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MFYAAFPPEINSGRMYTGPGSGPLLAAAAAWDAVAAELQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVA PYVTWMGATAAQAAQAATQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAESQY AEMWAQDATAMDGYASSSAAASEVTPFAEPPQVVNAAGLASQAAVVGQAAAASPAATVQDLLATGPISWL LQLGADLSTGYTAAVTALLNGLFGPSGATTYLTLYNAIKTPLNFTTGFNDIGLLINFPASQFLKFAPHPG LGPLPKDALGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRGTLVGKLTVPPSWAAATPTIRTVAAALSAAG PEAVPAAALGEGGLLSSMAVAGMLGSAFGAGAPDAYKRAGVRSRLTPLKDLKDATSPEKLKRLVAQISEK PESVQHHTVDQEGLDSLLEQLAKKPGIHAVHLSKGDKAKVVPTDAQPG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2685 | - | - | 100% (468) | PPE family protein, PPE30 |
| M. marinum M | MMAR_1460 | - | 0.0 | 71.22% (469) | PPE family protein |
| M. marinum M | MMAR_2684 | - | 9e-81 | 46.80% (391) | PPE family protein, PPE32 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1830 | PPE30 | 1e-120 | 52.64% (473) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-35 | 43.37% (196) | PPE protein |
| M. tuberculosis H37Rv | Rv1802 | PPE30 | 1e-120 | 52.64% (473) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-47 | 35.26% (397) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 1e-33 | 31.37% (424) | PPE family protein |
| M. avium 104 | MAV_2909 | - | 1e-163 | 64.98% (474) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-36 | 33.26% (433) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-36 | 39.33% (239) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3071 | - | 0.0 | 98.72% (468) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-38 | 32.44% (450) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
MMAR_2685|M.marinum_M -------------MFYAAFPPEINSGRMYTGPGSGPLLAAAAAWDAVAAE
MUL_3071|M.ulcerans_Agy99 -------------MFYAAFPPEINSGRVYTGPGSEPLLAAAAAWDAVAAE
MAV_2909|M.avium_104 -------------MFYGAFPPEFNSGRMYSGPGAGSFVAAATAWQNLAAE
Mb1830|M.bovis_AF2122/97 -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
Rv1802|M.tuberculosis_H37Rv -------------MDFGVLPPEINSGRMYAGPGSGPMLAAAAAWDGLATE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: . .** :* : ***. .:::*. * :: :
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
MMAR_2685|M.marinum_M LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATAAQAAQAA
MUL_3071|M.ulcerans_Agy99 LQSTAAAFSSVIASLTSGPWIGPSSLAMAAAVAPYVTWMGATATQAAQAA
MAV_2909|M.avium_104 LQSAAASYSSVLSGLTAGPWVGPSSLAMASAAAPYVAWMQQTAAQAAETA
Mb1830|M.bovis_AF2122/97 LQSTAADYGSVISVLT-GVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
Rv1802|M.tuberculosis_H37Rv LQSTAADYGSVISVLT-GVWSGQSSGTMAAAAAPYVAWMSATAALAREAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
::* . : : * *: . :** *: :: . *
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
MMAR_2685|M.marinum_M TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
MUL_3071|M.ulcerans_Agy99 TQATAAATAYETAFAAHVPPVEIAANRAQLAMLVATNLFGQNTAAIAAAE
MAV_2909|M.avium_104 AQATAAATAYETAFAAHVPPAVIAENRALLAQLVATNIFGQNTAAIAANE
Mb1830|M.bovis_AF2122/97 AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
Rv1802|M.tuberculosis_H37Rv AQASAAAAAYEAAFAATVPPPVVAANRAELAVLAATNIFGQNTGAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.:* ** :*:: . : *: * :*::* *: .** *
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMST-YQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSAS
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMST-YQAVAGTAVMSAPASSPAPLLLAPGVSEAADAM
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMAT-YQSVSGAALAATPTSAPAPSVLLPGVGEAGRAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMAT-YQAVSGAALAATPTATPAPFVLAPGVGEAGRAA
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGV-YQGVSSAALAATTPTQPSPMIMAPG-GEMSRMS
MMAR_2685|M.marinum_M SQYAEMWAQDATAMDG-YASSSAAASEVTPFAEPPQVVNAAGLASQAAVV
MUL_3071|M.ulcerans_Agy99 SQYAEMWAQDATAMDG-YASSSAAASEVTPVAEPRQVVNAAGLASQAAVV
MAV_2909|M.avium_104 AQYGEFWAQDATAMDTYFAASATAANKLTEFGPAPKTTNEAAQPMQAAAV
Mb1830|M.bovis_AF2122/97 ARYAEMWAQDAAAMYG-YAGSSSVATQVTPFAAPPPTTNAAGLATQGVAV
Rv1802|M.tuberculosis_H37Rv ARYAEMWAQDAAAMYG-YAGSSSVATQVTPFAAPPPTTNAAGLATQGVAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
: * .:* * *::* . .. . .
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGGQ-AILDFLKDP
TH_3569|M.thermoresistible__bu ATTQQIGSQATAADSGTALNLSDLIANLLQYYQDYLDQLFGPIVDFLRDP
Mflv_0325|M.gilvum_PYR-GCK ADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDP
Mvan_0415|M.vanbaalenii_PYR-1 ADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDP
MAB_0047|M.abscessus_ATCC_1997 ADMMSMAAQPQAAESGSALDSSNNIMDQL--------------MRFMTNP
MMAR_2685|M.marinum_M GQAAAASPAATVQDLLATGPISWLLQLG-----ADLSTGYTAAVTALLNG
MUL_3071|M.ulcerans_Agy99 GQAAAASPAATVQDLLATGPISWLLQLG-----ADLSTGYTAAVTALLNG
MAV_2909|M.avium_104 S-SAASTPAANVAQTAASAASTTLPYSGPFSGPANLAYLYQTFMTNLFN-
Mb1830|M.bovis_AF2122/97 AQAVGAS--AGNARSLVSEVLEFLATAG-----TNYNKTVASLMNAVTG-
Rv1802|M.tuberculosis_H37Rv AQAVGAS--AGNARSLVSEVLEFLATAG-----TNYNKTVASLMNAVTG-
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEG----------MEATVVPQVDQQ
. :
MSMEG_0619|M.smegmatis_MC2_155 -LGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFAS
TH_3569|M.thermoresistible__bu -IGNLFQLIDDFLTNPAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILAS
Mflv_0325|M.gilvum_PYR-GCK -IGNTFALITDFLTNPVQALITWGPFLLAVVYQAVSWVGASILYPSLFLL
Mvan_0415|M.vanbaalenii_PYR-1 -LGNTIKLITDFLTNPAQALITWGPFLAAVAYQAVSWVGASILYPSLLLL
MAB_0047|M.abscessus_ATCC_1997 -LGTLQDMIEDFMRNPVAAFFAWFPLLFFIAYEAFFIPFGFTFWGVLLSA
MMAR_2685|M.marinum_M LFGPSGATTYLTLYNAIKTPLNFTTGFNDIGLLINFPASQFLKFAPHPG-
MUL_3071|M.ulcerans_Agy99 LFGPSGATTYLTLYNAIKTPLNFTTGFNDIGLLINFPASQLLKFAPHPG-
MAV_2909|M.avium_104 -TVPGGASFYTSMYNAVKVPLGLTTQFNGVGLLVNFPLSQWLKFAPPIG-
Mb1830|M.bovis_AF2122/97 --VPYASSVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTP
Rv1802|M.tuberculosis_H37Rv --VPYASSVYNSMLGLGFAESKMVLPANDTVISTIFGMVQFQKFFNPVTP
MLBr_01182|M.leprae_Br4923 VNVDVATPQTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAGMANA
. .
MSMEG_0619|M.smegmatis_MC2_155 PFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLA
TH_3569|M.thermoresistible__bu PVLIPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP-------
Mflv_0325|M.gilvum_PYR-GCK PLLATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFP
Mvan_0415|M.vanbaalenii_PYR-1 PLVATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPA
MAB_0047|M.abscessus_ATCC_1997 PAWLPIVLGLALSALVPPAGIEEPGQEDEPGREPTRIE-RRSPQQDLQLA
MMAR_2685|M.marinum_M --LGPLPKDALGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRGTLVGKLTV
MUL_3071|M.ulcerans_Agy99 --LGPLPKDALGGGLGLAPHWNQGTLFSAIQPEAMTPHWGRGTLVGKLTV
MAV_2909|M.avium_104 --YGALPKDALGAGLG-ALGFGRGTLYSAISPVAGMGNAG--TLVGKLSI
Mb1830|M.bovis_AF2122/97 FNPDLIPKSALGAGLGLRSAISSGLGSTAPAISAGASQAG---SVGGMSV
Rv1802|M.tuberculosis_H37Rv FNPDLIPKSALGAGLGLRSAISSGLGSTAPAISAGASQAG---SVGGMSV
MLBr_01182|M.leprae_Br4923 GLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHV
.
MSMEG_0619|M.smegmatis_MC2_155 VGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEG
TH_3569|M.thermoresistible__bu ------------VRAEPQNPLPLTXXX-----------------------
Mflv_0325|M.gilvum_PYR-GCK ATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEG
Mvan_0415|M.vanbaalenii_PYR-1 IAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTG
MAB_0047|M.abscessus_ATCC_1997 HVPSGSPTPGGSTTTTVTSGGSAPPAP-APATATPAYMVYAVQEDPPAAR
MMAR_2685|M.marinum_M PPSWAAATPTIRTVAAALSAAGPEAVPAAALGEGGLLSSMAVAG-MLGSA
MUL_3071|M.ulcerans_Agy99 PPSWAAATPTIRTVAAALSAAGPEAVPAAALGEGGLLSSMAVAG-MLGSA
MAV_2909|M.avium_104 PPSWATATPSIRTVAAALSAAGAEAVPAAALGEGSLFSSMGLAG-MLGSA
Mb1830|M.bovis_AF2122/97 PPSWAAATPAIRTVAAVFSSTGLQAVPAAAISEGSLLSQMALAS-VAGGA
Rv1802|M.tuberculosis_H37Rv PPSWAAATPAIRTVAAVFSSTGLQAVPAAAISEGSLLSQMALAS-VAGGA
MLBr_01182|M.leprae_Br4923 TAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVATES-ESAPL
.
MSMEG_0619|M.smegmatis_MC2_155 FTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYAD
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK FSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYAD
Mvan_0415|M.vanbaalenii_PYR-1 FSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYAD
MAB_0047|M.abscessus_ATCC_1997 FGPTLNEGSGAKAPAAGISAAAA-AAASARSRARRKRAARIKDPAPQFMD
MMAR_2685|M.marinum_M FGAGAPDAYKRAGVRSRLTPLKD-LKDATSPEKLKRLVAQISEKPESVQH
MUL_3071|M.ulcerans_Agy99 FGAGAPDAYKRAGVRSRLTPLKD-LKDATSPEKLKRLVAQISEKPESVQH
MAV_2909|M.avium_104 VGSGGP-TMVRGGVRNRMTAIKD-LKDKQSPEQLKRLVAQISEQPESVQH
Mb1830|M.bovis_AF2122/97 LGGAAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMMEKPESVQH
Rv1802|M.tuberculosis_H37Rv LGGAAARATGGFLGGGRVTAVKKSLKDSDSPDKLRRVVAHMMEKPESVQH
MLBr_01182|M.leprae_Br4923 LGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG---------
MSMEG_0619|M.smegmatis_MC2_155 AYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VTAAGLT
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQAGGLT
Mvan_0415|M.vanbaalenii_PYR-1 AYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQAGGLT
MAB_0047|M.abscessus_ATCC_1997 MNSSVAPDFSES-AARQTTGVGASARGAGRLGFAGTAPAAAGTTAAAGLV
MMAR_2685|M.marinum_M HTVDQEGLDSLLEQLAKKPGIHAVHLSKGDKAKVVPTDAQPG--------
MUL_3071|M.ulcerans_Agy99 HTVDQEGLDSLLEQLAKKPGIHAVHLSKGDKAKVVPTDAQPG--------
MAV_2909|M.avium_104 HNVDQENLDTLLEQLAKKPGIHAVHLKKGDKSKVLPADAQLG--------
Mb1830|M.bovis_AF2122/97 WHTDEDGLDDLLAELKKKPGIHAVHMAGGNKAEIAPTISESG--------
Rv1802|M.tuberculosis_H37Rv WHTDEDGLDDLLAELKKKPGIHAVHMAGGNKAEIAPTISESG--------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 ---TLTGDTFDDRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3569|M.thermoresistible__bu ------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK ---TLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---TLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MAB_0047|M.abscessus_ATCC_1997 ERDSGTAEALDGARTVPMLPTSWGTDSEHGPDRPAEGGSST-------
MMAR_2685|M.marinum_M ------------------------------------------------
MUL_3071|M.ulcerans_Agy99 ------------------------------------------------
MAV_2909|M.avium_104 ------------------------------------------------
Mb1830|M.bovis_AF2122/97 ------------------------------------------------
Rv1802|M.tuberculosis_H37Rv ------------------------------------------------
MLBr_01182|M.leprae_Br4923 ------------------------------------------------