For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMGCRYPGGVDSPEALWEMVVEGRDVVSEFP ADRGWDLAGLFDADPDAVGKSYCRCGGFLTGVGDFDAAFFGIAPSEALAMDPQQRLLLEVSWEALERAGI DPATLRGSATGVFAGIFHGSYGGQGRVPGNLERYGLRGSTLSVASGRVAYALGLEGPAVSVDTACSSSLV ALHLAAQSLRSGECDLALAGGVTVMATPAMFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERL SDARRLGHSVLAVLRGSAVNQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEGHGTGTMLGDPI EAQALLATYGQDRPVDEPLWLGSIKSNMGHTSAAAGAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSAG AVSLLTEARPWPARDRPRRAGVSSFGISGTNAHVIVEQYEPETVAPQGGDVVVPWVLSARSAEALTNQAA RLLARVKADPGVRVLDVGWSLVSTRSRFEHRAVIVGADGAQLLRRLADLAGGQPGAGVVTGRAQPVGKTV FVFPGQGSQWPGMGAQLLDRSTVFAEHMHRCARALAEHVDWSLIDVIRGAPGAPGLDRVDVVQPALWAVM VSLAELWRSVGVVPDAVIGHSQGEIAAACVAGALSLHDAARVVALRSRLLVRLSGRGGMVSLACGRSRAE QLIAPWGERLNIATVNGISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEIRDSLAEALR GIAPRSSAVAFFSTVTGELMDTAALDGDYWFRSIRQTVQFERAVRGAAEAGYRAFIECSPHPVLTAAIEE TMPDGGQGCVIPSLGRDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDLPTYGFVRQHFWLPGGS TGSSDVAALGLRGAEHGLLGAVLPRPDSGGVVLTGRLSTSAQAWLADHAVGDTVLFPGAGFVELAIRAGD EVGCGVIDELTLSAPLPLPASGGVRLQLVVGAPDEAGRRPLSVYSAAAHQDSEWMLHAEGVLRTGTVTPA GDLSIWPPIGATAVDVTGGYARLAQRGYEYGRAFRGLRAMWQRGDEIFAEVALPDDAAAGDDFGVHPVLL DAALHALGVAGEKDQTVLPFSWQGVALHASGASRARVRIAPAGAGAVSVELADGAGLPVLSVRSVTMRPV SPGQLSAAMGTAQPSGLLDVIWSPIALGGNDLGDEVTLWEPGEHGGDVVKSVHAAVTETLAVLQSWLDGE GAGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGRLVLIDSDGSLDARAVIPCGEPQVVVRQG VAHAARLRPARAGATLGLPSGAWRLDAGGEGTLGDLVVSRCPRTELADGQVRVAVAAVGVNFRDVLVALG MYPGGGRLGAEGAGVVVEVGPAVTGLAVGDPVMGLLGVVGSEAVVDQRLLTAVPPGLSLVAAAGVPVVFL TALYGLSVLSGLRPGERVLVHTATGGVGMAAVQLARHYGAEVFATASRGKWDTLRAMGFDDDHIGDSRSP DFEQKFLAATGGAGVDVVLNSLAGEFTDASLRLLAPGGRFIEMGKTDVRDPDVVAQRYRGARYRAFDLME AGPDRTAAMLAEIVGLLRAGVLTPLPLKTFDVRCASTAYRYVSQARHIGKVVLTVPSGPGEVLSGCGGGL AQSTVLITGGTGMAGSALARHLVDRYRVGHVVLVSRTGAQAAGAAELVDELQRAGASASVLACDVGDRDA VATMLAGLPSGYPLRGIVHAAGILDDGLLSSLTPDRVDAVLRAKVDGAWNLHELTKDLDLSAFVVFSSMA GIVGTPGQANYAAANSFLDGLVAHRRADGLAGLSLAWGLWEQASAMTAHLGDRDKARMSRIGLAPLSTEQ ALAAFDAAMLVETPVLVAARLDRAALSENIAALPPLLRELAAGPTRRVIDDADVTASMSGLAARLHGLSP EARRRELVDLVCGNAAMVLGVPDPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLSPTLIFDYPTPV VLAEHLDSRLAGSGGDDQPDLMGRFNDITRELQALLGAPHWNSDDKAVLRARIHGLLGALPAGDGPDSAP LDEDLEAATESQLFAILDEELGR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. avium 104 | MAV_3109 | - | - | 100% (2124) | RifB protein |
M. avium 104 | MAV_3108 | - | 0.0 | 64.31% (2146) | erythronolide synthase, modules 3 and 4 |
M. avium 104 | MAV_2450 | - | 0.0 | 62.01% (2077) | erythronolide synthase, modules 3 and 4 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1689 | pks7 | 0.0 | 71.26% (2143) | polyketide synthase pks7 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 37.15% (2148) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv1661 | pks7 | 0.0 | 71.30% (2143) | polyketide synthase pks7 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 56.16% (2094) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 37.24% (2143) | polyketide synthase |
M. marinum M | MMAR_2471 | pks7 | 0.0 | 70.80% (2137) | polyketide synthase Pks7 |
M. smegmatis MC2 155 | MSMEG_4727 | - | 0.0 | 33.50% (2149) | mycocerosic acid synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 37.60% (1202) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 61.17% (2073) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 37.76% (2156) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK -----------------------------MGSAAHQGESAHR-FAIVGYA MAB_0939|M.abscessus_ATCC_1997 -----------------------------MDSAENPIESTPR-FAIIGYA Mvan_1003|M.vanbaalenii_PYR-1 ---------------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYA Mb1689|M.bovis_AF2122/97 -------MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMG Rv1661|M.tuberculosis_H37Rv -------MNSTPEDLVKALRRSLKQNERLKRENRDLLARTTEPVAVVGMG MMAR_2471|M.marinum_M -------MDSTPDELITALRKTLKENERLKRENRDHLAQATEPVAVVGMG MAV_3109|M.avium_104 -------MSGDTEELVRALRQSLKENERLKRENRRYLVAATEPVAVVGMG MUL_2266|M.ulcerans_Agy99 -------MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMS MLBr_00135|M.leprae_Br4923 MTASVEGADQKSEKLISYLKKVVVELDETRARLREYEQRATEPVAVVGIG MSMEG_4727|M.smegmatis_MC2_155 -----------------------------------MTQNCVAPVAIIGMA TH_4621|M.thermoresistible__bu --------------------------------VNIVGDTPVNAVAVIGMA *::* . Mflv_0405|M.gilvum_PYR-GCK GRFPGARD-AESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVV MAB_0939|M.abscessus_ATCC_1997 ARFPGAAD-AEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVV Mvan_1003|M.vanbaalenii_PYR-1 LRFPGAAD-ADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMV Mb1689|M.bovis_AF2122/97 CRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSY Rv1661|M.tuberculosis_H37Rv CRYPGGVDSPETLWELVAHGRDAVSEFPADRGWDVAGLFDPDPDAVGKSY MMAR_2471|M.marinum_M CRYPGGIETPEGLWEMVAAGRDVVSDFPTDRGWDGASLFDPDPDAVGKSY MAV_3109|M.avium_104 CRYPGGVDSPEALWEMVVEGRDVVSEFPADRGWDLAGLFDADPDAVGKSY MUL_2266|M.ulcerans_Agy99 CRFPGGVDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSY MLBr_00135|M.leprae_Br4923 CRFPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTY MSMEG_4727|M.smegmatis_MC2_155 CRLPGAINSPQQLWEALLRGDDFVTEIPTGR-WDAEEYYDPEPGVPGRSV TH_4621|M.thermoresistible__bu CRLPGGIDSPQRLWEALLRGDDMVTEIPVDR-WDADDYFDPEPGVPGRTV * **. : .: :*: : * :::.* .* ** :*.:* . : Mflv_0405|M.gilvum_PYR-GCK TRRAGFVDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAP MAB_0939|M.abscessus_ATCC_1997 TRRAGFVEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAP Mvan_1003|M.vanbaalenii_PYR-1 TRRAGFVEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAP Mb1689|M.bovis_AF2122/97 TRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP Rv1661|M.tuberculosis_H37Rv TRCGGFLTDVAGFDAEFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP MMAR_2471|M.marinum_M TRSGGFLTDVAGFDAEFFGIAPSEVMAMDPQQRLLLEVSWEALERTGIDP MAV_3109|M.avium_104 CRCGGFLTGVGDFDAAFFGIAPSEALAMDPQQRLLLEVSWEALERAGIDP MUL_2266|M.ulcerans_Agy99 ASTGGFVDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDP MLBr_00135|M.leprae_Br4923 TRWGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDP MSMEG_4727|M.smegmatis_MC2_155 SKWGAFLDDPAAFDPEFFGITEREAAAIDPQHRLLLETAWEAVEHSGLNP TH_4621|M.thermoresistible__bu SRWGAFLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTP ..*: . **. ***:: *. :***:*::** :*.*:* :* * Mflv_0405|M.gilvum_PYR-GCK SELANTNTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRIS MAB_0939|M.abscessus_ATCC_1997 TDLAETNSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRIS Mvan_1003|M.vanbaalenii_PYR-1 SALAGTRTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRIS Mb1689|M.bovis_AF2122/97 ITLRGSQTGVFAGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA Rv1661|M.tuberculosis_H37Rv ITLRGSQTGVFAGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA MMAR_2471|M.marinum_M TTLRGSATGVFVGVFHGSYGGQG---RVPGDLERYGLRGSTLSVASGRVA MAV_3109|M.avium_104 ATLRGSATGVFAGIFHGSYGGQG---RVPGNLERYGLRGSTLSVASGRVA MUL_2266|M.ulcerans_Agy99 TGLRGSATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVA MLBr_00135|M.leprae_Br4923 LSLRGSATGVFTGIFAPSYGS-----RDTGGLQGYGLTGTAVSVASGRVS MSMEG_4727|M.smegmatis_MC2_155 AGLAGSATGVFMGLTHNDYAHLAA--DAKALEGPYGFTGTSFSLASGRIA TH_4621|M.thermoresistible__bu ADVEGSSTGVFVGLSHDDYALLTS--DAGALEEAYGFTGSAFSMASGRIA : : :*** *: .* * * : : * **:: Mflv_0405|M.gilvum_PYR-GCK YRLGLQGPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPA MAB_0939|M.abscessus_ATCC_1997 YRLGLQGPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPA Mvan_1003|M.vanbaalenii_PYR-1 YRLGLQGPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPA Mb1689|M.bovis_AF2122/97 YVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA Rv1661|M.tuberculosis_H37Rv YVLGLQGPAVSVDTACSSSLVALHLAVQSLRLGECDLALVGGVTVMATPA MMAR_2471|M.marinum_M YVLGLEGPAVSVDTACSSSLVALHLAVQSLRSRECDLALVGGVTVMATPA MAV_3109|M.avium_104 YALGLEGPAVSVDTACSSSLVALHLAAQSLRSGECDLALAGGVTVMATPA MUL_2266|M.ulcerans_Agy99 YVLGLEGPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPT MLBr_00135|M.leprae_Br4923 YVLGLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPS MSMEG_4727|M.smegmatis_MC2_155 YALGVHGPAITVDTACSSSLSAIHMACRSLHDGESDVALAGGVSVLLEPR TH_4621|M.thermoresistible__bu YRLGVHGPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPR * **:.**:::********* *:* * :*: *.*:**.**. * * Mflv_0405|M.gilvum_PYR-GCK TMITFSNAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDR MAB_0939|M.abscessus_ATCC_1997 TMITFSHAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDR Mvan_1003|M.vanbaalenii_PYR-1 TMINFSRARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDR Mb1689|M.bovis_AF2122/97 MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHP Rv1661|M.tuberculosis_H37Rv MFIEFSRQRALSADGRCKAYAGAADGTAFAEGAGVLVLARLADARRLGHP MMAR_2471|M.marinum_M MFIEFSRQRALSADGRCKAYAGAADGTAFSEGAGALVLERLTDAQRLGHP MAV_3109|M.avium_104 MFIEFSRQRALAADGRCKAYAGAADGTGFSEGVGVLVLERLSDARRLGHS MUL_2266|M.ulcerans_Agy99 VFVEFSRHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHP MLBr_00135|M.leprae_Br4923 IFVGFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHT MSMEG_4727|M.smegmatis_MC2_155 KAAGGSAAGMLSPTGHCHAFDTAADGFVSAEGCVVLTLKRLDDAVADGDR TH_4621|M.thermoresistible__bu KYTSASGLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDR * *:. *:.::: :*** .** : : ** ** .. Mflv_0405|M.gilvum_PYR-GCK IRAVIRGSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEA MAB_0939|M.abscessus_ATCC_1997 IRAVIRGSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEA Mvan_1003|M.vanbaalenii_PYR-1 IRAVIRGSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEA Mb1689|M.bovis_AF2122/97 VLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG Rv1661|M.tuberculosis_H37Rv VLALVRGSAVNQDGASNGLATPNGPAQQRVITAALASARLGVADVDVVEG MMAR_2471|M.marinum_M VLAVVRGSAVNQDGASNGLATPNGPSQQRVIRAALASARLGVADVDVVEG MAV_3109|M.avium_104 VLAVLRGSAVNQDGASNGLATPNGPSQQRVIRAALANARLGAADVDLVEG MUL_2266|M.ulcerans_Agy99 VLALVRGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEG MLBr_00135|M.leprae_Br4923 VLAVVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEA MSMEG_4727|M.smegmatis_MC2_155 ILAVIRGTATNQDGRTVNIATPSADAQAKVYRMALKAAGVEPGTVGLVEA TH_4621|M.thermoresistible__bu ILAVVRGTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEA : *::**:* **** : .::.*. :* * ** * : . *. :*. Mflv_0405|M.gilvum_PYR-GCK HGTGTSLGDPIEAQAAGAALGPG----REPQRPLLIGSAKTNIGHLEAAA MAB_0939|M.abscessus_ATCC_1997 HGTGTSLGDPIEAQAAGAAYGIG----RETNDPLLIGSAKTNIGHLEAAA Mvan_1003|M.vanbaalenii_PYR-1 HGTGTPLGDPIEVQAAGAVLGVG----REPDRPLLIGSVKTNIGHLEAAS Mb1689|M.bovis_AF2122/97 HGTGTTLGDPIEAQAILATYGQ-----RPADRPLWLGSIKSNIGHTSAAA Rv1661|M.tuberculosis_H37Rv HGTGTTLGDPIEAQAILATYGQ-----RPADRPLWLGSIKSNIGHTSAAA MMAR_2471|M.marinum_M HGTGTTLGDPIEAQAILATYGQDR--TGPGKEPLWLGSIKSNMGHTSAAA MAV_3109|M.avium_104 HGTGTMLGDPIEAQALLATYGQD----RPVDEPLWLGSIKSNMGHTSAAA MUL_2266|M.ulcerans_Agy99 HGTGTTLGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAA MLBr_00135|M.leprae_Br4923 HGTATTLGDPIEAQALLATYGQG----RPADQPLWVGSIKSNMGHTQAAA MSMEG_4727|M.smegmatis_MC2_155 HGTGTPVGDPLEFSSLAEVYGTDG--------PCALGSIKTNFGHTQSAA TH_4621|M.thermoresistible__bu HGTGTPVGDPIEYNSLTQVYGKTG--------PCALTSVKTNFGHAESAA ***.* :***:* .: . * . : * *:*:** .:*: Mflv_0405|M.gilvum_PYR-GCK GIAGVIKVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQ MAB_0939|M.abscessus_ATCC_1997 GIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR-- Mvan_1003|M.vanbaalenii_PYR-1 GIAGLLKVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR-- Mb1689|M.bovis_AF2122/97 GVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP- Rv1661|M.tuberculosis_H37Rv GVAGVIKMVQAMRHGVLPKTLHVDVPTPHVDWSAGAVSLLTEPRPWHVP- MMAR_2471|M.marinum_M GVAGVIKMTLAMQHGVLPQTLHVDVPTPHVDWSAGSVSLLTEARPWPET- MAV_3109|M.avium_104 GAGGVIKMVQAIRHGVMPKTLHVDEPTPQVDWSAGAVSLLTEARPWPAR- MUL_2266|M.ulcerans_Agy99 GVAGVIKMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAES MLBr_00135|M.leprae_Br4923 GVAGVIKMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWSVE- MSMEG_4727|M.smegmatis_MC2_155 GALGVMKAVLALQHNVIPQNLHFTRLPDQMAEIETGLFVPETITPWPVR- TH_4621|M.thermoresistible__bu GALGMMKAILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVR- * *::* ::.: :* :. . .: : : * Mflv_0405|M.gilvum_PYR-GCK RGGRPRIAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLP MAB_0939|M.abscessus_ATCC_1997 -NGRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILP Mvan_1003|M.vanbaalenii_PYR-1 -SGRSRVAGISSFGFSGTNAHVLVEEAPRADRAGAAPQPAAPGG-FGMLP Mb1689|M.bovis_AF2122/97 --GRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDP--VAVPWV- Rv1661|M.tuberculosis_H37Rv --GRPRRAGVSSFGISGTNAHVILEEAPAVEPVGAAHGNDP--VAVPWV- MMAR_2471|M.marinum_M --GRARRAGISSFGISGTNAHVILEQAPAAEEVAAQHRTD----LTPWI- MAV_3109|M.avium_104 --DRPRRAGVSSFGISGTNAHVIVEQY---EPETVAPQGGD--VVVPWV- MUL_2266|M.ulcerans_Agy99 AGDRVRRAGVSSFGISGTNAHVIVEAAPRVEVGGSS-GGAV--PVVPWV- MLBr_00135|M.leprae_Br4923 --GRPRRAGVSSFGISGTNAHVILEEAPTPVEASYSTADQQRLSVVPWV- MSMEG_4727|M.smegmatis_MC2_155 -EGQPRRAAVSAYGLSGTNVHAVLEQAPESPAETAAEAISPKAGNALVFP TH_4621|M.thermoresistible__bu -EGCPRRAAVSSYGMSGTNVHAVLEQAP-EPVQRPEESADTDAAGPLVFA . * *.:*::*::***.*.::* . Mflv_0405|M.gilvum_PYR-GCK LSARTPAALMAVADRYRDWLVANPD-------ATLADLCFTAGTARSHLE MAB_0939|M.abscessus_ATCC_1997 LSARTPAALAQLADKYRAWLNAHPE-------AALADLCFTAGVGRAHLE Mvan_1003|M.vanbaalenii_PYR-1 LSARTPDALAATAHRLRTWLAANPD-------ASWPDLCFTAAVGRSHLR Mb1689|M.bovis_AF2122/97 LSARSAQALTNQARRLLAWVGADEN-------VRPLDVGWSLVNTRSLFD Rv1661|M.tuberculosis_H37Rv LSARSAQALTNQARRLLAWVGADEN-------VRPLDVGWSLVNTRSLFD MMAR_2471|M.marinum_M LAARSAPALVNQARRLAQWVSDRPD-------LDVADVGWSLATTRSVFE MAV_3109|M.avium_104 LSARSAEALTNQAARLLARVKADPG-------VRVLDVGWSLVSTRSRFE MUL_2266|M.ulcerans_Agy99 VSAKSGSALGAQAARLAAHVRSHDE-------LDVADVGWSLAG-RSTFE MLBr_00135|M.leprae_Br4923 VSGRSTAALMAQASRLAFYVQADPE-------VDPVDVGCALAA-RSVFE MSMEG_4727|M.smegmatis_MC2_155 VSASSADALRSTAQHLADWLLRSGDGNGRGPAIDLGDLAYTLARRRGFRA TH_4621|M.thermoresistible__bu LSSTSAEELRRTAGRLAEWVEAHTD------EVVPADLAYTLARRRAHRP ::. : * * : : *: : *. Mflv_0405|M.gilvum_PYR-GCK HRAALVVNTREAALDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGS MAB_0939|M.abscessus_ATCC_1997 HRAALVVNTREAAVELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGS Mvan_1003|M.vanbaalenii_PYR-1 HRAALVVDSRSSVEELLGALAEDRPG-PGLARGECGDPPKTAWLFTGQGS Mb1689|M.bovis_AF2122/97 HRAVVVGADRTQLMEGLTGLAAGVPG-ADVVAGRAQTVGKTAFVFPGQGA Rv1661|M.tuberculosis_H37Rv HRAVVVGADRTQLMEGLTGLAAGVPG-ADVVAGRAQTVGKTAFVFPGQGA MMAR_2471|M.marinum_M HRAVVVGADRTQLIQGLAGFVDGEPR-AGVVVGRARPVGKTVFVFPGQGS MAV_3109|M.avium_104 HRAVIVGADGAQLLRRLADLAGGQPG-AGVVTGRAQPVGKTVFVFPGQGS MUL_2266|M.ulcerans_Agy99 HRAVVLGADRDGLLAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGS MLBr_00135|M.leprae_Br4923 HRAVVVGESREQLIAGLAGLAVGESG-AGVAIGQAAPLGKTVVVFPGQGA MSMEG_4727|M.smegmatis_MC2_155 ARSAVLAGDRGTLVEGLRQIADGEAM---PQQAVTNDDRGPVWVFSGQGS TH_4621|M.thermoresistible__bu VRTTVIADGVEALTAGLREVADGDAP---YQPAVGMDDKAPVWVFSGQGS *:.:: * .. . . .. :*.***: Mflv_0405|M.gilvum_PYR-GCK QYPGMSRELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDS MAB_0939|M.abscessus_ATCC_1997 QYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEA Mvan_1003|M.vanbaalenii_PYR-1 QYPGMGRELFDTEPVYREVMTRCAEAVADVLERPLLDVVFDAD------G Mb1689|M.bovis_AF2122/97 QWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAP------G Rv1661|M.tuberculosis_H37Rv QWLGMGAQLCATAPVFAEHIHRCERALREHVEWSLLDVLRGAP------G MMAR_2471|M.marinum_M QWVGMGVDLLDTSTVFADQMHRCEKALAEYVSWSLLDVVRAVP------G MAV_3109|M.avium_104 QWPGMGAQLLDRSTVFAEHMHRCARALAEHVDWSLIDVIRGAP------G MUL_2266|M.ulcerans_Agy99 QWIGMGIELLDTAPVFARHIESCGQAFAEFVDWSLLDVLRGAA------G MLBr_00135|M.leprae_Br4923 QRIGMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGAD------A MSMEG_4727|M.smegmatis_MC2_155 QWASMGAELLDREPAFAAAIAELEPLIAAESDFSVTEALTASET------ TH_4621|M.thermoresistible__bu QWAGMGAELLATEQVFAAKIAEIEPLVARESGFSVTEAMTASET------ * .*. :* : : . .: :.: Mflv_0405|M.gilvum_PYR-GCK NETLRHTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAG MAB_0939|M.abscessus_ATCC_1997 EETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAE Mvan_1003|M.vanbaalenii_PYR-1 GEALRHTSYAQPALYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAG Mb1689|M.bovis_AF2122/97 APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAG Rv1661|M.tuberculosis_H37Rv APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAAYVAG MMAR_2471|M.marinum_M APGLNRVDVVQPVLWAIMVSLAELWRSAGVLPDAVIGHSQGEIAAAYVAG MAV_3109|M.avium_104 APGLDRVDVVQPALWAVMVSLAELWRSVGVVPDAVIGHSQGEIAAACVAG MUL_2266|M.ulcerans_Agy99 APGLDRIDVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAG MLBr_00135|M.leprae_Br4923 G-LLDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAG MSMEG_4727|M.smegmatis_MC2_155 ---VTGIDRVQPTIFAVQVALAAAMRSHGVVPGAVIGHSMGEVAASVVSG TH_4621|M.thermoresistible__bu ---VTGIDRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAG : . .**.::*: :.* : *. *. *:*** *: :*: *: Mflv_0405|M.gilvum_PYR-GCK VLSLRDGARLMAERGRLFGSLPSGGRMAAVFAAAERV-EALTDEY-PALS MAB_0939|M.abscessus_ATCC_1997 VFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERA-ERLTDEF-PSLS Mvan_1003|M.vanbaalenii_PYR-1 VMGLEDGAVLLAERGRLFGSLPEGGRMAAVFAPADRV-ESCTVDS-PLLS Mb1689|M.bovis_AF2122/97 ALSLWDAAAVVALRSRLLVRLGGAGGMVSLACGQPQA-EKLASQWGDRLN Rv1661|M.tuberculosis_H37Rv ALSLRDAAAVVALRSRLLVRLGGAGGMVSLACGQPQA-EKLASQWGDRLN MMAR_2471|M.marinum_M ALSLEDAARVVARRSQLLVQLSGAGGMVSLACGLERA-RQLVASWSDRLS MAV_3109|M.avium_104 ALSLHDAARVVALRSRLLVRLSGRGGMVSLACGRSRA-EQLIAPWGERLN MUL_2266|M.ulcerans_Agy99 ALSLRDAAKVVTLRSKLLVGLAGPGGMVSVACGEQQA-RELLEPFGDRVS MLBr_00135|M.leprae_Br4923 VLAPADAAMLVVARGRLMQSMPAGGTMWAVAASE----DEVVSLLGEGVG MSMEG_4727|M.smegmatis_MC2_155 ALSLEDGVKVICRRTRLMTRIAGSGAMAMVELPAQQVLSELASRGVDDVV TH_4621|M.thermoresistible__bu ALSLEDGVKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVV .:. *.. :: * :* : * * : : Mflv_0405|M.gilvum_PYR-GCK VAAYNG-ANTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDPI MAB_0939|M.abscessus_ATCC_1997 VAAYNG-ANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPI Mvan_1003|M.vanbaalenii_PYR-1 VAAYNG-DNTVLSGPAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPV Mb1689|M.bovis_AF2122/97 IAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAI Rv1661|M.tuberculosis_H37Rv IAAVNGVSSVVLAGETDAVTELMQRCEAEGIRARRIDVDYASHSAQVDAI MMAR_2471|M.marinum_M IAAVNGVSAIVVSGEVDALDALIGRCEADDIRARRIDVDYASHSAQVEAI MAV_3109|M.avium_104 IATVNGISAVVVSGEVDALTELLDRCAADDIRARRIDVDYASHSVQVEEI MUL_2266|M.ulcerans_Agy99 IAAINGPSAVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAI MLBr_00135|M.leprae_Br4923 IAAINAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPM MSMEG_4727|M.smegmatis_MC2_155 LSVVASPQSTVVGGATASVRELIEMWESRGVMAREIAVDVASHSPQVDPI TH_4621|M.thermoresistible__bu LSVIASPESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPI ::. . *:.* : : .. * ** :: : Mflv_0405|M.gilvum_PYR-GCK LDDFESYARGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEF MAB_0939|M.abscessus_ATCC_1997 LDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEF Mvan_1003|M.vanbaalenii_PYR-1 LEEFESCADRFEFGTPQRTLVCNRSGEVLSRHARLDGQYWRRHARQPVRF Mb1689|M.bovis_AF2122/97 REELIAALRGIEPRTSTVAFFSTVTG-ELMDTAGVNAEYWYRSIRQPVQF Rv1661|M.tuberculosis_H37Rv REELIAALRGIEPRTSTVAFFSTVTG-ELMDTAGVNAEYWYRSIRQPVQF MMAR_2471|M.marinum_M RAELAEALDGIAPQSTSTAFISTVTG-EFTDTAGLDADYWHRSIRQTVQF MAV_3109|M.avium_104 RDSLAEALRGIAPRSSAVAFFSTVTG-ELMDTAALDGDYWFRSIRQTVQF MUL_2266|M.ulcerans_Agy99 EGQLTEVLAGIEPLSSRTAFFSSVTG-SRLDTAELDAEYWYRNIRQTVQF MLBr_00135|M.leprae_Br4923 LEEFVRVAAQVEVRKPQIGLVSNVTG-ELAGPDFGSPQYWGEHVSRAVRF MSMEG_4727|M.smegmatis_MC2_155 LDDLIEALADLDPAEPEIPYYS-ATLYDPRDYADYDAYYWADNLRHTVRF TH_4621|M.thermoresistible__bu LDELEEILADLQPMTPTVPYYS-ATSYDPREKPVCDADYWVDNLRHEVRF .: . . : . ** : *.* Mflv_0405|M.gilvum_PYR-GCK AKSVHTLADMNCKLLVEIGPRPVLTAAALSAWPD----PATSPRVIASLR MAB_0939|M.abscessus_ATCC_1997 AKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPD----PATAPRAIASLR Mvan_1003|M.vanbaalenii_PYR-1 AESVRTLADLGCRLLMEIGPQPVLTAAAMRTWPG----TVTAPRVAASMR Mb1689|M.bovis_AF2122/97 ERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLG Rv1661|M.tuberculosis_H37Rv ERAVRNAFDGGYRVFVESSPHPVLIAGIEETLVDCDRGATGEPIVIPTLG MMAR_2471|M.marinum_M ERAIRTAFNSGCQVFIESSPHPVLMAGIEETLAGQQD--SGEAIVIPSLG MAV_3109|M.avium_104 ERAVRGAAEAGYRAFIECSPHPVLTAAIEETMP-----DGGQGCVIPSLG MUL_2266|M.ulcerans_Agy99 DQAVRSACGHGYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLG MLBr_00135|M.leprae_Br4923 VDSARHLQTLGATHFIESGPSSGLMGAIEQSLAP------AEAVVVSMMG MSMEG_4727|M.smegmatis_MC2_155 SAAVQAALEDGHRVFAELSPHPLLTHPVEQTARS----LDMPLAVFAAMR TH_4621|M.thermoresistible__bu AAAVQAALEDGFRVFGELSPHPLLTRAVEQTARG----LDMPVAALPAMR : : . : * .* . * : . . : Mflv_0405|M.gilvum_PYR-GCK RTTADQRQITEAVADAYVLGHLPRFAAFRRD-GARVLDLPTYPFEHRQYW MAB_0939|M.abscessus_ATCC_1997 RNTADHRQITEAAADAYVLGHLPDFGAFQHA-PARKLDLPTYPFERRQYW Mvan_1003|M.vanbaalenii_PYR-1 RKGSDRRQITEALAQAYVAGHRPETAARQHG-RGRLLDLPTYPFQHRAYW Mb1689|M.bovis_AF2122/97 RDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFW Rv1661|M.tuberculosis_H37Rv RDDGGVGRFWLSAGQAHVAGVGVDWRAAFADLGGRRVELPTYAFARQRFW MMAR_2471|M.marinum_M RDDGGLQRFWLSVAQAHVAGVRVDWASIIG--AGRRVALPTYGFQHRRFW MAV_3109|M.avium_104 RDDGGPDRFWLSAGQAFVSGVVVDWCAMLDGLGGRRVDLPTYGFVRQHFW MUL_2266|M.ulcerans_Agy99 REDGGLQRFLASAAAAFVAGVNVDWRGPLD--GAGLVELPTYAFEKRRFW MLBr_00135|M.leprae_Br4923 KDRPELASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFW MSMEG_4727|M.smegmatis_MC2_155 RQQEMPHGLLGFVADLHSAGAAVDFSVLYPT--GRLLDAPLPAWTHSTLL TH_4621|M.thermoresistible__bu REQEMPHGVRTMVGDLFAAGAAVDFAALYPS--GRLVDAPLPTWTRRKLV : . . . * : * : : Mflv_0405|M.gilvum_PYR-GCK FSDSRE---PVAAAPQR---GARTETVRLLEDGRIEELAALLGGTVDDPF MAB_0939|M.abscessus_ATCC_1997 FSDKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQ Mvan_1003|M.vanbaalenii_PYR-1 FPQGQARTAPTDP--------VHTETVRFLDEERIDELAALLDGPTGSAQ Mb1689|M.bovis_AF2122/97 LDGLGAVGGDLGG------------------VGLVGAEHGLLAAVVQRPD Rv1661|M.tuberculosis_H37Rv LDGLGAVGGDLGG------------------VGLVGAEHGLLAAVVQRPD MMAR_2471|M.marinum_M LGQLDAGRTDVGG------------------LGQAGAAHGLLGAVVERPD MAV_3109|M.avium_104 LPGGSTGSSDVAA------------------LGLRGAEHGLLGAVLPRPD MUL_2266|M.ulcerans_Agy99 LSG-EGVSVDASG------------------LGLSAGGHALLGAVVELPE MLBr_00135|M.leprae_Br4923 ETPGTDGTASVSG------------------LGLGSTEHALLGAVVERPD MSMEG_4727|M.smegmatis_MC2_155 LDREL-ESSAPGV--------------------PSVSVHPLLGSHVVLPQ TH_4621|M.thermoresistible__bu LSRENGEQQTRGG--------------------CTITVHPLLGTHVRLPE ** Mflv_0405|M.gilvum_PYR-GCK TFDVLNRLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLL MAB_0939|M.abscessus_ATCC_1997 TLNVLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLL Mvan_1003|M.vanbaalenii_PYR-1 TVDVLSKLAARHRQQRGAQSIADARYQIRWEKSEAPGAARPTTEATTWLL Mb1689|M.bovis_AF2122/97 SGGVVLTG--------------------RISVVAAPWLADHAVGPVVLFP Rv1661|M.tuberculosis_H37Rv SGGVVLTG--------------------RISVVAAPWLADHAVGPVVLFP MMAR_2471|M.marinum_M SGGVVLTG--------------------QLSVALQPWLAGHAVAGTVLFP MAV_3109|M.avium_104 SGGVVLTG--------------------RLSTSAQAWLADHAVGDTVLFP MUL_2266|M.ulcerans_Agy99 SGGVVLTG--------------------RLALGAHGWLADHAVSGVVVFP MLBr_00135|M.leprae_Br4923 SGGVVLTG--------------------RLSLANQPWLADHVIGGVVLFP MSMEG_4727|M.smegmatis_MC2_155 EPEEHLWQG-------------------DVGTEAHPWLSDHRVHQVAVLP TH_4621|M.thermoresistible__bu EPERHVWQA-------------------DLGTGAQPWLADHQIHTVAALP . . : Mflv_0405|M.gilvum_PYR-GCK VGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADATD MAB_0939|M.abscessus_ATCC_1997 VADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSA Mvan_1003|M.vanbaalenii_PYR-1 VTHDSRAAQPIAEVLERRGHPYHIVGLPGSDADAAPAEEALRATVSQ-PR Mb1689|M.bovis_AF2122/97 GTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSG Rv1661|M.tuberculosis_H37Rv GTGFVELALRAGDEVGCSVLQELTLQAPLVLPADG-VRVQVVVGGVEQSG MMAR_2471|M.marinum_M GAGFVELAIRAGDEVGCAAVEELTLSAPLVLPTVGGVQLQVVVGPADQSD MAV_3109|M.avium_104 GAGFVELAIRAGDEVGCGVIDELTLSAPLPLPASGGVRLQLVVGAPDEAG MUL_2266|M.ulcerans_Agy99 GTGFVELAIRAVDEVGCSVVNELTLRTPLVLPASGSVAVQVVVGAAADSA MLBr_00135|M.leprae_Br4923 GAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAADESS MSMEG_4727|M.smegmatis_MC2_155 GAAYCEMALAAVTPVLG-DTGEVHDLKFHDMLLLDDATPVWVSAAVTAPG TH_4621|M.thermoresistible__bu GAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAVASAVEPG . : . Mflv_0405|M.gilvum_PYR-GCK LRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMWL MAB_0939|M.abscessus_ATCC_1997 LRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWI Mvan_1003|M.vanbaalenii_PYR-1 PHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQLAATAGARAPIWL Mb1689|M.bovis_AF2122/97 TRNVWVYSAAG--------QADSSPGWTLHAQGVLGVGSVQPAAELSVWP Rv1661|M.tuberculosis_H37Rv TRNVWVYSAAG--------QADSSPGWTLHAQGVLGVGSVQPAAELSVWP MMAR_2471|M.marinum_M HRTVEVYSRGD--------QSLS--EWSLHAEGVLAPAAVASVGQLTAWP MAV_3109|M.avium_104 RRPLSVYSAAA--------HQDS--EWMLHAEGVLRTGTVTPAGDLSIWP MUL_2266|M.ulcerans_Agy99 ERSVSIYSRTDTDT-----DTDAGSVWVCHAEGTLGADSAQPAADLSAWP MLBr_00135|M.leprae_Br4923 RRAVSVYSRGD----------QSHGGWLLNAEGLLEVDAAEATVDLSLWP MSMEG_4727|M.smegmatis_MC2_155 TAEFGVETHQS-----------GDRTQRATAVLRGDVDAERPAAHSIDAL TH_4621|M.thermoresistible__bu TLEFAVETAKD-----------GEHERRATAVLGAADDTEPPQAHDIDAL . : : . : . Mflv_0405|M.gilvum_PYR-GCK VTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGT---S MAB_0939|M.abscessus_ATCC_1997 VTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAG---T Mvan_1003|M.vanbaalenii_PYR-1 ITAGAQRITGDETVEPAQTSLWGFGRAAALEQPELWGGLADVTTGD---A Mb1689|M.bovis_AF2122/97 PV-GARAMDVADGYQVLAARGYGYG--------PAFRGLQALWRRG---A Rv1661|M.tuberculosis_H37Rv PV-GARAMDVADGYQVLAARGYGYG--------PAFRGLQALWRRG---A MMAR_2471|M.marinum_M PE-GATALDLGGVYDRLAARGYEYG--------PAFRGLQAVWESG---D MAV_3109|M.avium_104 PI-GATAVDVTGGYARLAQRGYEYG--------RAFRGLRAMWQRG---D MUL_2266|M.ulcerans_Agy99 PA-GAIAVDVADGYERLDARGYGYG--------PAFRGLTAMWARG---E MLBr_00135|M.leprae_Br4923 PE-GAESVDISDAYPQLAERGYAYG--------PAFQGLVAIWRRG---S MSMEG_4727|M.smegmatis_MC2_155 LAAHPNRVDGDELRAGFGTVGIGHG--------AAFAGLSEAYVATAAEP TH_4621|M.thermoresistible__bu LAEHPTRIEGDELRQWFDQRGVQFG--------PAFTGLTAARIPEGTVT . : .* : ** Mflv_0405|M.gilvum_PYR-GCK DEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDT-LPSGKPLHL MAB_0939|M.abscessus_ATCC_1997 DEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREE-LPSGKPLEV Mvan_1003|M.vanbaalenii_PYR-1 EEWSALIDHIVA---APTSEDQIAVRGREIHVARLTRCAE-KANAAALEL Mb1689|M.bovis_AF2122/97 EVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEG----EQQTMLPF Rv1661|M.tuberculosis_H37Rv EVFADVTLPE--GVPIRGFGIHPAVLDAALHAWGIVEG----EQQTMLPF MMAR_2471|M.marinum_M EIFAEVALPEDAGAQIGGFGIHPALLDAALHALVLTAE----QNQTVLPF MAV_3109|M.avium_104 EIFAEVALPDD-AAAGDDFGVHPVLLDAALHALGVAGE----KDQTVLPF MUL_2266|M.ulcerans_Agy99 ELFAEARLPEA-AGSTSGFGVHPALLDAALHTAVIANP----DADLVLPF MLBr_00135|M.leprae_Br4923 ELFAEVVAPTG--VVVDGMGMHPALLDAVLHALGLAIENTQATTEMRLPF MSMEG_4727|M.smegmatis_MC2_155 TVVAAVALPGPLRSGQRGYTVHPALLDACFQSVIAHPEVQNIASGMLLPL TH_4621|M.thermoresistible__bu SVLAEVGLPGQIRSQQAPYGIHPALLDACFQSVAAHPDVQGAGSGLLLPL : : .: . * . Mflv_0405|M.gilvum_PYR-GCK RADATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRTPDEAAASRIEAL MAB_0939|M.abscessus_ATCC_1997 RSDATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDAL Mvan_1003|M.vanbaalenii_PYR-1 RREATYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRSASDTVRQRIDAM Mb1689|M.bovis_AF2122/97 SWQGVCLHASGAARVRVRLAP----VGRGAVPVELADPQGLPVLSVRQLM Rv1661|M.tuberculosis_H37Rv SWQGVCLHASGAARVRVRLAP----VGRGAVSVELADPQGLPVLSVRQLM MMAR_2471|M.marinum_M AWQGVSLHAAGASRCRVRIAQ----SRSGSVAMELADSAGLPVLTVRDLA MAV_3109|M.avium_104 SWQGVALHASGASRARVRIAP----AGAGAVSVELADGAGLPVLSVRSVT MUL_2266|M.ulcerans_Agy99 SWQGVSLHAAGAASVRVRIAP----VGPSSVSVELADDLGLPVLSVKAMV MLBr_00135|M.leprae_Br4923 CWRGVSLHAGGAGRVRARFTS----AGADAIAVDIADSAGLPVLTVRSLV MSMEG_4727|M.smegmatis_MC2_155 GVRRLRAYGSTRNVRYCLSRIVKADSFGVEADLELLDADGTVLLSAMGLQ TH_4621|M.thermoresistible__bu GVRRLQAFGPTRGARYCYARVTDADGSKAEADLDVLDEHGNVLLRVQGLL : . Mflv_0405|M.gilvum_PYR-GCK RERHGCEV------------------------------------------ MAB_0939|M.abscessus_ATCC_1997 AA-QGCEV------------------------------------------ Mvan_1003|M.vanbaalenii_PYR-1 RERFDCQV------------------------------------------ Mb1689|M.bovis_AF2122/97 VRPVSAAA------------------------------------------ Rv1661|M.tuberculosis_H37Rv VRPVSAAA------------------------------------------ MMAR_2471|M.marinum_M FRPVSDQT------------------------------------------ MAV_3109|M.avium_104 MRPVSPGQ------------------------------------------ MUL_2266|M.ulcerans_Agy99 ARPVSEQQ------------------------------------------ MLBr_00135|M.leprae_Br4923 TRAMTAEQ------------------------------------------ MSMEG_4727|M.smegmatis_MC2_155 LGTGNSDKAEEERLLDERLLTIEWQQRELPRPEGSETVDAGSWLVILAGD TH_4621|M.thermoresistible__bu MGGAAADGDDRDRVLGERLLTIEWQRRDLPEADS----AAGKWLLVSTS- Mflv_0405|M.gilvum_PYR-GCK -----RVVTADVADAHAVARLLATVQAEMPPLAGIVHAAG---------- MAB_0939|M.abscessus_ATCC_1997 -----RAVTADVADGHDVARLLAGIQAELPPLAGIVHAAG---------- Mvan_1003|M.vanbaalenii_PYR-1 -----LVATADVADRDDVARLFSTMRSELPPLAGIVHAAG---------- Mb1689|M.bovis_AF2122/97 -----LSR--STAGD---RGLLEMIWTPVPLEGGDIGDD----------- Rv1661|M.tuberculosis_H37Rv -----LSR--STAGD---RGLLEMIWTPVPLEGGDIGDD----------- MMAR_2471|M.marinum_M -----SSA--GTAGG---GGLLEVVWSPLARPGDDTADIP---------- MAV_3109|M.avium_104 -----LSAAMGTAQP---SGLLDVIWSPIALGGNDLGDE----------- MUL_2266|M.ulcerans_Agy99 -----MRAVVSASGP---DRLFEVVWTPMTVAATDAAPAY---------- MLBr_00135|M.leprae_Br4923 -----LRTAVTAAGGALEQGPMDLVWSPIPLSSDGHGGGLPSVVSWADYC MSMEG_4727|M.smegmatis_MC2_155 DDENPRAAGVVSALIGAGMPTTTMAWSHDADHDAQAAALTAR------LD TH_4621|M.thermoresistible__bu ATADVSATRLSDALKQAGAESTSMCWPQQADHADNVDRFRAG------IA : . . Mflv_0405|M.gilvum_PYR-GCK --------EIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDLQLDFFI MAB_0939|M.abscessus_ATCC_1997 --------EIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGLKLDFFI Mvan_1003|M.vanbaalenii_PYR-1 --------EIGTSPLRTLDDAEMDRVFAGKVWGAVYLCEEVADMGLDFFL Mb1689|M.bovis_AF2122/97 --------AVVWELPPHAG-AQAGGDVLAAVYRGVHEVLEVLQSWLASDA Rv1661|M.tuberculosis_H37Rv --------AVVWELPPHAG-AQAGGDVLAAVYRGVHEVLEVLQSWLASDA MMAR_2471|M.marinum_M --------VTLWDLASQVE-LSAG--AVESTYVATHGALGALQSWLASDQ MAV_3109|M.avium_104 --------VTLWEPG------EHGGDVVKSVHAAVTETLAVLQSWLDGEG MUL_2266|M.ulcerans_Agy99 --------ELFESIA-------ADGDPLSGTYQRTHQALAAVQSWLTEHD MLBr_00135|M.leprae_Br4923 AGRGNDTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFGQDR MSMEG_4727|M.smegmatis_MC2_155 EQPLAGVAVIVGDSETGTDAHDVGADARRGADHVRHLVRIARTLADAVGE TH_4621|M.thermoresistible__bu DG-VTGVVVLTGPKNGNPDD----AAARRGSDYVRHLVRITRELAEIDGD . Mflv_0405|M.gilvum_PYR-GCK STSSIASVWGGFGQAAYGAANAFLDGLAWRLREQGVAGVSV--NFGPWSA MAB_0939|M.abscessus_ATCC_1997 NTSSIAAVWGGYGQTAYSAANAFLDGLAWRLREQGIAGTSV--NFGPWSA Mvan_1003|M.vanbaalenii_PYR-1 ATSSIASVWGSHGQTAYGAANAFLDGLADSLRARGIPGISV--NFGPWAA Mb1689|M.bovis_AF2122/97 TGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGR--VVLVDTD Rv1661|M.tuberculosis_H37Rv TGLGVVVTRGAVGPVDDDVTDLAGAAVWGLVRSAQAEHPGR--VVLVDTD MMAR_2471|M.marinum_M PGVLAVVTHGAVGLADEDVTDLAGSAVWGLVRSAQAEHPGR--VVLVDTD MAV_3109|M.avium_104 AGVLAVQTHGAVALAGEDVSDLAGAAVWGLVRSAQAEHPGR--LVLIDSD MUL_2266|M.ulcerans_Agy99 SGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQTENPGR--LVLVDSD MLBr_00135|M.leprae_Br4923 AGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHSGK--IVLIDTD MSMEG_4727|M.smegmatis_MC2_155 PPRLYVVTHRSQHVLDTDEPYLEHSGLRGLIRVVGMEHPRLRATQIDVDD TH_4621|M.thermoresistible__bu APRLFVVTRGAQAVLPQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIAD . . . . . .: :* Mflv_0405|M.gilvum_PYR-GCK GMADAQSRAR-LEQRGIKTLSPADALAGLSDAVISAAP-----HPVVARV MAB_0939|M.abscessus_ATCC_1997 GMADAESRAR-LEQRGIKTLSPTDALAGLADVVAASGSN--AVQGVIARI Mvan_1003|M.vanbaalenii_PYR-1 GMADAKAREQ-LSRRGVKTLAPADALAGMADVIAASTA-----HAVVARI Mb1689|M.bovis_AF2122/97 GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG---LTLPSASAG Rv1661|M.tuberculosis_H37Rv GSVAVEDAVGFGARSGEPQLVVRRGRVYAARLAPVAAG---LTLPSASAG MMAR_2471|M.marinum_M GSVELGAVL----NSGEPQLVVRAGVAYQARLKPAESL---LRLPPPGEN MAV_3109|M.avium_104 GSLDARAVIP----CGEPQVVVRQGVAHAARLRPARAG---ATLG-LPSG MUL_2266|M.ulcerans_Agy99 AAVDAAAVAT-ALAVGEPQVVLRNGQPYTARVHASRAAD--GILVPPVDG MLBr_00135|M.leprae_Br4923 SAVDVAVLAD----LGESQLLVRCNTVHAARLSPAPQL----LALPVGES MSMEG_4727|M.smegmatis_MC2_155 STAHEALVRQLLSGSPEDETAWRDGQWYAARLCPSPLRAAERRTAVADNA TH_4621|M.thermoresistible__bu DADLDRVAVQLLGGGAEDETAWRDGQWYTARLSLSPLRPEERKQAVVDCE : Mflv_0405|M.gilvum_PYR-GCK DWSRFLPLYQQAGRRGFLAELERELPAAPAQQGPAVTASGRTPLVERLTT MAB_0939|M.abscessus_ATCC_1997 DWARFLPLYQQAGKRGFLAELDREVPSHLA--GVAGAQSGSTQLVERLAN Mvan_1003|M.vanbaalenii_PYR-1 DWATFLPVYQLQRRRAFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTL Mb1689|M.bovis_AF2122/97 GWRLVAGGGGTLADVVVAPVAPV--ELATGQVRVAVGAVGVNFRDVLVAL Rv1661|M.tuberculosis_H37Rv GWRLVAGGGGTLADVVVAPVAPV--ELATGQVRVAVGAVGVNFRDVLVAL MMAR_2471|M.marinum_M -WRLVTGGGGTLDDVKVGGCAPS--GLMTGQLRVAVAAVGVNFRDVLVAL MAV_3109|M.avium_104 AWRLDAGGEGTLGDLVVSRCPRT--ELADGQVRVAVAAVGVNFRDVLVAL MUL_2266|M.ulcerans_Agy99 PWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAANFRDIMITL MLBr_00135|M.leprae_Br4923 MWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAAL MSMEG_4727|M.smegmatis_MC2_155 SEGMRLVVRNPGDLESMELVTFERGTPGPGQIEVAVKASSINFADVLVAF TH_4621|M.thermoresistible__bu RDGMRLEIRTPGDLETMELAAFDRVPPGPGQIEVAVTASSINFADVLIAF . * . . : Mflv_0405|M.gilvum_PYR-GCK APLQ---QRKRLLTDYLRDAVAEVTRVDAAEIREDAGFFDLGM-DSLMAV MAB_0939|M.abscessus_ATCC_1997 APVQ---QRKKLLTDYLRDAVAEVTRVDVSEIREDAGFFDLGM-DSLMAV Mvan_1003|M.vanbaalenii_PYR-1 APVE---QRRKLVLEYLRAAVAEVTRVDAAEIRDEAGFFDLGM-DSLMAI Mb1689|M.bovis_AF2122/97 GMYP---GGGE-LGVDGAGVVVEVGPGVTGLAVGDRVMGLLG--LVGSEA Rv1661|M.tuberculosis_H37Rv GMYP---GGGE-LGVDGAGVVVEVGPGVTGLAVGDRVMGLLG--LVGSEA MMAR_2471|M.marinum_M GMYP---GGGE-LGVEGAGIVTEVGPGVSGVAVGDAVMGLLG--VVGPEA MAV_3109|M.avium_104 GMYP---GGGR-LGAEGAGVVVEVGPAVTGLAVGDPVMGLLG--VVGSEA MUL_2266|M.ulcerans_Agy99 GMFT---HDAL-IGGEGAGVVVEIGPEVTEFAVGDAVYGFFPD-GSGTLV MLBr_00135|M.leprae_Br4923 GMYP---GQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLG--GAGPLA MSMEG_4727|M.smegmatis_MC2_155 GRCPSFDGRLPELGSEFGGVVTAVGPGVTTHRVGDRVGGVSANGCWSNFV TH_4621|M.thermoresistible__bu GRYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVGDRVGGLSPNGCWSTFV . : * : : Mflv_0405|M.gilvum_PYR-GCK ELRRRIETGVGKEIPVTLVMDHPRLSDAADYLLGDVLGLTEAAT-APKAA MAB_0939|M.abscessus_ATCC_1997 ELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVLGLAEQAKPAAQLA Mvan_1003|M.vanbaalenii_PYR-1 ELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVLGDVLGLSEHTVAQPDTP Mb1689|M.bovis_AF2122/97 VVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAG Rv1661|M.tuberculosis_H37Rv VVDARLVTMVPAGWSLVEAAAVPVAFLTAFYGLSVLAEVAAGQKVLVHAG MMAR_2471|M.marinum_M VVDHRLVTAVPPGWSLQTAASVPVVFLTAFYGLRVLAEVRSGQKLLVHAA MAV_3109|M.avium_104 VVDQRLLTAVPPGLSLVAAAGVPVVFLTALYGLSVLSGLRPGERVLVHTA MUL_2266|M.ulcerans_Agy99 AGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVLVHAA MLBr_00135|M.leprae_Br4923 VVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAG MSMEG_4727|M.smegmatis_MC2_155 TCEADLATKLPEGISEHEAAAVGLAYGTVWLGLTELARMSAGDKILIHSA TH_4621|M.thermoresistible__bu TCDADLAVPLPDGLTEGQAAAVSTAHATAWYGLHDLARLGAGEKVLIHSA : . . .. : : : . Mflv_0405|M.gilvum_PYR-GCK TVVSTAADEPIAIVAVSCRFPGAPNPEAFWDLLS-GGVDAIREVPEDRFD MAB_0939|M.abscessus_ATCC_1997 SAVTGRTDEPIAIVAVSCRFPGAPDPEAFWDVLS-GGVDAIREVPEDRFD Mvan_1003|M.vanbaalenii_PYR-1 STVR--TDDPIAIVGMACRFPGADDTDAFWSVLA-EGADLIREIPDDRFD Mb1689|M.bovis_AF2122/97 TGGVG-----MAAVSLARYWG----AEVFVTASR-AKWDTLRAMGFDDIH Rv1661|M.tuberculosis_H37Rv TGGVG-----MAAVSLARYWG----AEVFVTASR-AKWDTLRAMGFDDIH MMAR_2471|M.marinum_M TGGVG-----MAAVQLARLWG----LEVFATASP-GKWDTLRAMGFDDDH MAV_3109|M.avium_104 TGGVG-----MAAVQLARHYG----AEVFATASR-GKWDTLRAMGFDDDH MUL_2266|M.ulcerans_Agy99 TGGVG-----MAAVQLARHLG----LEVYATASK-GKWDILRAMGFDEDH MLBr_00135|M.leprae_Br4923 TGGVG-----MAAVQFARHWG----VEIFVTASR-GKWDTLRDMGFDDDH MSMEG_4727|M.smegmatis_MC2_155 TGGVG-----QAAIAVARAAG----AEIYATAGSEKRRQLLRDWG--IEH TH_4621|M.thermoresistible__bu TGGVG-----LAAIAIARSVG----AQIYATAGSPARRDLLRDMG--IEH : * : .: : : : :* . Mflv_0405|M.gilvum_PYR-GCK IDEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRL MAB_0939|M.abscessus_ATCC_1997 IDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRL Mvan_1003|M.vanbaalenii_PYR-1 INEFYDPDPEAAGKIYSRYGGFLDGVDGFDPEFFGISPREAVWIDPQQRL Mb1689|M.bovis_AF2122/97 ISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLR----LLPSGGR Rv1661|M.tuberculosis_H37Rv ISDSRSLEFEEAFLRATEGSGVDVVLNSLAGEFTDASLR----LLPSGGR MMAR_2471|M.marinum_M IANSRTLEFEEKFRAGTGGVGVDAVLNSLAGEFVDASLR----LLVPGGR MAV_3109|M.avium_104 IGDSRSPDFEQKFLAATGGAGVDVVLNSLAGEFTDASLR----LLAPGGR MUL_2266|M.ulcerans_Agy99 ISDSRSLEFEEKFREVTGGRSVDVVLDSLAGEFVDASLR----LLGPGGV MLBr_00135|M.leprae_Br4923 IGDSRTLEFEEKFLAVTDGRGVDVVLDSLAGDFVDASLR----LLVRGGR MSMEG_4727|M.smegmatis_MC2_155 VYDSRTTAFADQIRTDTDGYGVDIVLNSVTGPAQRAGLE----LLAFGGR TH_4621|M.thermoresistible__bu VYDSRSTAFADEIRRDTDGYGVDVVLNSLPGAAQRAGLE----LLSFGGR : : : .. :: . . . : Mflv_0405|M.gilvum_PYR-GCK MLETVWEGLERAG--YAPSALRGSRTGVFVGVAANEYAHLLSAESIDKIE MAB_0939|M.abscessus_ATCC_1997 MLETVWEGLERAG--YSPAALRGSRTGIFAGVGANEYAHLLSSESIDKIE Mvan_1003|M.vanbaalenii_PYR-1 VLETAWEGLERAG--YSAAALRGSRSGVYVGVGANEYSHLLSGGSLDGIE Mb1689|M.bovis_AF2122/97 FIELGKTDIRDGQ--TVAERHRGVR---YRAFDLVEAGPDRIAAMLSEVV Rv1661|M.tuberculosis_H37Rv FIELGKTDIRDGQ--TVAERHRGVR---YRAFDLVEAGPDRIAAMLSEVV MMAR_2471|M.marinum_M FIEMGKTDLRDPQ--TMAEQHRGVG---YRAFDLIEAGPDLIARMLAELS MAV_3109|M.avium_104 FIEMGKTDVRDPD--VVAQRYRGAR---YRAFDLMEAGPDRTAAMLAEIV MUL_2266|M.ulcerans_Agy99 FLEMGKTDIRDPG--VIAQEYPGVR---YRAFDLFEPGRPRMHQYMLDLA MLBr_00135|M.leprae_Br4923 FLEMGKTDIRDAQ--EIAANYPGVQ---YRAFDLSEAGPVRMQEMLCEVR MSMEG_4727|M.smegmatis_MC2_155 FVEIGKRDIYADTRLGLFPFRRNLSFYAVDLALMTVTHPQKIRDLLATVY TH_4621|M.thermoresistible__bu FIEIGKRDIYGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELLETVY .:* .: . : : Mflv_0405|M.gilvum_PYR-GCK PHFITGNALNAISGRVAFALGLEGPAVAVDTACSSSLVAVHQAT----QA MAB_0939|M.abscessus_ATCC_1997 PYFITGNALNAISGRVAFALGFEGPAVAVDTACSSALVAVHQAV----QA Mvan_1003|M.vanbaalenii_PYR-1 AQFITGNALNVIAGRVSFTLGLEGPAVAVDTACSSSLVAVHQAC----QG Mb1689|M.bovis_AF2122/97 GLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDG----PG Rv1661|M.tuberculosis_H37Rv GLLAAGVLARLPVKTFDARCAPAAYRFVSQARHIGKVVLTIPDG----PG MMAR_2471|M.marinum_M RLLCAETLTPLPIKTFDVRLARQAYRFVSQARHIGKVVLTLPDE----TG MAV_3109|M.avium_104 GLLRAGVLTPLPLKTFDVRCASTAYRYVSQARHIGKVVLTVPSG----PG MUL_2266|M.ulcerans_Agy99 GLFDAGVLRPLPVTAFDVRRAPAALRYLSQARHVGKVVMTMPAD----QG MLBr_00135|M.leprae_Br4923 ELFDTQVLHRLPVTSWDVRCAPAAFRFMSQARHIGKVVLTMPSA----LA MSMEG_4727|M.smegmatis_MC2_155 RLIADGTLPLPEITHYPLEEAATAIRIMGGAQHTGKLVIDIPDTGQSQVV TH_4621|M.thermoresistible__bu RLTADGVLPMPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVPHTGRADVV . . : . :* Mflv_0405|M.gilvum_PYR-GCK LRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFDASADGYVR MAB_0939|M.abscessus_ATCC_1997 LHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGRCKTFDASADGYVR Mvan_1003|M.vanbaalenii_PYR-1 LQSGDCDLALAGGVNVLLSPATTIATSRARMLSPDGRCKTFDAAADGYVR Mb1689|M.bovis_AF2122/97 GQSG-----LAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQ Rv1661|M.tuberculosis_H37Rv GQSG-----LAGGTVVVTGGTGMAGSAVATHLVRRHGVANLVLVSRSGEQ MMAR_2471|M.marinum_M AVPAGA---LAGGTVIITGGTGMAGTALARHVVSRHRVANVILVSRSGAQ MAV_3109|M.avium_104 EVLSGCGGGLAQSTVLITGGTGMAGSALARHLVDRYRVGHVVLVSRTGAQ MUL_2266|M.ulcerans_Agy99 GALG-------GGTVLITGGTGMAGSALARHLVAHHGVAHLVLISRRGPA MLBr_00135|M.leprae_Br4923 DGLA-------EGTVLITGASGAIGGVLARHMVSAYGVRHLVLASRRGDR MSMEG_4727|M.smegmatis_MC2_155 VPPEQVPVFRGDGAYVITGGLGGLGLFLAERMAAAG-CGRIVVNSRSAPS TH_4621|M.thermoresistible__bu VPPEQASPFRSDGAYIVTGGMGGLGLYLAGEMAAAG-AGCIVLNGRSAPS .. :: . . * : . . Mflv_0405|M.gilvum_PYR-GCK SEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGASSGLTVPNGGAQQR MAB_0939|M.abscessus_ATCC_1997 SEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGASSGLTVPNGGAQQR Mvan_1003|M.vanbaalenii_PYR-1 GEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDGASGGLTVPNGGAQQR Mb1689|M.bovis_AF2122/97 ADRA-----AEVAALLREGGAQVAVVSCDVADRD-ALAALLAGLDPRYP- Rv1661|M.tuberculosis_H37Rv ADRA-----AEVAALLREGGAQVAVVSCDVADRD-ALAALLAGLDPRYP- MMAR_2471|M.marinum_M AEGT-----SELLGQLQDAGAEAAVVACDVSDRD-AVAELLAQVPARYP- MAV_3109|M.avium_104 AAGA-----AELVDELQRAGASASVLACDVGDRD-AVATMLAGLPSGYP- MUL_2266|M.ulcerans_Agy99 APGA-----TELVAELSAAGAQVEVVACDAADRP-ALAKVIAENPAQRP- MLBr_00135|M.leprae_Br4923 AEGA-----VELAAELVGAGAKIQVVACDVADND-AVRGLFAQLSREFPP MSMEG_4727|M.smegmatis_MC2_155 TRSS------EIIELIRATGADIVVECGDIAEPDTALRLVAAATQTGLP- TH_4621|M.thermoresistible__bu GEAL------RTIEQLRAAGTEVIVECGXX----XRGQPVEVAVPT---- . . * : . Mflv_0405|M.gilvum_PYR-GCK LIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQAAAAAYAGARDADRP MAB_0939|M.abscessus_ATCC_1997 LIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAAAAYGGSRDADRP Mvan_1003|M.vanbaalenii_PYR-1 VIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQAAGAVLGAGRDPDRP Mb1689|M.bovis_AF2122/97 LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAF Rv1661|M.tuberculosis_H37Rv LKGVFHAAGVLDDAVITGLTPDRVDTVLRAKVDGAWNLHELTEDMDLSAF MMAR_2471|M.marinum_M LRGVIHAAGVLDDGLIASLTPQRVDTVLRAKIDGAWNLHELTRGLNLSAF MAV_3109|M.avium_104 LRGIVHAAGILDDGLLSSLTPDRVDAVLRAKVDGAWNLHELTKDLDLSAF MUL_2266|M.ulcerans_Agy99 LSAVVHAGGVLDDAVISSLTPERVDTVLRAKVDAAWNLHELTRDLDLSAF MLBr_00135|M.leprae_Br4923 VRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEATRDLDLLMF MSMEG_4727|M.smegmatis_MC2_155 LRGVLHAAAVVEDATLANITDELVEHDWAPKVYGAWNLHQAVQSGGPATS TH_4621|M.thermoresistible__bu ---ELRHADEHPDRRGAQLCDEFARGEQG----AQRNQHRTDAGEGQRD- . : . . . Mflv_0405|M.gilvum_PYR-GCK LLMGSVKTNIGHTESASGAAGLIKVVLSLQHETLPQSLHFDTPSPHIPWD MAB_0939|M.abscessus_ATCC_1997 LLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVLPQSLHFDNPSPHIPWE Mvan_1003|M.vanbaalenii_PYR-1 LLMGSVKTNVGHLESASGVAGLIKVVLSLQHEMLPRHLHFKTPSPHIPWD Mb1689|M.bovis_AF2122/97 VVFSSMAGIVGTPAQGN-----YAAANAFLDGLVAYRRSRGLAGLSVAWG Rv1661|M.tuberculosis_H37Rv VVFSSMAGIVGTPAQGN-----YAAANAFLDGLVAYRRSRGLAGLSVAWG MMAR_2471|M.marinum_M VLFSSMAGIIGTAGQGN-----YAAANSFLDGLAVHRRALGLPGVSVAWG MAV_3109|M.avium_104 VVFSSMAGIVGTPGQAN-----YAAANSFLDGLVAHRRADGLAGLSLAWG MUL_2266|M.ulcerans_Agy99 VMFSSMAGVVGSSGQAN-----YAAANTFVDGLAAHRRAHGLPAISLGWG MLBr_00135|M.leprae_Br4923 VLCSSIAATVGSPGQGN-----YSAANAFLDGLAAYRQAAGLAGTSLAWG MSMEG_4727|M.smegmatis_MC2_155 ELDWFCAFSSAAALVGSPGQGAYAAANSWLDAFMQWRRAQGLPATSIAWG TH_4621|M.thermoresistible__bu ------AHPPGAVGHDQPDPGALSDTG------LDERGGQ---------- . . . Mflv_0405|M.gilvum_PYR-GCK SLPVRVVDTAMPWQPNGRPRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTE MAB_0939|M.abscessus_ATCC_1997 SLPVRVVDKAIPWQANGRPRRAGVSSFGFTGTNAHVLIEEAPQPQATP-- Mvan_1003|M.vanbaalenii_PYR-1 RLAVRVVAEPTPWRADGRPRRAGVSSFGFSGTNAHVVLEEPPAQSADLRQ Mb1689|M.bovis_AF2122/97 -LWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTA--------- Rv1661|M.tuberculosis_H37Rv -LWEQASAMTRHLGERDRARMTQAGLAPLTTEQALGFLDTA--------- MMAR_2471|M.marinum_M -LWEQASAMTRHLGERDKARMSRVGLATLSTEHALELFDAA--------- MAV_3109|M.avium_104 -LWEQASAMTAHLGDRDKARMSRIGLAPLSTEQALAAFDAA--------- MUL_2266|M.ulcerans_Agy99 -LWDQASDMTGGMDAADRARLGREGVLALSSDEAMELFDTA--------- MLBr_00135|M.leprae_Br4923 -LWEQPGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAA--------- MSMEG_4727|M.smegmatis_MC2_155 AWGEIGRGTAMAEGDNAIAP------------------------------ TH_4621|M.thermoresistible__bu ---FPGVGVQIPVADPGVGI------------------------------ Mflv_0405|M.gilvum_PYR-GCK PTAPAEPVDEDAAADPAPAPVEVLPLSARSPEALVALAQRYETWLTAHPE MAB_0939|M.abscessus_ATCC_1997 --------DEDDASTPQSAPVSVLPLSARSPEALAAVAQRYESWLAAHPD Mvan_1003|M.vanbaalenii_PYR-1 PPTDGKDGAAGLESATAPEPAGVLPISARSPEALTALARRYESWLTAHPD Mb1689|M.bovis_AF2122/97 -----------LQADRAVVVAARLDRAALAGAGAA--LPALFSQLAAGPT Rv1661|M.tuberculosis_H37Rv -----------LQADRAVVVAARLDRAALAGAGAA--LPALFSQLAAGPT MMAR_2471|M.marinum_M -----------VVADRAVVVATRLDANALKSNSAA--LPPLLGELAARPK MAV_3109|M.avium_104 -----------MLVETPVLVAARLDRAALSENIAA--LPPLLRELAAGPT MUL_2266|M.ulcerans_Agy99 -----------LIVNQAFLAPARIDLAALRAHAVA--VPPMFSDLVSAPT MLBr_00135|M.leprae_Br4923 -----------LVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSR MSMEG_4727|M.smegmatis_MC2_155 --------------DEGAYAFEAILRHDRVYNGYAPVLGASWLTAFAQRS TH_4621|M.thermoresistible__bu --------------DHRG--------AVRVDSGVP-----------AQQG Mflv_0405|M.gilvum_PYR-GCK ADLADVCRTAGTGRSHFEHRAALVVDSVESARIALTDLAQNRLRPGVVRG MAB_0939|M.abscessus_ATCC_1997 VDLEDVCLTAGRGRSHFEHRAALVVDSIQTAREGLLELAQNRLRPGVVRG Mvan_1003|M.vanbaalenii_PYR-1 ADIADVCYTAGAGRSHFEHRAALVVDSVDGARDLLAGLAEDRLGPGAVRG Mb1689|M.bovis_AF2122/97 RRRI---DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR- Rv1661|M.tuberculosis_H37Rv RRRI---DAADTAVSMSGLVSRLHALTPERRQRELTDLVISNAAAVLGR- MMAR_2471|M.marinum_M RRVISDADAGDNIAAATGLVARLHGLSAEQRQRELVDVVCSNAATVLGR- MAV_3109|M.avium_104 RRVI---DDADVTASMSGLAARLHGLSPEARRRELVDLVCGNAAMVLGV- MUL_2266|M.ulcerans_Agy99 RRQID--AALATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGT- MLBr_00135|M.leprae_Br4923 RRQIE--DPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGR- MSMEG_4727|M.smegmatis_MC2_155 PFAELFLADTQGASETRKLRSELAALPREEWPTHLRRLIAEQVGLLLRR- TH_4621|M.thermoresistible__bu VDGEVVRHRTLSS--VRSGRSSRWTAPGSRCGSGRR-----YGGESCRR- . Mflv_0405|M.gilvum_PYR-GCK EHLNHPTTAWMFTGQGSQYPGMARELFDTEPVFADTVTRCADAVADLLPR MAB_0939|M.abscessus_ATCC_1997 EHTNHPTTAWLFTGQGSQYPGMARELFDAEPVFAETVTRCAEAVKDIVTR Mvan_1003|M.vanbaalenii_PYR-1 VCGDPPKTAWLFTGQGSQYPGMARELFDTEPVFRDTVTRCAEAIGDTLPR Mb1689|M.bovis_AF2122/97 ------------SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLS Rv1661|M.tuberculosis_H37Rv ------------SSSVDINAHKAFQDLGFDSLTAVELRNRLKTATGLTLS MMAR_2471|M.marinum_M ------------SSTADINAHRAFQELGFDSLTAVELRNRLKTATGLTLS MAV_3109|M.avium_104 ------------PDPADINAGRAFQDLGFDSLTAVELRNRLKNATGLTLS MUL_2266|M.ulcerans_Agy99 ------------ITPEAIDPDKAFQELGFDSLTAVEMRNRIKTVTGLSLS MLBr_00135|M.leprae_Br4923 ------------PSPEDIDPNTKFQDLGFDSLTAVELRNRLKSATGLTLP MSMEG_4727|M.smegmatis_MC2_155 ----------------TVDPDRPLSEYGLDSLGHLELRTRIETETGVRVS TH_4621|M.thermoresistible__bu ----------------TTGP----------AAGAAARRGRTRRRRRPRRP . . Mflv_0405|M.gilvum_PYR-GCK PLLDVMFAGGREAGVPPTETLRHTSFAQPALFAVEMG------------- MAB_0939|M.abscessus_ATCC_1997 PLLEVMFATDRETGGKAGEALRHTSFAQPALFAVEMG------------- Mvan_1003|M.vanbaalenii_PYR-1 PLLEVLFDTDGDNG----QTLRHTSYAQPALFAIEMG------------- Mb1689|M.bovis_AF2122/97 PTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVD------------- Rv1661|M.tuberculosis_H37Rv PTLIFDYPTPATLAEHLDSRLVTASGSDQQSLSDRVD------------- MMAR_2471|M.marinum_M PTLIFDYPSPAALAEHLGIRLATAT--AQPDLMRRFD------------- MAV_3109|M.avium_104 PTLIFDYPTPVVLAEHLDSRLAGSGGDDQPDLMGRFN------------- MUL_2266|M.ulcerans_Agy99 PTLIFDYPTPNGLANYIRAELAGAPQEVKHTPAVRVTGDDPIAIVGMSCR MLBr_00135|M.leprae_Br4923 PTVIFDHPTPTAVAEYVAQQMLKSR------------------------- MSMEG_4727|M.smegmatis_MC2_155 AMDMTTIRGLAQRLCEMLDTDDAVSAPS---------------------- TH_4621|M.thermoresistible__bu PPPPDRVRHRAG------PAHGPVRR------------------------ . Mflv_0405|M.gilvum_PYR-GCK ---------------------LARLWQSWGIVPDVVLGHSVGQYAAACVA MAB_0939|M.abscessus_ATCC_1997 ---------------------LARLWQSWGIEPDVVLGHSVGQYAAACVA Mvan_1003|M.vanbaalenii_PYR-1 ---------------------LARLWQARGIEPDVVLGHSVGQYAAACVA Mb1689|M.bovis_AF2122/97 ---------------------------DITRELVVLLD-QPDLS------ Rv1661|M.tuberculosis_H37Rv ---------------------------DITRELVVLLD-QPDLS------ MMAR_2471|M.marinum_M ---------------------------DLARELDKLIN-RPDWT------ MAV_3109|M.avium_104 ---------------------------DITRELQALLG-APHWN------ MUL_2266|M.ulcerans_Agy99 YPGGIESPDDLWDMLMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYTR MLBr_00135|M.leprae_Br4923 --------------------------------PAES-------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK G--------------VFSLEDGARLMAERGRLFGSLPEGGRMVAVFADAK MAB_0939|M.abscessus_ATCC_1997 G--------------VFSIEDGARLIAERGRLFGGLPAGGRMVAVFSDAK Mvan_1003|M.vanbaalenii_PYR-1 G--------------VFGLEDGARLVADRGRLFGGLPVGGRMVAVFTDAE Mb1689|M.bovis_AF2122/97 ------------------ANVKAHLRTRLQTMLTSLTT--------EDDD Rv1661|M.tuberculosis_H37Rv ------------------ANVKAHLRTRLQTMLTSLTT--------EDDD MMAR_2471|M.marinum_M ------------------HEDKGKLSGRLHDILADLS---------ADDD MAV_3109|M.avium_104 ------------------SDDKAVLRARIHGLLGALPAGDGPDSAPLDED MUL_2266|M.ulcerans_Agy99 TGGFVDRVGDFEPAFFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGG MLBr_00135|M.leprae_Br4923 -----------------------------------------------GDE MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RVEQVAADFPRVSVGAYNG------------------------------- MAB_0939|M.abscessus_ATCC_1997 HVEQIAGEFPRVSVGAYNG------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 VVEDFADEFPQVSVAAYNG------------------------------- Mb1689|M.bovis_AF2122/97 IAAATESQLFAILDEELGS------------------------------- Rv1661|M.tuberculosis_H37Rv IAAATESQLFAILDEELGS------------------------------- MMAR_2471|M.marinum_M ITTASESQLFAILDEELGS------------------------------- MAV_3109|M.avium_104 LEAATESQLFAILDEELGR------------------------------- MUL_2266|M.ulcerans_Agy99 LRGSATGVFAGVMTQGYGMFAAEPVEGFRLTGQLSSVASGRVAYVLGLEG MLBr_00135|M.leprae_Br4923 TSQAVEPKVEEVSVHA---------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 WRGLSADGRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIK MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 MVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVPWVVSAKSGSALGA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 QAARLAAHVRSHDELDVADVGWSLAGRSTFEHRAVVLGADRDGLLAGLDE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQLLGMGMGLHAGYPVFAEA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 FNTVVGELDRHLLRPLREVIWGHDENLLNTTEFAQPALFAVEVALYRLLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SWGVRPDFVMGHSVGELSAAHVAGVLSLENAAVLVAARGRLMQALPDGGA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------------------------PNTVLSGPGEDLEQIVGTFGEDG MAB_0939|M.abscessus_ATCC_1997 ---------------------------PNTVLSGPGEDLEQAVARFQEEG Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------PNTVLAGPASDLEQIVAGCSGEG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 MIAVQATEQEVLPLLGAQVSIATINGPASVVISGAQDAVSAVAEQLRADG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IRCTWLETSHAFHSELLDPVLDEFESYAAQLQFAAPTLPLVCNRTGAVLT MAB_0939|M.abscessus_ATCC_1997 IRCTWLETSHAFHSELLDPILDEFESYAAQVQFAAPTLPLVCNRTGAVLT Mvan_1003|M.vanbaalenii_PYR-1 IRTTWLDTSHAFHSALLDPVLDEFESCAARLAYAAPTRPLVCNRTGAVVT Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 RRVHRLAVSHAFHSPLMDPMIDEFATVAGELTVNAPTIGIISNLT-GQLA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GQTSLDAQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQ MAB_0939|M.abscessus_ATCC_1997 AQTPIDGQYWRRHSRQPVQFAESVRTVAALGCSVLMEIGPQPVLTGAAVQ Mvan_1003|M.vanbaalenii_PYR-1 GPGVIDAQYWRRHARQPVQFAESVRTLADLGCSVLMEIGPQPFLIAAALR Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GEDFGSAAYWKRHVRDAVRFADSIRFAQSAGAARFLEVGPSIGLTASIEE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VWPEHLAAP--RAIASLRKGVADRRQIADALAAAYIGGHKPDFAALHEQR MAB_0939|M.abscessus_ATCC_1997 VWPEHLAPP--RAIVSLRKGVEDRRQIADALASAYVSGHRPNFAALQRHP Mvan_1003|M.vanbaalenii_PYR-1 VWPESAATP--RAIPSLRKGPDARRQLAEAVAAAYIAGHRLDFTGHDGGP Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VLSDAAVTNPVATASALRKDRPEPVSLVSALAGVFVAGTAVDWRAVVGQS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GVRLELPTYPFQRRRFWPKSAGMAIDGR---VGASAGSGILGSGKDLASG MAB_0939|M.abscessus_ATCC_1997 RRTVELPTYPFQRRRFWPKSSGTAIEG-----GGGLPSGILGRGEDLASG Mvan_1003|M.vanbaalenii_PYR-1 HRRLPLPTYPFQHRSYWPKTAGIRSDG-------SSGSGLLGSAQDLASG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -HFVELPTYAFERRRFWLSGDAVPADAAGLGLQAGEHALLGAVVELPASG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DSVYTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAVGTPAHAKDVF MAB_0939|M.abscessus_ATCC_1997 DSVYISRLSVRSQPWLSDHVIYGTVVVPGATYAAMALAAVGTPARAKDVF Mvan_1003|M.vanbaalenii_PYR-1 DIVHTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAMPTPARVQEVF Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GVVLTGRLSLAAQGWLADHAVGGVVIFPGAGFVELAIRAGDEVGCRVVDE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FYEPIILPEKSSREVQLTVHPSVDGE-SKFQVHSRPYGERGAEWALNAEG MAB_0939|M.abscessus_ATCC_1997 FYEPIILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSLNAEG Mvan_1003|M.vanbaalenii_PYR-1 FYEPIILGDKDSREVQLMLHRTDDADGWTFEVHSRPYGDRDADWSRNASG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LTLAAPLVLPSGGSVAVQVVVGSPDDSGARAVSVYSRGDAGSDWVLHAEG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VVASGVGD---SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLELAWG MAB_0939|M.abscessus_ATCC_1997 TVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLELAWG Mvan_1003|M.vanbaalenii_PYR-1 TVAAGVGD-----AAPDAAADPVDNAIERLTRTRPQQLFDAFADNDLAWG Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 SLGSGSPEPA---------TDLSTWPPVGAVEVENADGYQQLAERGYGYG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFP MAB_0939|M.abscessus_ATCC_1997 PTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFP Mvan_1003|M.vanbaalenii_PYR-1 PAWCSSLRSLWVGTGEAVGDIAVGAELGEHLGREPIHPVLLDLCTGIAGA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PAFR-GLNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDAALHAVIL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQ MAB_0939|M.abscessus_ATCC_1997 AFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQ Mvan_1003|M.vanbaalenii_PYR-1 ALLAAAAQTDADPELFLPLRYGRVEVRERMPRRFYCRARWQTGGIDSETQ Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ASDGADDFGVPEGSVLVPFAWQGVTLHAAGASAVRARIAPAGP------S MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGGDATRLLYTLGWHEV MAB_0939|M.abscessus_ATCC_1997 VFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLGWHEV Mvan_1003|M.vanbaalenii_PYR-1 VFDLDFLDHDGRNLGGIREFTVKRAPREALLRGLGADATRLIYRVGWRET Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AVSIELSDGLGLPVLSVASMLARPVTDQQLRAAVSGAGPDRLFGVDWTAQ MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PVP----ESGDGAAPQGTWLIGGFDELAVSVPGCIPADR----------- MAB_0939|M.abscessus_ATCC_1997 AVPPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRE---------- Mvan_1003|M.vanbaalenii_PYR-1 SPP---VRDDGALGPSSTWLVAGLDALADDVPGSIRIGFDRIWDPDRDGR Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PSA--------ELQPVPVRIWGTVESEGDDDPGASVVFES---------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -----TNPESLRQLLTDAHGRGLPFSGVVWRAAR-SDGDESDAEVAARLE MAB_0939|M.abscessus_ATCC_1997 -----TDPELLGEVLVAAKERGVPFSGVVWRAAG-PGATESTTESAARLE Mvan_1003|M.vanbaalenii_PYR-1 VVLDPADDEHWRRLFALADERRAPVAGVVLGVTGRARPEEPSADFAARLE Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 --------------------------------------VPQAGEVVAGVY MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AEIAELLGAVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAAL MAB_0939|M.abscessus_ATCC_1997 GEIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAAL Mvan_1003|M.vanbaalenii_PYR-1 AQIRDVLGAVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSAL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 AATAAVLEVLRSWL-----SRDGAGQLIITTRGAVALPDEDVTDLAGSAV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK WGFGRTAINEEPALRCRLVDCDGSPQAVQALAALLSTPVDEPELAVRQGK MAB_0939|M.abscessus_ATCC_1997 WGFGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTPVDEPEIAVRQGK Mvan_1003|M.vanbaalenii_PYR-1 WGLGRTLIAEEPGLRCLLVDLDGSEDAGPALARLLGAPGDEPELALRQGR Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 WGLVRSAQTEHP---GRIVLVDTDAQLDEHAVAAVLAAGEPQVLWRNGEV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LLASRLLPWSRSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVPPPA--E MAB_0939|M.abscessus_ATCC_1997 LLASRLLPWSRTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVPAPD--E Mvan_1003|M.vanbaalenii_PYR-1 LLVPRLLPWSRSGQLAIPRGTDYVLAPTERGVLDNLRVSETEVTAPP--E Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 YTARVHGSRAVAGLLVPPGDGPWRLGMSTAGTFENLRLEPIPDADAALQP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLD MAB_0939|M.abscessus_ATCC_1997 GYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVE Mvan_1003|M.vanbaalenii_PYR-1 GHVQVRVEAAGLNFRDVLNALGLYPGDPGPIGGELAGVVTAPGPDVDGFD Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 GHVRVALSAMAANFRDVMIALGLYPDPDAAMGVEGAGVVVETASPDGRFA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VGQRVYGSMQGAFASRFNVPGQFLAPIPDGVSAVEAATIPAAALTVR-LS MAB_0939|M.abscessus_ATCC_1997 VGQRVYGSMQGAFGSRFNVPAQFLAPIPDGISGVEAATIPAAALTVR-LS Mvan_1003|M.vanbaalenii_PYR-1 VGQRVFGFAVGAFASRVNVPVQFLAPVPEGISAVAAATTPAAVLTAG-LA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VGDRVVGLFPEGTGTIAITDHRLLVKIPAGWSDTAAATTSVVFATAFYAL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FDWAQVKSGDKVLIHAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRK MAB_0939|M.abscessus_ATCC_1997 FDWAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRK Mvan_1003|M.vanbaalenii_PYR-1 FDWAALRAGDRVLIHAASGGVGLAAVQLARQRGATVFATASGYKRPMLRA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 RDLASVQPGQRILVHAATGGVGMAAVQLARHWGLEVFATASKGKWDTLRA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LG--VKHVYDSRTTDFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATA MAB_0939|M.abscessus_ATCC_1997 LG--VKYVYDSRTTDFADQILADTDGAGVDVVLNSLTSEGFIEATLRATA Mvan_1003|M.vanbaalenii_PYR-1 MG--VDHVYDSRTTDFADQILADTDGAGVDVVLNSLTNDGFVAATVRATA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 MGFDEDHIGDSRSLEFEDKFRAATGGRGMDVVLDSLAGE-FVDASLRLVA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK QHGRFAEIAKRDIWTVEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTE MAB_0939|M.abscessus_ATCC_1997 KNGRFAEIAKRDIWTTEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTE Mvan_1003|M.vanbaalenii_PYR-1 RNGRFAEIAKRDIWSPEQMAAARPDIDYEVLALDAVMQQDPDRIQLLLAD Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 PGGVFLEMGKTDIREAAVVAQQHTGVRYRAFDLFEAG---PDHIAQILAE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VSAGLRDGAWTPLPAEVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQPQ MAB_0939|M.abscessus_ATCC_1997 VSEGLAKGEWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAPR Mvan_1003|M.vanbaalenii_PYR-1 LADSLARGETAPLPFEAYPLAEATTAFRRMQQARHTGKIILQMPKPLQPH Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LAALFSEDVLRPLPVTTFDVRRAPAALRYLSQARHVGKVVLTMPDAWAAG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PDRSYLITGGLGAIG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADI MAB_0939|M.abscessus_ATCC_1997 PDRTYLITGGLGAIG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEI Mvan_1003|M.vanbaalenii_PYR-1 GDRSYLITGGLGALG-LHAAAYLAQLGAGDIVLTGRRMPDAATERAISEI Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 ---TVLITGGTGMAGSALARHVVAHHGVRQLVLVSRRGPDAPGAAELAEE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ADRTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALL MAB_0939|M.abscessus_ATCC_1997 TERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALL Mvan_1003|M.vanbaalenii_PYR-1 AERYHCRIHTFAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 LSAFGAQVQVVACDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SQQSVERFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQS MAB_0939|M.abscessus_ATCC_1997 GQQSVERFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQS Mvan_1003|M.vanbaalenii_PYR-1 PQQSPERFRTTLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQA Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TSLTPERIETVLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NYATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAAN----- MAB_0939|M.abscessus_ATCC_1997 NYATANALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAATAN----- Mvan_1003|M.vanbaalenii_PYR-1 NYATANAVLDGLVAHRKARGLPATGVNWGPWAQGGMATSDAARAN----- Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 NYAAANSFLDGLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------ISAQGLIPLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVL MAB_0939|M.abscessus_ATCC_1997 -------ISAQGLIPLDPSAALAALAEVVANGTGQATILKANWQRAAKVL Mvan_1003|M.vanbaalenii_PYR-1 -------LGAQGLIPLEPTAALNALGEIVAHGIASAVVLKANWQRAAKLL Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 RDGIVAMSSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GSSRPPILDLVLPSAVGEITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQ MAB_0939|M.abscessus_ATCC_1997 GSSRPPILDLVLPSAVGEVTGDSELLKQLMEIPVPQRAGFVTEFLQREVQ Mvan_1003|M.vanbaalenii_PYR-1 GATRPPILDHVLPSAVAAGPGDSALLKQLQDVPEAQRGSFVTEHLQRELQ Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 VDLINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVF MAB_0939|M.abscessus_ATCC_1997 NFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVF Mvan_1003|M.vanbaalenii_PYR-1 QILGLAQPP--AATGRFLELGMDSLMAVELRNRLVGQFGSGFTITATAVF Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 TVLGNSSPDAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DYPTIGGLAEYLVAQLPDAETPQAAP-------QSESEPGPDVTE----- MAB_0939|M.abscessus_ATCC_1997 DYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAASDAVSE Mvan_1003|M.vanbaalenii_PYR-1 DYPTIGALAEYLAAQTPESTEEGTEMK------TADPDGQPATVGHADVV Mb1689|M.bovis_AF2122/97 -------------------------------------------------- Rv1661|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_2471|M.marinum_M -------------------------------------------------- MAV_3109|M.avium_104 -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 DYPNSAALAGYMHRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MSMEG_4727|M.smegmatis_MC2_155 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ------------------------------------------------ MAB_0939|M.abscessus_ATCC_1997 LKE--------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LQTS-------------------------------------------- Mb1689|M.bovis_AF2122/97 ------------------------------------------------ Rv1661|M.tuberculosis_H37Rv ------------------------------------------------ MMAR_2471|M.marinum_M ------------------------------------------------ MAV_3109|M.avium_104 ------------------------------------------------ MUL_2266|M.ulcerans_Agy99 GVLELLLALANETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE MLBr_00135|M.leprae_Br4923 ------------------------------------------------ MSMEG_4727|M.smegmatis_MC2_155 ------------------------------------------------ TH_4621|M.thermoresistible__bu ------------------------------------------------