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MSYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARLGAIAVMVDDSLPAATVARFSEI TRPAAIIPNEGGGVGAENGERAYPKAQPDSGADEALAMIFTSGTTGEPKAVLLPNRTFFAIPDILRAEGL RWIDWVAGETTYSPLPATHIGGLWWILNGLMHGASCITGGEQGASLRELLVDNEVATACLVPTLLTRLVS ELKLTGTDVPALRFIAYGGSRAIAADVRFIEAAGVRTAQVYGLSETGCTALCLPTDSESISRIEQGAVGR PYPGVQTYLSPEGGGDPTTGAESASYGTLWIKSPANMLGYWGSPERTGEVLAEGWVNTGDLVERRADGFF YIRGRSSEMIISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGALVGLAVVATTELDGAGTAALKQR IAARYRRESESMARPSTIVLVEDIPRTKSGKVMRSALSASLNGARARV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0661 | - | - | 100% (468) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 1e-35 | 27.66% (499) | fatty-acid-CoA ligase FadD |
| M. abscessus ATCC 19977 | MAB_4626c | - | 2e-35 | 26.39% (432) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0102 | fadD10 | 0.0 | 65.73% (499) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 6e-43 | 29.24% (489) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0099 | fadD10 | 0.0 | 65.73% (499) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01994 | fadD10 | 0.0 | 66.53% (490) | acyl-CoA synthetase |
| M. marinum M | MMAR_0258 | fadD10 | 1e-180 | 65.45% (492) | fatty-acid-CoA ligase FadD10 |
| M. avium 104 | MAV_5018 | - | 5e-37 | 27.31% (498) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_1098 | - | 9e-33 | 27.36% (402) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_3186 | - | 1e-41 | 29.94% (481) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_4856 | fadD10 | 0.0 | 65.45% (492) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 1e-46 | 29.18% (490) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0102|M.bovis_AF2122/97 -----------MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGT
Rv0099|M.tuberculosis_H37Rv -----------MGGKKFQAMPQLPSTVLDRVFEQARQQPEAIALRRCDGT
MMAR_0258|M.marinum_M -------------------MSDLPATVLERIIEQAQRRPEAIALRRCDGT
MUL_4856|M.ulcerans_Agy99 -------------------MSDLPATVLERIIEQAQRRPEAIALRRCDGT
MLBr_01994|M.leprae_Br4923 -------------------MSHLPPTVLERILKQAHERPEAIALRRSDGT
MAB_0661|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0027|M.gilvum_PYR-GCK ------------MFHNLADIVRSHGRN----------RPDAPALIVGDRT
Mvan_0943|M.vanbaalenii_PYR-1 ------------MIHNLADIIRVHGRE----------RPGAPALVVGDRT
MSMEG_1098|M.smegmatis_MC2_155 ---------MTQVKSSSPDLLRHPTHSGHLTVAALKRNRDKPVLFLGDTT
MAV_5018|M.avium_104 MLSLTAQLAHHPTQANEQPYLSRRQNWVNQLERHALMQPNATALRFLGKG
TH_3186|M.thermoresistible__bu -------------MSSSTPHPNTALTWVEQVGKHARSQPDRPALRFRGAT
Mb0102|M.bovis_AF2122/97 SALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKL
Rv0099|M.tuberculosis_H37Rv SALRYRELVAEVGGLAADLRAQSVSRGSRVLVISDNGPETYLSVLACAKL
MMAR_0258|M.marinum_M SALPYSELAAEVDRYAGALRAQSASRGSRVLVISDNGPETYLAVLACAKL
MUL_4856|M.ulcerans_Agy99 SALPYGELVAEVDRYAGALRAQSASRGSRVLVISDNGPETYLAVLACAKL
MLBr_01994|M.leprae_Br4923 SELRYGQLVAEVNGLAAHLSAQSVSQRSRVLVISDNGPETYLSVLACAKL
MAB_0661|M.abscessus_ATCC_1997 --MSYGELIGAVEDLAATLEAGSVTHGSRVVVLSDNGPQTYLSVLACARL
Mflv_0027|M.gilvum_PYR-GCK --VSYRELDERSNRTAQAFSRTGVGPGDRVAFVERNGIEFFDVAFGSAKL
Mvan_0943|M.vanbaalenii_PYR-1 --VTYGELDDRSSRAAQAFAQAGVGVGDRVAFVDKNGAEFFEVTFGLAKV
MSMEG_1098|M.smegmatis_MC2_155 --LTGGELADRISQYIQAFEALGAGSGEGVGLLSLNRPEVLMIIGAGQTQ
MAV_5018|M.avium_104 --LTWGELHGRVRALADALSRRGVGFGDRVMVLMLNRPEFMESVLAINML
TH_3186|M.thermoresistible__bu --TTWAQLEERSRKLATALESRGVGHGDRVLILLTNRPEFVETLVAVNRL
:* : .. . * .: * : .
Mb0102|M.bovis_AF2122/97 GAIAVMADG---------NLPIAAIERFCQITDPAAALVAPGSKMASSAV
Rv0099|M.tuberculosis_H37Rv GAIAVMADG---------NLPIAAIERFCQITDPAAALVAPGSKMASSAV
MMAR_0258|M.marinum_M GAIAVMADG---------NLPPATIDRFCQITDPVAVLIAPGSKVGSSSL
MUL_4856|M.ulcerans_Agy99 GAIAVMADG---------NLPPATIDRFCQITDPVAVLIAPGSKVGSSSL
MLBr_01994|M.leprae_Br4923 GAIAVMVDG---------NLPPATISRFSEICDPSAVLVARECRIDSSSL
MAB_0661|M.abscessus_ATCC_1997 GAIAVMVDD---------SLPAATVARFSEITRPAAIIPNEGGGVG----
Mflv_0027|M.gilvum_PYR-GCK GAVAVPVN---------WRLTAPEMRHVIADCGASVVVVGQEFTGRIEAI
Mvan_0943|M.vanbaalenii_PYR-1 GAVGVPVN---------WRLAAPEMRHIIADSGAKIVVVGQDFAGHLEAI
MSMEG_1098|M.smegmatis_MC2_155 GYRRTALHPLGSLDDHAYVLSDAEVTTLIIDPTPAFVERALGLLEKVPTL
MAV_5018|M.avium_104 GAIAVPLN---------FRLTAAEIAFLVQDCQARVVITEAVLAPVATGV
TH_3186|M.thermoresistible__bu GAIAVPVN---------FRLVAAEVAYLAQNSGAGAVVVEQDLAPLVAGV
* . . * . : . .
Mb0102|M.bovis_AF2122/97 PEA-------LHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLA
Rv0099|M.tuberculosis_H37Rv PEA-------LHSIPVIAVDIAAVTRESEHSLDAASLAGNADQGSEDPLA
MMAR_0258|M.marinum_M PEG-------LAAIPAIRVDIGSGTGEFAHSPDTDRPATEPGLGADDPLA
MUL_4856|M.ulcerans_Agy99 PEG-------LAAIPAIRVDIGSGTGEFAHSPDTDRPATEPGLGADDPLA
MLBr_01994|M.leprae_Br4923 PEI-------LHSIPAITVNTTADATYSACSLDIDYLAGNLNYGTDDPLA
MAB_0661|M.abscessus_ATCC_1997 ----------------------------AENGERAYPKAQPDSGADEALA
Mflv_0027|M.gilvum_PYR-GCK ADD------LDVEVVVIGKHRHWPTFDDLLAAAPAVDPGVVTGP-DDLVF
Mvan_0943|M.vanbaalenii_PYR-1 EDG------LDADIVVIGDHPRWPAFDDWVASHPPVDPGVVTGP-DDVVL
MSMEG_1098|M.smegmatis_MC2_155 RQI------LTIGPVPEALAGVATDLNAEAAKYPAKPLVAAELPPDHIGG
MAV_5018|M.avium_104 RDIESLLDTVVVAGGSSDDAVLGYDDLIDETG-AAHQPVDIPNDA--AAL
TH_3186|M.thermoresistible__bu REQRSDVACLVVGS-DPDGAGPGAELYTDAVASAAPHPGTGPDDLRTCAL
Mb0102|M.bovis_AF2122/97 MIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPA
Rv0099|M.tuberculosis_H37Rv MIFTSGTTGEPKAVLLANRTFFAVPDILQKEGLNWVTWVVGETTYSPLPA
MMAR_0258|M.marinum_M MIFTSGTTGEPKAVLLANRTFFAVPDILRNEGLNWVTWVDGETTYSPLPA
MUL_4856|M.ulcerans_Agy99 MIFTSGTTGEPKAVLLANRTFFAVPDILRNEGLNWVTWVDGETTYSPLPA
MLBr_01994|M.leprae_Br4923 MTFTSGTTGEPKAVLLPNRTFFAIPDILREKGLAWIDWVVNETTYSPLSA
MAB_0661|M.abscessus_ATCC_1997 MIFTSGTTGEPKAVLLPNRTFFAIPDILRAEGLRWIDWVAGETTYSPLPA
Mflv_0027|M.gilvum_PYR-GCK LMYTSGTTGAPKGVMLSNANVVCKTAGVGG---PWKFD-ADSVSLAVMPL
Mvan_0943|M.vanbaalenii_PYR-1 LMYTSGTTGAPKGVMLSNTNYVYKTGGVAG---PWQFD-ADAVSLAVMPL
MSMEG_1098|M.smegmatis_MC2_155 LTYTGGTTGKPKGVMGTVRSITTMTTIQLA---EWEWP-ENPRFLMCTPL
MAV_5018|M.avium_104 IMYTSGTTGRPKGAVLTHTNLTGQTMTGLY---TNGADINNDVGFIGVPF
TH_3186|M.thermoresistible__bu IMYTSGTTGRPKGAMLSYQNLLGQTLTLTR---AYNFVRNDEVVAVTSPM
: :*.**** **..: . . . . .
Mb0102|M.bovis_AF2122/97 THIGGLWWILTCLMHGGLCVTGGE---NTTSLLEILTTNAVATTCLVPTL
Rv0099|M.tuberculosis_H37Rv THIGGLWWILTCLMHGGLCVTGGE---NTTSLLEILTTNAVATTCLVPTL
MMAR_0258|M.marinum_M THIGGLWWILTCLMRGGLCITGGE---NTPSLMQILNSNAVNTTCLVPTL
MUL_4856|M.ulcerans_Agy99 THIGGLWWILTCLMRGGLCITGGE---NTLSLMQILNSNAVNTTCLVPTL
MLBr_01994|M.leprae_Br4923 THIGGLWWILNCLMHGGLCITGGE---HTSSLTEVLNANKVATTCLVPTL
MAB_0661|M.abscessus_ATCC_1997 THIGGLWWILNGLMHGASCITGGE---QGASLRELLVDNEVATACLVPTL
Mflv_0027|M.gilvum_PYR-GCK FHMAGFGWALAGLWEGAVTVVLRD--VDPGAILDAVARHRVTNMLLVPAV
Mvan_0943|M.vanbaalenii_PYR-1 FHMAGSGWALAGLWQGATTVVLRD--VEPAAILDAIARHRITNMLLVPAV
MSMEG_1098|M.smegmatis_MC2_155 SHAG-AAFFVPTIVKGGEMIVLPK--FDPGEVLRVIEERRITATMLVPSM
MAV_5018|M.avium_104 FHIAGIGNMLTGLLLGIPTVIYPLGAFEPGQLLDVLAAEKVTGIFLVPAQ
TH_3186|M.thermoresistible__bu FHIAAIGALVPNLILGYPTVITPTGGFDAEEFLDLLESEGVTNAFLVPTQ
* . : : * : . . : . : ***:
Mb0102|M.bovis_AF2122/97 LSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLS
Rv0099|M.tuberculosis_H37Rv LSKLVSELKSANATVPSLRLVGYGGSRAIAADVRFIEATGVRTAQVYGLS
MMAR_0258|M.marinum_M LSKLVSELKSAATTVPSLRLLGYGGSRAIAADVRFIEATGVRTAQVYGLS
MUL_4856|M.ulcerans_Agy99 LSKLVSELKSAATTVPSLRLLGYGGSRAIAADVRFIEATGVRTAQVYGLS
MLBr_01994|M.leprae_Br4923 LSKLVYELKFGDVVTPPLRLIVYGGSRVIAADVRFIEAAGVRTAQFYGLS
MAB_0661|M.abscessus_ATCC_1997 LTRLVSELKLTGTDVPALRFIAYGGSRAIAADVRFIEAAGVRTAQVYGLS
Mflv_0027|M.gilvum_PYR-GCK IQFLLDTTGLDDTDLSRLRIVVYGASPITDDVLMRGIDRFG-GIFAQVYG
Mvan_0943|M.vanbaalenii_PYR-1 IQFLLDTDGVAEVDLSTLRVIVYGASPISDDVLVRGIERFG-PIFAQVYG
MSMEG_1098|M.smegmatis_MC2_155 LYALLDHPDSHTRDLSSLETVYYGASAMNPVRLAEALKRFG-PIFAQYYG
MAV_5018|M.avium_104 WQAVCAEQRARPRDLK-LRVISWGAAPAPDALLREMSAMFPGTQILAAFG
TH_3186|M.thermoresistible__bu WQALCSSPTVRDRKLR-LRTISWGASPATPALLRAMAEVFPDAANVCTFG
: *. : :*.: : .
Mb0102|M.bovis_AF2122/97 ETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAAT---DGIGPTAPG
Rv0099|M.tuberculosis_H37Rv ETGCTALCLPTDDGSIVKIEAGAVGRPYPGVDVYLAAT---DGIGPTAPG
MMAR_0258|M.marinum_M ETGCTALCLPTDDDSIAKIEAGAVGRPYPGVEVYLAADDEADGAGPNAPG
MUL_4856|M.ulcerans_Agy99 ETGCTALCLPTDDGSIAKIEAGAVGRPYPGVEVYLAADDEADGAGPNAPG
MLBr_01994|M.leprae_Br4923 ETGCTALCLPTDNGSISKIEAGAVGRPYPGVEVYLADP---NGGGPTVAD
MAB_0661|M.abscessus_ATCC_1997 ETGCTALCLPTDSESISRIEQGAVGRPYPGVQTYLSPE---GGGDPTTG-
Mflv_0027|M.gilvum_PYR-GCK MTESTGSVTQLDGDEHLPQLLRSCGRPYPWVQIRVVDP---------TGR
Mvan_0943|M.vanbaalenii_PYR-1 MTETTGSITQLDGPDHVPALLRSCGRPYPWVQIRIVDE---------TGA
MSMEG_1098|M.smegmatis_MC2_155 QSEAPMVISYLGKKDHDEKRLTSCGRPTMFARTALLDP---------EGN
MAV_5018|M.avium_104 QTEMSPVTCMLLGEDAIRK-RGSVGKVIPTVAARVVDE---------NMN
TH_3186|M.thermoresistible__bu QTEMSPVTTVLDGADTIEK-LGSVGRPVPLVDARIVDA---------DMN
: . . : *: . :
Mb0102|M.bovis_AF2122/97 AGPSASFGTLWIKSPANMLGYWNNPERTAEVLI-DGWVNTGDLLERREDG
Rv0099|M.tuberculosis_H37Rv AGPSASFGTLWIKSPANMLGYWNNPERTAEVLI-DGWVNTGDLLERREDG
MMAR_0258|M.marinum_M AGPSASFGTLWIKSPANMLGYWSNPQRTQEVLI-DGWVNTGDLLERHEDG
MUL_4856|M.ulcerans_Agy99 AGPSASFGTLWIKSPANMLGYWSNPQRTQEVLI-DGWVNTGDLLERHEDG
MLBr_01994|M.leprae_Br4923 TASSASFGTLWIKSPANMLGYWNNPERTREILV-DGWVNTGDLVERREDG
MAB_0661|M.abscessus_ATCC_1997 -AESASYGTLWIKSPANMLGYWGSPERTGEVLA-EGWVNTGDLVERRADG
Mflv_0027|M.gilvum_PYR-GCK DVAPGTVGEVWTRSDQNMLGYWNNPEATAATLTPDGWLRTGDAGYLDRDG
Mvan_0943|M.vanbaalenii_PYR-1 DAVAGTVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGDAGYVDDDG
MSMEG_1098|M.smegmatis_MC2_155 PVPQGEVGEICVSGPLLAGGYWKLPDATAETFK-DGWLHTGDMAREDEDG
MAV_5018|M.avium_104 DVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFA-GGWFHSGDLVRMDEDG
TH_3186|M.thermoresistible__bu DVPQGEVGEIVYRGPQTMLGYWDNPEETAKAFR-GGWFHSGDLVRADEDG
. * : . *** *: * : **..:** **
Mb0102|M.bovis_AF2122/97 FFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGAL
Rv0099|M.tuberculosis_H37Rv FFYIKGRSSEMIICGGVNIAPDEVDRIAEGVSGVREAACYEIPDEEFGAL
MMAR_0258|M.marinum_M FFYIKGRSSEMIISGGVNIAPDEVDRIAEGVPGVREAACFEIPDPEFGAL
MUL_4856|M.ulcerans_Agy99 FFYIKGRSSEMIISGGVNIAPDEVDRIAEGVPGVREAACFEIPDPEFGAL
MLBr_01994|M.leprae_Br4923 FFYIKGRSSEMIVSGGVNIVPDEVDRIAESVSGVGEAACYEIPDAHFGAL
MAB_0661|M.abscessus_ATCC_1997 FFYIRGRSSEMIISGGVNVVPDEVDRIAEDIAGVREAACYEIPDEEFGAL
Mflv_0027|M.gilvum_PYR-GCK YLYLHDRIKDMIVSGAENVYPAEVENVLMTHPAVTDVAVIGIPDTRWGEA
Mvan_0943|M.vanbaalenii_PYR-1 YLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAAVIGVPDRRWGEA
MSMEG_1098|M.smegmatis_MC2_155 YWFIVDRVKDMIVTGGFNVFPREVEDVVAEHPSVAQVCVIGTPDEKWGEA
MAV_5018|M.avium_104 YVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRAHEKWGEV
TH_3186|M.thermoresistible__bu YLYVVDRLKDMIISGGENVYCTEVEAAIAEHLKVREVAVVGAPHPKWGET
: :: .* .:**: *. *: **: : :.. .. .:*
Mb0102|M.bovis_AF2122/97 VGLAVVASAELDESAAR--ALKHTIAARFRRESEPMARPSTIVIVTDIPR
Rv0099|M.tuberculosis_H37Rv VGLAVVASAELDESAAR--ALKHTIAARFRRESEPMARPSTIVIVTDIPR
MMAR_0258|M.marinum_M VGLAVVAATDMDASAAR--KLKHTIAAHYRRESESVARPSTIVIVSEIPR
MUL_4856|M.ulcerans_Agy99 VGLAVVAATDVDASAAR--KLKHTIAAHYRRESESVARPSTIVIVSEIPR
MLBr_01994|M.leprae_Br4923 VGLAVIPSAELNESTAI--ELKRRIAARYRRESESMARPSKIVIVADIPR
MAB_0661|M.abscessus_ATCC_1997 VGLAVVATTELDGAGTA--ALKQRIAARYRRESESMARPSTIVLVEDIPR
Mflv_0027|M.gilvum_PYR-GCK VKAVVVAG--APVTE-------AELIAFAREQLAGFKLPKSVDFVDALPR
Mvan_0943|M.vanbaalenii_PYR-1 VKAVVVAARGAQLTE-------AELIAFARDRIGGFKLPKSVDFVDVLPR
MSMEG_1098|M.smegmatis_MC2_155 VTAVVVLRPDADRSEEGIERLTAEIQASVKERKGSVQSPKQVIVVDSVPV
MAV_5018|M.avium_104 PIAVAAVAN--DNLAL------EDLDEFLTERLARYKHPKALEIVDALPR
TH_3186|M.thermoresistible__bu PVAVVVPRDPDDPPGS------DELIEFTSTRLASYKKPTRVVVVDALPR
.. : . *. : .* :*
Mb0102|M.bovis_AF2122/97 TQSGKVMRASLAAAATADKARVVVRG
Rv0099|M.tuberculosis_H37Rv TQSGKVMRASLAAAATADKARVVVRG
MMAR_0258|M.marinum_M TQSGKVMRTSLAAAAN----QVQTGG
MUL_4856|M.ulcerans_Agy99 TQSGKVMRTSLATAAN----QVQTGG
MLBr_01994|M.leprae_Br4923 TQSGKVIRATLAAALNGEQLGMVVRD
MAB_0661|M.abscessus_ATCC_1997 TKSGKVMRSALSASLNGARARV----
Mflv_0027|M.gilvum_PYR-GCK NPSGKLLKRQLREPYWTDEDRHIG--
Mvan_0943|M.vanbaalenii_PYR-1 NPSGKLLKRALREPYWDGADRHIG--
MSMEG_1098|M.smegmatis_MC2_155 TALGKPDKKAVRAQFWEGAARAVG--
MAV_5018|M.avium_104 NPAGKVLKTELRIRYGGG--------
TH_3186|M.thermoresistible__bu NASGKVLKAPLRDAVRDDS-------
. ** : :