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RHDDDRMTVAGLLDESLMSGAHVLTGADRLDQQVHWVLPLSEVMSRHDALDGVAVYTRPEALLGNGGTLA PLAARGATALLVDGTVPADFPTAAVPADMVVVEMAFPVGFAALNRLLAERALSQEVHAMRYATHVHASLA GLFHRGAGLQLLVREVSNLARNPAMALDARGNVVAHNGFTAETAAALTESILPLLTADLPAAARLSAHHD TRVERFGAPGGGVWTVISTAIRLGKAFEGWVLVVVPSAEPGGHDLARHIVVTEQATAIIGSEMLRQHSVD EAEERARGDFVQALVHGHFSSEHDMRARADYHEIDIDSVFGVFVAPGAVPRGVDNPAASMVRLARYAANV APDPAVRSYVTVLGDVLVVVRSLRGADDTAMRKEMTRYAEAMADELQNRRGTPAAVAYSRPARGAQEVAG SYREARIALGIARRLGHTGAVSYQDLRSFTVLADVADTDQSRALVADVLGPLRSAPDLLDFLIGYLAHGG NVNATARALNVHRNTMLTKLDRVSRATGLDIRLPDNQFTVWLAIRLDMLTEVHAAVDREAKFR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1323 | - | - | 100% (554) | transcriptional regulator, CdaR |
| M. vanbaalenii PYR-1 | Mvan_1854 | - | 5e-14 | 24.44% (540) | purine catabolism PurC domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_4407 | - | 8e-12 | 35.11% (131) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 2e-06 | 36.05% (86) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_0356 | - | 4e-13 | 22.69% (542) | purine catabolism PurC domain-containing protein |
| M. tuberculosis H37Rv | Rv2242 | - | 2e-06 | 36.05% (86) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 5e-07 | 37.21% (86) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_0825 | - | 7e-13 | 22.41% (473) | peptidase |
| M. marinum M | MMAR_3335 | - | 3e-06 | 36.05% (86) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_2195 | - | 5e-07 | 36.05% (86) | hypothetical protein MAV_2195 |
| M. smegmatis MC2 155 | MSMEG_1456 | - | 0.0 | 68.76% (557) | hypothetical protein MSMEG_1456 |
| M. thermoresistible (build 8) | TH_1338 | - | 8e-08 | 31.78% (129) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 2e-06 | 36.05% (86) | hypothetical protein MUL_1307 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3335|M.marinum_M ------------------------------------------MNDNQFS-
MUL_1307|M.ulcerans_Agy99 ------------------------------------------MNNNQFS-
Mb2266|M.bovis_AF2122/97 ------------------------------------------MNDNQLA-
Rv2242|M.tuberculosis_H37Rv ------------------------------------------MNDNQLA-
MLBr_01652|M.leprae_Br4923 ------------------------------------------MNHNHFV-
MAV_2195|M.avium_104 ------------------------------------------MNDNPFAG
TH_1338|M.thermoresistible__bu ------------------------------------------VPDNRFV-
Mvan_1323|M.vanbaalenii_PYR-1 -----------MRHDDDRMTVAGLLDESLMSGAHVLTGADRLDQQVHWVL
MSMEG_1456|M.smegmatis_MC2_155 --------MTAPPIDSGRMTVRGLLDESLMAGSRIVAGEDLLDEELTWVL
Mflv_0356|M.gilvum_PYR-GCK --------MPLTLADVIALPVVQRGRPEVLSSRRWDDTIRWVHVSDLADL
MAB_0825|M.abscessus_ATCC_1997 MAEYRLTVPITVRDLTQRADLGLVLSAGEAGAARAIKWAHAIELNDPTPY
MMAR_3335|M.marinum_M AIARLGSARSPLELLET--VPDSLLRRLKQYSGRLATEAVSAMQERLP--
MUL_1307|M.ulcerans_Agy99 AIARLGSARSPLELLET--VPDSLLRRLKQYSGRLATEAVSAMQERLP--
Mb2266|M.bovis_AF2122/97 PVARP---RSPLELLDT--VPDSLLRRLKQYSGRLATEAVSAMQERLP--
Rv2242|M.tuberculosis_H37Rv PVARP---RSPLELLDT--VPDSLLRRLKQYSGRLATEAVSAMQERLP--
MLBr_01652|M.leprae_Br4923 PAPPR---RLPLELLDT--VPDSLLRRLKQYSGRLATEAVTAMQERLP--
MAV_2195|M.avium_104 PFAKHP--RSPLETLDT--VPESVLRRLKQYSGRLATEAVSVMQDRLP--
TH_1338|M.thermoresistible__bu ---PP---QSTLEVLES--VPESVLRRLKQYSGRLATEAVHTMEERLP--
Mvan_1323|M.vanbaalenii_PYR-1 PLSEVMSRHDALDGVAVYTRPEALLGNGGTLAPLAARGATALLVDGTVPA
MSMEG_1456|M.smegmatis_MC2_155 PLNEVLSQHDRLDAVAVYARPESLTARASTLSALAARGATTLLVDGVAPP
Mflv_0356|M.gilvum_PYR-GCK STLLQGGELVLTTGAAMARSPRTYLRGLAEAGAVGVVVEVGAVVPEVPPG
MAB_0825|M.abscessus_ATCC_1997 LFGGELVMTTGLTVGLSHAEQYEYAARLSGKNVAALAFDTGTTFSEVPPG
.
MMAR_3335|M.marinum_M -----------------FFADLEASQR--ASVALVVQTAVVNFAEWMQNP
MUL_1307|M.ulcerans_Agy99 -----------------FFADLEASQR--ASVALVVQTAVVNFAEWMQNP
Mb2266|M.bovis_AF2122/97 -----------------FFADLEASQR--ASVALVVQTAVVNFVEWMHDP
Rv2242|M.tuberculosis_H37Rv -----------------FFADLEASQR--ASVALVVQTAVVNFVEWMHDP
MLBr_01652|M.leprae_Br4923 -----------------FFADLEASQR--ASVTLVVQTAVVNFVQWMQNP
MAV_2195|M.avium_104 -----------------FFADLEASQR--ASVSLVVQTAVVNFAEWMQDP
TH_1338|M.thermoresistible__bu -----------------FFADLEASQR--ASVHLVVQTAVVNFVEWMRDP
Mvan_1323|M.vanbaalenii_PYR-1 DFPTAAVPADMVVVEMAFPVGFAALNRLLAERALSQEVHAMRYATHVHAS
MSMEG_1456|M.smegmatis_MC2_155 DLG--GLPAGLVVVELGIPVGFAALNRLLAERALSQEVHVMRYSTHVHAT
Mflv_0356|M.gilvum_PYR-GCK VGG-IAEQLDLALVVLHRTVRFVEVTEAVHRMIVAEQYDVVEFDRRVHET
MAB_0825|M.abscessus_ATCC_1997 -ILAAGDELGLPILQVPVSTPFIAITRAVIDELTADELRAVQRVVDQQDV
. : . : .:. :
MMAR_3335|M.marinum_M RSDVSYTAQAFELVPQDLT------------RRIALRHTVDMVRVTMEFF
MUL_1307|M.ulcerans_Agy99 RSDVSYTAQAFELVPQDLT------------RRIALRHTVDMVRVTMEFF
Mb2266|M.bovis_AF2122/97 HSDVGYTAQAFELVPQDLT------------RRIALRQTVDMVRVTMEFF
Rv2242|M.tuberculosis_H37Rv HSDVGYTAQAFELVPQDLT------------RRIALRQTVDMVRVTMEFF
MLBr_01652|M.leprae_Br4923 HSDVSYTAQAFELVPQDLA------------RRIALRHTVDMVRVTMEFF
MAV_2195|M.avium_104 KSNVRHTAQAFELVPQDLA------------RRIALRHSVEMVRVTMEFF
TH_1338|M.thermoresistible__bu RSNVTYTMQAFEVVPQDLT------------RRIALRQTVEMVRTTMEFF
Mvan_1323|M.vanbaalenii_PYR-1 LAGLFHRGAGLQLLVREVSNLARNPAMALDARGNVVAHNGFTAETAAALT
MSMEG_1456|M.smegmatis_MC2_155 LAGLFHRGAGLQILVREVSNLARNPAVALDARGHVVAHHGLPPEAVAALA
Mflv_0356|M.gilvum_PYR-GCK FTDLSMKRASLSGIVDAAAKLLG-------EHVVLEDLSHQALVASTGIP
MAB_0825|M.abscessus_ATCC_1997 LVRATLRDGAPGVVSALSRS--------LAATVIVTATDGTLLAEAGHDA
. :
MMAR_3335|M.marinum_M EEVVPLLARSEEQLTALTVGILKYSRDLAFTAASAYADAAEAR-------
MUL_1307|M.ulcerans_Agy99 EEVVPLLARSEEQLTALTVGILKYSRDLAFTAASAYADAAEAR-------
Mb2266|M.bovis_AF2122/97 EEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEAR-------
Rv2242|M.tuberculosis_H37Rv EEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEAR-------
MLBr_01652|M.leprae_Br4923 EEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEAR-------
MAV_2195|M.avium_104 EEVVPLLARSEEQLTALTVGVLKYSRDLAFTAATAYADAAEAR-------
TH_1338|M.thermoresistible__bu EQVVPLLARSEEQVTALTAGILRYSRDLAFAAATAYADAAEAR-------
Mvan_1323|M.vanbaalenii_PYR-1 ESILPLLTADLPAAARLSAHHDTRVERFGAPGGGVWTVISTAIRLGKAFE
MSMEG_1456|M.smegmatis_MC2_155 DSVSRMLAADLPASERRHDGHDTRTQQVTGPEDSRWTCVASAIRLGKSFE
Mflv_0356|M.gilvum_PYR-GCK ADLLTDWARRSRRSPGGGAGAEPWSATDVGPRFEQWGRLVVPYAP-----
MAB_0825|M.abscessus_ATCC_1997 EHLAEITRGAFPNHSRKHASRVVADRDGYCTIQTVRAGKAERG-------
: .
MMAR_3335|M.marinum_M -----------------------------------------------GTW
MUL_1307|M.ulcerans_Agy99 -----------------------------------------------GTW
Mb2266|M.bovis_AF2122/97 -----------------------------------------------GTW
Rv2242|M.tuberculosis_H37Rv -----------------------------------------------GTW
MLBr_01652|M.leprae_Br4923 -----------------------------------------------GTW
MAV_2195|M.avium_104 -----------------------------------------------GTW
TH_1338|M.thermoresistible__bu -----------------------------------------------GAW
Mvan_1323|M.vanbaalenii_PYR-1 GWVLVVVPSAE------PGGHDLARHIVVTEQATAIIGSEMLRQHSVDEA
MSMEG_1456|M.smegmatis_MC2_155 GWVAVLVPTLAPDHADGPSKHDLARHEVLTEQATAIIGSEMLRQRSVDEA
Mflv_0356|M.gilvum_PYR-GCK --------------------ADATRAATVLERAAAALAMHRMVEQNRTGL
MAB_0825|M.abscessus_ATCC_1997 ------------------------------------------YLAVRSED
MMAR_3335|M.marinum_M DSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPAT---VVVGTPAS
MUL_1307|M.ulcerans_Agy99 DSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPAT---VVVGTPAS
Mb2266|M.bovis_AF2122/97 DSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPAT---VLVGTPAP
Rv2242|M.tuberculosis_H37Rv DSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPAT---VLVGTPAP
MLBr_01652|M.leprae_Br4923 DSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPAT---VVVGTPTP
MAV_2195|M.avium_104 DSRMEASVVDAVVRG--DTGPELLSRAAALNWDTTAPAT---VVVGTPAP
TH_1338|M.thermoresistible__bu DTRMEANVVDAVVRG--AVGPELQSQAAALNWDATAPAT---VVVGLPRP
Mvan_1323|M.vanbaalenii_PYR-1 EERARGDFVQALVHGHFSSEHDMRARADYHEIDIDSVFG---VFVAPGAV
MSMEG_1456|M.smegmatis_MC2_155 EERARGDFVQALVHGSFSSEHDMRARAEHHDIELDARFG---VFVAPGVL
Mflv_0356|M.gilvum_PYR-GCK QHQAQSGLIDDVLRGRVVDDRDAAARAQALGLRSNAQYLPVVVRVARPAE
MAB_0825|M.abscessus_ATCC_1997 ALTAAQRLLVSHAMALIAIELEKPARVADAEQRLRGAVTR--ALLADPAA
.: . : ::. . . :.
MMAR_3335|M.marinum_M AR-------DGS--DG-SERAIQDVRDAAAQHGRAALTDVHG-TWLVAIV
MUL_1307|M.ulcerans_Agy99 AR-------DGS--DG-SERAIQDVRDAAAQHGRAALTDVHG-TWLVAIV
Mb2266|M.bovis_AF2122/97 GP-------NGSNSDGDSERASQDVRDTAARHGRAALTDVHG-TWLVAIV
Rv2242|M.tuberculosis_H37Rv GP-------NGSNSDGDSERASQDVRDTAARHGRAALTDVHG-TWLVAIV
MLBr_01652|M.leprae_Br4923 NH-------DGPNGQVSSERASQEVREIAARHGRAALTDVHG-TWLVAII
MAV_2195|M.avium_104 GR-------DGSTGPGDSERASQHVRDIAAQHGRAALTDVHG-TWLVAIV
TH_1338|M.thermoresistible__bu D---------------RLEVVSQDVHHVANRHGRTALSDVHG-TWLVTIV
Mvan_1323|M.vanbaalenii_PYR-1 PR-------GVDNPAASMVRLARYAANVAPDPAVRSYVTVLG-DVLVVVR
MSMEG_1456|M.smegmatis_MC2_155 PR-------GPDSPTTPMVRLARYAAGVAAHPSVHAYVTVIG-DVLVVVR
Mflv_0356|M.gilvum_PYR-GCK ID-------DPVAGHRRNVAVLDAVAHTVNACGHTGLFSLRGDGEVGAVL
MAB_0825|M.abscessus_ATCC_1997 ADRSVLRYFGFDPDTEVVVVLLCNVGSVLPGELHIDRQLARGGPYLMASV
. * : .
MMAR_3335|M.marinum_M SG----------HLSPTDKVFKDLLEAFSDGP---VVIGPTAPMLTAAYH
MUL_1307|M.ulcerans_Agy99 SG----------HLSPTDKVFKDLLEAFSDGP---VVIGPTAPMLTAAYH
Mb2266|M.bovis_AF2122/97 SG----------QLSPTEKFLKDLLAAFADAP---VVIGPTAPMLTAAHR
Rv2242|M.tuberculosis_H37Rv SG----------QLSPTEKFLKDLLAAFADAP---VVIGPTAPMLTAAHR
MLBr_01652|M.leprae_Br4923 SG----------QLAPTDKFFSDLLHAFSDGP---VVIGPTAPMLTAAYH
MAV_2195|M.avium_104 SG----------QLSPTDKFLGDLLEAFSDGP---VVVGPTAPMLTAAYH
TH_1338|M.thermoresistible__bu SG----------ALSPTDRFLTDLLDVFADGP---VVLGPTAPTLSAAYR
Mvan_1323|M.vanbaalenii_PYR-1 SLRGADDTAMRKEMTRYAEAMADELQNRRGTP---AAVAYSRPARGAQEV
MSMEG_1456|M.smegmatis_MC2_155 TLRGEDAAAMRSEMAEYAEAMSGELQRRRGLP---APVAYGRPALGAGEV
Mflv_0356|M.gilvum_PYR-GCK SLKDSRTRSVDQALGALARRIHTEIRRVDGSDRVVVTLGPSARNVTDAIA
MAB_0825|M.abscessus_ATCC_1997 SG------EIVVVLAAKNVGRASELHRSLGTALGRTICAGISRRVRLDEV
: : : . . .
MMAR_3335|M.marinum_M SASEAISGMNAVAGWRGAPRPVLARELLPERALMG---DASAIV----AL
MUL_1307|M.ulcerans_Agy99 SASEAISGMNAVAGWRGASRPVLARELLPERALMG---DASAIV----AL
Mb2266|M.bovis_AF2122/97 SASEAISGMNAVAGWRGAPRPVLARELLPERALMG---DASAIV----AL
Rv2242|M.tuberculosis_H37Rv SASEAISGMNAVAGWRGAPRPVLARELLPERALMG---DASAIV----AL
MLBr_01652|M.leprae_Br4923 SASEAVSGMNAVAGWSGAPRPVQARELLPERALMG---DASAIV----AL
MAV_2195|M.avium_104 SASEAISGMNAVGGWRGAPRPVLARELLPERALMG---DASAIV----AL
TH_1338|M.thermoresistible__bu SATEAIAGMNAVAGWSGAPRPVPARELLPERALLG---DQTAIA----AL
Mvan_1323|M.vanbaalenii_PYR-1 AGSYREARIALGIARRLGHTGAVSYQDLRSFTVLADVADTDQSR----AL
MSMEG_1456|M.smegmatis_MC2_155 RESYREARVALGIARRLHRTGATSYQQLRGFTVLAQVAETEDSR----QL
Mflv_0356|M.gilvum_PYR-GCK GLAEAIDTAEVALSLRGDVRDFYRTSDIRLRGLISLLRDDPRIRRFAETE
MAB_0825|M.abscessus_ATCC_1997 PLGLHQARS---VARAHPDGRIAEFDELDIYGVLLGGRDRGELA----VL
. . : :: :
MMAR_3335|M.marinum_M HTDVMRPL-ADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKR
MUL_1307|M.ulcerans_Agy99 HTDVMRPL-ADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKR
Mb2266|M.bovis_AF2122/97 HTDVMRPL-ADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKR
Rv2242|M.tuberculosis_H37Rv HTDVMRPL-ADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKR
MLBr_01652|M.leprae_Br4923 HTDVMLPL-ADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKR
MAV_2195|M.avium_104 HTDVMGPL-ADAGPTLIETLDAFLDSGGAIEACARKLFVHPNTVRYRLKR
TH_1338|M.thermoresistible__bu ESEVMRPL-ADAGPTLTETLDAFLESGGAIEACARRLFVHPNTVRYRLRR
Mvan_1323|M.vanbaalenii_PYR-1 VADVLGPL-RSA-PDLLDFLIGYLAHGGNVNATARALNVHRNTMLTKLDR
MSMEG_1456|M.smegmatis_MC2_155 VRDVLGPL-RSS-PDLLETLEAYLSEGGNINATARTLNVHRNTMLAKLDR
Mflv_0356|M.gilvum_PYR-GCK LRALLAHD-AGAEPSNISVLREYLRLAGNKSALAERLHMSRPALYKRLRG
MAB_0825|M.abscessus_ATCC_1997 AQSVAPLLGTGADTTLLDTLESFLACNGQMETAALNLGVHRHTMRNRIAR
: .: . . * :* * .: * * : :: ::
MMAR_3335|M.marinum_M ITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVRR
MUL_1307|M.ulcerans_Agy99 ITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPPSGAANNTITPVPLPVRR
Mb2266|M.bovis_AF2122/97 ITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH-----------------
Rv2242|M.tuberculosis_H37Rv ITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH-----------------
MLBr_01652|M.leprae_Br4923 ITDFTGHDPTLPRDAYVLRVAATVGKLNYPTHH-----------------
MAV_2195|M.avium_104 ITDFTGRDPMQPRDAYVLRVAATVGQLNYPTHPPSAAGAAMPAVPLPVNG
TH_1338|M.thermoresistible__bu IAEITGRDPAVPRDAYVLRVAVSVSRLTRQSYQSSTVNPDLGSTAGWRGQ
Mvan_1323|M.vanbaalenii_PYR-1 VSRATGLDIRLPDNQFTVWLAIRLDMLTEVHAAVDREAKFR---------
MSMEG_1456|M.smegmatis_MC2_155 ISRMLGMDVRDPEHQFTVWLAIRLDLLDEVHSAVEREASFR---------
Mflv_0356|M.gilvum_PYR-GCK IEDALGVDLDDGESMTSLHVAVMVLDSLTGSG------------------
MAB_0825|M.abscessus_ATCC_1997 IAALLDCDLHSADTRAALWIAIRARALLG---------------------
: . * : :*
MMAR_3335|M.marinum_M GTEGP---
MUL_1307|M.ulcerans_Agy99 GTEGP---
Mb2266|M.bovis_AF2122/97 --------
Rv2242|M.tuberculosis_H37Rv --------
MLBr_01652|M.leprae_Br4923 --------
MAV_2195|M.avium_104 AARGQSGG
TH_1338|M.thermoresistible__bu AAGGHRAM
Mvan_1323|M.vanbaalenii_PYR-1 --------
MSMEG_1456|M.smegmatis_MC2_155 --------
Mflv_0356|M.gilvum_PYR-GCK --------
MAB_0825|M.abscessus_ATCC_1997 --------