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VMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGVDSPEALWQMVAEGRDVISE FPTDRGWDLAALYDPDPDARHKCYVNTGGFVDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERA GIDPSGLRGSATGVFAGLIVQGYGMLAEEIEGYRLTGMTSSVASGRVSYVLGLEGPAVSVDTACSSSLVA LHMAVQSLRSGECDLALAGGATVNATPTVFVEFSRHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLS DARRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIE AQALLATYGQDRGQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDEPSPHVDWSAGAVS LLTEAQPWPGERPRRAGVSSFGISGTNAHVIIEAVPAVEPAHADAPALPVLPWVVSAKSAAALRAQAARL AEYVRAQGELDIADVGWTLAGRATFEHRAVVVGGDRDRLLAGLDELAADDPAASIIRGVATPAGKTVFVF PGQGSQWLGMATELLDTAPVFAQHIQACEEAFAEFVDWSLIDALRGAPGAAGMDRVDVVQPALFAVMVSL AELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLLRSLAGPGGMLSIACSTERARELL APYGNRVSIAAVNGRSAVVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIE PRSSRIAFFSTVTGNRLDTAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRTFIESSPHPALVAGIEDTVN DSLPGDTEAIVIPTLGRDDGGLERFLTSAATAFVAGVNVAWRGVLDGAGFVELPTYAFDRRRFWLSGEGA AADASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFPGAGFVELAIRAGDEV GCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEADESGRRDVSIFSRPDSDSPWVCHAQGTLSTGSIEP GADLAAWPPAGATKVDIADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTGFGVHPAL LDAAMHALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRARLAPAQAPGTAASRAVSLELADGLGLPV LSVRAMVARSVSERQLRAAVSAAGPDRLFEVAWAPVTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHE ALAAVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQTEHPGRIVLIDSDAALDDSALT AALATGEPQVLLRDGTVYTARVHGSRAVDGIMTPPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQV RVALRAIATNFRDVMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSGTLVPGDVRLL QHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAAAGGVGMAAVQLARHLGLEVFATASRGK WDTLRAMGFDDDHIGDSRTLEFEDKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRD PGVVAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTTFDIRRGRAALRYLSQARHIGK VVMTVPGALSAGTVLITGGTGMAGSTLARHLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVI ACDAADRAALAGVIAGISAERPLSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAWNLHELTRDMNLS AFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRRAHGLPAISLAWGLWDQASAMTGGLDAADLARLGRD GILALSSDEAMELFDTALIVDEPFLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDSLAAAKSKSA LAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDKAFQELGFDSLTAVEMRNRLKTATGLALSP TLIFDYPTPNALAGYIRTELAGAPQETTHAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQMVAEGRDV LSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGIAPSEALAMDPQQRMFLELSWEAL ERAGIDPVKLRGSATGMFAGVYTQGYGMGAAPIAEGFRLTGQSSSVASGRVSYVLGLEGPAVSVDTACSS SLVALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRCKAYAGAADGTGFSEGGGMLVV ERLSDARRLGHPVLAVVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLG DPIEAQALLATYGQDRGQPLWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATLHVDEPSPHVDWSA GAVSLLTEAQPWPGERPRRAGVSSFGISGTNAHVIIEAVPAVEPAHADAPALPVLPWVVSAKSAAALRAQ AARLAEYVRAQGELDIADVGWTLAGRATFEHRAVVVGGDRDRLLAGLDELAADDPAASIIRGVATPAGKT VFVFPGQGSQTLGMGRQLHAGYPVFAEAFDAVVAELDRHLLRPLRDVIWGDDENVLNSTEFAQPALFAVE VALFRLLESWGVRPDFVMGHSIGELSAAHVAGVLSLQNAAVLVAARGRFMQALPEGGAMIAVQATEAQVR PLLGPDVGIAAVNGPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLA IDKPVIPIISNLTGQPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFLEVGPSSGLTAAIEETLA DAPVVTVSALRKDRPEPVALVNAVAQGWVCGMDVDWRGALGTGHLVDLPTYAFDRRRFWLSGDGAASDAA GLGLAAGDHALLGAVVELPASGGVLLTGRLSPASQGWLADHAVGGVVLFPGAGFVELAIRAGDEVGCGII DELNLAAPLVLPAGGSVAIQVVVDGPDDSGARAVSVFSRADAGAGWLLHAEGVLRAGSAQPATDLSAWPP VGAVPVDLGDGYEQLAERGYRYGPAFRGLTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDAALHAV MLASDGDDLPAGSMLVPFSWQRVSLHAAGAAAVRARIVPVSPSAVSIELADGLGLPVLSVASMVARPVTD QQLLAAVSNSGPDRLFELIWSAQPSTAVQPVSLLNWGATELDATDTDSDSGRFAVLFESAPVAGDVVTEV YAATRAVLPVLQSWLARDGAGTLVVSTRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHPGRIVLVDTDAPL DADAVAAVLAVGEPQTLLRNGTVYTARVLGSRAVGALLVPPEDGPWRLGMSSYGTIENLRLEPIPDADAP LGPGQVRVATSALAANFRDVMIALGLYPDPDAVMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTGTVA TTDQRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAVQLARHLGLEVF ATASRGKWDTLRDMGFDDDHLGDSRGLDFEDKFRAVTGGAGMDIVLDSLSGDSVDASLRLVAPGGIFLEM GKTDIRDPEVVAAEHPGVRYRAFDLFEAGPDRIARLLDELAAMFGEDVLRPLPVTRFDVRRAPAALRYLS QARHVGKVVMTMPDAWTAGTVLITGATGMAGSAVARHVVTRHGARNLVLVSRRGLDAPDAAELVAELTAA GAHAEVVACDAADREALAKVIADIPMQHPLTGVIHAAGVLDDAVVTSLTPQRIDTVLRAKVDAAWNLHEL TRDLDVGAFVMFSSIAGLAGASGQGNYAAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAAD LARFGRDGIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVDLINAPTRRQVDDS LAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIHPDRAFQELGFDSLTAVEMRNRLK AATGLALSPTLIFDYPNSAALAGYMYRELVGTSEQPTAAAAPGEAEIQRVVGSIPVKRLRQAGVLELLLA LANESTGTAQSATPAVTTEKDIADMDLDDLVNAALLDDDDE
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_2450 | - | - | 100% (4171) | erythronolide synthase, modules 3 and 4 |
M. avium 104 | MAV_3109 | - | 0.0 | 62.01% (2077) | RifB protein |
M. avium 104 | MAV_3108 | - | 0.0 | 58.79% (2133) | erythronolide synthase, modules 3 and 4 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2074c | pks12 | 0.0 | 80.68% (4177) | polyketide synthase pks12 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 36.85% (2567) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 80.90% (4177) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 59.43% (2053) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 36.16% (2597) | polyketide synthase |
M. marinum M | MMAR_3025 | pks12 | 0.0 | 80.27% (4206) | polyketide synthase, Pks12 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 36.43% (2539) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 34.17% (1876) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 79.86% (4210) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 37.33% (2550) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK -----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG- MAB_0939|M.abscessus_ATCC_1997 -----------------------MDSAENPIE-STPRFAIIGYAARFPG- MSMEG_0408|M.smegmatis_MC2_155 -----------------------MVSAEHPIE-PTPSFAIIGYAARFPG- Mvan_1003|M.vanbaalenii_PYR-1 ---------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG- MMAR_3025|M.marinum_M -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MUL_2266|M.ulcerans_Agy99 -MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGG Mb2074c|M.bovis_AF2122/97 -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG Rv2048c|M.tuberculosis_H37Rv -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MAV_2450|M.avium_104 MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF MAB_0939|M.abscessus_ATCC_1997 AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF MSMEG_0408|M.smegmatis_MC2_155 AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF Mvan_1003|M.vanbaalenii_PYR-1 AADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGF MMAR_3025|M.marinum_M VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF MUL_2266|M.ulcerans_Agy99 VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF Mb2074c|M.bovis_AF2122/97 VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF Rv2048c|M.tuberculosis_H37Rv VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF MAV_2450|M.avium_104 VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT MAB_0939|M.abscessus_ATCC_1997 VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET MSMEG_0408|M.smegmatis_MC2_155 VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS Mvan_1003|M.vanbaalenii_PYR-1 VEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGT MMAR_3025|M.marinum_M VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS MUL_2266|M.ulcerans_Agy99 VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS Mb2074c|M.bovis_AF2122/97 VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS Rv2048c|M.tuberculosis_H37Rv VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS MAV_2450|M.avium_104 VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ MAB_0939|M.abscessus_ATCC_1997 NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ MSMEG_0408|M.smegmatis_MC2_155 NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ Mvan_1003|M.vanbaalenii_PYR-1 RTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQ MMAR_3025|M.marinum_M ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE MUL_2266|M.ulcerans_Agy99 ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE Mb2074c|M.bovis_AF2122/97 ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE Rv2048c|M.tuberculosis_H37Rv ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE MAV_2450|M.avium_104 ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS MAB_0939|M.abscessus_ATCC_1997 GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS Mvan_1003|M.vanbaalenii_PYR-1 GPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFS MMAR_3025|M.marinum_M GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MUL_2266|M.ulcerans_Agy99 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS Mb2074c|M.bovis_AF2122/97 GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS Rv2048c|M.tuberculosis_H37Rv GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS MAV_2450|M.avium_104 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR MAB_0939|M.abscessus_ATCC_1997 HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR MSMEG_0408|M.smegmatis_MC2_155 NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR Mvan_1003|M.vanbaalenii_PYR-1 RARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIR MMAR_3025|M.marinum_M RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR MUL_2266|M.ulcerans_Agy99 RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR Mb2074c|M.bovis_AF2122/97 RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV Rv2048c|M.tuberculosis_H37Rv RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV MAV_2450|M.avium_104 RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS MAB_0939|M.abscessus_ATCC_1997 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS MSMEG_0408|M.smegmatis_MC2_155 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS Mvan_1003|M.vanbaalenii_PYR-1 GSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTP MMAR_3025|M.marinum_M GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MUL_2266|M.ulcerans_Agy99 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT Mb2074c|M.bovis_AF2122/97 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT Rv2048c|M.tuberculosis_H37Rv GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MAV_2450|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LGDPIEAQAAGAALGPGREPQ----RPLLIGSAKTNIGHLEAAAGIAGVI MAB_0939|M.abscessus_ATCC_1997 LGDPIEAQAAGAAYGIGRETN----DPLLIGSAKTNIGHLEAAAGIAGVI MSMEG_0408|M.smegmatis_MC2_155 LGDPIEAQAAGEVLGAGRAPE----EPLLIGSAKTNIGHLEAAAGIAGVI Mvan_1003|M.vanbaalenii_PYR-1 LGDPIEVQAAGAVLGVGREPD----RPLLIGSVKTNIGHLEAASGIAGLL MMAR_3025|M.marinum_M LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI MUL_2266|M.ulcerans_Agy99 LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI Mb2074c|M.bovis_AF2122/97 LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI Rv2048c|M.tuberculosis_H37Rv LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI MAV_2450|M.avium_104 LGDPIEAQALLATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPR MAB_0939|M.abscessus_ATCC_1997 KVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPR MSMEG_0408|M.smegmatis_MC2_155 KVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPR Mvan_1003|M.vanbaalenii_PYR-1 KVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSR MMAR_3025|M.marinum_M KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR MUL_2266|M.ulcerans_Agy99 KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR Mb2074c|M.bovis_AF2122/97 KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR Rv2048c|M.tuberculosis_H37Rv KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR MAV_2450|M.avium_104 KMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTP MAB_0939|M.abscessus_ATCC_1997 IAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTP MSMEG_0408|M.smegmatis_MC2_155 IAGVSSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTP Mvan_1003|M.vanbaalenii_PYR-1 VAGISSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTP MMAR_3025|M.marinum_M RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG MUL_2266|M.ulcerans_Agy99 RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG Mb2074c|M.bovis_AF2122/97 RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE Rv2048c|M.tuberculosis_H37Rv RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE MAV_2450|M.avium_104 RAGVSSFGISGTNAHVIIEAVPAVEPAHADAPALPVLP----WVVSAKSA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALMAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAA MAB_0939|M.abscessus_ATCC_1997 AALAQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAA MSMEG_0408|M.smegmatis_MC2_155 EALVRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESA Mvan_1003|M.vanbaalenii_PYR-1 DALAATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSV MMAR_3025|M.marinum_M SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGVDRDGL MUL_2266|M.ulcerans_Agy99 SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRDGL Mb2074c|M.bovis_AF2122/97 SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL Rv2048c|M.tuberculosis_H37Rv SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL MAV_2450|M.avium_104 AALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGGDRDRL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTE MAB_0939|M.abscessus_ATCC_1997 VELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETE MSMEG_0408|M.smegmatis_MC2_155 IELLGALADDRPA-PGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTE Mvan_1003|M.vanbaalenii_PYR-1 EELLGALAEDRPG-PGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTE MMAR_3025|M.marinum_M LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA MUL_2266|M.ulcerans_Agy99 LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA Mb2074c|M.bovis_AF2122/97 LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA Rv2048c|M.tuberculosis_H37Rv LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA MAV_2450|M.avium_104 LAGLDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPA MAB_0939|M.abscessus_ATCC_1997 PVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPA MSMEG_0408|M.smegmatis_MC2_155 PVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPA Mvan_1003|M.vanbaalenii_PYR-1 PVYREVMTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPA MMAR_3025|M.marinum_M PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRVDVVQPV MUL_2266|M.ulcerans_Agy99 PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRIDVVQPV Mb2074c|M.bovis_AF2122/97 PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV Rv2048c|M.tuberculosis_H37Rv PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV MAV_2450|M.avium_104 PVFAQHIQACEEAFAEFVDWSLIDALRGAP------GAAGMDRVDVVQPA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAE MAB_0939|M.abscessus_ATCC_1997 LFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAE MSMEG_0408|M.smegmatis_MC2_155 LFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAE Mvan_1003|M.vanbaalenii_PYR-1 LYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAE MMAR_3025|M.marinum_M LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL MUL_2266|M.ulcerans_Agy99 LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL Mb2074c|M.bovis_AF2122/97 LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL Rv2048c|M.tuberculosis_H37Rv LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL MAV_2450|M.avium_104 LFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RGRLFGSLPSGGRMAAVFAAAERVEALTDEY-PALSVAAYNG-ANTVLSG MAB_0939|M.abscessus_ATCC_1997 RGRLFSSLPAGGRMAAVFTDAERAERLTDEF-PSLSVAAYNG-ANTVLSG MSMEG_0408|M.smegmatis_MC2_155 RGRLFGSLPAGGRMAAVFTAPERAERLTDEY-PSLSVAAYNG-ANTVLSG Mvan_1003|M.vanbaalenii_PYR-1 RGRLFGSLPEGGRMAAVFAPADRVESCTVDS-PLLSVAAYNG-DNTVLSG MMAR_3025|M.marinum_M RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG MUL_2266|M.ulcerans_Agy99 RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG Mb2074c|M.bovis_AF2122/97 RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG Rv2048c|M.tuberculosis_H37Rv RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG MAV_2450|M.avium_104 RSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFT MAB_0939|M.abscessus_ATCC_1997 PAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYK MSMEG_0408|M.smegmatis_MC2_155 PAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYR Mvan_1003|M.vanbaalenii_PYR-1 PAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFG MMAR_3025|M.marinum_M EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL MUL_2266|M.ulcerans_Agy99 EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL Mb2074c|M.bovis_AF2122/97 EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR Rv2048c|M.tuberculosis_H37Rv EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR MAV_2450|M.avium_104 EGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK APQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKL MAB_0939|M.abscessus_ATCC_1997 TPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKV MSMEG_0408|M.smegmatis_MC2_155 EPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRV Mvan_1003|M.vanbaalenii_PYR-1 TPQRTLVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVRTLADLGCRL MMAR_3025|M.marinum_M SSRTAFFSSVTGSRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGHGYRT MUL_2266|M.ulcerans_Agy99 SSRTAFFSSVTGSRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGHGYRT Mb2074c|M.bovis_AF2122/97 STRTVFFSTVTGNRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQGYRT Rv2048c|M.tuberculosis_H37Rv STRTVFFSTVTGNRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQGYRT MAV_2450|M.avium_104 SSRIAFFSTVTGNRLD-TAGLDADYWYRNIRQTVQFDQTVRSAAEHGYRT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVEIGPRPVLTAAALSAWP----DPATSPRVIASLRRTTADQRQITEAVA MAB_0939|M.abscessus_ATCC_1997 LLEIGPQPVLTAAALRAWP----DPATAPRAIASLRRNTADHRQITEAAA MSMEG_0408|M.smegmatis_MC2_155 LLEIGPRPVLTATALAAWP----DPATTPQVLASLRPTTADHRQITEAVA Mvan_1003|M.vanbaalenii_PYR-1 LMEIGPQPVLTAAAMRTWP----GTVTAPRVAASMRRKGSDRRQITEALA MMAR_3025|M.marinum_M FIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA MUL_2266|M.ulcerans_Agy99 FIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFLASAA Mb2074c|M.bovis_AF2122/97 FIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFLLSAA Rv2048c|M.tuberculosis_H37Rv FIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFLLSAA MAV_2450|M.avium_104 FIESSPHPALVAGIEDTVNDSLPGD-TEAIVIPTLGRDDGGLERFLTSAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDSRE---PVAAAP MAB_0939|M.abscessus_ATCC_1997 DAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGDNRDAGNR MSMEG_0408|M.smegmatis_MC2_155 AAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAIDRDTQTAS Mvan_1003|M.vanbaalenii_PYR-1 QAYVAGHRPETAARQHGRGRLLDLPTYPFQHRAYWFP--------QGQAR MMAR_3025|M.marinum_M AAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDASGLGL MUL_2266|M.ulcerans_Agy99 AAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDASGLGL Mb2074c|M.bovis_AF2122/97 SAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGL Rv2048c|M.tuberculosis_H37Rv SAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVSGLGL MAV_2450|M.avium_104 TAFVAGVNVAWRGVLDG-AGFVELPTYAFDRRRFWLSGEGAAADASGLGL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QR---GARTETVRLLEDGRIEELAALLGGTV------------------- MAB_0939|M.abscessus_ATCC_1997 QQNNGGPRTEAVRLLEDGKIEELANLLGGVD------------------- MSMEG_0408|M.smegmatis_MC2_155 AGSVTPHRTQAVRLLEDGQIEELAALIDGET------------------- Mvan_1003|M.vanbaalenii_PYR-1 TAPTDPVHTETVRFLDEERIDELAALLDGPT------------------- MMAR_3025|M.marinum_M SAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFPGTGF MUL_2266|M.ulcerans_Agy99 SAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFPGTGF Mb2074c|M.bovis_AF2122/97 GASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGF Rv2048c|M.tuberculosis_H37Rv GASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGF MAV_2450|M.avium_104 GTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFPGAGF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------DDPFTFDVLNRLAAQHNQQRSTE-------------------- MAB_0939|M.abscessus_ATCC_1997 -------GDQQTLNVLTKLAAQHNLQRTTQ-------------------- MSMEG_0408|M.smegmatis_MC2_155 -------VDEQTLRVLNKLAARHNQQRSTH-------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------GSAQTVDVLSKLAARHRQQRGAQ-------------------- MMAR_3025|M.marinum_M VELAIRAGDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAAADSA MUL_2266|M.ulcerans_Agy99 VELAIRAVDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAAADSA Mb2074c|M.bovis_AF2122/97 VELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSN Rv2048c|M.tuberculosis_H37Rv VELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAGRDSN MAV_2450|M.avium_104 VELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEADESG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------SIADDRYQIRWETAAEPPVGADAADGITWLLVGDD MAB_0939|M.abscessus_ATCC_1997 ---------------TIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADA MSMEG_0408|M.smegmatis_MC2_155 ---------------VDPDARYEIRWDAIASAAASTGAAA--DWILVGDD Mvan_1003|M.vanbaalenii_PYR-1 ---------------SIADARYQIRWEKSEAPGAARPTTEATTWLLVTHD MMAR_3025|M.marinum_M ERSVSIYSR----TDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAI MUL_2266|M.ulcerans_Agy99 ERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPPAGAI Mb2074c|M.bovis_AF2122/97 SRGVSIFSR------ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAV Rv2048c|M.tuberculosis_H37Rv SRGVSIFSR------ADAQAGWLLHAEGILRPGSVEPGADLSVWPPAGAV MAV_2450|M.avium_104 RRDVSIFSR------PDSDSPWVCHAQGTLSTGSIEPGADLAAWPPAGAT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TDATRPLVDVLAARGHRY-------------------------------- MAB_0939|M.abscessus_ATCC_1997 AGAAQPLLDVLTARGQQH-------------------------------- MSMEG_0408|M.smegmatis_MC2_155 TAAVLEFADALTAGGHRH-------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 SRAAQPIAEVLERRGHPY-------------------------------- MMAR_3025|M.marinum_M AVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEVRLPEAAGSTSG MUL_2266|M.ulcerans_Agy99 AVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAGSTSG Mb2074c|M.bovis_AF2122/97 TVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGG Rv2048c|M.tuberculosis_H37Rv TVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGG MAV_2450|M.avium_104 KVDIADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAGGVTG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3025|M.marinum_M FGVHPALLDAALHTAVI----ANPDAELVLPFSWQGVSLHAAGAASVRVR MUL_2266|M.ulcerans_Agy99 FGVHPALLDAALHTAVI----ANPDADLVLPFSWQGVSLHAAGAASVRVR Mb2074c|M.bovis_AF2122/97 FGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASAVRAR Rv2048c|M.tuberculosis_H37Rv FGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASAVRAR MAV_2450|M.avium_104 FGVHPALLDAAMHALIVGHQIAGDTDEVALPFAWQGVSLHAAGASAVRAR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----------------------------RILGLPKSGAEEHELADTLRDA MAB_0939|M.abscessus_ATCC_1997 ----------------------------RVLALPVSDADEAELVEALRSA MSMEG_0408|M.smegmatis_MC2_155 ----------------------------QIVALPGSDADEAQLVDTLRAA Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------HIVGLPGSDADAAPAEEALRAT MMAR_3025|M.marinum_M IAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAVVSAS MUL_2266|M.ulcerans_Agy99 IAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAVVSAS Mb2074c|M.bovis_AF2122/97 IAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGS Rv2048c|M.tuberculosis_H37Rv IAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAAVSGS MAV_2450|M.avium_104 LAPAQAPGTAASRAVSLELADGLGLPVLSVRAMVARSVSERQLRAAVSAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQL MAB_0939|M.abscessus_ATCC_1997 ADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAEL MSMEG_0408|M.smegmatis_MC2_155 SAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFRAANDAEL Mvan_1003|M.vanbaalenii_PYR-1 VSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQLAATAGA MMAR_3025|M.marinum_M GPDRLFEVVWTPMTVAAT-DAAPAYELFESVAAEGDPLSGTYQRTHQALA MUL_2266|M.ulcerans_Agy99 GPDRLFEVVWTPMTVAAT-DAAPAYELFESIAADGDPLSGTYQRTHQALA Mb2074c|M.bovis_AF2122/97 GPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALA Rv2048c|M.tuberculosis_H37Rv GPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALA MAV_2450|M.avium_104 GPDRLFEVAWAPVTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHEALA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RSPMWL----------VTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQ MAB_0939|M.abscessus_ATCC_1997 RAPIWI----------VTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQ MSMEG_0408|M.smegmatis_MC2_155 RSPIWL----------VTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPH Mvan_1003|M.vanbaalenii_PYR-1 RAPIWL----------ITAGAQRITGDETVEPAQTSLWGFGRAAALEQPE MMAR_3025|M.marinum_M AVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPG MUL_2266|M.ulcerans_Agy99 AVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPG Mb2074c|M.bovis_AF2122/97 AVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPG Rv2048c|M.tuberculosis_H37Rv AVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQTEHPG MAV_2450|M.avium_104 AVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQTEHPG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----------------------------IWGG------------------ MAB_0939|M.abscessus_ATCC_1997 ----------------------------VWGG------------------ MSMEG_0408|M.smegmatis_MC2_155 ----------------------------IWGG------------------ Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------LWGG------------------ MMAR_3025|M.marinum_M RLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILV MUL_2266|M.ulcerans_Agy99 RLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAADGILV Mb2074c|M.bovis_AF2122/97 RIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILV Rv2048c|M.tuberculosis_H37Rv RIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAADAILV MAV_2450|M.avium_104 RIVLIDSDAALDDSALTAALATGEPQVLLRDGTVYTARVHGSRAVDGIMT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------LADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPR MAB_0939|M.abscessus_ATCC_1997 -------LADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPR MSMEG_0408|M.smegmatis_MC2_155 -------LADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPR Mvan_1003|M.vanbaalenii_PYR-1 -------LADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVAR MMAR_3025|M.marinum_M PPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRD MUL_2266|M.ulcerans_Agy99 PPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRD Mb2074c|M.bovis_AF2122/97 PPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD Rv2048c|M.tuberculosis_H37Rv PPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAANFRD MAV_2450|M.avium_104 PPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALRAIATNFRD MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LVHRDTLPSGKPLHLRADA------------------------------- MAB_0939|M.abscessus_ATCC_1997 LVRREELPSGKPLEVRSDA------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LVRRTGEPSDTPLPVREDR------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LTRCAEKANAAALELRREA------------------------------- MMAR_3025|M.marinum_M IMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLV MUL_2266|M.ulcerans_Agy99 IMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGSGTLV Mb2074c|M.bovis_AF2122/97 IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLV Rv2048c|M.tuberculosis_H37Rv IMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGSGTLV MAV_2450|M.avium_104 VMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGSGTLV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3025|M.marinum_M AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA MUL_2266|M.ulcerans_Agy99 AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA Mb2074c|M.bovis_AF2122/97 AGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAG Rv2048c|M.tuberculosis_H37Rv AGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVLIHAG MAV_2450|M.avium_104 PGDVRLLQHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVLVHAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3025|M.marinum_M TGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFE MUL_2266|M.ulcerans_Agy99 TGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRSLEFE Mb2074c|M.bovis_AF2122/97 TGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFE Rv2048c|M.tuberculosis_H37Rv TGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFE MAV_2450|M.avium_104 AGGVGMAAVQLARHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRTLEFE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3025|M.marinum_M EKFREVTGGRGVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGV MUL_2266|M.ulcerans_Agy99 EKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIRDPGV Mb2074c|M.bovis_AF2122/97 DKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV Rv2048c|M.tuberculosis_H37Rv DKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV MAV_2450|M.avium_104 DKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIRDPGV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_3025|M.marinum_M IAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVR MUL_2266|M.ulcerans_Agy99 IAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTAFDVR Mb2074c|M.bovis_AF2122/97 IAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTTFDVR Rv2048c|M.tuberculosis_H37Rv IAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTTFDVR MAV_2450|M.avium_104 VAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTTFDIR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------------------------TYLVTGGLGSLGLEIAG MAB_0939|M.abscessus_ATCC_1997 ---------------------------------TYLVTGGLGSIGLEIAG MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------TYLVTGGLGAIGLEVAG Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------------TYLVTGGLGALGLEVAE MMAR_3025|M.marinum_M RAPAALRYLSQARHIGKVVMTMPADQGGALGGGTVLITGGTGMAGSALAR MUL_2266|M.ulcerans_Agy99 RAPAALRYLSQARHVGKVVMTMPADQGGALGGGTVLITGGTGMAGSALAR Mb2074c|M.bovis_AF2122/97 RAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGSAVAR Rv2048c|M.tuberculosis_H37Rv RAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGSAVAR MAV_2450|M.avium_104 RGRAALRYLSQARHIGKVVMTVPG----ALSAGTVLITGGTGMAGSTLAR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK YLAA-NGAGHLVLTSRRTPDEAAASRIEALRERHGCEVRVVTADVADAHA MAB_0939|M.abscessus_ATCC_1997 YLAG-RGAKHLVLTSRREPGEAARQRIDALAA-QGCEVRAVTADVADGHD MSMEG_0408|M.smegmatis_MC2_155 YLAS-HGAGHVVLTSRREPGDDARRRLDGLREQYACDVRVITADVADAHD Mvan_1003|M.vanbaalenii_PYR-1 FLAS-HGAGHLVLTGRRSASDTVRQRIDAMRERFDCQVLVATADVADRDD MMAR_3025|M.marinum_M HLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPA MUL_2266|M.ulcerans_Agy99 HLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAADRPA Mb2074c|M.bovis_AF2122/97 HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAA Rv2048c|M.tuberculosis_H37Rv HVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAA MAV_2450|M.avium_104 HLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVIACDAADRAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVDRVFAGKVWGAW MAB_0939|M.abscessus_ATCC_1997 VARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAGKVWGAW MSMEG_0408|M.smegmatis_MC2_155 VARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAW Mvan_1003|M.vanbaalenii_PYR-1 VARLFSTMRSELPPLAGIVHAAGEIGTSPLRTLDDAEMDRVFAGKVWGAV MMAR_3025|M.marinum_M LAKVIAEIPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAW MUL_2266|M.ulcerans_Agy99 LAKVIAENPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAW Mb2074c|M.bovis_AF2122/97 LAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAW Rv2048c|M.tuberculosis_H37Rv LAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAW MAV_2450|M.avium_104 LAGVIAGISAERP-LSGVIHAAGVLDDAMITSLTPERIDAVLRAKVDAAW MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK HLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAANAFLDGLAWRLRE MAB_0939|M.abscessus_ATCC_1997 HLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAANAFLDGLAWRLRE MSMEG_0408|M.smegmatis_MC2_155 HLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFLDGLAWRLRE Mvan_1003|M.vanbaalenii_PYR-1 YLCEEVADMG--LDFFLATSSIASVWGSHGQTAYGAANAFLDGLADSLRA MMAR_3025|M.marinum_M NLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRA MUL_2266|M.ulcerans_Agy99 NLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAAHRRA Mb2074c|M.bovis_AF2122/97 HLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRA Rv2048c|M.tuberculosis_H37Rv HLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRA MAV_2450|M.avium_104 NLHELTRDMN--LSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAAHRRA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QGVAGVSVNFGPWS-----AGMADAQSRARLEQRGIKTLSPADALAGLSD MAB_0939|M.abscessus_ATCC_1997 QGIAGTSVNFGPWS-----AGMADAESRARLEQRGIKTLSPTDALAGLAD MSMEG_0408|M.smegmatis_MC2_155 RGVTAVSVNFGPWA-----AGMADAESRARLEQRGVRTLSPAEALAGMAD Mvan_1003|M.vanbaalenii_PYR-1 RGIPGISVNFGPWA-----AGMADAKAREQLSRRGVKTLAPADALAGMAD MMAR_3025|M.marinum_M HGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDT MUL_2266|M.ulcerans_Agy99 HGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDT Mb2074c|M.bovis_AF2122/97 HGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALSTAEALELFDT Rv2048c|M.tuberculosis_H37Rv HGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALELFDT MAV_2450|M.avium_104 HGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGILALSSDEAMELFDT MLBr_00135|M.leprae_Br4923 ------------------MTASVEGADQK--------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQG MAB_0939|M.abscessus_ATCC_1997 VVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLA--G MSMEG_0408|M.smegmatis_MC2_155 VVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAA Mvan_1003|M.vanbaalenii_PYR-1 VIAASTA---HAVVARIDWATFLPVYQLQRRRAFLSQLEREVPDVPD--A MMAR_3025|M.marinum_M ALIVNQA-----FLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQVDDA MUL_2266|M.ulcerans_Agy99 ALIVNQA-----FLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQIDAA Mb2074c|M.bovis_AF2122/97 AMIVDEP-----FLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDS Rv2048c|M.tuberculosis_H37Rv AMIVDEP-----FLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDS MAV_2450|M.avium_104 ALIVDEP-----FLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDA MAB_0939|M.abscessus_ATCC_1997 VAGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDA MSMEG_0408|M.smegmatis_MC2_155 APATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEA Mvan_1003|M.vanbaalenii_PYR-1 SAPAPSGTTRFVEELTLAPVEQRRKLVLEYLRAAVAEVTRVDAAEIRDEA MMAR_3025|M.marinum_M LAAAKSKSALAHRLHGLPEPEQHAVVLDLVRSHIATVLGTITPEAIDPDK MUL_2266|M.ulcerans_Agy99 LATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAIDPDK Mb2074c|M.bovis_AF2122/97 VAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDK Rv2048c|M.tuberculosis_H37Rv VAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDK MAV_2450|M.avium_104 LAAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDK MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYLLGDVL MAB_0939|M.abscessus_ATCC_1997 GFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVL MSMEG_0408|M.smegmatis_MC2_155 GFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLLVEVL Mvan_1003|M.vanbaalenii_PYR-1 GFFDLGMDSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVLGDVL MMAR_3025|M.marinum_M AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELA MUL_2266|M.ulcerans_Agy99 AFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELA Mb2074c|M.bovis_AF2122/97 AFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELA Rv2048c|M.tuberculosis_H37Rv AFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELA MAV_2450|M.avium_104 AFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELA MLBr_00135|M.leprae_Br4923 -------------------------------------SEKLISYLKKVVV TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPG-APNPEAFWDLLSGG MAB_0939|M.abscessus_ATCC_1997 GLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPG-APDPEAFWDVLSGG MSMEG_0408|M.smegmatis_MC2_155 GLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPG-APDPESFWELLAGG Mvan_1003|M.vanbaalenii_PYR-1 GLSEHTV--AQPDTPSTVRTDDPIAIVGMACRFPG-ADDTDAFWSVLAEG MMAR_3025|M.marinum_M GAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR MUL_2266|M.ulcerans_Agy99 GAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDMLMAR Mb2074c|M.bovis_AF2122/97 GLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG Rv2048c|M.tuberculosis_H37Rv GLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDMLIQG MAV_2450|M.avium_104 GAPQETT----HAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQMVAEG MLBr_00135|M.leprae_Br4923 ELDETRA----RLREYEQRATEPVAVVGIGCRFPGGVDSPDRLWDVVSEC TH_4621|M.thermoresistible__bu ------------VNIVGDTPVNAVAVIGMACRLPGGIDSPQRLWEALLRG :.:*::.:.** ** ..: :*. : Mflv_0405|M.gilvum_PYR-GCK VDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFFGL MAB_0939|M.abscessus_ATCC_1997 VDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFFGI MSMEG_0408|M.smegmatis_MC2_155 VDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFFGI Mvan_1003|M.vanbaalenii_PYR-1 ADLIREIPDDR-FDINEFYDPDPEAAGKIYSRYGGFLDGVDGFDPEFFGI MMAR_3025|M.marinum_M RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFDPAFFGV MUL_2266|M.ulcerans_Agy99 RDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFEPAFFGV Mb2074c|M.bovis_AF2122/97 RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV Rv2048c|M.tuberculosis_H37Rv RDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPAFFGV MAV_2450|M.avium_104 RDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPAFFGI MLBr_00135|M.leprae_Br4923 RDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAGFFGI TH_4621|M.thermoresistible__bu DDMVTEIPVDR-WDADDYFDPEPGVPGRTVSRWGAFLDDVAGFDPEFFGI * : :.* ** :* ::*:* . * :* *.*:* *:. ***: Mflv_0405|M.gilvum_PYR-GCK SPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGVAANEYA MAB_0939|M.abscessus_ATCC_1997 SPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGVGANEYA MSMEG_0408|M.smegmatis_MC2_155 SPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGVAANEYA Mvan_1003|M.vanbaalenii_PYR-1 SPREAVWIDPQQRLVLETAWEGLERAGYSAAALRGSRSGVYVGVGANEYS MMAR_3025|M.marinum_M GPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYG MUL_2266|M.ulcerans_Agy99 GPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMTQGYG Mb2074c|M.bovis_AF2122/97 GPSEALAMDPQQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG Rv2048c|M.tuberculosis_H37Rv GPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMTQGYG MAV_2450|M.avium_104 APSEALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYTQGYG MLBr_00135|M.leprae_Br4923 APSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTGIFAPSYG TH_4621|M.thermoresistible__bu SEREAISIDPQQRLLLETSWEAMEHAGLTPADVEGSSTGVFVGLSHDDYA . *.: ::**:*:.** **.:* ** . :.** :*::.*: *. Mflv_0405|M.gilvum_PYR-GCK HLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTACSSSLV MAB_0939|M.abscessus_ATCC_1997 HLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTACSSALV MSMEG_0408|M.smegmatis_MC2_155 HLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTACSSALV Mvan_1003|M.vanbaalenii_PYR-1 HLLSGGSLDGIEAQFITGNALNVIAGRVSFTLGLEGPAVAVDTACSSSLV MMAR_3025|M.marinum_M MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV MUL_2266|M.ulcerans_Agy99 MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV Mb2074c|M.bovis_AF2122/97 MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV Rv2048c|M.tuberculosis_H37Rv MFAAEP----VEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACSSSLV MAV_2450|M.avium_104 MGAAPI----AEGFRLTGQSSSVASGRVSYVLGLEGPAVSVDTACSSSLV MLBr_00135|M.leprae_Br4923 SRDTGG----LQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDTACSSSLV TH_4621|M.thermoresistible__bu LLTSDAG-ALEEAYGFTGSAFSMASGRIAYRLGVHGPAVTVDTACSSSLL : : :** . :**::: **..****:*******:*: Mflv_0405|M.gilvum_PYR-GCK AVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFD MAB_0939|M.abscessus_ATCC_1997 AVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGRCKTFD MSMEG_0408|M.smegmatis_MC2_155 AVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFD Mvan_1003|M.vanbaalenii_PYR-1 AVHQACQGLQSGDCDLALAGGVNVLLSPATTIATSRARMLSPDGRCKTFD MMAR_3025|M.marinum_M ALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFA MUL_2266|M.ulcerans_Agy99 ALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRCKAFA Mb2074c|M.bovis_AF2122/97 ALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFA Rv2048c|M.tuberculosis_H37Rv ALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRCKAFA MAV_2450|M.avium_104 ALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRCKAYA MLBr_00135|M.leprae_Br4923 AIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRCKAFA TH_4621|M.thermoresistible__bu AVHMACRSLQVGESDLALAGGAMVMLEPRKYTSASGLGMLSPTGRCHAFD *:* * .*: *:.*:*****. : * * *: ***::: Mflv_0405|M.gilvum_PYR-GCK ASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGASSGLTV MAB_0939|M.abscessus_ATCC_1997 ASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGASSGLTV MSMEG_0408|M.smegmatis_MC2_155 ASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGASSGLTV Mvan_1003|M.vanbaalenii_PYR-1 AAADGYVRGEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDGASGGLTV MMAR_3025|M.marinum_M GAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTA MUL_2266|M.ulcerans_Agy99 GAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASNGLTA Mb2074c|M.bovis_AF2122/97 AAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTA Rv2048c|M.tuberculosis_H37Rv AAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASNGLTA MAV_2450|M.avium_104 GAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQDGASNGLTA MLBr_00135|M.leprae_Br4923 RAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASNGLTA TH_4621|M.thermoresistible__bu VAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVRGTAANQDGRTENIST :*** .** :::::**.** * .. : *:: .::.**** : .::. Mflv_0405|M.gilvum_PYR-GCK PNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQAAAAAYA MAB_0939|M.abscessus_ATCC_1997 PNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAAAAYG MSMEG_0408|M.smegmatis_MC2_155 PNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQAAAAAYG Mvan_1003|M.vanbaalenii_PYR-1 PNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQAAGAVLG MMAR_3025|M.marinum_M PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MUL_2266|M.ulcerans_Agy99 PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG Mb2074c|M.bovis_AF2122/97 PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG Rv2048c|M.tuberculosis_H37Rv PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MAV_2450|M.avium_104 PNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALLATYG MLBr_00135|M.leprae_Br4923 PNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQALLATYG TH_4621|M.thermoresistible__bu PSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTPVGDPIEYNSLTQVYG *. :* : :.*: **: . :. :*.***.*.:***** :: . . Mflv_0405|M.gilvum_PYR-GCK GARDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQSL MAB_0939|M.abscessus_ATCC_1997 GSRDAD----RPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQSL MSMEG_0408|M.smegmatis_MC2_155 AGRDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVLPQSL Mvan_1003|M.vanbaalenii_PYR-1 AGRDPD----RPLLMGSVKTNVGHLESASGVAGLIKVVLSLQHEMLPRHL MMAR_3025|M.marinum_M QDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATL MUL_2266|M.ulcerans_Agy99 QDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVLPATL Mb2074c|M.bovis_AF2122/97 QDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL Rv2048c|M.tuberculosis_H37Rv QDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL MAV_2450|M.avium_104 QDRGQP------LWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELLPATL MLBr_00135|M.leprae_Br4923 QGRPAD----QPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVMPATL TH_4621|M.thermoresistible__bu KTGPCA--------LTSVKTNFGHAESAAGALGMMKAILALQHGVVPQNL : *:*:*.** ::*:*. *::* : :::: :* * Mflv_0405|M.gilvum_PYR-GCK HFDTPSPHIPWDSLPVRVVDTAMPWQ---PNGRPRRAGVSSFGFTGTNAH MAB_0939|M.abscessus_ATCC_1997 HFDNPSPHIPWESLPVRVVDKAIPWQ---ANGRPRRAGVSSFGFTGTNAH MSMEG_0408|M.smegmatis_MC2_155 HFENPSPHIPWDALPVRVIDEPVPWQ---TNGRVRRAGVSSFGFTGTNAH Mvan_1003|M.vanbaalenii_PYR-1 HFKTPSPHIPWDRLAVRVVAEPTPWR---ADGRPRRAGVSSFGFSGTNAH MMAR_3025|M.marinum_M HVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAH MUL_2266|M.ulcerans_Agy99 HVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISGTNAH Mb2074c|M.bovis_AF2122/97 HVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISGTNAH Rv2048c|M.tuberculosis_H37Rv HVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISGTNAH MAV_2450|M.avium_104 HVDEPSPHVDWSAGAVSLLTEAQPWP----GERPRRAGVSSFGISGTNAH MLBr_00135|M.leprae_Br4923 HVDEPSPRVDWTTGAVSVLTEARDWS---VEGRPRRAGVSSFGISGTNAH TH_4621|M.thermoresistible__bu HFTRLPDEMAAIETNLFVPQATTLWP--VREGCPRRAAVSSYGMSGTNVH *. . .: : : . * ***.***:*::***.* Mflv_0405|M.gilvum_PYR-GCK VLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALV MAB_0939|M.abscessus_ATCC_1997 VLIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSPEALA MSMEG_0408|M.smegmatis_MC2_155 VLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSPEALV Mvan_1003|M.vanbaalenii_PYR-1 VVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAGVLPISARSPEALT MMAR_3025|M.marinum_M VIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSGSALG MUL_2266|M.ulcerans_Agy99 VIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSGSALG Mb2074c|M.bovis_AF2122/97 VIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSESALR Rv2048c|M.tuberculosis_H37Rv VIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSESALR MAV_2450|M.avium_104 VIIEAVP---------------AVEPAHADAPALPVLPWVVSAKSAAALR MLBr_00135|M.leprae_Br4923 VILEEAPTP------------VEASYSTADQQRLSVVPWVVSGRSTAALM TH_4621|M.thermoresistible__bu AVLEQAPEP------------VQRPEESADTDAAGPLVFALSSTSAEELR .::* * :*. * * Mflv_0405|M.gilvum_PYR-GCK ALAQRYETWLTAH-PEADLADVCRTAGTGRSHFEHRAALVVDSVESARIA MAB_0939|M.abscessus_ATCC_1997 AVAQRYESWLAAH-PDVDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREG MSMEG_0408|M.smegmatis_MC2_155 ELARRYDDWLSAT-PGLDIADVCHTAGVGRSHFEYRAALVVDSVERAREG Mvan_1003|M.vanbaalenii_PYR-1 ALARRYESWLTAH-PDADIADVCYTAGAGRSHFEHRAALVVDSVDGARDL MMAR_3025|M.marinum_M AQAARLAAHVRSH-DELDVADVGWSLA-GRSTFEHRAVVLGVDRDGLLAG MUL_2266|M.ulcerans_Agy99 AQAARLAAHVRSH-DELDVADVGWSLA-GRSTFEHRAVVLGADRDGLLAG Mb2074c|M.bovis_AF2122/97 GQAARLAAYVRGD-DGLDVADVGWSLA-GRSVFEHRAVVVGGDRDRLLAG Rv2048c|M.tuberculosis_H37Rv GQAARLAAYVRGD-DGLDVADVGWSLA-GRSVFEHRAVVVGGDRDRLLAG MAV_2450|M.avium_104 AQAARLAEYVRAQ-GELDIADVGWTLA-GRATFEHRAVVVGGDRDRLLAG MLBr_00135|M.leprae_Br4923 AQASRLAFYVQAD-PEVDPVDVGCALA-ARSVFEHRAVVVGESREQLIAG TH_4621|M.thermoresistible__bu RTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVIADGVEALTAG * * : . *: : . *: *:.:: . : Mflv_0405|M.gilvum_PYR-GCK LTDLAQNRLR-PGVVRGEHLNHPTTAWMFTGQGSQYPGMARELFDTEPVF MAB_0939|M.abscessus_ATCC_1997 LLELAQNRLR-PGVVRGEHTNHPTTAWLFTGQGSQYPGMARELFDAEPVF MSMEG_0408|M.smegmatis_MC2_155 LAALAEGRTP-AGVVRGEHVHRPTTAWLFTGQGSQYPGMARELFDTQPVF Mvan_1003|M.vanbaalenii_PYR-1 LAGLAEDRLG-PGAVRGVCGDPPKTAWLFTGQGSQYPGMARELFDTEPVF MMAR_3025|M.marinum_M LDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVF MUL_2266|M.ulcerans_Agy99 LDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVF Mb2074c|M.bovis_AF2122/97 LDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVF Rv2048c|M.tuberculosis_H37Rv LDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGMGLHAGYPVF MAV_2450|M.avium_104 LDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQTLGMGRQLHAGYPVF MLBr_00135|M.leprae_Br4923 LAGLAVGESG-AGVAIGQAAPLGKTVVVFPGQGAQRIGMGRELCSQLPVF TH_4621|M.thermoresistible__bu LREVADGDAP---YQPAVGMDDKAPVWVFSGQGSQWAGMGAELLATEQVF * :* . . .. :*.***:* **. * ** Mflv_0405|M.gilvum_PYR-GCK ADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFA MAB_0939|M.abscessus_ATCC_1997 AETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHTSFAQPALFA MSMEG_0408|M.smegmatis_MC2_155 AQTVRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHTSFAQPALFA Mvan_1003|M.vanbaalenii_PYR-1 RDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----GQTLRHTSYAQPALFA MMAR_3025|M.marinum_M AEAFNTVVGELDRHLLRPLREVIWGH-------DENLLNTTEFAQPALFA MUL_2266|M.ulcerans_Agy99 AEAFNTVVGELDRHLLRPLREVIWGH-------DENLLNTTEFAQPALFA Mb2074c|M.bovis_AF2122/97 AEAFNTVVGELDRHLLRPLREVMWGH-------DENLLNSTEFAQPALFA Rv2048c|M.tuberculosis_H37Rv AEAFNTVVGELDRHLLRPLREVMWGH-------DENLLNSTEFAQPALFA MAV_2450|M.avium_104 AEAFDAVVAELDRHLLRPLRDVIWGD-------DENVLNSTEFAQPALFA MLBr_00135|M.leprae_Br4923 AEEFDAVTGELDRHMRLPLRDVVWGA-------DAGLLDSTEFAQPALFA TH_4621|M.thermoresistible__bu AAKIAEIEPLVARESGFSVTEAMTAS---------ETVTGIDRVQPTLFA . : .: :.: : . .**:*** Mflv_0405|M.gilvum_PYR-GCK VEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGR MAB_0939|M.abscessus_ATCC_1997 VEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGR MSMEG_0408|M.smegmatis_MC2_155 VEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDGARLMAERGR Mvan_1003|M.vanbaalenii_PYR-1 IEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFGLEDGARLVADRGR MMAR_3025|M.marinum_M VEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGR MUL_2266|M.ulcerans_Agy99 VEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGR Mb2074c|M.bovis_AF2122/97 VEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGR Rv2048c|M.tuberculosis_H37Rv VEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLENAAVLVAARGR MAV_2450|M.avium_104 VEVALFRLLESWGVRPDFVMGHSIGELSAAHVAGVLSLQNAAVLVAARGR MLBr_00135|M.leprae_Br4923 VEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPADAAMLVVARGR TH_4621|M.thermoresistible__bu IQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDGVKVICRRSR :::.* .: *. *:***:*: :** ***.:. :.. :: *.* Mflv_0405|M.gilvum_PYR-GCK LFGSLPEGGRMVAVFADAKRVEQVAADF--PRVSVGAYNGPN-TVLSGPG MAB_0939|M.abscessus_ATCC_1997 LFGGLPAGGRMVAVFSDAKHVEQIAGEF--PRVSVGAYNGPN-TVLSGPG MSMEG_0408|M.smegmatis_MC2_155 MFGSLPEGGRMVAVFADAEHVEQVAGEF--PRVSVGAYNGPN-TVLSGPG Mvan_1003|M.vanbaalenii_PYR-1 LFGGLPVGGRMVAVFTDAEVVEDFADEF--PQVSVAAYNGPN-TVLAGPA MMAR_3025|M.marinum_M LMQALPDGGAMIAVQATEQEVLPLLG----AQVSIAAINGPASVVISGAQ MUL_2266|M.ulcerans_Agy99 LMQALPDGGAMIAVQATEQEVLPLLG----AQVSIATINGPASVVISGAQ Mb2074c|M.bovis_AF2122/97 LMQALPAGGAMVAVQAAEEEVRPLLS----AEVDIAAVNGPASLVISGAQ Rv2048c|M.tuberculosis_H37Rv LMQALPAGGAMVAVQAAEEEVRPLLS----AEVDIAAVNGPASLVISGAQ MAV_2450|M.avium_104 FMQALPEGGAMIAVQATEAQVRPLLG----PDVGIAAVNGPAAVVISGDH MLBr_00135|M.leprae_Br4923 LMQSMPAGGTMWAVAASEDEVVSLLG----EGVGIAAINAPESVVISGPQ TH_4621|M.thermoresistible__bu LCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASPESTVIGGAT : :. .* * *: * . * :.. .* *:.* Mflv_0405|M.gilvum_PYR-GCK EDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAP MAB_0939|M.abscessus_ATCC_1997 EDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESYAAQVQFAAP MSMEG_0408|M.smegmatis_MC2_155 EDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAYAAQFQFAAP Mvan_1003|M.vanbaalenii_PYR-1 SDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEFESCAARLAYAAP MMAR_3025|M.marinum_M DAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAP MUL_2266|M.ulcerans_Agy99 DAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAP Mb2074c|M.bovis_AF2122/97 NAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRP Rv2048c|M.tuberculosis_H37Rv NAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAVAAGIAIGRP MAV_2450|M.avium_104 DAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTVAAGLAIDKP MLBr_00135|M.leprae_Br4923 AAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRVAAQVEVRKP TH_4621|M.thermoresistible__bu DTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEILADLQPMTP . :* : .. * ** ::*:::*: . . * Mflv_0405|M.gilvum_PYR-GCK TLPLVCNRTGAVLTGQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM MAB_0939|M.abscessus_ATCC_1997 TLPLVCNRTGAVLTAQTPIDGQYWRRHSRQPVQFAESVRTVAALGCSVLM MSMEG_0408|M.smegmatis_MC2_155 TLPLVCNRTGAVLTGQTPLDAQYWRRHSRQPVQFAESVRTVAALGCSVLM Mvan_1003|M.vanbaalenii_PYR-1 TRPLVCNRTGAVVTGPGVIDAQYWRRHARQPVQFAESVRTLADLGCSVLM MMAR_3025|M.marinum_M TIGIISNLTG-QLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFL MUL_2266|M.ulcerans_Agy99 TIGIISNLTG-QLAGEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFL Mb2074c|M.bovis_AF2122/97 TIGVISNVTG-QLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFL Rv2048c|M.tuberculosis_H37Rv TIGVISNVTG-QLAGDDFGSAAYWRRHIRQAVRFADSVRFAQAAGGSRFL MAV_2450|M.avium_104 VIPIISNLTG-QPAADDFGSPEYWKCHVRDAVRFADSVRFAQSAGATRFL MLBr_00135|M.leprae_Br4923 QIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRFVDSARHLQTLGATHFI TH_4621|M.thermoresistible__bu TVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQAALEDGFRVFG . *. . ** : *:*. : : * : Mflv_0405|M.gilvum_PYR-GCK EIGPQPVLTGAAVQVWPEHLAAPR--AIASLRKGVADRRQIADALAAAYI MAB_0939|M.abscessus_ATCC_1997 EIGPQPVLTGAAVQVWPEHLAPPR--AIVSLRKGVEDRRQIADALASAYV MSMEG_0408|M.smegmatis_MC2_155 EIGPQPVLTGAAVQVWPEHMAAPR--AVASLRKGVADRRQIADALASAYV Mvan_1003|M.vanbaalenii_PYR-1 EIGPQPFLIAAALRVWPESAATPR--AIPSLRKGPDARRQLAEAVAAAYI MMAR_3025|M.marinum_M EVGPSSGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSAVAGVFV MUL_2266|M.ulcerans_Agy99 EVGPSIGLTASIEEVLSDAAVTNPVATASALRKDRPEPVSLVSALAGVFV Mb2074c|M.bovis_AF2122/97 EVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEPATLTNAVAQGFV Rv2048c|M.tuberculosis_H37Rv EVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEPATLTNAVAQGFV MAV_2450|M.avium_104 EVGPSSGLTAAIEETLADAPVV----TVSALRKDRPEPVALVNAVAQGWV MLBr_00135|M.leprae_Br4923 ESGPSSGLMGAIEQSLAPAEAV----VVSMMGKDRPELASVLGAAGQLFA TH_4621|M.thermoresistible__bu ELSPHPLLTRAVEQTARGLDMPVA--ALPAMRREQEMPHGVRTMVGDLFA * .* * : . . : : : . : Mflv_0405|M.gilvum_PYR-GCK GGHKPDFAALHEQR-GVRLELPTYPFQRRRFWPK---SAGMAIDGRVGAS MAB_0939|M.abscessus_ATCC_1997 SGHRPNFAALQRHP-RRTVELPTYPFQRRRFWPK---SSGTAIEG--GGG MSMEG_0408|M.smegmatis_MC2_155 GGHRPDFAAVHRQP-RRPVELPTYPFQRRRFWPK---ASSIAVDG---GT Mvan_1003|M.vanbaalenii_PYR-1 AGHRLDFTGHDGGP-HRRLPLPTYPFQHRSYWPK---TAGIRSDG----S MMAR_3025|M.marinum_M AGTAVDWRAVVGQS--NFVELPTYAFERRRFWLS-GDAVAADAAGLGLQA MUL_2266|M.ulcerans_Agy99 AGTAVDWRAVVGQS--HFVELPTYAFERRRFWLS-GDAVPADAAGLGLQA Mb2074c|M.bovis_AF2122/97 TGMDLDWRAVVGEA--QFVELPTYAFQRRRFWLS-GDGVAADAASLGLAA Rv2048c|M.tuberculosis_H37Rv TGMDLDWRAVVGEA--QFVELPTYAFQRRRFWLS-GDGVAADAAGLGLAA MAV_2450|M.avium_104 CGMDVDWRGALGTG--HLVDLPTYAFDRRRFWLS-GDGAASDAAGLGLAA MLBr_00135|M.leprae_Br4923 TGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDGTASVSGLGLGS TH_4621|M.thermoresistible__bu AGAAVDFAALYPSG--RLVDAPLPTWTRRKLVLS--RENGEQQTRGGCTI * :: . : * .: :* . Mflv_0405|M.gilvum_PYR-GCK AGSGILGSGKD-LASGD-SVYTSRLSVKTQPWLSDHVIYGTVVVPGATYA MAB_0939|M.abscessus_ATCC_1997 LPSGILGRGED-LASGD-SVYISRLSVRSQPWLSDHVIYGTVVVPGATYA MSMEG_0408|M.smegmatis_MC2_155 AASGILGSGKD-LASGD-TIYTSRLSVKSQPWLADHVIYGTVVVPGATYA Mvan_1003|M.vanbaalenii_PYR-1 SGSGLLGSAQD-LASGD-IVHTSRLSVKTQPWLSDHVIYGTVVVPGATYA MMAR_3025|M.marinum_M GEHALLGAVVELPASGG-VVLTGRLSLAAQGWLADHAVGGVVIFPGAGFV MUL_2266|M.ulcerans_Agy99 GEHALLGAVVELPASGG-VVLTGRLSLAAQGWLADHAVGGVVIFPGAGFV Mb2074c|M.bovis_AF2122/97 SEHALLGAVIDLPASGG-VVLTGRLSPSVQGWLADHSVAGVTIFPGAGFV Rv2048c|M.tuberculosis_H37Rv SEHALLGAVIDLPASGG-VVLTGRLSPSVQGWLADHSVAGVTIFPGAGFV MAV_2450|M.avium_104 GDHALLGAVVELPASGG-VLLTGRLSPASQGWLADHAVGGVVLFPGAGFV MLBr_00135|M.leprae_Br4923 TEHALLGAVVERPDSGG-VVLTGRLSLANQPWLADHVIGGVVLFPGAGFV TH_4621|M.thermoresistible__bu TVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQIHTVAALPGAAYC :** . : . *. * **:** : .. .*** : Mflv_0405|M.gilvum_PYR-GCK AMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTVHPSVDGE-SKFQ MAB_0939|M.abscessus_ATCC_1997 AMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQLTLHPLEDGSGSKFQ MSMEG_0408|M.smegmatis_MC2_155 AMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTLHPADGGSVLSFQ Mvan_1003|M.vanbaalenii_PYR-1 AMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQLMLHRTDDADGWTFE MMAR_3025|M.marinum_M ELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVS MUL_2266|M.ulcerans_Agy99 ELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVS Mb2074c|M.bovis_AF2122/97 ELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGPDESGVRGVS Rv2048c|M.tuberculosis_H37Rv ELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGPDESGVRGVS MAV_2450|M.avium_104 ELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVVVDGPDDSGARAVS MLBr_00135|M.leprae_Br4923 ELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESSRRAVS TH_4621|M.thermoresistible__bu EMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVASAVEPGTLEFA :.: * : : : . Mflv_0405|M.gilvum_PYR-GCK VHSRPYGERGAE-WALNAEGVVASGVGD---SPAAAGDLEDPVDEAIERL MAB_0939|M.abscessus_ATCC_1997 VHSRPYGERDVD-WSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERM MSMEG_0408|M.smegmatis_MC2_155 IHSRPYGERGAD-WSLNAEGTVDTAGSD---PDAAADEQSDPVDEVIERL Mvan_1003|M.vanbaalenii_PYR-1 VHSRPYGDRDAD-WSRNASGTVAAGVGD-----AAPDAAADPVDNAIERL MMAR_3025|M.marinum_M VYSR--GDAGSD-WVLHAEGSLGSGSPE-----PATDLSTWPPVGAVE-- MUL_2266|M.ulcerans_Agy99 VYSR--GDAGSD-WVLHAEGSLGSGSPE-----PATDLSTWPPVGAVE-- Mb2074c|M.bovis_AF2122/97 VYSR--GDVGTG-WVLHAEGALRAGSAE-----PTADLAMWPPAGAVP-- Rv2048c|M.tuberculosis_H37Rv VYSR--GDVGTG-WVLHAEGALRAGSAE-----PTADLAMWPPAGAVP-- MAV_2450|M.avium_104 VFSR--ADAGAG-WLLHAEGVLRAGSAQ-----PATDLSAWPPVGAVP-- MLBr_00135|M.leprae_Br4923 VYSR--GDQSHGGWLLNAEGLLEVDAAE-----ATVDLSLWPPEGAES-- TH_4621|M.thermoresistible__bu VETAKDGEHERR--ATAVLGAADDTEPP-----QAHDIDALLAEHPTR-- : : .: . * Mflv_0405|M.gilvum_PYR-GCK NRMRPQELFETFADLELAWGPTWSGSLKSLWLG--EGEAIGDILVGAELA MAB_0939|M.abscessus_ATCC_1997 ERMRPMELFEIFADLELAWGPTWSGSLKSLWLG--EGEAIGDVLVGEELA MSMEG_0408|M.smegmatis_MC2_155 ERMRPQDLFETFADLELAWGPTWSGSLKSLWLG--DGEAVGDILVGAELA Mvan_1003|M.vanbaalenii_PYR-1 TRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVG--TGEAVGDIAVGAELG MMAR_3025|M.marinum_M --VENADGYQQLAERGYGYGPAFRG-LNAMWRR--GDEVFAEVALPADAG MUL_2266|M.ulcerans_Agy99 --VENADGYQQLAERGYGYGPAFRG-LNAMWRR--GDEVFAEVALPADAG Mb2074c|M.bovis_AF2122/97 --VEVADGYQQLAERGYGYGPAFRG-LTAMWRR--GDEVFAEVALPADAG Rv2048c|M.tuberculosis_H37Rv --VEVADGYQQLAERGYGYGPAFRG-LTAMWRR--GDEVFAEVALPADAG MAV_2450|M.avium_104 --VDLGDGYEQLAERGYRYGPAFRG-LTSMWRR--GDEIFAEVNLPTDAG MLBr_00135|M.leprae_Br4923 --VDISDAYPQLAERGYAYGPAFQG-LVAIWRR--GSELFAEVVAPT--G TH_4621|M.thermoresistible__bu --IEGDELRQWFDQRGVQFGPAFTGLTAARIPEGTVTSVLAEVGLPGQIR : : : :**:: . : . ..:: Mflv_0405|M.gilvum_PYR-GCK EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQE MAB_0939|M.abscessus_ATCC_1997 EQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKE MSMEG_0408|M.smegmatis_MC2_155 EQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAE Mvan_1003|M.vanbaalenii_PYR-1 EHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADPELFLPLRYGRVEVRE MMAR_3025|M.marinum_M VSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHA MUL_2266|M.ulcerans_Agy99 VSVSGFGIHPVMLDAALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHA Mb2074c|M.bovis_AF2122/97 VSVTGFGVHPVLLDAALHAVVLSAESAERG---QGSVLVPFSWQGVSLHA Rv2048c|M.tuberculosis_H37Rv VSVTGFGVHPVLLDAALHAVVLSAESAERG---QGSVLVPFSWQGVSLHA MAV_2450|M.avium_104 VSTTGFGVHPVMLDAALHAVMLASDGDDLP---AGSMLVPFSWQRVSLHA MLBr_00135|M.leprae_Br4923 VVVDGMGMHPALLDAVLHALGLAIENTQAT----TEMRLPFCWRGVSLHA TH_4621|M.thermoresistible__bu SQQAPYGIHPALLDACFQSVAAHPDVQGAG----SGLLLPLGVRRLQAFG :**.::* : :*: : Mflv_0405|M.gilvum_PYR-GCK KMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFTVKRAPRE MAB_0939|M.abscessus_ATCC_1997 KMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPRE MSMEG_0408|M.smegmatis_MC2_155 KMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKRAPRE Mvan_1003|M.vanbaalenii_PYR-1 RMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGGIREFTVKRAPRE MMAR_3025|M.marinum_M AGASAVRARIAPAG------PSAVSIELSDGLGLPVLSVASMLARPVTDQ MUL_2266|M.ulcerans_Agy99 AGASAVRARIAPAG------PSAVSIELSDGLGLPVLSVASMLARPVTDQ Mb2074c|M.bovis_AF2122/97 AGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASMLARPVTDQ Rv2048c|M.tuberculosis_H37Rv AGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASMLARPVTDQ MAV_2450|M.avium_104 AGAAAVRARIVPVS------PSAVSIELADGLGLPVLSVASMVARPVTDQ MLBr_00135|M.leprae_Br4923 GGAGRVRARFTSAG------ADAIAVDIADSAGLPVLTVRSLVTRAMTAE TH_4621|M.thermoresistible__bu PTRGARYCYARVTDAD--GSKAEADLDVLDEHGNVLLRVQGLLMGGAAAD . :: * * : : : . : Mflv_0405|M.gilvum_PYR-GCK ALLRGLGGDA---TRLLYTLGWHEVPVP----ESGDGAAPQGTWLIGGFD MAB_0939|M.abscessus_ATCC_1997 ALLRGLGGDA---TRLLYTLGWHEVAVPPVAGEGEESAASIGTWLIAGFD MSMEG_0408|M.smegmatis_MC2_155 ALLRGLGGDA---TRLLYTLGWHEVPPP------PSADDAVGTWLIAGFD Mvan_1003|M.vanbaalenii_PYR-1 ALLRGLGADA---TRLIYRVGWRETSPP---VRDDGALGPSSTWLVAGLD MMAR_3025|M.marinum_M QLRAAVSGAG---PDRLFGVDWTAQPSA-------ELQP----VPVRIWG MUL_2266|M.ulcerans_Agy99 QLRAAVSGAG---PDRLFGVDWTAQPSA-------ELQP----VPVRIWG Mb2074c|M.bovis_AF2122/97 QLRAAVSSSG---PDRLFEVTWSPQPSA-------AVEP----LPVCAWG Rv2048c|M.tuberculosis_H37Rv QLRAAVSSSG---PDRLFEVTWSPQPSA-------AVEP----LPVCAWG MAV_2450|M.avium_104 QLLAAVSNSG---PDRLFELIWSAQPST-------AVQP----VSLLNWG MLBr_00135|M.leprae_Br4923 QLRTAVTAAGGALEQGPMDLVWSPIPLS-------SDGHGGGLPSVVSWA TH_4621|M.thermoresistible__bu GDDRDRVLGER-----LLTIEWQRRDLP-------EADSAAGKWLLVSTS : * . : Mflv_0405|M.gilvum_PYR-GCK ELAVSVPGCIPADR----------------TNPESLRQLLTDAHGRGLPF MAB_0939|M.abscessus_ATCC_1997 ELAAKVPGCIPLNRE---------------TDPELLGEVLVAAKERGVPF MSMEG_0408|M.smegmatis_MC2_155 ELAAKVPGCVPIDRN---------------TDLQVLGEVLSQAHARGAGF Mvan_1003|M.vanbaalenii_PYR-1 ALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFALADERRAPV MMAR_3025|M.marinum_M AVESEGDDDPG--------------------------------------- MUL_2266|M.ulcerans_Agy99 TVESEGDDDPG--------------------------------------- Mb2074c|M.bovis_AF2122/97 TTEDS--------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TTEDS--------------------------------------------- MAV_2450|M.avium_104 ATELDATDTDSDSGR----------------------------------- MLBr_00135|M.leprae_Br4923 DYCAGRGNDTG--------------------------------------- TH_4621|M.thermoresistible__bu ATADVSATRLSDALKQAG----------AESTSMCWPQQADHADNVDRFR Mflv_0405|M.gilvum_PYR-GCK SGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQ---GGEVKLP MAB_0939|M.abscessus_ATCC_1997 SGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLP MSMEG_0408|M.smegmatis_MC2_155 SGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQ---GPSVKLP Mvan_1003|M.vanbaalenii_PYR-1 AGVVLGVTGRARPEE-PSADFAARLEAQIRDVLGAVHSLS---ALGAKPA MMAR_3025|M.marinum_M ASVVFESVPQAG-------EVVAGVYAATAAVLEVLRSWLS-----RDGA MUL_2266|M.ulcerans_Agy99 ASVVFESVPQAG-------EVVAGVYAATAAVLEVLRSWLS-----RDGA Mb2074c|M.bovis_AF2122/97 AAVVFESVPLAG-------DVVAGVYAATSSVLDVLQSWLT-----RDGA Rv2048c|M.tuberculosis_H37Rv AAVVFESVPLAG-------DVVAGVYAATSSVLDVLQSWLT-----RDGA MAV_2450|M.avium_104 FAVLFESAPVAG-------DVVTEVYAATRAVLPVLQSWLA-----RDGA MLBr_00135|M.leprae_Br4923 -VVVWEFGSASAGAQ-APVDSVAAVYSATHAALQVLQFWFG-----QDRA TH_4621|M.thermoresistible__bu AGIADGVTGVVVLTGPKNGNPDDAAARRGSDYVRHLVRITRELAEIDGDA : : : . Mflv_0405|M.gilvum_PYR-GCK GGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGS MAB_0939|M.abscessus_ATCC_1997 GGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGS MSMEG_0408|M.smegmatis_MC2_155 GGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGS Mvan_1003|M.vanbaalenii_PYR-1 AGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLIAEEPGLRCLLVDLDGS MMAR_3025|M.marinum_M GQLVITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPG-RIVLVDTD-A MUL_2266|M.ulcerans_Agy99 GQLIITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPG-RIVLVDTD-A Mb2074c|M.bovis_AF2122/97 GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDSD-A Rv2048c|M.tuberculosis_H37Rv GVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDSD-A MAV_2450|M.avium_104 GTLVVSTRGAMTLPGEDVTDLAGAAVWGLVRSAQTEHPG-RIVLVDTD-A MLBr_00135|M.leprae_Br4923 GTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSG-KIVLIDTD-S TH_4621|M.thermoresistible__bu PRLFVVTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADD * : *. . : :.: *: * *.. : :* Mflv_0405|M.gilvum_PYR-GCK PQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGH----LTVPR MAB_0939|M.abscessus_ATCC_1997 PEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGH----LTVPR MSMEG_0408|M.smegmatis_MC2_155 SEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGH----LTLPR Mvan_1003|M.vanbaalenii_PYR-1 EDAGPALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQ----LAIPR MMAR_3025|M.marinum_M QLDEHAVAAVLAAG---EPQVLWRNGEVYTARVHGSRAVAG----LLVPP MUL_2266|M.ulcerans_Agy99 QLDEHAVAAVLAAG---EPQVLWRNGEVYTARVHGSRAVAG----LLVPP Mb2074c|M.bovis_AF2122/97 PLDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGG----LLVPP Rv2048c|M.tuberculosis_H37Rv PLDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGG----LLVPP MAV_2450|M.avium_104 PLDADAVAAVLAVG---EPQTLLRNGTVYTARVLGSRAVGA----LLVPP MLBr_00135|M.leprae_Br4923 AVD---VAVLADLG---ESQLLVRCNTVHAARLS--PAPQL----LALPV TH_4621|M.thermoresistible__bu ADLDRVAVQLLGGG--AEDETAWRDGQWYTARLSLSPLRPEERKQAVVDC . : * : * . ..*: : Mflv_0405|M.gilvum_PYR-GCK GGD-YVLAPTERGAIDNLRLTDS-EVPPPAE-GYVQVRVEAAGLNFRDVL MAB_0939|M.abscessus_ATCC_1997 GSD-YVLAPTERGAIDNLRITEK-EVPAPDE-GYVQVRVEAAGLNFRDVL MSMEG_0408|M.smegmatis_MC2_155 GGD-FVLAPTERGAIDNLRLTET-DVPEPDE-GYVQVRVEAAGLNFRDVL Mvan_1003|M.vanbaalenii_PYR-1 GTD-YVLAPTERGVLDNLRVSET-EVTAPPE-GHVQVRVEAAGLNFRDVL MMAR_3025|M.marinum_M GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM MUL_2266|M.ulcerans_Agy99 GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM Mb2074c|M.bovis_AF2122/97 SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVM Rv2048c|M.tuberculosis_H37Rv SDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANFRDVM MAV_2450|M.avium_104 EDGPWRLGMSSYGTIENLRLEPIPDADAPLGPGQVRVATSALAANFRDVM MLBr_00135|M.leprae_Br4923 GESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVV TH_4621|M.thermoresistible__bu ERDGMRLEIRTPGDLETMELAAFDRVPPGPG--QIEVAVTASSINFADVL * * :: : : . :.* * . ** **: Mflv_0405|M.gilvum_PYR-GCK NVLGLYPGDPG---PIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFA- MAB_0939|M.abscessus_ATCC_1997 NVLGLYPGDPG---PIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFG- MSMEG_0408|M.smegmatis_MC2_155 NVLGLYPGDPG---PIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFA- Mvan_1003|M.vanbaalenii_PYR-1 NALGLYPGDPG---PIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFA- MMAR_3025|M.marinum_M IALGLYPDPDA---AMGVEGAGVVVETASTDGRFAVGDRVVGLFPEGTG- MUL_2266|M.ulcerans_Agy99 IALGLYPDPDA---AMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGTG- Mb2074c|M.bovis_AF2122/97 IALGLYPDPDA---VMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG- Rv2048c|M.tuberculosis_H37Rv IALGLYPDPDA---VMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG- MAV_2450|M.avium_104 IALGLYPDPDA---VMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTG- MLBr_00135|M.leprae_Br4923 AALGMYPGQAP---PLGAEGAGVVIEIGPEVTGVAVGDAVMG-FLGGAG- TH_4621|M.thermoresistible__bu IAFGRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWS .:* ** :* : .* * . :*: * * . Mflv_0405|M.gilvum_PYR-GCK SRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRLSF-DWAQVKSGDKVLI MAB_0939|M.abscessus_ATCC_1997 SRFNVPAQFLAPIPDGISGVEAATIPAAALTVRLSF-DWAQLKPGDKVLI MSMEG_0408|M.smegmatis_MC2_155 SRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAF-DWAQLKPGDKVLI Mvan_1003|M.vanbaalenii_PYR-1 SRVNVPVQFLAPVPEGISAVAAATTPAAVLTAGLAF-DWAALRAGDRVLI MMAR_3025|M.marinum_M TIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV MUL_2266|M.ulcerans_Agy99 TIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILV Mb2074c|M.bovis_AF2122/97 TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLADVQPGQRVLI Rv2048c|M.tuberculosis_H37Rv TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLI MAV_2450|M.avium_104 TVATTDQRLLVKVPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLV MLBr_00135|M.leprae_Br4923 PLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLI TH_4621|M.thermoresistible__bu TFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLI . : . :* * **: ... *. .: * * .*: :*: Mflv_0405|M.gilvum_PYR-GCK HAASGGVGLAAVQMAQQCGAEVYATAST-FKRATLRKLG--VKHVYDSRT MAB_0939|M.abscessus_ATCC_1997 HAASGGVGLAAIQMAQQFGAEVFATAST-FKRATLRKLG--VKYVYDSRT MSMEG_0408|M.smegmatis_MC2_155 HAASGGVGLAAIQMAQQSGAEVFATAST-FKRSTLRRLG--VKYVYDSRT Mvan_1003|M.vanbaalenii_PYR-1 HAASGGVGLAAVQLARQRGATVFATASG-YKRPMLRAMG--VDHVYDSRT MMAR_3025|M.marinum_M HAATGGVGMAAVQLARHWGLEVFATASK-GKWDTLRAMGFDEDHIGDSRS MUL_2266|M.ulcerans_Agy99 HAATGGVGMAAVQLARHWGLEVFATASK-GKWDTLRAMGFDEDHIGDSRS Mb2074c|M.bovis_AF2122/97 HAGTGGVGMAAVQLARHLGLEVFATASK-GKWDTLRAMGFDDDHISDSRS Rv2048c|M.tuberculosis_H37Rv HAGTGGVGMAAVQLARHLGLEVFATASK-GKWDTLRAMGFDDDHISDSRS MAV_2450|M.avium_104 HAAAGGVGMAAVQLARHLGLEVFATASR-GKWDTLRDMGFDDDHLGDSRG MLBr_00135|M.leprae_Br4923 HAGTGGVGMAAVQFARHWGVEIFVTASR-GKWDTLRDMGFDDDHIGDSRT TH_4621|M.thermoresistible__bu HSATGGVGLAAIAIARSVGAQIYATAGSPARRDLLRDMG--IEHVYDSRS *:.:****:**: :*: * ::.**. : ** :* .:: *** Mflv_0405|M.gilvum_PYR-GCK TDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDI MAB_0939|M.abscessus_ATCC_1997 TDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDI MSMEG_0408|M.smegmatis_MC2_155 TDFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDI Mvan_1003|M.vanbaalenii_PYR-1 TDFADQILADTDGAGVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDI MMAR_3025|M.marinum_M LEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI MUL_2266|M.ulcerans_Agy99 LEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI Mb2074c|M.bovis_AF2122/97 LEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI Rv2048c|M.tuberculosis_H37Rv LEFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDI MAV_2450|M.avium_104 LDFEDKFRAVTGGAGMDIVLDSLSGD-SVDASLRLVAPGGIFLEMGKTDI MLBr_00135|M.leprae_Br4923 LEFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDI TH_4621|M.thermoresistible__bu TAFADEIRRDTDGYGVDVVLNSLPGA-AQRAGLELLSFGGRFIEIGKRDI * ::: *.* *.*:**:**.. * :. * * *:.* ** Mflv_0405|M.gilvum_PYR-GCK WTVEQMAAA--RPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWT MAB_0939|M.abscessus_ATCC_1997 WTTEQMAQS--RPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWT MSMEG_0408|M.smegmatis_MC2_155 WSHEQMAEA--RPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWT Mvan_1003|M.vanbaalenii_PYR-1 WSPEQMAAA--RPDIDYEVLALDAVMQQDPDRIQLLLADLADSLARGETA MMAR_3025|M.marinum_M REAAVVAQQ--HTGVRYRAFDLFEAG---PDHIAQILAELAALFSEDALR MUL_2266|M.ulcerans_Agy99 REAAVVAQQ--HTGVRYRAFDLFEAG---PDHIAQILAELAALFSEDVLR Mb2074c|M.bovis_AF2122/97 RDPGVIAQQ--YPGVRYRAFDLFEAG---PDRIAQILAELATLFGDGVLR Rv2048c|M.tuberculosis_H37Rv RDPGVIAQQ--YPGVRYRAFDLFEPG---PDRIAQILAELATLFGDGVLR MAV_2450|M.avium_104 RDPEVVAAE--HPGVRYRAFDLFEAG---PDRIARLLDELAAMFGEDVLR MLBr_00135|M.leprae_Br4923 RDAQEIAAN--YPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQVLH TH_4621|M.thermoresistible__bu YGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYRLTADGVLP :. .: :. . * * :: :* : Mflv_0405|M.gilvum_PYR-GCK PLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNP-LQPQPDRSYLITGG MAB_0939|M.abscessus_ATCC_1997 PLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNP-LAPRPDRTYLITGG MSMEG_0408|M.smegmatis_MC2_155 PLPAEIYPITEARSAFRRMQQARHIGKIVLQVPKP-LQPQQDRSYLITGG Mvan_1003|M.vanbaalenii_PYR-1 PLPFEAYPLAEATTAFRRMQQARHTGKIILQMPKP-LQPHGDRSYLITGG MMAR_3025|M.marinum_M PLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGG MUL_2266|M.ulcerans_Agy99 PLPVTTFDVRRAPAALRYLSQARHVGKVVLTMP----DAWAAGTVLITGG Mb2074c|M.bovis_AF2122/97 PLPVTTFDVRRAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGG Rv2048c|M.tuberculosis_H37Rv PLPVTTFDVRCAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGG MAV_2450|M.avium_104 PLPVTRFDVRRAPAALRYLSQARHVGKVVMTMP----DAWTAGTVLITGA MLBr_00135|M.leprae_Br4923 RLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGA TH_4621|M.thermoresistible__bu MPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVP----------------- : : * :*:* :. *.* **:: :* Mflv_0405|M.gilvum_PYR-GCK LGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHV MAB_0939|M.abscessus_ATCC_1997 LGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHV MSMEG_0408|M.smegmatis_MC2_155 LGAIG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHT Mvan_1003|M.vanbaalenii_PYR-1 LGALG-LHAAAYLAQLGAGDIVLTGRRMPDAATERAISEIAERYHCRIHT MMAR_3025|M.marinum_M TGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQV MUL_2266|M.ulcerans_Agy99 TGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQV Mb2074c|M.bovis_AF2122/97 TGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQV Rv2048c|M.tuberculosis_H37Rv TGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQV MAV_2450|M.avium_104 TGMAGSAVARHVVTRHGARNLVLVSRRGLDAPDAAELVAELTAAGAHAEV MLBr_00135|M.leprae_Br4923 SGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGAVELAAELVGAGAKIQV TH_4621|M.thermoresistible__bu --------------HTGRADVVVPPEQASPFRSDGAYIVTGGMGGLGLYL * .:*: .: Mflv_0405|M.gilvum_PYR-GCK FTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRT MAB_0939|M.abscessus_ATCC_1997 FTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRT MSMEG_0408|M.smegmatis_MC2_155 YAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRT Mvan_1003|M.vanbaalenii_PYR-1 FAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQQSPERFRT MMAR_3025|M.marinum_M VACDAADRAALAKLIADIPVQHP-LSAVIHTAGALDDAVVTSLTPERMET MUL_2266|M.ulcerans_Agy99 VACDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVVTSLTPERIET Mb2074c|M.bovis_AF2122/97 VACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDV Rv2048c|M.tuberculosis_H37Rv VACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDV MAV_2450|M.avium_104 VACDAADREALAKVIADIPMQHP-LTGVIHAAGVLDDAVVTSLTPQRIDT MLBr_00135|M.leprae_Br4923 VACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDT TH_4621|M.thermoresistible__bu AGEMAAAGAGCIVLNGRSAPSGEALRTIEQLRAAGTEVIVECGXXXRGQP .. : . : : : .. : : * Mflv_0405|M.gilvum_PYR-GCK ALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLD MAB_0939|M.abscessus_ATCC_1997 TLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLD MSMEG_0408|M.smegmatis_MC2_155 TLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLD Mvan_1003|M.vanbaalenii_PYR-1 TLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANYATANAVLD MMAR_3025|M.marinum_M VLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLD MUL_2266|M.ulcerans_Agy99 VLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLD Mb2074c|M.bovis_AF2122/97 VLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD Rv2048c|M.tuberculosis_H37Rv VLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLD MAV_2450|M.avium_104 VLRAKVDAAWNLHELTRDLDVGAFVMFSSIAGLAGASGQGNYAAGNSFLD MLBr_00135|M.leprae_Br4923 VLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLD TH_4621|M.thermoresistible__bu VEVAVPTELRHADEHPD----------RRGAQLCDEFARGEQGAQRNQHR . . .. . : . .:.: .: . Mflv_0405|M.gilvum_PYR-GCK GLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANIS---AQGLIPLEPS MAB_0939|M.abscessus_ATCC_1997 GLIAQRRAQGLPATGINFGPWGQGGMASSEAATANIS---AQGLIPLDPS MSMEG_0408|M.smegmatis_MC2_155 GLVAKRRAQGLVATGINFGPWGQGGMASSEAATANIT---AQGLIPLDPS Mvan_1003|M.vanbaalenii_PYR-1 GLVAHRKARGLPATGVNWGPWAQGGMATSDAARANLG---AQGLIPLEPT MMAR_3025|M.marinum_M GLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSD MUL_2266|M.ulcerans_Agy99 GLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSD Mb2074c|M.bovis_AF2122/97 ALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARDGIVAMSSA Rv2048c|M.tuberculosis_H37Rv ALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSA MAV_2450|M.avium_104 GLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARFGRDGIVAMSSQ MLBr_00135|M.leprae_Br4923 GLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPA TH_4621|M.thermoresistible__bu TDAGEGQRDAHPPGAVGHDQPDPGALSDTGLDERGGQFPGVGVQIPVADP : . .: . . . .: Mflv_0405|M.gilvum_PYR-GCK AALTAMAEVVANGTAQATVLKANWQR-AAKVLGSSRPPILDLVLPSAVGE MAB_0939|M.abscessus_ATCC_1997 AALAALAEVVANGTGQATILKANWQR-AAKVLGSSRPPILDLVLPSAVGE MSMEG_0408|M.smegmatis_MC2_155 AALHALAEVIANGSGQATVLKANWQR-AAKVLGSARPPILDLVLPSAAGE Mvan_1003|M.vanbaalenii_PYR-1 AALNALGEIVAHGIASAVVLKANWQR-AAKLLGATRPPILDHVLPSAVAA MMAR_3025|M.marinum_M EALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRR MUL_2266|M.ulcerans_Agy99 EALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRR Mb2074c|M.bovis_AF2122/97 DALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRR Rv2048c|M.tuberculosis_H37Rv DALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRR MAV_2450|M.avium_104 EALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVDLINAPTRR MLBr_00135|M.leprae_Br4923 QALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRR TH_4621|M.thermoresistible__bu GVGIDHRGAVRVDSGVPAQQGVDGEVVRHRTLSSVRSGRSSRWTAPGSRC . : . : : .. . Mflv_0405|M.gilvum_PYR-GCK ITGDS--------ELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPA MAB_0939|M.abscessus_ATCC_1997 VTGDS--------ELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPPA MSMEG_0408|M.smegmatis_MC2_155 ATGDS--------ELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPPA Mvan_1003|M.vanbaalenii_PYR-1 GPGDS--------ALLKQLQDVPEAQRGSFVTEHLQRELQQILGLAQPPA MMAR_3025|M.marinum_M QVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDA MUL_2266|M.ulcerans_Agy99 QVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDA Mb2074c|M.bovis_AF2122/97 QVDDSLAAAKSKSALAHRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEA Rv2048c|M.tuberculosis_H37Rv QVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEA MAV_2450|M.avium_104 QVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEA MLBr_00135|M.leprae_Br4923 QIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPED TH_4621|M.thermoresistible__bu G-------------SGRRYGGESCRRTTGPAAGAAARRGRTRRRRRPRRP :: . . . Mflv_0405|M.gilvum_PYR-GCK ATS--RFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAE MAB_0939|M.abscessus_ATCC_1997 ATS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAE MSMEG_0408|M.smegmatis_MC2_155 ASS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAE Mvan_1003|M.vanbaalenii_PYR-1 ATG--RFLELGMDSLMAVELRNRLVGQFGSGFTITATAVFDYPTIGALAE MMAR_3025|M.marinum_M IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG MUL_2266|M.ulcerans_Agy99 IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG Mb2074c|M.bovis_AF2122/97 IDPDRAFQDLGFDSLTAVEMRNRLKSATG--LSLSPTLIFDYPNSAALAG Rv2048c|M.tuberculosis_H37Rv IDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAG MAV_2450|M.avium_104 IHPDRAFQELGFDSLTAVEMRNRLKAATG--LALSPTLIFDYPNSAALAG MLBr_00135|M.leprae_Br4923 IDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLPPTVIFDHPTPTAVAE TH_4621|M.thermoresistible__bu PPPPDRVRHRAGPAHGPVRR------------------------------ . . . : .:. Mflv_0405|M.gilvum_PYR-GCK YLVAQLPDAETP-------------------------------------Q MAB_0939|M.abscessus_ATCC_1997 YLVGQLPDADAE-------------------------------------S MSMEG_0408|M.smegmatis_MC2_155 YLVGQLPDAEAP-------------------------------------E Mvan_1003|M.vanbaalenii_PYR-1 YLAAQTPESTEE-------------------------------------G MMAR_3025|M.marinum_M YMHRELVGASPQSDITAEAPGEAELQRVVASIPVKRLRQAGVLELLLALA MUL_2266|M.ulcerans_Agy99 YMHRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQAGVLELLLALA Mb2074c|M.bovis_AF2122/97 YMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALA Rv2048c|M.tuberculosis_H37Rv YMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQAGVLDLLLALA MAV_2450|M.avium_104 YMYRELVGTSEQ-PTAAAAPGEAEIQRVVGSIPVKRLRQAGVLELLLALA MLBr_00135|M.leprae_Br4923 YVAQQMLKSRPA-------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAP-------QSESEPGPDVTE----------------- MAB_0939|M.abscessus_ATCC_1997 AEAPPAVESAEAESGAGPAAASDAVSELKE--------- MSMEG_0408|M.smegmatis_MC2_155 TA------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 TEMKTADPDGQPATVGHADVVLQTS-------------- MMAR_3025|M.marinum_M NETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE- MUL_2266|M.ulcerans_Agy99 NETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE- Mb2074c|M.bovis_AF2122/97 NETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- Rv2048c|M.tuberculosis_H37Rv NETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- MAV_2450|M.avium_104 NESTGTAQSATPAVTTEKDIADMDLDDLVNAALLDDDDE MLBr_00135|M.leprae_Br4923 -ESGDETSQAVEPKVEEVSVHA----------------- TH_4621|M.thermoresistible__bu ---------------------------------------