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SFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMT AFHDQFVQALRASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVQSMFLGTGG SSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWV QYGFNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAASINQF INTEINWIRGFLPPLPPISPPGFPSLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1172c | PE12 | - | 100% (308) | PE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3595c | PE_PGRS59 | 2e-39 | 50.00% (176) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv2162c | PE_PGRS38 | 3e-39 | 50.29% (173) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1205c | PE12 | 1e-171 | 99.68% (308) | PE family protein |
| M. gilvum PYR-GCK | Mflv_2738 | - | 2e-06 | 22.46% (236) | hypothetical protein Mflv_2738 |
| M. leprae Br4923 | MLBr_01183 | - | 3e-10 | 38.04% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_2679 | - | 4e-14 | 31.10% (164) | hypothetical protein MAB_2679 |
| M. marinum M | MMAR_4280 | - | 2e-93 | 60.33% (300) | PE family protein |
| M. avium 104 | MAV_1346 | - | 3e-22 | 38.14% (215) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5127 | - | 2e-08 | 25.76% (132) | hypothetical protein MSMEG_5127 |
| M. thermoresistible (build 8) | TH_3064 | - | 2e-32 | 34.50% (229) | PUTATIVE putative PE family protein |
| M. ulcerans Agy99 | MUL_1019 | - | 2e-90 | 58.63% (307) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_3794 | - | 2e-06 | 23.29% (249) | hypothetical protein Mvan_3794 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2738|M.gilvum_PYR-GCK ----MGNEMHASIRAALAAGVTTLTASALAFAPPPQPP------------
Mvan_3794|M.vanbaalenii_PYR-1 --------MNVSARAALAAGVTALTGGALMFTPSVLPATMSTVEVVRPVA
Rv1172c|M.tuberculosis_H37Rv -----MS-FVFAAPEALAAAAADMAG------------------------
Mb1205c|M.bovis_AF2122/97 -----MS-FVFAAPEALAAAAADMAG------------------------
MMAR_4280|M.marinum_M -----MS-YVAAVPEALTAAASDVAG------------------------
MUL_1019|M.ulcerans_Agy99 -----MS-YVATVPEALTAAASDAAG------------------------
MLBr_01183|M.leprae_Br4923 -----MPLFLNAEPQALTAAANTLEG------------------------
MAV_1346|M.avium_104 -----MS-FVTTRPEALLAVASMLEG------------------------
MAB_2679|M.abscessus_ATCC_1997 -MDRTANPLFKAGMAAITATALIVAPAVTPPTRQSIPLP-----------
MSMEG_5127|M.smegmatis_MC2_155 -MTVSVRAYLMAGAAAATATTIALTSVQVTPPDVVVPAQP----------
TH_3064|M.thermoresistible__bu VAAVGAAAVAFAPVQALPPDIAVTAEQPVLDASASREAVALLAAVQG---
: * .
Mflv_2738|M.gilvum_PYR-GCK -AAQALSVQPLS-----IASEMVSAASFTAG----STRILPVTDPRALAA
Mvan_3794|M.vanbaalenii_PYR-1 FAADGTPITPVSDDDVRAALELIGNLGSVAGPRKVTVRLGGHDHPEAARA
Rv1172c|M.tuberculosis_H37Rv ---------------------------------------IGSTLNAANVV
Mb1205c|M.bovis_AF2122/97 ---------------------------------------IGSTLNAANVV
MMAR_4280|M.marinum_M ---------------------------------------IGTTISSANAA
MUL_1019|M.ulcerans_Agy99 ---------------------------------------IGTTISSANAA
MLBr_01183|M.leprae_Br4923 ---------------------------------------LSAATVASNAA
MAV_1346|M.avium_104 ---------------------------------------LGSSMDAQNAA
MAB_2679|M.abscessus_ATCC_1997 -DIRSASVRLSSLAFTPRAAEVPASPLAALKLSLSPASAAPASPLKRAPL
MSMEG_5127|M.smegmatis_MC2_155 -------------------------------TAPQPELTQAMVDLLAAAR
TH_3064|M.thermoresistible__bu ----------------------------------LAVRPASPPVAPTAPT
Mflv_2738|M.gilvum_PYR-GCK LTAFTQPWPGTPSDAADPTDLATVTTADEPLEDPVALNAASDVIDTVYAF
Mvan_3794|M.vanbaalenii_PYR-1 ILPTARVVDAGGTDPAS-VDAPAAAADGQALDEPVAQNAASDLIDTVYSI
Rv1172c|M.tuberculosis_H37Rv AAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQAL
Mb1205c|M.bovis_AF2122/97 AAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQAL
MMAR_4280|M.marinum_M ASAPTTGVLAAAGDQVSAQVAALFSSHGEIYQRLSSQLST-FHDQFAAAL
MUL_1019|M.ulcerans_Agy99 ASAPTTGVLAAAGDQVSAQVAALFSSHGEIYQRLSSQLST-FHDQFAAAL
MLBr_01183|M.leprae_Br4923 AAQLTTEIAPPAADDVSILLAHFFSGHGRQYQAHASQGAT-NHQDLIQSL
MAV_1346|M.avium_104 AAAPTTSIAPAAADEVSALQAAQFSAYGTWYQQVSAQAKA-IHQTLVQNL
MAB_2679|M.abscessus_ATCC_1997 GQLATAVQPRAAAAPLPTPVSAPTQPDAATASSPVVASSLTNGIDQAYQF
MSMEG_5127|M.smegmatis_MC2_155 RTTITIPVPPDAPRVAPPHGNAAPDAQATASGDVTVQNAASDFVVDAWEA
TH_3064|M.thermoresistible__bu PDEVQAAVTAIQELAAPGAPATTAAADSAIEVGTAAFPGAANAIKDVYNL
Mflv_2738|M.gilvum_PYR-GCK TRYWANYVSLELGPWLINWVPFGYLISDQILIWYPNFVLPVVDSFVYDFL
Mvan_3794|M.vanbaalenii_PYR-1 SRYWANYVSLELGPWLINWIPFGYLISDQIYIWYPDFVLPVVDSFVYDFL
Rv1172c|M.tuberculosis_H37Rv RASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGG-------
Mb1205c|M.bovis_AF2122/97 RASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGG-------
MMAR_4280|M.marinum_M NTSANSYASAEANAAKTLLSAVNSPAEKLLGQPLMGQGGIV---------
MUL_1019|M.ulcerans_Agy99 NTSANSYASAEANAAKTLLSAVNSPAEKLLGQPLMGQGGIV---------
MLBr_01183|M.leprae_Br4923 LTSSSAYAGTETAN------------------------------------
MAV_1346|M.avium_104 DTNADSYGATEAANRVNTSAAALQGLAPNVIPNAAPAADPPPA-------
MAB_2679|M.abscessus_ATCC_1997 IQYWVDYGVDLAQWGAGFVPVIGGLVSAQIGIVYDNLVRPIANSFVYNLV
MSMEG_5127|M.smegmatis_MC2_155 AVPWIDYGVGLVDGALG-WVPGLAIVGNQVSLLWTYLGYPVANSVVLDLV
TH_3064|M.thermoresistible__bu IEPYVAWG-VEVAQWAVGWVPWVGLLSGQIGIFYTFGEAIVYS-------
:
Mflv_2738|M.gilvum_PYR-GCK DPVVNDPLNLEVW-------------------------------AQGIGS
Mvan_3794|M.vanbaalenii_PYR-1 DPVVNDPLNLNVW-------------------------------LDGIGD
Rv1172c|M.tuberculosis_H37Rv --GSNALSRVQSM-------------------------------FLGTGG
Mb1205c|M.bovis_AF2122/97 --GSNALSRVHSM-------------------------------FLGTGG
MMAR_4280|M.marinum_M ---ANAVSQVQSV-------------------------------FAGAG-
MUL_1019|M.ulcerans_Agy99 ---ANAVSQVQSV-------------------------------FAGAG-
MLBr_01183|M.leprae_Br4923 ---HDSL-------------------------------------------
MAV_1346|M.avium_104 --GTTSLGTSIGW-------------------------------AQNVGA
MAB_2679|M.abscessus_ATCC_1997 DPILNDPSFSNIVNSFGRFGSDIVNSVINFAWAEARYFLPPLPPLPGLAL
MSMEG_5127|M.smegmatis_MC2_155 APVVNAPLNLDVW-------------------------------ANGFGA
TH_3064|M.thermoresistible__bu -VVFNVADWIGGTVG------------------------------FGEGL
Mflv_2738|M.gilvum_PYR-GCK IIDTAVAGVRNGVTAEIQYILDFGWFPFPLPPLPSFPVPGAAGASAESAD
Mvan_3794|M.vanbaalenii_PYR-1 IINTALTGVYNGVVGEIQYALSFDWFPIPLPPLPPFP-PLPIFDAADSAP
Rv1172c|M.tuberculosis_H37Rv SSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPAL
Mb1205c|M.bovis_AF2122/97 SSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPAL
MMAR_4280|M.marinum_M SNALG-------ANASMLALAPTGGAATAAASGSLLG-PIASAAAAPAAI
MUL_1019|M.ulcerans_Agy99 SNALG-------ANASMLALAPTGGAATAAASGSLLG-PIASAAAAPAAI
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 AASDF-------ITLGEGQFAPVPGAAGIPNFNPGLT--AATTAGPPAPA
MAB_2679|M.abscessus_ATCC_1997 QTTTDANGAAPTSVHEALVPFTKAFKDAEAHFAEALGLTKPDPKSAALEK
MSMEG_5127|M.smegmatis_MC2_155 VASTTANSLVNTGVAEFNYFFGWLIPPVALTTPTETLAFDATVGADLLKQ
TH_3064|M.thermoresistible__bu ANIAAATSQAVTDLIRDEINWVRSFFPPLPPLPPVLPAALPMSLPTSLPT
Mflv_2738|M.gilvum_PYR-GCK ADVQLAS--VDEADAAGAVEDAVEGAEGGAAEAVEVDG---DDIVAQKPA
Mvan_3794|M.vanbaalenii_PYR-1 TEVTLASSETDGDETGATAIEATDSDDTDAVTDVPVDDPITETVVTPAPE
Rv1172c|M.tuberculosis_H37Rv AAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIG-------ILAPQ
Mb1205c|M.bovis_AF2122/97 AAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIG-------ILAPQ
MMAR_4280|M.marinum_M LPVSVATAIQNFYLAVEPWVQYGFNLASWAVGWVPWIG-------ILAPQ
MUL_1019|M.ulcerans_Agy99 LPVSVATAIQNFCLAVEPWVQYGFNLASWAVGWVPWIG-------ILAPQ
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 APAAAAGAPVLASMGRGPSIGGLSVPPSWAPGGVAPAA-------NATPA
MAB_2679|M.abscessus_ATCC_1997 TGTAAQTGESLKETTGESVQEEGKTAETGAATGTKEALDRKESAEGKASA
MSMEG_5127|M.smegmatis_MC2_155 ARAAVTSLVEPAEGAEAAEASEAPKAPESLESPEKPETKTPDAPAAEFSA
TH_3064|M.thermoresistible__bu SEAHPAQQVGIAKAGAAAEVAGSPTATTVVEGDLPADEAPEPPAQAQRQP
Mflv_2738|M.gilvum_PYR-GCK DVSGEAVDEALVEEESVEEESVDVVDEESVEAVDDETDQVEETVDEESAE
Mvan_3794|M.vanbaalenii_PYR-1 DAAGEEAPAGTAAEDEPE-TPVEDVEESVEDAVEEDADEASGETGAETPA
Rv1172c|M.tuberculosis_H37Rv INFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALT-------NIETATAAS
Mb1205c|M.bovis_AF2122/97 INFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALT-------NIETATAAS
MMAR_4280|M.marinum_M INFFYYLFEPIVQSGLFNTLDWLDGTITFSQGLS-------NFWSATTAS
MUL_1019|M.ulcerans_Agy99 INFFYYLFEPIVQSGLFNTLDWLDGTVTFSQGLSNFSQGLSNFWSATTAS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 Q---------LVGAGFTSAAPDTAPVTAVPGGVP---------SMATAGR
MAB_2679|M.abscessus_ATCC_1997 NDKATAVAEKTKAGDKATTESREPVTTATEAAKESTKDSVKDAAVPGVAA
MSMEG_5127|M.smegmatis_MC2_155 PAGTTENTASGVTENAENTEVVEDTTTPTKADTSTKAPVKPVRTITKNIK
TH_3064|M.thermoresistible__bu VQRGALLAETDPVEDDSSAPDAGESPAPGVDVRPGPRPGTALRDSLQEVA
Mflv_2738|M.gilvum_PYR-GCK DGATTDDEPTDEDAPA---GSDSGDDTSGSETE-----------------
Mvan_3794|M.vanbaalenii_PYR-1 PAEDTGADGPGTDEPASEPASDEKDSVAASASGD----------------
Rv1172c|M.tuberculosis_H37Rv INQFINTEINWIRGFLPPLPPISPPGFPSLP-------------------
Mb1205c|M.bovis_AF2122/97 INQFINTEINWIRGFLPPLPPISPPGFPSLP-------------------
MMAR_4280|M.marinum_M VNQFIQTEINWIRHFFPPFPPLP---F-----------------------
MUL_1019|M.ulcerans_Agy99 VNQFIQTEINWIRNFFPPFPPLP---F-----------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 GGYGLGAPRYGVKPTVMPKPAI----------------------------
MAB_2679|M.abscessus_ATCC_1997 DSDAASGNLTKGTLAAKETGNQQQSATDGKPSPSSAPADKPDKPVKPKVP
MSMEG_5127|M.smegmatis_MC2_155 RDLKKATAGLRGVVKDIRDGLVKPKKPATKPSKKAEPAKKAEPSKQSASE
TH_3064|M.thermoresistible__bu RAATASVEXXXXGPPWPAGPAMPAPTGPPCSSPAGSAPPAPCAAFITCSI
Mflv_2738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3794|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4280|M.marinum_M --------------------------------------------------
MUL_1019|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_2679|M.abscessus_ATCC_1997 AASTTEHGSISAQGIVRGPVSQSTSGQSGPSASTPKTADSKVSSSGASGF
MSMEG_5127|M.smegmatis_MC2_155 SSSSDSDD------------------------------------------
TH_3064|M.thermoresistible__bu SELNIPVCPPSPPAP-----------------------------------
Mflv_2738|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3794|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4280|M.marinum_M --------------------------------------------------
MUL_1019|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
MAB_2679|M.abscessus_ATCC_1997 QTSDTGTPESKMSDTKTATGTTAGTKATETKPKAAETKPSDAKSSGSTTS
MSMEG_5127|M.smegmatis_MC2_155 --------------------------------------------------
TH_3064|M.thermoresistible__bu --------------------------------------------------
Mflv_2738|M.gilvum_PYR-GCK ---------------------------------------
Mvan_3794|M.vanbaalenii_PYR-1 ---------------------------------------
Rv1172c|M.tuberculosis_H37Rv ---------------------------------------
Mb1205c|M.bovis_AF2122/97 ---------------------------------------
MMAR_4280|M.marinum_M ---------------------------------------
MUL_1019|M.ulcerans_Agy99 ---------------------------------------
MLBr_01183|M.leprae_Br4923 ---------------------------------------
MAV_1346|M.avium_104 ---------------------------------------
MAB_2679|M.abscessus_ATCC_1997 GTKSPGTTAHDSANKPSASASSAAKSGGEGSKSSSGSHR
MSMEG_5127|M.smegmatis_MC2_155 ---------------------------------------
TH_3064|M.thermoresistible__bu ---------------------------------------