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STVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQPELAALIVQGKFRGDVLDVGC GEAAISLALAERGHTTVGLDLSPAAVELARHEAAKRGLANASFEVADASSFTGYDGRFDTIVDSTLFHSM PVESREGYLQSIVRAAAPGASYFVLVFDRAAIPEGPINAVTEDELRAAVSKYWIIDEIKPARLYARFPAG FAGMPALLDIREEPNGLQSIGGWLLSAHLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0560c | - | - | 100% (241) | POSSIBLE BENZOQUINONE METHYLTRANSFERASE (METHYLASE) |
| M. tuberculosis H37Rv | Rv3699 | - | 8e-56 | 51.71% (234) | hypothetical protein Rv3699 |
| M. tuberculosis H37Rv | Rv1377c | - | 2e-28 | 36.36% (187) | putative transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0575c | - | 1e-136 | 100.00% (241) | benzoquinone methyltransferase |
| M. gilvum PYR-GCK | Mflv_1324 | - | 1e-57 | 53.60% (222) | methyltransferase type 11 |
| M. leprae Br4923 | MLBr_00551 | - | 2e-06 | 30.69% (101) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0393 | - | 2e-81 | 68.44% (225) | methyltransferase |
| M. marinum M | MMAR_0909 | - | 7e-90 | 70.87% (230) | methyltransferase |
| M. avium 104 | MAV_0119 | - | 5e-89 | 73.76% (221) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2539 | - | 1e-81 | 67.98% (228) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. thermoresistible (build 8) | TH_1722 | - | 6e-61 | 55.16% (223) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_0662 | - | 1e-76 | 68.78% (205) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5471 | - | 3e-61 | 56.58% (228) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1324|M.gilvum_PYR-GCK ------------------MAEVMDWDSAYRGEGE-FE--GEPPWNIGEPQ
Mvan_5471|M.vanbaalenii_PYR-1 ---------------MAHMTDVMDWDSAYRGEGD-FE--GEPPWNIGEPQ
TH_1722|M.thermoresistible__bu --------MATEDPGTGDPTDTIDWDSVYRQEAPGFD--GPPPWNIGEPQ
Rv0560c|M.tuberculosis_H37Rv MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQ
Mb0575c|M.bovis_AF2122/97 MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQ
MAV_0119|M.avium_104 --------------MGMSQPTHEMFEAAYRGESPEMGEGARPPWSIGEPQ
MSMEG_2539|M.smegmatis_MC2_155 ----------------MTTP-EDLFESAYRGEAPNFG-GVRPPWSIGEPQ
MMAR_0909|M.marinum_M ----------------MTESLDLQFETAYRGESAEFGAGIRPPWSLGEPQ
MUL_0662|M.ulcerans_Agy99 ----------------MTESLDLQFATAYRGESAEFGAGIRPPWSLGEPQ
MAB_0393|M.abscessus_ATCC_1997 -----------MTDKTATEEFDLAFDAAYRGEAP-DGRGARPPWSIGEPQ
MLBr_00551|M.leprae_Br4923 -------------MNLYTPIHEDQSLAAIHRAMWALGDYALMAEEVMAPL
:. : . .: *
Mflv_1324|M.gilvum_PYR-GCK PELAALWRDGRFRSEVLDAGCGHAELSLALAADGYTVTGVDISPTAMAAA
Mvan_5471|M.vanbaalenii_PYR-1 PELAALWRDGKFRSEVLDAGCGHAELSLALAADGYTVTGVDLSPTAVAAA
TH_1722|M.thermoresistible__bu PELAALHRAGAFRSDVLDAGCGHAEISMALAADGYTVVGIDLSPTAIAAA
Rv0560c|M.tuberculosis_H37Rv PELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELA
Mb0575c|M.bovis_AF2122/97 PELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELA
MAV_0119|M.avium_104 PEIAALIEAGKFHGDVLDAGCGEAAVSLYLAERGFTTVGLDQSPTAIKLA
MSMEG_2539|M.smegmatis_MC2_155 PEIRKLIDAGKFHGEVLDAGCGEAATALYLAAQGFTTVGLDQSPTAIELA
MMAR_0909|M.marinum_M PELATLIEQGKVHGEVLDAGCGEAALALALAGRGHPVVGLDMSPTAVELA
MUL_0662|M.ulcerans_Agy99 PELATLIEQGKVHGEVLDAGCGEAALAMALAGRGHPVVGLDISPTAVELA
MAB_0393|M.abscessus_ATCC_1997 PEIAMLIAEGKVRGEVLDAGCGEAATSLYLAEVGHTTVGLDSAPKAIELA
MLBr_00551|M.leprae_Br4923 GPILVTATGIRPGMQVLDVAAGSGNISLPAAKTGATIVSTDLTPELLQRS
: :***...* . :: * * . .. * :* : :
Mflv_1324|M.gilvum_PYR-GCK SAAAAERGLSEKASFVAADITALSGF----DGRFSTVVDSTLFHSLPVES
Mvan_5471|M.vanbaalenii_PYR-1 TAASAERGLSERTSFVAADITTLTGF----DGRFATVVDSTLFHSLPVES
TH_1722|M.thermoresistible__bu NRTAQERGLAT-ASFVQGDITDFGGY----DGRFNTIIDSTLFHSIPVQA
Rv0560c|M.tuberculosis_H37Rv RHEAAKRGLAN-ASFEVADASSFTGY----DGRFDTIVDSTLFHSMPVES
Mb0575c|M.bovis_AF2122/97 RHEAAKRGLAN-ASFEVADASSFTGY----DGRFDTIVDSTLFHSMPVES
MAV_0119|M.avium_104 REKAARRGLTS-ASFEVADISDFTGY----DGRFGTIVDSTLFHSMPVEL
MSMEG_2539|M.smegmatis_MC2_155 RAEAARRGLTN-ATFEVADISSFTGY----DGRFGTIVDSTLFHSMPVEL
MMAR_0909|M.marinum_M GREAARRGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVEL
MUL_0662|M.ulcerans_Agy99 GREAARPGLTN-ASFAVADITDFASYPPESAGRFNTIMDSTLFHSMPVEL
MAB_0393|M.abscessus_ATCC_1997 KGYAAERGLTN-ASFAVADISSFTGY----DGRFDTIIDSTLFHSMPVGL
MLBr_00551|M.leprae_Br4923 QARATELGLTL--EYREADAQALPFG----DGEFDVVMSAIGVMFAPDHR
: . **: : .* : *.* .::.: . *
Mflv_1324|M.gilvum_PYR-GCK RAG---------------------------------YLESVHRAARPGAG
Mvan_5471|M.vanbaalenii_PYR-1 RDG---------------------------------YLQSVHRAAAPGAG
TH_1722|M.thermoresistible__bu RDG---------------------------------YLRSIHRAAAPGAR
Rv0560c|M.tuberculosis_H37Rv REG---------------------------------YLQSIVRAAAPGAS
Mb0575c|M.bovis_AF2122/97 REG---------------------------------YLQSIVRAAAPGAS
MAV_0119|M.avium_104 REG---------------------------------YQRSIVQAAAPGAS
MSMEG_2539|M.smegmatis_MC2_155 RDG---------------------------------YQQSIVRAAAPGAT
MMAR_0909|M.marinum_M REG---------------------------------YQRSIVRAAAPGAS
MUL_0662|M.ulcerans_Agy99 REG---------------------------------CQRSIVRAAAPGAS
MAB_0393|M.abscessus_ATCC_1997 RAG---------------------------------YQRSIVRAAAPGAR
MLBr_00551|M.leprae_Br4923 RAASELVRVCRPNGTIGVISWTQEGFFGRMLATIRPYRPSLSAALPPAAL
* . *: * *.*
Mflv_1324|M.gilvum_PYR-GCK FFVLVFAKGAFPADTEQGP-----NEVSEIELREAVSPYWTIDDIRPALI
Mvan_5471|M.vanbaalenii_PYR-1 YFVLVFAKGAFPAEMEGGP-----NEVTELELREAVSRYWIIDDIRPALI
TH_1722|M.thermoresistible__bu YFALVFAKGAFPEEMEQGPG---PNPVDEDELREAVSKYWEIDEIRPAFI
Rv0560c|M.tuberculosis_H37Rv YFVLVFDRAAIP-EGPINA-------VTEDELRAAVSKYWIIDEIKPARL
Mb0575c|M.bovis_AF2122/97 YFVLVFDRAAIP-EGPINA-------VTEDELRAAVSKYWIIDEIKPARL
MAV_0119|M.avium_104 YFVLVFDRNAMPAEGPVNA-------VTEDELREVVGKYWVIDEIRPARI
MSMEG_2539|M.smegmatis_MC2_155 YVVLVFDKTTMGDTGPANP-------VTDDELRDVVGRYWVIDDISPARI
MMAR_0909|M.marinum_M YFVLVFDKAALSGDGPING-------VTEEELRDAVSKYWVIDEIRPARI
MUL_0662|M.ulcerans_Agy99 YFVLVFDKAALSGDGPING-------VTEEELRDAVSKHWVIDEIRPARI
MAB_0393|M.abscessus_ATCC_1997 YYVLVFDRAAFPAESPVNA-------VTENELRDAVSKYWAIDEIRPAKI
MLBr_00551|M.leprae_Br4923 WGREAYIRGLLDDTVTNVKTERRQLEVKRFNSAEGVHNYFKNHYGPTIEA
: .: : : * : * :: . .
Mflv_1324|M.gilvum_PYR-GCK HTNVPKLPGMPPPPLD---MLDDR--GHLRMQ-------------AFLLS
Mvan_5471|M.vanbaalenii_PYR-1 DTNVPKLPGMPPPPLD---MLDDR--GRLRMQ-------------AFLLQ
TH_1722|M.thermoresistible__bu HANMP--PDVPGVESF---DTDEK--GRTKLP-------------AFLLS
Rv0560c|M.tuberculosis_H37Rv YARFPAGFA-GMPALL--DIREEP-NGLQSIG-------------GWLLS
Mb0575c|M.bovis_AF2122/97 YARFPAGFA-GMPALL--DIREEP-NGLQSIG-------------GWLLS
MAV_0119|M.avium_104 HANVPENFLAAFEAFAGADIRDED-NGRKSVG-------------AWLLS
MSMEG_2539|M.smegmatis_MC2_155 HANVPAEFT-DFAAFAGSDIRDEG-NGRKSVA-------------GWLLQ
MMAR_0909|M.marinum_M HANLPPEVS-GMPAFD---ARDEP-EGRKSVG-------------AWLLS
MUL_0662|M.ulcerans_Agy99 HANLPPEVP-GCPPST---LATNPRAASPSVRGCSQPIWADGTPHAVYSP
MAB_0393|M.abscessus_ATCC_1997 YANFNGFEPGVARGFAR--HEIEP-DGRASVA-------------AWLLS
MLBr_00551|M.leprae_Br4923 YTNIGDNSVLAAELDAQLTELAQKYLTNSTMG-----------WEYLLLT
:.. : :
Mflv_1324|M.gilvum_PYR-GCK AHKEP
Mvan_5471|M.vanbaalenii_PYR-1 AHKES
TH_1722|M.thermoresistible__bu AHKA-
Rv0560c|M.tuberculosis_H37Rv AHLG-
Mb0575c|M.bovis_AF2122/97 AHLG-
MAV_0119|M.avium_104 AHLG-
MSMEG_2539|M.smegmatis_MC2_155 AHLG-
MMAR_0909|M.marinum_M AHLG-
MUL_0662|M.ulcerans_Agy99 ANEG-
MAB_0393|M.abscessus_ATCC_1997 AHLAG
MLBr_00551|M.leprae_Br4923 AQKH-
*: