For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_3186 | - | - | 100% (524) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_2878 | - | e-147 | 54.64% (507) | PUTATIVE AMP-binding enzyme, putative |
| M. thermoresistible (build 8) | TH_2591 | - | 3e-84 | 39.80% (505) | PUTATIVE feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 1e-146 | 52.70% (518) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0714 | - | 1e-149 | 53.33% (525) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 1e-146 | 52.90% (518) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02661 | - | 7e-48 | 33.12% (477) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 1e-156 | 55.36% (513) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0409 | fadD5 | 1e-144 | 52.76% (508) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_5018 | - | 1e-150 | 54.07% (516) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0131 | - | 1e-150 | 55.49% (510) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 6e-63 | 34.65% (505) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0131 | - | 1e-153 | 53.93% (521) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0172|M.bovis_AF2122/97 -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
Rv0166|M.tuberculosis_H37Rv -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
MMAR_0409|M.marinum_M -------------------MTAELASHLPQAA-HALEQPYLARRQNWVNQ
MAV_5018|M.avium_104 --------------------MLSLTAQLAHHPTQANEQPYLSRRQNWVNQ
Mflv_0714|M.gilvum_PYR-GCK MTRTTSCLIKCHTSANPSTMERKTLTDPTGLSGSATEQPNLARRRNWANQ
Mvan_0131|M.vanbaalenii_PYR-1 -------MFDQISSFRNPSMEQKTLTEAIQQPGFATEQPYLARRQNWTNQ
MSMEG_0131|M.smegmatis_MC2_155 -----------------------MTAEPSQ-----IEQPYLARRQNWVNQ
MAB_4569c|M.abscessus_ATCC_199 -------------------MTDTIDATVQSAG---LAQPYRARRQNWCNQ
TH_3186|M.thermoresistible__bu ---------------------------------MSSSTPHPNTALTWVEQ
MUL_0650|M.ulcerans_Agy99 -----------------------------------MSDDLLRNPTHNGHL
MLBr_02661|M.leprae_Br4923 ------------------MKSESITSSRAPVEQIDARLTGQFESPSIASL
Mb0172|M.bovis_AF2122/97 LERHAMMQPDAPALRFVG--NTMTWADLRRRVAALAGALSGRGVGFGDRV
Rv0166|M.tuberculosis_H37Rv LERHAMMQPDAPALRFVG--NTMTWADLRRRVAALAGALSGRGVGFGDRV
MMAR_0409|M.marinum_M LERHAMMQPRATAIRYLG--HTVTWADLRYRVAALAGSLSRRGVGFGDRV
MAV_5018|M.avium_104 LERHALMQPNATALRFLG--KGLTWGELHGRVRALADALSRRGVGFGDRV
Mflv_0714|M.gilvum_PYR-GCK LSRHALMQPDTVALRFLG--RSTTWGELDRRVTALAGALHERGVGFGDRV
Mvan_0131|M.vanbaalenii_PYR-1 LARHALMQPDQPALRFLG--NTTTWGELDRRVSALAGALHKRGVGFGDRV
MSMEG_0131|M.smegmatis_MC2_155 LTRHAMMQPDKTALRFLG--RTTTWRELDDRVTRLAGALNRRGVGFGDRV
MAB_4569c|M.abscessus_ATCC_199 LARHALMQPDATAIRYLG--HSISWAELHQRVQALADALSRRGVGFGDRV
TH_3186|M.thermoresistible__bu VGKHARSQPDRPALRFRG--ATTTWAQLEERSRKLATALESRGVGHGDRV
MUL_0650|M.ulcerans_Agy99 LVGALERHKNRPVLFLGD--TTLTGGQLAERISQYIQAFEALGAGTGVTV
MLBr_02661|M.leprae_Br4923 VEAAAIRNPSAPALVVTDNRIVVSYRDLLRLVDDLTVQLALGGLLPGDRV
: : .: . : :* : * * *
Mb0172|M.bovis_AF2122/97 MILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLT
Rv0166|M.tuberculosis_H37Rv MILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLT
MMAR_0409|M.marinum_M MILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVIT
MAV_5018|M.avium_104 MVLMLNRPEFMESVLAINMLGAIAVPLNFRLTAAEIAFLVQDCQARVVIT
Mflv_0714|M.gilvum_PYR-GCK LILMLNRTEFMESVLAVNKLGGIAVPVNFRMTPSEIAFLVSDCAAEVVIT
Mvan_0131|M.vanbaalenii_PYR-1 LILMLNRTEFIEAVLATNKLGAIAVPVNFRMTPAEIAFLVSDCEAKAIIT
MSMEG_0131|M.smegmatis_MC2_155 LILMLNRTEFVEAMLAANRLGAIAVPVNFRMTPPEIAYLVSDCEAHVVVT
MAB_4569c|M.abscessus_ATCC_199 LILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAIT
TH_3186|M.thermoresistible__bu LILLTNRPEFVETLVAVNRLGAIAVPVNFRLVAAEVAYLAQNSGAGAVVV
MUL_0650|M.ulcerans_Agy99 GLLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALII
MLBr_02661|M.leprae_Br4923 ALCAASNIEFVVGLLAASRAGLIVVPLDPALPVNEQCIRSQAAGVRVTLV
: .. * : * . * .:. : . . :
Mb0172|M.bovis_AF2122/97 EA--ALAPVAIGVRNIQPLLSVIVVAG----GSSQDSVFGYEDLLNEAGD
Rv0166|M.tuberculosis_H37Rv EA--ALAPVAIGVRNIQPLLSVIVVAG----GSSQDSVFGYEDLLNEAGD
MMAR_0409|M.marinum_M EE--VLAQVAVGVREIAPALSTIVVAG----GASDPTVVGYDELISETGD
MAV_5018|M.avium_104 EA--VLAPVATGVRDIESLLDTVVVAG----GSSDDAVLGYDDLIDETGA
Mflv_0714|M.gilvum_PYR-GCK ES--VLENVATAVRDIDPKLATVIVAG----GTSRDNVLDYDDVLASTTA
Mvan_0131|M.vanbaalenii_PYR-1 EA--VLANVATAVRDIDPTLATVISAG----GSG-DDVLDYDDVLAENAP
MSMEG_0131|M.smegmatis_MC2_155 EP--VLAGVATAVRDLDATLQTVIVAG----GATEDGVLGYDDLIAEEGE
MAB_4569c|M.abscessus_ATCC_199 ET--VLAPVAAAVRQQAPALETVIVAG----SASENGVLGYEEVIAEPGE
TH_3186|M.thermoresistible__bu EQ--DLAPLVAGVREQRSDVACLVVGSDP--DGAGPGAELYTDAVASAAP
MUL_0650|M.ulcerans_Agy99 DPNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQPK
MLBr_02661|M.leprae_Br4923 DS-LALEGVSDQRAATMRYWPIAVSYG-SVTGASEGSLLVHLDDTAALHP
: : : . :
Mb0172|M.bovis_AF2122/97 VHEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANI
Rv0166|M.tuberculosis_H37Rv VHEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANI
MMAR_0409|M.marinum_M PPEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANI
MAV_5018|M.avium_104 AHQPVDIPNDAAALIMYTSGTTGRPKGAVLTHTNLTGQTMTGLYTNGADI
Mflv_0714|M.gilvum_PYR-GCK APPLVDIPDDSPALIMYTSGTTGRPKGAVLTHNNLAGQAMTLLFTNGADI
Mvan_0131|M.vanbaalenii_PYR-1 CP-VVDIPNDAPALIMYTSGTTGRPKGAVLTHTNLTGQVMTLLFTNGADI
MSMEG_0131|M.smegmatis_MC2_155 PPAPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLSAQAMMHLFTTGADL
MAB_4569c|M.abscessus_ATCC_199 PHAEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDL
TH_3186|M.thermoresistible__bu HPGTGPDDLRTCALIMYTSGTTGRPKGAMLSYQNLLGQTLTLTRAYNFVR
MUL_0650|M.ulcerans_Agy99 PLVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNIT--AMTSIQLAEWEW
MLBr_02661|M.leprae_Br4923 VTSTPDGLRHDDAMIMFTGGTTGLPKMVPWTDGNIAGSVHAIITAYQLG-
. : :*.**** ** . : *: .
Mb0172|M.bovis_AF2122/97 NSDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEA
Rv0166|M.tuberculosis_H37Rv NSDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEA
MMAR_0409|M.marinum_M NSDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEA
MAV_5018|M.avium_104 NNDVGFIGVPFFHIAGIG-NMLTGLLLGIPTVIYPLGAFEPGQLLDVLAA
Mflv_0714|M.gilvum_PYR-GCK NHDIGFIGVPFFHIAGVG-SIVSGMMLGRPTVIYPLGAFDPNELLDVLEA
Mvan_0131|M.vanbaalenii_PYR-1 NHDIGFIGVPFFHIAGVG-SSVSGLLLGRPTVLYPVGAFDPNELLDVLEA
MSMEG_0131|M.smegmatis_MC2_155 NSDVGFVGVPLFHIAGVAGSVLSGVTLGVPTVLYPLGAFDPDGLLDVLES
MAB_4569c|M.abscessus_ATCC_199 NSDVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLES
TH_3186|M.thermoresistible__bu NDEVVAVTSPMFHIAAIG-ALVPNLILGYPTVITPTGGFDAEEFLDLLES
MUL_0650|M.ulcerans_Agy99 PEHPRFLMCTPLSHAGAA---FFTPTLVKGGEMIVLAKFDPGEVLRVIEE
MLBr_02661|M.leprae_Br4923 PQDATVVVMPLYHGHGLIAALLSTLASGGVVLLPARARFSARTFWDDIDA
. : . . . : . *.. . :
Mb0172|M.bovis_AF2122/97 EKVTGIFLVPAQWQAVCTEQQARPRDLR---LRVLSWGAAPAPDALLRQM
Rv0166|M.tuberculosis_H37Rv EKVTGIFLVPAQWQAVCTEQQARPRDLR---LRVLSWGAAPAPDALLRQM
MMAR_0409|M.marinum_M ERVSGIFLVPAQWQAVCAEQQARPRELS---LRVMSWGAAPAPDALLRQM
MAV_5018|M.avium_104 EKVTGIFLVPAQWQAVCAEQRARPRDLK---LRVISWGAAPAPDALLREM
Mflv_0714|M.gilvum_PYR-GCK EKVTGIFLVPAQWQAVCAAQKANPRNLK---LRFLSWGAAPASDTLLRQM
Mvan_0131|M.vanbaalenii_PYR-1 EKVTGIFLVPAQWQAVCAAQKARPRDLK---LRFLSWGAAPASDTLLREM
MSMEG_0131|M.smegmatis_MC2_155 EQVTGIFLVPAQWQAVCAAQRARPRNLK---LRALSWGAAPASDTLLREM
MAB_4569c|M.abscessus_ATCC_199 EGVTGIFLVPAQWQAVCAAQQANPRKVR---LKTLSWGAAPATDVLLRTM
TH_3186|M.thermoresistible__bu EGVTNAFLVPTQWQALCSSPTVRDRKLR---LRTISWGASPATPALLRAM
MUL_0650|M.ulcerans_Agy99 QRITATMLVPSMLYALMDHPDPHTRDLSS--LETVYYGASAINPVRLAEA
MLBr_02661|M.leprae_Br4923 VAATWYTAAPAIHRILLELASTQSFRSKRAKLRFIRSCSAPLTQETAQAL
: .*: : . *. : ::.
Mb0172|M.bovis_AF2122/97 SATFPETQILAA---FGQTEMSPVTCMLLGEDAIAK-RGSVGRVIPTVAA
Rv0166|M.tuberculosis_H37Rv SATFPETQILAA---FGQTEMSPVTCMLLGEDAIAK-RGSVGRVIPTVAA
MMAR_0409|M.marinum_M SEVFPGTQIMAA---FGQTEMSPVTCMLLGEDAIRK-RGSVGKVIPTVSA
MAV_5018|M.avium_104 SAMFPGTQILAA---FGQTEMSPVTCMLLGEDAIRK-RGSVGKVIPTVAA
Mflv_0714|M.gilvum_PYR-GCK SETFPGAQILAA---FGQTEMSPVTCMLLGDDALRK-LGSVGKVIPTVSA
Mvan_0131|M.vanbaalenii_PYR-1 AETFPGAQILAA---FGQTEMSPVTCMLLGDDAIRK-LGSVGKVIPTVSA
MSMEG_0131|M.smegmatis_MC2_155 NEVFPDAQIFAA---FGQTEMSPVTCMLLGDDAIRK-LGSVGRVIPTVSA
MAB_4569c|M.abscessus_ATCC_199 SETFPDARILAA---FGQTEMSPVTCMLMGDDAIRK-MGSVGRVIPTVSA
TH_3186|M.thermoresistible__bu AEVFPDAANVCT---FGQTEMSPVTTVLDGADTIEK-LGSVGRPVPLVDA
MUL_0650|M.ulcerans_Agy99 IDRFG-PIFAQY---YGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARV
MLBr_02661|M.leprae_Br4923 REEFLAPVICAFGMTEATHQVTTTNIKWFGQGENPTVTNGLVGQSTGVQI
* . . : . . . . . .
Mb0172|M.bovis_AF2122/97 RVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDL
Rv0166|M.tuberculosis_H37Rv RVVDQNMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDL
MMAR_0409|M.marinum_M RVVDDEMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGGWFHSGDL
MAV_5018|M.avium_104 RVVDENMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGGWFHSGDL
Mflv_0714|M.gilvum_PYR-GCK RIVDEDMNDVPIGQVGEIVYRAPTLMTGYWNNPTATAEAFAGGWFHSGDL
Mvan_0131|M.vanbaalenii_PYR-1 RIVDEDMNDVPVGQVGEIVYRAPTLMAGYWNNPKATAEAFAGGWFHSGDL
MSMEG_0131|M.smegmatis_MC2_155 RVVDDNMNDVPVGEVGEIVYRGPNLMVGYWNNPKATAEAFAGGWFHSGDL
MAB_4569c|M.abscessus_ATCC_199 RVVDDNMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGGWFHSGDL
TH_3186|M.thermoresistible__bu RIVDADMNDVPQGEVGEIVYRGPQTMLGYWDNPEETAKAFRGGWFHSGDL
MUL_0650|M.ulcerans_Agy99 ALLGEDGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDM
MLBr_02661|M.leprae_Br4923 RIVGSDGQPLPPDTVGEVWLRGSTVVRGYLGDPAITAANFTHGWLRTGDL
::. : : :* . **: .. * ..* ** * **:::**:
Mb0172|M.bovis_AF2122/97 VRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRA
Rv0166|M.tuberculosis_H37Rv VRMDSDGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRA
MMAR_0409|M.marinum_M VRMDEDGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRA
MAV_5018|M.avium_104 VRMDEDGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRA
Mflv_0714|M.gilvum_PYR-GCK VRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRS
Mvan_0131|M.vanbaalenii_PYR-1 VRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPEIVEVAVIGRA
MSMEG_0131|M.smegmatis_MC2_155 VRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLAAHPAIMEVAVIGRP
MAB_4569c|M.abscessus_ATCC_199 VRQDEDGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRP
TH_3186|M.thermoresistible__bu VRADEDGYLYVVDRLKDMIISGGENVYCTEVEAAIAEHLKVREVAVVGAP
MUL_0650|M.ulcerans_Agy99 AREDEDGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAP
MLBr_02661|M.leprae_Br4923 GSLSVTGDLRIRGRIKELINRSGEKISPERVEGVLASHHNVMEVAVFGDP
. * : .* *::* .* :: .:* .:* * : :*.*.* .
Mb0172|M.bovis_AF2122/97 DEKWGEVPIAVAAVTN--------DDLRIEDLGEFLTDRLARYKHPKALE
Rv0166|M.tuberculosis_H37Rv DEKWGEVPIAVAAVTN--------DDLRIEDLGEFLTDRLARYKHPKALE
MMAR_0409|M.marinum_M DEKWGEVPIAVAAVTK--------DHLRIEDLDEYLTERLARYKHPKALE
MAV_5018|M.avium_104 HEKWGEVPIAVAAVAN--------DNLALEDLDEFLTERLARYKHPKALE
Mflv_0714|M.gilvum_PYR-GCK HRKWGEVPVAVAVLRSSLN-STGSGRLELTDLEQFLGDRLARYKHPKAIE
Mvan_0131|M.vanbaalenii_PYR-1 HEKWGEVPVAVAVVRSSLE-ATPGAGIELADLEQFLTERLARYKHPKALE
MSMEG_0131|M.smegmatis_MC2_155 HEKWGEVPVAVVALNSATA-ES----ISLGELDSFLTERLARYKHPKALE
MAB_4569c|M.abscessus_ATCC_199 HEKWGEVPVAVAAIHG--------AALTLAELDGFLTARLARYKHPKDLV
TH_3186|M.thermoresistible__bu HPKWGETPVAVVVPRDP------DDPPGSDELIEFTSTRLASYKKPTRVV
MUL_0650|M.ulcerans_Agy99 DEKWGEAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVV
MLBr_02661|M.leprae_Br4923 DKVYGETVTAVIVPREV-------IAPTPSELAVFCRDRLAAFEVPTRFQ
. :**. ** . :: * . : *. .
Mb0172|M.bovis_AF2122/97 IVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv IVDALPRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M IVDALPRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAV_5018|M.avium_104 IVDALPRNPAGKVLKTELRIRYGGG----------------------
Mflv_0714|M.gilvum_PYR-GCK IVEALPRNPAGKVLKTELRVRFGSEESVDAGESATAATSSAAAPKD-
Mvan_0131|M.vanbaalenii_PYR-1 IVDALPRNPAGKVLKTELRIRYSAASFADAGESSTPPTISTAPQRN-
MSMEG_0131|M.smegmatis_MC2_155 VVDALPRNPSGKVLKTELRERFGRATSLDGGESNSATTVSAG-----
MAB_4569c|M.abscessus_ATCC_199 IVDALPRNPSGKVLKTELRQRFGIAD---------------------
TH_3186|M.thermoresistible__bu VVDALPRNASGKVLKAPLRDAVRDDS---------------------
MUL_0650|M.ulcerans_Agy99 VVDSLPLTGLGKPDKKAVRARFWEGAGRAVG----------------
MLBr_02661|M.leprae_Br4923 EASALPHTAKGSLDRRAVAEQFAHRG---------------------
..:** . *. : :