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SFVIAAPEVMAAAATDLANIGSSISAASAAAAGPTMGILAAGADEVSVAISALFGSHAQGYQTLSAQLAA YHNQFVRALNAGAGSYASAEAANVQQTLLNAINAPTQTLLGRPLIGNGADGGPGQNGGPGGLLYGNGGNG GAGDTANPNGGNGGSAGLIGNGGAGGAGAATGAGGAGGNGGWLYGNGGPGGAAGLGTAGGVSPAGGAGGA AGLWGHGGAGGAGGSASGAPGAGGAGGDGGRGGLLYGDGGAGGAGGNGSNGVTGVHGGNGGAGGAAGLIG NGGAGGDGGNGGLSNTGASGGAGGAGGAALIGNGGDGGHGGNGGHGNSGGAGGAGGAGGAGGAGGHVGLI GNGGNGGAGGNGGNDNSSTLADAGSGGAGAAGGNGGLFYGNGGVGGRGGNGGFSSAGTSGGDGGIGGAGG IGGLIGSGGGGGDGGNGGQAPTPGNAGDGGAGGNARLIGDGGRGGNGGEGGDGPPGVKGDGGNGGNGGNA VVIGNGGNGGAGGFGIPVGSGGAGGSRGVLFGTPGANGADG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2162c | PE_PGRS38 | - | 100% (532) | PE-PGRS FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | e-171 | 55.92% (608) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv1396c | PE_PGRS25 | e-170 | 57.58% (587) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2186c | PE_PGRS38 | 0.0 | 86.09% (532) | hypothetical protein Mb2186c |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-101 | 45.16% (527) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01183 | - | 1e-10 | 33.70% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 2e-48 | 34.53% (417) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_4223 | - | 1e-174 | 54.58% (601) | PE-PGRS family protein |
| M. avium 104 | MAV_4827 | - | 5e-25 | 41.07% (168) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 2e-86 | 37.82% (624) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 8e-44 | 39.93% (303) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_3292 | - | 1e-163 | 53.32% (617) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-102 | 45.15% (536) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2162c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2186c|M.bovis_AF2122/97 --------------------------------------------------
MUL_3292|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MMAR_4223|M.marinum_M --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv2162c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2186c|M.bovis_AF2122/97 --------------------------------------------------
MUL_3292|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MMAR_4223|M.marinum_M --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Rv2162c|M.tuberculosis_H37Rv ---------------------------------------MSFVIAAP---
Mb2186c|M.bovis_AF2122/97 ---------------------------------------MSFVIAAP---
MUL_3292|M.ulcerans_Agy99 ---------------------------------------MSYVIAAP---
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MMAR_4223|M.marinum_M ---------------------------------------MSYLVAVP---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP
MAV_4827|M.avium_104 --------------------------------------------------
Rv2162c|M.tuberculosis_H37Rv ----------------------------------------EVMAAAATDL
Mb2186c|M.bovis_AF2122/97 ----------------------------------------EVMAAAATDL
MUL_3292|M.ulcerans_Agy99 ----------------------------------------EMLAGAATDL
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MMAR_4223|M.marinum_M ----------------------------------------EMLASAALDL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------VEAASYVADPEAAL
MAV_4827|M.avium_104 ---------------------------------------MNIVLGVSMAP
Rv2162c|M.tuberculosis_H37Rv AN---------------------------------------IGSSISAAS
Mb2186c|M.bovis_AF2122/97 AN---------------------------------------IGSSISAAS
MUL_3292|M.ulcerans_Agy99 AG---------------------------------------IGAALQSAN
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MMAR_4223|M.marinum_M DN---------------------------------------IGSTITAAN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AN-----------------------------------------AGLSAVS
MAV_4827|M.avium_104 SS--------------------------------------IQMVVLEGEY
Rv2162c|M.tuberculosis_H37Rv AA-----------AAGPTMGILAAGADEVSVAISALFGS---------HA
Mb2186c|M.bovis_AF2122/97 AA-----------AAGPTMGILAAGADEVSVAISALFGS---------HA
MUL_3292|M.ulcerans_Agy99 GA-----------AAAPITGVLAAGADEISAAVAALFSG---------HA
TH_3810|M.thermoresistible__bu -----------------------VDGDGGSGGRTGLFSKLSRGGDGGDGG
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGG--NGGNGGNGL
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGG--NGGNGGNGL
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG---NGGNGGVGW
MMAR_4223|M.marinum_M AA-----------AAAPTTAVLAAGADEISAAVAALFTG---------HA
MLBr_01183|M.leprae_Br4923 ------------------MPLFLNAEPQALTAAANTLEG---------LS
MAB_4284c|M.abscessus_ATCC_199 AA-----------QVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNL
MAV_4827|M.avium_104 AD-------------GATVEEDAIDVTGADDAATASAPDR-----VISAI
Rv2162c|M.tuberculosis_H37Rv QGYQTLSAQLAAYHNQFVRALNAGAGSYASAEAAN--------------V
Mb2186c|M.bovis_AF2122/97 QGYQTLSAQLAAYHNQFVRALNAGAGSYASAEAAN--------------V
MUL_3292|M.ulcerans_Agy99 LDYQALSTQMAGFHQQFVTALNSAGASYAAAEAASANP--------LQAV
TH_3810|M.thermoresistible__bu LGGNGGHGGGTGIISLLSLAGNGGNGGNGYR----------------TTD
Mflv_5091|M.gilvum_PYR-GCK GGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA
Mvan_1264|M.vanbaalenii_PYR-1 GSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA
MSMEG_0868|M.smegmatis_MC2_155 AGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG
MMAR_4223|M.marinum_M QAYQWLGAQAGAFHSQFIQALTGSGIAYAGAEAANASP--------LQTA
MLBr_01183|M.leprae_Br4923 AATVASNAAAAQLTTEIAPPAADD-------------------------V
MAB_4284c|M.abscessus_ATCC_199 QNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHN---------PIA
MAV_4827|M.avium_104 LGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARR---------IDN
Rv2162c|M.tuberculosis_H37Rv QQTLLNAINAPTQTLLGRPLIGNGADGGPGQNGGPGG-------------
Mb2186c|M.bovis_AF2122/97 QQTLLNAINAPTQTLLGRPLIGNGADGGPGQNGGPGG-------------
MUL_3292|M.ulcerans_Agy99 EQQLLGVINAPTQALLGRPLIGDGTAGAPGQNGGDGG-------------
TH_3810|M.thermoresistible__bu NNALDGGHGGNGGNVGFFSLFNLGGAGGWGGSGVDG--------------
Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------------
Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------------
MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN
MMAR_4223|M.marinum_M AQELLAVINTPTQTLLGRPLIGNGADGAPGQAGGDGG-------------
MLBr_01183|M.leprae_Br4923 SILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSS-------------
MAB_4284c|M.abscessus_ATCC_199 SGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIG-----------
MAV_4827|M.avium_104 VMLVSAFLAAAALAQNVGGAMGYERTAVLLVEPDTAT-------------
.
Rv2162c|M.tuberculosis_H37Rv ---LLYGNGGNGGAG------DTANP------------------------
Mb2186c|M.bovis_AF2122/97 ---LLYGNGGNGGAG------DTANP------------------------
MUL_3292|M.ulcerans_Agy99 ---LLWGNGGAGGVG------TAAHP------------------------
TH_3810|M.thermoresistible__bu --VDVVGGNPDGGTPGAHG--ESHTPGVYTDR------------------
Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD
MMAR_4223|M.marinum_M ---LLYGNGGNGGTS------TTAG-------------------------
MLBr_01183|M.leprae_Br4923 -----SAYAGTETAN------HDSL-------------------------
MAB_4284c|M.abscessus_ATCC_199 --DGAVAVGGSNSGPIASGQGSTAVNGDVRDSN-----------------
MAV_4827|M.avium_104 ---LAVVETSDGSIPDVYKQQIRAES------------------------
Rv2162c|M.tuberculosis_H37Rv --------------------------------------------NGGNGG
Mb2186c|M.bovis_AF2122/97 --------------------------------------------NGGNGG
MUL_3292|M.ulcerans_Agy99 --------------------------------------------TGGSGG
TH_3810|M.thermoresistible__bu --------------------------------------------QGEDGE
Mflv_5091|M.gilvum_PYR-GCK --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG
Mvan_1264|M.vanbaalenii_PYR-1 --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG
MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
MMAR_4223|M.marinum_M -------------------------------------------VAGGDGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------IINADHG
MAV_4827|M.avium_104 --------------------------------------------YGDAAG
Rv2162c|M.tuberculosis_H37Rv SAGLIGNGGAGGAG-------------------------AATG-------
Mb2186c|M.bovis_AF2122/97 SAGLIGNGGAGGAG-------------------------AATG-------
MUL_3292|M.ulcerans_Agy99 SAGLIGTGGAGGAGY------------------GPAAQTGATGGSGGVGG
TH_3810|M.thermoresistible__bu DGTGTGIGGRGGNG------------------------------------
Mflv_5091|M.gilvum_PYR-GCK AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG
Mvan_1264|M.vanbaalenii_PYR-1 AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG
MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
MMAR_4223|M.marinum_M AAGLIGNGGAGGGG------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SNVGVDQSQTRVGG--------------------DYTNVSGHGSADIDKS
MAV_4827|M.avium_104 QLSAMVAGLEKLESLP-----------------GGLLLVGSGVDVAPLKQ
Rv2162c|M.tuberculosis_H37Rv --------------------AGGAGGNGG---------------------
Mb2186c|M.bovis_AF2122/97 --------------------AGGAGGNGG---------------------
MUL_3292|M.ulcerans_Agy99 T-------GGSGLDGPDSGAAGGAGGSGGSGGAA----------------
TH_3810|M.thermoresistible__bu ------------------GSSSGTHPMAEDG-------------------
Mflv_5091|M.gilvum_PYR-GCK Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1 Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
MMAR_4223|M.marinum_M ----------------GAGALGGNGGAGG---------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VTVVDDHSQRNTTNINDSFNTDRSTNIGSGNTTN----------------
MAV_4827|M.avium_104 VLQTTTFLDVSVAEEPETALARGAALAAANAP------------------
Rv2162c|M.tuberculosis_H37Rv -WLYGNGGPGGAAGLGTAGGV-------------------------SPAG
Mb2186c|M.bovis_AF2122/97 -WLYGNGGPGGAAGLGTAGGV-------------------------SPAG
MUL_3292|M.ulcerans_Agy99 -RLFGNGGAGGSGGKGGNGGS-------------------------AIET
TH_3810|M.thermoresistible__bu -----EHVKALDGRPGLDGG----------------------------NG
Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
MMAR_4223|M.marinum_M -WLFGQGGAGGNGGTATLAGG------------------------AGGAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -TEIGSHNQANIGTSTSAGGS-------------------------AAVG
MAV_4827|M.avium_104 --LFASSTAALAYAQDPGTGAVDQYSLP-----------------DYLYV
Rv2162c|M.tuberculosis_H37Rv GAGGAAGLWGHG--------------------------------------
Mb2186c|M.bovis_AF2122/97 GAGGAAGLWGHG--------------------------------------
MUL_3292|M.ulcerans_Agy99 GNDGAAGAGGHGGWLV----------------------------------
TH_3810|M.thermoresistible__bu SHGGNGGHGGRG----GFLG------------------------------
Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRG----GLFG---------------KGGNAGNGAD-----
Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRG----SLFG---------------RGGNAGNGGN-----
MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIA----AIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQA
MMAR_4223|M.marinum_M GVGGSAGLWGTG--------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAG-------------------------------------
MAV_4827|M.avium_104 PVDPEPGDDELAYS------------------------------------
Rv2162c|M.tuberculosis_H37Rv ------------------GAGGAGGS--------ASGAPGAG--------
Mb2186c|M.bovis_AF2122/97 ------------------GAGGAGGS--------ASGAPGAG--------
MUL_3292|M.ulcerans_Agy99 ---------------GNGGIGGDGGSGGVGGDAGAYGPPANG--------
TH_3810|M.thermoresistible__bu ----------------IGGSGGWGGHGGNGGDTDADGGNGG---------
Mflv_5091|M.gilvum_PYR-GCK -----------------GGTGGAGGAGGTGG-TGGAGGTGG---------
Mvan_1264|M.vanbaalenii_PYR-1 -----------------GGTGGNGGNGGTGG-TGGNGGTGG---------
MSMEG_0868|M.smegmatis_MC2_155 YDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANG
MMAR_4223|M.marinum_M ------------------GAGGNGGFGALN--LAGDGGAGAG--------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ----------------NAGLAGNAGLAGNAGLAGNAGLAGN---------
MAV_4827|M.avium_104 ---------------AVGEEDAESPTVVIEKLFLPEDSEPRR--------
Rv2162c|M.tuberculosis_H37Rv ----------------------GAGGDGGRG------GLLYGDGGAGGAG
Mb2186c|M.bovis_AF2122/97 ----------------------GAGGDGGRG------GLLYGDGGAGGAG
MUL_3292|M.ulcerans_Agy99 ----------------------GAGGHGGMGGVGGDAGLLFGSGGAGGVG
TH_3810|M.thermoresistible__bu ---------------------------------------------DGGNG
Mflv_5091|M.gilvum_PYR-GCK --------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 --------TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTG
MSMEG_0868|M.smegmatis_MC2_155 QHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHG
MMAR_4223|M.marinum_M ------------------------GGDGGRG------GWLYGNGGVGGTG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------------------AGLAGNAGLAGNAGLAGNAGLAGNAG
MAV_4827|M.avium_104 --------------------RPVLLVGSGLAVVGISAVLALEIALAIGIR
Rv2162c|M.tuberculosis_H37Rv GNGSNGVTGVHGGNGGAG----GAAG------LIGNG------------G
Mb2186c|M.bovis_AF2122/97 GNGSNGVTGVHGGNGGAG----GAAG------LIGNG------------G
MUL_3292|M.ulcerans_Agy99 GNGAIGGTGVMSGAGGAG----GDGGNGGYAQLIGDG------------G
TH_3810|M.thermoresistible__bu GSAGRGGTGGLRGVFGIN--------------------------------
Mflv_5091|M.gilvum_PYR-GCK GTGGKGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGKGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGG
MSMEG_0868|M.smegmatis_MC2_155 GDGGRGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGG
MMAR_4223|M.marinum_M GTGGIGLQGASGGDGGAG----GGTGLWGTGGVGGNG------------G
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAG--LAGNAGLAGNAGLAGNAG-----------L
MAV_4827|M.avium_104 TTGTVALQPTPNQHLIVP-----TEQAPAPPPVQASAP------------
Rv2162c|M.tuberculosis_H37Rv AGGDGGNG--------------GLSN-----------TGASGGAGG----
Mb2186c|M.bovis_AF2122/97 AGGDGGNG--------------GLSN-----------TGASGGAGG----
MUL_3292|M.ulcerans_Agy99 GGGAGGAG--------------YSASGLPP-----AGIGAPGGAGG----
TH_3810|M.thermoresistible__bu -GGNGRAG-----------------------------LGGRGXXXX----
Mflv_5091|M.gilvum_PYR-GCK TGGTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG----
Mvan_1264|M.vanbaalenii_PYR-1 TGGTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG----
MSMEG_0868|M.smegmatis_MC2_155 NGGNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALI
MMAR_4223|M.marinum_M TGGIGLDG------------VAGHIGG---------GNAGNAGNGG----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAG--------------------------NAGLAGNAGLAG----
MAV_4827|M.avium_104 QPKISVPEP----------------------------VAAPKPLSP----
Rv2162c|M.tuberculosis_H37Rv -------------AGGAA--------------------------------
Mb2186c|M.bovis_AF2122/97 -------------AGGAA--------------------------------
MUL_3292|M.ulcerans_Agy99 -------------AGGSGG-------------------------------
TH_3810|M.thermoresistible__bu -------------GGGVG--------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------TGGTGGQGG-LGGGGGTG-------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------TGGTGGQGG-LGGVGGTG-------------------
MSMEG_0868|M.smegmatis_MC2_155 RATVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASG
MMAR_4223|M.marinum_M -------------TGGSGG-------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -------------NAGLAGN------------------------------
MAV_4827|M.avium_104 ------------PVAAPLP-------------------------------
Rv2162c|M.tuberculosis_H37Rv -------------------------------------LIGNGGDGGHGGN
Mb2186c|M.bovis_AF2122/97 -------------------------------------LIGNGGDGGHGGN
MUL_3292|M.ulcerans_Agy99 ------------------------------------WLVGNGGAGGIGGI
TH_3810|M.thermoresistible__bu -------------------------------------AAVRSGNGVFSGG
Mflv_5091|M.gilvum_PYR-GCK ----GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGL
Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGL
MSMEG_0868|M.smegmatis_MC2_155 TATDGHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGL
MMAR_4223|M.marinum_M ------------------------------------LLLGNGGDGGHGGT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------------------------AAVAGNAAVAGNAAV
MAV_4827|M.avium_104 -------------------------------------AAPPPAAPPLPEA
Rv2162c|M.tuberculosis_H37Rv GGHGNSGGAGGAGGAGGAGGAGGHVG------LIGNGGNGGAGGNGGNDN
Mb2186c|M.bovis_AF2122/97 GGHGNSGGAG------GAGGAGGHVG------LIGNGGNGGAGGNGGNDN
MUL_3292|M.ulcerans_Agy99 GASGSFGAPSGQG---GNGGIGGAAG------LFGQGGAGGNGGQGGGDD
TH_3810|M.thermoresistible__bu GGTPSAGFGVPTTIQFPAGSCTSRAV------SREGIMPSSRAAS-----
Mflv_5091|M.gilvum_PYR-GCK GGFGGSGGTGGQGGLGGPGGSTGGAG------GAGG--QAGTAGKGGLFG
Mvan_1264|M.vanbaalenii_PYR-1 GGFGGVGGTGGQGGQGGPGGSTGGAG------GAGG--QAGVAGKGGLFG
MSMEG_0868|M.smegmatis_MC2_155 GGNGGDGVVNTTANAANPGSATGTAT------GGDGGKATGTASQGGNGG
MMAR_4223|M.marinum_M GGGGGRGINGADGGHGGDGGTGGAAGSAGLLFGDGGTGGHGGAGFGGGNG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVGGSTAVGGGAHT
MAV_4827|M.avium_104 PPIPAAPPVVPVPVVVPPVPVPVPVR------IPVPDPVSPPQLLAPPRL
Rv2162c|M.tuberculosis_H37Rv S-----STLADAGSGGAGAAGGNGGLFYGNGGVGGRG-------------
Mb2186c|M.bovis_AF2122/97 S-----STLADAGSGGAGAAGGNGGLFYGNGGVGGRG-------------
MUL_3292|M.ulcerans_Agy99 -------FALSGGAGGAGGAGGHGGQLYGDGGGGGAG-------------
TH_3810|M.thermoresistible__bu ---------ARAGAACASSTSRSRRSFCCSRA------------------
Mflv_5091|M.gilvum_PYR-GCK ----GSGSAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-
Mvan_1264|M.vanbaalenii_PYR-1 ----GSGSAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-
MSMEG_0868|M.smegmatis_MC2_155 PSWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGV
MMAR_4223|M.marinum_M SDSPQGGQGGNAGVAGNGGAGGSAAMLFGNGGAGGNGGSGGDGGHGGNST
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GVGGGVSTGVGVGSHVGGGISESLGGSGSVGGSTAVG-------GGAHTG
MAV_4827|M.avium_104 SVPQPVQPPVRVPQPPSPPQVGGTVPQSPPQHQTPPG-------EGTPPK
Rv2162c|M.tuberculosis_H37Rv GNGGFSSAGTSGGDGGIGGAGGIG---------------GLIGSGGGGGD
Mb2186c|M.bovis_AF2122/97 GNG-----------------------------------------------
MUL_3292|M.ulcerans_Agy99 GMGGSVDIAESGVTGGRGGSGSVG---------------GGAGLWGAGGQ
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATGAAGKAGATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-N
Mvan_1264|M.vanbaalenii_PYR-1 ATGASGAQGSAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-N
MSMEG_0868|M.smegmatis_MC2_155 ATGNTATGGDGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGN
MMAR_4223|M.marinum_M VSVPGGIGGDAGAGGTGGSAGKSG----------LLFGAGGAGGQGGGGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 VGGGVSTGVGVGSHVGGGISESLG-------------GSGSVGGSTAVGG
MAV_4827|M.avium_104 PDGPGNYGGGHVPTPGAGGSGGSG------------GGHVPTPGAGGSGG
Rv2162c|M.tuberculosis_H37Rv GGN--------GGQAPTPGNAG--------DGGAGG----NARLIGDGGR
Mb2186c|M.bovis_AF2122/97 ------------GQAPTPGNAG--------DGGAGG----NARLIGDGGR
MUL_3292|M.ulcerans_Agy99 GGDGAQGGDGGAGVDTTTGAGG--------DGGAGAGGGTSGFLYGNGGA
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GANGSQGAAGKAGATGTTGATG--------AAGEDGDAGSGGSG-INGGA
Mvan_1264|M.vanbaalenii_PYR-1 GANGSQGAAGKAGATGTTGATG--------AAGDAGDPGSEAVD-INGGA
MSMEG_0868|M.smegmatis_MC2_155 GGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGD
MMAR_4223|M.marinum_M TGGDGGNNIIGANVGGDGGAGG--------AGGLGGNGTDGGWLSGNGGD
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GAHTGVGGGVNTGVGVGSHVGG------GISESLGGSGSVGGSTAVGGGA
MAV_4827|M.avium_104 SGGGHVPTPGTGGPGGTGGSGGG----HVPTPGAGTPGGSGGGHLPFPGA
Rv2162c|M.tuberculosis_H37Rv GGNGG---------EGGDGPPGVKGDGGNGGNGGN-----AVVIGNGGNG
Mb2186c|M.bovis_AF2122/97 GGNGG---------EGGDGPPGVKGDGGNGGNGGN-----AVVIGNGGNG
MUL_3292|M.ulcerans_Agy99 GGAGG---------HGGGGP-GMGGDGGDGGDGGR-----AQLIGTGGNG
TH_3810|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGAGG-----------AGGEGGEGGDGGKGGAGAE--------GGAGGGG
Mvan_1264|M.vanbaalenii_PYR-1 GGAGG-----------AGGEGGEGGAGGAGGDGSE--------GGAGGSG
MSMEG_0868|M.smegmatis_MC2_155 GGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNG
MMAR_4223|M.marinum_M GGAGGQ----GGDGGHGGSPGGFDGKSGVGGDGGD-----GGNARIIGNG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 HTSAIN--------DALGGSGSVGGSTAVGGGAHTSAINESMNSSINASH
MAV_4827|M.avium_104 GSTPGG---------SGGGHLPTPGAGTPGGGLGGFGGGHAPAPGGGLGG
Rv2162c|M.tuberculosis_H37Rv GAGGFGIP---VGSGGAGGSRGVLFGTPGANGADG-----------
Mb2186c|M.bovis_AF2122/97 GAGGFGIP---VGSGGAGGSRGVLFGTPGANGADG-----------
MUL_3292|M.ulcerans_Agy99 GAGGTAAPGGTDGTAGAAGKGGVLFGTDGATG--------------
TH_3810|M.thermoresistible__bu ----------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD-------
Mvan_1264|M.vanbaalenii_PYR-1 GAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD--------
MSMEG_0868|M.smegmatis_MC2_155 GTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP-------
MMAR_4223|M.marinum_M GNGGNGGAGSTDGEGGQGGAAGLLFGQPGSMGT-------------
MLBr_01183|M.leprae_Br4923 ----------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH
MAV_4827|M.avium_104 GGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK--------------