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MSHLPPTVLERILKQAHERPEAIALRRSDGTSELRYGQLVAEVNGLAAHLSAQSVSQRSRVLVISDNGPE TYLSVLACAKLGAIAVMVDGNLPPATISRFSEICDPSAVLVARECRIDSSSLPEILHSIPAITVNTTADA TYSACSLDIDYLAGNLNYGTDDPLAMTFTSGTTGEPKAVLLPNRTFFAIPDILREKGLAWIDWVVNETTY SPLSATHIGGLWWILNCLMHGGLCITGGEHTSSLTEVLNANKVATTCLVPTLLSKLVYELKFGDVVTPPL RLIVYGGSRVIAADVRFIEAAGVRTAQFYGLSETGCTALCLPTDNGSISKIEAGAVGRPYPGVEVYLADP NGGGPTVADTASSASFGTLWIKSPANMLGYWNNPERTREILVDGWVNTGDLVERREDGFFYIKGRSSEMI VSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGALVGLAVIPSAELNESTAIELKRRIAARYRRESE SMARPSKIVIVADIPRTQSGKVIRATLAAALNGEQLGMVVRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_01994 | fadD10 | - | 100% (532) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_00134 | fadD22 | 4e-25 | 25.61% (492) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 2e-24 | 30.58% (363) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0102 | fadD10 | 0.0 | 74.58% (531) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 1e-46 | 28.57% (518) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0099 | fadD10 | 0.0 | 74.58% (531) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_0661 | - | 0.0 | 66.53% (490) | acyl-CoA synthetase |
| M. marinum M | MMAR_0258 | fadD10 | 0.0 | 71.70% (530) | fatty-acid-CoA ligase FadD10 |
| M. avium 104 | MAV_1899 | - | 2e-34 | 26.90% (487) | feruloyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_1098 | - | 2e-31 | 27.07% (351) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3186 | - | 1e-40 | 28.33% (533) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4856 | fadD10 | 0.0 | 72.08% (530) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 5e-44 | 28.35% (522) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0027|M.gilvum_PYR-GCK -----------MFHNLADIVRSHGRN----------RPDAPALIVGDRTV
Mvan_0943|M.vanbaalenii_PYR-1 -----------MIHNLADIIRVHGRE----------RPGAPALVVGDRTV
MSMEG_1098|M.smegmatis_MC2_155 --------MTQVKSSSPDLLRHPTHSGHLTVAALKRNRDKPVLFLGDTTL
MAV_1899|M.avium_104 -------------MLIGDIATNNARR----------YPQKRALVDADRVH
TH_3186|M.thermoresistible__bu --MSSSTPHPNTALTWVEQVGKHARS----------QPDRPALRFRGATT
Mb0102|M.bovis_AF2122/97 MGGKKFQAMPQLPSTVLDRVFEQARQ--------QPEAIALRRCDGTSAL
Rv0099|M.tuberculosis_H37Rv MGGKKFQAMPQLPSTVLDRVFEQARQ--------QPEAIALRRCDGTSAL
MMAR_0258|M.marinum_M --------MSDLPATVLERIIEQAQR--------RPEAIALRRCDGTSAL
MUL_4856|M.ulcerans_Agy99 --------MSDLPATVLERIIEQAQR--------RPEAIALRRCDGTSAL
MLBr_01994|M.leprae_Br4923 --------MSHLPPTVLERILKQAHE--------RPEAIALRRSDGTSEL
MAB_0661|M.abscessus_ATCC_1997 -------------------------------------------------M
Mflv_0027|M.gilvum_PYR-GCK SYRELDERSNRTAQAFSRTGVGPGDRVAFVERNGIEFFDVAFGSAKLGAV
Mvan_0943|M.vanbaalenii_PYR-1 TYGELDDRSSRAAQAFAQAGVGVGDRVAFVDKNGAEFFEVTFGLAKVGAV
MSMEG_1098|M.smegmatis_MC2_155 TGGELADRISQYIQAFEALGAGSGEGVGLLSLNRPEVLMIIGAGQTQGYR
MAV_1899|M.avium_104 TWTQVDERARRLAGYLAGRGLEPGERVMVIARNCIEWPEISFGLAKAGLI
TH_3186|M.thermoresistible__bu TWAQLEERSRKLATALESRGVGHGDRVLILLTNRPEFVETLVAVNRLGAI
Mb0102|M.bovis_AF2122/97 RYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAI
Rv0099|M.tuberculosis_H37Rv RYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKLGAI
MMAR_0258|M.marinum_M PYSELAAEVDRYAGALRAQSASRGSRVLVISDNGPETYLAVLACAKLGAI
MUL_4856|M.ulcerans_Agy99 PYGELVAEVDRYAGALRAQSASRGSRVLVISDNGPETYLAVLACAKLGAI
MLBr_01994|M.leprae_Br4923 RYGQLVAEVNGLAAHLSAQSVSQRSRVLVISDNGPETYLSVLACAKLGAI
MAB_0661|M.abscessus_ATCC_1997 SYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAI
:: : . . * .: * : . *
Mflv_0027|M.gilvum_PYR-GCK AVPVN---------WRLTAPEMRHVIADCGASVVVVGQEFTGRIEAIADD
Mvan_0943|M.vanbaalenii_PYR-1 GVPVN---------WRLAAPEMRHIIADSGAKIVVVGQDFAGHLEAIEDG
MSMEG_1098|M.smegmatis_MC2_155 RTALHPLGSLDDHAYVLSDAEVTTLIIDPTPAFVERALGLLEKVPTLRQI
MAV_1899|M.avium_104 AVPVN---------IRLAPDEVAHVRDDCGARGVIVHADHLDKFSSEIDR
TH_3186|M.thermoresistible__bu AVPVN---------FRLVAAEVAYLAQNSGAGAVVVEQDLAPLVAGVREQ
Mb0102|M.bovis_AF2122/97 AVMADG---------NLPIAAIERFCQITDPAAALVAPGSKMASSAVPEA
Rv0099|M.tuberculosis_H37Rv AVMADG---------NLPIAAIERFCQITDPAAALVAPGSKMASSAVPEA
MMAR_0258|M.marinum_M AVMADG---------NLPPATIDRFCQITDPVAVLIAPGSKVGSSSLPEG
MUL_4856|M.ulcerans_Agy99 AVMADG---------NLPPATIDRFCQITDPVAVLIAPGSKVGSSSLPEG
MLBr_01994|M.leprae_Br4923 AVMVDG---------NLPPATISRFSEICDPSAVLVARECRIDSSSLPEI
MAB_0661|M.abscessus_ATCC_1997 AVMVDD---------SLPAATVARFSEITRPAAIIPNEGGGVG-------
. . * : . .
Mflv_0027|M.gilvum_PYR-GCK ---LDVEVVVIGKHRHWPTFDDLLAAAPAVDPGVVTGP---DDLVFLMYT
Mvan_0943|M.vanbaalenii_PYR-1 ---LDADIVVIGDHPRWPAFDDWVASHPPVDPGVVTGP---DDVVLLMYT
MSMEG_1098|M.smegmatis_MC2_155 ---LTIGPVPEALAGVATDLNAEAAKYPAKPLVAAELPP--DHIGGLTYT
MAV_1899|M.avium_104 ---LDVVLPIG------DEYESALAAAEPVAPQVAISP---DDVAVILYT
TH_3186|M.thermoresistible__bu RSDVACLVVGSDPDGAGPGAELYTDAVASAAPHPGTGPDDLRTCALIMYT
Mb0102|M.bovis_AF2122/97 LHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDP------LAMIFT
Rv0099|M.tuberculosis_H37Rv LHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDP------LAMIFT
MMAR_0258|M.marinum_M LAAIPAIRVDIGSGTGEFAHSPDTDRPATEPGLGADDP------LAMIFT
MUL_4856|M.ulcerans_Agy99 LAAIPAIRVDIGSGTGEFAHSPDTDRPATEPGLGADDP------LAMIFT
MLBr_01994|M.leprae_Br4923 LHSIPAITVNTTADATYSACSLDIDYLAGNLNYGTDDP------LAMTFT
MAB_0661|M.abscessus_ATCC_1997 ------------------AENGERAYPKAQPDSGADEA------LAMIFT
. . : :*
Mflv_0027|M.gilvum_PYR-GCK SGTTGAPKGVMLSNANVVCKTAGVGG---PWKFDADS-VSLAVMPLFHMA
Mvan_0943|M.vanbaalenii_PYR-1 SGTTGAPKGVMLSNTNYVYKTGGVAG---PWQFDADA-VSLAVMPLFHMA
MSMEG_1098|M.smegmatis_MC2_155 GGTTGKPKGVMGTVRSITTMTTIQLA---EWEWPENP-RFLMCTPLSHAG
MAV_1899|M.avium_104 SGTTGRAKGVMHTHRGLLYQAADTNL---VTEANRSD-VMLATTPFFTAG
TH_3186|M.thermoresistible__bu SGTTGRPKGAMLSYQNLLGQTLTLTR---AYNFVRNDEVVAVTSPMFHIA
Mb0102|M.bovis_AF2122/97 SGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIG
Rv0099|M.tuberculosis_H37Rv SGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPATHIG
MMAR_0258|M.marinum_M SGTTGEPKAVLLANRTFFAVPDILRNEGLNWVTWVDGETTYSPLPATHIG
MUL_4856|M.ulcerans_Agy99 SGTTGEPKAVLLANRTFFAVPDILRNEGLNWVTWVDGETTYSPLPATHIG
MLBr_01994|M.leprae_Br4923 SGTTGEPKAVLLPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSATHIG
MAB_0661|M.abscessus_ATCC_1997 SGTTGEPKAVLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPATHIG
.**** .*..: . . . .
Mflv_0027|M.gilvum_PYR-GCK GFGWALAGLWEGAVTVVLRD--VDPGAILDAVARHRVTNMLLVPAVIQFL
Mvan_0943|M.vanbaalenii_PYR-1 GSGWALAGLWQGATTVVLRD--VEPAAILDAIARHRITNMLLVPAVIQFL
MSMEG_1098|M.smegmatis_MC2_155 -AAFFVPTIVKGGEMIVLPK--FDPGEVLRVIEERRITATMLVPSMLYAL
MAV_1899|M.avium_104 GMVRTVSWLYLGQTMVIHQR--FDPQAVIDEIERSSITFTTFIPTMLHRT
TH_3186|M.thermoresistible__bu AIGALVPNLILGYPTVITPTGGFDAEEFLDLLESEGVTNAFLVPTQWQAL
Mb0102|M.bovis_AF2122/97 GLWWILTCLMHGGLCVTGGE---NTTSLLEILTTNAVATTCLVPTLLSKL
Rv0099|M.tuberculosis_H37Rv GLWWILTCLMHGGLCVTGGE---NTTSLLEILTTNAVATTCLVPTLLSKL
MMAR_0258|M.marinum_M GLWWILTCLMRGGLCITGGE---NTPSLMQILNSNAVNTTCLVPTLLSKL
MUL_4856|M.ulcerans_Agy99 GLWWILTCLMRGGLCITGGE---NTLSLMQILNSNAVNTTCLVPTLLSKL
MLBr_01994|M.leprae_Br4923 GLWWILNCLMHGGLCITGGE---HTSSLTEVLNANKVATTCLVPTLLSKL
MAB_0661|M.abscessus_ATCC_1997 GLWWILNGLMHGASCITGGE---QGASLRELLVDNEVATACLVPTLLTRL
: : * : . . : : ::*:
Mflv_0027|M.gilvum_PYR-GCK LDTTG-LDDTDLSRLRIVVYGASPITDDVLMRGIDRFG-GIFAQVYGMTE
Mvan_0943|M.vanbaalenii_PYR-1 LDTDG-VAEVDLSTLRVIVYGASPISDDVLVRGIERFG-PIFAQVYGMTE
MSMEG_1098|M.smegmatis_MC2_155 LDHPD-SHTRDLSSLETVYYGASAMNPVRLAEALKRFG-PIFAQYYGQSE
MAV_1899|M.avium_104 LAILEDGPPRDMSSLRRISYGSAPVPPGLARKAMDLLG-CDLQQRYGLTE
TH_3186|M.thermoresistible__bu CSSPTVRDRK--LRLRTISWGASPATPALLRAMAEVFPDAANVCTFGQTE
Mb0102|M.bovis_AF2122/97 VSELK-SANATVPSLRLVGYGGSRAIAADVR-FIEATG-VRTAQVYGLSE
Rv0099|M.tuberculosis_H37Rv VSELK-SANATVPSLRLVGYGGSRAIAADVR-FIEATG-VRTAQVYGLSE
MMAR_0258|M.marinum_M VSELK-SAATTVPSLRLLGYGGSRAIAADVR-FIEATG-VRTAQVYGLSE
MUL_4856|M.ulcerans_Agy99 VSELK-SAATTVPSLRLLGYGGSRAIAADVR-FIEATG-VRTAQVYGLSE
MLBr_01994|M.leprae_Br4923 VYELK-FGDVVTPPLRLIVYGGSRVIAADVR-FIEAAG-VRTAQFYGLSE
MAB_0661|M.abscessus_ATCC_1997 VSELK-LTGTDVPALRFIAYGGSRAIAADVR-FIEAAG-VRTAQVYGLSE
*. : :*.: . :* :*
Mflv_0027|M.gilvum_PYR-GCK STGSVTQLDGDEHL------PQLLRSCGRPYPWVQIRVVDP---------
Mvan_0943|M.vanbaalenii_PYR-1 TTGSITQLDGPDHV------PALLRSCGRPYPWVQIRIVDE---------
MSMEG_1098|M.smegmatis_MC2_155 APMVISYLGKKDHD------EKRLTSCGRPTMFARTALLDP---------
MAV_1899|M.avium_104 CGGQATILTPQDHRDIVAGRTSIATSCGRETPMCVIRVIDA---------
TH_3186|M.thermoresistible__bu MSPVTTVLDGADTI-------EKLGSVGRPVPLVDARIVDA---------
Mb0102|M.bovis_AF2122/97 TGCTALCLPTDDGS----IVKIEAGAVGRPYPGVDVYLAAT---DGIGPT
Rv0099|M.tuberculosis_H37Rv TGCTALCLPTDDGS----IVKIEAGAVGRPYPGVDVYLAAT---DGIGPT
MMAR_0258|M.marinum_M TGCTALCLPTDDDS----IAKIEAGAVGRPYPGVEVYLAADDEADGAGPN
MUL_4856|M.ulcerans_Agy99 TGCTALCLPTDDGS----IAKIEAGAVGRPYPGVEVYLAADDEADGAGPN
MLBr_01994|M.leprae_Br4923 TGCTALCLPTDNGS----ISKIEAGAVGRPYPGVEVYLADP---NGGGPT
MAB_0661|M.abscessus_ATCC_1997 TGCTALCLPTDSES----ISRIEQGAVGRPYPGVQTYLSPE---GGGDPT
* . : ** :
Mflv_0027|M.gilvum_PYR-GCK TGRDVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDAGYLD
Mvan_0943|M.vanbaalenii_PYR-1 TGADAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGDAGYVD
MSMEG_1098|M.smegmatis_MC2_155 EGNPVPQGEVGEICVSGPLLAGGYWKLPDATAETFK-DGWLHTGDMARED
MAV_1899|M.avium_104 EGNDAPVDEVGEIVIVSPANAVGYWNQPEQTAETFRPDGLR-TGDLGYLD
TH_3186|M.thermoresistible__bu DMNDVPQGEVGEIVYRGPQTMLGYWDNPEETAKAFR-GGWFHSGDLVRAD
Mb0102|M.bovis_AF2122/97 APGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLI-DGWVNTGDLLERR
Rv0099|M.tuberculosis_H37Rv APGAGPSASFGTLWIKSPANMLGYWNNPERTAEVLI-DGWVNTGDLLERR
MMAR_0258|M.marinum_M APGAGPSASFGTLWIKSPANMLGYWSNPQRTQEVLI-DGWVNTGDLLERH
MUL_4856|M.ulcerans_Agy99 APGAGPSASFGTLWIKSPANMLGYWSNPQRTQEVLI-DGWVNTGDLLERH
MLBr_01994|M.leprae_Br4923 VADTASSASFGTLWIKSPANMLGYWNNPERTREILV-DGWVNTGDLVERR
MAB_0661|M.abscessus_ATCC_1997 TG--AESASYGTLWIKSPANMLGYWGSPERTGEVLA-EGWVNTGDLVERR
* : . *** *: * : * :**
Mflv_0027|M.gilvum_PYR-GCK RDGYLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIPDTRW
Mvan_0943|M.vanbaalenii_PYR-1 DDGYLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIGVPDRRW
MSMEG_1098|M.smegmatis_MC2_155 EDGYWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPSVAQVCVIGTPDEKW
MAV_1899|M.avium_104 ADGYLHITGRRTDLIISGGFNVYPAEIERVIAQHPGVDMVAVVGVPDPEW
TH_3186|M.thermoresistible__bu EDGYLYVVDRLKDMIISGGENVYCTEVEAAIAEHLKVREVAVVGAPHPKW
Mb0102|M.bovis_AF2122/97 EDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEF
Rv0099|M.tuberculosis_H37Rv EDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEF
MMAR_0258|M.marinum_M EDGFFYIKGRSSEMIISGGVNIAPDEVDRIAEGVPGVREAACFEIPDPEF
MUL_4856|M.ulcerans_Agy99 EDGFFYIKGRSSEMIISGGVNIAPDEVDRIAEGVPGVREAACFEIPDPEF
MLBr_01994|M.leprae_Br4923 EDGFFYIKGRSSEMIVSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHF
MAB_0661|M.abscessus_ATCC_1997 ADGFFYIRGRSSEMIISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEF
**: .: .* .::*: *. *: *:: * .. *. .:
Mflv_0027|M.gilvum_PYR-GCK GEAVKAVVVAG--APVTE-------AELIAFAREQLAGFKLPKSVDFVDA
Mvan_0943|M.vanbaalenii_PYR-1 GEAVKAVVVAARGAQLTE-------AELIAFARDRIGGFKLPKSVDFVDV
MSMEG_1098|M.smegmatis_MC2_155 GEAVTAVVVLRPDADRSEEGIERLTAEIQASVKERKGSVQSPKQVIVVDS
MAV_1899|M.avium_104 GETPVAAVIPKSHVRDQQ----ALTEELAALCRAELAGYKQPRRFEYRDE
TH_3186|M.thermoresistible__bu GETPVAVVVPRDPDDPPG------SDELIEFTSTRLASYKKPTRVVVVDA
Mb0102|M.bovis_AF2122/97 GALVGLAVVASAELDESAAR--ALKHTIAARFRRESEPMARPSTIVIVTD
Rv0099|M.tuberculosis_H37Rv GALVGLAVVASAELDESAAR--ALKHTIAARFRRESEPMARPSTIVIVTD
MMAR_0258|M.marinum_M GALVGLAVVAATDMDASAAR--KLKHTIAAHYRRESESVARPSTIVIVSE
MUL_4856|M.ulcerans_Agy99 GALVGLAVVAATDVDASAAR--KLKHTIAAHYRRESESVARPSTIVIVSE
MLBr_01994|M.leprae_Br4923 GALVGLAVIPSAELNESTAI--ELKRRIAARYRRESESMARPSKIVIVAD
MAB_0661|M.abscessus_ATCC_1997 GALVGLAVVATTELDGAGTA--ALKQRIAARYRRESESMARPSTIVLVED
* .*: : . * .
Mflv_0027|M.gilvum_PYR-GCK LPRNPSGKLLKRQLREPYWTDEDRHIG--
Mvan_0943|M.vanbaalenii_PYR-1 LPRNPSGKLLKRALREPYWDGADRHIG--
MSMEG_1098|M.smegmatis_MC2_155 VPVTALGKPDKKAVRAQFWEGAARAVG--
MAV_1899|M.avium_104 FPLGPAGKILKREIANQVRHVGSGA----
TH_3186|M.thermoresistible__bu LPRNASGKVLKAPLRDAVRDDS-------
Mb0102|M.bovis_AF2122/97 IPRTQSGKVMRASLAAAATADKARVVVRG
Rv0099|M.tuberculosis_H37Rv IPRTQSGKVMRASLAAAATADKARVVVRG
MMAR_0258|M.marinum_M IPRTQSGKVMRTSLAAAAN----QVQTGG
MUL_4856|M.ulcerans_Agy99 IPRTQSGKVMRTSLATAAN----QVQTGG
MLBr_01994|M.leprae_Br4923 IPRTQSGKVIRATLAAALNGEQLGMVVRD
MAB_0661|M.abscessus_ATCC_1997 IPRTKSGKVMRSALSASLNGARARV----
.* ** : :