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MSYVAAVPEALTAAASDVAGIGTTISSANAAASAPTTGVLAAAGDQVSAQVAALFSSHGEIYQRLSSQLS TFHDQFAAALNTSANSYASAEANAAKTLLSAVNSPAEKLLGQPLMGQGGIVANAVSQVQSVFAGAGSNAL GANASMLALAPTGGAATAAASGSLLGPIASAAAAPAAILPVSVATAIQNFYLAVEPWVQYGFNLASWAVG WVPWIGILAPQINFFYYLFEPIVQSGLFNTLDWLDGTITFSQGLSNFWSATTASVNQFIQTEINWIRHFF PPFPPLPF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4280 | - | - | 100% (288) | PE family protein |
| M. marinum M | MMAR_0572 | - | 7e-35 | 47.19% (178) | PE-PGRS family protein |
| M. marinum M | MMAR_0755 | - | 1e-34 | 45.98% (174) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1205c | PE12 | 5e-93 | 60.00% (300) | PE family protein |
| M. gilvum PYR-GCK | Mflv_0326 | - | 3e-08 | 35.79% (95) | PE domain-containing protein |
| M. tuberculosis H37Rv | Rv1172c | PE12 | 1e-93 | 60.33% (300) | PE family protein |
| M. leprae Br4923 | MLBr_01183 | - | 1e-12 | 40.45% (89) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_2679 | - | 2e-16 | 35.19% (162) | hypothetical protein MAB_2679 |
| M. avium 104 | MAV_1346 | - | 6e-21 | 36.08% (194) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_0618 | - | 1e-08 | 36.84% (95) | PE family protein |
| M. thermoresistible (build 8) | TH_3064 | - | 5e-33 | 36.45% (214) | PUTATIVE putative PE family protein |
| M. ulcerans Agy99 | MUL_1019 | - | 1e-157 | 95.93% (295) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_0414 | - | 8e-09 | 37.89% (95) | PE domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4280|M.marinum_M ----------------------------------------------MSYV
MUL_1019|M.ulcerans_Agy99 ----------------------------------------------MSYV
Mb1205c|M.bovis_AF2122/97 ----------------------------------------------MSFV
Rv1172c|M.tuberculosis_H37Rv ----------------------------------------------MSFV
Mflv_0326|M.gilvum_PYR-GCK -----------------------------------------------MTL
Mvan_0414|M.vanbaalenii_PYR-1 -----------------------------------------------MTL
MSMEG_0618|M.smegmatis_MC2_155 -----------------------------------------------MTL
MLBr_01183|M.leprae_Br4923 ---------------------------------------------MPLFL
MAV_1346|M.avium_104 ---------------------------------------------MS-FV
TH_3064|M.thermoresistible__bu -------------------VAAVGAAAVAFAPVQALPPDIAVTAEQPVLD
MAB_2679|M.abscessus_ATCC_1997 MDRTANPLFKAGMAAITATALIVAPAVTPPTRQSIPLPDIRSASVRLSSL
MMAR_4280|M.marinum_M AAVPEALTAAASDVAGIGTTISSANAAASAPTT--------GVLAAAGDQ
MUL_1019|M.ulcerans_Agy99 ATVPEALTAAASDAAGIGTTISSANAAASAPTT--------GVLAAAGDQ
Mb1205c|M.bovis_AF2122/97 FAAPEALAAAAADMAGIGSTLNAANVVAAVPTT--------GVLAAAADE
Rv1172c|M.tuberculosis_H37Rv FAAPEALAAAAADMAGIGSTLNAANVVAAVPTT--------GVLAAAADE
Mflv_0326|M.gilvum_PYR-GCK RVVPEGLTAASAAVEALTARMAAAHAAAAPLVT--------AVLPPAADA
Mvan_0414|M.vanbaalenii_PYR-1 RVVPEGLTAAGAAVEALTARMAAAHAAAAPVVT--------AVLPPAADV
MSMEG_0618|M.smegmatis_MC2_155 RVVPEGLTAASSAVEALTARLAAAHAAAAPMIS--------TVLPPAADA
MLBr_01183|M.leprae_Br4923 NAEPQALTAAANTLEGLSAATVASNAAAAQLTT--------EIAPPAADD
MAV_1346|M.avium_104 TTRPEALLAVASMLEGLGSSMDAQNAAAAAPTT--------SIAPAAADE
TH_3064|M.thermoresistible__bu ASASREAVALLAAVQGLAVRPASPPVAPTAPTP--------DEVQAAVTA
MAB_2679|M.abscessus_ATCC_1997 AFTPRAAEVPASPLAALKLSLSPASAAPASPLKRAPLGQLATAVQPRAAA
.. . .: . ...: .
MMAR_4280|M.marinum_M VSAQVAALFSSHGEIYQRLSSQLST-FHDQF-------------------
MUL_1019|M.ulcerans_Agy99 VSAQVAALFSSHGEIYQRLSSQLST-FHDQF-------------------
Mb1205c|M.bovis_AF2122/97 VSTQVAALLSAHAQGYQQLSRQMMTAFHDQF-------------------
Rv1172c|M.tuberculosis_H37Rv VSTQVAALLSAHAQGYQQLSRQMMTAFHDQF-------------------
Mflv_0326|M.gilvum_PYR-GCK VSLQTATGLSANGVEHQSIAARGVE-ELGRS-------------------
Mvan_0414|M.vanbaalenii_PYR-1 VSLQAATGFSARAAEHQSVAAQGVE-ELGRS-------------------
MSMEG_0618|M.smegmatis_MC2_155 VSLQTAAGFSANGAQQSAVAAQGVE-ELGRS-------------------
MLBr_01183|M.leprae_Br4923 VSILLAHFFSGHGRQYQAHASQGAT-NHQDL-------------------
MAV_1346|M.avium_104 VSALQAAQFSAYGTWYQQVSAQAKA-IHQTL-------------------
TH_3064|M.thermoresistible__bu IQELAAPGAPATTAAADSAIEVGTAAFPGAANAIKDVYNLIEPY------
MAB_2679|M.abscessus_ATCC_1997 APLPTPVSAPTQPDAATASSPVVASSLTNGIDQAYQFIQYWVDYGVDLAQ
. .
MMAR_4280|M.marinum_M --------------------------------------------------
MUL_1019|M.ulcerans_Agy99 --------------------------------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3064|M.thermoresistible__bu ----------------------------------------------VAWG
MAB_2679|M.abscessus_ATCC_1997 WGAGFVPVIGGLVSAQIGIVYDNLVRPIANSFVYNLVDPILNDPSFSNIV
MMAR_4280|M.marinum_M ---------------------------------AAALNTSANSYASAEAN
MUL_1019|M.ulcerans_Agy99 ---------------------------------AAALNTSANSYASAEAN
Mb1205c|M.bovis_AF2122/97 ---------------------------------VQALRASADAYATAEAS
Rv1172c|M.tuberculosis_H37Rv ---------------------------------VQALRASADAYATAEAS
Mflv_0326|M.gilvum_PYR-GCK ---------------------------------GVGVGDSAASYVSGDAM
Mvan_0414|M.vanbaalenii_PYR-1 ---------------------------------GIAVGESAASYAGGDAM
MSMEG_0618|M.smegmatis_MC2_155 ---------------------------------GVGVGESGVSYATGDAQ
MLBr_01183|M.leprae_Br4923 ---------------------------------IQSLLTSSSAYAGTETA
MAV_1346|M.avium_104 ---------------------------------VQNLDTNADSYGATEAA
TH_3064|M.thermoresistible__bu VEVAQWAVGWVPWVGLLSGQIGIFYTFGEAIVYSVVFNVADWIGGTVGFG
MAB_2679|M.abscessus_ATCC_1997 NSFGRFGSDIVNSVINFAWAEARYFLPPLPPLPGLALQTTTDANGAAPTS
.
MMAR_4280|M.marinum_M AAKTLLSAVNSPAEKLLGQPLMGQGGIV---ANAVSQVQSVFAG------
MUL_1019|M.ulcerans_Agy99 AAKTLLSAVNSPAEKLLGQPLMGQGGIV---ANAVSQVQSVFAG------
Mb1205c|M.bovis_AF2122/97 AAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVHSMFLG------
Rv1172c|M.tuberculosis_H37Rv AAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVQSMFLG------
Mflv_0326|M.gilvum_PYR-GCK AATSYLIARG----------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 AASSYLIARG----------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 AAASYLTARGL---------------------------------------
MLBr_01183|M.leprae_Br4923 N------------------------------HDSL---------------
MAV_1346|M.avium_104 NRVNTSAAALQGLAPNVIPNAAPAADPPPAGTTSLGTSIGWAQN------
TH_3064|M.thermoresistible__bu EGLANIAAATSQAVTDLIRDEINWVRSFFPPLPPLPPVLPAALP------
MAB_2679|M.abscessus_ATCC_1997 VHEALVPFTKAFKDAEAHFAEALGLTKPDPKSAALEKTGTAAQTGESLKE
MMAR_4280|M.marinum_M ------------------------AG-SNALG------ANAS-MLALAPT
MUL_1019|M.ulcerans_Agy99 ------------------------AG-SNALG------ANAS-MLALAPT
Mb1205c|M.bovis_AF2122/97 ------------------------TGGSSALGGSAAANAAASGALQLQPT
Rv1172c|M.tuberculosis_H37Rv ------------------------TGGSSALGGSAAANAAASGALQLQPT
Mflv_0326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 ------------------------VG-------AAASDFITLGEGQFAPV
TH_3064|M.thermoresistible__bu ------------------------MSLPTSLPTSEAHPAQQVGIAKAGAA
MAB_2679|M.abscessus_ATCC_1997 TTGESVQEEGKTAETGAATGTKEALDRKESAEGKASANDKATAVAEKTKA
MMAR_4280|M.marinum_M GGAATAAASGSLLG-PIASAAAAPAAILPVSVATAIQNFYLAVEPWVQYG
MUL_1019|M.ulcerans_Agy99 GGAATAAASGSLLG-PIASAAAAPAAILPVSVATAIQNFCLAVEPWVQYG
Mb1205c|M.bovis_AF2122/97 GGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYG
Rv1172c|M.tuberculosis_H37Rv GGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYG
Mflv_0326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 PGAAGIPNFNPGLTAATTAGPPAPAAPAAAAGAPVLA--SMGRGPSIGGL
TH_3064|M.thermoresistible__bu AEVAGSPTATTVVEGDLPADEAPEPPAQAQRQPVQRGALLAETDPVEDDS
MAB_2679|M.abscessus_ATCC_1997 GDKATTESREPVTTATEAAKESTKDSVKDAAVPGVAADSDAASGNLTKGT
MMAR_4280|M.marinum_M FNLASWAVGWVPWIGILAPQINFFYYLFEPIVQSGLFNTLDWLDGTITFS
MUL_1019|M.ulcerans_Agy99 FNLASWAVGWVPWIGILAPQINFFYYLFEPIVQSGLFNTLDWLDGTVTFS
Mb1205c|M.bovis_AF2122/97 FNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFS
Rv1172c|M.tuberculosis_H37Rv FNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFS
Mflv_0326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 SVPPSWAPGGVAPAANATPAQ---------LVGAGFTSAAPDTAPVTAVP
TH_3064|M.thermoresistible__bu SAPDAGESPAPGVDVRPGPRPGTALRDSLQEVARAATASVEXXXXGPPWP
MAB_2679|M.abscessus_ATCC_1997 LAAKETGNQQQSATDGKPSPSSAPADKPDKPVKPKVPAASTTEHGSISAQ
MMAR_4280|M.marinum_M Q----GLS-------NFWSATTASVNQFIQTEINWIRHFFPPFPPLP---
MUL_1019|M.ulcerans_Agy99 Q----GLSNFSQGLSNFWSATTASVNQFIQTEINWIRNFFPPFPPLP---
Mb1205c|M.bovis_AF2122/97 Q----ALT-------NIETATAASINQFINTEINWIRGFLPPLPPISPPG
Rv1172c|M.tuberculosis_H37Rv Q----ALT-------NIETATAASINQFINTEINWIRGFLPPLPPISPPG
Mflv_0326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 G----GVP---------SMATAGRGGYGLGAPRYGVKPTVMPKPAI----
TH_3064|M.thermoresistible__bu AGPAMPAPTGPPCSSPAGSAPPAPCAAFITCSISELNIPVCPPSPPAP--
MAB_2679|M.abscessus_ATCC_1997 GIVRGPVSQSTSGQSGPSASTPKTADSKVSSSGASGFQTSDTGTPESKMS
MMAR_4280|M.marinum_M F-------------------------------------------------
MUL_1019|M.ulcerans_Agy99 F-------------------------------------------------
Mb1205c|M.bovis_AF2122/97 FPSLP---------------------------------------------
Rv1172c|M.tuberculosis_H37Rv FPSLP---------------------------------------------
Mflv_0326|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3064|M.thermoresistible__bu --------------------------------------------------
MAB_2679|M.abscessus_ATCC_1997 DTKTATGTTAGTKATETKPKAAETKPSDAKSSGSTTSGTKSPGTTAHDSA
MMAR_4280|M.marinum_M --------------------------
MUL_1019|M.ulcerans_Agy99 --------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------
Mflv_0326|M.gilvum_PYR-GCK --------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------
MLBr_01183|M.leprae_Br4923 --------------------------
MAV_1346|M.avium_104 --------------------------
TH_3064|M.thermoresistible__bu --------------------------
MAB_2679|M.abscessus_ATCC_1997 NKPSASASSAAKSGGEGSKSSSGSHR