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M. tuberculosis H37Rv Rv0507 (mmpL2)

annotation: PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL2
coordinates: 597199 - 600105
length: 968

MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVG
QVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDFWGDPLTAAGSQSADDRAAYV
VVYLVGNNETEAYDSVHAVRHMVDTTPPPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLL
VIYRSVITAVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYHESRY
AGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTV
GSFFKLFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGD
AAAGRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFII
SMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHL
ADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQMRAQMPPM
ISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSP
DGKAARFVIALEGDPATPEGISRVEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGV
AAISLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYN
LLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVV
RSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQHPSATGAHE
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv0507mmpL2-100% (968)PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL2
M. tuberculosis H37RvRv0450cmmpL40.059.30% (946) transmembrane transport protein MmpL4
M. tuberculosis H37RvRv0676cmmpL50.059.00% (939) transmembrane transport protein MmpL5

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0519mmpL20.099.59% (968) transmembrane transport protein MmpL2
M. gilvum PYR-GCKMflv_4418-0.059.40% (926) transport protein
M. leprae Br4923MLBr_02378-0.058.52% (933) hypothetical protein MLBr_02378
M. abscessus ATCC 19977MAB_2301-0.057.13% (947) putative membrane protein, mmpL
M. marinum MMMAR_0840mmpL20.086.59% (962) transmembrane transport protein, MmpL2
M. avium 104MAV_4696-0.059.18% (953) MmpL4 protein
M. smegmatis MC2 155MSMEG_3496-0.059.55% (927) MmpL4 protein
M. thermoresistible (build 8)TH_3260-0.055.21% (940) PUTATIVE MmpL4 protein
M. ulcerans Agy99MUL_0757mmpL50.058.88% (929) transmembrane transport protein, MmpL5
M. vanbaalenii PYR-1Mvan_1936-0.059.29% (926) transport protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_3496|M.smegmatis_MC2_155      -MSNP----SHDAPTDAMGVSGPKHARPGGIAKWIRVLAVPIILVWVAII
TH_3260|M.thermoresistible__bu      MTANPGHVRTDEAPTDRLDIKVSTHG-PSFISTWIRRLSLPIIVGWIALI
MUL_0757|M.ulcerans_Agy99           MTATT-----TDTPTDVVPP--AEHPPRPFIPRMIRTFAVPLILGWVLLI
MLBr_02378|M.leprae_Br4923          -------------MTVKCANDLDTHTKPPFVARMIHRFAVPIILVWLAIA
MAB_2301|M.abscessus_ATCC_1997      -------------MSGSHAG--RSAAEPTFLAKWIRRLSIPIVIGWLAIV
Mflv_4418|M.gilvum_PYR-GCK          ----------------------MADAGRSGIGRIIRVLAVPIVLGWVLLT
Mvan_1936|M.vanbaalenii_PYR-1       ----------------------MADAGRSGIGRIIHLLAVPIVLGWIALT
MAV_4696|M.avium_104                -----------MSEPVEAAPRVDQPLIPPFLPRMIHRLALPIVLVWLGIV
Rv0507|M.tuberculosis_H37Rv         ----------------MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFT
Mb0519|M.bovis_AF2122/97            ----------------MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFT
MMAR_0840|M.marinum_M               ----------------MSDGHTAPASKPPFVPRTIRRFAVLVLLLWLAYT
                                                                  :   *: ::: ::: *:   

MSMEG_3496|M.smegmatis_MC2_155      AVLNTVVPQLDVVGEMRSVSMSPDDAPSVIAMKRVGEVFEEFKSNSSVMI
TH_3260|M.thermoresistible__bu      ALLNITVPQLEVVGEMRAVSMSPDEAPSMVAMKRVGELFDEGSSDSQVMI
MUL_0757|M.ulcerans_Agy99           AVLNSVVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVFREGDSDSAAMI
MLBr_02378|M.leprae_Br4923          VTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNEGNSDSVIMI
MAB_2301|M.abscessus_ATCC_1997      FALNTFVPQLEQVGKEHTVSLSPQSAPSMQAMKHMGKMFKESDSDSVVMI
Mflv_4418|M.gilvum_PYR-GCK          VLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSMKRVGANFEEFDSDSSAMV
Mvan_1936|M.vanbaalenii_PYR-1       VLTNVAVPSLEKVGEEHTVGMSANDAPSMMSMERVGANFDEFDSDSSAMV
MAV_4696|M.avium_104                FITNTVAPQLEVVAKTHSVSMSPTDAASFQSMMKVGATFKEFNSDNSAMI
Rv0507|M.tuberculosis_H37Rv         AFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTI
Mb0519|M.bovis_AF2122/97            AFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTI
MMAR_0840|M.marinum_M               AIVNLAVPQLEVVGKAHSVSMSPSDAESIQAIRHVGRVFGEFDSDNAVTI
                                       .   *.*: *.: ::*.:*.  * *  :: ::*  * * .*:.   :

MSMEG_3496|M.smegmatis_MC2_155      VLEGEQPLGDEAHKYYDEIVDKLEADPAHVEHVQDFWGDPLTASGAQSPD
TH_3260|M.thermoresistible__bu      VLEGEEPLGADARAFYDELVKRLEADDAHVENVQDLWSDPLTATGVQSPD
MUL_0757|M.ulcerans_Agy99           VLEGQEPLGAAAHKFYDKMITKLRADTKHVQSVQDFWGDPLTATGAQSGD
MLBr_02378|M.leprae_Br4923          VLEGDKPLGDDAHRFYDGLIRKLRAD-KHVQSVQDFWGDPLTAPGAQSND
MAB_2301|M.abscessus_ATCC_1997      VLEGQERLGPGSHKFYDEMVARLRADTKHVQHVQDFWGDPLTEAGAQSTD
Mflv_4418|M.gilvum_PYR-GCK          VLEGEQPLGDAAHRYYDQLIDELEADTANVQHIADFWGDPLTASGAQSTD
Mvan_1936|M.vanbaalenii_PYR-1       VLEGEQPLGDAAHRYYDELIGKLEADTANVQHVADFWGDPLTASGAQSTD
MAV_4696|M.avium_104                LLEGDKPLGAEAHRYYDEIVRRVEQDKKHVQHVQDFWSDPLTAAGSQSHD
Rv0507|M.tuberculosis_H37Rv         VLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDFWGDPLTAAGSQSAD
Mb0519|M.bovis_AF2122/97            VLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQHFWGDPLTAAGSQSAD
MMAR_0840|M.marinum_M               VLESDQKLGDEAHHFYSELMKRLKADPRHVAHIQDFWGDPLTAAGSQSAD
                                    :**.:: **  :: :*. :: .:  *  :*  : .:*.**** .* ** *

MSMEG_3496|M.smegmatis_MC2_155      GLASYVQVYTRGNQGEALANESVEAVQDIVESVP---------APPGVKA
TH_3260|M.thermoresistible__bu      GKSAYVQVKLAGNQGEALANESVETVREMIATVSEE------MAPEGVQA
MUL_0757|M.ulcerans_Agy99           GKAAYVQVKLAGNQGESLANESVEAVKTIVDSLQ---------APPGVKV
MLBr_02378|M.leprae_Br4923          GKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTPA---------PPGITA
MAB_2301|M.abscessus_ATCC_1997      GKATYVQVNLAGNMGETLSNESTEAARNIVKQLEADWTKDGNKLPDGLTV
Mflv_4418|M.gilvum_PYR-GCK          GKAAYVQVYLQGNQGEPRANEAVAAVREIVDRTP---------APPGIKA
Mvan_1936|M.vanbaalenii_PYR-1       GKAAYVQVYLQGNQGEPRANEAVAAVREIVDQTP---------APPGLKA
MAV_4696|M.avium_104                QKAAYVQVYLAGNMGGGLANESALAVRKIVDSVP---------APPGIKA
Rv0507|M.tuberculosis_H37Rv         DRAAYVVVYLVGN-NETEAYDSVHAVRHMVDTTP---------PPHGVKA
Mb0519|M.bovis_AF2122/97            DRAAYVVVYLVGN-NETEAYDSVHAVRHMVDTTP---------PPHGVKA
MMAR_0840|M.marinum_M               DKAAYVVVYIVGK-NETEAYASVHAVRHIVDNTP---------APPGLKA
                                      ::** :   *: .   :  :  :.: ::              * *: .

MSMEG_3496|M.smegmatis_MC2_155      YVTGPAALSADQHVASDRSVRVIEALTFAVIITMLLLVYRSIVTVILTLV
TH_3260|M.thermoresistible__bu      FVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFVYRSVITVLIALF
MUL_0757|M.ulcerans_Agy99           YVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSIITAAIMLT
MLBr_02378|M.leprae_Br4923          WVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVILLLF
MAB_2301|M.abscessus_ATCC_1997      YVTGPGALQTDMNHAGDGSLQLITGLTFLVIVVMLLFFYRSIFTVIMVFM
Mflv_4418|M.gilvum_PYR-GCK          YVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIVFRSVATMVLILF
Mvan_1936|M.vanbaalenii_PYR-1       YVTGGAPLVADQHNAGDKSVFRVTLITIGVIAVMLLLVFRSVATMVLILF
MAV_4696|M.avium_104                YVTGAGPLFADQSHAGEKGVAVVTLITFVVIIVMLLVVYRSIITVAVMLG
Rv0507|M.tuberculosis_H37Rv         YVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLI
Mb0519|M.bovis_AF2122/97            YVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLI
MMAR_0840|M.marinum_M               YVTGPSALNADQAEAGDKSIAKVTAITSVVIAVMLLFIYRSVVTAFLVLI
                                    :*** ..: :*   :.: .:  :   :  ** . **..:**. *  : : 

MSMEG_3496|M.smegmatis_MC2_155      MVVLSLSAARGMIAFLGYHEIIGLSVFATNLLTTLAIAAATDYAIFLIGR
TH_3260|M.thermoresistible__bu      MVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIAIAVDYAIFLIGR
MUL_0757|M.ulcerans_Agy99           MVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATDYAIFLIGR
MLBr_02378|M.leprae_Br4923          TVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFITGR
MAB_2301|M.abscessus_ATCC_1997      LVGIQLSAARGVIAFLGNTEIIGLSTFAVNLLVMLSIAAGTDYAIFLIGR
Mflv_4418|M.gilvum_PYR-GCK          MVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIAAGTDYAIFAIGR
Mvan_1936|M.vanbaalenii_PYR-1       MVFAELGAARGIVAFLANAEIIGLSTFATSLLTLMVIAAGTDYAIFAIGR
MAV_4696|M.avium_104                MVFIELAAARGVVATLGNYGVMGLSTFANNMLVLMAIAAGTDYAIFVVGR
Rv0507|M.tuberculosis_H37Rv         MVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGR
Mb0519|M.bovis_AF2122/97            MVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGR
MMAR_0840|M.marinum_M               MVGIDLGAIRGTIAFLANHNIFNLSTFATNLLVLLAIAASTDYAIFMLGR
                                     *     . ** :* *.   ::.**.** .:*. : ** ..**.**  **

MSMEG_3496|M.smegmatis_MC2_155      YQEARSVGEDREQSYYTMFHSTAHVVLGSGMTIAGATLCLHFTRMPYFQS
TH_3260|M.thermoresistible__bu      YQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATFCLSFTRLPYFQS
MUL_0757|M.ulcerans_Agy99           YQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQT
MLBr_02378|M.leprae_Br4923          YQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPYFQT
MAB_2301|M.abscessus_ATCC_1997      YQEARAMGADKEAAYYEMFHGTAHVILGSGMTIAGAMYCLSFTRMPYFQT
Mflv_4418|M.gilvum_PYR-GCK          YQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLPYFQT
Mvan_1936|M.vanbaalenii_PYR-1       YQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLPYFQT
MAV_4696|M.avium_104                YHEARGLGETREQAFYTMFHSTAHVVLGSGLTIAGAMYCLSFCRLPYFQS
Rv0507|M.tuberculosis_H37Rv         YHESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFET
Mb0519|M.bovis_AF2122/97            YHESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFET
MMAR_0840|M.marinum_M               YHEARYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFQT
                                    *:*:*  .  :  ::: *: .* **:*.**:**:**  ** * *:***::

MSMEG_3496|M.smegmatis_MC2_155      LGIPLAIGMSVVVLASLTMGAAIISVASRFGKTFEPKRAMRTRGWRKLGA
TH_3260|M.thermoresistible__bu      LGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKRAARVRFWRKVGA
MUL_0757|M.ulcerans_Agy99           LGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLEPKRMARVRGWRKIGA
MLBr_02378|M.leprae_Br4923          LGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVRGWRRIGT
MAB_2301|M.abscessus_ATCC_1997      LGVPCSVGLLVGVLVSLTLGPALITIGSRFG-LFEPKRAMRIRSWRKIGT
Mflv_4418|M.gilvum_PYR-GCK          MGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKRAISSRGWRRIGV
Mvan_1936|M.vanbaalenii_PYR-1       MGVPCAVGTFVAVMAALTLGPAVVAIGSRFG-LFDPKRAISSRGWRRIGV
MAV_4696|M.avium_104                LGVPCAVGMLVAVLAALTLAPAMLTVASFFK-LMDPKRTLQTRGWRRMGT
Rv0507|M.tuberculosis_H37Rv         LGAPIAIGMLVAVLAALTLGPAVLTVGSFFK-LFDPKRRMNTRRWRRVGT
Mb0519|M.bovis_AF2122/97            LGAPIAIGMLVAVLAALTLGPAVLTVGSFFK-LFDPKRRMNTRRWRRVGT
MMAR_0840|M.marinum_M               LAAPCAIGMLVAVFAALTLGPAVLAVGSAFK-LFDPKRRVNTRRWRRVGT
                                    :. * ::*  : : .:**:..*:: : : *   ::***    * **::*.

MSMEG_3496|M.smegmatis_MC2_155      AVVRWPAPILVTTIALSVVGLLALPGYQTNYNDRRYLPQDLPANTGYAAA
TH_3260|M.thermoresistible__bu      SVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYLPASFPSNAGYEAA
MUL_0757|M.ulcerans_Agy99           AIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRNYLPADLPANEGYSAA
MLBr_02378|M.leprae_Br4923          VVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGFAAA
MAB_2301|M.abscessus_ATCC_1997      TIVRWPGPVLAAAMAIAIIGLAALPGYRTSYDDKKYIPKDIPANAGFQAA
Mflv_4418|M.gilvum_PYR-GCK          SVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYLPEDIPANVGYAVA
Mvan_1936|M.vanbaalenii_PYR-1       SVVRWPGPVLAATLALALVGLVALPGYKTNYDSRDYLPEDVPANVGYAVA
MAV_4696|M.avium_104                AVVRWPAPVLAVTIAVALVGLLALPGYKTDYDNRHFLPADTPANVGYAAA
Rv0507|M.tuberculosis_H37Rv         AIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGDAAA
Mb0519|M.bovis_AF2122/97            AIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGDAAA
MMAR_0840|M.marinum_M               AIVRWPGPVLAATCLVASIGLLALPSYKTTYDLRKFMPSSMPSNVGDAAA
                                     :**** *::  :  :: :** :**.*:* *. : ::* . *:* *  .*

MSMEG_3496|M.smegmatis_MC2_155      DRHFSQARMNPELLMIESDHDLRNSADFLVVDRIAKRVFQVPGISRVQAI
TH_3260|M.thermoresistible__bu      ERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKAVFQVEGISRVQGI
MUL_0757|M.ulcerans_Agy99           ERHFSQARMNPEVLMVESDHDMRNSSDFLVINKIAKAIFGVEGISRVQAI
MLBr_02378|M.leprae_Br4923          DRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPGISRVQAI
MAB_2301|M.abscessus_ATCC_1997      DRHFSQARMNPEMLLIESDHDMRNSADFLVIDKIAKAVFRVPGIARVQAI
Mflv_4418|M.gilvum_PYR-GCK          DQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKSVFRVPGVARVQTI
Mvan_1936|M.vanbaalenii_PYR-1       DRHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKAIFRVPGVARVQTI
MAV_4696|M.avium_104                DRHFDQARLNPELLMIETDHDLRNPADFIVLDKVAKAVFHIPGIGRVQTI
Rv0507|M.tuberculosis_H37Rv         GRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAI
Mb0519|M.bovis_AF2122/97            GRHFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAI
MMAR_0840|M.marinum_M               GRHFSRARLNPEVLMVETNHDMRNPVDMLVLDKVAKNIYHSPGIEQVKSI
                                     ::*  **::**:*::*::**:**. *:::::::*: ::   *: :*: *

MSMEG_3496|M.smegmatis_MC2_155      TRPQGTPIEHTSIPFQISMSGTTQMMNMKYMQDRMADMLVMADEMQKSVD
TH_3260|M.thermoresistible__bu      TRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMADMLVQADEMQLMID
MUL_0757|M.ulcerans_Agy99           TRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSMLQQVNDIQTNID
MLBr_02378|M.leprae_Br4923          TRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAETIA
MAB_2301|M.abscessus_ATCC_1997      TRPQGTPIEHSSIPFLISMQSVGQRQNMKLMKDRMADMKVQADKMGENVV
Mflv_4418|M.gilvum_PYR-GCK          TRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMADMLVQADAMQTNVD
Mvan_1936|M.vanbaalenii_PYR-1       TRPDGKPIKHTTIPFQMSMRSTTSRLNEKYMQDRMADMLVQADAMQTNVD
MAV_4696|M.avium_104                TRPLGTPLDHSTLGFQMGAQAAGRLQTQHYQEEQANNLLKQADELRKTMA
Rv0507|M.tuberculosis_H37Rv         TRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIE
Mb0519|M.bovis_AF2122/97            TRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRIYDILVQVAAMNTSIE
MMAR_0840|M.marinum_M               TRPLGTTIKHTSIPFIISMQGVSSTENMQFMKARMDDMLIQVQAMNVTID
                                    *** *..:.*::: * :.   .      .  :    .:   .  :   : 

MSMEG_3496|M.smegmatis_MC2_155      TMEEMLKITREMSDTTHSMVGKMHGMVEDIKELRDHIADFDDFLRPIRNY
TH_3260|M.thermoresistible__bu      TMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSISEFDDFFRPIRNY
MUL_0757|M.ulcerans_Agy99           QMERMHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIADFDDFFRPIRSY
MLBr_02378|M.leprae_Br4923          SMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPIRSY
MAB_2301|M.abscessus_ATCC_1997      IMKRTLANMTTMAGITHSLVGDMHTLQGTIHEMRDSISNFDDWFRPIRNY
Mflv_4418|M.gilvum_PYR-GCK          TMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNLADFDDFFRPVRNY
Mvan_1936|M.vanbaalenii_PYR-1       TMTKMQSLMTQMSAATHDMVTKTKKTAVDIVEVRDYLANLDDFVRPVRNY
MAV_4696|M.avium_104                TLHEQMQVTQDLSNTTHETTRLTKETVQITERLRDDIANFDDFLRPIRSY
Rv0507|M.tuberculosis_H37Rv         TMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDFFRPIRSY
Mb0519|M.bovis_AF2122/97            TMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDFFRPIRSY
MMAR_0840|M.marinum_M               TMHTMYQLMGEVIDNTVDMDHLTHDMSNITDGLRDRLANFEDFFRPIRSY
                                     :         :   *                :*: :::::*: **:*.*

MSMEG_3496|M.smegmatis_MC2_155      FYWEPHCDSIPVCQSIRSIFDTLDGIDVMTDDIQRLMPDMDRLDELMPQM
TH_3260|M.thermoresistible__bu      FYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNMLPHMHRLNDLMPQM
MUL_0757|M.ulcerans_Agy99           FYWEKHCFDIPVCWSLRSVFDTLDGVDLMTEDINNLLPLMERLDTLMPQM
MLBr_02378|M.leprae_Br4923          FYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLMPQM
MAB_2301|M.abscessus_ATCC_1997      LYWEKHCFDIPMCWAMRSIFDTLDKIDEMTETMDGMVVNMERMDTLMPKM
Mflv_4418|M.gilvum_PYR-GCK          FYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELIPDLERLDELMPQL
Mvan_1936|M.vanbaalenii_PYR-1       FYWEPHCYNIPVCATMRSVFDTLDGINPLTDDIQELIPDLERLDALMPQL
MAV_4696|M.avium_104                FYWEKHCYDIPVCWALRSVFNALDGIDQVAENIVNLSANLDKLDRIQPKL
Rv0507|M.tuberculosis_H37Rv         FYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQM
Mb0519|M.bovis_AF2122/97            FYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQM
MMAR_0840|M.marinum_M               FYWEKHCFDVPLCWSIRQIFDMFDSVDQLSEKLEYLVKDMDMLITLLPKM
                                    :*** ** .:*:* ::*.:*: :* :: : : :  :   :. :  : *::

MSMEG_3496|M.smegmatis_MC2_155      LTIMPPMIESMKTMKTMMLTTQATMGGLQDQMEAAMENQTAMGQAFDASK
TH_3260|M.thermoresistible__bu      LTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQENANAMGEAFDQAR
MUL_0757|M.ulcerans_Agy99           TAMMPEMIQTMKSMKAQMLSMHSTQQGLQDQMAAMQEDSSAMGEAFDSSR
MLBr_02378|M.leprae_Br4923          LEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFDTAK
MAB_2301|M.abscessus_ATCC_1997      VSDMSAMIPIMEDMQRMMLTQHSTMSGFYNQMDEMSQNSTAMGKAFDAAK
Mflv_4418|M.gilvum_PYR-GCK          IALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSEDADAMGEAFDDSM
Mvan_1936|M.vanbaalenii_PYR-1       IALLPSQIESMRNMQSMMLTMYQSQKGLQDQMASQSEDADAMGEAFDDSM
MAV_4696|M.avium_104                VALIPPQIESQQRNLDTIMSNYAITQGLNDQAKAQADNATAQGDAFDKAK
Rv0507|M.tuberculosis_H37Rv         RAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQ
Mb0519|M.bovis_AF2122/97            RAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQ
MMAR_0840|M.marinum_M               RAQIPPMINTMTIMRDMLLVWHGTLQSFYEQQDSGSKDPGAMGRVFDAAQ
                                       :.  :         ::       .  .*     .:  : * .** : 

MSMEG_3496|M.smegmatis_MC2_155      NDDSFYLPPETFENPDFKRGMKMFLSPDGHAVRFIISHEGDPMSPEGIKH
TH_3260|M.thermoresistible__bu      NDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIISHQGDPMTPEGLAK
MUL_0757|M.ulcerans_Agy99           NDDSFYLPPEVFNNPDFKRGLEQFLSPDGHAVRFIISHEGDPMSQAGINH
MLBr_02378|M.leprae_Br4923          NDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAGIAS
MAB_2301|M.abscessus_ATCC_1997      NDDSFYLPPEIFDNADFKRGMKSFLSPDGKAVRMIISHRGDPATPEGLSH
Mflv_4418|M.gilvum_PYR-GCK          NDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIISHEGDPATVEGISE
Mvan_1936|M.vanbaalenii_PYR-1       NDDSFYLPPEAFDNDDFKRGIENFISPDGKSVRFIIAHEGDPATVEGISR
MAV_4696|M.avium_104                NDDTFYLPPEAFKSPDFARGLKNFISPDGRAVRLIISHEGDPASPEGIRH
Rv0507|M.tuberculosis_H37Rv         IDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGISR
Mb0519|M.bovis_AF2122/97            IDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGICR
MMAR_0840|M.marinum_M               IDDSFYLPESAFKNPDFQRGLKMFLSKDGKAARFIIALDGDPATSAGISR
                                     **:**** . *.. ** *.:: *:* **::.*::*   *** :  *:  

MSMEG_3496|M.smegmatis_MC2_155      IDAIKQAAKEAIKGTPLEGSKIYLGGTAATFKDLQEGANYDLIIAGIAAL
TH_3260|M.thermoresistible__bu      IEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDGTKYDLIIAAIAAV
MUL_0757|M.ulcerans_Agy99           IDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGNTFDLMIAGISAL
MLBr_02378|M.leprae_Br4923          INAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGISSL
MAB_2301|M.abscessus_ATCC_1997      VEPIKQAAIEAVKGTPLEDAKIELGGTAAVFKDMSDGAKYDLMIAGISAL
Mflv_4418|M.gilvum_PYR-GCK          VVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDGAFYDLLIAGIAAV
Mvan_1936|M.vanbaalenii_PYR-1       VLPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMRDGANYDLLIAGIAAV
MAV_4696|M.avium_104                IEPIKQAVHEAIKGTPWEGAKVYLGGTAATYKDMHDGSNIDLLIAGIAAA
Rv0507|M.tuberculosis_H37Rv         VEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAI
Mb0519|M.bovis_AF2122/97            VEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAI
MMAR_0840|M.marinum_M               VASIKQEAREAIKGTPLQGAAIYLGGTAATFKDISEGATFDLLIAGVAAI
                                    :  *:  . **:**** :.: : *.**.* :**: :*   **:**.::: 

MSMEG_3496|M.smegmatis_MC2_155      CLIFIIMLIITRAVVASAVIVGTVVISLGASFGLSVLIWQHIIGLELHWM
TH_3260|M.thermoresistible__bu      CLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVLIWQYIVGLEMHWM
MUL_0757|M.ulcerans_Agy99           CLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHVLGIELHWL
MLBr_02378|M.leprae_Br4923          CLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIELHYL
MAB_2301|M.abscessus_ATCC_1997      CLIFLIMLLITRSFVASLVIVGTVALSLGASFGLSVIIWQYILGIELHWL
Mflv_4418|M.gilvum_PYR-GCK          TLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLALHWM
Mvan_1936|M.vanbaalenii_PYR-1       TLIFVIMLIITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLALHWM
MAV_4696|M.avium_104                TLIFIIMLVITRSVVAAFVIVGTVLLSLGASFGLSVLLWQYLLGLKLHWM
Rv0507|M.tuberculosis_H37Rv         SLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWM
Mb0519|M.bovis_AF2122/97            SLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWM
MMAR_0840|M.marinum_M               SLIVIIMMLITRSVVAAAVIVGTVLLSMGSSFGLSVLVWEDILGIELYWM
                                     **.:**:::**:.**: ****** :*:.:***:**::*: ::*: ::::

MSMEG_3496|M.smegmatis_MC2_155      VLAMAVIVLLAVGADYNLLLVSRIKEEIHAGLNTGIIRSMGGTGSVVTSA
TH_3260|M.thermoresistible__bu      VFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMIRAMGGSGSVVTAA
MUL_0757|M.ulcerans_Agy99           VLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVVTAA
MLBr_02378|M.leprae_Br4923          VLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVVTNA
MAB_2301|M.abscessus_ATCC_1997      VMQMAIIVLLAVGSDYNLLLVSRLKEELHGGLKTGIIRSMGGTGSVVTSA
Mflv_4418|M.gilvum_PYR-GCK          VLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGIIRAMAGTGSVVTSA
Mvan_1936|M.vanbaalenii_PYR-1       VLPMAVILLLAVGSDYNLLLVSRFKEELAGGLKTGIIRSMAGTGSVVTSA
MAV_4696|M.avium_104                VLAMAVILLLAVGSDYNLLLISRFKEEIHAGLKTGTIRAMAGSGSVVTSA
Rv0507|M.tuberculosis_H37Rv         VLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAA
Mb0519|M.bovis_AF2122/97            VLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAA
MMAR_0840|M.marinum_M               VLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAA
                                    *: *::*:*****:*****:::*:::*: .*::** **:*.*:* *** *

MSMEG_3496|M.smegmatis_MC2_155      GLVFAFTMMSMAVSELAVIAQVGTTIGLGLLFDTLVIRSFMTPSIAALMG
TH_3260|M.thermoresistible__bu      GLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVVRSFMMPSIATLLG
MUL_0757|M.ulcerans_Agy99           GLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAALLG
MLBr_02378|M.leprae_Br4923          GLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAALLG
MAB_2301|M.abscessus_ATCC_1997      GLVFAFTMAVMVVSDLRIIGQVGTTIALGLLFDTLIVRSFMTPAVATLLG
Mflv_4418|M.gilvum_PYR-GCK          GLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVAALLG
Mvan_1936|M.vanbaalenii_PYR-1       GLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVAALLG
MAV_4696|M.avium_104                GLVFAATMATFMFSPLLVMAQVGTTIALGLLFDTLIVRSFMTPSLATLLG
Rv0507|M.tuberculosis_H37Rv         GMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFMTPSIAALLG
Mb0519|M.bovis_AF2122/97            GMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFMTPSIAALLG
MMAR_0840|M.marinum_M               GMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLIVRSFMTPSIAALLG
                                    *:**. **  : .* * ::.*:****.:******:::**** *::*:*:*

MSMEG_3496|M.smegmatis_MC2_155      KWFWWPQRVRQRPLPAPWPQPVQRDPEDALNRV-----------------
TH_3260|M.thermoresistible__bu      RWFWWPQFVRKRPVPQPWPSVPPRGP-ATTDRVSV---------------
MUL_0757|M.ulcerans_Agy99           KWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV------------------
MLBr_02378|M.leprae_Br4923          RWFWWPQQGRTRPLLTVAAPVGLPPDRSLVYSD-----------------
MAB_2301|M.abscessus_ATCC_1997      RWFWWPLNVRTRPLPPPRTTVAADPTPPPVPVGPGH-------GDDPITT
Mflv_4418|M.gilvum_PYR-GCK          RWFWWPQKFRSAASERRLARIGVQPATAGR--------------------
Mvan_1936|M.vanbaalenii_PYR-1       RWFWWPQKVRSHASQRRLAALNH---------------------------
MAV_4696|M.avium_104                RWFWWPQHVRPRPASTMLRPYGPRRAVRELILADVD-------EHPPGGV
Rv0507|M.tuberculosis_H37Rv         RWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQ---------HPSAT
Mb0519|M.bovis_AF2122/97            RWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQ---------HPSAT
MMAR_0840|M.marinum_M               RWFWWPQRVRPRPASQMLRPSGPRSLVRALLLSPENKSPEGHRLPEPGAP
                                    :*****   *  .                                     

MSMEG_3496|M.smegmatis_MC2_155      ------------------------
TH_3260|M.thermoresistible__bu      ------------------------
MUL_0757|M.ulcerans_Agy99           ------------------------
MLBr_02378|M.leprae_Br4923          ------------------------
MAB_2301|M.abscessus_ATCC_1997      EFPRPSV-----------------
Mflv_4418|M.gilvum_PYR-GCK          ------------------------
Mvan_1936|M.vanbaalenii_PYR-1       ------------------------
MAV_4696|M.avium_104                VQPR--------------------
Rv0507|M.tuberculosis_H37Rv         GAHE--------------------
Mb0519|M.bovis_AF2122/97            GAHE--------------------
MMAR_0840|M.marinum_M               GTPNSSDVTVAGRAPIQPSGELPH