For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TALLLAAILAPLAAAGAAAALGWRRLTSTVTVLSAATVLGCGAALSFTVGSQQYFVLGGLLRVDALCVTM LIVIGIVGTLATWASIGYIDAECADGHTDAGGARLYGALTPAFLAAMVVAVCANNIGVIWVAIEATTVIT AFLVGHRRTRTALEATWKYVIICSVGIAIAFLGTVLLYFAARHAGASAALALNLDVLGAHAHTLDPAVSR LAGGLLLIGYGAKAGLAPFHTWLADAHSQAPAPVSALMSGVLLSVAMSVLIRITPIVGAAAGPTFLRAGL LTVGLVTLFVAALMLTVTGDVKRMLAYSSMENMGLIAIAAAAGTTLAIAALLLHVLAHGVGKTVLFLAGG QLQAAHGSTAIADITGVVQRSHLIGGSFAVGLIVLLGLPPFAMFASELALAHALADARLAWVLGAAMLLI AIAFAALVRNASRMLLGPAAAAAPPITAPTTVTAALLVGVAASIVLGVTAGPLTDLFSTAAGQLGALR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5110 | - | - | 100% (489) | hydrogenase-4, F subunit, putative |
| M. avium 104 | MAV_5113 | - | 2e-36 | 29.38% (480) | NADH dehydrogenase subunit n |
| M. avium 104 | MAV_4047 | - | 2e-33 | 26.18% (489) | NADH dehydrogenase subunit N |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0089 | hycQ | 0.0 | 77.78% (486) | hydrogenase HycQ |
| M. gilvum PYR-GCK | Mflv_0164 | - | 8e-33 | 26.09% (437) | putative monovalent cation/H+ antiporter subunit D |
| M. tuberculosis H37Rv | Rv0086 | hycQ | 0.0 | 77.98% (486) | hydrogenase HycQ |
| M. leprae Br4923 | MLBr_00335 | - | 9e-05 | 26.53% (196) | putative ABC-transporter transmembrane protein |
| M. abscessus ATCC 19977 | MAB_0634c | - | 1e-35 | 26.78% (534) | putative monovalent cation/H+ antiporter subunit D |
| M. marinum M | MMAR_1658 | hycQ | 0.0 | 74.54% (487) | hydrogenase HycQ |
| M. smegmatis MC2 155 | MSMEG_0846 | - | 1e-33 | 25.90% (529) | putative monovalent cation/H+ antiporter subunit D |
| M. thermoresistible (build 8) | TH_4005 | - | 2e-32 | 26.89% (528) | PUTATIVE NADH-ubiquinone oxidoreductase/multisubunit na+/h+ |
| M. ulcerans Agy99 | MUL_1895 | hycQ | 0.0 | 74.13% (487) | hydrogenase HycQ |
| M. vanbaalenii PYR-1 | Mvan_0742 | - | 2e-35 | 26.33% (528) | putative monovalent cation/H+ antiporter subunit D |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0089|M.bovis_AF2122/97 ------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALSATTVLACA
Rv0086|M.tuberculosis_H37Rv ------MTGLLLAAILAPLAASIASLITGWR-RTTATLTALSATTVLACA
MAV_5110|M.avium_104 ------MTALLLAAILAPLAAAGAAAALGWR-RLTSTVTVLSAATVLGCG
MMAR_1658|M.marinum_M ------MTALILVPIVAPLVAAAFALAGGWR-RATAVLTVLSAVAVLGSG
MUL_1895|M.ulcerans_Agy99 ------MTALILVPIVAPLVAAAFALAGGWR-RATAVLTVLSAVAVLGSG
MSMEG_0846|M.smegmatis_MC2_155 ----MMVQTLIPLPVLIPTLAAAATLIAGRRPHLQRAIAQIALTAVVAVC
TH_4005|M.thermoresistible__bu ---MNLAATLTPLPVLIPTLSAAATLIAGRRVRLQRMIALLSLTAMVAVC
Mflv_0164|M.gilvum_PYR-GCK MIGAHLASVLTPLPVLIPMLGAAATLIAGRRPRLQRAIVVSGLSAVVAVS
Mvan_0742|M.vanbaalenii_PYR-1 MIGAQFASVLTPLPVLVPMLAAAATLIAGRRPRLQRSIVVLALSTVVAVS
MAB_0634c|M.abscessus_ATCC_199 ---MSTMSVLTPLPVLVPTTAAALTLIAGRRPRLQLLITVTALTTVLGVC
MLBr_00335|M.leprae_Br4923 -------------------MDDRLAHMWNHLFSFDITTHLLSHNFVQQAL
: . . :
Mb0089|M.bovis_AF2122/97 VAMGFWMGSGAQFGLG-----------GLLRADALTVVMLVVIGIVGTLA
Rv0086|M.tuberculosis_H37Rv VAMGFWMGSGAQFGLG-----------GLLRADALTVVMLVVIGIVGTLA
MAV_5110|M.avium_104 AALSFTVGSQQYFVLG-----------GLLRVDALCVTMLIVIGIVGTLA
MMAR_1658|M.marinum_M IALGLQATPQPHLVLG-----------GLLRVDALSVIMLIVIGAVGTLA
MUL_1895|M.ulcerans_Agy99 IALGLQATPQPHLVLG-----------GLLRVDALSVIMLIVIGAVGTLA
MSMEG_0846|M.smegmatis_MC2_155 GVLLYLSDRDGTLVLHVGGWDQAIPGMGPLGITLVVDRLSALMLVVSSIV
TH_4005|M.thermoresistible__bu AVLLYLTDRDGTVVVHVGGWGEIVGGLGPLGITLVVDRLAAMMLVVSSIV
Mflv_0164|M.gilvum_PYR-GCK AALLYLADRDGTIALQVGGWGPTEDGLGPLGVTLVVDRLSALMLVVSSIV
Mvan_0742|M.vanbaalenii_PYR-1 AALLYLADRDGTFALQVGGWGSTEAGMGPLGVTLVVDRLSALMLVVSSIV
MAB_0634c|M.abscessus_ATCC_199 TALLYLTDRDGTFALAVGGWGPTEEKLGPLGITLVVDRLSALMLVVSAIV
MLBr_00335|M.leprae_Br4923 LAALLLG---------------------------------LVAGLIGPFI
. : :..:
Mb0089|M.bovis_AF2122/97 TAASIGYIDTELAHGHIDGRSARLYGVLTPAFLCATVLAVCANNIGVIWV
Rv0086|M.tuberculosis_H37Rv TAASIGYIDTELAHGHIDGRSARLYGVLTPAFLCAMVLAVCANNIGVIWV
MAV_5110|M.avium_104 TWASIGYIDAECADGHTDAGGARLYGALTPAFLAAMVVAVCANNIGVIWV
MMAR_1658|M.marinum_M TWASIGYIDAELEHGHTDRRDARLYGALMPAFLAAMAIAVSANNIGLIWV
MUL_1895|M.ulcerans_Agy99 TWASIGYIDAELEHGHTDRRDARLYGALMPAFLAAMAIAVSANNIGLIWV
MSMEG_0846|M.smegmatis_MC2_155 LLAVVVYAIGQGIRDGDERQPVSIFMPTYLVLSAGVYTAFLAGDLFNLFV
TH_4005|M.thermoresistible__bu LLAVVQYAIGQGVRDGDERQPVSIFIPTYLVLSAGVCMAFVAGDLFNLFV
Mflv_0164|M.gilvum_PYR-GCK LLAVVFYAIGQGIRDGDERQPVSIFLPTYLVLSAGVFMAFLAGDLFNLFV
Mvan_0742|M.vanbaalenii_PYR-1 LLAVVFYAIGQGIRDGDERQPVSIFLPTYLVLSAGVFMAFLAGDLFNLFV
MAB_0634c|M.abscessus_ATCC_199 LLAVVLYAAAQGIRDGDERQPVSIFMPTYLALSAGVCNAFLAGDLFNLYV
MLBr_00335|M.leprae_Br4923 VMRQMSFAVHGSSE----------------LSLTGATFALLAG--FEMGV
: : . *. *. : *
Mb0089|M.bovis_AF2122/97 AIEATTVITAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
Rv0086|M.tuberculosis_H37Rv AIEATTVITAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
MAV_5110|M.avium_104 AIEATTVITAFLVGHRRTRTALEATWKYVIICSVGIAIAFLGTVLLYFAA
MMAR_1658|M.marinum_M AVEATTVVTAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
MUL_1895|M.ulcerans_Agy99 AVEATTVVTAFLVGHRRTRTALEATWKYVVICSVGIAVAFLGTVLLYFAA
MSMEG_0846|M.smegmatis_MC2_155 GFEVLLAASFVLLTIGASADRVRAGISYVLVSMVSSMIFLIGIALVYAST
TH_4005|M.thermoresistible__bu GFEVLLTASFVLLTIGASEERVRAGTYYVMVSMVSSLIFLAGIGLVYAAT
Mflv_0164|M.gilvum_PYR-GCK GFEVLLTASFVLLTIGASKERVRAGISYVMVSMVSSLVFLFGIALVYATT
Mvan_0742|M.vanbaalenii_PYR-1 GFEVLLTASFVLLTIGASKERVRAGISYVMVSMVSSLVFLFGIALVYATT
MAB_0634c|M.abscessus_ATCC_199 GFEVLLAASFVLLTIGASADRVRAGISYVMVSMMSSVVFLLGIAFVYAAT
MLBr_00335|M.leprae_Br4923 GALVGSALAATLFGILGRRARERDSVIGVVLAFG------LGLAVLFIHL
. . . : *. . *::. * .::
Mb0089|M.bovis_AF2122/97 RDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLLIGYGAKAGLFPFHT
Rv0086|M.tuberculosis_H37Rv RDSGAAAAGALNLDILAEHAAGLDPGVARLAGGLLLIGYGAKAGLFPFHT
MAV_5110|M.avium_104 RHAGASAALALNLDVLGAHAHTLDPAVSRLAGGLLLIGYGAKAGLAPFHT
MMAR_1658|M.marinum_M QHAGADGANALNLDVLTACAAHLNPAVTRLAGGLLLIGYGAKVGLAPFHG
MUL_1895|M.ulcerans_Agy99 QHAGADGANALNLDVLTACAAHLNPAVTRLAGGLLLIGYGAKVGLAPFHG
MSMEG_0846|M.smegmatis_MC2_155 G--------TLNLAELGVRLTDLPPGTRTAIFAVLLVAFGIKAAVFPLSA
TH_4005|M.thermoresistible__bu G--------TLNMAELAVRLDDIAPGTRTALFAVLLIAFGIKAAVFPLSS
Mflv_0164|M.gilvum_PYR-GCK G--------TLNLAEIAVRLDDVPEGTRMALFAVLLVAFGIKAAVFPLSA
Mvan_0742|M.vanbaalenii_PYR-1 G--------TLNLAEIAVRLDDVPEGTRMALFAVLLVAFGIKAAVFPLSA
MAB_0634c|M.abscessus_ATCC_199 G--------TLNMAEIALRADGIPSGTRMAIFAVLLVGFAIKAAVFPLST
MLBr_00335|M.leprae_Br4923 Y------------------PGRTGTSLALLTGQIIDVGYSGLATLALVCL
. :: :.:. . : .
Mb0089|M.bovis_AF2122/97 WLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNGLL
Rv0086|M.tuberculosis_H37Rv WLADAHSQAPAPVSALMSGVLLAVAFSVLIRLRPILDAVSGPAYLRNGLL
MAV_5110|M.avium_104 WLADAHSQAPAPVSALMSGVLLSVAMSVLIRITPIVGAAAGPTFLRAGLL
MMAR_1658|M.marinum_M WLADAHSQAPAPVSALMSGVLLSVAFSVLIRLRPVIDAAVGPGYLRAGLL
MUL_1895|M.ulcerans_Agy99 WLADAHSQAPAPVSALMSGVLLSVAFSVLIRLRPVIDAAVGPGYLRAGLL
MSMEG_0846|M.smegmatis_MC2_155 WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPDGG---LDSVLL
TH_4005|M.thermoresistible__bu WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRTHSLLFPGAG---LDPLLL
Mflv_0164|M.gilvum_PYR-GCK WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGG---MDRILL
Mvan_0742|M.vanbaalenii_PYR-1 WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGG---MDRVLL
MAB_0634c|M.abscessus_ATCC_199 WLPDSYPTAPAPVTAVFAGLLTKVGVYAIIRAHSLLFPGGG---LNTVLL
MLBr_00335|M.leprae_Br4923 FVIAVLTTCYRPLLFATVDPEVAAACGVPVHALGIVF-------------
:: . . *: . .. . :: ::
Mb0089|M.bovis_AF2122/97 VVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAAL
Rv0086|M.tuberculosis_H37Rv VVGLATLLVAVLMLTVTGDVKRMLAYSSMEHMGLIAIAAAAGTTLAIAAL
MAV_5110|M.avium_104 TVGLVTLFVAALMLTVTGDVKRMLAYSSMENMGLIAIAAAAGTTLAIAAL
MMAR_1658|M.marinum_M TVGLTTVLIAAFLLTVVTDLKRMLAYSSMENMGLIAIAAAAGTKLAIAAL
MUL_1895|M.ulcerans_Agy99 TVGLTTVLIAAFLLTVVTDLKRMLAYSSMENMGLIAIAAAAGTKLAIAAL
MSMEG_0846|M.smegmatis_MC2_155 VAGLLTMVIGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALGNELGMAGA
TH_4005|M.thermoresistible__bu IAALATMLIGILGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTQLGMSGA
Mflv_0164|M.gilvum_PYR-GCK VAGLLTMVIGIFGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTQLGMAGA
Mvan_0742|M.vanbaalenii_PYR-1 VAGLLTMIIGIFGAIAQSDIKRLLSFTLVSHIGYMVFGIALSTHLGMSGA
MAB_0634c|M.abscessus_ATCC_199 VAALLTMIVGILGAIAQSDIKRLLSFTLVSHIGYMIFGIALSNELGMSGA
MLBr_00335|M.leprae_Br4923 -----AALVGLVAAQAVQVVGALLVMSLLITPAAAAAQVVASPVAAMVAA
: .:. . . : :* : : . . . .: .
Mb0089|M.bovis_AF2122/97 LLHVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVG
Rv0086|M.tuberculosis_H37Rv LLHVLAHGIGKTVLFLAGGQLQAAHDSTAIADITGVMRRSRLIGVSFAVG
MAV_5110|M.avium_104 LLHVLAHGVGKTVLFLAGGQLQAAHGSTAIADITGVVQRSHLIGGSFAVG
MMAR_1658|M.marinum_M LLHVLAHGIGKTVLFLAGGQLQSAHDSASIADITAVLSRSRVVGVSFAVG
MUL_1895|M.ulcerans_Agy99 LLHVLAHGIGKTVLFLAGGQLQSAHDSASIADITAVLSRSRVVGVSFAVG
MSMEG_0846|M.smegmatis_MC2_155 IYYVAHHIVVQTTLFLVVGLIERQAGASTLQRLGGLAAASPVLAFVWVVP
TH_4005|M.thermoresistible__bu IYYVAHHIVVQTTLFLVVGLIERQAGASTLQRLGGLAAASPLLAFVFVVP
Mflv_0164|M.gilvum_PYR-GCK IYYVAHHILVQTTLFLVVGLIERQAGASTLERLGGLAAASPLLAFVFVVP
Mvan_0742|M.vanbaalenii_PYR-1 IYYVAHHILVQTTLFLVVGLIERQAGASTLERLGGLAAASPLLAFVFVVP
MAB_0634c|M.abscessus_ATCC_199 IYYVAHHIIVQTTLFLVVGLIERQAGASSLNRLGGLAAASPLLAFVFVVP
MLBr_00335|M.leprae_Br4923 VIFAEVSAVGGVVLSLAPG-------------------------------
: .. : ..* *. *
Mb0089|M.bovis_AF2122/97 LIVLLGLPPFAMFASELAIARSLANER--LAWVLGAALLLIAIGFTALAR
Rv0086|M.tuberculosis_H37Rv LIVLLGLPPFAMFASELAIARSLANER--LAWVLGAALLLIAIGFTALAR
MAV_5110|M.avium_104 LIVLLGLPPFAMFASELALAHALADAR--LAWVLGAAMLLIAIAFAALVR
MMAR_1658|M.marinum_M VVVLLGLPPFAMFASEVSIARSLADSG--LAWVLGVTLLLMVVAFAALVA
MUL_1895|M.ulcerans_Agy99 VVVLLGLPPFAMFSSEVSIARSLANSG--LAWVLGVTLLLMVVAFAALVA
MSMEG_0846|M.smegmatis_MC2_155 ALNLGGIPPFSGFIGKIALMEAGAANGSALAWTLVAGGVVTSLLTLYVVA
TH_4005|M.thermoresistible__bu ALNLGGIPPFSGFIGKVALMEAGAADGSVLAWTLVGGSVVTSLLTLYVVA
Mflv_0164|M.gilvum_PYR-GCK ALNLGGIPPFSGFIGKVALLEAGAESGSVLAWILVAGSVITSLLTLYVVA
Mvan_0742|M.vanbaalenii_PYR-1 ALNLGGIPPFSGFIGKVALLEAGAQSGSVLAWALVAGSVATSLLTLYVVA
MAB_0634c|M.abscessus_ATCC_199 ALNLGGIPPFSGFIGKVALLEAGSLQGSVLAWALVAGGTITSLLTLYAVA
MLBr_00335|M.leprae_Br4923 -------VPVSVFVATISFLIY------LFCWLLGRHREVCA--------
*.: * . ::: :.* *
Mb0089|M.bovis_AF2122/97 NSGRMLLGTPAAGAPAITVPATAAAALMVG--------------------
Rv0086|M.tuberculosis_H37Rv NSGRMLLGTPAAGAPAITVPATAAAALMVG--------------------
MAV_5110|M.avium_104 NASRMLLGPAAAAAPPITAPTTVTAALLVG--------------------
MMAR_1658|M.marinum_M NSRRMLLGAASEGAPRIAVPATVAAALVTG--------------------
MUL_1895|M.ulcerans_Agy99 NSRRMLLGAASEGAPRIAVPATVAAALVTG--------------------
MSMEG_0846|M.smegmatis_MC2_155 RVWTKAFWRTRADAPEGHLSQAAPAVLLD---DGEDIEYADREGVGRMPI
TH_4005|M.thermoresistible__bu RVWTKAFWRSRADAPEGHLSAAAPAVLLD---DIEDIEFAERRHVGRMPV
Mflv_0164|M.gilvum_PYR-GCK RVWTKAFWRARKDAPEGHLSGPAPTALLDNTDETMDIEHSDRDDVGRMPV
Mvan_0742|M.vanbaalenii_PYR-1 RVWTKAFWRSRKDAPEGHLSGPAPAALLDNTDETMDIELADRDDVGRMPV
MAB_0634c|M.abscessus_ATCC_199 RVWTKAFWRPRSDAPEGDLAAAAPTALLD---DAEDVAFVDRADVGRIPA
MLBr_00335|M.leprae_Br4923 --------------------------------------------------
Mb0089|M.bovis_AF2122/97 ---------IVVSAALGITAGPLADLLGIAASNVGLP-------------
Rv0086|M.tuberculosis_H37Rv ---------IVVSAALGITAGPLADLLGIAASNVGLP-------------
MAV_5110|M.avium_104 ---------VAASIVLGVTAGPLTDLFSTAAGQLGALR------------
MMAR_1658|M.marinum_M ---------VVACIALGVTAGPLGGLFDAAAGQFGAN-------------
MUL_1895|M.ulcerans_Agy99 ---------VVACIALGVTAGPLGGLFDAAAGQFGAN-------------
MSMEG_0846|M.smegmatis_MC2_155 GMLIPTAALIVVGLVLTVAAGPIFAFSERAAAEVIDRGQYITAVLGETR-
TH_4005|M.thermoresistible__bu SMLVPTGGLILVGLALTIFAGPIVAYSERAAEQVLDRGRYIGAVIGEAP-
Mflv_0164|M.gilvum_PYR-GCK GMLAPTGALIVVGLALTVLAGPIIAYSDRAAAEVLDRSQYIGAVLGGQP-
Mvan_0742|M.vanbaalenii_PYR-1 GMLAPTGALIVVGLLLTILAGPIFGYSDRAAGEVIDRGQYIGAVLGGTR-
MAB_0634c|M.abscessus_ATCC_199 GMLAPTLGLIAVGVALTIFAGPIIAISDRAAAEVRDRTVYISAVLGGAPR
MLBr_00335|M.leprae_Br4923 --------------------------------------------------