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MDSTPDELITALRKTLKENERLKRENRDHLAQATEPVAVVGMGCRYPGGIETPEGLWEMVAAGRDVVSDF PTDRGWDGASLFDPDPDAVGKSYTRSGGFLTDVAGFDAEFFGIAPSEVMAMDPQQRLLLEVSWEALERTG IDPTTLRGSATGVFVGVFHGSYGGQGRVPGDLERYGLRGSTLSVASGRVAYVLGLEGPAVSVDTACSSSL VALHLAVQSLRSRECDLALVGGVTVMATPAMFIEFSRQRALSADGRCKAYAGAADGTAFSEGAGALVLER LTDAQRLGHPVLAVVRGSAVNQDGASNGLATPNGPSQQRVIRAALASARLGVADVDVVEGHGTGTTLGDP IEAQAILATYGQDRTGPGKEPLWLGSIKSNMGHTSAAAGVAGVIKMTLAMQHGVLPQTLHVDVPTPHVDW SAGSVSLLTEARPWPETGRARRAGISSFGISGTNAHVILEQAPAAEEVAAQHRTDLTPWILAARSAPALV NQARRLAQWVSDRPDLDVADVGWSLATTRSVFEHRAVVVGADRTQLIQGLAGFVDGEPRAGVVVGRARPV GKTVFVFPGQGSQWVGMGVDLLDTSTVFADQMHRCEKALAEYVSWSLLDVVRAVPGAPGLNRVDVVQPVL WAIMVSLAELWRSAGVLPDAVIGHSQGEIAAAYVAGALSLEDAARVVARRSQLLVQLSGAGGMVSLACGL ERARQLVASWSDRLSIAAVNGVSAIVVSGEVDALDALIGRCEADDIRARRIDVDYASHSAQVEAIRAELA EALDGIAPQSTSTAFISTVTGEFTDTAGLDADYWHRSIRQTVQFERAIRTAFNSGCQVFIESSPHPVLMA GIEETLAGQQDSGEAIVIPSLGRDDGGLQRFWLSVAQAHVAGVRVDWASIIGAGRRVALPTYGFQHRRFW LGQLDAGRTDVGGLGQAGAAHGLLGAVVERPDSGGVVLTGQLSVALQPWLAGHAVAGTVLFPGAGFVELA IRAGDEVGCAAVEELTLSAPLVLPTVGGVQLQVVVGPADQSDHRTVEVYSRGDQSLSEWSLHAEGVLAPA AVASVGQLTAWPPEGATALDLGGVYDRLAARGYEYGPAFRGLQAVWESGDEIFAEVALPEDAGAQIGGFG IHPALLDAALHALVLTAEQNQTVLPFAWQGVSLHAAGASRCRVRIAQSRSGSVAMELADSAGLPVLTVRD LAFRPVSDQTSSAGTAGGGGLLEVVWSPLARPGDDTADIPVTLWDLASQVELSAGAVESTYVATHGALGA LQSWLASDQPGVLAVVTHGAVGLADEDVTDLAGSAVWGLVRSAQAEHPGRVVLVDTDGSVELGAVLNSGE PQLVVRAGVAYQARLKPAESLLRLPPPGENWRLVTGGGGTLDDVKVGGCAPSGLMTGQLRVAVAAVGVNF RDVLVALGMYPGGGELGVEGAGIVTEVGPGVSGVAVGDAVMGLLGVVGPEAVVDHRLVTAVPPGWSLQTA ASVPVVFLTAFYGLRVLAEVRSGQKLLVHAATGGVGMAAVQLARLWGLEVFATASPGKWDTLRAMGFDDD HIANSRTLEFEEKFRAGTGGVGVDAVLNSLAGEFVDASLRLLVPGGRFIEMGKTDLRDPQTMAEQHRGVG YRAFDLIEAGPDLIARMLAELSRLLCAETLTPLPIKTFDVRLARQAYRFVSQARHIGKVVLTLPDETGAV PAGALAGGTVIITGGTGMAGTALARHVVSRHRVANVILVSRSGAQAEGTSELLGQLQDAGAEAAVVACDV SDRDAVAELLAQVPARYPLRGVIHAAGVLDDGLIASLTPQRVDTVLRAKIDGAWNLHELTRGLNLSAFVL FSSMAGIIGTAGQGNYAAANSFLDGLAVHRRALGLPGVSVAWGLWEQASAMTRHLGERDKARMSRVGLAT LSTEHALELFDAAVVADRAVVVATRLDANALKSNSAALPPLLGELAARPKRRVISDADAGDNIAAATGLV ARLHGLSAEQRQRELVDVVCSNAATVLGRSSTADINAHRAFQELGFDSLTAVELRNRLKTATGLTLSPTL IFDYPSPAALAEHLGIRLATATAQPDLMRRFDDLARELDKLINRPDWTHEDKGKLSGRLHDILADLSADD DITTASESQLFAILDEELGS
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2471 | pks7 | - | 100% (2120) | polyketide synthase Pks7 |
M. marinum M | MMAR_2472 | pks8 | 0.0 | 62.34% (2135) | polyketide synthase, Pks8 |
M. marinum M | MMAR_0102 | - | 0.0 | 61.06% (2098) | polyketide synthase PKS |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1689 | pks7 | 0.0 | 70.49% (2138) | polyketide synthase pks7 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 36.55% (2137) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 70.49% (2138) | polyketide synthase pks7 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 55.70% (2088) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 36.16% (2146) | polyketide synthase |
M. avium 104 | MAV_3109 | - | 0.0 | 70.80% (2137) | RifB protein |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 36.81% (2135) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 34.86% (1859) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 59.83% (2066) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_0269 | - | 0.0 | 36.59% (2121) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAB_0939|M.abscessus_ATCC_1997 ------------------------------MDSAENPIESTPRFAIIGYA Mvan_0269|M.vanbaalenii_PYR-1 ------------------------------MGSAEHPNGPAPRFAIVGYA Mflv_0405|M.gilvum_PYR-GCK ------------------------------MGSAAHQGESAHRFAIVGYA MSMEG_0408|M.smegmatis_MC2_155 ------------------------------MVSAEHPIEPTPSFAIIGYA Mb1689|M.bovis_AF2122/97 -------MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMG Rv1661|M.tuberculosis_H37Rv -------MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMG MMAR_2471|M.marinum_M -------MDSTPDELITALRKTLKENERLKRENRDHLAQATEPVAVVGMG MAV_3109|M.avium_104 -------MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMG MUL_2266|M.ulcerans_Agy99 -------MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMS MLBr_00135|M.leprae_Br4923 MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIG TH_4621|M.thermoresistible__bu --------------------------------VNIVGDTPVNAVAVIGMA . .*::* . MAB_0939|M.abscessus_ATCC_1997 ARFPG-AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVV Mvan_0269|M.vanbaalenii_PYR-1 ARFPG-APDADAFWDVLREGRDAISDVPRDR-WDAEEFFDPEPGAPGKVV Mflv_0405|M.gilvum_PYR-GCK GRFPG-ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVV MSMEG_0408|M.smegmatis_MC2_155 ARFPG-AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVV Mb1689|M.bovis_AF2122/97 CRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSY Rv1661|M.tuberculosis_H37Rv CRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSY MMAR_2471|M.marinum_M CRYPGGIETPEGLWEMVAAGRDVVSDFPTDRGWDGASLFDPDPDAVGKSY MAV_3109|M.avium_104 CRYPGGVDSPEALWEMVVEGRDVVSEFPADRGWDLAGLFDADPDAVGKSY MUL_2266|M.ulcerans_Agy99 CRFPGGVDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSY MLBr_00135|M.leprae_Br4923 CRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY TH_4621|M.thermoresistible__bu CRLPGGIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVPGRTV * ** .: * : : :::.* ** ** **.:*.. : MAB_0939|M.abscessus_ATCC_1997 TRRAGFVEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAP Mvan_0269|M.vanbaalenii_PYR-1 TRRAGFVDDVTGFDAPFFGMSTREVRMMDPQHRLLLETAWRAVEHSGTAP Mflv_0405|M.gilvum_PYR-GCK TRRAGFVDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAP MSMEG_0408|M.smegmatis_MC2_155 TRRAGFVDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAP Mb1689|M.bovis_AF2122/97 TRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP Rv1661|M.tuberculosis_H37Rv TRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP MMAR_2471|M.marinum_M TRSGGFLTDVAGFDAEFFGIAPSEVMAMDPQQRLLLEVSWEALERTGIDP MAV_3109|M.avium_104 CRCGGFLTGVGDFDAAFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP MUL_2266|M.ulcerans_Agy99 ASTGGFVDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDP MLBr_00135|M.leprae_Br4923 TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDP TH_4621|M.thermoresistible__bu SRWGAFLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTP ..*: .. .**. ***:: *. :***:*:::* :*.*:* :* * MAB_0939|M.abscessus_ATCC_1997 TDLAETNSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRIS Mvan_0269|M.vanbaalenii_PYR-1 TALAGSNTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRIS Mflv_0405|M.gilvum_PYR-GCK SELANTNTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRIS MSMEG_0408|M.smegmatis_MC2_155 TSLANSNTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRIS Mb1689|M.bovis_AF2122/97 ITLRGSQTGVFAGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA Rv1661|M.tuberculosis_H37Rv ITLRGSQTGVFAGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA MMAR_2471|M.marinum_M TTLRGSATGVFVGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA MAV_3109|M.avium_104 ATLRGSATGVFAGIFHGSYGGQG---RVPGNLERYGLRGSTLSVASGRVA MUL_2266|M.ulcerans_Agy99 TGLRGSATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVA MLBr_00135|M.leprae_Br4923 LSLRGSATGVFTGIFAPSYGS-----RDTGGLQGYGLTGTAVSVASGRVS TH_4621|M.thermoresistible__bu ADVEGSSTGVFVGLSHDDYALLTS--DAGALEEAYGFTGSAFSMASGRIA : : :***.*: .* : * * : : *:**:: MAB_0939|M.abscessus_ATCC_1997 YRLGLQGPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPA Mvan_0269|M.vanbaalenii_PYR-1 YRLGLQGPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVLLTPA Mflv_0405|M.gilvum_PYR-GCK YRLGLQGPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPA MSMEG_0408|M.smegmatis_MC2_155 YRLGLQGPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPA Mb1689|M.bovis_AF2122/97 YVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Rv1661|M.tuberculosis_H37Rv YVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA MMAR_2471|M.marinum_M YVLGLEGPAVSVDTACSSSLVALHLAVQSLRSRECDLALVGGVTVMATPA MAV_3109|M.avium_104 YALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA MUL_2266|M.ulcerans_Agy99 YVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPT MLBr_00135|M.leprae_Br4923 YVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPS TH_4621|M.thermoresistible__bu YRLGVHGPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPR * **:.**:*:*********:*:* * :*: *.****.**. * * MAB_0939|M.abscessus_ATCC_1997 TMITFSHAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDR Mvan_0269|M.vanbaalenii_PYR-1 TMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDR Mflv_0405|M.gilvum_PYR-GCK TMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDR MSMEG_0408|M.smegmatis_MC2_155 TMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDR Mb1689|M.bovis_AF2122/97 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHP Rv1661|M.tuberculosis_H37Rv MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHP MMAR_2471|M.marinum_M MFIEFSRQRALSADGRCKAYAGAADGTAFSEGAGALVLERLTDAQRLGHP MAV_3109|M.avium_104 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHS MUL_2266|M.ulcerans_Agy99 VFVEFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHP MLBr_00135|M.leprae_Br4923 IFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHT TH_4621|M.thermoresistible__bu KYTSASGLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDR * *:. *:.::: **** .** ::: ** ** * .. MAB_0939|M.abscessus_ATCC_1997 IRAVIRGSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEA Mvan_0269|M.vanbaalenii_PYR-1 IRAVIRGSSINQDGASGGLTVPNGVAQQRVIADALKRSDLEPKDVGYLEA Mflv_0405|M.gilvum_PYR-GCK IRAVIRGSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEA MSMEG_0408|M.smegmatis_MC2_155 IRAVIRGSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEA Mb1689|M.bovis_AF2122/97 VLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG Rv1661|M.tuberculosis_H37Rv VLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG MMAR_2471|M.marinum_M VLAVVRGSAVNQDGASNGLATPNGPSQQRVIRAALASARLGVADVDVVEG MAV_3109|M.avium_104 VLAVLRGSAVNQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEG MUL_2266|M.ulcerans_Agy99 VLALVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEG MLBr_00135|M.leprae_Br4923 VLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEA TH_4621|M.thermoresistible__bu ILAVVRGTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEA : *::**:: **** : .::.*. :* * ** : : *. :*. MAB_0939|M.abscessus_ATCC_1997 HGTGTSLGDPIEAQAAGAAYGIG----RETNDPLLIGSAKTNIGHLEAAA Mvan_0269|M.vanbaalenii_PYR-1 HGTGTSLGDPIEAQAAGAVLGAG----REPSRPLLIGSAKTNIGHLEAAA Mflv_0405|M.gilvum_PYR-GCK HGTGTSLGDPIEAQAAGAALGPG----REPQRPLLIGSAKTNIGHLEAAA MSMEG_0408|M.smegmatis_MC2_155 HGTGTSLGDPIEAQAAGEVLGAG----RAPEEPLLIGSAKTNIGHLEAAA Mb1689|M.bovis_AF2122/97 HGTGTTLGDPIEAQAILATYGQ-----RPADRPLWLGSIKSNIGHTSAAA Rv1661|M.tuberculosis_H37Rv HGTGTTLGDPIEAQAILATYGQ-----RPADRPLWLGSIKSNIGHTSAAA MMAR_2471|M.marinum_M HGTGTTLGDPIEAQAILATYGQDR--TGPGKEPLWLGSIKSNMGHTSAAA MAV_3109|M.avium_104 HGTGTMLGDPIEAQALLATYGQD----RPVDEPLWLGSIKSNMGHTSAAA MUL_2266|M.ulcerans_Agy99 HGTGTTLGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAA MLBr_00135|M.leprae_Br4923 HGTATTLGDPIEAQALLATYGQG----RPADQPLWVGSIKSNMGHTQAAA TH_4621|M.thermoresistible__bu HGTGTPVGDPIEYNSLTQVYGKTG--------PCALTSVKTNFGHAESAA ***.* :***** :: . * . : * *:*:** .:** MAB_0939|M.abscessus_ATCC_1997 GIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGRN- Mvan_0269|M.vanbaalenii_PYR-1 GIAGVIKVILSLEHRTLPKHLNFENPSPHIPWDRLAVEVVKETIPWERD- Mflv_0405|M.gilvum_PYR-GCK GIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQ MSMEG_0408|M.smegmatis_MC2_155 GIAGVIKVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQRN- Mb1689|M.bovis_AF2122/97 GVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP- Rv1661|M.tuberculosis_H37Rv GVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP- MMAR_2471|M.marinum_M GVAGVIKMTLAMQHGVLPQTLHVDVPTPHVDWSAGSVSLLTEARPWPET- MAV_3109|M.avium_104 GAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSAGAVSLLTEARPWPAR- MUL_2266|M.ulcerans_Agy99 GVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAES MLBr_00135|M.leprae_Br4923 GVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVE- TH_4621|M.thermoresistible__bu GALGMMKAILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVR- * *::* ::.: :* :. . .: : : . * MAB_0939|M.abscessus_ATCC_1997 --GRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILP Mvan_0269|M.vanbaalenii_PYR-1 --GGPRIAGVSSFGFAGTNAHVILEEAP--EQAAAPGPVQQPDRRFSLLP Mflv_0405|M.gilvum_PYR-GCK RGGRPRIAGVSSFGFAGTNAHVILEEAP---LAAEPAQESVDDGRFTLLP MSMEG_0408|M.smegmatis_MC2_155 --GKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATTEPVE-DPRRYSVLP Mb1689|M.bovis_AF2122/97 --GRPRRAGVSSFGISGTNAHVILEEAP-AVEPVGAAHGNDP--VAVPWV Rv1661|M.tuberculosis_H37Rv --GRPRRAGVSSFGISGTNAHVILEEAP-AVEPVGAAHGNDP--VAVPWV MMAR_2471|M.marinum_M --GRARRAGISSFGISGTNAHVILEQAP-AAEEVAAQHRTD----LTPWI MAV_3109|M.avium_104 --DRPRRAGVSSFGISGTNAHVIVEQY----EPETVAPQGGD--VVVPWV MUL_2266|M.ulcerans_Agy99 AGDRVRRAGVSSFGISGTNAHVIVEAAP-RVEVGGSS-GGAV--PVVPWV MLBr_00135|M.leprae_Br4923 --GRPRRAGVSSFGISGTNAHVILEEAP-TPVEASYSTADQQRLSVVPWV TH_4621|M.thermoresistible__bu -EGCPRRAAVSSYGMSGTNVHAVLEQAP-EPVQRPEESADTDAAGPLVFA . * *.:**:*::***.*.::* MAB_0939|M.abscessus_ATCC_1997 LSARTPAALAQLADKYRAWLNAH-PEAALADLCFTAGVGRAHLEHRAALV Mvan_0269|M.vanbaalenii_PYR-1 LSARTPAALTQLAGQYRDWWTAH-PEATLADVCFTAGAGRAHLEHRAALV Mflv_0405|M.gilvum_PYR-GCK LSARTPAALMAVADRYRDWLVAN-PDATLADLCFTAGTARSHLEHRAALV MSMEG_0408|M.smegmatis_MC2_155 LSARTPEALVRLAGEYRDWLRAH-PQARLADVSHTAGTARAHLEQRAALV Mb1689|M.bovis_AF2122/97 LSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSLFDHRAVVV Rv1661|M.tuberculosis_H37Rv LSARSAQALTNQARRLLAWVGAD-ENVRPLDVGWSLVNTRSLFDHRAVVV MMAR_2471|M.marinum_M LAARSAPALVNQARRLAQWVSDR-PDLDVADVGWSLATTRSVFEHRAVVV MAV_3109|M.avium_104 LSARSAEALTNQAARLLARVKAD-PGVRVLDVGWSLVSTRSRFEHRAVIV MUL_2266|M.ulcerans_Agy99 VSAKSGSALGAQAARLAAHVRSH-DELDVADVGWSLAG-RSTFEHRAVVL MLBr_00135|M.leprae_Br4923 VSGRSTAALMAQASRLAFYVQAD-PEVDPVDVGCALAA-RSVFEHRAVVV TH_4621|M.thermoresistible__bu LSSTSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVI ::. : * * . *: : *: *:.:: MAB_0939|M.abscessus_ATCC_1997 VNTREAAVELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGSQYPGMA Mvan_0269|M.vanbaalenii_PYR-1 VNSAESAVELLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMA Mflv_0405|M.gilvum_PYR-GCK VNTREAALDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMS MSMEG_0408|M.smegmatis_MC2_155 VNSRESAIELLGALADDRPA-PGLVRGESHEAPKTAWLFTGQGSQYPGMA Mb1689|M.bovis_AF2122/97 GADRTQLMEGLTGLAAGVPG-ADVVAGRAQTVGKTAFVFPGQGAQWLGMG Rv1661|M.tuberculosis_H37Rv GADRTQLMEGLTGLAAGVPG-ADVVAGRAQTVGKTAFVFPGQGAQWLGMG MMAR_2471|M.marinum_M GADRTQLIQGLAGFVDGEPR-AGVVVGRARPVGKTVFVFPGQGSQWVGMG MAV_3109|M.avium_104 GADGAQLLRRLADLAGGQPG-AGVVTGRAQPVGKTVFVFPGQGSQWPGMG MUL_2266|M.ulcerans_Agy99 GADRDGLLAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMG MLBr_00135|M.leprae_Br4923 GESREQLIAGLAGLAVGESG-AGVAIGQAAPLGKTVVVFPGQGAQRIGMG TH_4621|M.thermoresistible__bu ADGVEALTAGLREVADGDAP---YQPAVGMDDKAPVWVFSGQGSQWAGMG * .. . . . .. :*.***:* **. MAB_0939|M.abscessus_ATCC_1997 RELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQ Mvan_0269|M.vanbaalenii_PYR-1 RELYDTEPVFAETLNRCAEAVADVLEKPLLDVIFDAE---ADDAEKTLQN Mflv_0405|M.gilvum_PYR-GCK RELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRH MSMEG_0408|M.smegmatis_MC2_155 RELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRH Mb1689|M.bovis_AF2122/97 AQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAP------GAPGLDR Rv1661|M.tuberculosis_H37Rv AQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAP------GAPGLDR MMAR_2471|M.marinum_M VDLLDTSTVFADQMHRCEKALAEYVSWSLLDVVRAVP------GAPGLNR MAV_3109|M.avium_104 AQLLDRSTVFAEHMHRCARALAEHVDWSLIDVIRGAP------GAPGLDR MUL_2266|M.ulcerans_Agy99 IELLDTAPVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDR MLBr_00135|M.leprae_Br4923 RELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD------AG-LLDS TH_4621|M.thermoresistible__bu AELLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET---------VTG :* :** . . .: :.: : MAB_0939|M.abscessus_ATCC_1997 TSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLED Mvan_0269|M.vanbaalenii_PYR-1 TCYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAGVFSLTD Mflv_0405|M.gilvum_PYR-GCK TSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRD MSMEG_0408|M.smegmatis_MC2_155 TTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVED Mb1689|M.bovis_AF2122/97 VDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLWD Rv1661|M.tuberculosis_H37Rv VDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAGALSLRD MMAR_2471|M.marinum_M VDVVQPVLWAIMVSLAELWRSAGVLPDAVIGHSQGEIAAAYVAGALSLED MAV_3109|M.avium_104 VDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAACVAGALSLHD MUL_2266|M.ulcerans_Agy99 IDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRD MLBr_00135|M.leprae_Br4923 TEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPAD TH_4621|M.thermoresistible__bu IDRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLED .**.*:*: :.* : *. *. *:*** *: :** ** .: * MAB_0939|M.abscessus_ATCC_1997 GARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFPS--LSVAAYNG Mvan_0269|M.vanbaalenii_PYR-1 GARLMAERGRLFGSLPEGGRMVAVFTTAERAEAMTDEFPS--LSVAAYNG Mflv_0405|M.gilvum_PYR-GCK GARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEYPA--LSVAAYNG MSMEG_0408|M.smegmatis_MC2_155 GARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYPS--LSVAAYNG Mb1689|M.bovis_AF2122/97 AAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDR-LNIAAVNG Rv1661|M.tuberculosis_H37Rv AAAVVALRSRLLVRLGGAGGMVSLACGQPQAEKLASQWGDR-LNIAAVNG MMAR_2471|M.marinum_M AARVVARRSQLLVQLSGAGGMVSLACGLERARQLVASWSDR-LSIAAVNG MAV_3109|M.avium_104 AARVVALRSRLLVRLSGRGGMVSLACGRSRAEQLIAPWGER-LNIATVNG MUL_2266|M.ulcerans_Agy99 AAKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDR-VSIAAING MLBr_00135|M.leprae_Br4923 AAMLVVARGRLMQSMPAGGTMWAVAASE---DEVVSLLGEG-VGIAAINA TH_4621|M.thermoresistible__bu GVKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIAS .. :: *.:* : * * :: . : ::. . MAB_0939|M.abscessus_ATCC_1997 -ANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEA Mvan_0269|M.vanbaalenii_PYR-1 -TNTVLSGPAGDLEKAVATLSADGVRCDWLDTSHAFHSALLDPILDDFES Mflv_0405|M.gilvum_PYR-GCK -ANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFES MSMEG_0408|M.smegmatis_MC2_155 -ANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFES Mb1689|M.bovis_AF2122/97 VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIA Rv1661|M.tuberculosis_H37Rv VSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAIREELIA MMAR_2471|M.marinum_M VSAIVVSGEVDALDALIGRCEADDIRARRIDVDYASHSAQVEAIRAELAE MAV_3109|M.avium_104 ISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAE MUL_2266|M.ulcerans_Agy99 PSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTE MLBr_00135|M.leprae_Br4923 PESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVR TH_4621|M.thermoresistible__bu PESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEE *:.* : : .. * ** :: : .: MAB_0939|M.abscessus_ATCC_1997 YANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRT Mvan_0269|M.vanbaalenii_PYR-1 YANQFDFAAPQRILIDNRTGTALGRSVQLDGTYWRRHARQPVEFAKSVRT Mflv_0405|M.gilvum_PYR-GCK YARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHT MSMEG_0408|M.smegmatis_MC2_155 FAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRT Mb1689|M.bovis_AF2122/97 ALRGIEPRTSTVAFFSTVTG-ELMDTAGVNAEYWYRSIRQPVQFERAVRN Rv1661|M.tuberculosis_H37Rv ALRGIEPRTSTVAFFSTVTG-ELMDTAGVNAEYWYRSIRQPVQFERAVRN MMAR_2471|M.marinum_M ALDGIAPQSTSTAFISTVTG-EFTDTAGLDADYWHRSIRQTVQFERAIRT MAV_3109|M.avium_104 ALRGIAPRSSAVAFFSTVTG-ELMDTAALDGDYWFRSIRQTVQFERAVRG MUL_2266|M.ulcerans_Agy99 VLAGIEPLSSRTAFFSSVTG-SRLDTAELDAEYWYRNIRQTVQFDQAVRS MLBr_00135|M.leprae_Br4923 VAAQVEVRKPQIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRFVDSARH TH_4621|M.thermoresistible__bu ILADLQPMTPTVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRFAAAVQA . . . *. . ** : *.* : : MAB_0939|M.abscessus_ATCC_1997 LADMNCKVLLEIGPQPVLTAAALRAWPDP----ATAPRAIASLRRNTADH Mvan_0269|M.vanbaalenii_PYR-1 LAEMNCKLLVEIGPRPVLTAAALGAWPDP----ATAPRVIASLRRTAADH Mflv_0405|M.gilvum_PYR-GCK LADMNCKLLVEIGPRPVLTAAALSAWPDP----ATSPRVIASLRRTTADQ MSMEG_0408|M.smegmatis_MC2_155 LADMNCRVLLEIGPRPVLTATALAAWPDP----ATTPQVLASLRPTTADH Mb1689|M.bovis_AF2122/97 AFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGV Rv1661|M.tuberculosis_H37Rv AFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLGRDDGGV MMAR_2471|M.marinum_M AFNSGCQVFIESSPHPVLMAGIEETLAGQQD--SGEAIVIPSLGRDDGGL MAV_3109|M.avium_104 AAEAGYRAFIECSPHPVLTAAIEETMP-----DGGQGCVIPSLGRDDGGP MUL_2266|M.ulcerans_Agy99 ACGHGYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGL MLBr_00135|M.leprae_Br4923 LQTLGATHFIESGPSSGLMGAIEQSLAP------AEAVVVSMMGKDRPEL TH_4621|M.thermoresistible__bu ALEDGFRVFGELSPHPLLTRAVEQTARG----LDMPVAALPAMRREQEMP . : * .* . * : .:. : MAB_0939|M.abscessus_ATCC_1997 RQITEAAADAYVLGHLPDFGAFQHA-PARKLDLPTYPFERRQYWFSDKRD Mvan_0269|M.vanbaalenii_PYR-1 RQITEAVADAYVLGHLPEFGAFRDA-GARKLDLPTYPFEHRQYWFRDNQD Mflv_0405|M.gilvum_PYR-GCK RQITEAVADAYVLGHLPRFAAFRRD-GARVLDLPTYPFEHRQYWFSDSRE MSMEG_0408|M.smegmatis_MC2_155 RQITEAVAAAYAAGHLPDFRAFRQP-DARKLDLPTYPFEHRQFWFSDNRA Mb1689|M.bovis_AF2122/97 GRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGA Rv1661|M.tuberculosis_H37Rv GRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFWLDGLGA MMAR_2471|M.marinum_M QRFWLSVAQAHVAGVRVDWASIIG--AGRRVALPTYGFQHRRFWLGQLDA MAV_3109|M.avium_104 DRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDLPTYGFVRQHFWLPGGST MUL_2266|M.ulcerans_Agy99 QRFLASAAAAFVAGVNVDWRGPLD--GAGLVELPTYAFEKRRFWLSG-EG MLBr_00135|M.leprae_Br4923 ASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTD TH_4621|M.thermoresistible__bu HGVRTMVGDLFAAGAAVDFAALYPS--GRLVDAPLPTWTRRKLVLSRENG . .. .. * : . : * : ::: MAB_0939|M.abscessus_ATCC_1997 GDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLNVLT Mvan_0269|M.vanbaalenii_PYR-1 PD----GSEALQPRTPSTEAVRLLEDGRIEELATLLDGAAGDQQTLDVLS Mflv_0405|M.gilvum_PYR-GCK PV------AAAPQRGARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLN MSMEG_0408|M.smegmatis_MC2_155 IDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLRVLN Mb1689|M.bovis_AF2122/97 VGGDLGGVGLVGAEHGLLAAVVQRPDS---------GGVVLTGRISVVAA Rv1661|M.tuberculosis_H37Rv VGGDLGGVGLVGAEHGLLAAVVQRPDS---------GGVVLTGRISVVAA MMAR_2471|M.marinum_M GRTDVGGLGQAGAAHGLLGAVVERPDS---------GGVVLTGQLSVALQ MAV_3109|M.avium_104 GSSDVAALGLRGAEHGLLGAVLPRPDS---------GGVVLTGRLSTSAQ MUL_2266|M.ulcerans_Agy99 VSVDASGLGLSAGGHALLGAVVELPES---------GGVVLTGRLALGAH MLBr_00135|M.leprae_Br4923 GTASVSGLGLGSTEHALLGAVVERPDS---------GGVVLTGRLSLANQ TH_4621|M.thermoresistible__bu EQQTRG--GCTITVHPLLGTHVRLPEEP--------ERHVWQADLGTGAQ : : MAB_0939|M.abscessus_ATCC_1997 KLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADAAG Mvan_0269|M.vanbaalenii_PYR-1 RLAAQHNQQRSSQSITNDRYEIRWEQSAAALSGAETDEVSSWILVGDDTE Mflv_0405|M.gilvum_PYR-GCK RLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGDDTD MSMEG_0408|M.smegmatis_MC2_155 KLAARHNQQRSTHVDPDARYEIRWDAIAS--AAASTGAAADWILVGDDTA Mb1689|M.bovis_AF2122/97 PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG Rv1661|M.tuberculosis_H37Rv PWLADHAVGPVVLFPGTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG MMAR_2471|M.marinum_M PWLAGHAVAGTVLFPGAGFVELAIRAGDEVGCAAVEELTLSAPLVLPTVG MAV_3109|M.avium_104 AWLADHAVGDTVLFPGAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASG MUL_2266|M.ulcerans_Agy99 GWLADHAVSGVVVFPGTGFVELAIRAVDEVGCSVVNELTLRTPLVLPASG MLBr_00135|M.leprae_Br4923 PWLADHVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGS TH_4621|M.thermoresistible__bu PWLADHQIHTVAALPGAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLD * * :: . MAB_0939|M.abscessus_ATCC_1997 AAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRIVHV Mvan_0269|M.vanbaalenii_PYR-1 ATRPLVDVLSARGQRYRIFGLPVSDADEEQLGEALRLAAAEDSTLRIVHV Mflv_0405|M.gilvum_PYR-GCK ATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATDLRIVHV MSMEG_0408|M.smegmatis_MC2_155 AVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYVVHI Mb1689|M.bovis_AF2122/97 -VRVQVVVGGVEQSGTRNVWVYSAAG---QADSSPGWTLHAQGVLGVGSV Rv1661|M.tuberculosis_H37Rv -VRVQVVVGGVEQSGTRNVWVYSAAG---QADSSPGWTLHAQGVLGVGSV MMAR_2471|M.marinum_M GVQLQVVVGPADQSDHRTVEVYSRGD---QSLS--EWSLHAEGVLAPAAV MAV_3109|M.avium_104 GVRLQLVVGAPDEAGRRPLSVYSAAA---HQDS--EWMLHAEGVLRTGTV MUL_2266|M.ulcerans_Agy99 SVAVQVVVGAAADSAERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSA MLBr_00135|M.leprae_Br4923 GVQVQVVVAAADESSRRAVSVYSRGD-----QSHGGWLLNAEGLLEVDAA TH_4621|M.thermoresistible__bu EQTEVSAVASAVEPGTLEFAVETAKD-----GEHERRATAVLGAADDTEP . . : MAB_0939|M.abscessus_ATCC_1997 AALAGQ----GSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTR Mvan_0269|M.vanbaalenii_PYR-1 GGLDSDPDPGTAPSMRSLLRMQHRILGGTRRLFRAAAAAELRTPIWVVTR Mflv_0405|M.gilvum_PYR-GCK AALDAA---ESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWLVTR MSMEG_0408|M.smegmatis_MC2_155 AAGDGA-----AAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTR Mb1689|M.bovis_AF2122/97 QPAAELSVWPPVGARAMDVADGYQVLAARG----YGYGPAFRGLQALWRR Rv1661|M.tuberculosis_H37Rv QPAAELSVWPPVGARAMDVADGYQVLAARG----YGYGPAFRGLQALWRR MMAR_2471|M.marinum_M ASVGQLTAWPPEGATALDLGGVYDRLAARG----YEYGPAFRGLQAVWES MAV_3109|M.avium_104 TPAGDLSIWPPIGATAVDVTGGYARLAQRG----YEYGRAFRGLRAMWQR MUL_2266|M.ulcerans_Agy99 QPAADLSAWPPAGAIAVDVADGYERLDARG----YGYGPAFRGLTAMWAR MLBr_00135|M.leprae_Br4923 EATVDLSLWPPEGAESVDISDAYPQLAERG----YAYGPAFQGLVAIWRR TH_4621|M.thermoresistible__bu PQAHDIDALLAEHPTRIEGDELRQWFDQRG----VQFGPAFTGLTAARIP . : : MAB_0939|M.abscessus_ATCC_1997 G---AQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDEW Mvan_0269|M.vanbaalenii_PYR-1 R---AQHVTATDTVAPDQSCLWGFGRAAALELPQLWGGLADLADGTADEW Mflv_0405|M.gilvum_PYR-GCK G---AQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDEW MSMEG_0408|M.smegmatis_MC2_155 D---GQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSG-ADTEW Mb1689|M.bovis_AF2122/97 G---AEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEG----EQQ Rv1661|M.tuberculosis_H37Rv G---AEVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEG----EQQ MMAR_2471|M.marinum_M G---DEIFAEVALPEDAGAQIGGFGIHPALLDAALHALVLTAE----QNQ MAV_3109|M.avium_104 G---DEIFAEVALPDD-AAAGDDFGVHPVLLDAALHALGVAGE----KDQ MUL_2266|M.ulcerans_Agy99 G---EELFAEARLPEA-AGSTSGFGVHPALLDAALHTAVIANP----DAD MLBr_00135|M.leprae_Br4923 G---SELFAEVVAPTG--VVVDGMGMHPALLDAVLHALGLAIENTQATTE TH_4621|M.thermoresistible__bu EGTVTSVLAEVGLPGQIRSQQAPYGIHPALLDACFQSVAAHPDVQGAGSG . . * . : . . MAB_0939|M.abscessus_ATCC_1997 AQFIGRVSVSGEA----STREDQLALRGQAVHVPRLVRREELPSGKP-LE Mvan_0269|M.vanbaalenii_PYR-1 SRLLNRITAPHGP----AVREDQIALRDHAVYVPRLVRRAGRPAGKP-LQ Mflv_0405|M.gilvum_PYR-GCK SRLLNRIAATHDP----AVMEDQVAVRGSTSYVPRLVHRDTLPSGKP-LH MSMEG_0408|M.smegmatis_MC2_155 PRLIARITSPRD-------GEDQIALRGDAVYAPRLVRRTGEPSDTP-LP Mb1689|M.bovis_AF2122/97 TMLPFSWQGVCLH----ASGAARVRVRLAPVGRGAVPVELADPQGLPVLS Rv1661|M.tuberculosis_H37Rv TMLPFSWQGVCLH----ASGAARVRVRLAPVGRGAVSVELADPQGLPVLS MMAR_2471|M.marinum_M TVLPFAWQGVSLH----AAGASRCRVRIAQSRSGSVAMELADSAGLPVLT MAV_3109|M.avium_104 TVLPFSWQGVALH----ASGASRARVRIAPAGAGAVSVELADGAGLPVLS MUL_2266|M.ulcerans_Agy99 LVLPFSWQGVSLH----AAGAASVRVRIAPVGPSSVSVELADDLGLPVLS MLBr_00135|M.leprae_Br4923 MRLPFCWRGVSLH----AGGAGRVRARFTSAGADAIAVDIADSAGLPVLT TH_4621|M.thermoresistible__bu LLLPLGVRRLQAFGPTRGARYCYARVTDADGSKAEADLDVLDEHGNVLLR : . * MAB_0939|M.abscessus_ATCC_1997 VRSDATY------------------------------------------L Mvan_0269|M.vanbaalenii_PYR-1 LRDDATY------------------------------------------L Mflv_0405|M.gilvum_PYR-GCK LRADATY------------------------------------------L MSMEG_0408|M.smegmatis_MC2_155 VREDRTY------------------------------------------L Mb1689|M.bovis_AF2122/97 VRQLMVR------------------------------------------P Rv1661|M.tuberculosis_H37Rv VRQLMVR------------------------------------------P MMAR_2471|M.marinum_M VRDLAFR------------------------------------------P MAV_3109|M.avium_104 VRSVTMR------------------------------------------P MUL_2266|M.ulcerans_Agy99 VKAMVAR------------------------------------------P MLBr_00135|M.leprae_Br4923 VRSLVTR------------------------------------------A TH_4621|M.thermoresistible__bu VQGLLMGGAAADGDDRDRVLGERLLTIEWQRRDLPEADSAAGKWLLVSTS :: MAB_0939|M.abscessus_ATCC_1997 VTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQR----------- Mvan_0269|M.vanbaalenii_PYR-1 VTGGLGSIGLEIAGYLAAHGARHLVLTSRRAPGDATQQR----------- Mflv_0405|M.gilvum_PYR-GCK VTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASR----------- MSMEG_0408|M.smegmatis_MC2_155 VTGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRR----------- Mb1689|M.bovis_AF2122/97 VS--AAALSRSTAG---DRGLLEMIWTPVPLEGGDIGDD----------- Rv1661|M.tuberculosis_H37Rv VS--AAALSRSTAG---DRGLLEMIWTPVPLEGGDIGDD----------- MMAR_2471|M.marinum_M VS--DQTSSAGTAG---GGGLLEVVWSPLARPGDDTADIP---------- MAV_3109|M.avium_104 VSPGQLSAAMGTAQ---PSGLLDVIWSPIALGGNDLGDE----------- MUL_2266|M.ulcerans_Agy99 VSEQQMRAVVSASG---PDRLFEVVWTPMTVAATDAAPAY---------- MLBr_00135|M.leprae_Br4923 MTAEQLRTAVTAAGGALEQGPMDLVWSPIPLSSDGHGGGLPSVVSWADYC TH_4621|M.thermoresistible__bu ATADVSATRLSDALKQAGAESTSMCWPQQADHADNVDRFRAGIADG---- : : : . MAB_0939|M.abscessus_ATCC_1997 -------IDALAAQG-CEVRAVTADVADGHDVARLLAGIQAELPPLAGIV Mvan_0269|M.vanbaalenii_PYR-1 -------IDALGAQHSCQIRVVAADVADAHDVARLLAAVAAELPPLAGIV Mflv_0405|M.gilvum_PYR-GCK -------IEALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIV MSMEG_0408|M.smegmatis_MC2_155 -------LDGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIV Mb1689|M.bovis_AF2122/97 --------AVVWELPPHAG-AQAGGDVLAAVYRGVHEVLEVLQSWLASDA Rv1661|M.tuberculosis_H37Rv --------AVVWELPPHAG-AQAGGDVLAAVYRGVHEVLEVLQSWLASDA MMAR_2471|M.marinum_M --------VTLWDLASQVE-LSAG--AVESTYVATHGALGALQSWLASDQ MAV_3109|M.avium_104 --------VTLWEPG------EHGGDVVKSVHAAVTETLAVLQSWLDGEG MUL_2266|M.ulcerans_Agy99 --------ELFESIA-------ADGDPLSGTYQRTHQALAAVQSWLTEHD MLBr_00135|M.leprae_Br4923 AGRGNDTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFGQDR TH_4621|M.thermoresistible__bu ------VTGVVVLTGPKNGNPDDAAARRGSDYVRHLVRITRELAEIDGDA . : : MAB_0939|M.abscessus_ATCC_1997 HAAGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAA-GLK--LDFFIN Mvan_0269|M.vanbaalenii_PYR-1 HAAGEIGTTPLVSLEDSEVDRVFAGKVWGAWHLSEAAA-DLQ--LDFFLG Mflv_0405|M.gilvum_PYR-GCK HAAGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATS-DLQ--LDFFIS MSMEG_0408|M.smegmatis_MC2_155 HAAGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALT-DLRTDLDFFVS Mb1689|M.bovis_AF2122/97 TGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEH-PGRVVLVDTDG Rv1661|M.tuberculosis_H37Rv TGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEH-PGRVVLVDTDG MMAR_2471|M.marinum_M PGVLAVVTHGAVGLADEDVTDLAGSAVWGLVRSAQAEH-PGRVVLVDTDG MAV_3109|M.avium_104 AGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEH-PGRLVLIDSDG MUL_2266|M.ulcerans_Agy99 SGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTEN-PGRLVLVDSDA MLBr_00135|M.leprae_Br4923 AGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEH-SGKIVLIDTDS TH_4621|M.thermoresistible__bu P-RLFVVTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIAD : * : . : * : : : MAB_0939|M.abscessus_ATCC_1997 TSSIAAVWG----GYGQTAYSAANAFLDGLAWRLREQG--IAGTSVNFGP Mvan_0269|M.vanbaalenii_PYR-1 TSSIASVWG----GYGQTAYGAANAFLDGLAWRLREQG--ISGVSINFGP Mflv_0405|M.gilvum_PYR-GCK TSSIASVWG----GFGQAAYGAANAFLDGLAWRLREQG--VAGVSVNFGP MSMEG_0408|M.smegmatis_MC2_155 TSSIASVWG----GFGQTAYGAANAFLDGLAWRLRERG--VTAVSVNFGP Mb1689|M.bovis_AF2122/97 SVAVEDAVGFGA-RSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGG Rv1661|M.tuberculosis_H37Rv SVAVEDAVGFGA-RSGEPQLVVRRGRVYAARLAPVAAG--LTLPSASAGG MMAR_2471|M.marinum_M SVELGAVL-----NSGEPQLVVRAGVAYQARLKPAESL--LRLPPPGEN- MAV_3109|M.avium_104 SLDARAVIP-----CGEPQVVVRQGVAHAARLRPARAG--ATLG-LPSGA MUL_2266|M.ulcerans_Agy99 AVDAAAVAT-AL-AVGEPQVVLRNGQPYTARVHASRAAD-GILVPPVDGP MLBr_00135|M.leprae_Br4923 AVDVAVLAD-----LGESQLLVRCNTVHAARLSPAPQL---LALPVGESM TH_4621|M.thermoresistible__bu DADLDRVAVQLLGGGAEDETAWRDGQWYTARLSLSPLRPEERKQAVVDCE .: MAB_0939|M.abscessus_ATCC_1997 WSAGMADAESRARLEQRGIKTLSPTDALAGLADVVAASGS-NAVQGVIAR Mvan_0269|M.vanbaalenii_PYR-1 WSAGMADAESRARLDQRGVRTLSPADALAGLADVVTAAEAPGPAQGIVAR Mflv_0405|M.gilvum_PYR-GCK WSAGMADAQSRARLEQRGIKTLSPADALAGLSDAVISAAP----HPVVAR MSMEG_0408|M.smegmatis_MC2_155 WAAGMADAESRARLEQRGVRTLSPAEALAGMADVVAGPVQ-----GVVAK Mb1689|M.bovis_AF2122/97 WRLVAGGGGTLADVVVAPVAPV---ELATGQVRVAVGAVG-------VNF Rv1661|M.tuberculosis_H37Rv WRLVAGGGGTLADVVVAPVAPV---ELATGQVRVAVGAVG-------VNF MMAR_2471|M.marinum_M WRLVTGGGGTLDDVKVGGCAPS---GLMTGQLRVAVAAVG-------VNF MAV_3109|M.avium_104 WRLDAGGEGTLGDLVVSRCPRT---ELADGQVRVAVAAVG-------VNF MUL_2266|M.ulcerans_Agy99 WRLGLSSAGTFENLQLEPVPNAG-APLGPGQVRVAMRAIA-------ANF MLBr_00135|M.leprae_Br4923 WRLAADGGGTLEDLVIQPCPEVQ-APLQAGHMRVAVAAVG-------VNF TH_4621|M.thermoresistible__bu RDGMRLEIRTPGDLETMELAAFDRVPPGPGQIEVAVTASS-------INF : : * .. . MAB_0939|M.abscessus_ATCC_1997 IDWARFLPLYQQAGKRGFLAELDREVPSHLAGV--AGAQSGSTQLVERLA Mvan_0269|M.vanbaalenii_PYR-1 IDWERFLPLYQQAGRRAFLAELEREVPDTAP----AATPSGRTELVERLT Mflv_0405|M.gilvum_PYR-GCK VDWSRFLPLYQQAGRRGFLAELERELPAAPAQQGPAVTASGRTPLVERLT MSMEG_0408|M.smegmatis_MC2_155 IDWSRFLPLYQQAGRRAFLSELESELPAAATGAAAPATVPGKPPLVEQLT Mb1689|M.bovis_AF2122/97 RDVLVALGMYPGGGE---------------------LGVDGAGVVVEVGP Rv1661|M.tuberculosis_H37Rv RDVLVALGMYPGGGE---------------------LGVDGAGVVVEVGP MMAR_2471|M.marinum_M RDVLVALGMYPGGGE---------------------LGVEGAGIVTEVGP MAV_3109|M.avium_104 RDVLVALGMYPGGGR---------------------LGAEGAGVVVEVGP MUL_2266|M.ulcerans_Agy99 RDIMITLGMFTHDAL---------------------IGGEGAGVVVEIGP MLBr_00135|M.leprae_Br4923 RDVVAALGMYPGQAPP--------------------LGAEGAGVVIEIGP TH_4621|M.thermoresistible__bu ADVLIAFGRYPTFDGRR-----------------PQLGTDFAGVVTAVGP * : : : . MAB_0939|M.abscessus_ATCC_1997 NAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELR Mvan_0269|M.vanbaalenii_PYR-1 NAPVQQRKKLLTDYLRTAVAEITRVDATEIREDAGFFDLGMDSLMAVELR Mflv_0405|M.gilvum_PYR-GCK TAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELR MSMEG_0408|M.smegmatis_MC2_155 KAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELR Mb1689|M.bovis_AF2122/97 GVTGLAVGDRVMGLLG-LVGSEAVVDARLVTMVP---------------- Rv1661|M.tuberculosis_H37Rv GVTGLAVGDRVMGLLG-LVGSEAVVDARLVTMVP---------------- MMAR_2471|M.marinum_M GVSGVAVGDAVMGLLG-VVGPEAVVDHRLVTAVP---------------- MAV_3109|M.avium_104 AVTGLAVGDPVMGLLG-VVGSEAVVDQRLLTAVP---------------- MUL_2266|M.ulcerans_Agy99 EVTEFAVGDAVYGFFPDGSGTLVAGDVRLLLPKP---------------- MLBr_00135|M.leprae_Br4923 EVTGVAVGDAVMGFLG-GAGPLAVVHQQLITQMP---------------- TH_4621|M.thermoresistible__bu DVTSHRVGDRVGGLSPNGCWSTFVTCDADLAVPLP--------------- .. : . : MAB_0939|M.abscessus_ATCC_1997 RRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVLGLAEQA--KPAAQLAS Mvan_0269|M.vanbaalenii_PYR-1 RRIEQGVGREIPATLAMDHPRLSDVADYLLGEVLGLAEQAPAKAGSQPAS Mflv_0405|M.gilvum_PYR-GCK RRIETGVGKEIPVTLVMDHPRLSDAADYLLGDVLGLTEAA---TAPKAAT MSMEG_0408|M.smegmatis_MC2_155 RRIEQGVGKDIPVTLVMDHPRLSDAADYLLVEVLGLGEQT----NVRQAS Mb1689|M.bovis_AF2122/97 AGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTG--------- Rv1661|M.tuberculosis_H37Rv AGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAGTG--------- MMAR_2471|M.marinum_M PGWSLQTAASVPVVFLTAFYGLRVLAEVRSGQKLLVHAATG--------- MAV_3109|M.avium_104 PGLSLVAAAGVPVVFLTALYGLSVLSGLRPGERVLVHTATG--------- MUL_2266|M.ulcerans_Agy99 ADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAATG--------- MLBr_00135|M.leprae_Br4923 QGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAGTG--------- TH_4621|M.thermoresistible__bu DGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLIHSATG--------- . :... : : : : : : MAB_0939|M.abscessus_ATCC_1997 AVTGRTDEPIAIVAVSCRFPGAPDPEAFWDVLS-GGVDAIREVPEDRFDI Mvan_0269|M.vanbaalenii_PYR-1 AAANRTDEPIAIVAVSCRFPGAPDPEAFWEVLA-GGVDAIREVPEDRFDI Mflv_0405|M.gilvum_PYR-GCK VVSTAADEPIAIVAVSCRFPGAPNPEAFWDLLS-GGVDAIREVPEDRFDI MSMEG_0408|M.smegmatis_MC2_155 TVTARTDDPIAVVAVSCRFPGAPDPESFWELLA-GGVDAIREVPEDRWDI Mb1689|M.bovis_AF2122/97 ----------GVGMAAVSLARYWGAEVFVTASR-AKWDTLRAMGFDDIHI Rv1661|M.tuberculosis_H37Rv ----------GVGMAAVSLARYWGAEVFVTASR-AKWDTLRAMGFDDIHI MMAR_2471|M.marinum_M ----------GVGMAAVQLARLWGLEVFATASP-GKWDTLRAMGFDDDHI MAV_3109|M.avium_104 ----------GVGMAAVQLARHYGAEVFATASR-GKWDTLRAMGFDDDHI MUL_2266|M.ulcerans_Agy99 ----------GVGMAAVQLARHLGLEVYATASK-GKWDILRAMGFDEDHI MLBr_00135|M.leprae_Br4923 ----------GVGMAAVQFARHWGVEIFVTASR-GKWDTLRDMGFDDDHI TH_4621|M.thermoresistible__bu ----------GVGLAAIAIARSVGAQIYATAGSPARRDLLRDMG--IEHV .: .: :. . : : . * :* : .: MAB_0939|M.abscessus_ATCC_1997 DEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLM Mvan_0269|M.vanbaalenii_PYR-1 DEFYDPDPDAAGKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLM Mflv_0405|M.gilvum_PYR-GCK DEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLM MSMEG_0408|M.smegmatis_MC2_155 DEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLM Mb1689|M.bovis_AF2122/97 SDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLR----LLPSGGRF Rv1661|M.tuberculosis_H37Rv SDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLR----LLPSGGRF MMAR_2471|M.marinum_M ANSRTLEFEEKFRAGTGGVGVDAVLNSLAGEFVDASLR----LLVPGGRF MAV_3109|M.avium_104 GDSRSPDFEQKFLAATGGAGVDVVLNSLAGEFTDASLR----LLAPGGRF MUL_2266|M.ulcerans_Agy99 SDSRSLEFEEKFREVTGGRSVDVVLDSLAGEFVDASLR----LLGPGGVF MLBr_00135|M.leprae_Br4923 GDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFVDASLR----LLVRGGRF TH_4621|M.thermoresistible__bu YDSRSTAFADEIRRDTDGYGVDVVLNSLPGAAQRAGLE----LLSFGGRF : * .. :: : . . : : MAB_0939|M.abscessus_ATCC_1997 LETVWEGLE-RAGYSPAALRGSRTGIFAGVGAN-EYAHLLSSESIDKIEP Mvan_0269|M.vanbaalenii_PYR-1 LETVWEGLE-RAGLAPADLRGSRTGIFVGVAAN-EYAHLLSSESIEKIEP Mflv_0405|M.gilvum_PYR-GCK LETVWEGLE-RAGYAPSALRGSRTGVFVGVAAN-EYAHLLSAESIDKIEP MSMEG_0408|M.smegmatis_MC2_155 LETVWEGLE-RAGYAPSDLRGSRTGVFTGVAAN-EYAHLLSAESIDKIEP Mb1689|M.bovis_AF2122/97 IELGKTDIR-DGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAA Rv1661|M.tuberculosis_H37Rv IELGKTDIR-DGQTVAERHRGVRYRAFDLVEAGPDRIAAMLSEVVGLLAA MMAR_2471|M.marinum_M IEMGKTDLR-DPQTMAEQHRGVGYRAFDLIEAGPDLIARMLAELSRLLCA MAV_3109|M.avium_104 IEMGKTDVR-DPDVVAQRYRGARYRAFDLMEAGPDRTAAMLAEIVGLLRA MUL_2266|M.ulcerans_Agy99 LEMGKTDIR-DPGVIAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDA MLBr_00135|M.leprae_Br4923 LEMGKTDIR-DAQEIAANYPGVQYRAFDLSEAGPVRMQEMLCEVRELFDT TH_4621|M.thermoresistible__bu IEIGKRDIYGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVYR :* .: : . MAB_0939|M.abscessus_ATCC_1997 YFITGNALNAISGRVAFALGFEGPAVAVDTACSSALVAVHQAVQALHSGD Mvan_0269|M.vanbaalenii_PYR-1 HFITGNALNAISGRVAFALGLEGPAVAVDTACSSALVAVHQACQALHSGD Mflv_0405|M.gilvum_PYR-GCK HFITGNALNAISGRVAFALGLEGPAVAVDTACSSSLVAVHQATQALRSGD MSMEG_0408|M.smegmatis_MC2_155 HFITGNALNAISGRVAFALGFEGPAVAVDTACSSALVAVHQACQALQSGD Mb1689|M.bovis_AF2122/97 GVLARLPVKTFDARCAPAA----YRFVSQARHIGKVVLTIPDGPGGQSG- Rv1661|M.tuberculosis_H37Rv GVLARLPVKTFDARCAPAA----YRFVSQARHIGKVVLTIPDGPGGQSG- MMAR_2471|M.marinum_M ETLTPLPIKTFDVRLARQA----YRFVSQARHIGKVVLTLPDETGAVPAG MAV_3109|M.avium_104 GVLTPLPLKTFDVRCASTA----YRYVSQARHIGKVVLTVPSGPGEVLSG MUL_2266|M.ulcerans_Agy99 GVLRPLPVTAFDVRRAPAA----LRYLSQARHVGKVVMTMPADQGGALG- MLBr_00135|M.leprae_Br4923 QVLHRLPVTSWDVRCAPAA----FRFMSQARHIGKVVLTMPSALADGLA- TH_4621|M.thermoresistible__bu LTADGVLPMPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVPHT------- . . : . : . :* MAB_0939|M.abscessus_ATCC_1997 CDLALAGGVNVLLSPVTVIAASRARMLSPVGRCKTFDASADGYVRSEGCG Mvan_0269|M.vanbaalenii_PYR-1 CDLALAGGVNVLLSPVTSVAASRARMLSPVGRCKTFDASADGYVRSEGCG Mflv_0405|M.gilvum_PYR-GCK CDMALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCG MSMEG_0408|M.smegmatis_MC2_155 CDLALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCG Mb1689|M.bovis_AF2122/97 ----LAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRA- Rv1661|M.tuberculosis_H37Rv ----LAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQADRA- MMAR_2471|M.marinum_M A---LAGGTVIITGGTGMAGTALARHVVSRHRVANVILVSRSGAQAEGT- MAV_3109|M.avium_104 CGGGLAQSTVLITGGTGMAGSALARHLVDRYRVGHVVLVSRTGAQAAGA- MUL_2266|M.ulcerans_Agy99 ------GGTVLITGGTGMAGSALARHLVAHHGVAHLVLISRRGPAAPGA- MLBr_00135|M.leprae_Br4923 ------EGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDRAEGA- TH_4621|M.thermoresistible__bu ------GRADVVVPPEQASPFRSDGAYIVTGGMGGLGLYLAGEMAAAGAG . :: . : MAB_0939|M.abscessus_ATCC_1997 ILVLKRLSDAERDGDRVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSV Mvan_0269|M.vanbaalenii_PYR-1 ILVLKRLGDAVRDGDRVCAVIPSSAVNQDGASSGLTVPNGGAQQRLIGMA Mflv_0405|M.gilvum_PYR-GCK ILVLKRLSDAVRDGDRVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTV MSMEG_0408|M.smegmatis_MC2_155 VLVLKRLSDAVRDGDRVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEAT Mb1689|M.bovis_AF2122/97 ----AEVAALLREGGAQVAVVSCDVADRD-ALAALLAGLDPRYP-LKGVF Rv1661|M.tuberculosis_H37Rv ----AEVAALLREGGAQVAVVSCDVADRD-ALAALLAGLDPRYP-LKGVF MMAR_2471|M.marinum_M ----SELLGQLQDAGAEAAVVACDVSDRD-AVAELLAQVPARYP-LRGVI MAV_3109|M.avium_104 ----AELVDELQRAGASASVLACDVGDRD-AVATMLAGLPSGYP-LRGIV MUL_2266|M.ulcerans_Agy99 ----TELVAELSAAGAQVEVVACDAADRP-ALAKVIAENPAQRP-LSAVV MLBr_00135|M.leprae_Br4923 ----VELAAELVGAGAKIQVVACDVADND-AVRGLFAQLSREFPPVRGVI TH_4621|M.thermoresistible__bu -----CIVLNGRSAPSGEALRTIEQLRAAGTEVIVECGXXXRGQPVEVAV : . : . . : : : MAB_0939|M.abscessus_ATCC_1997 LARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAAAAYGGSRDADRPLLMGS Mvan_0269|M.vanbaalenii_PYR-1 LARAGLSGGDVDYLEAHGTGTPLGDPIEVQAAAAAYGASRDADRPLLMGS Mflv_0405|M.gilvum_PYR-GCK LARAGITGGEVDYLEAHGTGTPLGDPIEVQAAAAAYAGARDADRPLLMGS MSMEG_0408|M.smegmatis_MC2_155 LARAGLSGADVDYLEAHGTGTPLGDPIEVQAAAAAYGAGRDADRPLLMGS Mb1689|M.bovis_AF2122/97 HAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSS Rv1661|M.tuberculosis_H37Rv HAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAFVVFSS MMAR_2471|M.marinum_M HAAGVLDDGLIASLTPQRVDTVLRAKIDGAWNLHELTRGLNLSAFVLFSS MAV_3109|M.avium_104 HAAGILDDGLLSSLTPDRVDAVLRAKVDGAWNLHELTKDLDLSAFVVFSS MUL_2266|M.ulcerans_Agy99 HAGGVLDDAVISSLTPERVDTVLRAKVDAAWNLHELTRDLDLSAFVMFSS MLBr_00135|M.leprae_Br4923 HAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSS TH_4621|M.thermoresistible__bu PTELRHADEHPDRRGAQLCDEFARGEQGAQRNQHRTDAGEGQRDAHPPGA : . .. . . .: MAB_0939|M.abscessus_ATCC_1997 VKSNIGHTESASGAAGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVR Mvan_0269|M.vanbaalenii_PYR-1 VKTNIGHLESASGAAGLIKVVLSLQHNLLPQSLHFENPSPHIPWDSLPVR Mflv_0405|M.gilvum_PYR-GCK VKTNIGHTESASGAAGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVR MSMEG_0408|M.smegmatis_MC2_155 VKTNIGHTESASGAAGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVR Mb1689|M.bovis_AF2122/97 MAGIVGTPAQGNYAA-----ANAFLDGLVAYRRSRGLAGLSVAWG-LWEQ Rv1661|M.tuberculosis_H37Rv MAGIVGTPAQGNYAA-----ANAFLDGLVAYRRSRGLAGLSVAWG-LWEQ MMAR_2471|M.marinum_M MAGIIGTAGQGNYAA-----ANSFLDGLAVHRRALGLPGVSVAWG-LWEQ MAV_3109|M.avium_104 MAGIVGTPGQANYAA-----ANSFLDGLVAHRRADGLAGLSLAWG-LWEQ MUL_2266|M.ulcerans_Agy99 MAGVVGSSGQANYAA-----ANTFVDGLAAHRRAHGLPAISLGWG-LWDQ MLBr_00135|M.leprae_Br4923 IAATVGSPGQGNYSA-----ANAFLDGLAAYRQAAGLAGTSLAWG-LWEQ TH_4621|M.thermoresistible__bu VGHDQPDPGALSDTG-------------------LDERGGQFPGVGVQIP : . :. . . : MAB_0939|M.abscessus_ATCC_1997 VVDKAIPWQANGRPRRAGVSSFGFTGTNAHVLIEEAPQPQATP------- Mvan_0269|M.vanbaalenii_PYR-1 VVDKAIPWQADGRPRRAGVSSFGFTGTNAHVLIEEAPLPQAAD------- Mflv_0405|M.gilvum_PYR-GCK VVDTAMPWQPNGRPRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPA MSMEG_0408|M.smegmatis_MC2_155 VIDEPVPWQTNGRVRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP--- Mb1689|M.bovis_AF2122/97 ASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTA-------------- Rv1661|M.tuberculosis_H37Rv ASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTA-------------- MMAR_2471|M.marinum_M ASAMTRHLGERDKARMSRVGLATLSTEHALELFDAA-------------- MAV_3109|M.avium_104 ASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAA-------------- MUL_2266|M.ulcerans_Agy99 ASDMTGGMDAADRARLGREGVLALSSDEAMELFDTA-------------- MLBr_00135|M.leprae_Br4923 PGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAA-------------- TH_4621|M.thermoresistible__bu VADPGVGIDHRGAVR----------------------------------- . * MAB_0939|M.abscessus_ATCC_1997 ---DEDDASTPQSAPVSVLPLSARSPEALAAVAQRYESWLAAHPDVDLED Mvan_0269|M.vanbaalenii_PYR-1 ---PVEEPDT-RALPVGVLALSARSPEALTALAQRYEAWLSAHPDADLAD Mflv_0405|M.gilvum_PYR-GCK EPVDEDAAADPAPAPVEVLPLSARSPEALVALAQRYETWLTAHPEADLAD MSMEG_0408|M.smegmatis_MC2_155 -VEPAATAEAGTDDSPQVLALSARSPEALVELARRYDDWLSATPGLDIAD Mb1689|M.bovis_AF2122/97 ------LQADRAVVVAARLDRAALAGAGAA--LPALFSQLAAGPTRRRI- Rv1661|M.tuberculosis_H37Rv ------LQADRAVVVAARLDRAALAGAGAA--LPALFSQLAAGPTRRRI- MMAR_2471|M.marinum_M ------VVADRAVVVATRLDANALKSNSAA--LPPLLGELAARPKRRVIS MAV_3109|M.avium_104 ------MLVETPVLVAARLDRAALSENIAA--LPPLLRELAAGPTRRVI- MUL_2266|M.ulcerans_Agy99 ------LIVNQAFLAPARIDLAALRAHAVA--VPPMFSDLVSAPTRRQID MLBr_00135|M.leprae_Br4923 ------LVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIE TH_4621|M.thermoresistible__bu --------VDSGVPAQQGVDGEVVRHRTLSSVRSGRSSRWTAPGSRCGSG : . MAB_0939|M.abscessus_ATCC_1997 VCLTAGRGRSHFEHRAALVVDSIQTAREGLLELAQNRLRPGVVRGEHTNH Mvan_0269|M.vanbaalenii_PYR-1 VCRTAGTGRSHFEHRAALVVDSVAAAREGLAELAQNRLRPGVVRGEHTHH Mflv_0405|M.gilvum_PYR-GCK VCRTAGTGRSHFEHRAALVVDSVESARIALTDLAQNRLRPGVVRGEHLNH MSMEG_0408|M.smegmatis_MC2_155 VCHTAGVGRSHFEYRAALVVDSVERAREGLAALAEGRTPAGVVRGEHVHR Mb1689|M.bovis_AF2122/97 --DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR------ Rv1661|M.tuberculosis_H37Rv --DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR------ MMAR_2471|M.marinum_M DADAGDNIAAATGLVARLHGLSAEQRQRELVDVVCSNAATVLGR------ MAV_3109|M.avium_104 --DDADVTASMSGLAARLHGLSPEARRRELVDLVCGNAAMVLGV------ MUL_2266|M.ulcerans_Agy99 --AALATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGT------ MLBr_00135|M.leprae_Br4923 --DPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGR------ TH_4621|M.thermoresistible__bu RRYGGESCRRTTGPAAGAAARRGRTRRR---------------------- MAB_0939|M.abscessus_ATCC_1997 PTTAWLFTGQGSQYPGMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEV Mvan_0269|M.vanbaalenii_PYR-1 PTTAWLFTGQGSQFPGMARELFETEPVFADAVTRCADAVKDILPRPLLEV Mflv_0405|M.gilvum_PYR-GCK PTTAWMFTGQGSQYPGMARELFDTEPVFADTVTRCADAVADLLPRPLLDV MSMEG_0408|M.smegmatis_MC2_155 PTTAWLFTGQGSQYPGMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDV Mb1689|M.bovis_AF2122/97 -------SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF Rv1661|M.tuberculosis_H37Rv -------SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLSPTLIF MMAR_2471|M.marinum_M -------SSTADINAHRAFQELGFDSLTAVELRNRLKTATGLTLSPTLIF MAV_3109|M.avium_104 -------PDPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLSPTLIF MUL_2266|M.ulcerans_Agy99 -------ITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIF MLBr_00135|M.leprae_Br4923 -------PSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATGLTLPPTVIF TH_4621|M.thermoresistible__bu -------------------RRPRRPPPPPDRVRHRAGPAHGPVRR----- . . . : . . . MAB_0939|M.abscessus_ATCC_1997 MFATDRETGGKAGEALRHTSFAQPALFAVEMG------------------ Mvan_0269|M.vanbaalenii_PYR-1 LFAADRESG----EALRHTSFAQPAIFAVEMG------------------ Mflv_0405|M.gilvum_PYR-GCK MFAGGREAGVPPTETLRHTSFAQPALFAVEMG------------------ MSMEG_0408|M.smegmatis_MC2_155 LFATDRETA----DLLQHTSFAQPALFAVEMG------------------ Mb1689|M.bovis_AF2122/97 DYPTPATLAEHLDSRLVTASGSDQQSLSDRVD------------------ Rv1661|M.tuberculosis_H37Rv DYPTPATLAEHLDSRLVTASGSDQQSLSDRVD------------------ MMAR_2471|M.marinum_M DYPSPAALAEHLGIRLATAT--AQPDLMRRFD------------------ MAV_3109|M.avium_104 DYPTPVVLAEHLDSRLAGSGGDDQPDLMGRFN------------------ MUL_2266|M.ulcerans_Agy99 DYPTPNGLANYIRAELAGAPQEVKHTPAVRVTGDDPIAIVGMSCRYPGGI MLBr_00135|M.leprae_Br4923 DHPTPTAVAEYVAQQMLKSR------------------------------ TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ----------------LARLWQSWGIEPDVVLGHSVGQYAAACVAG---- Mvan_0269|M.vanbaalenii_PYR-1 ----------------LARLWQSWGIEPDVVLGHSVGQYAAACVAG---- Mflv_0405|M.gilvum_PYR-GCK ----------------LARLWQSWGIVPDVVLGHSVGQYAAACVAG---- MSMEG_0408|M.smegmatis_MC2_155 ----------------LARLWQSWAIEPDVVLGHSVGQYAAACVAG---- Mb1689|M.bovis_AF2122/97 ----------------------DITRELVVLLD-QPDLS----------- Rv1661|M.tuberculosis_H37Rv ----------------------DITRELVVLLD-QPDLS----------- MMAR_2471|M.marinum_M ----------------------DLARELDKLIN-RPDWT----------- MAV_3109|M.avium_104 ----------------------DITRELQALLG-APHWN----------- MUL_2266|M.ulcerans_Agy99 ESPDDLWDMLMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFV MLBr_00135|M.leprae_Br4923 ---------------------------PAES------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ----------VFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQI Mvan_0269|M.vanbaalenii_PYR-1 ----------VFSLEDGARLMAERGRMFGSLPEGGRMVAVFTDAKLVEEI Mflv_0405|M.gilvum_PYR-GCK ----------VFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQV MSMEG_0408|M.smegmatis_MC2_155 ----------VFSLDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQV Mb1689|M.bovis_AF2122/97 -------------ANVKAHLRTRLQTMLTSLTT--------EDDDIAAAT Rv1661|M.tuberculosis_H37Rv -------------ANVKAHLRTRLQTMLTSLTT--------EDDDIAAAT MMAR_2471|M.marinum_M -------------HEDKGKLSGRLHDILADLS---------ADDDITTAS MAV_3109|M.avium_104 -------------SDDKAVLRARIHGLLGALPAGDGPDSAPLDEDLEAAT MUL_2266|M.ulcerans_Agy99 DRVGDFEPAFFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSA MLBr_00135|M.leprae_Br4923 ------------------------------------------GDETSQAV TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AGEFPRVSVGAYNG------------------------------------ Mvan_0269|M.vanbaalenii_PYR-1 AGDFPRVSVGAYNG------------------------------------ Mflv_0405|M.gilvum_PYR-GCK AADFPRVSVGAYNG------------------------------------ MSMEG_0408|M.smegmatis_MC2_155 AGEFPRVSVGAYNG------------------------------------ Mb1689|M.bovis_AF2122/97 ESQLFAILDEELGS------------------------------------ Rv1661|M.tuberculosis_H37Rv ESQLFAILDEELGS------------------------------------ MMAR_2471|M.marinum_M ESQLFAILDEELGS------------------------------------ MAV_3109|M.avium_104 ESQLFAILDEELGR------------------------------------ MUL_2266|M.ulcerans_Agy99 TGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSV MLBr_00135|M.leprae_Br4923 EPKVEEVSVHA--------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 DTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ADGRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 DGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAM MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 RHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 FGISGTNAHVIVEAAPRVEVGGSSGGAVPVVPWVVSAKSGSALGAQAARL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AAHVRSHDELDVADVGWSLAGRSTFEHRAVVLGADRDGLLAGLDELAGDE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 FGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEAFNTVV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GELDRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLESWGVR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_0269|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGAMIAVQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ----------------------PNTVLSGPGEDLEQAVARFQEEGIRCTW Mvan_0269|M.vanbaalenii_PYR-1 ----------------------PNTVLSGPGEDLEQIVDRFGDDGVRCTW Mflv_0405|M.gilvum_PYR-GCK ----------------------PNTVLSGPGEDLEQIVGTFGEDGIRCTW MSMEG_0408|M.smegmatis_MC2_155 ----------------------PNTVLSGPGEDLEEIVERFEDEGIRCTW Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ATEQEVLPLLGAQVSIATINGPASVVISGAQDAVSAVAEQLRADGRRVHR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LETSHAFHSELLDPILDEFESYAAQVQFAAPTLPLVCNRTGAVLTAQTPI Mvan_0269|M.vanbaalenii_PYR-1 LQTSHAFHSELLDPVLDEFESYAAQFQFATPTLPLVCNRTGTVLTAQTPL Mflv_0405|M.gilvum_PYR-GCK LETSHAFHSELLDPVLDEFESYAAQLQFAAPTLPLVCNRTGAVLTGQTSL MSMEG_0408|M.smegmatis_MC2_155 LATSHAFHSELLDPVLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTGQTPL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LAVSHAFHSPLMDPMIDEFATVAGELTVNAPTIGIISNLT-GQLAGEDFG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DGQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEH Mvan_0269|M.vanbaalenii_PYR-1 DAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGSAVQVWPEH Mflv_0405|M.gilvum_PYR-GCK DAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEH MSMEG_0408|M.smegmatis_MC2_155 DAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEH Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SAAYWKRHVRDAVRFADSIRFAQSAGAARFLEVGPSIGLTASIEEVLSDA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LAPP--RAIVSLRKGVEDRRQIADALASAYVSGHRPNFAALQRHPRRTVE Mvan_0269|M.vanbaalenii_PYR-1 LAAP--RAIVSLRKGVSDRRQITEALAAAYVGGHRPDFGALYRRPGRAVA Mflv_0405|M.gilvum_PYR-GCK LAAP--RAIASLRKGVADRRQIADALAAAYIGGHKPDFAALHEQRGVRLE MSMEG_0408|M.smegmatis_MC2_155 MAAP--RAVASLRKGVADRRQIADALASAYVGGHRPDFAAVHRQPRRPVE Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AVTNPVATASALRKDRPEPVSLVSALAGVFVAGTAVDWRAVVGQS-HFVE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LPTYPFQRRRFWPKSSGTAIEGGGGLPSG-----ILGRGEDLASGDSVYI Mvan_0269|M.vanbaalenii_PYR-1 LPTYPFQRRRFWPKTSGITTDG--PAVSG-----ILGSAKDLASGDTVYT Mflv_0405|M.gilvum_PYR-GCK LPTYPFQRRRFWPKSAGMAIDGRVGASAGSG---ILGSGKDLASGDSVYT MSMEG_0408|M.smegmatis_MC2_155 LPTYPFQRRRFWPKASSIAVDGG-TAASG-----ILGSGKDLASGDTIYT Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LPTYAFERRRFWLSGDAVPADAAGLGLQAGEHALLGAVVELPASGGVVLT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SRLSVRSQPWLSDHVIYGTVVVPGATYAAMALAAVGTPARAKDVFFYEPI Mvan_0269|M.vanbaalenii_PYR-1 SRWSVRSQPWLADHVIYGTVVVPGATYAAMALAAVGTPARVKDVFFYEPI Mflv_0405|M.gilvum_PYR-GCK SRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAVGTPAHAKDVFFYEPI MSMEG_0408|M.smegmatis_MC2_155 SRLSVKSQPWLADHVIYGTVVVPGATYAAMALAAVGTPARLKDVFFYEPI Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GRLSLAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTG Mvan_0269|M.vanbaalenii_PYR-1 ILPEKASREVQLTLHPSEDG-GQKFQVHSREYGERGTEWSLNAEGTVASG Mflv_0405|M.gilvum_PYR-GCK ILPEKSSREVQLTVHPSVDG-ESKFQVHSRPYGERGAEWALNAEGVVASG MSMEG_0408|M.smegmatis_MC2_155 ILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PLVLPSGGSVAVQVVVGSPDDSGARAVSVYSRGDAGSDWVLHAEGSLGSG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAWGPTWSG Mvan_0269|M.vanbaalenii_PYR-1 VDENPQ-----AEPSGPVDEAIERLNRMRPQDLFETFADMELAWGPTWSG Mflv_0405|M.gilvum_PYR-GCK VGDSPAAAG---DLEDPVDEAIERLNRMRPQELFETFADLELAWGPTWSG MSMEG_0408|M.smegmatis_MC2_155 GSDPDAAAD---EQSDPVDEVIERLERMRPQDLFETFADLELAWGPTWSG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SPEPATDLS---------TWPPVGAVEVENADGYQQLAERGYGYGPAFR- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPAL Mvan_0269|M.vanbaalenii_PYR-1 SLKSLWLGEGEAIGDILVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPAL Mflv_0405|M.gilvum_PYR-GCK SLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPAL MSMEG_0408|M.smegmatis_MC2_155 SLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPAL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GLNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDAALHAVILASDGA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLD Mvan_0269|M.vanbaalenii_PYR-1 LAAEQGVSDLFLPLRYGQVTLRDKMPRRFYCRATWHTSELDSETQVFDLD Mflv_0405|M.gilvum_PYR-GCK LAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLE MSMEG_0408|M.smegmatis_MC2_155 LAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELE Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 DDFGVPEGSVLVPFAWQGVTLHAAG------ASAVRARIAPAGPSAVSIE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 YLDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVAVPPV Mvan_0269|M.vanbaalenii_PYR-1 FLDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPAPAS Mflv_0405|M.gilvum_PYR-GCK YLDRDGRHLGGVREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPVPES MSMEG_0408|M.smegmatis_MC2_155 FVDLGGRALGGIREFTVKRAPREALLRGLGGDATRLLYTLGWHEVPPPPS Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LSDGLGLPVLSVASMLARPVTDQQLRAAVSGAGPDRLFGVDWTAQPSAEL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRETDPELLGEVLVAAKE Mvan_0269|M.vanbaalenii_PYR-1 G-----DAALNGNWLIAGFDELAAGVPGCIPFDRSTDPEPLGQLLAQAHE Mflv_0405|M.gilvum_PYR-GCK G----DGAAPQGTWLIGGFDELAVSVPGCIPADR-TNPESLRQLLTDAHG MSMEG_0408|M.smegmatis_MC2_155 A------DDAVGTWLIAGFDELAAKVPGCVPIDRNTDLQVLGEVLSQAHA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 Q-------------------PVPVRIWGTVESEGDDDPGASVVFESVPQA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNSAQN Mvan_0269|M.vanbaalenii_PYR-1 RGIGFSGVVWRAAAPSADES--STAMAARIETEIADLLSAVHTVQN---G Mflv_0405|M.gilvum_PYR-GCK RGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQG---G MSMEG_0408|M.smegmatis_MC2_155 RGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQG---P Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GEVVAGVYAATAAVLEVLRS----------------------------WL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRAKLV Mvan_0269|M.vanbaalenii_PYR-1 AVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRCRLV Mflv_0405|M.gilvum_PYR-GCK EVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRCRLV MSMEG_0408|M.smegmatis_MC2_155 SVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHCRLV Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SRDGAGQLIITTRGAVALPDEDVTDLAGSAVWGLVRSAQTEHPGRIVLVD MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGHLTVP Mvan_0269|M.vanbaalenii_PYR-1 DVDGSPEAVLALAGLLAAP-VDEPELAVRQGKLLASRLLPWARSGHLTVP Mflv_0405|M.gilvum_PYR-GCK DCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGHLTVP MSMEG_0408|M.smegmatis_MC2_155 DCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGHLTLP Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TDAQLDEHAVAAVLAAGEPQVLWRNGEVYTARVHGSRAV----AGLLVPP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RGSDYVLAPTERGAIDNLRITEKEVPAPD--EGYVQVRVEAAGLNFRDVL Mvan_0269|M.vanbaalenii_PYR-1 RSADYVLAPTERGAIDNLRLTETDVAPPA--EGYVQVRVEAAGLNFRDVL Mflv_0405|M.gilvum_PYR-GCK RGGDYVLAPTERGAIDNLRLTDSEVPPPA--EGYVQVRVEAAGLNFRDVL MSMEG_0408|M.smegmatis_MC2_155 RGGDFVLAPTERGAIDNLRLTETDVPEPD--EGYVQVRVEAAGLNFRDVL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GDGPWRLGMSTAGTFENLRLEPIPDADAALQPGHVRVALSAMAANFRDVM MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 NVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFGSRFN Mvan_0269|M.vanbaalenii_PYR-1 NVLGLYPGDPGPIGGDFAGTVTQLGSGVTGLEVGQRVYGFMQGAFASRFN Mflv_0405|M.gilvum_PYR-GCK NVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFASRFN MSMEG_0408|M.smegmatis_MC2_155 NVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFASRFN Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 IALGLYPDPDAAMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGTGTIAI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VPAQFLAPIPDGISGVEAATIPAAALTVR-LSFDWAQLKPGDKVLIHAAS Mvan_0269|M.vanbaalenii_PYR-1 VPAQLLAPIPDGIGAVDAATIPAAALTAR-LAFDWAQLKPGDRVLIHAAS Mflv_0405|M.gilvum_PYR-GCK VPGQFLAPIPDGVSAVEAATIPAAALTVR-LSFDWAQVKSGDKVLIHAAS MSMEG_0408|M.smegmatis_MC2_155 VPAQFLAPIPDGIGAVEAATIPAAALTVR-LAFDWAQLKPGDKVLIHAAS Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TDHRLLVKIPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAAT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GGVGLAAIQMAQQFGAEVFATASTFKRATLRKLG--VKYVYDSRTTDFAD Mvan_0269|M.vanbaalenii_PYR-1 GGVGLAAIQMAQQHGAVVFATASTYKRATLRKLG--VDHVYDSRTTEFAD Mflv_0405|M.gilvum_PYR-GCK GGVGLAAVQMAQQCGAEVYATASTFKRATLRKLG--VKHVYDSRTTDFAE MSMEG_0408|M.smegmatis_MC2_155 GGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLG--VKYVYDSRTTDFAD Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GGVGMAAVQLARHWGLEVFATASKGKWDTLRAMGFDEDHIGDSRSLEFED MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 QILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTTEQ Mvan_0269|M.vanbaalenii_PYR-1 QILADTDGEGVDVVLNSLTNEGFIEATVRATAQNGRFAEIAKRDIWTPEQ Mflv_0405|M.gilvum_PYR-GCK QILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTVEQ MSMEG_0408|M.smegmatis_MC2_155 QILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSHEQ Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 KFRAATGGRGMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIREAAV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 MAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKG------EWTP Mvan_0269|M.vanbaalenii_PYR-1 MAAARPDIAYEIVALDTVTLLEPERIRGLLGEVSDGLGKADGSSRAEWVP Mflv_0405|M.gilvum_PYR-GCK MAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDG------AWTP MSMEG_0408|M.smegmatis_MC2_155 MAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARG------EWTP Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VAQQHTGVRYRAFDLFEAGPDHIAQILAELAALFSEDVLR---------P MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPRPDRTYLITGGLG Mvan_0269|M.vanbaalenii_PYR-1 LPAEIYPLTEARAAFRRMQQARHVGKIVLQMPKPLQPRADRSYLITGGLG Mflv_0405|M.gilvum_PYR-GCK LPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQPDRSYLITGGLG MSMEG_0408|M.smegmatis_MC2_155 LPAEIYPITEARSAFRRMQQARHIGKIVLQVPKPLQPQQDRSYLITGGLG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LPVTTFDVRRAPAALRYLSQARHVGKVVLTMPDAWAAG---TVLITGGTG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHVFT Mvan_0269|M.vanbaalenii_PYR-1 AIG-LHTAAYLAQLGAGDLVLTSRRAPDADARRAIEEITERYKCRVHTFC Mflv_0405|M.gilvum_PYR-GCK AIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHVFT MSMEG_0408|M.smegmatis_MC2_155 AIG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 MAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQVVA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRTTL Mvan_0269|M.vanbaalenii_PYR-1 ADVGDESQVAELLARIRAELPPLAGVAHLAGVLDDALLSQQSLERFRTTL Mflv_0405|M.gilvum_PYR-GCK ADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRTAL MSMEG_0408|M.smegmatis_MC2_155 ADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 CDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVVTSLTPERIETVL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 APKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLDGL Mvan_0269|M.vanbaalenii_PYR-1 APKAFGACHLDRLTAGDDLDFFIMSSSVSSLFGSPGQANYATANALLDGL Mflv_0405|M.gilvum_PYR-GCK APKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGL MSMEG_0408|M.smegmatis_MC2_155 APKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 RAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLDGL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IAQRRAQGLPATGINFGPWGQGGMASSEAATAN------------ISAQG Mvan_0269|M.vanbaalenii_PYR-1 TAHRRARGLPATGVNFGPWAQGGMASSEAATAN------------IGAQG Mflv_0405|M.gilvum_PYR-GCK VAQRRAQGLPATGVNFGPWARGGMASSEAAAAN------------ISAQG MSMEG_0408|M.smegmatis_MC2_155 VAKRRAQGLVATGINFGPWGQGGMASSEAATAN------------ITAQG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSDEA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LIPLDPSAALAALAEVVANGTGQATILKANWQRAAKVLGSSRPPILDLVL Mvan_0269|M.vanbaalenii_PYR-1 LVPLEPSAALGALAEVLANGTGQAAVLKANWQRAAKVLGSSRPPILDLVL Mflv_0405|M.gilvum_PYR-GCK LIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSSRPPILDLVL MSMEG_0408|M.smegmatis_MC2_155 LIPLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLGSARPPILDLVL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRRQV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PSAVGEVTGDSELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPP--A Mvan_0269|M.vanbaalenii_PYR-1 PRPEGEVAGDSELLRQLQEIPVAQRAGFVTEFLQREVQNFLRLAQPP--A Mflv_0405|M.gilvum_PYR-GCK PSAVGEITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPP--A MSMEG_0408|M.smegmatis_MC2_155 PSAAGEATGDSELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPP--A Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 DDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDAID MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ATSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYL Mvan_0269|M.vanbaalenii_PYR-1 ATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEYL Mflv_0405|M.gilvum_PYR-GCK ATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEYL MSMEG_0408|M.smegmatis_MC2_155 ASSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAGYM MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGQLPDADAESAEAPPAVESAEAESGAGPAAASDAVSELKE--------- Mvan_0269|M.vanbaalenii_PYR-1 VGQLPDSDAAAGETPATETSPIDHNHPDREADSPG--------------- Mflv_0405|M.gilvum_PYR-GCK VAQLPD-----AETPQAAPQSESEPGPDVTE------------------- MSMEG_0408|M.smegmatis_MC2_155 VGQLPD-----AEAPETA-------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 HRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQAGVLELLLALANE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ------------------------------------ Mvan_0269|M.vanbaalenii_PYR-1 ------------------------------------ Mflv_0405|M.gilvum_PYR-GCK ------------------------------------ MSMEG_0408|M.smegmatis_MC2_155 ------------------------------------ Mb1689|M.bovis_AF2122/97 ------------------------------------ Rv1661|M.tuberculosis_H37Rv ------------------------------------ MMAR_2471|M.marinum_M ------------------------------------ MAV_3109|M.avium_104 ------------------------------------ MUL_2266|M.ulcerans_Agy99 TGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE MLBr_00135|M.leprae_Br4923 ------------------------------------ TH_4621|M.thermoresistible__bu ------------------------------------