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IGAQFASVLTPLPVLVPMLAAAATLIAGRRPRLQRSIVVLALSTVVAVSAALLYLADRDGTFALQVGGWG STEAGMGPLGVTLVVDRLSALMLVVSSIVLLAVVFYAIGQGIRDGDERQPVSIFLPTYLVLSAGVFMAFL AGDLFNLFVGFEVLLTASFVLLTIGASKERVRAGISYVMVSMVSSLVFLFGIALVYATTGTLNLAEIAVR LDDVPEGTRMALFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPG GGMDRVLLVAGLLTMIIGIFGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTHLGMSGAIYYVAHHILVQT TLFLVVGLIERQAGASTLERLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKVALLEAGAQSGSVLAW ALVAGSVATSLLTLYVVARVWTKAFWRSRKDAPEGHLSGPAPAALLDNTDETMDIELADRDDVGRMPVGM LAPTGALIVVGLLLTILAGPIFGYSDRAAGEVIDRGQYIGAVLGGTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0742 | - | - | 100% (538) | putative monovalent cation/H+ antiporter subunit D |
| M. vanbaalenii PYR-1 | Mvan_1872 | - | 1e-40 | 28.00% (475) | NADH dehydrogenase subunit N |
| M. vanbaalenii PYR-1 | Mvan_1873 | - | 9e-37 | 25.10% (514) | NADH dehydrogenase subunit M |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0089 | hycQ | 1e-38 | 27.74% (429) | hydrogenase HycQ |
| M. gilvum PYR-GCK | Mflv_0164 | - | 0.0 | 94.40% (536) | putative monovalent cation/H+ antiporter subunit D |
| M. tuberculosis H37Rv | Rv0086 | hycQ | 8e-39 | 27.74% (429) | hydrogenase HycQ |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0634c | - | 0.0 | 81.29% (529) | putative monovalent cation/H+ antiporter subunit D |
| M. marinum M | MMAR_1470 | nuoN | 3e-36 | 29.46% (336) | NADH dehydrogenase I (chain N) NuoN (NADH- ubiquinone |
| M. avium 104 | MAV_4047 | - | 1e-41 | 32.46% (342) | NADH dehydrogenase subunit N |
| M. smegmatis MC2 155 | MSMEG_0846 | - | 0.0 | 83.18% (529) | putative monovalent cation/H+ antiporter subunit D |
| M. thermoresistible (build 8) | TH_4005 | - | 0.0 | 82.04% (529) | PUTATIVE NADH-ubiquinone oxidoreductase/multisubunit na+/h+ |
| M. ulcerans Agy99 | MUL_2472 | nuoN | 1e-35 | 29.46% (336) | NADH dehydrogenase subunit N |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0089|M.bovis_AF2122/97 --------------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALS
Rv0086|M.tuberculosis_H37Rv --------------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALS
Mvan_0742|M.vanbaalenii_PYR-1 --------MIGAQFASVLTPLPVLVPMLAAAATLIAGRRPRLQRSIVVLA
Mflv_0164|M.gilvum_PYR-GCK --------MIGAHLASVLTPLPVLIPMLGAAATLIAGRRPRLQRAIVVSG
MSMEG_0846|M.smegmatis_MC2_155 ------------MMVQTLIPLPVLIPTLAAAATLIAGRRPHLQRAIAQIA
TH_4005|M.thermoresistible__bu -----------MNLAATLTPLPVLIPTLSAAATLIAGRRVRLQRMIALLS
MAB_0634c|M.abscessus_ATCC_199 -----------MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTA
MMAR_1470|M.marinum_M -MILPSPSIEYFLLCPMLIVFGIAVIGVLAEAFLPRRLRYGAQVTLALSG
MUL_2472|M.ulcerans_Agy99 -MILPSPSIEYFLLCPMLIVFGIAVVGVLAEAFLPRRLRYGAQVTLALSG
MAV_4047|M.avium_104 MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLALGG
* : : * * :. .
Mb0089|M.bovis_AF2122/97 ATTVLACAVAMGFWMGSGAQFGLGG--------LLRADALTVVMLVVIGI
Rv0086|M.tuberculosis_H37Rv ATTVLACAVAMGFWMGSGAQFGLGG--------LLRADALTVVMLVVIGI
Mvan_0742|M.vanbaalenii_PYR-1 LSTVVAVSAALLYLADRDGTFALQVGGWGSTEAGMGPLGVTLVVDRLSAL
Mflv_0164|M.gilvum_PYR-GCK LSAVVAVSAALLYLADRDGTIALQVGGWGPTEDGLGPLGVTLVVDRLSAL
MSMEG_0846|M.smegmatis_MC2_155 LTAVVAVCGVLLYLSDRDGTLVLHVGGWDQAIPGMGPLGITLVVDRLSAL
TH_4005|M.thermoresistible__bu LTAMVAVCAVLLYLTDRDGTVVVHVGGWGEIVGGLGPLGITLVVDRLAAM
MAB_0634c|M.abscessus_ATCC_199 LTTVLGVCTALLYLTDRDGTFALAVGGWGPTEEKLGPLGITLVVDRLSAL
MMAR_1470|M.marinum_M LVAAFVAVIVVARSIPVTGRRAVLGSMAVDRPTLFLQGTVLLVAVMAVIF
MUL_2472|M.ulcerans_Agy99 LVAAFVAVIVVARSIPVTGRRAVLGSMAVDRPTLFLQGTVLLVEVMAVIF
MAV_4047|M.avium_104 LVAALFAVIEVAESLPASGRAAVLGAMAIDRPTLYLQGTVLLVAVMAVIF
: . : . : : :* :
Mb0089|M.bovis_AF2122/97 VGTLATAASIGYIDTELAHGHIDGRSARLYGVLTP---------------
Rv0086|M.tuberculosis_H37Rv VGTLATAASIGYIDTELAHGHIDGRSARLYGVLTP---------------
Mvan_0742|M.vanbaalenii_PYR-1 MLVVSSIVLLAVVFYAIGQGIRDGDERQPVSIFLP---------------
Mflv_0164|M.gilvum_PYR-GCK MLVVSSIVLLAVVFYAIGQGIRDGDERQPVSIFLP---------------
MSMEG_0846|M.smegmatis_MC2_155 MLVVSSIVLLAVVVYAIGQGIRDGDERQPVSIFMP---------------
TH_4005|M.thermoresistible__bu MLVVSSIVLLAVVQYAIGQGVRDGDERQPVSIFIP---------------
MAB_0634c|M.abscessus_ATCC_199 MLVVSAIVLLAVVLYAAAQGIRDGDERQPVSIFMP---------------
MMAR_1470|M.marinum_M IAERSAHRVAAQTKTAVAAGSGGLDSFTPQASAVPGSDAEREAQRAGAAQ
MUL_2472|M.ulcerans_Agy99 IAERSAHRVAAQTKTAVAAGSGGLDSFTPQASAVPGSDAEREAQRAGVAQ
MAV_4047|M.avium_104 IAER--TQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERAGAAQ
: . * . . . *
Mb0089|M.bovis_AF2122/97 ----AFLCATV---LAVCAN-NIGVIWVAIEATTVITAFLVGHRRTRTAL
Rv0086|M.tuberculosis_H37Rv ----AFLCAMV---LAVCAN-NIGVIWVAIEATTVITAFLVGHRRTRTAL
Mvan_0742|M.vanbaalenii_PYR-1 ----TYLVLSAGVFMAFLAG-DLFNLFVGFEVLLTASFVLLTIGASKERV
Mflv_0164|M.gilvum_PYR-GCK ----TYLVLSAGVFMAFLAG-DLFNLFVGFEVLLTASFVLLTIGASKERV
MSMEG_0846|M.smegmatis_MC2_155 ----TYLVLSAGVYTAFLAG-DLFNLFVGFEVLLAASFVLLTIGASADRV
TH_4005|M.thermoresistible__bu ----TYLVLSAGVCMAFVAG-DLFNLFVGFEVLLTASFVLLTIGASEERV
MAB_0634c|M.abscessus_ATCC_199 ----TYLALSAGVCNAFLAG-DLFNLYVGFEVLLAASFVLLTIGASADRV
MMAR_1470|M.marinum_M TEIFPLLTLSVGGMMVFPAANDLLTMFVALEVLSLPLYLMCGLARHRRLL
MUL_2472|M.ulcerans_Agy99 TEIFPLLTLSVGGMMVFPAANDLLTMFVALEVLSLPLYLMCGLARHRRLL
MAV_4047|M.avium_104 TELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARHRRLL
. . .. * :: ::*.:*. .: :
Mb0089|M.bovis_AF2122/97 E--ATWKYVVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHA
Rv0086|M.tuberculosis_H37Rv E--ATWKYVVICSVGIAVAFLGTVLLYFAARDSGAAAAGALNLDILAEHA
Mvan_0742|M.vanbaalenii_PYR-1 R--AGISYVMVSMVSSLVFLFGIALVYATT--------GTLNLAEIAVRL
Mflv_0164|M.gilvum_PYR-GCK R--AGISYVMVSMVSSLVFLFGIALVYATT--------GTLNLAEIAVRL
MSMEG_0846|M.smegmatis_MC2_155 R--AGISYVLVSMVSSMIFLIGIALVYAST--------GTLNLAELGVRL
TH_4005|M.thermoresistible__bu R--AGTYYVMVSMVSSLIFLAGIGLVYAAT--------GTLNMAELAVRL
MAB_0634c|M.abscessus_ATCC_199 R--AGISYVMVSMMSSVVFLLGIAFVYAAT--------GTLNMAEIALRA
MMAR_1470|M.marinum_M SQESALKYFLLGAFSSAFFLYGVALLYGAT--------GSLTLTGIRDSL
MUL_2472|M.ulcerans_Agy99 SQESALKYFLLGAFSSAVFLYGVALLYGAT--------DSLTLTGIRDSL
MAV_4047|M.avium_104 SQEAAMKYFLLGAFSSAFFLYGVALLYGAT--------GTLLLTGIRDAL
: *.:: .. . : * ::* :: .:* : :
Mb0089|M.bovis_AF2122/97 AG-LDPGVARLAGGLLLIGYGAKAGLFPFHTWLADAHSQAPAPVSALMSG
Rv0086|M.tuberculosis_H37Rv AG-LDPGVARLAGGLLLIGYGAKAGLFPFHTWLADAHSQAPAPVSALMSG
Mvan_0742|M.vanbaalenii_PYR-1 DD-VPEGTRMALFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFAG
Mflv_0164|M.gilvum_PYR-GCK DD-VPEGTRMALFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFAG
MSMEG_0846|M.smegmatis_MC2_155 TD-LPPGTRTAIFAVLLVAFGIKAAVFPLSAWLPDSYPTAPAPVTAVFAG
TH_4005|M.thermoresistible__bu DD-IAPGTRTALFAVLLIAFGIKAAVFPLSSWLPDSYPTAPAPVTAVFAG
MAB_0634c|M.abscessus_ATCC_199 DG-IPSGTRMAIFAVLLVGFAIKAAVFPLSTWLPDSYPTAPAPVTAVFAG
MMAR_1470|M.marinum_M TARSDMSMALVGVGLLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAA
MUL_2472|M.ulcerans_Agy99 AARSDMSMALVGVGLLSVGLLFKVGAVPFHSWIPDVYQGAPTPTTGFMAA
MAV_4047|M.avium_104 ITRGDTSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAA
. .:* :. *.. .*: :*:.* : **:* :..::.
Mb0089|M.bovis_AF2122/97 VLLAVAFSVLIRLRPILDAVSGPAYLRNGLLVVGLATLLVAVLMLTVTGD
Rv0086|M.tuberculosis_H37Rv VLLAVAFSVLIRLRPILDAVSGPAYLRNGLLVVGLATLLVAVLMLTVTGD
Mvan_0742|M.vanbaalenii_PYR-1 LLTKVGVYAIIRAHSLLFPGGG---MDRVLLVAGLLTMIIGIFGAIAQSD
Mflv_0164|M.gilvum_PYR-GCK LLTKVGVYAIIRAHSLLFPGGG---MDRILLVAGLLTMVIGIFGAIAQSD
MSMEG_0846|M.smegmatis_MC2_155 LLTKVGVYAIIRAHSLLFPDGG---LDSVLLVAGLLTMVIGILGAIAQSD
TH_4005|M.thermoresistible__bu LLTKVGVYAIIRTHSLLFPGAG---LDPLLLIAALATMLIGILGAIAQSD
MAB_0634c|M.abscessus_ATCC_199 LLTKVGVYAIIRAHSLLFPGGG---LNTVLLVAALLTMIVGILGAIAQSD
MMAR_1470|M.marinum_M ATKVAAFGALLRVVYVALPPLHD-QWRPVLWAISILTMAVGTITAVNQTN
MUL_2472|M.ulcerans_Agy99 ATKVAAFGALLRVVYVALPPLHD-QWRPVLWAISILTMAVGTITAVNQTN
MAV_4047|M.avium_104 ATKVAAFGALLRVVYVALPPLHD-QWRPVLWTISILTMAVGTITAVNQSD
... .::* : . * .: *: :. : :
Mb0089|M.bovis_AF2122/97 VKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHGIGKTVLFLAGG
Rv0086|M.tuberculosis_H37Rv VKRMLAYSSMEHMGLIAIAAAAGTTLAIAALLLHVLAHGIGKTVLFLAGG
Mvan_0742|M.vanbaalenii_PYR-1 IKRLLSFTLVSHIGYMVFGIALSTHLGMSGAIYYVAHHILVQTTLFLVVG
Mflv_0164|M.gilvum_PYR-GCK IKRLLSFTLVSHIGYMVFGIALSTQLGMAGAIYYVAHHILVQTTLFLVVG
MSMEG_0846|M.smegmatis_MC2_155 IKRLLSFTLVSHIGYMVFGIALGNELGMAGAIYYVAHHIVVQTTLFLVVG
TH_4005|M.thermoresistible__bu IKRLLSFTLVSHIGYMVFGIALSTQLGMSGAIYYVAHHIVVQTTLFLVVG
MAB_0634c|M.abscessus_ATCC_199 IKRLLSFTLVSHIGYMIFGIALSNELGMSGAIYYVAHHIIVQTTLFLVVG
MMAR_1470|M.marinum_M VKRMLAYSSVAHVGFILTGVIADNSAGLSATLFYLVAYSFSTVGAFAIVG
MUL_2472|M.ulcerans_Agy99 VKRMLAYSSVAHVGFILTGVIADNSAGLSATLFYLVAYSFSTVGAFAIVG
MAV_4047|M.avium_104 VKRMLAYSSVAHVGFILTGVIADNHTGLSATLFYLLAYSFSTVGAFAIVG
:**:*::: : *:* : . .. .::. : :: : . . * *
Mb0089|M.bovis_AF2122/97 QLQAAHDST--AIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASEL
Rv0086|M.tuberculosis_H37Rv QLQAAHDST--AIADITGVMRRSRLIGVSFAVGLIVLLGLPPFAMFASEL
Mvan_0742|M.vanbaalenii_PYR-1 LIERQAGAS--TLERLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKV
Mflv_0164|M.gilvum_PYR-GCK LIERQAGAS--TLERLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKV
MSMEG_0846|M.smegmatis_MC2_155 LIERQAGAS--TLQRLGGLAAASPVLAFVWVVPALNLGGIPPFSGFIGKI
TH_4005|M.thermoresistible__bu LIERQAGAS--TLQRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKV
MAB_0634c|M.abscessus_ATCC_199 LIERQAGAS--SLNRLGGLAAASPLLAFVFVVPALNLGGIPPFSGFIGKV
MMAR_1470|M.marinum_M LVRDANGVEDANLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFISKF
MUL_2472|M.ulcerans_Agy99 LVRDADGVEDANLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFISKF
MAV_4047|M.avium_104 LIRDADGVEDATLSHWAGLGQRSPIVGVMFSMFLLAFAGIPLTSGFVSKL
:. . : *: * ::.. : : : *:* : * .:.
Mb0089|M.bovis_AF2122/97 AIARS--LANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAI
Rv0086|M.tuberculosis_H37Rv AIARS--LANERLAWVLGAALLLIAIGFTALARNSGRMLLGTPAAGAPAI
Mvan_0742|M.vanbaalenii_PYR-1 ALLEAGAQSGSVLAWALVAGSVATSLLTLYVVARVWTKAFWRSRKDAPEG
Mflv_0164|M.gilvum_PYR-GCK ALLEAGAESGSVLAWILVAGSVITSLLTLYVVARVWTKAFWRARKDAPEG
MSMEG_0846|M.smegmatis_MC2_155 ALMEAGAANGSALAWTLVAGGVVTSLLTLYVVARVWTKAFWRTRADAPEG
TH_4005|M.thermoresistible__bu ALMEAGAADGSVLAWTLVGGSVVTSLLTLYVVARVWTKAFWRSRADAPEG
MAB_0634c|M.abscessus_ATCC_199 ALLEAGSLQGSVLAWALVAGGTITSLLTLYAVARVWTKAFWRPRSDAPEG
MMAR_1470|M.marinum_M SVFKAAAEGGAAP--LVVIGVISSGVAAYFYVRVIVLMFFTEESSDTPQV
MUL_2472|M.ulcerans_Agy99 SVFKAAAEGGAAP--LVVIGVISSGVAAYFYVRVIVLMFFTEESSDTPQV
MAV_4047|M.avium_104 AVFKAAAQGGAVP--LVIVGVVASGVAAYFYVRVIVSMFFTEATEDTPHV
:: .: . : . .: . : .:*
Mb0089|M.bovis_AF2122/97 TVPATAAAALMVG-----------------------------IVVSAALG
Rv0086|M.tuberculosis_H37Rv TVPATAAAALMVG-----------------------------IVVSAALG
Mvan_0742|M.vanbaalenii_PYR-1 HLSGPAPAALLDNTDETMDIELADRDDVGRMPVGMLAPTGALIVVGLLLT
Mflv_0164|M.gilvum_PYR-GCK HLSGPAPTALLDNTDETMDIEHSDRDDVGRMPVGMLAPTGALIVVGLALT
MSMEG_0846|M.smegmatis_MC2_155 HLSQAAPAVLLD---DGEDIEYADREGVGRMPIGMLIPTAALIVVGLVLT
TH_4005|M.thermoresistible__bu HLSAAAPAVLLD---DIEDIEFAERRHVGRMPVSMLVPTGGLILVGLALT
MAB_0634c|M.abscessus_ATCC_199 DLAAAAPTALLD---DAEDVAFVDRADVGRIPAGMLAPTLGLIAVGVALT
MMAR_1470|M.marinum_M VAPGILSKAAIAVC----------------------------AAVTVLLG
MUL_2472|M.ulcerans_Agy99 VAPGILSKAAIAVC----------------------------AAVTVLLG
MAV_4047|M.avium_104 VAPGILSKAAIAVC----------------------------AAVTVALG
. . . : * *
Mb0089|M.bovis_AF2122/97 ITAGPLADLLGIAASNVGLP-------------
Rv0086|M.tuberculosis_H37Rv ITAGPLADLLGIAASNVGLP-------------
Mvan_0742|M.vanbaalenii_PYR-1 ILAGPIFGYSDRAAGEVIDRGQYIGAVLGGTR-
Mflv_0164|M.gilvum_PYR-GCK VLAGPIIAYSDRAAAEVLDRSQYIGAVLGGQP-
MSMEG_0846|M.smegmatis_MC2_155 VAAGPIFAFSERAAAEVIDRGQYITAVLGETR-
TH_4005|M.thermoresistible__bu IFAGPIVAYSERAAEQVLDRGRYIGAVIGEAP-
MAB_0634c|M.abscessus_ATCC_199 IFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR
MMAR_1470|M.marinum_M ILPQPVLDLANQAAHLLH---------------
MUL_2472|M.ulcerans_Agy99 ILPQPVLDLANQAAHLLH---------------
MAV_4047|M.avium_104 VFPQPLLDLADQAAQLLH---------------
: . *: ** :