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KTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLGGHEGAGIVTEV GPGVDDFAPGDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTF SPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGA RYVFAVEPVEWKRDQALKFGATHVYPDINAALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGG TCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAYKLEQI NDGYQDMLNGKNIRGVIRYTDDDR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0761c | adhB | - | 100% (375) | POSSIBLE ZINC-CONTAINING ALCOHOL DEHYDROGENASE NAD DEPENDENT ADHB |
| M. tuberculosis H37Rv | Rv3086 | adhD | 3e-97 | 47.01% (368) | zinc-type alcohol dehydrogenase AdhD |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 2e-54 | 33.98% (362) | zinc-type alcohol dehydrogenase E subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0784c | adhB | 0.0 | 100.00% (375) | zinc-containing alcohol dehydrogenase NAD dependant ADHB |
| M. gilvum PYR-GCK | Mflv_1593 | - | 1e-180 | 79.26% (376) | alcohol dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 2e-42 | 31.25% (368) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_4560 | - | 1e-130 | 58.29% (374) | alcohol dehydrogenase B |
| M. marinum M | MMAR_4935 | adhB | 0.0 | 87.20% (375) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. avium 104 | MAV_0705 | - | 0.0 | 87.20% (375) | alcohol dehydrogenase B |
| M. smegmatis MC2 155 | MSMEG_5866 | - | 0.0 | 80.80% (375) | alcohol dehydrogenase B |
| M. thermoresistible (build 8) | TH_1254 | - | 0.0 | 84.00% (375) | alcohol dehydrogenase B |
| M. ulcerans Agy99 | MUL_0470 | adhB | 0.0 | 86.93% (375) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_5164 | - | 1e-180 | 78.72% (376) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1593|M.gilvum_PYR-GCK ---------MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCH
Mvan_5164|M.vanbaalenii_PYR-1 ---------MKTKGALIWEFNQPWTIEEIEIGDPVKDEVKIQMEASGMCH
MSMEG_5866|M.smegmatis_MC2_155 ---------MKTKGALIWEFNQPWSIEEIEIGDPVKDEVKIQMEASGMCH
TH_1254|M.thermoresistible__bu ---------MKTKGALIWEFNQPWSVEEIEIGDPVKDEVKIRMEASGMCH
Rv0761c|M.tuberculosis_H37Rv ---------MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCR
Mb0784c|M.bovis_AF2122/97 ---------MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCR
MMAR_4935|M.marinum_M ---------MKTKGALIWEFNQPWSVEDIEIGDPVKDEVKIQMEAAGMCR
MUL_0470|M.ulcerans_Agy99 ---------MKTKGALIWEFNQPWSVEDIEIGDPVKDEVKIQMEAAGMCR
MAV_0705|M.avium_104 ---------MKTKGALIWEFNQPWSIEEIEIGDPQAHEVKIQMEAAGMCH
MAB_4560|M.abscessus_ATCC_1997 MYLEGLAESMKTKGALIRELNKPIVVEEITFGDPAEGEVQVQLHAAGMCH
MLBr_01784|M.leprae_Br4923 -------MSQTVRGVISRKKDEPVELVDIVIPDPGPGEAVVDVTACGVCH
..:*.: : ::* : :* : ** *. : : *.*:*:
Mflv_1593|M.gilvum_PYR-GCK SDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVEGLEPGDHVVLSFIPS
Mvan_5164|M.vanbaalenii_PYR-1 SDHHLVTGDIPMAGFPVLGGHEGAGVVTEVGPGVEGLEPGDHVVLSFIPS
MSMEG_5866|M.smegmatis_MC2_155 SDHHLVTGGIPMGGFPVLGGHEGAGIVTEVGPGVEGIEPGDHVVLSFIPS
TH_1254|M.thermoresistible__bu SDHHLVTGGIPMGGFPVLGGHEGAGVVEEVGPGVEEVQPGDHVVLSFIPS
Rv0761c|M.tuberculosis_H37Rv SDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPS
Mb0784c|M.bovis_AF2122/97 SDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPS
MMAR_4935|M.marinum_M SDNHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVDDIAPGDHVVLSFIPS
MUL_0470|M.ulcerans_Agy99 SDNHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVDDIAPGDHVVLSFIPS
MAV_0705|M.avium_104 SDHHLVTGGIPMAGFPVLGGHEGAGIVTEVGPGVEDIAPGDHVVLSFIPS
MAB_4560|M.abscessus_ATCC_1997 SDYHVLTGATPME-LPVLPGHEGAGVVTKVGKGVTSVQEGDHVIFAFIPA
MLBr_01784|M.leprae_Br4923 TDLTYREGGINDR-YPFLLGHEAAGTVEVVGPGVTAVEPGDFVILNWRAV
:* * *.* ***.** * ** ** . **.*:: : .
Mflv_1593|M.gilvum_PYR-GCK CGACPSCQAGLRNLCDLGAMLLQGTAVSDNTHRIHAADGTPVIPMTLLGT
Mvan_5164|M.vanbaalenii_PYR-1 CGSCPSCQAGMRNLCDLGAMLLQGTAVSDNTHRIHAKDGTPVIPMTLLGT
MSMEG_5866|M.smegmatis_MC2_155 CGSCPSCQAGLRNLCDLGAGLLGGVAVADGTHRIHAN-GKPVFPMTLLGT
TH_1254|M.thermoresistible__bu CGQCPSCQAGLRNLCDLGAGLLNGAAVSDGTFRITAR-GQNVYPMTLLGT
Rv0761c|M.tuberculosis_H37Rv CGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQAR-GQNVYPMTLLGT
Mb0784c|M.bovis_AF2122/97 CGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQAR-GQNVYPMTLLGT
MMAR_4935|M.marinum_M CGRCPTCQAGLRNLCDLGAGLLAGAAVSDGTFRIQAR-GQNVYPMTLLGT
MUL_0470|M.ulcerans_Agy99 CGRCPTCQAGLRNLCDLGAGLLAGAAVSDGTFRIQAR-GQNVYPMTLLGT
MAV_0705|M.avium_104 CGSCPTCQAGMRNLCDLGAGLLGGEAVSDGTFRIQAR-GQNVYPMTLLGT
MAB_4560|M.abscessus_ATCC_1997 CGKCPPCMRGYRSLCDRGAILLGGKAIADGTNRIHAG-NTPVSAMNLLGT
MLBr_01784|M.leprae_Br4923 CGQCRACKRGRPSYCFDTFNAQQKMTLIDG---------TELTPALGIGA
** * .* * . * :: *. : . :*:
Mflv_1593|M.gilvum_PYR-GCK FSPYMVVHKSSVVKIDPSIPFEVACLVGCGVTTGYGSAVRSADVRPGDDV
Mvan_5164|M.vanbaalenii_PYR-1 FSPYMVVHKSSVVKIDPSIPFEVACLVGCGVTTGYGSAVRSANVRPGDDV
MSMEG_5866|M.smegmatis_MC2_155 FSPYMVVHKSSVVKIDKSIPFEVACLVGCGVTTGYGSAVRSGDIRPGDDV
TH_1254|M.thermoresistible__bu FSPYMVVHKSSVVKIDKDIPFEVACLVGCGVTTGYGSAVRSGDVRPGDDV
Rv0761c|M.tuberculosis_H37Rv FSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDV
Mb0784c|M.bovis_AF2122/97 FSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDV
MMAR_4935|M.marinum_M FSPYMVVHRSSVVKIDPAIPFEVAALVGCGVTTGYGSAVRTADVRPGDDV
MUL_0470|M.ulcerans_Agy99 FSPYMVVHRSSVVKIDPAIPFEVAALVGCGVTTGYGSAVRTADVRPGDDV
MAV_0705|M.avium_104 FSPYMVVHRSSVVKIDPSIPFEVAALVGCGVTTGYGSAVRTADIRPGQDV
MAB_4560|M.abscessus_ATCC_1997 FSPYAVVHEDSVVKIDDDVPFESAALLGCAVPTGFGSSTNIAEVKPGEDV
MLBr_01784|M.leprae_Br4923 FADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAAINTAAVSRDDTV
*: :** .. .*:* * *:**.* :* *:: . . : .: *
Mflv_1593|M.gilvum_PYR-GCK VIAGIGGVGMGALQGALNAGARNIFAIDPVEWKRDQALKFGATHAYPDIF
Mvan_5164|M.vanbaalenii_PYR-1 VIAGIGGVGMGALQGALNAGARTIFAIDPVEWKRDQALKFGATHAYPDIF
MSMEG_5866|M.smegmatis_MC2_155 AIFGIGGVGMGALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDVF
TH_1254|M.thermoresistible__bu AIVGVGGVGMGALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDIE
Rv0761c|M.tuberculosis_H37Rv AIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
Mb0784c|M.bovis_AF2122/97 AIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDIN
MMAR_4935|M.marinum_M AIVGLGGVGMAALQGAVTAGARYIFAVEPVEWKRDQALKFGATHVYPDME
MUL_0470|M.ulcerans_Agy99 AIVGLGGVGMAALQGAVTAGARYIFAVEPVEWKRDQALKFGATHVYPDME
MAV_0705|M.avium_104 AIVGVGGVGMAALQGAVNAGARYIFAIDPVEWKRDQALKFGATHVYPDIM
MAB_4560|M.abscessus_ATCC_1997 IIVGIGGIGMSALQGAVVSGARRVIAIDPVPWKREQALKFGATHAFPTMA
MLBr_01784|M.leprae_Br4923 AVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWARTFGATHTVNALE
: * **:* .*:.** **. ::*:: * : * .*****. :
Mflv_1593|M.gilvum_PYR-GCK SAMAG-VAELTQGRMAAKTIITTGELHGEEIDNYLNITSKGGTCVVTAVA
Mvan_5164|M.vanbaalenii_PYR-1 SAMAG-VAEVTQGRMASKTIITTGELHGEEIDNYLNITAKGGTCVVTAVA
MSMEG_5866|M.smegmatis_MC2_155 SAMAG-IAEVTAGGMAKKVIVTVGELHGEDIDNYLNVTSKGGTCVVTAVG
TH_1254|M.thermoresistible__bu SAMAG-IAEVTWGLMAKKVIVTVGELKGEDIDAYVNLTAKGGTCVLTAIG
Rv0761c|M.tuberculosis_H37Rv AALMG-IAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIG
Mb0784c|M.bovis_AF2122/97 AALMG-IAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIG
MMAR_4935|M.marinum_M AALMG-IAEVTYGLMAKKVVITVGELQGSDIDTYLAITSKGGTCVVTAIG
MUL_0470|M.ulcerans_Agy99 AALMG-IAEVTYGLMAKKVMITVGELQGSDIDTYLAITSKGGTCVVTAIG
MAV_0705|M.avium_104 AAMAG-MAEVTYGLMAHKVVVTVGELQGADVDNYLNITQKGGTCVLTAIG
MAB_4560|M.abscessus_ATCC_1997 EALLP-VMDLTWGIMAQKTIITVGEMRGEMIEEAMLLTAKTGTCVVTGMG
MLBr_01784|M.leprae_Br4923 LEVVKTIQDLTSGFGVDVVIDTVGRP--ETWKQAFYARDLAGTVVLVGVP
: : ::* * . .: *.*. . . ** *:..:
Mflv_1593|M.gilvum_PYR-GCK NMAKSDVTLNLSMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGRLNLD
Mvan_5164|M.vanbaalenii_PYR-1 NMASSEVTMNLSMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGRLNLD
MSMEG_5866|M.smegmatis_MC2_155 SMLDTNANINLAMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGKLNLD
TH_1254|M.thermoresistible__bu SLLDTQVNLNLSMLTLLQKNLQGTIFGGGNPHHDIPQLLSMYKAGKLNLD
Rv0761c|M.tuberculosis_H37Rv SLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLD
Mb0784c|M.bovis_AF2122/97 SLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLD
MMAR_4935|M.marinum_M SLLDTQVNLNLAMLTLMQKNLQGTIFGGGNPQYDIPQLLSMYKARKLNID
MUL_0470|M.ulcerans_Agy99 SLLDTQVNLNLAMLTLMQKNLQGTIFGGGNPQYDIPHLLSMYKARNLNID
MAV_0705|M.avium_104 SLLDTNVTLNLAMLTLMQKNLQGTIFGGGNPQYDIPQLLSMYKAGKLNLD
MAB_4560|M.abscessus_ATCC_1997 AMVDVDVKFNLFLFTMLQKTLKGNIFGGGTTHTETPRLVGLYKQGLLKID
MLBr_01784|M.leprae_Br4923 -TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLVDLYLQGRLPLG
. : * : .::.. :*. .. : * *:.:* * :.
Mflv_1593|M.gilvum_PYR-GCK DMVTRQYKLEQINDGYKDMLEGKNIRGVIRYTDADR
Mvan_5164|M.vanbaalenii_PYR-1 DMVTRQYKLEQINEGYKDMLEGKNIRGVIRYTDADR
MSMEG_5866|M.smegmatis_MC2_155 DMVTRQYRLEQINDGYQDMLEGRNIRGVIRYTDADR
TH_1254|M.thermoresistible__bu DMVTRQYKLEQINEGYQDMLEGRNIRGVIRYTDDDR
Rv0761c|M.tuberculosis_H37Rv DMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
Mb0784c|M.bovis_AF2122/97 DMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR
MMAR_4935|M.marinum_M DMITRQYRLEQINEGYQDMIDGKNIRGVIRFTDADR
MUL_0470|M.ulcerans_Agy99 DMITRQYRLEQINEGYQDMIDGKNIRGVIRFTDADR
MAV_0705|M.avium_104 DMITRQYRLEQINDGYQDMLDGKNIRGVIRYTDADR
MAB_4560|M.abscessus_ATCC_1997 EMITSTYSLEQINEGYQDMLDGKNIRGVIKYTEADW
MLBr_01784|M.leprae_Br4923 KFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
.::: * ::::.::.: *: :*.*: