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MVQTLIPLPVLIPTLAAAATLIAGRRPHLQRAIAQIALTAVVAVCGVLLYLSDRDGTLVLHVGGWDQAIP GMGPLGITLVVDRLSALMLVVSSIVLLAVVVYAIGQGIRDGDERQPVSIFMPTYLVLSAGVYTAFLAGDL FNLFVGFEVLLAASFVLLTIGASADRVRAGISYVLVSMVSSMIFLIGIALVYASTGTLNLAELGVRLTDL PPGTRTAIFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPDGGLD SVLLVAGLLTMVIGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALGNELGMAGAIYYVAHHIVVQTTLFL VVGLIERQAGASTLQRLGGLAAASPVLAFVWVVPALNLGGIPPFSGFIGKIALMEAGAANGSALAWTLVA GGVVTSLLTLYVVARVWTKAFWRTRADAPEGHLSQAAPAVLLDDGEDIEYADREGVGRMPIGMLIPTAAL IVVGLVLTVAAGPIFAFSERAAAEVIDRGQYITAVLGETR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0846 | - | - | 100% (531) | putative monovalent cation/H+ antiporter subunit D |
| M. smegmatis MC2 155 | MSMEG_2050 | nuoN | 4e-37 | 28.54% (466) | NADH dehydrogenase subunit N |
| M. smegmatis MC2 155 | MSMEG_2052 | nuoL | 2e-34 | 26.65% (469) | NADH dehydrogenase subunit L |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0086 | - | 2e-37 | 28.66% (499) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0164 | - | 0.0 | 82.45% (530) | putative monovalent cation/H+ antiporter subunit D |
| M. tuberculosis H37Rv | Rv0086 | hycQ | 2e-37 | 27.65% (434) | hydrogenase HycQ |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0634c | - | 0.0 | 78.71% (526) | putative monovalent cation/H+ antiporter subunit D |
| M. marinum M | MMAR_1470 | nuoN | 1e-36 | 31.05% (351) | NADH dehydrogenase I (chain N) NuoN (NADH- ubiquinone |
| M. avium 104 | MAV_4047 | - | 3e-39 | 33.33% (351) | NADH dehydrogenase subunit N |
| M. thermoresistible (build 8) | TH_4005 | - | 0.0 | 82.58% (528) | PUTATIVE NADH-ubiquinone oxidoreductase/multisubunit na+/h+ |
| M. ulcerans Agy99 | MUL_2472 | nuoN | 2e-35 | 30.48% (351) | NADH dehydrogenase subunit N |
| M. vanbaalenii PYR-1 | Mvan_0742 | - | 0.0 | 83.18% (529) | putative monovalent cation/H+ antiporter subunit D |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0846|M.smegmatis_MC2_155 ------------MMVQTLIPLPVLIPTLAAAATLIAGRRPHLQRAIAQIA
TH_4005|M.thermoresistible__bu -----------MNLAATLTPLPVLIPTLSAAATLIAGRRVRLQRMIALLS
Mflv_0164|M.gilvum_PYR-GCK --------MIGAHLASVLTPLPVLIPMLGAAATLIAGRRPRLQRAIVVSG
Mvan_0742|M.vanbaalenii_PYR-1 --------MIGAQFASVLTPLPVLVPMLAAAATLIAGRRPRLQRSIVVLA
MAB_0634c|M.abscessus_ATCC_199 -----------MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTA
MMAR_1470|M.marinum_M -MILPSPSIEYFLLCPMLIVFGIAVIGVLAEAFLPRRLRYGAQVTLALSG
MUL_2472|M.ulcerans_Agy99 -MILPSPSIEYFLLCPMLIVFGIAVVGVLAEAFLPRRLRYGAQVTLALSG
MAV_4047|M.avium_104 MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGG
Rv0086|M.tuberculosis_H37Rv --------------MTGLLLAAILAPLAASIASLITGWRRTTATLTALSA
Mb0086|M.bovis_AF2122/97 ------------------------MTAAPTAGGVVTSGVGVAGVGVGLLG
: : .
MSMEG_0846|M.smegmatis_MC2_155 LTAVVAVCGVLLYLSDRDGTLVLHVGGWDQAIPGMGPLGITLVVDRLSAL
TH_4005|M.thermoresistible__bu LTAMVAVCAVLLYLTDRDGTVVVHVGGWGEIVGGLGPLGITLVVDRLAAM
Mflv_0164|M.gilvum_PYR-GCK LSAVVAVSAALLYLADRDGTIALQVGGWGPTEDGLGPLGVTLVVDRLSAL
Mvan_0742|M.vanbaalenii_PYR-1 LSTVVAVSAALLYLADRDGTFALQVGGWGSTEAGMGPLGVTLVVDRLSAL
MAB_0634c|M.abscessus_ATCC_199 LTTVLGVCTALLYLTDRDGTFALAVGGWGPTEEKLGPLGITLVVDRLSAL
MMAR_1470|M.marinum_M LVAAFVAVIVVARSIPVTG-RRAVLGSMAVDRPTLFLQGTVLLVAVMAVI
MUL_2472|M.ulcerans_Agy99 LVAAFVAVIVVARSIPVTG-RRAVLGSMAVDRPTLFLQGTVLLVEVMAVI
MAV_4047|M.avium_104 LVAALFAVIEVAESLPASG-RAAVLGAMAIDRPTLYLQGTVLLVAVMAVI
Rv0086|M.tuberculosis_H37Rv TTVLACAVAMGFWMG-----SGAQFGLGGLLRADALTVVMLVVIGIVGTL
Mb0086|M.bovis_AF2122/97 MFGPVRVVHVGWLLP---------------------LSGVHIELDRLGGF
. : : :. :
MSMEG_0846|M.smegmatis_MC2_155 MLVVS-SIVLLAVVVYAIGQGIRDGDERQPVSIFMP--------------
TH_4005|M.thermoresistible__bu MLVVS-SIVLLAVVQYAIGQGVRDGDERQPVSIFIP--------------
Mflv_0164|M.gilvum_PYR-GCK MLVVS-SIVLLAVVFYAIGQGIRDGDERQPVSIFLP--------------
Mvan_0742|M.vanbaalenii_PYR-1 MLVVS-SIVLLAVVFYAIGQGIRDGDERQPVSIFLP--------------
MAB_0634c|M.abscessus_ATCC_199 MLVVS-AIVLLAVVLYAAAQGIRDGDERQPVSIFMP--------------
MMAR_1470|M.marinum_M FIAERSAHRVAAQTKTAVAAGSGGLDSFTPQASAVPGSDAEREAQRAGAA
MUL_2472|M.ulcerans_Agy99 FIAERSAHRVAAQTKTAVAAGSGGLDSFTPQASAVPGSDAEREAQRAGVA
MAV_4047|M.avium_104 FIAER--TQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERAGAA
Rv0086|M.tuberculosis_H37Rv ATAAS-----IGYIDTELAHGHIDGRSARLYGVLTP--------------
Mb0086|M.bovis_AF2122/97 FMALT-GAVAAPVGCYLIGYVRREHLG-RVPMAVVP--------------
. *
MSMEG_0846|M.smegmatis_MC2_155 -----TYLVLSAGVYTAFLAG-DLFNLFVGFEVLLAASFVLLTIGASADR
TH_4005|M.thermoresistible__bu -----TYLVLSAGVCMAFVAG-DLFNLFVGFEVLLTASFVLLTIGASEER
Mflv_0164|M.gilvum_PYR-GCK -----TYLVLSAGVFMAFLAG-DLFNLFVGFEVLLTASFVLLTIGASKER
Mvan_0742|M.vanbaalenii_PYR-1 -----TYLVLSAGVFMAFLAG-DLFNLFVGFEVLLTASFVLLTIGASKER
MAB_0634c|M.abscessus_ATCC_199 -----TYLALSAGVCNAFLAG-DLFNLYVGFEVLLAASFVLLTIGASADR
MMAR_1470|M.marinum_M QTEIFPLLTLSVGGMMVFPAANDLLTMFVALEVLSLPLYLMCGLARHRRL
MUL_2472|M.ulcerans_Agy99 QTEIFPLLTLSVGGMMVFPAANDLLTMFVALEVLSLPLYLMCGLARHRRL
MAV_4047|M.avium_104 QTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARHRRL
Rv0086|M.tuberculosis_H37Rv --------AFLCAMVLAVCAN-NIGVIWVAIEATTVITAFLVGHRRTRTA
Mb0086|M.bovis_AF2122/97 ---------LFVAAMLLVPAAGSVTTFLLAWELMAIASLILVLSEHARPQ
: . . * .: : :. * .:
MSMEG_0846|M.smegmatis_MC2_155 VR--AGISYVLVSMVSSMIFLIGIALVYAST--------GTLNLAELGVR
TH_4005|M.thermoresistible__bu VR--AGTYYVMVSMVSSLIFLAGIGLVYAAT--------GTLNMAELAVR
Mflv_0164|M.gilvum_PYR-GCK VR--AGISYVMVSMVSSLVFLFGIALVYATT--------GTLNLAEIAVR
Mvan_0742|M.vanbaalenii_PYR-1 VR--AGISYVMVSMVSSLVFLFGIALVYATT--------GTLNLAEIAVR
MAB_0634c|M.abscessus_ATCC_199 VR--AGISYVMVSMMSSVVFLLGIAFVYAAT--------GTLNMAEIALR
MMAR_1470|M.marinum_M LSQESALKYFLLGAFSSAFFLYGVALLYGAT--------GSLTLTGIRDS
MUL_2472|M.ulcerans_Agy99 LSQESALKYFLLGAFSSAVFLYGVALLYGAT--------DSLTLTGIRDS
MAV_4047|M.avium_104 LSQEAAMKYFLLGAFSSAFFLYGVALLYGAT--------GTLLLTGIRDA
Rv0086|M.tuberculosis_H37Rv LE--ATWKYVVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEH
Mb0086|M.bovis_AF2122/97 VR-SAGLWYAVMTQLGFIAILVGLVVLAAAG--------GSDRFAGLGAV
: : * :: .. : * .: : .: : :
MSMEG_0846|M.smegmatis_MC2_155 LTDLPPGTRTAI-FAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFA
TH_4005|M.thermoresistible__bu LDDIAPGTRTAL-FAVLLIAFGIKAAVFPLSSWLPDSYPTAPAPVTAVFA
Mflv_0164|M.gilvum_PYR-GCK LDDVPEGTRMAL-FAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFA
Mvan_0742|M.vanbaalenii_PYR-1 LDDVPEGTRMAL-FAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFA
MAB_0634c|M.abscessus_ATCC_199 ADGIPSGTRMAI-FAVLLVGFAIKAAVFPLSTWLPDSYPTAPAPVTAVFA
MMAR_1470|M.marinum_M LTARSDMSMALVGVGLLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMA
MUL_2472|M.ulcerans_Agy99 LAARSDMSMALVGVGLLSVGLLFKVGAVPFHSWIPDVYQGAPTPTTGFMA
MAV_4047|M.avium_104 LITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMA
Rv0086|M.tuberculosis_H37Rv AAGLDPG-VARLAGGLLLIGYGAKAGLFPFHTWLADAHSQAPAPVSALMS
Mb0086|M.bovis_AF2122/97 CDGVRVAVFMLT-----LVGFGSKAGLVPLHAWLPRAHPEAPSPVSALMS
:. *.. .*: :*:. : **:* :..::
MSMEG_0846|M.smegmatis_MC2_155 GLLTKVGVYAIIRAHSLLFP---DGGLDSVLLVAGLLTMVIGILGAIAQS
TH_4005|M.thermoresistible__bu GLLTKVGVYAIIRTHSLLFP---GAGLDPLLLIAALATMLIGILGAIAQS
Mflv_0164|M.gilvum_PYR-GCK GLLTKVGVYAIIRAHSLLFP---GGGMDRILLVAGLLTMVIGIFGAIAQS
Mvan_0742|M.vanbaalenii_PYR-1 GLLTKVGVYAIIRAHSLLFP---GGGMDRVLLVAGLLTMIIGIFGAIAQS
MAB_0634c|M.abscessus_ATCC_199 GLLTKVGVYAIIRAHSLLFP---GGGLNTVLLVAALLTMIVGILGAIAQS
MMAR_1470|M.marinum_M AATKVAAFGALLRVVYVALPPL-HDQWRPVLWAISILTMAVGTITAVNQT
MUL_2472|M.ulcerans_Agy99 AATKVAAFGALLRVVYVALPPL-HDQWRPVLWAISILTMAVGTITAVNQT
MAV_4047|M.avium_104 AATKVAAFGALLRVVYVALPPL-HDQWRPVLWTISILTMAVGTITAVNQS
Rv0086|M.tuberculosis_H37Rv GVLLAVAFSVLIRLRPILDAVSGPAYLRNGLLVVGLATLLVAVLMLTVTG
Mb0086|M.bovis_AF2122/97 AAMVNLGIYGIVRFDLQLLGPG-PRWWGLALLAVGGTSALYGVLQASVAA
. .. ::* * . : . :
MSMEG_0846|M.smegmatis_MC2_155 DIKRLLSFTLVSHIGYMVFGIALG-----------NELGMAGAIYYVAHH
TH_4005|M.thermoresistible__bu DIKRLLSFTLVSHIGYMVFGIALS-----------TQLGMSGAIYYVAHH
Mflv_0164|M.gilvum_PYR-GCK DIKRLLSFTLVSHIGYMVFGIALS-----------TQLGMAGAIYYVAHH
Mvan_0742|M.vanbaalenii_PYR-1 DIKRLLSFTLVSHIGYMVFGIALS-----------THLGMSGAIYYVAHH
MAB_0634c|M.abscessus_ATCC_199 DIKRLLSFTLVSHIGYMIFGIALS-----------NELGMSGAIYYVAHH
MMAR_1470|M.marinum_M NVKRMLAYSSVAHVGFILTGVIAD-----------NSAGLSATLFYLVAY
MUL_2472|M.ulcerans_Agy99 NVKRMLAYSSVAHVGFILTGVIAD-----------NSAGLSATLFYLVAY
MAV_4047|M.avium_104 DVKRMLAYSSVAHVGFILTGVIAD-----------NHTGLSATLFYLLAY
Rv0086|M.tuberculosis_H37Rv DVKRMLAYSSMEHMGLIAIAAAAG-----------TTLAIAALLLHVLAH
Mb0086|M.bovis_AF2122/97 DLKRLLAYSTTENMGLITLALGAATLFADTGAYGPASIAAAAAMLHMIAH
::**:*::: ::* : . . :. : :: :
MSMEG_0846|M.smegmatis_MC2_155 IVVQTTLFLVVGLIERQAGAS--TLQRLGGLAAASPVLAFVWVVPALNLG
TH_4005|M.thermoresistible__bu IVVQTTLFLVVGLIERQAGAS--TLQRLGGLAAASPLLAFVFVVPALNLG
Mflv_0164|M.gilvum_PYR-GCK ILVQTTLFLVVGLIERQAGAS--TLERLGGLAAASPLLAFVFVVPALNLG
Mvan_0742|M.vanbaalenii_PYR-1 ILVQTTLFLVVGLIERQAGAS--TLERLGGLAAASPLLAFVFVVPALNLG
MAB_0634c|M.abscessus_ATCC_199 IIVQTTLFLVVGLIERQAGAS--SLNRLGGLAAASPLLAFVFVVPALNLG
MMAR_1470|M.marinum_M SFSTVGAFAIVGLVRDANGVEDANLSHWAGLGQRSPIVGVMLSMFLLAFA
MUL_2472|M.ulcerans_Agy99 SFSTVGAFAIVGLVRDADGVEDANLSHWAGLGQRSPIVGVMLSMFLLAFA
MAV_4047|M.avium_104 SFSTVGAFAIVGLIRDADGVEDATLSHWAGLGQRSPIVGVMFSMFLLAFA
Rv0086|M.tuberculosis_H37Rv GIGKTVLFLAGGQLQAAHDST--AIADITGVMRRSRLIGVSFAVGLIVLL
Mb0086|M.bovis_AF2122/97 AAFKSLAFMAAGSVLAATGLR--DLDLLGGLARRMPATTVFFGVAALGAC
* * : . : *: . : :
MSMEG_0846|M.smegmatis_MC2_155 GIPPFSGFIGKIALMEAGAANGS--------ALAWTLVAGGVVTSLLTLY
TH_4005|M.thermoresistible__bu GIPPFSGFIGKVALMEAGAADGS--------VLAWTLVGGSVVTSLLTLY
Mflv_0164|M.gilvum_PYR-GCK GIPPFSGFIGKVALLEAGAESGS--------VLAWILVAGSVITSLLTLY
Mvan_0742|M.vanbaalenii_PYR-1 GIPPFSGFIGKVALLEAGAQSGS--------VLAWALVAGSVATSLLTLY
MAB_0634c|M.abscessus_ATCC_199 GIPPFSGFIGKVALLEAGSLQGS--------VLAWALVAGGTITSLLTLY
MMAR_1470|M.marinum_M GIPLTSGFISKFSVFKAAAEGG-----------AAPLVVIGVISSGVAAY
MUL_2472|M.ulcerans_Agy99 GIPLTSGFISKFSVFKAAAEGG-----------AAPLVVIGVISSGVAAY
MAV_4047|M.avium_104 GIPLTSGFVSKLAVFKAAAQGG-----------AVPLVIVGVVASGVAAY
Rv0086|M.tuberculosis_H37Rv GLPPFAMFASELAIARSLANER----------LAWVLGAALLLIAIGFTA
Mb0086|M.bovis_AF2122/97 GLPLGAGFVSEWLLVQSLIHAAPGHDPIVALTTPLAVGVVALATGLSVAA
*:* : * .: : .: . : .
MSMEG_0846|M.smegmatis_MC2_155 VVARVWTKAFWRTRADAPEGH----------LSQAAPAVLLD--------
TH_4005|M.thermoresistible__bu VVARVWTKAFWRSRADAPEGH----------LSAAAPAVLLD--------
Mflv_0164|M.gilvum_PYR-GCK VVARVWTKAFWRARKDAPEGH----------LSGPAPTALLDNTD-----
Mvan_0742|M.vanbaalenii_PYR-1 VVARVWTKAFWRSRKDAPEGH----------LSGPAPAALLDNTD-----
MAB_0634c|M.abscessus_ATCC_199 AVARVWTKAFWRPRSDAPEGD----------LAAAAPTALLD--------
MMAR_1470|M.marinum_M FYVRVIVLMFFT---EESSDT----------PQVVAPGILSK--------
MUL_2472|M.ulcerans_Agy99 FYVRVIVLMFFT---EESSDT----------PQVVAPGILSK--------
MAV_4047|M.avium_104 FYVRVIVSMFFT---EATEDT----------PHVVAPGILSK--------
Rv0086|M.tuberculosis_H37Rv LARNSGRMLLGTPAAGAPAIT----------VPATAAAALMVG-------
Mb0086|M.bovis_AF2122/97 MTKAFGIGFLARPRSTQAEAAREAPASMRAGMAIAAGACLVLAVAPLLVA
: . * *
MSMEG_0846|M.smegmatis_MC2_155 -----------DGEDIEYADREGVGRMPIGMLIPTAALIVVGLVLTVAAG
TH_4005|M.thermoresistible__bu -----------DIEDIEFAERRHVGRMPVSMLVPTGGLILVGLALTIFAG
Mflv_0164|M.gilvum_PYR-GCK -----------ETMDIEHSDRDDVGRMPVGMLAPTGALIVVGLALTVLAG
Mvan_0742|M.vanbaalenii_PYR-1 -----------ETMDIELADRDDVGRMPVGMLAPTGALIVVGLLLTILAG
MAB_0634c|M.abscessus_ATCC_199 -----------DAEDVAFVDRADVGRIPAGMLAPTLGLIAVGVALTIFAG
MMAR_1470|M.marinum_M --------------------------------AAIAVCAAVTVLLGILPQ
MUL_2472|M.ulcerans_Agy99 --------------------------------AAIAVCAAVTVLLGILPQ
MAV_4047|M.avium_104 --------------------------------AAIAVCAAVTVALGVFPQ
Rv0086|M.tuberculosis_H37Rv --------------------------------------IVVSAALGITAG
Mb0086|M.bovis_AF2122/97 PMVRRAAATLPAAQAVKFTGLGAVVRLPAMSGSIAPGVIAAAVLAAALAV
. .
MSMEG_0846|M.smegmatis_MC2_155 PIFA--------------FSERAAAEVIDRGQYITAVLGETR--------
TH_4005|M.thermoresistible__bu PIVA--------------YSERAAEQVLDRGRYIGAVIGEAP--------
Mflv_0164|M.gilvum_PYR-GCK PIIA--------------YSDRAAAEVLDRSQYIGAVLGGQP--------
Mvan_0742|M.vanbaalenii_PYR-1 PIFG--------------YSDRAAGEVIDRGQYIGAVLGGTR--------
MAB_0634c|M.abscessus_ATCC_199 PIIA--------------ISDRAAAEVRDRTVYISAVLGGAPR-------
MMAR_1470|M.marinum_M PVLD--------------LANQAAHLLH----------------------
MUL_2472|M.ulcerans_Agy99 PVLD--------------LANQAAHLLH----------------------
MAV_4047|M.avium_104 PLLD--------------LADQAAQLLH----------------------
Rv0086|M.tuberculosis_H37Rv PLAD--------------LLGIAASNVGLP--------------------
Mb0086|M.bovis_AF2122/97 AVLARWRFRRRPAPARLPLWACGAADLTVRMQYTATSFAEPLQRVFGDVL
.: .* :
MSMEG_0846|M.smegmatis_MC2_155 --------------------------------------------------
TH_4005|M.thermoresistible__bu --------------------------------------------------
Mflv_0164|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0742|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_0634c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_1470|M.marinum_M --------------------------------------------------
MUL_2472|M.ulcerans_Agy99 --------------------------------------------------
MAV_4047|M.avium_104 --------------------------------------------------
Rv0086|M.tuberculosis_H37Rv --------------------------------------------------
Mb0086|M.bovis_AF2122/97 RPDTDIEVTHTAESRYMAERITYRTAVADAIEQRLYTPVVGAVAAMAELL
MSMEG_0846|M.smegmatis_MC2_155 -----------------------------
TH_4005|M.thermoresistible__bu -----------------------------
Mflv_0164|M.gilvum_PYR-GCK -----------------------------
Mvan_0742|M.vanbaalenii_PYR-1 -----------------------------
MAB_0634c|M.abscessus_ATCC_199 -----------------------------
MMAR_1470|M.marinum_M -----------------------------
MUL_2472|M.ulcerans_Agy99 -----------------------------
MAV_4047|M.avium_104 -----------------------------
Rv0086|M.tuberculosis_H37Rv -----------------------------
Mb0086|M.bovis_AF2122/97 RRAHTGSVHRYLAYGALGVLIVLVVARCT