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MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFR AWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQY WSQDGEAMNLYATMAAAAARLTPFSPPGADRQPGRAGQTL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1201c | PPE17a | - | 100% (180) | hypothetical protein Mb1201c |
| M. bovis AF2122 / 97 | Mb1837 | PPE32 | 2e-37 | 48.30% (176) | PPE family protein |
| M. bovis AF2122 / 97 | Mb0394c | PPE9 | 2e-36 | 47.67% (172) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-18 | 33.54% (164) | PPE protein |
| M. tuberculosis H37Rv | Rv1168c | PPE17 | 1e-93 | 97.13% (174) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-24 | 35.50% (169) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 1e-17 | 31.98% (172) | PPE-family protein |
| M. marinum M | MMAR_1461 | - | 8e-37 | 46.37% (179) | PPE family protein |
| M. avium 104 | MAV_2906 | - | 3e-36 | 50.00% (170) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-17 | 32.32% (164) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-18 | 33.13% (166) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3072 | - | 1e-36 | 47.16% (176) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-17 | 32.32% (164) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1201c|M.bovis_AF2122/97 -------------MDFTIFPPEFNS--LNIQGSARPFLVAANAWKNLSNE
Rv1168c|M.tuberculosis_H37Rv -------------MDFTIFPPEFNS--LNIQGSARPFLVAANAWKNLSNE
MMAR_1461|M.marinum_M -------------MDFGALPPEINSGRMYVGPGSGPMLAAAVVWDELAAE
MUL_3072|M.ulcerans_Agy99 ------------MIDFGALPPEINSGRMYVGPGAAPLIAAAAAWDELAAE
MAV_2906|M.avium_104 -------------MDFGALPPEVNSGRMYGGAGSGPLLAAAAAWDALGAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** :* : .. .. .*. * :. :
Mb1201c|M.bovis_AF2122/97 LSYAASRFESEINGLIT-SWRGPSSTIMAAAVAPFRAWIVTTASLAELVA
Rv1168c|M.tuberculosis_H37Rv LSYAASRFESEINGLIT-SWRGPSSTIMAAAVAPFRAWIVTTASLAELVA
MMAR_1461|M.marinum_M LYATAAGYRSTLDGLTGGSWRGPASASMAAAAAPYVAWMTATAAQAELAG
MUL_3072|M.ulcerans_Agy99 LQSMAASYGSTVQGLTVAPWTGASSITMAAAAAPYVTWINTTGVQAEQAA
MAV_2906|M.avium_104 LYSFAAAYTSTIAGLTVGSWLGPAATSMSAAAAPFIAWATTTAGQAEQVA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
* : .: * .: *: * . . .
Mb1201c|M.bovis_AF2122/97 DHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALD
Rv1168c|M.tuberculosis_H37Rv DHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALD
MMAR_1461|M.marinum_M SQAKVAASAYETAFAATVPPPVIAANRALLMGLVFTNIFGQNTPAIAATE
MUL_3072|M.ulcerans_Agy99 TQAKLAAGAYETASAATVPPPVIAANRALLMALIATNIFGQNTPAIAAAE
MAV_2906|M.avium_104 TQARLAAAAYETAFAATVPPPVIAANRSLLMTLIATNILGQNTAAIAAAE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
: .* *: :* : . : *: * :*::* :: .* :
Mb1201c|M.bovis_AF2122/97 ALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPGADRQP-----------
Rv1168c|M.tuberculosis_H37Rv ALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGA---------
MMAR_1461|M.marinum_M AHYAEMWAQDAAAMYAYAGSSATATQVTPFTEPPQITSPSGAVSQAAAVT
MUL_3072|M.ulcerans_Agy99 AQYLEMWAQDAAAMYAYAGTAAAASALTPFTEPPQTTNPVAGAAQSAAVA
MAV_2906|M.avium_104 AEYAEMWAQDAAAMYAYAAASAAAAELTPFTEPPRTTESSAAARQSAAVA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPG-GEARSDQS
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
* * . * * . :* *
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
Rv1168c|M.tuberculosis_H37Rv -----------LARL-----------------------------------
MMAR_1461|M.marinum_M EAATASASSDITAQL-----------------------------------
MUL_3072|M.ulcerans_Agy99 QASSTAASSDVVSQL-----------------------------------
MAV_2906|M.avium_104 QS----AASDLPAQL-----------------------------------
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQA-----------------------------------
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_0669|M.abscessus_ATCC_1997 DVPGSPDQIMKMLQG---------------------------FQQWFEKM
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
Rv1168c|M.tuberculosis_H37Rv -----------------------------------------------YEL
MMAR_1461|M.marinum_M -----------------------------------------------SPL
MUL_3072|M.ulcerans_Agy99 -----------------------------------------------AGL
MAV_2906|M.avium_104 -----------------------------------------------STL
MLBr_01182|M.leprae_Br4923 -----------------------------------------------ISQ
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGP------FLLAVVYQA----VSWVGASI
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGP------FLAAVAYQA----VSWVGASI
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWP------FLFGVAYQVFFNLVGWPTWGM
MAB_0669|M.abscessus_ATCC_1997 G--------FNPATSAVLAVIML------FLYDLLWYP---------YYA
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
Mb1201c|M.bovis_AF2122/97 -GRAGQTL------------------------------------------
Rv1168c|M.tuberculosis_H37Rv IGSVSETVGSFAAP-----------------ATKNLP------------S
MMAR_1461|M.marinum_M IAVVPNALQGMATSGN------------PAAAIAGLPDVALPAGIITDLQ
MUL_3072|M.ulcerans_Agy99 ITSVPNALQTLATTSA------------APTAASILPEVSLPPWLATNLA
MAV_2906|M.avium_104 IDVTPTMLQGLATT---------------PSAAAATPAASIIEAIYPITA
MLBr_01182|M.leprae_Br4923 AALDQAVNEGMEATVVP-------QVDQQVNVDVATPQTAVPDSSSAAAP
Mflv_0325|M.gilvum_PYR-GCK LYPSLFLLPLLATT-------LAIVAGVGQHLLSLLNTPPAEEAAEEPAP
Mvan_0415|M.vanbaalenii_PYR-1 LYPSLLLLPLVATT-------LAIVLGVGAYLLENLPAPAEDAPAEEPAA
MSMEG_0619|M.smegmatis_MC2_155 IFASPFLIPALAALG-----ITGLVLLIDHVLNNPVDVPAEDEAPQEVAA
MAB_0669|M.abscessus_ATCC_1997 SYLLPFLIPALSGLS-----GLAALMHLRPAAPGPVPA-AALSPGDRPIR
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
Rv1168c|M.tuberculosis_H37Rv KLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQ-MMGNLAMRSLTP
MMAR_1461|M.marinum_M NFTTILDTLDGPFTIQGLTGVPGGPFLAFGQVYAFSQNMVGAQAFFSPAE
MUL_3072|M.ulcerans_Agy99 NWNTIMATLTGPFSLQGISSIPGGPFLSFGQVYAYVQNAQGLNAFYSP-K
MAV_2906|M.avium_104 ALRPFFAAVTGAYSPIGAIILPGGWWLLSLQALGLAQNAPGVAELLGGGK
MLBr_01182|M.leprae_Br4923 QLWGGFAQHLSPINDTLSMINNHAGMANAGLSLVNGMGSAMKSLAPTTTK
Mflv_0325|M.gilvum_PYR-GCK AQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAAT
Mvan_0415|M.vanbaalenii_PYR-1 SSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATAS
MSMEG_0619|M.smegmatis_MC2_155 AP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAAT
MAB_0669|M.abscessus_ATCC_1997 RPTQHVEPNLAALPLPTSSVVPSGGSSVPVSTPTAPAHTVSSVPAPSAA-
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTG-SAAPTTGTAPGGAGSPPPAGHSVP
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
Rv1168c|M.tuberculosis_H37Rv TLKGPLELLP-------------NAVRPAVSATLGNADTIGGLSVPPSWV
MMAR_1461|M.marinum_M PVIGGLAPLAGEANLGAAGVVGGPSVGGQASGAMGHAALVGNMSVPQGWT
MUL_3072|M.ulcerans_Agy99 AITGTLAPLVPEISPGGVGLTS-ASVSNSVSGTMGRAALVGSMSVPQGWT
MAV_2906|M.avium_104 AIAGGLSPLAPLRG-GYVSAVT-PDAGG-VAGSMGRSTLVGSLSVPPGWT
MLBr_01182|M.leprae_Br4923 AAESAFKAMGSAVQSTGRGLLG-SSSGGHVTAQLGRAASIGSLRVPQTWT
Mflv_0325|M.gilvum_PYR-GCK FVPYVVAGRDP-YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKR
Mvan_0415|M.vanbaalenii_PYR-1 FVPYAVAGRDP-GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKR
MSMEG_0619|M.smegmatis_MC2_155 FVPYAVANRDP-GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKR
MAB_0669|M.abscessus_ATCC_1997 -ISYAIPGLVPPGVSFGPKSTEKSSESAVDTVAAVAAARGAVAAQARRRL
TH_3113|M.thermoresistible__bu PAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAA
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
Rv1168c|M.tuberculosis_H37Rv ADK-------SITPLAKAVPTSAPGGPSGTSWAQLGLASLAG-GAVGAVA
MMAR_1461|M.marinum_M QEAPAIRVFVSELPTSVTAAPAATLAGESAVFNQMALSSLAG-RALGTGA
MUL_3072|M.ulcerans_Agy99 QAAPAMRLVSSVLSTNLAAAPTAGLPGEAGVFGQMALSSLAG-RAMGAST
MAV_2906|M.avium_104 TAAPVLRTVASVLPAASSATAAAMPASGGAVFGEMAAASLAG-RALAGAG
MLBr_01182|M.leprae_Br4923 TAS-----------QPVTAATRALSPARVAVATESESAPLLG-GGLPMAP
Mflv_0325|M.gilvum_PYR-GCK RRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 RRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 RRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTG
MAB_0669|M.abscessus_ATCC_1997 RGKNKAEAGGR--RHEYLEETAGMGAT-ATADVPAYAATGRGTGPLGFAG
TH_3113|M.thermoresistible__bu AARESAPIRRRRGQKDGLHGHRHEHQQPASMS-AATAPSAAGIRVLGGAG
Mb1201c|M.bovis_AF2122/97 --------------------------------------------------
Rv1168c|M.tuberculosis_H37Rv ARTRSGVILRSPAAG-----------------------------------
MMAR_1461|M.marinum_M FGSGGGGGASKAIGGVVAEADPAAATIIVIPAIED---------------
MUL_3072|M.ulcerans_Agy99 FGSSSGGAVANSLGGVVAEADPAAATIIVIPALDE---------------
MAV_2906|M.avium_104 VRTVGNG-TTGAATAAAADGAATTATIIVVPAD-----------------
MLBr_01182|M.leprae_Br4923 MVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG------------------
Mflv_0325|M.gilvum_PYR-GCK TVSRGD-EQAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGH
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA-AQAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERH
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD-VTAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SP
MAB_0669|M.abscessus_ATCC_1997 TAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD-------------
TH_3113|M.thermoresistible__bu RISRTR-GSVPHAEITPGDPTEPSSPTDRAHRPAEPN-------------
Mb1201c|M.bovis_AF2122/97 ---------
Rv1168c|M.tuberculosis_H37Rv ---------
MMAR_1461|M.marinum_M ---------
MUL_3072|M.ulcerans_Agy99 ---------
MAV_2906|M.avium_104 ---------
MLBr_01182|M.leprae_Br4923 ---------
Mflv_0325|M.gilvum_PYR-GCK DGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 NHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDPEGGPRR
MAB_0669|M.abscessus_ATCC_1997 ----GGDQN
TH_3113|M.thermoresistible__bu ---------