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VNADALVLTKPRTLERRHLPVPRIDDESGLLRIEACGLCGTDHEQFSGHLPTGFAFIPGHEIIGVIEGIG DAARERWGVSVGQRVAVEVFRSCRECDSCGRGEYRRCSSNGLATMFGFVDVNIPPGLWGGYATHLHLPFD SMPLPVPDGLDPIVATLFNPLGAGIKWAAMLPETSPGDVVAVLGPGIRGICAAVAAKEAGAAFVAMTGVG PRDRTRLAAAHQFGVDLTIDVTEDDPAQALQMATGRLADVVVDVTAKAPAAFADAVALAQPGGRVVVAGT RGGGGAPGFEPDLLVFKELRIFGSLGVDYPAYQSAIELLVSRRWPFEELHREITGFAGLPRLLDLLAGNE PDRVPALHNVFVPIA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4626 | - | - | 100% (365) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4997 | - | 8e-26 | 30.39% (283) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0236 | - | 1e-21 | 33.98% (256) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1557 | adh | 1e-127 | 63.06% (360) | alcohol dehydrogenase adh |
| M. tuberculosis H37Rv | Rv1530 | adh | 1e-127 | 63.06% (360) | alcohol dehydrogenase adh |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-15 | 27.70% (278) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_2041c | - | 1e-152 | 69.61% (362) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_3163 | - | 1e-152 | 69.61% (362) | Zn-dependent alcohol dehydrogenase |
| M. avium 104 | MAV_2812 | - | 2e-20 | 34.12% (255) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_6296 | - | 9e-27 | 32.35% (340) | 5-exo-alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 7e-18 | 29.92% (254) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 8e-22 | 29.67% (300) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_4901 | - | 2e-27 | 29.66% (327) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2041c|M.abscessus_ATCC_199 ---------------MIAEAMVLTGPRSLQRRQMIIPD-VGDRGAILRVE
MMAR_3163|M.marinum_M ---------------MIAEAMVLTGPRNLERRQMTIPD-VGDRGAILRVE
Mflv_4626|M.gilvum_PYR-GCK ---------------MNADALVLTKPRTLERRHLPVPR-IDDESGLLRIE
Mb1557|M.bovis_AF2122/97 -----------MSDGAVVRALVLEAPRRLVVRQYRLPR-IGDDDALVRVE
Rv1530|M.tuberculosis_H37Rv -----------MSDGAVVRALVLEAPRRLVVRQYRLPR-IGDDDALVRVE
MLBr_01784|M.leprae_Br4923 ------------MSQTVRGVISRKKDEPVELVDIVIPD-PGPGEAVVDVT
TH_4627|M.thermoresistible__bu ------------MSQSVRGVIARKKDEPVEVVDIVIPD-PGPGEVVVKVT
MAV_2812|M.avium_104 ----------------------------MELVDTETRP-PGRDEVRLTVG
MUL_0495|M.ulcerans_Agy99 MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPT-PGYGEALVKLE
MSMEG_6296|M.smegmatis_MC2_155 -------MRATTLPKSTQAAVVRNFGEPLTLEEVAVPQTVAPGGLLVEIV
Mvan_4901|M.vanbaalenii_PYR-1 ----MFHSGTHKVKETAMKAMVYHGDGKASWDDVPDAVLVDPTDAVVRVD
. : :
MAB_2041c|M.abscessus_ATCC_199 ACGLCGTDHEQFTGHLP--AGFSFVPGHEIVGIVEHVGAAAGQRWGVQAG
MMAR_3163|M.marinum_M ACGLCGTDHEQFTGHLP--AGFSFVPGHEIVGIVEHVGNAASERWCVRAG
Mflv_4626|M.gilvum_PYR-GCK ACGLCGTDHEQFSGHLP--TGFAFIPGHEIIGVIEGIGDAARERWGVSVG
Mb1557|M.bovis_AF2122/97 ACGLCGTDHEQYTGELA--GGFAFVPGHETVGTIAAIGPRAEQRWGVSAG
Rv1530|M.tuberculosis_H37Rv ACGLCGTDHEQYTGELA--GGFAFVPGHETVGTIAAIGPRAEQRWGVSAG
MLBr_01784|M.leprae_Br4923 ACGVCHTDLTYREGGIN--DRYPFLLGHEAAGTVEVVGPGVTA---VEPG
TH_4627|M.thermoresistible__bu ACGVCHTDLHYREGGIN--DEFPFLLGHEAAGTVESVGSGVTN---VEPG
MAV_2812|M.avium_104 ACGICGTDAHFVNGAFPGLSWP-LTPGHEIAGRIAELGEGVEG---FAVG
MUL_0495|M.ulcerans_Agy99 TSGVCHTDLHAAHGDWPVKPAPPFVPGHEGCGTVVALGDGVTD---LKVG
MSMEG_6296|M.smegmatis_MC2_155 ACSLCGTDVHCWEGSLAIPVGLPLILGHEMVGRIIAIGDGADVDSAGQPL
Mvan_4901|M.vanbaalenii_PYR-1 AVTICGTDLHILRGHVP-TVDRGRILGHEAVGTVTAIGSGVRQ---LAVG
: :* ** * *** * : :* .
MAB_2041c|M.abscessus_ATCC_199 QR-VAVEVF-RSCRDCPECRRGEYRRCA--VNGIATMFGFVDVEIGAGLW
MMAR_3163|M.marinum_M QR-VAVEVF-RSCRDCPECRRGEYRRCA--VNGIATMFGFVDVEIGAGLW
Mflv_4626|M.gilvum_PYR-GCK QR-VAVEVF-RSCRECDSCGRGEYRRCS--SNGLATMFGFVDVNIPPGLW
Mb1557|M.bovis_AF2122/97 DR-VAVEVF-QSCRQCANCRGGEYRRCV--RHGLADMYGFIPVDREPGLW
Rv1530|M.tuberculosis_H37Rv DR-VAVEVF-QSCRQCANCRGGEYRRCV--RHGLADMYGFIPVDREPGLW
MLBr_01784|M.leprae_Br4923 DF-VILNWR-AVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTPALG
TH_4627|M.thermoresistible__bu DF-VVLNWR-AVCGQCRACKRGRPHLCFDTFNATQKMTLGDGTELTPALG
MAV_2812|M.avium_104 QR-VAVGWFGGCCYRCDPCRAGLFIHCVNGKVPSWHYP------------
MUL_0495|M.ulcerans_Agy99 DK-VGNAWLWSACGSCEQCRTGWETLCENQRNGGYTVN------------
MSMEG_6296|M.smegmatis_MC2_155 QIGDRILWTHAVCGRCVMCAKKRPTLCR-----NKIPYGQATMDQWPNLL
Mvan_4901|M.vanbaalenii_PYR-1 DR--VLISCISSCGSCRYCRRTSYGQCS--GGGGWILGNRIDG-------
: * * * *
MAB_2041c|M.abscessus_ATCC_199 GGYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAGIQWGATLPDTKA-G
MMAR_3163|M.marinum_M GGYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAGIQWGKTLPDTKA-G
Mflv_4626|M.gilvum_PYR-GCK GGYATHLHLPFDSMPLPVPDGLDPIVATLFNPLGAGIKWAAMLPETSP-G
Mb1557|M.bovis_AF2122/97 GGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKP-G
Rv1530|M.tuberculosis_H37Rv GGYAEYQYLAPDSMVLRVAGDLSPEVATLFNPLGAGIRWGVTIPETKP-G
MLBr_01784|M.leprae_Br4923 IGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRD
TH_4627|M.thermoresistible__bu IGAFAEKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGVGAAINTGAVSRD
MAV_2812|M.avium_104 -GGYAESVTVPTSALARIPEELTDAEAAPMGCAGVTTYNALRHTKALP-G
MUL_0495|M.ulcerans_Agy99 -GSFGTYMLVNADYAARIPDGADPLEVAPILCAGVTVYKGLKVTDTRP-G
MSMEG_6296|M.smegmatis_MC2_155 GGLAQHSYVLPGSGRLRVPDGVPDDLASMASCALRSVVNAVEQAGRVGPE
Mvan_4901|M.vanbaalenii_PYR-1 TQAEFVRVPFADNSTHRVPDGVSDENMITLADLLPTGYEVGAINGRVRPA
:
MAB_2041c|M.abscessus_ATCC_199 DVVAILGPGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIARSFGVD-
MMAR_3163|M.marinum_M GIVAILGPGIRGICAAVAAKEAGAAFVAMTGIGPRDDQRLAIARSFGVD-
Mflv_4626|M.gilvum_PYR-GCK DVVAVLGPGIRGICAAVAAKEAGAAFVAMTGVGPRDRTRLAAAHQFGVD-
Mb1557|M.bovis_AF2122/97 DVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGAD-
Rv1530|M.tuberculosis_H37Rv DVVAVLGPGIRGLCAAAAAKGAGAGFVMVTGLGPRDADRLALAAQFGAD-
MLBr_01784|M.leprae_Br4923 DTVAVIGCGGVGDAAISGAALVGANRIIAVDID---DTKLEWARTFGAT-
TH_4627|M.thermoresistible__bu DTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTD---AKKLDWAREFGAT-
MAV_2812|M.avium_104 DRVAILGVGGLGHLGVQFAAAMG-FETIAINRG---TGKADDARKLGAH-
MUL_0495|M.ulcerans_Agy99 QWVAISGIGGLGHVAVQYARAMG-LRVVAIDID---DDKLALAARLGAE-
MSMEG_6296|M.smegmatis_MC2_155 HTVVVQGAGPLGILATGLFAQAGAGRVITVGAP---DTRLEIASEFGAHD
Mvan_4901|M.vanbaalenii_PYR-1 DTVVVVGAGPIGLAAIMTSQLFSPSRIVAIDLA---DSRLDAARKFGAD-
*.: * * * . . . : * :*.
MAB_2041c|M.abscessus_ATCC_199 ---LPIDVSQDDAATALQRETGGRLADVVVDVTAKAPSAFADAVGLARPG
MMAR_3163|M.marinum_M ---LPIDVSQDDAVTALQRETGGQLADVVIDVTAKAPSAFADAVALARPG
Mflv_4626|M.gilvum_PYR-GCK ---LTIDVTEDDPAQALQMATG-RLADVVVDVTAKAPAAFADAVALAQPG
Mb1557|M.bovis_AF2122/97 ---LAVDVAIDDPVAALTEQTG-GLADVVVDVTAKAPAAFAQAIALARPA
Rv1530|M.tuberculosis_H37Rv ---LAVDVAIDDPVAALTEQTG-GLADVVVDVTAKAPAAFAQAIALARPA
MLBr_01784|M.leprae_Br4923 ---HTVNALELEVVKTIQDLTSGFGVDVVIDTVGRP-ETWKQAFYARDLA
TH_4627|M.thermoresistible__bu ---HTIDASSTDVVEAIQELTDGFGADVVVDAVGRP-ETWEQAFYARDLA
MAV_2812|M.avium_104 ---HYIDS-TAEDPAEALRALG--GAAVVLATAGNS-QAMAATVGGLAPQ
MUL_0495|M.ulcerans_Agy99 ---LVVNARTSDVVAQVQEATG--GVHGVLVTAVHP-QAFGQAIGLARRG
MSMEG_6296|M.smegmatis_MC2_155 VISLAAHPDPDDRLAMIRDATDGLGADLVAEFSGHP-AAFAEGVEMAAPD
Mvan_4901|M.vanbaalenii_PYR-1 ---IVINPDRLDPVAAIADLTGGLGVDAAMEAVGTA-ATFELAVQLVRPG
. : . . . . : .
MAB_2041c|M.abscessus_ATCC_199 GTIVVAGTRGGG-GAPRFEPDLLVYKELHVVGALG--VEYPAYRAALEIL
MMAR_3163|M.marinum_M GRVVVAGTRGGG-GAPGFEPDTLVYKELHIAGALG--VEYPAYRAALEIL
Mflv_4626|M.gilvum_PYR-GCK GRVVVAGTRGGG-GAPGFEPDLLVFKELRIFGSLG--VDYPAYQSAIELL
Mb1557|M.bovis_AF2122/97 GTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALG--VDATAYRAALDLL
Rv1530|M.tuberculosis_H37Rv GTVVVAGTRGVGSGAPGFSPDVVVFKELRVLGALG--VDATAYRAALDLL
MLBr_01784|M.leprae_Br4923 GTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLY
TH_4627|M.thermoresistible__bu GTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYGDCLPERDFPTLINLY
MAV_2812|M.avium_104 GELVTIGVTP--EPLPISPLQLITPGLSIVGHPSG---TAKDVEDTMQFA
MUL_0495|M.ulcerans_Agy99 GTIVFNGLPP--GDFPAPIFVIVLKGLTIRGSIVG---TRQDMAEALDFY
MSMEG_6296|M.smegmatis_MC2_155 GRYLVVGQLG--AGVTTIAPGTITKKNLNVIGSFSGDLSHYRTALTILER
Mvan_4901|M.vanbaalenii_PYR-1 GHVANIGVHG--GPATLHLEDIWIRNLTITTGLVD----TYSTPTLVDLV
* * . :
MAB_2041c|M.abscessus_ATCC_199 AMGRWPFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP----
MMAR_3163|M.marinum_M ATRRWPFDRITRESTGFAGLAPLLSSLADENAKSSAALHNVFVPTPSQHA
Mflv_4626|M.gilvum_PYR-GCK VSRRWPFEELHREITGFAGLPRLLDLLAGNEPDRVPALHNVFVPIA----
Mb1557|M.bovis_AF2122/97 VSGRYPFASLPRRCVRLEGAEDLLATMAGER-DGVPPIHGVLTP------
Rv1530|M.tuberculosis_H37Rv VSGRYPFASLPRRCVRLEGAEDLLATMAGER-DGVPPIHGVLTP------
MLBr_01784|M.leprae_Br4923 LQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----------
TH_4627|M.thermoresistible__bu LQGRLPLEKFVTERIALDEVEGAFEKMQRGEVLRSVVVLK----------
MAV_2812|M.avium_104 VLS---GVRAWIEELPLSRAADGYAALEGGRAHYRTVLTM----------
MUL_0495|M.ulcerans_Agy99 ARG---LIHPTVEGAALEDINHVFERMERGQIDGRVVIDYR---------
MSMEG_6296|M.smegmatis_MC2_155 YADRLPFDRLITGHYPLRDIDSVMGRMQSFQEIKPVLLPQETQA------
Mvan_4901|M.vanbaalenii_PYR-1 AAHRLDTSALVTHRYPLDEFERAYHEFSNAGETGALKVLLTQN-------
: : :
MAB_2041c|M.abscessus_ATCC_199 --------------------
MMAR_3163|M.marinum_M ELQQRKVTRDENGTRTDARP
Mflv_4626|M.gilvum_PYR-GCK --------------------
Mb1557|M.bovis_AF2122/97 --------------------
Rv1530|M.tuberculosis_H37Rv --------------------
MLBr_01784|M.leprae_Br4923 --------------------
TH_4627|M.thermoresistible__bu --------------------
MAV_2812|M.avium_104 --------------------
MUL_0495|M.ulcerans_Agy99 --------------------
MSMEG_6296|M.smegmatis_MC2_155 --------------------
Mvan_4901|M.vanbaalenii_PYR-1 --------------------