For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
DFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRA WIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYW SQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLYELIGSVSETVGSFAAPATKNLPSKLWTLLTK GTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGG LSVPPSWVADKSITPLAKAVPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1168c | PPE17 | - | 100% (346) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1808 | PPE32 | 4e-47 | 35.20% (392) | PPE family protein |
| M. tuberculosis H37Rv | Rv1802 | PPE30 | 1e-46 | 35.73% (389) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1201c | PPE17a | 3e-93 | 97.13% (174) | hypothetical protein Mb1201c |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-19 | 34.34% (166) | PPE protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-29 | 28.43% (415) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 2e-20 | 28.09% (324) | PPE-family protein |
| M. marinum M | MMAR_2684 | - | 4e-46 | 34.89% (407) | PPE family protein, PPE32 |
| M. avium 104 | MAV_3356 | - | 1e-44 | 35.84% (399) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-19 | 32.65% (196) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-20 | 27.93% (358) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 2e-46 | 34.89% (407) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-19 | 32.47% (194) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
Rv1168c|M.tuberculosis_H37Rv -------------MDFTIFPPEFNS--LNIQGSARPFLVAANAWKNLSNE
Mb1201c|M.bovis_AF2122/97 -------------MDFTIFPPEFNS--LNIQGSARPFLVAANAWKNLSNE
MMAR_2684|M.marinum_M ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_3356|M.avium_104 -------------MDFGSLPPEINSGRIYSGPGSAPLLAAAAAWHGLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :* : .. .. .*. * :. :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
Rv1168c|M.tuberculosis_H37Rv LSYAASRFESEINGLITS-WRGPSSTIMAAAVAPFRAWIVTTASLAELVA
Mb1201c|M.bovis_AF2122/97 LSYAASRFESEINGLITS-WRGPSSTIMAAAVAPFRAWIVTTASLAELVA
MMAR_2684|M.marinum_M LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_3356|M.avium_104 MHSAAASYGSAIAELRTL-WHGPSSTAMAAAAAPFIAWLDGTAVQAEQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
* : : * .: . *: *: . . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
Rv1168c|M.tuberculosis_H37Rv DHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALD
Mb1201c|M.bovis_AF2122/97 DHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALD
MMAR_2684|M.marinum_M TQAKLAAGAYETAFAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_3356|M.avium_104 AQATAAAAAYDSVFAATVPPPVIAANRALLASLIATNVLGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
: .* *: :. : . : *: * :*.:* :: .* :
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
Rv1168c|M.tuberculosis_H37Rv ALYAQYWSQDGEAMNLYAT-MAAAAARLTPFSPPAPIANPGALARLYELI
Mb1201c|M.bovis_AF2122/97 ALYAQYWSQDGEAMNLYAT-MAAAAARLTPFSPPGADRQP----------
MMAR_2684|M.marinum_M AQYLEMWAQDAAAMYAYAG-TAAAASALTPFTEPPQTTNPVAGAAQSAAV
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAG-TAAAASALTPFTEPPQTTNPVAGAAQSAAV
MAV_3356|M.avium_104 AHYAEMWAQDAAAMYAYAG-ASAVATRLTPFGAPPQTADANAAADQSAAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
* * . * * . :* * .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Rv1168c|M.tuberculosis_H37Rv GSVSETVGS-----------------------------------------
Mb1201c|M.bovis_AF2122/97 GRAGQTL-------------------------------------------
MMAR_2684|M.marinum_M AQASSTAASSDVVSQ-----------------------------------
MUL_3072|M.ulcerans_Agy99 AQASSTAASSDVVSQ-----------------------------------
MAV_3356|M.avium_104 ASALQSSTASSVESA-----------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQA-----------------------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Rv1168c|M.tuberculosis_H37Rv --------------------------------------------------
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2684|M.marinum_M --------------------------------------------------
MUL_3072|M.ulcerans_Agy99 --------------------------------------------------
MAV_3356|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Rv1168c|M.tuberculosis_H37Rv ----------------------FAAPATK----NLP------------SK
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2684|M.marinum_M ---LAGLITSVPNALQTLATTSAAPTAAS----ILPEVSLPPWLATNLAN
MUL_3072|M.ulcerans_Agy99 ---LAGLITSVPNALQTLATTSAAPTAAS----ILPEVSLPPWLATNLAN
MAV_3356|M.avium_104 ---LSQAVSQVPVAAQVNAT---AVTAAA----QLP-LSLTDITG-ILKT
MLBr_01182|M.leprae_Br4923 ---ISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQ
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA-
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGAGSPPPAGHSVP
Rv1168c|M.tuberculosis_H37Rv LWTLLTKGTYPL--TAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTP
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2684|M.marinum_M WNTIMATLTGPF--SLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYSPK
MUL_3072|M.ulcerans_Agy99 WNTIMATLTGPF--SLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYSPK
MAV_3356|M.avium_104 FNSVMGTISGPY--TPLGVANLAKNWYQIALSIPSVGTGIQGIGPLLHPK
MLBr_01182|M.leprae_Br4923 LWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTKA
Mflv_0325|M.gilvum_PYR-GCK FVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 FVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 FVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_0669|M.abscessus_ATCC_1997 -ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRL
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
Rv1168c|M.tuberculosis_H37Rv TLKGPLELLPN-------------AVRPAVSATLGNADTIGGLSVPPSWV
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2684|M.marinum_M AITGTLAPLVP-EISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWT
MUL_3072|M.ulcerans_Agy99 AITGTLAPLVP-EISPGGVGLTSASVSNSVSGTMGRAALVGSMSVPQGWT
MAV_3356|M.avium_104 ALTGVLAPLLRSDLLTGSTALSSAGT---VSASAGRAGLVGALSVPANWA
MLBr_01182|M.leprae_Br4923 AES--AFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWT
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTG
MAB_0669|M.abscessus_ATCC_1997 RGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAG
Rv1168c|M.tuberculosis_H37Rv ADKSITPLAKAVP------TSAPGGPSGTS--WAQLGLASLAGGAVGAVA
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2684|M.marinum_M QAAPAMRLVSSVL-STNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGAST
MUL_3072|M.ulcerans_Agy99 QAAPAMRLVSSVL-STNLAAAPTAGLPGEAGVFGQMALSSLAGRAMGAST
MAV_3356|M.avium_104 SAVPAVRTVAAELPETMLDAAPAMAVNGQQGMFGPTALSSLAGRAVGGTA
MLBr_01182|M.leprae_Br4923 TASQPVTAATRALSPARVAVATESESAPLLG-----GGLPMAPMVPGGGS
Mflv_0325|M.gilvum_PYR-GCK TVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_0669|M.abscessus_ATCC_1997 TAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-------------
TH_3113|M.thermoresistible__bu RISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------
Rv1168c|M.tuberculosis_H37Rv ARTRSGVILRSPAAG-----------------------------------
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_2684|M.marinum_M FGSSSGGAVANSLGGVVAEADPAAATIIVIPALDE---------------
MUL_3072|M.ulcerans_Agy99 FGSSSGGAVANSLGGVVAEADPAAATIIVIPALDE---------------
MAV_3356|M.avium_104 TRAVAGSTVR-VPGAVAVDDLATTSTVIVIPPNAK---------------
MLBr_01182|M.leprae_Br4923 GTGGVNTALRLQPRAFVMPRNPAAG-------------------------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ----GGDQN
TH_3113|M.thermoresistible__bu ---------
Rv1168c|M.tuberculosis_H37Rv ---------
Mb1201c|M.bovis_AF2122/97 ---------
MMAR_2684|M.marinum_M ---------
MUL_3072|M.ulcerans_Agy99 ---------
MAV_3356|M.avium_104 ---------
MLBr_01182|M.leprae_Br4923 ---------