALKQAG----------AESTSMCWPQQADHADNVDRFR Mflv_0405|M.gilvum_PYR-GCK SGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQ---GGEVKLP MAB_0939|M.abscessus_ATCC_1997 SGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLP MSMEG_0408|M.smegmatis_MC2_155 SGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQ---GPSVKLP Mvan_1003|M.vanbaalenii_PYR-1 AGVVLGVTGRARPEE-PSADFAARLEAQIRDVLGAVHSLS---ALGAKPA Rv2048c|M.tuberculosis_H37Rv AAVVFESVPLAG-------DVVAGVYAATSSVLDVLQSWLT-----RDGA Mb2074c|M.bovis_AF2122/97 AAVVFESVPLAG-------DVVAGVYAATSSVLDVLQSWLT-----RDGA MMAR_3025|M.marinum_M ASVVFESVPQAG-------EVVAGVYAATAAVLEVLRSWLS-----RDGA MUL_2266|M.ulcerans_Agy99 ASVVFESVPQAG-------EVVAGVYAATAAVLEVLRSWLS-----RDGA MAV_2450|M.avium_104 FAVLFESAPVAG-------DVVTEVYAATRAVLPVLQSWLA-----RDGA MLBr_00135|M.leprae_Br4923 -VVVWEFGSASAGAQ-APVDSVAAVYSATHAALQVLQFWFG-----QDRA TH_4621|M.thermoresistible__bu AGIADGVTGVVVLTGPKNGNPDDAAARRGSDYVRHLVRITRELAEIDGDA : : : . Mflv_0405|M.gilvum_PYR-GCK GGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGS MAB_0939|M.abscessus_ATCC_1997 GGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGS MSMEG_0408|M.smegmatis_MC2_155 GGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGS Mvan_1003|M.vanbaalenii_PYR-1 AGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLIAEEPGLRCLLVDLDGS Rv2048c|M.tuberculosis_H37Rv GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDSD-A Mb2074c|M.bovis_AF2122/97 GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDSD-A MMAR_3025|M.marinum_M GQLVITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPG-RIVLVDTD-A MUL_2266|M.ulcerans_Agy99 GQLIITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPG-RIVLVDTD-A MAV_2450|M.avium_104 GTLVVSTRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDTD-A MLBr_00135|M.leprae_Br4923 GTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSG-KIVLIDTD-S TH_4621|M.thermoresistible__bu PRLFVVTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADD * : *. . : :.: *: * *.. : :* Mflv_0405|M.gilvum_PYR-GCK PQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGH----LTVPR MAB_0939|M.abscessus_ATCC_1997 PEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGH----LTVPR MSMEG_0408|M.smegmatis_MC2_155 SEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGH----LTLPR Mvan_1003|M.vanbaalenii_PYR-1 EDAGPALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQ----LAIPR Rv2048c|M.tuberculosis_H37Rv PLDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGG----LLVPP Mb2074c|M.bovis_AF2122/97 PLDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGG----LLVPP MMAR_3025|M.marinum_M QLDEHAVAAVLAAG---EPQVLWRNGEVYTARVHGSRAVAG----LLVPP MUL_2266|M.ulcerans_Agy99 QLDEHAVAAVLAAG---EPQVLWRNGEVYTARVHGSRAVAG----LLVPP MAV_2450|M.avium_104 PLDADAVAAVLAVG---EPQTLLRNGTVYTARVLGSRAVGA----LLVPP MLBr_00135|M.leprae_Br4923 AVD---VAVLADLG---ESQLLVRCNTVHAARLS--PAPQL----LALPV TH_4621|M.thermoresistible__bu ADLDRVAVQLLGGG--AEDETAWRDGQWYTARLSLSPLRPEERKQAVVDC . : * : * . ..*: : Mflv_0405|M.gilvum_PYR-GCK GGD-YVLAPTERGAIDNLRLTDS-EVPPPAE-GYVQVRVEAAGLNFRDVL MAB_0939|M.abscessus_ATCC_1997 GSD-YVLAPTERGAIDNLRITEK-EVPAPDE-GYVQVRVEAAGLNFRDVL MSMEG_0408|M.smegmatis_MC2_155 GGD-FVLAPTERGAIDNLRLTET-DVPEPDE-GYVQVRVEAAGLNFRDVL Mvan_1003|M.vanbaalenii_PYR-1 GTD-YVLAPTERGVLDNLRVSET-EVTAPPE-GHVQVRVEAAGLNFRDVL Rv2048c|M.tuberculosis_H37Rv SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVM Mb2074c|M.bovis_AF2122/97 SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVM MMAR_3025|M.marinum_M GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM MUL_2266|M.ulcerans_Agy99 GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM MAV_2450|M.avium_104 EDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSALAANFRDVM MLBr_00135|M.leprae_Br4923 GESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVV TH_4621|M.thermoresistible__bu ERDGMRLEIRTPGDLETMELAAFDRVPPGPG--QIEVAVTASSINFADVL * * :: : : . :.* * . ** **: Mflv_0405|M.gilvum_PYR-GCK NVLGLYPGDPG---PIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFA- MAB_0939|M.abscessus_ATCC_1997 NVLGLYPGDPG---PIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFG- MSMEG_0408|M.smegmatis_MC2_155 NVLGLYPGDPG---PIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFA- Mvan_1003|M.vanbaalenii_PYR-1 NALGLYPGDPG---PIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFA- Rv2048c|M.tuberculosis_H37Rv IALGLYPDPDA---VMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG- Mb2074c|M.bovis_AF2122/97 IALGLYPDPDA---VMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG- MMAR_3025|M.marinum_M IALGLYPDPDA---AMGVEGAGVVVETASTDGRFAVGDRVVGLFPEGTG- MUL_2266|M.ulcerans_Agy99 IALGLYPDPDA---AMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGTG- MAV_2450|M.avium_104 IALGLYPDPDA---VMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTG- MLBr_00135|M.leprae_Br4923 AALGMYPGQAP---PLGAEGAGVVIEIGPEVTGVAVGDAVMG-FLGGAG- TH_4621|M.thermoresistible__bu IAFGRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWS .:* ** :* : .* * . :*: * * . Mflv_0405|M.gilvum_PYR-GCK SRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRLSF-DWAQVKSGDKVLI MAB_0939|M.abscessus_ATCC_1997 SRFNVPAQFLAPIPDGISGVEAATIPAAALTVRLSF-DWAQLKPGDKVLI MSMEG_0408|M.smegmatis_MC2_155 SRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAF-DWAQLKPGDKVLI Mvan_1003|M.vanbaalenii_PYR-1 SRVNVPVQFLAPVPEGISAVAAATTPAAVLTAGLAF-DWAALRAGDRVLI Rv2048c|M.tuberculosis_H37Rv TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLI Mb2074c|M.bovis_AF2122/97 TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLADVQPGQRVLI MMAR_3025|M.marinum_M TIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV MUL_2266|M.ulcerans_Agy99 TIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV MAV_2450|M.avium_104 TVATTDQRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLV MLBr_00135|M.leprae_Br4923 PLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLI TH_4621|M.thermoresistible__bu TFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLI . : . :* * **: ... *. .: * * .*: :*: Mflv_0405|M.gilvum_PYR-GCK HAASGGVGLAAVQMAQQCGAEVYATAST-FKRATLRKLG--VKHVYDSRT MAB_0939|M.abscessus_ATCC_1997 HAASGGVGLAAIQMAQQFGAEVFATAST-FKRATLRKLG--VKYVYDSRT MSMEG_0408|M.smegmatis_MC2_155 HAASGGVGLAAIQMAQQSGAEVFATAST-FKRSTLRRLG--VKYVYDSRT Mvan_1003|M.vanbaalenii_PYR-1 HAASGGVGLAAVQLARQRGATVFATASG-YKRPMLRAMG--VDHVYDSRT Rv2048c|M.tuberculosis_H37Rv HAGTGGVGMAAVQLARHLGLEVFATASK-GKWDTLRAMGFDDDHISDSRS Mb2074c|M.bovis_AF2122/97 HAGTGGVGMAAVQLARHLGLEVFATASK-GKWDTLRAMGFDDDHISDSRS MMAR_3025|M.marinum_M HAATGGVGMAAVQLARHWGLEVFATASK-GKWDTLRAMGFDEDHIGDSRS MUL_2266|M.ulcerans_Agy99 HAATGGVGMAAVQLARHWGLEVFATASK-GKWDTLRAMGFDEDHIGDSRS MAV_2450|M.avium_104 HAAAGGVGMAAVQLARHLGLEVFATASR-GKWDTLRDMGFDDDHLGDSRG MLBr_00135|M.leprae_Br4923 HAGTGGVGMAAVQFARHWGVEIFVTASR-GKWDTLRDMGFDDDHIGDSRT TH_4621|M.thermoresistible__bu HSATGGVGLAAIAIARSVGAQIYATAGSPARRDLLRDMG--IEHVYDSRS *:.:****:**: :*: * ::.**. : ** :* .:: *** Mflv_0405|M.gilvum_PYR-GCK TDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDI MAB_0939|M.abscessus_ATCC_1997 TDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDI MSMEG_0408|M.smegmatis_MC2_155 TDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDI Mvan_1003|M.vanbaalenii_PYR-1 TDFADQILADTDGAGVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDI Rv2048c|M.tuberculosis_H37Rv LEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI Mb2074c|M.bovis_AF2122/97 LEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI MMAR_3025|M.marinum_M LEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI MUL_2266|M.ulcerans_Agy99 LEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI MAV_2450|M.avium_104 LDFEDKFRAVTGGAGMDIVLDSLSGD-SVDASLRLVAPGGIFLEMGKTDI MLBr_00135|M.leprae_Br4923 LEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDI TH_4621|M.thermoresistible__bu TAFADEIRRDTDGYGVDVVLNSLPGA-AQRAGLELLSFGGRFIEIGKRDI * ::: *.* *.*:**:**.. * :. * * *:.* ** Mflv_0405|M.gilvum_PYR-GCK WTVEQMAAA--RPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWT MAB_0939|M.abscessus_ATCC_1997 WTTEQMAQS--RPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWT MSMEG_0408|M.smegmatis_MC2_155 WSHEQMAEA--RPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWT Mvan_1003|M.vanbaalenii_PYR-1 WSPEQMAAA--RPDIDYEVLALDAVMQQDPDRIQLLLADLADSLARGETA Rv2048c|M.tuberculosis_H37Rv RDPGVIAQQ--YPGVRYRAFDLFEPG---PDRIAQILAELATLFGDGVLR Mb2074c|M.bovis_AF2122/97 RDPGVIAQQ--YPGVRYRAFDLFEAG---PDRIAQILAELATLFGDGVLR MMAR_3025|M.marinum_M REAAVVAQQ--HTGVRYRAFDLFEAG---PDHIAQILAELAALFSEDALR MUL_2266|M.ulcerans_Agy99 REAAVVAQQ--HTGVRYRAFDLFEAG---PDHIAQILAELAALFSEDVLR MAV_2450|M.avium_104 RDPEVVAAE--HPGVRYRAFDLFEAG---PDRIARLLDELAAMFGEDVLR MLBr_00135|M.leprae_Br4923 RDAQEIAAN--YPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQVLH TH_4621|M.thermoresistible__bu YGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYRLTADGVLP :. .: :. . * * :: :* : Mflv_0405|M.gilvum_PYR-GCK PLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNP-LQPQPDRSYLITGG MAB_0939|M.abscessus_ATCC_1997 PLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNP-LAPRPDRTYLITGG MSMEG_0408|M.smegmatis_MC2_155 PLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKP-LQPQQDRSYLITGG Mvan_1003|M.vanbaalenii_PYR-1 PLPFEAYPLAEATTAFRRMQQARHTGKIILQMPKP-LQPHGDRSYLITGG Rv2048c|M.tuberculosis_H37Rv PLPVTTFDVRCAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGG Mb2074c|M.bovis_AF2122/97 PLPVTTFDVRRAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGG MMAR_3025|M.marinum_M PLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGG MUL_2266|M.ulcerans_Agy99 PLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGG MAV_2450|M.avium_104 PLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITGA MLBr_00135|M.leprae_Br4923 RLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGA TH_4621|M.thermoresistible__bu MPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVP----------------- : : * :*:* :. *.* **:: :* Mflv_0405|M.gilvum_PYR-GCK LGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHV MAB_0939|M.abscessus_ATCC_1997 LGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHV MSMEG_0408|M.smegmatis_MC2_155 LGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHT Mvan_1003|M.vanbaalenii_PYR-1 LGALG-LHAAAYLAQLGAGDIVLTGRRMPDAATERAISEIAERYHCRIHT Rv2048c|M.tuberculosis_H37Rv TGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQV Mb2074c|M.bovis_AF2122/97 TGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQV MMAR_3025|M.marinum_M TGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQV MUL_2266|M.ulcerans_Agy99 TGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQV MAV_2450|M.avium_104 TGMAGSAVARHVVTRHGARNLVLVSRRGLDAPDAAELVAELTAAGAHAEV MLBr_00135|M.leprae_Br4923 SGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGAVELAAELVGAGAKIQV TH_4621|M.thermoresistible__bu --------------HTGRADVVVPPEQASPFRSDGAYIVTGGMGGLGLYL * .:*: .: Mflv_0405|M.gilvum_PYR-GCK FTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRT MAB_0939|M.abscessus_ATCC_1997 FTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRT MSMEG_0408|M.smegmatis_MC2_155 YAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRT Mvan_1003|M.vanbaalenii_PYR-1 FAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQQSPERFRT Rv2048c|M.tuberculosis_H37Rv VACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDV Mb2074c|M.bovis_AF2122/97 VACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDV MMAR_3025|M.marinum_M VACDAADRAALAKLIADIPVQHP-LSAVIHTAGALDDAVVTSLTPERMET MUL_2266|M.ulcerans_Agy99 VACDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVVTSLTPERIET MAV_2450|M.avium_104 VACDAADREALAKVIADIPMQHP-LTGVIHAAGVLDDAVVTSLTPQRIDT MLBr_00135|M.leprae_Br4923 VACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDT TH_4621|M.thermoresistible__bu AGEMAAAGAGCIVLNGRSAPSGEALRTIEQLRAAGTEVIVECGXXXRGQP .. : . : : : .. : : * Mflv_0405|M.gilvum_PYR-GCK ALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLD MAB_0939|M.abscessus_ATCC_1997 TLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLD MSMEG_0408|M.smegmatis_MC2_155 TLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLD Mvan_1003|M.vanbaalenii_PYR-1 TLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANYATANAVLD Rv2048c|M.tuberculosis_H37Rv VLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD Mb2074c|M.bovis_AF2122/97 VLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD MMAR_3025|M.marinum_M VLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLD MUL_2266|M.ulcerans_Agy99 VLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLD MAV_2450|M.avium_104 VLRAKVDAAWNLHELTRDLDVGAFVMFSSIAGLAGASGQGNYAAGNSFLD MLBr_00135|M.leprae_Br4923 VLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLD TH_4621|M.thermoresistible__bu VEVAVPTELRHADEHPD----------RRGAQLCDEFARGEQGAQRNQHR . . .. . : . .:.: .: . Mflv_0405|M.gilvum_PYR-GCK GLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANIS---AQGLIPLEPS MAB_0939|M.abscessus_ATCC_1997 GLIAQRRAQGLPATGINFGPWGQGGMASSEAATANIS---AQGLIPLDPS MSMEG_0408|M.smegmatis_MC2_155 GLVAKRRAQGLVATGINFGPWGQGGMASSEAATANIT---AQGLIPLDPS Mvan_1003|M.vanbaalenii_PYR-1 GLVAHRKARGLPATGVNWGPWAQGGMATSDAARANLG---AQGLIPLEPT Rv2048c|M.tuberculosis_H37Rv ALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSA Mb2074c|M.bovis_AF2122/97 ALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIVAMSSA MMAR_3025|M.marinum_M GLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSD MUL_2266|M.ulcerans_Agy99 GLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSD MAV_2450|M.avium_104 GLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARFGRDGIVAMSSQ MLBr_00135|M.leprae_Br4923 GLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPA TH_4621|M.thermoresistible__bu TDAGEGQRDAHPPGAVGHDQPDPGALSDTGLDERGGQFPGVGVQIPVADP : . .: . . . .: Mflv_0405|M.gilvum_PYR-GCK AALTAMAEVVANGTAQATVLKANWQR-AAKVLGSSRPPILDLVLPSAVGE MAB_0939|M.abscessus_ATCC_1997 AALAALAEVVANGTGQATILKANWQR-AAKVLGSSRPPILDLVLPSAVGE MSMEG_0408|M.smegmatis_MC2_155 AALHALAEVIANGSGQATVLKANWQR-AAKVLGSARPPILDLVLPSAAGE Mvan_1003|M.vanbaalenii_PYR-1 AALNALGEIVAHGIASAVVLKANWQR-AAKLLGATRPPILDHVLPSAVAA Rv2048c|M.tuberculosis_H37Rv DALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRR Mb2074c|M.bovis_AF2122/97 DALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRR MMAR_3025|M.marinum_M EALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRR MUL_2266|M.ulcerans_Agy99 EALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRR MAV_2450|M.avium_104 EALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVDLINAPTRR MLBr_00135|M.leprae_Br4923 QALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRR TH_4621|M.thermoresistible__bu GVGIDHRGAVRVDSGVPAQQGVDGEVVRHRTLSSVRSGRSSRWTAPGSRC . : . : : .. . Mflv_0405|M.gilvum_PYR-GCK ITGDS--------ELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPA MAB_0939|M.abscessus_ATCC_1997 VTGDS--------ELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPPA MSMEG_0408|M.smegmatis_MC2_155 ATGDS--------ELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPPA Mvan_1003|M.vanbaalenii_PYR-1 GPGDS--------ALLKQLQDVPEAQRGSFVTEHLQRELQQILGLAQPPA Rv2048c|M.tuberculosis_H37Rv QVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEA Mb2074c|M.bovis_AF2122/97 QVDDSLAAAKSKSALAHRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEA MMAR_3025|M.marinum_M QVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDA MUL_2266|M.ulcerans_Agy99 QVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDA MAV_2450|M.avium_104 QVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEA MLBr_00135|M.leprae_Br4923 QIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPED TH_4621|M.thermoresistible__bu G-------------SGRRYGGESCRRTTGPAAGAAARRGRTRRRRRPRRP :: . . . Mflv_0405|M.gilvum_PYR-GCK ATS--RFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAE MAB_0939|M.abscessus_ATCC_1997 ATS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAE MSMEG_0408|M.smegmatis_MC2_155 ASS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAE Mvan_1003|M.vanbaalenii_PYR-1 ATG--RFLELGMDSLMAVELRNRLVGQFGSGFTITATAVFDYPTIGALAE Rv2048c|M.tuberculosis_H37Rv IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG Mb2074c|M.bovis_AF2122/97 IDPDRAFQDLGFDSLTAVEMRNRLKSATG--LSLSPTLIFDYPNSAALAG MMAR_3025|M.marinum_M IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG MUL_2266|M.ulcerans_Agy99 IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG MAV_2450|M.avium_104 IHPDRAFQELGFDSLTAVEMRNRLKAATG--LALSPTLIFDYPNSAALAG MLBr_00135|M.leprae_Br4923 IDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLPPTVIFDHPTPTAVAE TH_4621|M.thermoresistible__bu PPPPDRVRHRAGPAHGPVRR------------------------------ . . . : .:. Mflv_0405|M.gilvum_PYR-GCK YLVAQLPDAETP-------------------------------------Q MAB_0939|M.abscessus_ATCC_1997 YLVGQLPDADAE-------------------------------------S MSMEG_0408|M.smegmatis_MC2_155 YLVGQLPDAEAP-------------------------------------E Mvan_1003|M.vanbaalenii_PYR-1 YLAAQTPESTEE-------------------------------------G Rv2048c|M.tuberculosis_H37Rv YMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALA Mb2074c|M.bovis_AF2122/97 YMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALA MMAR_3025|M.marinum_M YMHRELVGASPQSDITAEAPGEAELQRVVASIPVKRLRQAGVLELLLALA MUL_2266|M.ulcerans_Agy99 YMHRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQAGVLELLLALA MAV_2450|M.avium_104 YMYRELVGTSEQ-PTAAAAPGEAEIQRVVGSIPVKRLRQAGVLELLLALA MLBr_00135|M.leprae_Br4923 YVAQQMLKSRPA-------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAP-------QSESEPGPDVTE----------------- MAB_0939|M.abscessus_ATCC_1997 AEAPPAVESAEAESGAGPAAASDAVSELKE--------- MSMEG_0408|M.smegmatis_MC2_155 TA------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 TEMKTADPDGQPATVGHADVVLQTS-------------- Rv2048c|M.tuberculosis_H37Rv NETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- Mb2074c|M.bovis_AF2122/97 NETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- MMAR_3025|M.marinum_M NETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE- MUL_2266|M.ulcerans_Agy99 NETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE- MAV_2450|M.avium_104 NESTGTAQSATPAVTTEKDIADMDLDDLVNAALLDDDDE MLBr_00135|M.leprae_Br4923 -ESGDETSQAVEPKVEEVSVHA----------------- TH_4621|M.thermoresistible__bu ---------------------------------------