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APLSPTAQRAPLLAAGFTTAFGAHAVAGTLGTTTTGTAASLLTLGAMLAIYDGAEVILKPLFGTLADRIG ARTVLIAGLAVFAVASLSFAVADETAWLWAARLGQGIGAAAFSPAASALVARLAPASGQGRAFGTYGSYK SVGYTLGPLIGGAIVTFGGLQALFAVMAALAAAVAVWAAVAVPRLAVLPRTRQTLLDTVRRFSESSFVTP TLALAAATAALSAGVGFLPVLGTDFGLSPVVTGAVVSVLALTTAVVQPLAGRAADSGRISLTSGLFTGVV VTAAGVAAAALPGLVGLLGGAVVIGVGCGLITPLAFTMLARSTPEERLGQTMGAAEIGRECGDAAGPLVV AAIAAASTVPFGFLGLAAVVAASGVGVRRGRGRVGGVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1475 | - | - | 100% (389) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_4405 | - | 2e-18 | 24.94% (385) | major facilitator transporter |
| M. gilvum PYR-GCK | Mflv_0642 | - | 2e-17 | 23.80% (395) | EmrB/QacA family drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 2e-18 | 26.72% (363) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv2333c | - | 3e-18 | 26.72% (363) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-14 | 25.19% (405) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_3449c | - | 3e-21 | 27.75% (382) | putative transporter |
| M. marinum M | MMAR_0690 | - | 8e-24 | 27.01% (385) | putative transport protein |
| M. avium 104 | MAV_3974 | - | 1e-18 | 24.86% (366) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_1455 | - | 3e-22 | 27.17% (449) | putative multidrug resistance protein |
| M. thermoresistible (build 8) | TH_3965 | - | 5e-22 | 27.84% (370) | PUTATIVE drug transporter |
| M. ulcerans Agy99 | MUL_3826 | - | 3e-15 | 26.50% (366) | hypothetical protein MUL_3826 |
| M. vanbaalenii PYR-1 | Mvan_1322 | - | 3e-22 | 26.91% (431) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1455|M.smegmatis_MC2_155 -------------------------------MTDVRQTPTPDAAPPTGAD
Mvan_1322|M.vanbaalenii_PYR-1 -------------------------------MTDTHR----------GDD
Mb2361c|M.bovis_AF2122/97 ------------------------------------------------MN
Rv2333c|M.tuberculosis_H37Rv ------------------------------------------------MN
MAB_3449c|M.abscessus_ATCC_199 -----------------------------------MSSCREGNADNATVK
MAV_3974|M.avium_104 --------------------------------------------------
TH_3965|M.thermoresistible__bu --------------------------VTSVDAGRSTMSEVFTAYAPRSAA
MUL_3826|M.ulcerans_Agy99 ------------------------MMRPRATVAAATPTTDLAAGRALITP
MMAR_0690|M.marinum_M -----------------------------------------------MTD
Mflv_1475|M.gilvum_PYR-GCK -----------------------------------------------MAP
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MSMEG_1455|M.smegmatis_MC2_155 TGTPLGLAALLAG--TLVGTVSNNVVNVPLDAIIGEFDASLGNGVFVVVG
Mvan_1322|M.vanbaalenii_PYR-1 GGTPLALAALLSG--TLVGTISNNVVNVPMPAILADFDAPLESGVFIVVG
Mb2361c|M.bovis_AF2122/97 RTQLLTLIATGLG--LFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Rv2333c|M.tuberculosis_H37Rv RTQLLTLIATGLG--LFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
MAB_3449c|M.abscessus_ATCC_199 PRLPWEIWVLVVA--SLVIALGFGVVAPALPQYARSFGVSVTAATAVVSS
MAV_3974|M.avium_104 -----------------MVALGYGVISPALPTFARSFGVSIKAVTFLVTV
TH_3965|M.thermoresistible__bu ANPWHALWAMLIG--FFMILVDATIVPVANLEIMADLGADYTAVIWVTSA
MUL_3826|M.ulcerans_Agy99 RRRNFIFVALVLG--ILLSSLDQTIVAIALPTIVADLGEAGR-QSWVVTS
MMAR_0690|M.marinum_M SSRRVVLAAVGFT--FFIDMLVYGIVVPVLPRLAKPAGLEFLGVGVVFAC
Mflv_1475|M.gilvum_PYR-GCK LSPTAQRAPLLAA--GFTTAFGAHAVAGTLGTTTTGTAASLLTLGAMLAI
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
.
MSMEG_1455|M.smegmatis_MC2_155 FLVCFAATIPLAGWFGDRFGRRRVYCAALLATAVCAVGAATAPSLPLLIA
Mvan_1322|M.vanbaalenii_PYR-1 FLLTFTATMPVVGWIGDRIGRRRVYCASMIGTALCAIGAATAPTLELLIL
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
MAB_3449c|M.abscessus_ATCC_199 FAAFRLVFAPVAGALVQRLGERWVYMSGLLIVAASTGICAFVHSYWQLLV
MAV_3974|M.avium_104 FSLSRLCFAPISGLLTERLGERRIYIGGLLIVAVSTAACAFSQAYWQLML
TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLIA
MUL_3826|M.ulcerans_Agy99 YLLASTIATALVGKLGDMFGRKRVFQVAVLLFVAGSVSCGLTQSMTMLVA
MMAR_0690|M.marinum_M YGLAYFVLTPVAGWLIDRRGSRSVFLSGAIILMLATLAFGYASSPVGLVT
Mflv_1475|M.gilvum_PYR-GCK YDGAEVILKPLFGTLADRIGARTVLIAGLAVFAVASLSFAVADETAWLWA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
: . : : * : . : . *
MSMEG_1455|M.smegmatis_MC2_155 WRSVGGVAAAAFAPAVMGLLAWMFSGARR-GRAMGAWASVNGIGQAVGPS
Mvan_1322|M.vanbaalenii_PYR-1 WRCLGGLAASALGPAVMGLLTWLFAGERR-GRAVGAWASVNGIGQAIGPT
Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
MAB_3449c|M.abscessus_ATCC_199 FRSVGGVGSTMFTVSAAALLVRIAPEEIR-GRAQGLYGSSFLLGMVAGPA
MAV_3974|M.avium_104 CRVFSGVGSTMFYVSALGLMIHISPADAR-GRIAGLFTTSFMVGAVGGPA
TH_3965|M.thermoresistible__bu ARVLQGLGAALLTPQTLSMITRIFPADRR-GVPMGVWGATAGVATLIGPL
MUL_3826|M.ulcerans_Agy99 SRALQGVGGGAITVTAIALIGEVVPLRDR-GRYQGILGAVIGIATIGGPL
MMAR_0690|M.marinum_M CRVLQGGAAAATWVAGYATLVEIFPREQR-GRAVGLASIGTALGALLGPA
Mflv_1475|M.gilvum_PYR-GCK ARLGQGIGAAAFSPAASALVARLAPASGQ-GRAFGTYGSYKSVGYTLGPL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
* * .. . : . . :. *
MSMEG_1455|M.smegmatis_MC2_155 LGGLVADHWGWRWIFVPLVPVALAGFVGTLRYVPKFPGARMR-FDLAGAA
Mvan_1322|M.vanbaalenii_PYR-1 MGGFIADAWGWRWVFVPLVPVALAGLIGTLRHIPRYPGTRMS-FDAVGAT
Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
MAB_3449c|M.abscessus_ATCC_199 LGSAVVG-------------------------------------------
MAV_3974|M.avium_104 VGGLAAG-------------------------------------------
TH_3965|M.thermoresistible__bu AGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLPRQDQG-FDVLGMV
MUL_3826|M.ulcerans_Agy99 LGGYFTDCLGWRWAFWINLPVSAVVICVATAAIPALAATTRPVIDYAGIM
MMAR_0690|M.marinum_M LGGLAYEASG----------------------------------------
Mflv_1475|M.gilvum_PYR-GCK IGGAIVTFGG----------------------------------------
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI
*.
MSMEG_1455|M.smegmatis_MC2_155 ALTFGSALLMLGLAIVPQP-NVSGWAAAGSVALGVVALVWFCFHCARVPN
Mvan_1322|M.vanbaalenii_PYR-1 ALTVGSGLLILGVALIPRL-GVS-VAVLSAIAVAVVVLAFFVWHCLRTPE
Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQI-GWTSVQTIVMLWTAAVGCALFVWLERRSSN
Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQI-GWTSVQTIVMLWTAAVGCALFVWLERRSSN
MAB_3449c|M.abscessus_ATCC_199 -LSLSAPFIIYAAALVI---------VVMLVYFGLRRSTLLDVADEHHGT
MAV_3974|M.avium_104 -WGLTAPFVVYGVAMLG---------VALVLFLGLRNSALAAPPPPTRST
TH_3965|M.thermoresistible__bu LSAVGLFLIVFALQEAQTH-RWAPWIWGTLAGGAGVMAMFVIWQSANRRH
MUL_3826|M.ulcerans_Agy99 FIGLSLAALTLATSLGGSVYAWGSAPIIGLFTAAGVTLAVFVWVETIAAQ
MMAR_0690|M.marinum_M ---------PHAPFLGAAG--------LSALAVAALAASLPQAAGGQASG
Mflv_1475|M.gilvum_PYR-GCK ------LQALFAVMAALAA---------AVAVWAAVAVPRLAVLPRTRQT
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEK-GWISLTTIGSGLVALVAAIAFAVVERTAEN
. .
MSMEG_1455|M.smegmatis_MC2_155 PFVNVRLVTESRFARSALAAFAQMFCLGAT-LLAVPLYLVAH-AVSISTA
Mvan_1322|M.vanbaalenii_PYR-1 PFVDVRLVAESRFARSTLAAFAFMFGLGAT-LLAVPLYLVDR-GRSGSVA
Mb2361c|M.bovis_AF2122/97 PMMDLTLFRDTSYALAIATICTVFFAVYGM-LLLTTQFLQNVRGYTPSVT
Rv2333c|M.tuberculosis_H37Rv PMMDLTLFRDTSYALAIATICTVFFAVYGM-LLLTTQFLQNVRGYTPSVT
MAB_3449c|M.abscessus_ATCC_199 PVRLTSALRHRTFLAALMSNFSAGWAIFGIRGALLPLLVVEALHQRPGAA
MAV_3974|M.avium_104 -VTMREALRVRAYQSALLSNFATGWSAFGLRMALVPLFVSDVMGRGIGTI
TH_3965|M.thermoresistible__bu PLVPLQIFADRNFMLANVGVATIGFVVTAM-VLPAMFFAQAVCGLSPTGS
MUL_3826|M.ulcerans_Agy99 PILPIRLFAAPVFSVCCVLAFVVGFAMLGA-LIFVPTFMQYVNGVSATAS
MMAR_0690|M.marinum_M PGMWSGERAFPGLAVPWLVAGLAVGLALGAVEATLPIDLVARFDASGVTV
Mflv_1475|M.gilvum_PYR-GCK LLDTVRRFSESSFVTPTLALAAATAALSAG--VGFLPVLGTDFGLSPVVT
MLBr_01562|M.leprae_Br4923 PVVPFDLFRDRNRLVTFIAIFLAGGVIFSL-TVSIGLYIQDILGYSALRA
.
MSMEG_1455|M.smegmatis_MC2_155 GLVLFTVPVAMAVLGPVVGRRQDRLG--PRLVLRVGLVVLLAVQIALAVT
Mvan_1322|M.vanbaalenii_PYR-1 GLVLLAVPASMTVLGPLVGRYLDRIG--PRRVLRTGLLLMAAGQVGLAVA
Mb2361c|M.bovis_AF2122/97 GLMILPFSAAVAIVSPLVGHLVGRIG--ARVPILAGLCMLMLGLLMLIFS
Rv2333c|M.tuberculosis_H37Rv GLMILPFSAAVAIVSPLVGHLVGRIG--ARVPILAGLCMLMLGLLMLIFS
MAB_3449c|M.abscessus_ATCC_199 GLVFAAFAAGDVSTAFLAGSWSDDIG--RKPLVVAGLVVCGSTVVAMGFV
MAV_3974|M.avium_104 GVVLAAFAGGNALAVVPSGYLSDRMG--RRTLLIVGLVTSGAATVWLGFV
TH_3965|M.thermoresistible__bu ALLIAPMAVASGVLAPMAGRIVDRSH--PTPVVGFGFSVVAVGLTWLAVE
MUL_3826|M.ulcerans_Agy99 GLRILPMVIGMLITSIGSGSMVGRTGR-YKIFPVLGTALMTLAFLLMSRT
MMAR_0690|M.marinum_M GLLFALTTVAFIVTSQYAGRLSDAGR--RAPVLAAGWVTLGVALAVMGVP
Mflv_1475|M.gilvum_PYR-GCK GAVVSVLALTTAVVQPLAGRAADSGRISLTSGLFTGVVVTAAGVAAAALP
MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFSP-RVLTIGGGWLLMVAMLYGWAFM
. . . . *
MSMEG_1455|M.smegmatis_MC2_155 VA---QDRLL-LGVLIAALVTAGVGIALVQTPAATG-ATRSPAGAEGTGL
Mvan_1322|M.vanbaalenii_PYR-1 VGGRIADRVHGLAGLTAILVVVGIGIAFVQTPAATG-ATRSPAGAQGTGL
Mb2361c|M.bovis_AF2122/97 EHR-------SSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMAS
Rv2333c|M.tuberculosis_H37Rv EHR-------SSALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMAS
MAB_3449c|M.abscessus_ATCC_199 SS---------LPVLVVLSLIGGIGAGLYASPQQAAVADVVGSRGR---A
MAV_3974|M.avium_104 AS---------LPVFLVAAGVVGVVTGIYMSPLQAAVADILGNEAR---A
TH_3965|M.thermoresistible__bu MAP-----TTPIWRLVLPFVAVGVGMAFIWSPLATTATRQLPLHLSGAGS
MUL_3826|M.ulcerans_Agy99 DES------TSAAVQSVYLLILGSAIGMSSQVLVIIVQNTSEFEDLGVAT
MMAR_0690|M.marinum_M SAVG---------IQAAALVLLGAGLGAMIATIMPALADAMESAGGAQRP
Mflv_1475|M.gilvum_PYR-GCK GLVG----------LLGGAVVIGVGCGLITPLAFTMLARSTPEERLGQTM
MLBr_01562|M.leprae_Br4923 NRG-----VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVS
* .
MSMEG_1455|M.smegmatis_MC2_155 GLFNLVRFAGSACGAAWVAVALS--GPAS-FPGVFIASAVIVALGLAG-T
Mvan_1322|M.vanbaalenii_PYR-1 GLYNLIRFSGSAMGAAWVAIALAAFGAATGYSAVFLVVGGVAVLGLLG-S
Mb2361c|M.bovis_AF2122/97 GIMSAQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLA-E
Rv2333c|M.tuberculosis_H37Rv GIMSAQRAIGSTIGFAVLGSVLAAWLSATLEPHLERAVPDPVQRHVLA-E
MAB_3449c|M.abscessus_ATCC_199 GTALATFQMTSDIGLVVGPVVAGAIAEHTSYGWAFVVGGAMPLIAAVA-W
MAV_3974|M.avium_104 GLPVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVG-W
TH_3965|M.thermoresistible__bu GVYNTTRQIGSVLGSAGMAAFLTGRLSAELPFGATAVPAGEQTRVLPE-F
MUL_3826|M.ulcerans_Agy99 SGVSLFRTIGGSFGAAIFGSLFVNFLNSRLASALTATEVASSPEALHRQS
MMAR_0690|M.marinum_M GTAAAAYNLAFSAGTVAGGPLAGWMADLRSFQDAAMLIAVVTLTCGVLAA
Mflv_1475|M.gilvum_PYR-GCK GAAEIGRECGDAAGPLVVAAIAAASTVPFGFLGLAAVVAASGVGVRRGRG
MLBr_01562|M.leprae_Br4923 AIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHG
.
MSMEG_1455|M.smegmatis_MC2_155 FFGPDPA-------------------------------------------
Mvan_1322|M.vanbaalenii_PYR-1 FVGPDPAPAR----------------------------------------
Mb2361c|M.bovis_AF2122/97 IIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEG----IRVALLVAT
Rv2333c|M.tuberculosis_H37Rv IIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEG----IRVALLVAT
MAB_3449c|M.abscessus_ATCC_199 VFAPETLGRLASPQVRSMQEVAEDVGGPER--------------------
MAV_3974|M.avium_104 VMAPET--RTATELEADLMAASRTSSRCEQQL------------------
TH_3965|M.thermoresistible__bu LHAPYAAAMAQSMLLPAFVALFGVLAAIFLAGIVLSTPQPDADAQYLDEH
MUL_3826|M.ulcerans_Agy99 PAVAAPIVHAYAGSLAQVFLCAAPVAAIGFVLALFMREVPLRDIHNRDHD
MMAR_0690|M.marinum_M LVHAAVVRRAVSDA------------------------------------
Mflv_1475|M.gilvum_PYR-GCK RVGGVG--------------------------------------------
MLBr_01562|M.leprae_Br4923 YTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL------
MSMEG_1455|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1322|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 ATLAVVFLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG---------
Rv2333c|M.tuberculosis_H37Rv ATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRL
MAB_3449c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_3974|M.avium_104 --------------------------------------------------
TH_3965|M.thermoresistible__bu DDYLVIELARPDPNPRTDIAVTAVIPALRPTLRPTLRPSLGPPGGPVVQP
MUL_3826|M.ulcerans_Agy99 ARVPSGDGSGQQNKLEGDLDTGQSVGAPGKEPDFGVDPAMGPVR------
MMAR_0690|M.marinum_M --------------------------------------------------
Mflv_1475|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
MSMEG_1455|M.smegmatis_MC2_155 -------
Mvan_1322|M.vanbaalenii_PYR-1 -------
Mb2361c|M.bovis_AF2122/97 -------
Rv2333c|M.tuberculosis_H37Rv WPA----
MAB_3449c|M.abscessus_ATCC_199 -------
MAV_3974|M.avium_104 -------
TH_3965|M.thermoresistible__bu NNTAALR
MUL_3826|M.ulcerans_Agy99 -------
MMAR_0690|M.marinum_M -------
Mflv_1475|M.gilvum_PYR-GCK -------
MLBr_01562|M.leprae_Br4923 -------