For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
STMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVCTALLYLTDRDGTFALAVGGWGPTE EKLGPLGITLVVDRLSALMLVVSAIVLLAVVLYAAAQGIRDGDERQPVSIFMPTYLALSAGVCNAFLAGD LFNLYVGFEVLLAASFVLLTIGASADRVRAGISYVMVSMMSSVVFLLGIAFVYAATGTLNMAEIALRADG IPSGTRMAIFAVLLVGFAIKAAVFPLSTWLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGGL NTVLLVAALLTMIVGILGAIAQSDIKRLLSFTLVSHIGYMIFGIALSNELGMSGAIYYVAHHIIVQTTLF LVVGLIERQAGASSLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKVALLEAGSLQGSVLAWALV AGGTITSLLTLYAVARVWTKAFWRPRSDAPEGDLAAAAPTALLDDAEDVAFVDRADVGRIPAGMLAPTLG LIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0634c | - | - | 100% (533) | putative monovalent cation/H+ antiporter subunit D |
| M. abscessus ATCC 19977 | MAB_2147 | - | 5e-40 | 29.40% (483) | NADH dehydrogenase subunit N |
| M. abscessus ATCC 19977 | MAB_2146 | - | 4e-36 | 28.57% (378) | NADH dehydrogenase subunit M |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0089 | hycQ | 4e-43 | 28.74% (515) | hydrogenase HycQ |
| M. gilvum PYR-GCK | Mflv_0164 | - | 0.0 | 80.79% (531) | putative monovalent cation/H+ antiporter subunit D |
| M. tuberculosis H37Rv | Rv0086 | hycQ | 2e-43 | 28.93% (515) | hydrogenase HycQ |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_1471 | nuoM | 6e-36 | 28.15% (373) | NADH dehydrogenase I (chain M) NuoM (NADH- ubiquinone |
| M. avium 104 | MAV_4047 | - | 2e-39 | 30.81% (396) | NADH dehydrogenase subunit N |
| M. smegmatis MC2 155 | MSMEG_0846 | - | 0.0 | 78.71% (526) | putative monovalent cation/H+ antiporter subunit D |
| M. thermoresistible (build 8) | TH_4005 | - | 0.0 | 77.07% (532) | PUTATIVE NADH-ubiquinone oxidoreductase/multisubunit na+/h+ |
| M. ulcerans Agy99 | MUL_2471 | nuoM | 1e-36 | 27.07% (447) | NADH dehydrogenase subunit M |
| M. vanbaalenii PYR-1 | Mvan_0742 | - | 0.0 | 81.29% (529) | putative monovalent cation/H+ antiporter subunit D |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0089|M.bovis_AF2122/97 --------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALSATTVLA
Rv0086|M.tuberculosis_H37Rv --------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALSATTVLA
MSMEG_0846|M.smegmatis_MC2_155 ------MMVQTLIPLPVLIPTLAAAATLIAGRRPHLQRAIAQIALTAVVA
TH_4005|M.thermoresistible__bu -----MNLAATLTPLPVLIPTLSAAATLIAGRRVRLQRMIALLSLTAMVA
Mflv_0164|M.gilvum_PYR-GCK --MIGAHLASVLTPLPVLIPMLGAAATLIAGRRPRLQRAIVVSGLSAVVA
Mvan_0742|M.vanbaalenii_PYR-1 --MIGAQFASVLTPLPVLVPMLAAAATLIAGRRPRLQRSIVVLALSTVVA
MAB_0634c|M.abscessus_ATCC_199 -----MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLG
MMAR_1471|M.marinum_M --------MNSHVPWLTLLWLVPLAASVLIILLPPGLRQLAKWTGLIASV
MUL_2471|M.ulcerans_Agy99 -------MVNSHVPWLTLLWLVPLAASVLTILLPPGLRQLAKWTGLIASV
MAV_4047|M.avium_104 MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGG
* :: .
Mb0089|M.bovis_AF2122/97 CAVAMGFWMGSGAQF-----GLGG--------LLRADALTVVMLVVIGIV
Rv0086|M.tuberculosis_H37Rv CAVAMGFWMGSGAQF-----GLGG--------LLRADALTVVMLVVIGIV
MSMEG_0846|M.smegmatis_MC2_155 VCGVLLYLSDRDGTL-----VLHVGGWDQAIPGMGPLGITLVVDRLSALM
TH_4005|M.thermoresistible__bu VCAVLLYLTDRDGTV-----VVHVGGWGEIVGGLGPLGITLVVDRLAAMM
Mflv_0164|M.gilvum_PYR-GCK VSAALLYLADRDGTI-----ALQVGGWGPTEDGLGPLGVTLVVDRLSALM
Mvan_0742|M.vanbaalenii_PYR-1 VSAALLYLADRDGTF-----ALQVGGWGSTEAGMGPLGVTLVVDRLSALM
MAB_0634c|M.abscessus_ATCC_199 VCTALLYLTDRDGTF-----ALAVGGWGPTEEKLGPLGITLVVDRLSALM
MMAR_1471|M.marinum_M VTLAVSVVVATGFKP-----SGEHYQFVENRSWIPAFGASYTLG-VDGIA
MUL_2471|M.ulcerans_Agy99 VTLAMSVVVATGFKP-----SGEHYQFVENRSWIPAFGASYTLG-VDGIA
MAV_4047|M.avium_104 LVAALFAVIEVAESLPASGRAAVLGAMAIDRPTLYLQGTVLLVAVMAVIF
.: : . : : :
Mb0089|M.bovis_AF2122/97 GTLATAASIGYIDTELAHG-------------------HIDGRSARLYGV
Rv0086|M.tuberculosis_H37Rv GTLATAASIGYIDTELAHG-------------------HIDGRSARLYGV
MSMEG_0846|M.smegmatis_MC2_155 LVVSSIVLLAVVVYAIGQG-------------------IRDGDERQPVSI
TH_4005|M.thermoresistible__bu LVVSSIVLLAVVQYAIGQG-------------------VRDGDERQPVSI
Mflv_0164|M.gilvum_PYR-GCK LVVSSIVLLAVVFYAIGQG-------------------IRDGDERQPVSI
Mvan_0742|M.vanbaalenii_PYR-1 LVVSSIVLLAVVFYAIGQG-------------------IRDGDERQPVSI
MAB_0634c|M.abscessus_ATCC_199 LVVSAIVLLAVVLYAAAQG-------------------IRDGDERQPVSI
MMAR_1471|M.marinum_M VVLVLLTTVLIPLLQIAGW-------------------NDGGERTRGVHA
MUL_2471|M.ulcerans_Agy99 VVLVLLTTVLIPLLQIAGW-------------------NDGGERTRGVHA
MAV_4047|M.avium_104 IAERTQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERAGAAQTE
. . .
Mb0089|M.bovis_AF2122/97 LTPAFLCATV---LAVCANNIGVIWVAIEATTVITAFLVG-HRRTRTA-L
Rv0086|M.tuberculosis_H37Rv LTPAFLCAMV---LAVCANNIGVIWVAIEATTVITAFLVG-HRRTRTA-L
MSMEG_0846|M.smegmatis_MC2_155 FMPTYLVLSAGVYTAFLAGDLFNLFVGFEVLLAASFVLLT-IGASADR-V
TH_4005|M.thermoresistible__bu FIPTYLVLSAGVCMAFVAGDLFNLFVGFEVLLTASFVLLT-IGASEER-V
Mflv_0164|M.gilvum_PYR-GCK FLPTYLVLSAGVFMAFLAGDLFNLFVGFEVLLTASFVLLT-IGASKER-V
Mvan_0742|M.vanbaalenii_PYR-1 FLPTYLVLSAGVFMAFLAGDLFNLFVGFEVLLTASFVLLT-IGASKER-V
MAB_0634c|M.abscessus_ATCC_199 FMPTYLALSAGVCNAFLAGDLFNLYVGFEVLLAASFVLLT-IGASADR-V
MMAR_1471|M.marinum_M YVALTLAIESMVLISVVALDVLLFYVFFEAMLIPMYFLIGGFGQGRAR-S
MUL_2471|M.ulcerans_Agy99 YVALTLAIESMVLISVVALDVLLFYVFFEAMLIPMYFLIGGFGQGRAR-S
MAV_4047|M.avium_104 LFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARHRRLLSQ
. : : :: ::* :*. .:
Mb0089|M.bovis_AF2122/97 EATWKYVVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAG
Rv0086|M.tuberculosis_H37Rv EATWKYVVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHAAG
MSMEG_0846|M.smegmatis_MC2_155 RAGISYVLVSMVSSMIFLIGIALVYAST--------GTLNLAELGVRLTD
TH_4005|M.thermoresistible__bu RAGTYYVMVSMVSSLIFLAGIGLVYAAT--------GTLNMAELAVRLDD
Mflv_0164|M.gilvum_PYR-GCK RAGISYVMVSMVSSLVFLFGIALVYATT--------GTLNLAEIAVRLDD
Mvan_0742|M.vanbaalenii_PYR-1 RAGISYVMVSMVSSLVFLFGIALVYATT--------GTLNLAEIAVRLDD
MAB_0634c|M.abscessus_ATCC_199 RAGISYVMVSMMSSVVFLLGIAFVYAAT--------GTLNMAEIALRADG
MMAR_1471|M.marinum_M GAAVKFLLYNLFGGLIMLAAVIGLYVVTAQNGS---GTFDFRDIVAGVQG
MUL_2471|M.ulcerans_Agy99 GAAVKFLLYNLFGGLIMLAAVIGLYVVTAQNGS---GTFDFRDIVAGVQG
MAV_4047|M.avium_104 EAAMKYFLLGAFSSAFFLYGVALLYGAT--------GTLLLTGIRDALIT
* :.: .. . : . :* : *:: : :
Mb0089|M.bovis_AF2122/97 ----LDPGVARLAGGLLLIGYGAKAGLFPFHTWLADAHSQAPAPVSALMS
Rv0086|M.tuberculosis_H37Rv ----LDPGVARLAGGLLLIGYGAKAGLFPFHTWLADAHSQAPAPVSALMS
MSMEG_0846|M.smegmatis_MC2_155 ----LPPGTRTAIFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFA
TH_4005|M.thermoresistible__bu ----IAPGTRTALFAVLLIAFGIKAAVFPLSSWLPDSYPTAPAPVTAVFA
Mflv_0164|M.gilvum_PYR-GCK ----VPEGTRMALFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFA
Mvan_0742|M.vanbaalenii_PYR-1 ----VPEGTRMALFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFA
MAB_0634c|M.abscessus_ATCC_199 ----IPSGTRMAIFAVLLVGFAIKAAVFPLSTWLPDSYPTAPAPVTAVFA
MMAR_1471|M.marinum_M GHYGEHPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAAVESTPATAVLMM
MUL_2471|M.ulcerans_Agy99 GHYGEHPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAAVESTPATAVLMM
MAV_4047|M.avium_104 R---GDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMA
. : .. *. *: *:.* :... : .:
Mb0089|M.bovis_AF2122/97 GVLLAVAFSVLIRLRPILDAVSGPAYLRNGLLVVGLATLLVAVLMLTVTG
Rv0086|M.tuberculosis_H37Rv GVLLAVAFSVLIRLRPILDAVSGPAYLRNGLLVVGLATLLVAVLMLTVTG
MSMEG_0846|M.smegmatis_MC2_155 GLLTKVGVYAIIRAHSLLFPDGG---LDSVLLVAGLLTMVIGILGAIAQS
TH_4005|M.thermoresistible__bu GLLTKVGVYAIIRTHSLLFPGAG---LDPLLLIAALATMLIGILGAIAQS
Mflv_0164|M.gilvum_PYR-GCK GLLTKVGVYAIIRAHSLLFPGGG---MDRILLVAGLLTMVIGIFGAIAQS
Mvan_0742|M.vanbaalenii_PYR-1 GLLTKVGVYAIIRAHSLLFPGGG---MDRVLLVAGLLTMIIGIFGAIAQS
MAB_0634c|M.abscessus_ATCC_199 GLLTKVGVYAIIRAHSLLFPGGG---LNTVLLVAALLTMIVGILGAIAQS
MMAR_1471|M.marinum_M AVMDKVGTFGMLRYCLQLFPDAS-TYFRPLIVTLAIIGVIYGAVVAIGQT
MUL_2471|M.ulcerans_Agy99 AVMDKVGTFGMLRYCLQLFPDAS-TYFRPLIVTLAIIGVIYGAVVAIGQT
MAV_4047|M.avium_104 AATKVAAFGALLRVVYVALPPLH-DQWRPVLWTISILTMAVGTITAVNQS
. .. ::* . : .: : . .
Mb0089|M.bovis_AF2122/97 DVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHGIGKTVLFLAG
Rv0086|M.tuberculosis_H37Rv DVKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHGIGKTVLFLAG
MSMEG_0846|M.smegmatis_MC2_155 DIKRLLSFTLVSHIGYMVFGIALGNELGMAGAIYYVAHHIVVQTTLFLVV
TH_4005|M.thermoresistible__bu DIKRLLSFTLVSHIGYMVFGIALSTQLGMSGAIYYVAHHIVVQTTLFLVV
Mflv_0164|M.gilvum_PYR-GCK DIKRLLSFTLVSHIGYMVFGIALSTQLGMAGAIYYVAHHILVQTTLFLVV
Mvan_0742|M.vanbaalenii_PYR-1 DIKRLLSFTLVSHIGYMVFGIALSTHLGMSGAIYYVAHHILVQTTLFLVV
MAB_0634c|M.abscessus_ATCC_199 DIKRLLSFTLVSHIGYMIFGIALSNELGMSGAIYYVAHHIIVQTTLFLVV
MMAR_1471|M.marinum_M DIMRLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIA
MUL_2471|M.ulcerans_Agy99 DIMRLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIA
MAV_4047|M.avium_104 DVKRMLAYSSVAHVGFILTGVIADNHTGLSATLFYLLAYSFSTVGAFAIV
*: *::::: : *.* : . . . :. :: : . . *
Mb0089|M.bovis_AF2122/97 GQLQAAHDST--AIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASE
Rv0086|M.tuberculosis_H37Rv GQLQAAHDST--AIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASE
MSMEG_0846|M.smegmatis_MC2_155 GLIERQAGAS--TLQRLGGLAAASPVLAFVWVVPALNLGGIPPFSGFIGK
TH_4005|M.thermoresistible__bu GLIERQAGAS--TLQRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGK
Mflv_0164|M.gilvum_PYR-GCK GLIERQAGAS--TLERLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGK
Mvan_0742|M.vanbaalenii_PYR-1 GLIERQAGAS--TLERLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGK
MAB_0634c|M.abscessus_ATCC_199 GLIERQAGAS--SLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGK
MMAR_1471|M.marinum_M GFLISRHGSR--AIADYGGVQKVAPVLAGTFLVSAMATLSLPGLAPFISE
MUL_2471|M.ulcerans_Agy99 GFLISRHGSR--AIADYGGVQKVAPVLAGTFLVSAMATLSLPGLAPFISE
MAV_4047|M.avium_104 GLIRDADGVEDATLSHWAGLGQRSPIVGVMFSMFLLAFAGIPLTSGFVSK
* : . :: *: : ::. : : : .:* : * .:
Mb0089|M.bovis_AF2122/97 LAIARS--LANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPA
Rv0086|M.tuberculosis_H37Rv LAIARS--LANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPA
MSMEG_0846|M.smegmatis_MC2_155 IALMEAGAANGSALAWTLVAGGVVTSLLTLYVVARVWTKAFWRTRADAPE
TH_4005|M.thermoresistible__bu VALMEAGAADGSVLAWTLVGGSVVTSLLTLYVVARVWTKAFWRSRADAPE
Mflv_0164|M.gilvum_PYR-GCK VALLEAGAESGSVLAWILVAGSVITSLLTLYVVARVWTKAFWRARKDAPE
Mvan_0742|M.vanbaalenii_PYR-1 VALLEAGAQSGSVLAWALVAGSVATSLLTLYVVARVWTKAFWRSRKDAPE
MAB_0634c|M.abscessus_ATCC_199 VALLEAGSLQGSVLAWALVAGGTITSLLTLYAVARVWTKAFWRPRSDAPE
MMAR_1471|M.marinum_M FLVLLGTFNRYWLAAAFGVTALVLSAIYMLWLYQRVMTGPLAKGNERIGD
MUL_2471|M.ulcerans_Agy99 FLVLLGTFNRYWLAAALGVTALVLSAIYMLWLYQRVMTGPLAKGNERIGD
MAV_4047|M.avium_104 LAVFKAAAQGGAVP--LVIVGVVASGVAAYFYVRVIVSMFFTEATEDTPH
. : . . .: :
Mb0089|M.bovis_AF2122/97 ITVPATAAAALMVG-----------------------------IVVSAAL
Rv0086|M.tuberculosis_H37Rv ITVPATAAAALMVG-----------------------------IVVSAAL
MSMEG_0846|M.smegmatis_MC2_155 GHLSQAAPAVLLD---DGEDIEYADREGVGRMPIGMLIPTAALIVVGLVL
TH_4005|M.thermoresistible__bu GHLSAAAPAVLLD---DIEDIEFAERRHVGRMPVSMLVPTGGLILVGLAL
Mflv_0164|M.gilvum_PYR-GCK GHLSGPAPTALLDNTDETMDIEHSDRDDVGRMPVGMLAPTGALIVVGLAL
Mvan_0742|M.vanbaalenii_PYR-1 GHLSGPAPAALLDNTDETMDIELADRDDVGRMPVGMLAPTGALIVVGLLL
MAB_0634c|M.abscessus_ATCC_199 GDLAAAAPTALLD---DAEDVAFVDRADVGRIPAGMLAPTLGLIAVGVAL
MMAR_1471|M.marinum_M LVPREMIVVAPLIA----------------MLLILGVYPKPVLDVINPAV
MUL_2471|M.ulcerans_Agy99 LVPREMIVVAPLIA----------------MLLILGVYPKPVLDVINPAV
MAV_4047|M.avium_104 VVAPGILSKAAIAV----------------------------CAAVTVAL
. : : :
Mb0089|M.bovis_AF2122/97 GITAGPLADLLGIAASNVGLP-------------
Rv0086|M.tuberculosis_H37Rv GITAGPLADLLGIAASNVGLP-------------
MSMEG_0846|M.smegmatis_MC2_155 TVAAGPIFAFSERAAAEVIDRGQYITAVLGETR-
TH_4005|M.thermoresistible__bu TIFAGPIVAYSERAAEQVLDRGRYIGAVIGEAP-
Mflv_0164|M.gilvum_PYR-GCK TVLAGPIIAYSDRAAAEVLDRSQYIGAVLGGQP-
Mvan_0742|M.vanbaalenii_PYR-1 TILAGPIFGYSDRAAGEVIDRGQYIGAVLGGTR-
MAB_0634c|M.abscessus_ATCC_199 TIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR
MMAR_1471|M.marinum_M EHTMSTIGQHDPAPKVPHPVSGVSAPRTAEGPHE
MUL_2471|M.ulcerans_Agy99 EHTMSTIGQHDPAPKVPHPVSGVSAPRTAEGPHE
MAV_4047|M.avium_104 GVFPQPLLDLADQAAQLLH---------------
.: .