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MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRVL VISDNGPETYLSVLACAKLGAIAVMADGNLPIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVI AVDIAAVTRESEHSLDAASLAGNADQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVT WVVGETTYSPLPATHIGGLWWILTCLMHGGLCVTGGENTTSLLEILTTNAVATTCLVPTLLSKLVSELKS ANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLSETGCTALCLPTDDGSIVKIEAGAVGRPYPG VDVYLAATDGIGPTAPGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLIDGWVNTGDLLERREDGFFYI KGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESAARALKHTIA ARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATADKARVVVRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0099 | fadD10 | - | 100% (540) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 6e-40 | 27.03% (492) | chain-fatty-acid-CoA ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 4e-37 | 28.63% (524) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0102 | fadD10 | 0.0 | 100.00% (540) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 6e-47 | 30.11% (528) | AMP-dependent synthetase and ligase |
| M. leprae Br4923 | MLBr_01994 | fadD10 | 0.0 | 74.58% (531) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_0661 | - | 0.0 | 65.86% (495) | acyl-CoA synthetase |
| M. marinum M | MMAR_0258 | fadD10 | 0.0 | 81.68% (524) | fatty-acid-CoA ligase FadD10 |
| M. avium 104 | MAV_3523 | - | 5e-40 | 26.79% (530) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_3694 | - | 1e-35 | 27.55% (519) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3186 | - | 1e-43 | 28.76% (532) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4856 | fadD10 | 0.0 | 81.87% (524) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 3e-46 | 29.73% (518) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0099|M.tuberculosis_H37Rv MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAE
Mb0102|M.bovis_AF2122/97 MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGTSALRYRELVAE
MMAR_0258|M.marinum_M --------MSDLPATVLERIIEQAQRRPEAIALRRCDGTSALPYSELAAE
MUL_4856|M.ulcerans_Agy99 --------MSDLPATVLERIIEQAQRRPEAIALRRCDGTSALPYGELVAE
MLBr_01994|M.leprae_Br4923 --------MSHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAE
MAB_0661|M.abscessus_ATCC_1997 -----------------------------------------MSYGELIGA
Mflv_0027|M.gilvum_PYR-GCK -----------MFHNLADIVRSHGRNRPDAPALIVGD--RTVSYRELDER
Mvan_0943|M.vanbaalenii_PYR-1 -----------MIHNLADIIRVHGRERPGAPALVVGD--RTVTYGELDDR
MAV_3523|M.avium_104 ------MPAAETRETLAGIVERHAQRRPDAIAIRYGE--RQWSWAEWSSR
TH_3186|M.thermoresistible__bu --MSSSTPHPNTALTWVEQVGKHARSQPDRPALRFRG--ATTTWAQLEER
MSMEG_3694|M.smegmatis_MC2_155 ------------MSLLHQLISSVAAAAPHRPAIIADDG-STIGYAEFDHQ
: :
Rv0099|M.tuberculosis_H37Rv VGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNL
Mb0102|M.bovis_AF2122/97 VGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAIAVMADGNL
MMAR_0258|M.marinum_M VDRYAGALRAQSASRGSRVLVISDNGPETYLAVLACAKLGAIAVMADGNL
MUL_4856|M.ulcerans_Agy99 VDRYAGALRAQSASRGSRVLVISDNGPETYLAVLACAKLGAIAVMADGNL
MLBr_01994|M.leprae_Br4923 VNGLAAHLSAQSVSQRSRVLVISDNGPETYLSVLACAKLGAIAVMVDGNL
MAB_0661|M.abscessus_ATCC_1997 VEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSL
Mflv_0027|M.gilvum_PYR-GCK SNRTAQAFSRTGVGPGDRVAFVERNGIEFFDVAFGSAKLGAVAVPVNWRL
Mvan_0943|M.vanbaalenii_PYR-1 SSRAAQAFAQAGVGVGDRVAFVDKNGAEFFEVTFGLAKVGAVGVPVNWRL
MAV_3523|M.avium_104 IRRAAGALRGDGIERGQCVAFLDKNHPACLEVLIGGASVGAVTTVVNWRV
TH_3186|M.thermoresistible__bu SRKLATALESRGVGHGDRVLILLTNRPEFVETLVAVNRLGAIAVPVNFRL
MSMEG_3694|M.smegmatis_MC2_155 IRAVARWIASR-TEPGDRVAVIADNSPAYAVLYYAVPLGGRVLTLINQRL
* : . * .: * . * : . : :
Rv0099|M.tuberculosis_H37Rv PIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAV---
Mb0102|M.bovis_AF2122/97 PIAAIERFCQITDPAAALVAPGSKMASSAVPEALHSIPVIAVDIAAV---
MMAR_0258|M.marinum_M PPATIDRFCQITDPVAVLIAPGSKVGSSSLPEGLAAIPAIRVDIGSG---
MUL_4856|M.ulcerans_Agy99 PPATIDRFCQITDPVAVLIAPGSKVGSSSLPEGLAAIPAIRVDIGSG---
MLBr_01994|M.leprae_Br4923 PPATISRFSEICDPSAVLVARECRIDSSSLPEILHSIPAITVNTTAD---
MAB_0661|M.abscessus_ATCC_1997 PAATVARFSEITRPAAIIPNEGGGVG------------------------
Mflv_0027|M.gilvum_PYR-GCK TAPEMRHVIADCGASVVVVGQEFTGRIEAIAD-DLDVEVVVIGKHRH--W
Mvan_0943|M.vanbaalenii_PYR-1 AAPEMRHIIADSGAKIVVVGQDFAGHLEAIED-GLDADIVVIGDHPR--W
MAV_3523|M.avium_104 IGDELVHVLADSGARVLVVGAELRPAAEAAAR-RVPSLERIIEVG-----
TH_3186|M.thermoresistible__bu VAAEVAYLAQNSGAGAVVVEQDLAPLVAGVREQRSDVACLVVGSDPDGAG
MSMEG_3694|M.smegmatis_MC2_155 SPAEQAAQLETTRPALVLGDTVYLDALPQIDSVAFGSPAWRDAVS-----
. :
Rv0099|M.tuberculosis_H37Rv TRESEHSLDAASLAGNADQGSEDP---LAMIFTSGTTGEPKAVLLANRTF
Mb0102|M.bovis_AF2122/97 TRESEHSLDAASLAGNADQGSEDP---LAMIFTSGTTGEPKAVLLANRTF
MMAR_0258|M.marinum_M TGEFAHSPDTDRPATEPGLGADDP---LAMIFTSGTTGEPKAVLLANRTF
MUL_4856|M.ulcerans_Agy99 TGEFAHSPDTDRPATEPGLGADDP---LAMIFTSGTTGEPKAVLLANRTF
MLBr_01994|M.leprae_Br4923 ATYSACSLDIDYLAGNLNYGTDDP---LAMTFTSGTTGEPKAVLLPNRTF
MAB_0661|M.abscessus_ATCC_1997 ----AENGERAYPKAQPDSGADEA---LAMIFTSGTTGEPKAVLLPNRTF
Mflv_0027|M.gilvum_PYR-GCK PTFDDLLAAAPAVDPGVVTGPDDL---VFLMYTSGTTGAPKGVMLSNANV
Mvan_0943|M.vanbaalenii_PYR-1 PAFDDWVASHPPVDPGVVTGPDDV---VLLMYTSGTTGAPKGVMLSNTNY
MAV_3523|M.avium_104 DEYESLLAAAEPAPSDAGVDTDET---ALVIYSSGTTGRPKGVLLSQRAL
TH_3186|M.thermoresistible__bu PGAELYTDAVASAAPHPGTGPDDLRTCALIMYTSGTTGRPKGAMLSYQNL
MSMEG_3694|M.smegmatis_MC2_155 ------TTAAAPEVDHAEAQPGDP---AWLLFTSGSTGVPKGVVHSHRSI
. : : ::**:** **..: .
Rv0099|M.tuberculosis_H37Rv FAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLCVT
Mb0102|M.bovis_AF2122/97 FAVPDILQKEGLNWVTWVVGETTYSPLPATHIGGLWWILTCLMHGGLCVT
MMAR_0258|M.marinum_M FAVPDILRNEGLNWVTWVDGETTYSPLPATHIGGLWWILTCLMRGGLCIT
MUL_4856|M.ulcerans_Agy99 FAVPDILRNEGLNWVTWVDGETTYSPLPATHIGGLWWILTCLMRGGLCIT
MLBr_01994|M.leprae_Br4923 FAIPDILREKGLAWIDWVVNETTYSPLSATHIGGLWWILNCLMHGGLCIT
MAB_0661|M.abscessus_ATCC_1997 FAIPDILRAEGLRWIDWVAGETTYSPLPATHIGGLWWILNGLMHGASCIT
Mflv_0027|M.gilvum_PYR-GCK VCKTAGVGG---PWKFD-ADSVSLAVMPLFHMAGFGWALAGLWEGAVTVV
Mvan_0943|M.vanbaalenii_PYR-1 VYKTGGVAG---PWQFD-ADAVSLAVMPLFHMAGSGWALAGLWQGATTVV
MAV_3523|M.avium_104 VNHAANLAP---AFPFG-DGDANLVAMPLFHVGGIGYALFGIRAGAPTIM
TH_3186|M.thermoresistible__bu LGQTLTLTR---AYNFVRNDEVVAVTSPMFHIAAIGALVPNLILGYPTVI
MSMEG_3694|M.smegmatis_MC2_155 LAAVHGTVD---GRSVT-PAGVYLLPFPMCHIAGYNMLVQHAVGATVVLM
. . . *:.. : . :
Rv0099|M.tuberculosis_H37Rv GGEN---TTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLV
Mb0102|M.bovis_AF2122/97 GGEN---TTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLV
MMAR_0258|M.marinum_M GGEN---TPSLMQILNSNAVNTTCLVPTLLSKLVSELKSAATTVPSLRLL
MUL_4856|M.ulcerans_Agy99 GGEN---TLSLMQILNSNAVNTTCLVPTLLSKLVSELKSAATTVPSLRLL
MLBr_01994|M.leprae_Br4923 GGEH---TSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPLRLI
MAB_0661|M.abscessus_ATCC_1997 GGEQ---GASLRELLVDNEVATACLVPTLLTRLVSELKLTGTDVPALRFI
Mflv_0027|M.gilvum_PYR-GCK LRD--VDPGAILDAVARHRVTNMLLVPAVIQFLLDTTGLDDTDLSRLRIV
Mvan_0943|M.vanbaalenii_PYR-1 LRD--VEPAAILDAIARHRITNMLLVPAVIQFLLDTDGVAEVDLSTLRVI
MAV_3523|M.avium_104 TRE--PDAAALIGAVRAG-ATHAFFVPPVIARFLDAGEAARASIAGLRYI
TH_3186|M.thermoresistible__bu TPTGGFDAEEFLDLLESEGVTNAFLVPTQWQALCSSPTVRDRKLR-LRTI
MSMEG_3694|M.smegmatis_MC2_155 SRFR---PESFAAQVRAHGVRSCSLAPTMLHALLAHVESTGTTLPTLEAV
: : :.*. : *. :
Rv0099|M.tuberculosis_H37Rv GYGGSRAIAADVR--FIEATGVRTAQVYGLSETGCTALCLPTDDG----S
Mb0102|M.bovis_AF2122/97 GYGGSRAIAADVR--FIEATGVRTAQVYGLSETGCTALCLPTDDG----S
MMAR_0258|M.marinum_M GYGGSRAIAADVR--FIEATGVRTAQVYGLSETGCTALCLPTDDD----S
MUL_4856|M.ulcerans_Agy99 GYGGSRAIAADVR--FIEATGVRTAQVYGLSETGCTALCLPTDDG----S
MLBr_01994|M.leprae_Br4923 VYGGSRVIAADVR--FIEAAGVRTAQFYGLSETGCTALCLPTDNG----S
MAB_0661|M.abscessus_ATCC_1997 AYGGSRAIAADVR--FIEAAGVRTAQVYGLSETGCTALCLPTDSE----S
Mflv_0027|M.gilvum_PYR-GCK VYGASPITDDVLMRGIDRF-GGIFAQVYGMTESTGSVTQLDGDEH-----
Mvan_0943|M.vanbaalenii_PYR-1 VYGASPISDDVLVRGIERF-GPIFAQVYGMTETTGSITQLDGPDH-----
MAV_3523|M.avium_104 VYGAAPMPLPLLHRALSTWPGTKFVQVYGQTELCGAVTALSDDDHRD--A
TH_3186|M.thermoresistible__bu SWGASPATPALLRAMAEVFPDAANVCTFGQTEMSPVTTVLDGADT-----
MSMEG_3694|M.smegmatis_MC2_155 AYGSAAMPLDLLRRAIEAL-GVEFHQGYGMTETGGNVTFLGPDDHRAGAA
:*.: : . :* :* * .
Rv0099|M.tuberculosis_H37Rv IVKIEAGAVGRPYPGVDVYLAAT---DGIGPTAPGAGPSASFGTLWIKSP
Mb0102|M.bovis_AF2122/97 IVKIEAGAVGRPYPGVDVYLAAT---DGIGPTAPGAGPSASFGTLWIKSP
MMAR_0258|M.marinum_M IAKIEAGAVGRPYPGVEVYLAADDEADGAGPNAPGAGPSASFGTLWIKSP
MUL_4856|M.ulcerans_Agy99 IAKIEAGAVGRPYPGVEVYLAADDEADGAGPNAPGAGPSASFGTLWIKSP
MLBr_01994|M.leprae_Br4923 ISKIEAGAVGRPYPGVEVYLADP---NGGGPTVADTASSASFGTLWIKSP
MAB_0661|M.abscessus_ATCC_1997 ISRIEQGAVGRPYPGVQTYLSPE---GGGDPTTG--AESASYGTLWIKSP
Mflv_0027|M.gilvum_PYR-GCK -LPQLLRSCGRPYPWVQIRVVDP--------TG-RDVAPGTVGEVWTRSD
Mvan_0943|M.vanbaalenii_PYR-1 -VPALLRSCGRPYPWVQIRIVDE--------TG-ADAVAGTVGEVWTRSE
MAV_3523|M.avium_104 ARPQLQLSAGKAVQGCEIRIVDP--------NNCAELPAGRSGEVWVRSN
TH_3186|M.thermoresistible__bu --IEKLGSVGRPVPLVDARIVDA--------DM-NDVPQGEVGEIVYRGP
MSMEG_3694|M.smegmatis_MC2_155 GHPEVLVSAGHPHSGVEIGIVDA--------DG-APLPPGGIGEIVVRGA
: *:. : : . * : :.
Rv0099|M.tuberculosis_H37Rv ANMLGYWNNPE-RTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICG
Mb0102|M.bovis_AF2122/97 ANMLGYWNNPE-RTAEVLIDGWVNTGDLLERREDGFFYIKGRSSEMIICG
MMAR_0258|M.marinum_M ANMLGYWSNPQ-RTQEVLIDGWVNTGDLLERHEDGFFYIKGRSSEMIISG
MUL_4856|M.ulcerans_Agy99 ANMLGYWSNPQ-RTQEVLIDGWVNTGDLLERHEDGFFYIKGRSSEMIISG
MLBr_01994|M.leprae_Br4923 ANMLGYWNNPE-RTREILVDGWVNTGDLVERREDGFFYIKGRSSEMIVSG
MAB_0661|M.abscessus_ATCC_1997 ANMLGYWGSPE-RTGEVLAEGWVNTGDLVERRADGFFYIRGRSSEMIISG
Mflv_0027|M.gilvum_PYR-GCK QNMLGYWNNPEATAATLTPDGWLRTGDAGYLDRDGYLYLHDRIKDMIVSG
Mvan_0943|M.vanbaalenii_PYR-1 QNMLGYWNNPDATASTLTADGWLKTGDAGYVDDDGYLFLHDRIKDMIVSG
MAV_3523|M.avium_104 QNMSGYLNRAEATAETITADGWVRTGDVGRLDADGYVYIEDRLKDMIITG
TH_3186|M.thermoresistible__bu QTMLGYWDNPEETAKAFRG-GWFHSGDLVRADEDGYLYVVDRLKDMIISG
MSMEG_3694|M.smegmatis_MC2_155 QVARGYWPD-----RPSTVDGWLHTGDIGRLDHTGRLFVVDRLKDIIVTG
** **..:** * .:: .* .::*: *
Rv0099|M.tuberculosis_H37Rv GVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESA
Mb0102|M.bovis_AF2122/97 GVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGALVGLAVVASAELDESA
MMAR_0258|M.marinum_M GVNIAPDEVDRIAEGVPGVREAACFEIPDPEFGALVGLAVVAATDMDASA
MUL_4856|M.ulcerans_Agy99 GVNIAPDEVDRIAEGVPGVREAACFEIPDPEFGALVGLAVVAATDVDASA
MLBr_01994|M.leprae_Br4923 GVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNEST
MAB_0661|M.abscessus_ATCC_1997 GVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVGLAVVATTELDGAG
Mflv_0027|M.gilvum_PYR-GCK AENVYPAEVENVLMTHPAVTDVAVIGIPDTRWGEAVKAVVVAG---APVT
Mvan_0943|M.vanbaalenii_PYR-1 GENVYPVEVENVLMTHPAVADAAVIGVPDRRWGEAVKAVVVAAR-GAQLT
MAV_3523|M.avium_104 GENVYGPEVESVLIEHPAVVDAAVIGVPDDFWGESVKAIVVAD---GDVD
TH_3186|M.thermoresistible__bu GENVYCTEVEAAIAEHLKVREVAVVGAPHPKWGETPVAVVVPRDPDDPPG
MSMEG_3694|M.smegmatis_MC2_155 GENVSSREVEDVLSGHPDVDMVAVVGVPDGYWGEAVCAVVVPVP-GRNPR
. *: **: * .* *. :* *:.
Rv0099|M.tuberculosis_H37Rv ARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATA
Mb0102|M.bovis_AF2122/97 ARALKHTIAARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASLAAAATA
MMAR_0258|M.marinum_M ARKLKHTIAAHYRRESESVARPSTIVIVSEIPRTQSGKVMRTSLAAAAN-
MUL_4856|M.ulcerans_Agy99 ARKLKHTIAAHYRRESESVARPSTIVIVSEIPRTQSGKVMRTSLATAAN-
MLBr_01994|M.leprae_Br4923 AIELKRRIAARYRRESESMARPSKIVIVADIPRTQSGKVIRATLAAALNG
MAB_0661|M.abscessus_ATCC_1997 TAALKQRIAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNG
Mflv_0027|M.gilvum_PYR-GCK E----AELIAFAREQLAGFKLPKSVDFVDALPRNPSGKLLKRQLREPYWT
Mvan_0943|M.vanbaalenii_PYR-1 E----AELIAFARDRIGGFKLPKSVDFVDVLPRNPSGKLLKRALREPYWD
MAV_3523|M.avium_104 A----ADVIEFCRRHLAGFKCPRTVDFVAELPRNASGKILKTQLREPFWR
TH_3186|M.thermoresistible__bu S----DELIEFTSTRLASYKKPTRVVVVDALPRNASGKVLKAPLRDAVRD
MSMEG_3694|M.smegmatis_MC2_155 A----DDLIDHVRSAIAAFKRPREVLFVDELPLTGNGKIAKDRVRDIART
: * : .* :* . .**: : :
Rv0099|M.tuberculosis_H37Rv DKARVVVRG
Mb0102|M.bovis_AF2122/97 DKARVVVRG
MMAR_0258|M.marinum_M ---QVQTGG
MUL_4856|M.ulcerans_Agy99 ---QVQTGG
MLBr_01994|M.leprae_Br4923 EQLGMVVRD
MAB_0661|M.abscessus_ATCC_1997 ARARV----
Mflv_0027|M.gilvum_PYR-GCK DEDRHIG--
Mvan_0943|M.vanbaalenii_PYR-1 GADRHIG--
MAV_3523|M.avium_104 DRDRRV---
TH_3186|M.thermoresistible__bu DS-------
MSMEG_3694|M.smegmatis_MC2_155 ALTA-----