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MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFTAFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVG QVFGEFDSDNAVTIVLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDFWGDPLTAAGSQSADDRAAYV VVYLVGNNETEAYDSVHAVRHMVDTTPPPHGVKAYVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLL VIYRSVITAVLVLIMVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGRYHESRY AGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFETLGAPIAIGMLVAVLAALTLGPAVLTV GSFFKLFDPKRRMNTRRWRRVGTAIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGD AAAGRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAITRPLGTTIKHTSIPFII SMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIETMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHL ADFEDFFRPIRSYFYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQMRAQMPPM ISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQIDDSFYLPQSAFENPDFKRGLKMFLSP DGKAARFVIALEGDPATPEGISRVEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGV AAISLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWMVLAMSVILLLAVGSDYN LLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAAGMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVV RSFMTPSIAALLGRWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQHPSATGAHE
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. tuberculosis H37Rv | Rv0507 | mmpL2 | - | 100% (968) | PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL2 |
M. tuberculosis H37Rv | Rv0450c | mmpL4 | 0.0 | 59.30% (946) | transmembrane transport protein MmpL4 |
M. tuberculosis H37Rv | Rv0676c | mmpL5 | 0.0 | 59.00% (939) | transmembrane transport protein MmpL5 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0519 | mmpL2 | 0.0 | 99.59% (968) | transmembrane transport protein MmpL2 |
M. gilvum PYR-GCK | Mflv_4418 | - | 0.0 | 59.40% (926) | transport protein |
M. leprae Br4923 | MLBr_02378 | - | 0.0 | 58.52% (933) | hypothetical protein MLBr_02378 |
M. abscessus ATCC 19977 | MAB_2301 | - | 0.0 | 57.13% (947) | putative membrane protein, mmpL |
M. marinum M | MMAR_0840 | mmpL2 | 0.0 | 86.59% (962) | transmembrane transport protein, MmpL2 |
M. avium 104 | MAV_4696 | - | 0.0 | 59.18% (953) | MmpL4 protein |
M. smegmatis MC2 155 | MSMEG_3496 | - | 0.0 | 59.55% (927) | MmpL4 protein |
M. thermoresistible (build 8) | TH_3260 | - | 0.0 | 55.21% (940) | PUTATIVE MmpL4 protein |
M. ulcerans Agy99 | MUL_0757 | mmpL5 | 0.0 | 58.88% (929) | transmembrane transport protein, MmpL5 |
M. vanbaalenii PYR-1 | Mvan_1936 | - | 0.0 | 59.29% (926) | transport protein |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_3496|M.smegmatis_MC2_155 -MSNP----SHDAPTDAMGVSGPKHARPGGIAKWIRVLAVPIILVWVAII TH_3260|M.thermoresistible__bu MTANPGHVRTDEAPTDRLDIKVSTHG-PSFISTWIRRLSLPIIVGWIALI MUL_0757|M.ulcerans_Agy99 MTATT-----TDTPTDVVPP--AEHPPRPFIPRMIRTFAVPLILGWVLLI MLBr_02378|M.leprae_Br4923 -------------MTVKCANDLDTHTKPPFVARMIHRFAVPIILVWLAIA MAB_2301|M.abscessus_ATCC_1997 -------------MSGSHAG--RSAAEPTFLAKWIRRLSIPIVIGWLAIV Mflv_4418|M.gilvum_PYR-GCK ----------------------MADAGRSGIGRIIRVLAVPIVLGWVLLT Mvan_1936|M.vanbaalenii_PYR-1 ----------------------MADAGRSGIGRIIHLLAVPIVLGWIALT MAV_4696|M.avium_104 -----------MSEPVEAAPRVDQPLIPPFLPRMIHRLALPIVLVWLGIV Rv0507|M.tuberculosis_H37Rv ----------------MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFT Mb0519|M.bovis_AF2122/97 ----------------MSERHAALTSLPPILPRLIRRFAVVIVLLWLGFT MMAR_0840|M.marinum_M ----------------MSDGHTAPASKPPFVPRTIRRFAVLVLLLWLAYT : *: ::: ::: *: MSMEG_3496|M.smegmatis_MC2_155 AVLNTVVPQLDVVGEMRSVSMSPDDAPSVIAMKRVGEVFEEFKSNSSVMI TH_3260|M.thermoresistible__bu ALLNITVPQLEVVGEMRAVSMSPDEAPSMVAMKRVGELFDEGSSDSQVMI MUL_0757|M.ulcerans_Agy99 AVLNSVVPQLEVVGQMQAVSMSPDAAPSMISMKHIGKVFREGDSDSAAMI MLBr_02378|M.leprae_Br4923 VTVSVFIPSLEDVGQERSVSLSPKDAPSYIAMQKMGQVFNEGNSDSVIMI MAB_2301|M.abscessus_ATCC_1997 FALNTFVPQLEQVGKEHTVSLSPQSAPSMQAMKHMGKMFKESDSDSVVMI Mflv_4418|M.gilvum_PYR-GCK VLTNVAVPSLEKVGEEHTVGMSAGDAPSMMSMKRVGANFEEFDSDSSAMV Mvan_1936|M.vanbaalenii_PYR-1 VLTNVAVPSLEKVGEEHTVGMSANDAPSMMSMERVGANFDEFDSDSSAMV MAV_4696|M.avium_104 FITNTVAPQLEVVAKTHSVSMSPTDAASFQSMMKVGATFKEFNSDNSAMI Rv0507|M.tuberculosis_H37Rv AFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTI Mb0519|M.bovis_AF2122/97 AFVNLAVPQLEVVGKAHSVSMSPSDAASIQAIKRVGQVFGEFDSDNAVTI MMAR_0840|M.marinum_M AIVNLAVPQLEVVGKAHSVSMSPSDAESIQAIRHVGRVFGEFDSDNAVTI . *.*: *.: ::*.:*. * * :: ::* * * .*:. : MSMEG_3496|M.smegmatis_MC2_155 VLEGEQPLGDEAHKYYDEIVDKLEADPAHVEHVQDFWGDPLTASGAQSPD TH_3260|M.thermoresistible__bu VLEGEEPLGADARAFYDELVKRLEADDAHVENVQDLWSDPLTATGVQSPD MUL_0757|M.ulcerans_Agy99 VLEGQEPLGAAAHKFYDKMITKLRADTKHVQSVQDFWGDPLTATGAQSGD MLBr_02378|M.leprae_Br4923 VLEGDKPLGDDAHRFYDGLIRKLRAD-KHVQSVQDFWGDPLTAPGAQSND MAB_2301|M.abscessus_ATCC_1997 VLEGQERLGPGSHKFYDEMVARLRADTKHVQHVQDFWGDPLTEAGAQSTD Mflv_4418|M.gilvum_PYR-GCK VLEGEQPLGDAAHRYYDQLIDELEADTANVQHIADFWGDPLTASGAQSTD Mvan_1936|M.vanbaalenii_PYR-1 VLEGEQPLGDAAHRYYDELIGKLEADTANVQHVADFWGDPLTASGAQSTD MAV_4696|M.avium_104 LLEGDKPLGAEAHRYYDEIVRRVEQDKKHVQHVQDFWSDPLTAAGSQSHD Rv0507|M.tuberculosis_H37Rv VLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQDFWGDPLTAAGSQSAD Mb0519|M.bovis_AF2122/97 VLEGDQPLGGDAHRFYSDLMRKLSADTRHVAHIQHFWGDPLTAAGSQSAD MMAR_0840|M.marinum_M VLESDQKLGDEAHHFYSELMKRLKADPRHVAHIQDFWGDPLTAAGSQSAD :**.:: ** :: :*. :: .: * :* : .:*.**** .* ** * MSMEG_3496|M.smegmatis_MC2_155 GLASYVQVYTRGNQGEALANESVEAVQDIVESVP---------APPGVKA TH_3260|M.thermoresistible__bu GKSAYVQVKLAGNQGEALANESVETVREMIATVSEE------MAPEGVQA MUL_0757|M.ulcerans_Agy99 GKAAYVQVKLAGNQGESLANESVEAVKTIVDSLQ---------APPGVKV MLBr_02378|M.leprae_Br4923 GKAAYVQLSLAGNQGELLAQESIDAVRKIVVQTPA---------PPGITA MAB_2301|M.abscessus_ATCC_1997 GKATYVQVNLAGNMGETLSNESTEAARNIVKQLEADWTKDGNKLPDGLTV Mflv_4418|M.gilvum_PYR-GCK GKAAYVQVYLQGNQGEPRANEAVAAVREIVDRTP---------APPGIKA Mvan_1936|M.vanbaalenii_PYR-1 GKAAYVQVYLQGNQGEPRANEAVAAVREIVDQTP---------APPGLKA MAV_4696|M.avium_104 QKAAYVQVYLAGNMGGGLANESALAVRKIVDSVP---------APPGIKA Rv0507|M.tuberculosis_H37Rv DRAAYVVVYLVGN-NETEAYDSVHAVRHMVDTTP---------PPHGVKA Mb0519|M.bovis_AF2122/97 DRAAYVVVYLVGN-NETEAYDSVHAVRHMVDTTP---------PPHGVKA MMAR_0840|M.marinum_M DKAAYVVVYIVGK-NETEAYASVHAVRHIVDNTP---------APPGLKA ::** : *: . : : :.: :: * *: . MSMEG_3496|M.smegmatis_MC2_155 YVTGPAALSADQHVASDRSVRVIEALTFAVIITMLLLVYRSIVTVILTLV TH_3260|M.thermoresistible__bu FVTGGAAMSADQQEAGDSSLRVIEALTFLVITTMLLFVYRSVITVLIALF MUL_0757|M.ulcerans_Agy99 YVTGSAALVADQQLAGDRSLQLIEMVTFTVIIVMLLLVYRSIITAAIMLT MLBr_02378|M.leprae_Br4923 WVTGASALIADMHHSGDKSMIRITATSVIVILVTLLLVYRSFITVILLLF MAB_2301|M.abscessus_ATCC_1997 YVTGPGALQTDMNHAGDGSLQLITGLTFLVIVVMLLFFYRSIFTVIMVFM Mflv_4418|M.gilvum_PYR-GCK YVTGGAPLVADQHSAGDTSVLRVTLITIGVIAVMLLIVFRSVATMVLILF Mvan_1936|M.vanbaalenii_PYR-1 YVTGGAPLVADQHNAGDKSVFRVTLITIGVIAVMLLLVFRSVATMVLILF MAV_4696|M.avium_104 YVTGAGPLFADQSHAGEKGVAVVTLITFVVIIVMLLVVYRSIITVAVMLG Rv0507|M.tuberculosis_H37Rv YVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLI Mb0519|M.bovis_AF2122/97 YVTGPAALNADQAEAGDKSIAKVTAITSMVIAAMLLVIYRSVITAVLVLI MMAR_0840|M.marinum_M YVTGPSALNADQAEAGDKSIAKVTAITSVVIAVMLLFIYRSVVTAFLVLI :*** ..: :* :.: .: : : ** . **..:**. * : : MSMEG_3496|M.smegmatis_MC2_155 MVVLSLSAARGMIAFLGYHEIIGLSVFATNLLTTLAIAAATDYAIFLIGR TH_3260|M.thermoresistible__bu MVLIGLLTTRGVVAFLGYHNIIGLSTFATSLLVTLAIAIAVDYAIFLIGR MUL_0757|M.ulcerans_Agy99 MVVLGLLATRGGVAFLGYHRIIGLSTFATNLLVVLAIAAATDYAIFLIGR MLBr_02378|M.leprae_Br4923 TVGIESAVARGVVALLGHTGLIGLSTFAVNLLTSLAIAAGTDYGIFITGR MAB_2301|M.abscessus_ATCC_1997 LVGIQLSAARGVIAFLGNTEIIGLSTFAVNLLVMLSIAAGTDYAIFLIGR Mflv_4418|M.gilvum_PYR-GCK MVFAELGAARGIVAFLADAEIIGLSTFATSLLTLMVIAAGTDYAIFAIGR Mvan_1936|M.vanbaalenii_PYR-1 MVFAELGAARGIVAFLANAEIIGLSTFATSLLTLMVIAAGTDYAIFAIGR MAV_4696|M.avium_104 MVFIELAAARGVVATLGNYGVMGLSTFANNMLVLMAIAAGTDYAIFVVGR Rv0507|M.tuberculosis_H37Rv MVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGR Mb0519|M.bovis_AF2122/97 MVGIDLGAIRGFIALLADHNIFSLSTFATNLLVLMAIAASTDYAIFMLGR MMAR_0840|M.marinum_M MVGIDLGAIRGTIAFLANHNIFNLSTFATNLLVLLAIAASTDYAIFMLGR * . ** :* *. ::.**.** .:*. : ** ..**.** ** MSMEG_3496|M.smegmatis_MC2_155 YQEARSVGEDREQSYYTMFHSTAHVVLGSGMTIAGATLCLHFTRMPYFQS TH_3260|M.thermoresistible__bu YQEARSVGADRATAYHTMFGGTAHVILASGLTIAGATFCLSFTRLPYFQS MUL_0757|M.ulcerans_Agy99 YQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQT MLBr_02378|M.leprae_Br4923 YQEARQANENKEAAFYTMYRGTFHVILGSGLTISGATFCLSFARMPYFQT MAB_2301|M.abscessus_ATCC_1997 YQEARAMGADKEAAYYEMFHGTAHVILGSGMTIAGAMYCLSFTRMPYFQT Mflv_4418|M.gilvum_PYR-GCK YQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLPYFQT Mvan_1936|M.vanbaalenii_PYR-1 YQEARGAGEDRETAYYTMFRGTAHVVLGSGLTIAGAMLCLSFTRLPYFQT MAV_4696|M.avium_104 YHEARGLGETREQAFYTMFHSTAHVVLGSGLTIAGAMYCLSFCRLPYFQS Rv0507|M.tuberculosis_H37Rv YHESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFET Mb0519|M.bovis_AF2122/97 YHESRYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFET MMAR_0840|M.marinum_M YHEARYAGEDRETAFYTMFHGTAHVILGSGLTIAGAMYCLSFARLPYFQT *:*:* . : ::: *: .* **:*.**:**:** ** * *:***:: MSMEG_3496|M.smegmatis_MC2_155 LGIPLAIGMSVVVLASLTMGAAIISVASRFGKTFEPKRAMRTRGWRKLGA TH_3260|M.thermoresistible__bu LGPPLAIGMIVLIVTSLTMGPAIITVATRFG-LLEPKRAARVRFWRKVGA MUL_0757|M.ulcerans_Agy99 LGVPLAIGMVIVVATALTLGPALIAVMSRFGKLLEPKRMARVRGWRKIGA MLBr_02378|M.leprae_Br4923 LGVPCAVGMLIAVAVALTLGPAVLTVGSRFG-LFEPKRLIKVRGWRRIGT MAB_2301|M.abscessus_ATCC_1997 LGVPCSVGLLVGVLVSLTLGPALITIGSRFG-LFEPKRAMRIRSWRKIGT Mflv_4418|M.gilvum_PYR-GCK MGVPCAVGTFVAVIAALTLGPAVIVIGSRFG-LFDPKRAISSRGWRRIGV Mvan_1936|M.vanbaalenii_PYR-1 MGVPCAVGTFVAVMAALTLGPAVVAIGSRFG-LFDPKRAISSRGWRRIGV MAV_4696|M.avium_104 LGVPCAVGMLVAVLAALTLAPAMLTVASFFK-LMDPKRTLQTRGWRRMGT Rv0507|M.tuberculosis_H37Rv LGAPIAIGMLVAVLAALTLGPAVLTVGSFFK-LFDPKRRMNTRRWRRVGT Mb0519|M.bovis_AF2122/97 LGAPIAIGMLVAVLAALTLGPAVLTVGSFFK-LFDPKRRMNTRRWRRVGT MMAR_0840|M.marinum_M LAAPCAIGMLVAVFAALTLGPAVLAVGSAFK-LFDPKRRVNTRRWRRVGT :. * ::* : : .:**:..*:: : : * ::*** * **::*. MSMEG_3496|M.smegmatis_MC2_155 AVVRWPAPILVTTIALSVVGLLALPGYQTNYNDRRYLPQDLPANTGYAAA TH_3260|M.thermoresistible__bu SVVRWPGPIMVTTVAVTLVGLLALPGYRTNYNDRNYLPASFPSNAGYEAA MUL_0757|M.ulcerans_Agy99 AIVRWPGPILIGAVALALVGLLTLPGYKTNYNDRNYLPADLPANEGYSAA MLBr_02378|M.leprae_Br4923 VVVRWPLPILITTCAIAMVGLLALPGYRTNYKDRAYLPASIPANQGFAAA MAB_2301|M.abscessus_ATCC_1997 TIVRWPGPVLAAAMAIAIIGLAALPGYRTSYDDKKYIPKDIPANAGFQAA Mflv_4418|M.gilvum_PYR-GCK SVVRWPGPVLAATLALALVGLVTLPGYKTNYDARDYLPEDIPANVGYAVA Mvan_1936|M.vanbaalenii_PYR-1 SVVRWPGPVLAATLALALVGLVALPGYKTNYDSRDYLPEDVPANVGYAVA MAV_4696|M.avium_104 AVVRWPAPVLAVTIAVALVGLLALPGYKTDYDNRHFLPADTPANVGYAAA Rv0507|M.tuberculosis_H37Rv AIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGDAAA Mb0519|M.bovis_AF2122/97 AIVRWPGPVLAATCLVASIGLLALPSYRTTYDLRKFMPASMPSNVGDAAA MMAR_0840|M.marinum_M AIVRWPGPVLAATCLVASIGLLALPSYKTTYDLRKFMPSSMPSNVGDAAA :**** *:: : :: :** :**.*:* *. : ::* . *:* * .* MSMEG_3496|M.smegmatis_MC2_155 DRHFSQARMNPELLMIESDHDLRNSADFLVVDRIAKRVFQVPGISRVQAI TH_3260|M.thermoresistible__bu ERHFDPARLNPELLLIESDHDLRNPADFLVIEKIAKAVFQVEGISRVQGI MUL_0757|M.ulcerans_Agy99 ERHFSQARMNPEVLMVESDHDMRNSSDFLVINKIAKAIFGVEGISRVQAI MLBr_02378|M.leprae_Br4923 DRHFPQARMKPEILMIESDHDMRNPADFLILDKLARGIFRVPGISRVQAI MAB_2301|M.abscessus_ATCC_1997 DRHFSQARMNPEMLLIESDHDMRNSADFLVIDKIAKAVFRVPGIARVQAI Mflv_4418|M.gilvum_PYR-GCK DQHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKSVFRVPGVARVQTI Mvan_1936|M.vanbaalenii_PYR-1 DRHFGSARMNPELLMVESDHDLRNPADFLVIDKIAKAIFRVPGVARVQTI MAV_4696|M.avium_104 DRHFDQARLNPELLMIETDHDLRNPADFIVLDKVAKAVFHIPGIGRVQTI Rv0507|M.tuberculosis_H37Rv GRRFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAI Mb0519|M.bovis_AF2122/97 GRHFSRARLNPEVLLIETDHDMRNPVDMLVLDKVAKNIYHSPGIEQVKAI MMAR_0840|M.marinum_M GRHFSRARLNPEVLMVETNHDMRNPVDMLVLDKVAKNIYHSPGIEQVKSI ::* **::**:*::*::**:**. *:::::::*: :: *: :*: * MSMEG_3496|M.smegmatis_MC2_155 TRPQGTPIEHTSIPFQISMSGTTQMMNMKYMQDRMADMLVMADEMQKSVD TH_3260|M.thermoresistible__bu TRPEGTPIEHSSIPFMISQQGTLQILNQQYMQDRMADMLVQADEMQLMID MUL_0757|M.ulcerans_Agy99 TRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTTSMLQQVNDIQTNID MLBr_02378|M.leprae_Br4923 TRPDGTAMDHTSIPFQISMQNAGQVQTMKYQKDRMNDLLRQAENMAETIA MAB_2301|M.abscessus_ATCC_1997 TRPQGTPIEHSSIPFLISMQSVGQRQNMKLMKDRMADMKVQADKMGENVV Mflv_4418|M.gilvum_PYR-GCK TRPDGKPIKHTTIPFQMSMQGTTQRLNEKYLQDRMADMLVQADAMQTNVD Mvan_1936|M.vanbaalenii_PYR-1 TRPDGKPIKHTTIPFQMSMRSTTSRLNEKYMQDRMADMLVQADAMQTNVD MAV_4696|M.avium_104 TRPLGTPLDHSTLGFQMGAQAAGRLQTQHYQEEQANNLLKQADELRKTMA Rv0507|M.tuberculosis_H37Rv TRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRIDDILVQVAAMNTSIE Mb0519|M.bovis_AF2122/97 TRPLGTTIKHTSIPFIISMQGVNSSEQMEFMKDRIYDILVQVAAMNTSIE MMAR_0840|M.marinum_M TRPLGTTIKHTSIPFIISMQGVSSTENMQFMKARMDDMLIQVQAMNVTID *** *..:.*::: * :. . . : .: . : : MSMEG_3496|M.smegmatis_MC2_155 TMEEMLKITREMSDTTHSMVGKMHGMVEDIKELRDHIADFDDFLRPIRNY TH_3260|M.thermoresistible__bu TMDKMIALMEEMVETTDNMVRDMDEMAAHVAEMRDSISEFDDFFRPIRNY MUL_0757|M.ulcerans_Agy99 QMERMHDLTQQMADVTHQMVIQMKGMVVDVEELRNHIADFDDFFRPIRSY MLBr_02378|M.leprae_Br4923 SMRRMHQLMALLTENTHHILNDTVEMQKTTSKLRDEIANFDDFWRPIRSY MAB_2301|M.abscessus_ATCC_1997 IMKRTLANMTTMAGITHSLVGDMHTLQGTIHEMRDSISNFDDWFRPIRNY Mflv_4418|M.gilvum_PYR-GCK TMTRMQSLMGQMSATTHEMVLKTKKTEIDIIEVRDNLADFDDFFRPVRNY Mvan_1936|M.vanbaalenii_PYR-1 TMTKMQSLMTQMSAATHDMVTKTKKTAVDIVEVRDYLANLDDFVRPVRNY MAV_4696|M.avium_104 TLHEQMQVTQDLSNTTHETTRLTKETVQITERLRDDIANFDDFLRPIRSY Rv0507|M.tuberculosis_H37Rv TMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDFFRPIRSY Mb0519|M.bovis_AF2122/97 TMHRMYALMGEVIDNTVDMDHLTHDMSDITATLRDHLADFEDFFRPIRSY MMAR_0840|M.marinum_M TMHTMYQLMGEVIDNTVDMDHLTHDMSNITDGLRDRLANFEDFFRPIRSY : : * :*: :::::*: **:*.* MSMEG_3496|M.smegmatis_MC2_155 FYWEPHCDSIPVCQSIRSIFDTLDGIDVMTDDIQRLMPDMDRLDELMPQM TH_3260|M.thermoresistible__bu FYWEPHCYNIPVCWAMRSVFDTLDGINTMTDDIQNMLPHMHRLNDLMPQM MUL_0757|M.ulcerans_Agy99 FYWEKHCFDIPVCWSLRSVFDTLDGVDLMTEDINNLLPLMERLDTLMPQM MLBr_02378|M.leprae_Br4923 FYWERHCFNIPICWSFRSIFDALDGVDQIDERLNSIVGDIKNMDLLMPQM MAB_2301|M.abscessus_ATCC_1997 LYWEKHCFDIPMCWAMRSIFDTLDKIDEMTETMDGMVVNMERMDTLMPKM Mflv_4418|M.gilvum_PYR-GCK FYWEPHCYDIPVCWTMRSVFDTLDGINPLTDDISELIPDLERLDELMPQL Mvan_1936|M.vanbaalenii_PYR-1 FYWEPHCYNIPVCATMRSVFDTLDGINPLTDDIQELIPDLERLDALMPQL MAV_4696|M.avium_104 FYWEKHCYDIPVCWALRSVFNALDGIDQVAENIVNLSANLDKLDRIQPKL Rv0507|M.tuberculosis_H37Rv FYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQM Mb0519|M.bovis_AF2122/97 FYWEKHCFDVPLCWSIRSIFDMFDSVDQLSEKLEYLVKDMDILITLLPQM MMAR_0840|M.marinum_M FYWEKHCFDVPLCWSIRQIFDMFDSVDQLSEKLEYLVKDMDMLITLLPKM :*** ** .:*:* ::*.:*: :* :: : : : : :. : : *:: MSMEG_3496|M.smegmatis_MC2_155 LTIMPPMIESMKTMKTMMLTTQATMGGLQDQMEAAMENQTAMGQAFDASK TH_3260|M.thermoresistible__bu LTLLPTTVATMKTMRSMLLTMQATNAGLQDQMAEMQENANAMGEAFDQAR MUL_0757|M.ulcerans_Agy99 TAMMPEMIQTMKSMKAQMLSMHSTQQGLQDQMAAMQEDSSAMGEAFDSSR MLBr_02378|M.leprae_Br4923 LEQFPPMIESMESMRTIMLTMHSTMSGIFDQMNELSDNANTMGKAFDTAK MAB_2301|M.abscessus_ATCC_1997 VSDMSAMIPIMEDMQRMMLTQHSTMSGFYNQMDEMSQNSTAMGKAFDAAK Mflv_4418|M.gilvum_PYR-GCK IALLPSQIETMRSMQAMMLRQYQTQKGQLDQNAAMSEDADAMGEAFDDSM Mvan_1936|M.vanbaalenii_PYR-1 IALLPSQIESMRNMQSMMLTMYQSQKGLQDQMASQSEDADAMGEAFDDSM MAV_4696|M.avium_104 VALIPPQIESQQRNLDTIMSNYAITQGLNDQAKAQADNATAQGDAFDKAK Rv0507|M.tuberculosis_H37Rv RAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQ Mb0519|M.bovis_AF2122/97 RAQMPPMISAMTTMRDMMLIWHGTLGAFYKQQERNNKDPGAMGRVFDAAQ MMAR_0840|M.marinum_M RAQIPPMINTMTIMRDMLLVWHGTLQSFYEQQDSGSKDPGAMGRVFDAAQ :. : :: . .* .: : * .** : MSMEG_3496|M.smegmatis_MC2_155 NDDSFYLPPETFENPDFKRGMKMFLSPDGHAVRFIISHEGDPMSPEGIKH TH_3260|M.thermoresistible__bu NDDSFYLPPEAFDNPDFQRGLEQFLSPDGHAVRFIISHQGDPMTPEGLAK MUL_0757|M.ulcerans_Agy99 NDDSFYLPPEVFNNPDFKRGLEQFLSPDGHAVRFIISHEGDPMSQAGINH MLBr_02378|M.leprae_Br4923 NDDSFYLPPEVFKNTDFKRAMKSFLSSDGHAARFIILHRGDPASVAGIAS MAB_2301|M.abscessus_ATCC_1997 NDDSFYLPPEIFDNADFKRGMKSFLSPDGKAVRMIISHRGDPATPEGLSH Mflv_4418|M.gilvum_PYR-GCK NDDSFYLPPEAFDNDDFKRGMENFISPDGRSVRFIISHEGDPATVEGISE Mvan_1936|M.vanbaalenii_PYR-1 NDDSFYLPPEAFDNDDFKRGIENFISPDGKSVRFIIAHEGDPATVEGISR MAV_4696|M.avium_104 NDDTFYLPPEAFKSPDFARGLKNFISPDGRAVRLIISHEGDPASPEGIRH Rv0507|M.tuberculosis_H37Rv IDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGISR Mb0519|M.bovis_AF2122/97 IDDSFYLPQSAFENPDFKRGLKMFLSPDGKAARFVIALEGDPATPEGICR MMAR_0840|M.marinum_M IDDSFYLPESAFKNPDFQRGLKMFLSKDGKAARFIIALDGDPATSAGISR **:**** . *.. ** *.:: *:* **::.*::* *** : *: MSMEG_3496|M.smegmatis_MC2_155 IDAIKQAAKEAIKGTPLEGSKIYLGGTAATFKDLQEGANYDLIIAGIAAL TH_3260|M.thermoresistible__bu IEPIKKAAVEAIKGTPLEGSRVYLGGTAAVFKDMSDGTKYDLIIAAIAAV MUL_0757|M.ulcerans_Agy99 IDKIKTAAKEAIKGTPLEGSTIYLGGTVAMFKDLSDGNTFDLMIAGISAL MLBr_02378|M.leprae_Br4923 INAIRTAAEEALKGTPLEDTKIYLAGTAAVFKDIDEGANWDLVIAGISSL MAB_2301|M.abscessus_ATCC_1997 VEPIKQAAIEAVKGTPLEDAKIELGGTAAVFKDMSDGAKYDLMIAGISAL Mflv_4418|M.gilvum_PYR-GCK VVPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMSDGAFYDLLIAGIAAV Mvan_1936|M.vanbaalenii_PYR-1 VLPIKTAAKEAIKGTPLEGSTVYLAGTAATYKDMRDGANYDLLIAGIAAV MAV_4696|M.avium_104 IEPIKQAVHEAIKGTPWEGAKVYLGGTAATYKDMHDGSNIDLLIAGIAAA Rv0507|M.tuberculosis_H37Rv VEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAI Mb0519|M.bovis_AF2122/97 VEPIKREAREAIKGTPLQGAAIYLGGTAATFKDIREGARYDLLIAGVAAI MMAR_0840|M.marinum_M VASIKQEAREAIKGTPLQGAAIYLGGTAATFKDISEGATFDLLIAGVAAI : *: . **:**** :.: : *.**.* :**: :* **:**.::: MSMEG_3496|M.smegmatis_MC2_155 CLIFIIMLIITRAVVASAVIVGTVVISLGASFGLSVLIWQHIIGLELHWM TH_3260|M.thermoresistible__bu CLIFIIMLILTRAVVAAAVIVGTVTLSLAASFGVSVLIWQYIVGLEMHWM MUL_0757|M.ulcerans_Agy99 CLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHVLGIELHWL MLBr_02378|M.leprae_Br4923 CLIFIIMLIITRAFVAAAVIVGTVALSLGASFGLSVLLWQHILGIELHYL MAB_2301|M.abscessus_ATCC_1997 CLIFLIMLLITRSFVASLVIVGTVALSLGASFGLSVIIWQYILGIELHWL Mflv_4418|M.gilvum_PYR-GCK TLIFVIMLVITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLALHWM Mvan_1936|M.vanbaalenii_PYR-1 TLIFVIMLIITRSVVAAAVIVGTVLLSLGASFGLSVLLWQHIIGLALHWM MAV_4696|M.avium_104 TLIFIIMLVITRSVVAAFVIVGTVLLSLGASFGLSVLLWQYLLGLKLHWM Rv0507|M.tuberculosis_H37Rv SLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWM Mb0519|M.bovis_AF2122/97 SLILIIMMIITRSVVAAVVIVGTVVLSMGASFGLSVLVWQDILGIELYWM MMAR_0840|M.marinum_M SLIVIIMMLITRSVVAAAVIVGTVLLSMGSSFGLSVLVWEDILGIELYWM **.:**:::**:.**: ****** :*:.:***:**::*: ::*: :::: MSMEG_3496|M.smegmatis_MC2_155 VLAMAVIVLLAVGADYNLLLVSRIKEEIHAGLNTGIIRSMGGTGSVVTSA TH_3260|M.thermoresistible__bu VFPMALIILLAVGADYNLLVVARLREEIPAGLNTGMIRAMGGSGSVVTAA MUL_0757|M.ulcerans_Agy99 VLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVVTAA MLBr_02378|M.leprae_Br4923 VLAMSVIVLLAVGSDYNLLLVSRFKQEIQAGLKTGIIRSMGGTGKVVTNA MAB_2301|M.abscessus_ATCC_1997 VMQMAIIVLLAVGSDYNLLLVSRLKEELHGGLKTGIIRSMGGTGSVVTSA Mflv_4418|M.gilvum_PYR-GCK VLPMAVILLLAVGSDYNLLLVSRFKEELSGGLKTGIIRAMAGTGSVVTSA Mvan_1936|M.vanbaalenii_PYR-1 VLPMAVILLLAVGSDYNLLLVSRFKEELAGGLKTGIIRSMAGTGSVVTSA MAV_4696|M.avium_104 VLAMAVILLLAVGSDYNLLLISRFKEEIHAGLKTGTIRAMAGSGSVVTSA Rv0507|M.tuberculosis_H37Rv VLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAA Mb0519|M.bovis_AF2122/97 VLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAA MMAR_0840|M.marinum_M VLAMSVILLLAVGSDYNLLLISRLKEEIGAGLNTGIIRAMAGTGGVVTAA *: *::*:*****:*****:::*:::*: .*::** **:*.*:* *** * MSMEG_3496|M.smegmatis_MC2_155 GLVFAFTMMSMAVSELAVIAQVGTTIGLGLLFDTLVIRSFMTPSIAALMG TH_3260|M.thermoresistible__bu GLVFGLTMMVMVVSDLTVMGQVGTTIGLGLLFDTFVVRSFMMPSIATLLG MUL_0757|M.ulcerans_Agy99 GLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAALLG MLBr_02378|M.leprae_Br4923 GLVFAFTMASMVVSDLRVIGQVGTTIGLGLLFDTLIVRSFMMPSIAALLG MAB_2301|M.abscessus_ATCC_1997 GLVFAFTMAVMVVSDLRIIGQVGTTIALGLLFDTLIVRSFMTPAVATLLG Mflv_4418|M.gilvum_PYR-GCK GLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVAALLG Mvan_1936|M.vanbaalenii_PYR-1 GLVFAFTMASFAFSDLKVMAQVGTTIALGLLFDTLIVRSFMTPAVAALLG MAV_4696|M.avium_104 GLVFAATMATFMFSPLLVMAQVGTTIALGLLFDTLIVRSFMTPSLATLLG Rv0507|M.tuberculosis_H37Rv GMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFMTPSIAALLG Mb0519|M.bovis_AF2122/97 GMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLVVRSFMTPSIAALLG MMAR_0840|M.marinum_M GMVFAVTMSLFVFSDLRIIGQIGTTIGLGLLFDTLIVRSFMTPSIAALLG *:**. ** : .* * ::.*:****.:******:::**** *::*:*:* MSMEG_3496|M.smegmatis_MC2_155 KWFWWPQRVRQRPLPAPWPQPVQRDPEDALNRV----------------- TH_3260|M.thermoresistible__bu RWFWWPQFVRKRPVPQPWPSVPPRGP-ATTDRVSV--------------- MUL_0757|M.ulcerans_Agy99 KWFWWPQVVRQRPAPQPWPTPAPTPPPATTSV------------------ MLBr_02378|M.leprae_Br4923 RWFWWPQQGRTRPLLTVAAPVGLPPDRSLVYSD----------------- MAB_2301|M.abscessus_ATCC_1997 RWFWWPLNVRTRPLPPPRTTVAADPTPPPVPVGPGH-------GDDPITT Mflv_4418|M.gilvum_PYR-GCK RWFWWPQKFRSAASERRLARIGVQPATAGR-------------------- Mvan_1936|M.vanbaalenii_PYR-1 RWFWWPQKVRSHASQRRLAALNH--------------------------- MAV_4696|M.avium_104 RWFWWPQHVRPRPASTMLRPYGPRRAVRELILADVD-------EHPPGGV Rv0507|M.tuberculosis_H37Rv RWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQ---------HPSAT Mb0519|M.bovis_AF2122/97 RWFWWPLRVRPRPASQMLRPFAPRRLVRALLLPSGQ---------HPSAT MMAR_0840|M.marinum_M RWFWWPQRVRPRPASQMLRPSGPRSLVRALLLSPENKSPEGHRLPEPGAP :***** * . MSMEG_3496|M.smegmatis_MC2_155 ------------------------ TH_3260|M.thermoresistible__bu ------------------------ MUL_0757|M.ulcerans_Agy99 ------------------------ MLBr_02378|M.leprae_Br4923 ------------------------ MAB_2301|M.abscessus_ATCC_1997 EFPRPSV----------------- Mflv_4418|M.gilvum_PYR-GCK ------------------------ Mvan_1936|M.vanbaalenii_PYR-1 ------------------------ MAV_4696|M.avium_104 VQPR-------------------- Rv0507|M.tuberculosis_H37Rv GAHE-------------------- Mb0519|M.bovis_AF2122/97 GAHE-------------------- MMAR_0840|M.marinum_M GTPNSSDVTVAGRAPIQPSGELPH