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MTGLLLAAILAPLAASIASLITGWRRTTATLTALSATTVLACAVAMGFWMGSGAQFGLGGLLRADALTVV MLVVIGIVGTLATAASIGYIDTELAHGHIDGRSARLYGVLTPAFLCAMVLAVCANNIGVIWVAIEATTVI TAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAGLDPGVA RLAGGLLLIGYGAKAGLFPFHTWLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNG LLVVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHGIGKTVLFLAG GQLQAAHDSTAIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASELAIARSLANERLAWVLGAALLL IAIGFTALARNSGRMLLGTPAAGAPAITVPATAAAALMVGIVVSAALGITAGPLADLLGIAASNVGLP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0086 | hycQ | - | 100% (488) | POSSIBLE HYDROGENASE HYCQ |
| M. tuberculosis H37Rv | Rv0083 | - | 5e-38 | 30.28% (436) | oxidoreductase |
| M. tuberculosis H37Rv | Rv3158 | nuoN | 2e-30 | 25.47% (530) | NADH dehydrogenase subunit N |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0089 | hycQ | 0.0 | 99.80% (488) | hydrogenase HycQ |
| M. gilvum PYR-GCK | Mflv_0164 | - | 3e-37 | 27.11% (450) | putative monovalent cation/H+ antiporter subunit D |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0634c | - | 2e-43 | 28.93% (515) | putative monovalent cation/H+ antiporter subunit D |
| M. marinum M | MMAR_1658 | hycQ | 0.0 | 72.22% (486) | hydrogenase HycQ |
| M. avium 104 | MAV_5110 | - | 0.0 | 77.98% (486) | hydrogenase-4, F subunit, putative |
| M. smegmatis MC2 155 | MSMEG_0846 | - | 3e-37 | 27.65% (434) | putative monovalent cation/H+ antiporter subunit D |
| M. thermoresistible (build 8) | TH_4005 | - | 8e-38 | 27.39% (471) | PUTATIVE NADH-ubiquinone oxidoreductase/multisubunit na+/h+ |
| M. ulcerans Agy99 | MUL_1895 | hycQ | 0.0 | 72.22% (486) | hydrogenase HycQ |
| M. vanbaalenii PYR-1 | Mvan_0742 | - | 1e-38 | 27.74% (429) | putative monovalent cation/H+ antiporter subunit D |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0846|M.smegmatis_MC2_155 ----MMVQTLIPLPVLIPTLAAAATLIAGRRPHLQRAIAQIALTAVVAVC
TH_4005|M.thermoresistible__bu ---MNLAATLTPLPVLIPTLSAAATLIAGRRVRLQRMIALLSLTAMVAVC
Mflv_0164|M.gilvum_PYR-GCK MIGAHLASVLTPLPVLIPMLGAAATLIAGRRPRLQRAIVVSGLSAVVAVS
Mvan_0742|M.vanbaalenii_PYR-1 MIGAQFASVLTPLPVLVPMLAAAATLIAGRRPRLQRSIVVLALSTVVAVS
MAB_0634c|M.abscessus_ATCC_199 ---MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVC
Rv0086|M.tuberculosis_H37Rv ------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALSATTVLACA
Mb0089|M.bovis_AF2122/97 ------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALSATTVLACA
MAV_5110|M.avium_104 ------MTALLLAAILAPLAAAGAAAALGWR-RLTSTVTVLSAATVLGCG
MMAR_1658|M.marinum_M ------MTALILVPIVAPLVAAAFALAGGWR-RATAVLTVLSAVAVLGSG
MUL_1895|M.ulcerans_Agy99 ------MTALILVPIVAPLVAAAFALAGGWR-RATAVLTVLSAVAVLGSG
* .:: * .: : * * : :. . :::.
MSMEG_0846|M.smegmatis_MC2_155 GVLLYLSDRDGTLVLHVGGWDQAIPGMGPLGITLVVDRLSALMLVVSSIV
TH_4005|M.thermoresistible__bu AVLLYLTDRDGTVVVHVGGWGEIVGGLGPLGITLVVDRLAAMMLVVSSIV
Mflv_0164|M.gilvum_PYR-GCK AALLYLADRDGTIALQVGGWGPTEDGLGPLGVTLVVDRLSALMLVVSSIV
Mvan_0742|M.vanbaalenii_PYR-1 AALLYLADRDGTFALQVGGWGSTEAGMGPLGVTLVVDRLSALMLVVSSIV
MAB_0634c|M.abscessus_ATCC_199 TALLYLTDRDGTFALAVGGWGPTEEKLGPLGITLVVDRLSALMLVVSAIV
Rv0086|M.tuberculosis_H37Rv VAMGFWMGSGAQFGLG-----------GLLRADALTVVMLVVIGIVGTLA
Mb0089|M.bovis_AF2122/97 VAMGFWMGSGAQFGLG-----------GLLRADALTVVMLVVIGIVGTLA
MAV_5110|M.avium_104 AALSFTVGSQQYFVLG-----------GLLRVDALCVTMLIVIGIVGTLA
MMAR_1658|M.marinum_M IALGLQATPQPHLVLG-----------GLLRVDALSVIMLIVIGAVGTLA
MUL_1895|M.ulcerans_Agy99 IALGLQATPQPHLVLG-----------GLLRVDALSVIMLIVIGAVGTLA
.: . : * * : : :: *.::.
MSMEG_0846|M.smegmatis_MC2_155 LLAVVVYAIGQGIRDGDERQPVSIFMPTYLVLSAGVYTAFLAGDLFNLFV
TH_4005|M.thermoresistible__bu LLAVVQYAIGQGVRDGDERQPVSIFIPTYLVLSAGVCMAFVAGDLFNLFV
Mflv_0164|M.gilvum_PYR-GCK LLAVVFYAIGQGIRDGDERQPVSIFLPTYLVLSAGVFMAFLAGDLFNLFV
Mvan_0742|M.vanbaalenii_PYR-1 LLAVVFYAIGQGIRDGDERQPVSIFLPTYLVLSAGVFMAFLAGDLFNLFV
MAB_0634c|M.abscessus_ATCC_199 LLAVVLYAAAQGIRDGDERQPVSIFMPTYLALSAGVCNAFLAGDLFNLYV
Rv0086|M.tuberculosis_H37Rv TAASIGYIDTELAHGHIDGRSARLYGVLTPAFLCAMVLAVCANNIGVIWV
Mb0089|M.bovis_AF2122/97 TAASIGYIDTELAHGHIDGRSARLYGVLTPAFLCATVLAVCANNIGVIWV
MAV_5110|M.avium_104 TWASIGYIDAECADGHTDAGGARLYGALTPAFLAAMVVAVCANNIGVIWV
MMAR_1658|M.marinum_M TWASIGYIDAELEHGHTDRRDARLYGALMPAFLAAMAIAVSANNIGLIWV
MUL_1895|M.ulcerans_Agy99 TWASIGYIDAELEHGHTDRRDARLYGALMPAFLAAMAIAVSANNIGLIWV
* : * : . : . :: .: .. *. *.:: ::*
MSMEG_0846|M.smegmatis_MC2_155 GFEVLLAASFVLLTIGASADRVRAGISYVLVSMVSSMIFLIGIALVYAST
TH_4005|M.thermoresistible__bu GFEVLLTASFVLLTIGASEERVRAGTYYVMVSMVSSLIFLAGIGLVYAAT
Mflv_0164|M.gilvum_PYR-GCK GFEVLLTASFVLLTIGASKERVRAGISYVMVSMVSSLVFLFGIALVYATT
Mvan_0742|M.vanbaalenii_PYR-1 GFEVLLTASFVLLTIGASKERVRAGISYVMVSMVSSLVFLFGIALVYATT
MAB_0634c|M.abscessus_ATCC_199 GFEVLLAASFVLLTIGASADRVRAGISYVMVSMMSSVVFLLGIAFVYAAT
Rv0086|M.tuberculosis_H37Rv AIEATTVITAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
Mb0089|M.bovis_AF2122/97 AIEATTVITAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
MAV_5110|M.avium_104 AIEATTVITAFLVGHRRTRTALEATWKYVIICSVGIAIAFLGTVLLYFAA
MMAR_1658|M.marinum_M AVEATTVVTAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
MUL_1895|M.ulcerans_Agy99 AVEATTVVTAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
..*. . : .*: : :.* **::. :. : : * ::* ::
MSMEG_0846|M.smegmatis_MC2_155 G--------TLNLAELGVRLTDLPPGTRTAIFAVLLVAFGIKAAVFPLSA
TH_4005|M.thermoresistible__bu G--------TLNMAELAVRLDDIAPGTRTALFAVLLIAFGIKAAVFPLSS
Mflv_0164|M.gilvum_PYR-GCK G--------TLNLAEIAVRLDDVPEGTRMALFAVLLVAFGIKAAVFPLSA
Mvan_0742|M.vanbaalenii_PYR-1 G--------TLNLAEIAVRLDDVPEGTRMALFAVLLVAFGIKAAVFPLSA
MAB_0634c|M.abscessus_ATCC_199 G--------TLNMAEIALRADGIPSGTRMAIFAVLLVGFAIKAAVFPLST
Rv0086|M.tuberculosis_H37Rv RDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLLIGYGAKAGLFPFHT
Mb0089|M.bovis_AF2122/97 RDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLLIGYGAKAGLFPFHT
MAV_5110|M.avium_104 RHAGASAALALNLDVLGAHAHTLDPAVSRLAGGLLLIGYGAKAGLAPFHT
MMAR_1658|M.marinum_M QHAGADGANALNLDVLTACAAHLNPAVTRLAGGLLLIGYGAKVGLAPFHG
MUL_1895|M.ulcerans_Agy99 QHAGADGANALNLDVLTACAAHLNPAVTRLAGGLLLIGYGAKVGLAPFHG
:**: : : .. .:**:.:. *..: *:
MSMEG_0846|M.smegmatis_MC2_155 WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPDGG---LDSVLL
TH_4005|M.thermoresistible__bu WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRTHSLLFPGAG---LDPLLL
Mflv_0164|M.gilvum_PYR-GCK WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGG---MDRILL
Mvan_0742|M.vanbaalenii_PYR-1 WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGG---MDRVLL
MAB_0634c|M.abscessus_ATCC_199 WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGG---LNTVLL
Rv0086|M.tuberculosis_H37Rv WLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNGLL
Mb0089|M.bovis_AF2122/97 WLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNGLL
MAV_5110|M.avium_104 WLADAHSQAPAPVSALMSGVLLSVAMSVLIRITPIVGAAAGPTFLRAGLL
MMAR_1658|M.marinum_M WLADAHSQAPAPVSALMSGVLLSVAFSVLIRLRPVIDAAVGPGYLRAGLL
MUL_1895|M.ulcerans_Agy99 WLADAHSQAPAPVSALMSGVLLSVAFSVLIRLRPVIDAAVGPGYLRAGLL
**.*::. *****:*:::*:* *.. .:** .:: . * : **
MSMEG_0846|M.smegmatis_MC2_155 VAGLLTMVIGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALGNELGMAGA
TH_4005|M.thermoresistible__bu IAALATMLIGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTQLGMSGA
Mflv_0164|M.gilvum_PYR-GCK VAGLLTMVIGIFGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTQLGMAGA
Mvan_0742|M.vanbaalenii_PYR-1 VAGLLTMIIGIFGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTHLGMSGA
MAB_0634c|M.abscessus_ATCC_199 VAALLTMIVGILGAIAQSDIKRLLSFTLVSHIGYMIFGIALSNELGMSGA
Rv0086|M.tuberculosis_H37Rv VVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAAL
Mb0089|M.bovis_AF2122/97 VVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAAL
MAV_5110|M.avium_104 TVGLVTLFVAALMLTVTGDVKRMLAYSSMENMGLIAIAAAAGTTLAIAAL
MMAR_1658|M.marinum_M TVGLTTVLIAAFLLTVVTDLKRMLAYSSMENMGLIAIAAAAGTKLAIAAL
MUL_1895|M.ulcerans_Agy99 TVGLTTVLIAAFLLTVVTDLKRMLAYSSMENMGLIAIAAAAGTKLAIAAL
..* *:.:. : . *:**:*::: :.::* : :. * .. *.::.
MSMEG_0846|M.smegmatis_MC2_155 IYYVAHHIVVQTTLFLVVGLIERQAGASTLQRLGGLAAASPVLAFVWVVP
TH_4005|M.thermoresistible__bu IYYVAHHIVVQTTLFLVVGLIERQAGASTLQRLGGLAAASPLLAFVFVVP
Mflv_0164|M.gilvum_PYR-GCK IYYVAHHILVQTTLFLVVGLIERQAGASTLERLGGLAAASPLLAFVFVVP
Mvan_0742|M.vanbaalenii_PYR-1 IYYVAHHILVQTTLFLVVGLIERQAGASTLERLGGLAAASPLLAFVFVVP
MAB_0634c|M.abscessus_ATCC_199 IYYVAHHIIVQTTLFLVVGLIERQAGASSLNRLGGLAAASPLLAFVFVVP
Rv0086|M.tuberculosis_H37Rv LLHVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVG
Mb0089|M.bovis_AF2122/97 LLHVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVG
MAV_5110|M.avium_104 LLHVLAHGVGKTVLFLAGGQLQAAHGSTAIADITGVVQRSHLIGGSFAVG
MMAR_1658|M.marinum_M LLHVLAHGIGKTVLFLAGGQLQSAHDSASIADITAVLSRSRVVGVSFAVG
MUL_1895|M.ulcerans_Agy99 LLHVLAHGIGKTVLFLAGGQLQSAHDSASIADITAVLSRSRVVGVSFAVG
: :* * : :*.***. * :: .:::: : .: * ::. :.*
MSMEG_0846|M.smegmatis_MC2_155 ALNLGGIPPFSGFIGKIALMEAGAANGSALAWTLVAGGVVTSLLTLYVVA
TH_4005|M.thermoresistible__bu ALNLGGIPPFSGFIGKVALMEAGAADGSVLAWTLVGGSVVTSLLTLYVVA
Mflv_0164|M.gilvum_PYR-GCK ALNLGGIPPFSGFIGKVALLEAGAESGSVLAWILVAGSVITSLLTLYVVA
Mvan_0742|M.vanbaalenii_PYR-1 ALNLGGIPPFSGFIGKVALLEAGAQSGSVLAWALVAGSVATSLLTLYVVA
MAB_0634c|M.abscessus_ATCC_199 ALNLGGIPPFSGFIGKVALLEAGSLQGSVLAWALVAGGTITSLLTLYAVA
Rv0086|M.tuberculosis_H37Rv LIVLLGLPPFAMFASELAIARSLANER--LAWVLGAALLLIAIGFTALAR
Mb0089|M.bovis_AF2122/97 LIVLLGLPPFAMFASELAIARSLANER--LAWVLGAALLLIAIGFTALAR
MAV_5110|M.avium_104 LIVLLGLPPFAMFASELALAHALADAR--LAWVLGAAMLLIAIAFAALVR
MMAR_1658|M.marinum_M VVVLLGLPPFAMFASEVSIARSLADSG--LAWVLGVTLLLMVVAFAALVA
MUL_1895|M.ulcerans_Agy99 VVVLLGLPPFAMFSSEVSIARSLANSG--LAWVLGVTLLLMVVAFAALVA
: * *:***: * .:::: .: : *** * : .
MSMEG_0846|M.smegmatis_MC2_155 RVWTKAFWRTRADAPEGHLSQAAPAVLLD---DGEDIEYADREGVGRMPI
TH_4005|M.thermoresistible__bu RVWTKAFWRSRADAPEGHLSAAAPAVLLD---DIEDIEFAERRHVGRMPV
Mflv_0164|M.gilvum_PYR-GCK RVWTKAFWRARKDAPEGHLSGPAPTALLDNTDETMDIEHSDRDDVGRMPV
Mvan_0742|M.vanbaalenii_PYR-1 RVWTKAFWRSRKDAPEGHLSGPAPAALLDNTDETMDIELADRDDVGRMPV
MAB_0634c|M.abscessus_ATCC_199 RVWTKAFWRPRSDAPEGDLAAAAPTALLD---DAEDVAFVDRADVGRIPA
Rv0086|M.tuberculosis_H37Rv NSGRMLLGTPAAGAPAITVPATAAAALMVG--------------------
Mb0089|M.bovis_AF2122/97 NSGRMLLGTPAAGAPAITVPATAAAALMVG--------------------
MAV_5110|M.avium_104 NASRMLLGPAAAAAPPITAPTTVTAALLVG--------------------
MMAR_1658|M.marinum_M NSRRMLLGAASEGAPRIAVPATVAAALVTG--------------------
MUL_1895|M.ulcerans_Agy99 NSRRMLLGAASEGAPRIAVPATVAAALVTG--------------------
. : . ** . ...:.*:
MSMEG_0846|M.smegmatis_MC2_155 GMLIPTAALIVVGLVLTVAAGPIFAFSERAAAEVIDRGQYITAVLGETR-
TH_4005|M.thermoresistible__bu SMLVPTGGLILVGLALTIFAGPIVAYSERAAEQVLDRGRYIGAVIGEAP-
Mflv_0164|M.gilvum_PYR-GCK GMLAPTGALIVVGLALTVLAGPIIAYSDRAAAEVLDRSQYIGAVLGGQP-
Mvan_0742|M.vanbaalenii_PYR-1 GMLAPTGALIVVGLLLTILAGPIFGYSDRAAGEVIDRGQYIGAVLGGTR-
MAB_0634c|M.abscessus_ATCC_199 GMLAPTLGLIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR
Rv0086|M.tuberculosis_H37Rv ---------IVVSAALGITAGPLADLLGIAASNVGLP-------------
Mb0089|M.bovis_AF2122/97 ---------IVVSAALGITAGPLADLLGIAASNVGLP-------------
MAV_5110|M.avium_104 ---------VAASIVLGVTAGPLTDLFSTAAGQLGALR------------
MMAR_1658|M.marinum_M ---------VVACIALGVTAGPLGGLFDAAAGQFGAN-------------
MUL_1895|M.ulcerans_Agy99 ---------VVACIALGVTAGPLGGLFDAAAGQFGAN-------------
: . * : ***: ** :.