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SYVATVPEALTAAASDAAGIGTTISSANAAASAPTTGVLAAAGDQVSAQVAALFSSHGEIYQRLSSQLST FHDQFAAALNTSANSYASAEANAAKTLLSAVNSPAEKLLGQPLMGQGGIVANAVSQVQSVFAGAGSNALG ANASMLALAPTGGAATAAASGSLLGPIASAAAAPAAILPVSVATAIQNFCLAVEPWVQYGFNLASWAVGW VPWIGILAPQINFFYYLFEPIVQSGLFNTLDWLDGTVTFSQGLSNFSQGLSNFWSATTASVNQFIQTEIN WIRNFFPPFPPLPF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1019 | - | - | 100% (295) | PE family protein |
| M. ulcerans Agy99 | MUL_3292 | - | 6e-33 | 44.79% (192) | PE-PGRS family protein |
| M. ulcerans Agy99 | MUL_3247 | - | 2e-32 | 44.81% (183) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1205c | PE12 | 6e-90 | 58.31% (307) | PE family protein |
| M. gilvum PYR-GCK | Mflv_2738 | - | 2e-08 | 29.61% (152) | hypothetical protein Mflv_2738 |
| M. tuberculosis H37Rv | Rv1172c | PE12 | 2e-90 | 58.63% (307) | PE family protein |
| M. leprae Br4923 | MLBr_01183 | - | 5e-12 | 41.67% (84) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_2679 | - | 2e-14 | 34.91% (169) | hypothetical protein MAB_2679 |
| M. marinum M | MMAR_4280 | - | 1e-157 | 95.93% (295) | PE family protein |
| M. avium 104 | MAV_1346 | - | 3e-21 | 36.60% (194) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_0618 | - | 3e-08 | 35.79% (95) | PE family protein |
| M. thermoresistible (build 8) | TH_3064 | - | 1e-30 | 35.29% (221) | PUTATIVE putative PE family protein |
| M. vanbaalenii PYR-1 | Mvan_0414 | - | 2e-08 | 36.84% (95) | PE domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1019|M.ulcerans_Agy99 ----------------------------------------------MSYV
MMAR_4280|M.marinum_M ----------------------------------------------MSYV
Mb1205c|M.bovis_AF2122/97 ----------------------------------------------MSFV
Rv1172c|M.tuberculosis_H37Rv ----------------------------------------------MSFV
MSMEG_0618|M.smegmatis_MC2_155 -----------------------------------------------MTL
Mvan_0414|M.vanbaalenii_PYR-1 -----------------------------------------------MTL
MLBr_01183|M.leprae_Br4923 ---------------------------------------------MPLFL
MAV_1346|M.avium_104 ---------------------------------------------MS-FV
TH_3064|M.thermoresistible__bu -------------------VAAVGAAAVAFAPVQALPPDIAVTAEQPVLD
MAB_2679|M.abscessus_ATCC_1997 MDRTANPLFKAGMAAITATALIVAPAVTPPTRQSIPLPDIRSASVRLSSL
Mflv_2738|M.gilvum_PYR-GCK -------MGNEMHASIRAALAAGVTTLTASALAFAPPPQPPAAQALSVQP
MUL_1019|M.ulcerans_Agy99 ATVPEALTAAASDAAGIGTTISSANAAASAPTT----GVLAAAGDQVSAQ
MMAR_4280|M.marinum_M AAVPEALTAAASDVAGIGTTISSANAAASAPTT----GVLAAAGDQVSAQ
Mb1205c|M.bovis_AF2122/97 FAAPEALAAAAADMAGIGSTLNAANVVAAVPTT----GVLAAAADEVSTQ
Rv1172c|M.tuberculosis_H37Rv FAAPEALAAAAADMAGIGSTLNAANVVAAVPTT----GVLAAAADEVSTQ
MSMEG_0618|M.smegmatis_MC2_155 RVVPEGLTAASSAVEALTARLAAAHAAAAPMIS----TVLPPAADAVSLQ
Mvan_0414|M.vanbaalenii_PYR-1 RVVPEGLTAAGAAVEALTARMAAAHAAAAPVVT----AVLPPAADVVSLQ
MLBr_01183|M.leprae_Br4923 NAEPQALTAAANTLEGLSAATVASNAAAAQLTT----EIAPPAADDVSIL
MAV_1346|M.avium_104 TTRPEALLAVASMLEGLGSSMDAQNAAAAAPTT----SIAPAAADEVSAL
TH_3064|M.thermoresistible__bu ASASREAVALLAAVQGLAVRPASPPVAPTAPTP----DEVQAAVTAIQEL
MAB_2679|M.abscessus_ATCC_1997 AFTPRAAEVPASPLAALKLSLSPASAAPASPLKRAPLGQLATAVQPRAAA
Mflv_2738|M.gilvum_PYR-GCK LSIASEMVSAASFTAGSTRILPVTDPRALAALTAFTQPWPGTPSDAADPT
. . . ..
MUL_1019|M.ulcerans_Agy99 VAALFSSHGEIYQRLSSQLST-FHDQF------AAALNTSANSYASAEAN
MMAR_4280|M.marinum_M VAALFSSHGEIYQRLSSQLST-FHDQF------AAALNTSANSYASAEAN
Mb1205c|M.bovis_AF2122/97 VAALLSAHAQGYQQLSRQMMTAFHDQF------VQALRASADAYATAEAS
Rv1172c|M.tuberculosis_H37Rv VAALLSAHAQGYQQLSRQMMTAFHDQF------VQALRASADAYATAEAS
MSMEG_0618|M.smegmatis_MC2_155 TAAGFSANGAQQSAVAAQGVE-ELGRS------GVGVGESGVSYATGDAQ
Mvan_0414|M.vanbaalenii_PYR-1 AATGFSARAAEHQSVAAQGVE-ELGRS------GIAVGESAASYAGGDAM
MLBr_01183|M.leprae_Br4923 LAHFFSGHGRQYQAHASQGAT-NHQDL------IQSLLTSSSAYAGTETA
MAV_1346|M.avium_104 QAAQFSAYGTWYQQVSAQAKA-IHQTL------VQNLDTNADSYGATEAA
TH_3064|M.thermoresistible__bu AAPGAPATTAAADSAIEVGTAAFPGAANA-IKDVYNLIEPYVAWGVEVAQ
MAB_2679|M.abscessus_ATCC_1997 APLPTPVSAPTQPDAATASSPVVASSLTNGIDQAYQFIQYWVDYGVDLAQ
Mflv_2738|M.gilvum_PYR-GCK DLATVTTADEPLEDPVALNAASDVIDT------VYAFTRYWANYVSLELG
. . :
MUL_1019|M.ulcerans_Agy99 AAKTLLSAVNSPAEKL-----------LGQPLMGQGGIV---ANAVSQVQ
MMAR_4280|M.marinum_M AAKTLLSAVNSPAEKL-----------LGQPLMGQGGIV---ANAVSQVQ
Mb1205c|M.bovis_AF2122/97 AAQTMVNAVNAPARAL-----------LGHPLISADASTGGGSNALSRVH
Rv1172c|M.tuberculosis_H37Rv AAQTMVNAVNAPARAL-----------LGHPLISADASTGGGSNALSRVQ
MSMEG_0618|M.smegmatis_MC2_155 AAASYLTARGL---------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 AASSYLIARG----------------------------------------
MLBr_01183|M.leprae_Br4923 N-----------------------------------------HDSL----
MAV_1346|M.avium_104 NRVNTSAAALQGLAPN-----------VIPNAAPAADPPPAGTTSLGTSI
TH_3064|M.thermoresistible__bu WAVGWVPWVGLLSGQIG--IFYTFGEAIVYSVVFNVADWIGGTVGFGEGL
MAB_2679|M.abscessus_ATCC_1997 WGAGFVPVIGGLVSAQIGIVYDNLVRPIANSFVYNLVDPILNDPSFSNIV
Mflv_2738|M.gilvum_PYR-GCK PWLINWVPFGYLISDQILIWYPNFVLPVVDSFVYDFLDPVVNDPLNLEVW
MUL_1019|M.ulcerans_Agy99 SVFAGAG-SNALG------ANAS-MLALAPTGG--------------AAT
MMAR_4280|M.marinum_M SVFAGAG-SNALG------ANAS-MLALAPTGG--------------AAT
Mb1205c|M.bovis_AF2122/97 SMFLGTGGSSALGGSAAANAAASGALQLQPTGG--------------ASG
Rv1172c|M.tuberculosis_H37Rv SMFLGTGGSSALGGSAAANAAASGALQLQPTGG--------------ASG
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 GWAQNVG------------AAASDFITLGEGQF--------------APV
TH_3064|M.thermoresistible__bu ANIAAATSQAVTDLIRDEINWVRSFFPPLPPLP--------------PVL
MAB_2679|M.abscessus_ATCC_1997 NSFGRFGSDIVNSVINFAWAEARYFLPPLPPLPGLALQTTTDANGAAPTS
Mflv_2738|M.gilvum_PYR-GCK AQGIGSIIDTAVAGVRNGVTAEIQYILDFGWFP----------------F
MUL_1019|M.ulcerans_Agy99 AAASGSLLG-PIASAAAAPAAILPVSVATAIQNFCLAVEPWVQYGFNLAS
MMAR_4280|M.marinum_M AAASGSLLG-PIASAAAAPAAILPVSVATAIQNFYLAVEPWVQYGFNLAS
Mb1205c|M.bovis_AF2122/97 LSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTA
Rv1172c|M.tuberculosis_H37Rv LSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTA
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 PGAAGIPNFNPGLTAATTAGPPAPAAPAAAAG---APVLASMGRGPSIGG
TH_3064|M.thermoresistible__bu PAALPMSLPTSLPTSEAHPAQQVGIAKAGAAAEVAGSPTATTVVEGDLPA
MAB_2679|M.abscessus_ATCC_1997 VHEALVPFTKAFKDAEAHFAEALGLTKPDPKSAALEKTGTAAQTGESLKE
Mflv_2738|M.gilvum_PYR-GCK PLPPLPSFPVPGAAGASAESADADVQLASVDEADAAGAVEDAVEGAEGGA
MUL_1019|M.ulcerans_Agy99 WAVGWVPWIG----------------------------------------
MMAR_4280|M.marinum_M WAVGWVPWIG----------------------------------------
Mb1205c|M.bovis_AF2122/97 WAVGWLPYIG----------------------------------------
Rv1172c|M.tuberculosis_H37Rv WAVGWLPYIG----------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 LSVPPSWAPG----------------------------------------
TH_3064|M.thermoresistible__bu DEAPEPPAQA----------------------------------------
MAB_2679|M.abscessus_ATCC_1997 TTGESVQEEGKTAETGAATGTKEALDRKESAEGKASANDKATAVAEKTKA
Mflv_2738|M.gilvum_PYR-GCK AEAVEVDGDD----------------------------------------
MUL_1019|M.ulcerans_Agy99 -------ILAPQINFFYYLFEPIVQSGLFNTLDWLDGTVTFSQGLSNFSQ
MMAR_4280|M.marinum_M -------ILAPQINFFYYLFEPIVQSGLFNTLDWLDGTITFSQGLS----
Mb1205c|M.bovis_AF2122/97 -------ILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALT----
Rv1172c|M.tuberculosis_H37Rv -------ILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALT----
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 -------GVAPAA---NATPAQLVGAGFTSAAPDTAPVTAVPGGVP----
TH_3064|M.thermoresistible__bu -------QRQPVQRGALLAETDPVEDDSSAPDAGESPAPGVDVRPGPRPG
MAB_2679|M.abscessus_ATCC_1997 GDKATTESREPVTTATEAAKESTKDSVKDAAVPGVAADSDAASGNLTKGT
Mflv_2738|M.gilvum_PYR-GCK -----IVAQKPADVSGEAVDEALVEEESVEEESVDVVDEESVEAVD----
MUL_1019|M.ulcerans_Agy99 GLSNFWSATTASVNQFIQTEIN----WIRNFFPPFPPLP---F-------
MMAR_4280|M.marinum_M ---NFWSATTASVNQFIQTEIN----WIRHFFPPFPPLP---F-------
Mb1205c|M.bovis_AF2122/97 ---NIETATAASINQFINTEIN----WIRGFLPPLPPISPPGFPSLP---
Rv1172c|M.tuberculosis_H37Rv ---NIETATAASINQFINTEIN----WIRGFLPPLPPISPPGFPSLP---
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 -----SMATAGRGGYGLGAPRY----GVKPTVMPKPAI------------
TH_3064|M.thermoresistible__bu TALRDSLQEVARAATASVEXXXXGPPWPAGPAMPAPTGPPCSSPAGSAPP
MAB_2679|M.abscessus_ATCC_1997 LAAKETGNQQQSATDGKPSPSSAPADKPDKPVKPKVPAASTTEHGSISAQ
Mflv_2738|M.gilvum_PYR-GCK ---DETDQVEETVDEESAEDGATTDDEPTDEDAPAGSDSGDDTSGSETE-
MUL_1019|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4280|M.marinum_M --------------------------------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3064|M.thermoresistible__bu APCAAFITCSISELNIPVCPPSPPAP------------------------
MAB_2679|M.abscessus_ATCC_1997 GIVRGPVSQSTSGQSGPSASTPKTADSKVSSSGASGFQTSDTGTPESKMS
Mflv_2738|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1019|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4280|M.marinum_M --------------------------------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_3064|M.thermoresistible__bu --------------------------------------------------
MAB_2679|M.abscessus_ATCC_1997 DTKTATGTTAGTKATETKPKAAETKPSDAKSSGSTTSGTKSPGTTAHDSA
Mflv_2738|M.gilvum_PYR-GCK --------------------------------------------------
MUL_1019|M.ulcerans_Agy99 --------------------------
MMAR_4280|M.marinum_M --------------------------
Mb1205c|M.bovis_AF2122/97 --------------------------
Rv1172c|M.tuberculosis_H37Rv --------------------------
MSMEG_0618|M.smegmatis_MC2_155 --------------------------
Mvan_0414|M.vanbaalenii_PYR-1 --------------------------
MLBr_01183|M.leprae_Br4923 --------------------------
MAV_1346|M.avium_104 --------------------------
TH_3064|M.thermoresistible__bu --------------------------
MAB_2679|M.abscessus_ATCC_1997 NKPSASASSAAKSGGEGSKSSSGSHR
Mflv_2738|M.gilvum_PYR-GCK --------------------------