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VGFAWLPPETNSLRMYLGAGSRPLLAAAGAWDGLAEELHAAASSFGSVTSELAGGAWQGPASAAMANAAG PYASWLTAAGAQAELAARQARAAAGAFEEALAGVVHPAVVQANRVRTWLLAVSNVFGQNAPAIAAMESTY EQMWAQDVAVMAGYHAASSAAAAQLASWQPALPNINLGVGNIGNLNVGNGNTGDYNLGNGNLGNANFGGG NGSAFHGQISSFNVGSGNIGNFNLGSGNGNVGIGPSSFNVGSGNIGNANVGGGNSGDNNFGFGNFGNANI GIGNAGPNMSSPAVPTPGNGNVGIGNGGNGNFGGGNTGNANIGLGNVGDGNVGFGNSGSYNFGFGNTGNN NIGIGLTGSNQIGFGGLNSGSGNIGFGNSGTGNIGFFNSGSGNFGVGNSGVTNTGVANSGNINTGFGNSG FINTGFGNALSVNTGFGNSGQANTGIGNAGDFNTGNFNGGIINTGSFNSGAFNSGSFNGGDANSGFLNSG LTNTGFANSGNINTGGFNAGNLNTGFGNTTDGLGENSGFGNAGSGNSGFNNSGRGNSGAQNVGNLQISGF ANSGQSVTGYNNSVSVTSGFGNKGTGLFSGFMSGFGNTGFLQSGFGNLEANPDNNSATSGFGNSGKQDSG GFNSIDFVSGFFHR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0755c | PPE12 | - | 100% (645) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv3533c | PPE62 | 0.0 | 54.50% (655) | PPE family protein |
| M. tuberculosis H37Rv | Rv2356c | PPE40 | 0.0 | 54.12% (667) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0777c | PPE12 | 0.0 | 99.84% (645) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 8e-31 | 27.63% (637) | triple helix repeat-containing collagen |
| M. leprae Br4923 | MLBr_01182 | - | 1e-34 | 45.95% (185) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-24 | 29.06% (468) | hypothetical protein MAB_4284c |
| M. marinum M | MMAR_4554 | - | 0.0 | 52.92% (686) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 8e-54 | 61.27% (173) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 2e-31 | 28.26% (545) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-26 | 39.43% (175) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 1e-178 | 52.32% (669) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 3e-32 | 29.89% (475) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0777c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4554|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0777c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4554|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0777c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4554|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0777c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4554|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0755c|M.tuberculosis_H37Rv ----------------------------------------MVG--FAWLP
Mb0777c|M.bovis_AF2122/97 ----------------------------------------MVG--FAWLP
MMAR_4554|M.marinum_M -----------------------------------------MN--FSIFP
MUL_0964|M.ulcerans_Agy99 -----------------------------------------MN--FMMLP
MAV_4704|M.avium_104 ----------------------------------------MTNPHFAWLP
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MLBr_01182|M.leprae_Br4923 ------------------------------------------MFDFAALS
TH_3113|M.thermoresistible__bu ----------------------------------------------MALP
MAB_4284c|M.abscessus_ATCC_199 --------------------------MSIIDFILNLFRDPVEAASYVADP
Rv0755c|M.tuberculosis_H37Rv PETN---SLRMYLGAGSRPLLAAAGAWDGLAEELHAAASSFGSVTSELAG
Mb0777c|M.bovis_AF2122/97 PETN---SLRMYLGAGSRPLLAAAGAWDGLAEELHAAASSFGSVTSELAG
MMAR_4554|M.marinum_M PEIN---SLRMFTGAGSAPMLQAAAAWEGLAGELGSAADSFASVTSGLVG
MUL_0964|M.ulcerans_Agy99 PEVN---SALMFTGAGSAPTLAAATAWDGLVAELGEAAEAFSSVTSGLAS
MAV_4704|M.avium_104 PEVN---SALIYSGPGPGPLLAAAAAWDGLAEELASSAQSFSSVTSDLAS
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLGG
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLGS
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWAG
MLBr_01182|M.leprae_Br4923 PETN---STRMYLGPGSSPILTAAAAWVVLAKELTAAAQGLQSAVEALLT
TH_3113|M.thermoresistible__bu PEVH---STLLRTGPGPGALSAAADAWRMLSDEYRAAAVELAAVVSQTCA
MAB_4284c|M.abscessus_ATCC_199 EAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSG
. .
Rv0755c|M.tuberculosis_H37Rv GAWQGPASAAMANAAGPYASWLTAAGAQAELAARQARAAAGAFEEALAGV
Mb0777c|M.bovis_AF2122/97 GAWQGPASAAMANAAGPYASWLTAAGAQAELAARQARAAAGAFEEALAGV
MMAR_4554|M.marinum_M QAWQGPASAAMAAAVAPYTSWLSAAAAQAVGAAGAAKMVASAFEAARAAT
MUL_0964|M.ulcerans_Agy99 GSWQGPAAAAMAAAAAPYAGWLSAAATRALGAATQAKAAAAVFESAQAAT
MAV_4704|M.avium_104 GSWQGASSAAMMTVANQYVSWLSAAAAQAEEVSHQASAIATAFEVALAAT
Mflv_5091|M.gilvum_PYR-GCK GNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGATG
Mvan_1264|M.vanbaalenii_PYR-1 GDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGATG
MSMEG_0868|M.smegmatis_MC2_155 LDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGTG
MLBr_01182|M.leprae_Br4923 -TFEGESAAALAERVTPYEKWLTQNAASAELTATQLTVAANAYETAFTMT
TH_3113|M.thermoresistible__bu TAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLEAAAAAHASALAAM
MAB_4284c|M.abscessus_ATCC_199 NLQNYYAAQPDGPSILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMS
.
Rv0755c|M.tuberculosis_H37Rv VHPAVVQANRVRTWLLAVSNVFGQNAPAIAAMEST------------YEQ
Mb0777c|M.bovis_AF2122/97 VHPAVVQANRVRTWLLAVSNVFGQNAPAIAAMEST------------YEQ
MMAR_4554|M.marinum_M VLPAAVAANRNALVQMVMSNIFGQNAPAIAAAEAA------------YEE
MUL_0964|M.ulcerans_Agy99 VHPELVLANRNQLVSLVLSNLFGQNAPAIAATEST------------YEE
MAV_4704|M.avium_104 VQPAVVAANRALVQALAATNWLGQNTPAIADIEAA------------YEQ
Mflv_5091|M.gilvum_PYR-GCK VTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------A
Mvan_1264|M.vanbaalenii_PYR-1 VTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------A
MSMEG_0868|M.smegmatis_MC2_155 GTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNVT
MLBr_01182|M.leprae_Br4923 VPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAE------------YTE
TH_3113|M.thermoresistible__bu PTMAELTANRTTHAALVATNFFGVNTIPIAVNEAD------------YAR
MAB_4284c|M.abscessus_ATCC_199 PSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVG----------G
. . . .
Rv0755c|M.tuberculosis_H37Rv MWAQDVAVMAGYHAASSAAAAQLASWQPALPNIN----------------
Mb0777c|M.bovis_AF2122/97 MWAQDVAVMAGYHAASSAAAAQLASWQPALPNIN----------------
MMAR_4554|M.marinum_M MWAQDVAAMFGYHSGASAVAAALSPWEQLLQNVP--------------AL
MUL_0964|M.ulcerans_Agy99 LWAQDVAATVGYHGGASAVAAQLAPWQQAIQALPGRVAAMATTGPAASAA
MAV_4704|M.avium_104 MWASDVAAMFGYHADASAAVAKLPPWNEVLQNLG----------------
Mflv_5091|M.gilvum_PYR-GCK VGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG------
Mvan_1264|M.vanbaalenii_PYR-1 VGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG------
MSMEG_0868|M.smegmatis_MC2_155 VGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDGH
MLBr_01182|M.leprae_Br4923 MWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVN----------------
TH_3113|M.thermoresistible__bu MWIQAATTMATYEAVASAAVSATPRTVAPPPILG----------------
MAB_4284c|M.abscessus_ATCC_199 SNSGPIASGQGSTAVNGDVRDSNIINADHGSNVG----------------
.
Rv0755c|M.tuberculosis_H37Rv --LGVG-----NIGNLNVGN----GNTGDYNLGNGNLGNANFGGGNGSAF
Mb0777c|M.bovis_AF2122/97 --LGVG-----NIGNLNVGN----GNTGDYNLGNGNLGNANFGGGNGSAF
MMAR_4554|M.marinum_M SPLAA-------IGNLGAGN-LGFGNTGIANLGNGNTGNLNFGGGN----
MUL_0964|M.ulcerans_Agy99 AALASGPAAALDIGNNGSGNFLSIGNIGNNNLGSGNTGSANLGGGN----
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGLG
Mvan_1264|M.vanbaalenii_PYR-1 -VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTAG
MSMEG_0868|M.smegmatis_MC2_155 AIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGHS
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu -------------------------------AGTGESATAAITGAHVTAE
MAB_4284c|M.abscessus_ATCC_199 -VDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHSQRNTTNINDSFNTDR
Rv0755c|M.tuberculosis_H37Rv HGQISSFNVGSGNIG-----------------------------------
Mb0777c|M.bovis_AF2122/97 HGQISSFNVGSGNIG-----------------------------------
MMAR_4554|M.marinum_M ---IGNFNFGSGNRGG----------------------------------
MUL_0964|M.ulcerans_Agy99 ---IGNGNLGSGNTG-----------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGAG
Mvan_1264|M.vanbaalenii_PYR-1 ETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGVG
MSMEG_0868|M.smegmatis_MC2_155 TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEIY
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu LR------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 STNIGSGNTTNTEIG-----------------------------------
Rv0755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0777c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4554|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------STGAVGG-------VGGKG----IQGGQG-----------
Mvan_1264|M.vanbaalenii_PYR-1 ----------ATGGAGG-------VGGKG----IQGGQG-----------
MSMEG_0868|M.smegmatis_MC2_155 SGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTA
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0755c|M.tuberculosis_H37Rv ---NFNLGSGNGNVGIGPSSFNVGS------------------GNIGNAN
Mb0777c|M.bovis_AF2122/97 ---NFNLGSGNGNVGIGPSSFNVGS------------------GNIGNAN
MMAR_4554|M.marinum_M ---NVNFGNGNN------GFFNLGG------------------GNIGSNN
MUL_0964|M.ulcerans_Agy99 ---NVNLGNGNN------GFFNFGN------------------GNLGDTN
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --LQGGKGGDGGAGGKGGDADSMGS------------------AGATGGK
Mvan_1264|M.vanbaalenii_PYR-1 --LQGGQGGDGGTGGTGGDATSMGE------------------AGATGGK
MSMEG_0868|M.smegmatis_MC2_155 KAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAV
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------AAESRT
MAB_4284c|M.abscessus_ATCC_199 ---SHNQANIGTSTSAGGSAAVGGNAG----------------LAGNAGL
Rv0755c|M.tuberculosis_H37Rv VGGGNSGDNNFGFGN-------------FGNANIGIGNAGPNM-------
Mb0777c|M.bovis_AF2122/97 VGGGNSGDNNFGFGN-------------FGNANIGIGNAGPNM-------
MMAR_4554|M.marinum_M FGSGNRGNGNIGFGNYQSTGGANIGGGNSGSGNKGFGNTGN---------
MUL_0964|M.ulcerans_Agy99 FGSGNSGNLNLGSGN------------RFGSGNIGFGNR-----------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGRGGLFG---------------KGGNAGNGAD-----------
Mvan_1264|M.vanbaalenii_PYR-1 GGNGGNGGRGSLFG---------------RGGNAGNGGN-----------
MSMEG_0868|M.smegmatis_MC2_155 GGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGP
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu LLDEINELIDRLFAP-----------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGN------------AGLAGNAGLAGN-----------
Rv0755c|M.tuberculosis_H37Rv ----------SSPAVPTPGNGNVGIGNGGNGNFGGG--------------
Mb0777c|M.bovis_AF2122/97 ----------SSPAVPTPGNGNVGIGNGGNGNFGGG--------------
MMAR_4554|M.marinum_M ----------YNIGSGNFGSFNFGDGNRGSNNFGFG--------------
MUL_0964|M.ulcerans_Agy99 -----------------FGDGNFGSGNAGSYNFGTG--------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------GGTGGAGGAGGTGG-TGGAGGTGG---------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------GGTGGNGGNGGTGG-TGGNGGTGG---------------
MSMEG_0868|M.smegmatis_MC2_155 AGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQ
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------AGLAGNAGLAGNAGLAGNAGLAGNAG-------------
Rv0755c|M.tuberculosis_H37Rv ---NTGNANIGLGNVGDGNVGFGNSGSYNFGFGNTGNNNIGIGLTGSNQI
Mb0777c|M.bovis_AF2122/97 ---NTGNANIGLGNVGDGNVGFGNSGSYNFGFGNTGNNNIGIGLTGSNQI
MMAR_4554|M.marinum_M ---NTNSGNVGFGNLGANNVGFGNLGSGNVGFGNTGNNNFGIGLSGNDQV
MUL_0964|M.ulcerans_Agy99 ---NNGSFNIGSGNNGDSNIGFGNLGTNNLGFGNNGSNNIGFGLSGSNQI
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
Mvan_1264|M.vanbaalenii_PYR-1 --TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKG
MSMEG_0868|M.smegmatis_MC2_155 TDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRG
MLBr_01182|M.leprae_Br4923 ---EVGLAQEVVEEVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQ
TH_3113|M.thermoresistible__bu -LFPPGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAY
MAB_4284c|M.abscessus_ATCC_199 --LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAG
Rv0755c|M.tuberculosis_H37Rv GFG--GLNSGSGNIGFGNSGTGNIGFFNSGS------------GNFGVGN
Mb0777c|M.bovis_AF2122/97 GFG--GLNSGSGNIGFGNSGTGNIGFFNSGS------------GNFGVGN
MMAR_4554|M.marinum_M GINFNGLNGGSGNIGLFNSGNNNVGFFNSGD------------GNWGIGN
MUL_0964|M.ulcerans_Agy99 GIG--GLNAGIGNMGFGNAGDNNVGFFNSGS------------NNIGFFN
MAV_4704|M.avium_104 -----------------------------------------------FSN
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 GDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGG
MLBr_01182|M.leprae_Br4923 VDQQVNVDVATPQTAVPDSSSAAAPQLWGGF-------------AQHLSP
TH_3113|M.thermoresistible__bu LFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMP---------ALLPVAVAA
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAGNAGLAGNAAVAGNAAVAGNAAVAG--------NAAVGGVLN
Rv0755c|M.tuberculosis_H37Rv SG-----------VTNTGVANSGN--------------------------
Mb0777c|M.bovis_AF2122/97 SG-----------VTNTGVANSGN--------------------------
MMAR_4554|M.marinum_M SG-----------DTNTGIGNSGS--------------------------
MUL_0964|M.ulcerans_Agy99 SG-----------DGNFGFAHAGS--------------------------
MAV_4704|M.avium_104 AS-----------TAVTRPAGSGA--------------------------
Mflv_5091|M.gilvum_PYR-GCK AG-----------DGTGGTGGTGG----TGGQGGQGGQGG----------
Mvan_1264|M.vanbaalenii_PYR-1 AG-----------DGLGGTGGTGG----TGGFGGQGGQGG----------
MSMEG_0868|M.smegmatis_MC2_155 AGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIG
MLBr_01182|M.leprae_Br4923 IN-----------DTLSMINNHAG--------------------------
TH_3113|M.thermoresistible__bu LG--------GLAGVWAGLSGLAG--------------------------
MAB_4284c|M.abscessus_ATCC_199 TG---------VSGAIGGSSHVGG--------------------------
. .
Rv0755c|M.tuberculosis_H37Rv --------------------------------------------------
Mb0777c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4554|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------TGGTGGQGG-LGGGGGTG-----------------------GQ
Mvan_1264|M.vanbaalenii_PYR-1 -------TGGTGGQGG-LGGVGGTG-----------------------GT
MSMEG_0868|M.smegmatis_MC2_155 SNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGH
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Rv0755c|M.tuberculosis_H37Rv ----INTGFGNSGFINT-----------------GFGNALSVNTGFGNSG
Mb0777c|M.bovis_AF2122/97 ----INTGFGNSGFINT-----------------GFGNALSVNTGFGNSG
MMAR_4554|M.marinum_M ----FNTGFVNAASLNTGMANSA-------NTCLGVGNSGAGDVGFMNAG
MUL_0964|M.ulcerans_Agy99 ----TNTGFWNSGGTNT-----------------GFGNGGSLNFGFGNGG
MAV_4704|M.avium_104 ----VARGYTSR--------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGS
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGV
MSMEG_0868|M.smegmatis_MC2_155 GGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGD
MLBr_01182|M.leprae_Br4923 ---MANAGLSLVNGMGS---------------------------------
TH_3113|M.thermoresistible__bu -----LAGLTAVPAADG---------------------------------
MAB_4284c|M.abscessus_ATCC_199 ---AINESLGGSGSVGG---------------STAVGGGAHTGVGGGVST
.
Rv0755c|M.tuberculosis_H37Rv QANTGIGNAGDFNTGNFNGGIINTGSFNSGAFNSGSFNGGDANSGFLNSG
Mb0777c|M.bovis_AF2122/97 QANTGIGNAGDFNTGNFNGGIINTGSFNSGAFNSGSFNGGDANSGFLNSG
MMAR_4554|M.marinum_M HDNVGLGNAGSFNMGFGNAGSGNVGYENAGGANVGFGNSGSDNTGFLNSG
MUL_0964|M.ulcerans_Agy99 VENMGHGNAGSFNMGFG----------NGGGGNTGFYNSGTYNTGFSNAA
MAV_4704|M.avium_104 ------------------------------------------IAGFLAPR
Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKA
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTA
MSMEG_0868|M.smegmatis_MC2_155 GVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTL
MLBr_01182|M.leprae_Br4923 ------------------------------------------AMKSLAPT
TH_3113|M.thermoresistible__bu ---------------------------GASAAPVPAGGPSLPSGSSAPPA
MAB_4284c|M.abscessus_ATCC_199 GVGVGSHVGGGISESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHV
Rv0755c|M.tuberculosis_H37Rv L--TNTGFANSGNINTGGFNAGNLNTG----------------------F
Mb0777c|M.bovis_AF2122/97 L--TNTGFANSGNINTGGFNAGNLNTG----------------------F
MMAR_4554|M.marinum_M S--VNTGFLNSGSTNTGAGNSGEVNTG----------------------F
MUL_0964|M.ulcerans_Agy99 E--TNTGWENSGNVNTGGYNSGGLNTG----------------------I
MAV_4704|M.avium_104 A--PQ---------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK G--ATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGA
Mvan_1264|M.vanbaalenii_PYR-1 G--VTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGS
MSMEG_0868|M.smegmatis_MC2_155 G--GNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGD
MLBr_01182|M.leprae_Br4923 T--TKAAESAFKAMGSAVQSTGRGLLG-----------------------
TH_3113|M.thermoresistible__bu P--TGSAAPTTGTAPGGAGSPPPAGHS----------------------V
MAB_4284c|M.abscessus_ATCC_199 GGGISESLGGSGSVGGSTAVGGGAHTG---------------------VG
Rv0755c|M.tuberculosis_H37Rv GNTTDGLGENSGFG------------NAGSGNSGFNNSGRGNSGAQNVGN
Mb0777c|M.bovis_AF2122/97 GNTTDGLGENSGFG------------NAGSGNSGFNNSGKGNSGAQNVGN
MMAR_4554|M.marinum_M GIATDSGATNSGFG------------NTGSGNSGFNNDGNDNSGFQNT-G
MUL_0964|M.ulcerans_Agy99 GSPDTQAGPNSGFG------------HSGSGNSGFFNSGDGNSGFENS-N
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK TGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
Mvan_1264|M.vanbaalenii_PYR-1 AGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
MSMEG_0868|M.smegmatis_MC2_155 GGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG
MLBr_01182|M.leprae_Br4923 --SSSGGHVTAQLG-----------RAASIGSLRVPQTWTTASQPVTAAT
TH_3113|M.thermoresistible__bu PPAPHSAPPVGTSG--------PPYLIAAQPAPGVARRSAGARRAASIVE
MAB_4284c|M.abscessus_ATCC_199 GGVNTGVGVGSHVG------------GGISESLGGSGSVGGSTAVGGGAH
Rv0755c|M.tuberculosis_H37Rv LQISGFANSGQSVT--------GYNNSV-SVTSGFGNKGTGLFSG-----
Mb0777c|M.bovis_AF2122/97 LQISGFANSGQSVT--------GYNNSV-SVTSGFGNKGTGLFSG-----
MMAR_4554|M.marinum_M TSSEGFGNVGNNQT--------GFQNTG-GTNTGFFNTGTNDVGVGNSAN
MUL_0964|M.ulcerans_Agy99 TCVS-----ANGHS--------GVRNSGDATNVGFSNSGSN---------
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-----
Mvan_1264|M.vanbaalenii_PYR-1 KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-----
MSMEG_0868|M.smegmatis_MC2_155 WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVW
MLBr_01182|M.leprae_Br4923 RALSPARVAVATES------------------------------------
TH_3113|M.thermoresistible__bu PAGSAAAAAAARES--------APIRRRRGQKDGLHGHRHEHQQP-----
MAB_4284c|M.abscessus_ATCC_199 TSAINDALGGSGSVG-------GSTAVGGGAHTSAINESMNSSIN-----
Rv0755c|M.tuberculosis_H37Rv ------FMSGFGNTGFLQSG-------------FGNLEANPDNNSATSGF
Mb0777c|M.bovis_AF2122/97 ------FMSGFGNTGFLQSG-------------FGNLEANPDNNSATSGF
MMAR_4554|M.marinum_M LNIGFWNSTGAGNVGVMNTG-------------TDN-SGFIQTGTANSGF
MUL_0964|M.ulcerans_Agy99 ------------NTGIFNTG-------------TFN-TGIANSGSDSSGL
MAV_4704|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGA
Mvan_1264|M.vanbaalenii_PYR-1 ------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGA
MSMEG_0868|M.smegmatis_MC2_155 KSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGS
MLBr_01182|M.leprae_Br4923 -----------ESAPLLGGG-------------LPMAPMVPGGGSGTGGV
TH_3113|M.thermoresistible__bu -------ASMSAATAPSAAG--------------IRVLGGAGRISRTRGS
MAB_4284c|M.abscessus_ATCC_199 ----------ASHSSSMNES-----------------FGSSMGSHGAAGT
Rv0755c|M.tuberculosis_H37Rv GNSGKQDSGGFNSIDFVSGFFHR------
Mb0777c|M.bovis_AF2122/97 GNSGKQDSGGFNSIDFVSGFFHR------
MMAR_4554|M.marinum_M ANSGTSSSGGLNKGDQQSGFGN-------
MUL_0964|M.ulcerans_Agy99 LISGTNSSGALNSGDDQSGFNN-------
MAV_4704|M.avium_104 -----------------------------
Mflv_5091|M.gilvum_PYR-GCK G--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 G--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNGGNGGADGTPGTAGTTGANNP
MLBr_01182|M.leprae_Br4923 NTALRLQPRAFVMPRNPAAG---------
TH_3113|M.thermoresistible__bu VPHAEITPGDPTEPSSPTDRAHRPAEPN-
MAB_4284c|M.abscessus_ATCC_199 GFEAQGHAQGHASETAHTTLPGAEHH---