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MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHA AVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAER QAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLL GAFSSAFFLYGVALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQG APTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSV AHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVG VMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEESGDTPH VAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3158 | nuoN | - | 100% (531) | NADH dehydrogenase subunit N |
| M. tuberculosis H37Rv | Rv3157 | nuoM | 2e-30 | 25.87% (429) | NADH dehydrogenase subunit M |
| M. tuberculosis H37Rv | Rv0086 | hycQ | 2e-30 | 25.47% (530) | hydrogenase HycQ |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3182 | nuoN | 0.0 | 100.00% (531) | NADH dehydrogenase subunit N |
| M. gilvum PYR-GCK | Mflv_4494 | - | 0.0 | 65.59% (526) | NADH dehydrogenase subunit N |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2147 | - | 1e-171 | 58.18% (538) | NADH dehydrogenase subunit N |
| M. marinum M | MMAR_1470 | nuoN | 0.0 | 83.02% (530) | NADH dehydrogenase I (chain N) NuoN (NADH- ubiquinone |
| M. avium 104 | MAV_4047 | - | 0.0 | 82.83% (530) | NADH dehydrogenase subunit N |
| M. smegmatis MC2 155 | MSMEG_2050 | nuoN | 0.0 | 66.03% (527) | NADH dehydrogenase subunit N |
| M. thermoresistible (build 8) | TH_1092 | nuoN | 0.0 | 66.29% (528) | PROBABLE NADH DEHYDROGENASE I (CHAIN N) NUON |
| M. ulcerans Agy99 | MUL_2472 | nuoN | 0.0 | 82.64% (530) | NADH dehydrogenase subunit N |
| M. vanbaalenii PYR-1 | Mvan_1872 | - | 0.0 | 65.23% (532) | NADH dehydrogenase subunit N |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3158|M.tuberculosis_H37Rv ----MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLA
Mb3182|M.bovis_AF2122/97 ----MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLA
MMAR_1470|M.marinum_M ----MILPSPSIEYFLLCPMLIVFGIAVIGVLAEAFLPRRLRYGAQVTLA
MUL_2472|M.ulcerans_Agy99 ----MILPSPSIEYFLLCPMLIVFGIAVVGVLAEAFLPRRLRYGAQVTLA
MAV_4047|M.avium_104 ---MMTLPTPSIQYFLLCPTLIVFGVAVAGVLAEAFLPRRIRYTAQVTLA
Mflv_4494|M.gilvum_PYR-GCK MNTLTPLPTPTVEYFFLSPMLIVLGAAVLGVLVEALLPRHLRYRAQAGLS
Mvan_1872|M.vanbaalenii_PYR-1 MN----IPTPTVEYGLISPMLIVLAAAVLGVLVEAFVPRGRRYAVQVTLS
MSMEG_2050|M.smegmatis_MC2_155 ------MITPSIEYGLLSPMLIVFGVAIAGVLIEALAPRQSRYPLQVTLA
TH_1092|M.thermoresistible__bu -----------VEYSLLLPMLIVFGVAIAGVLIEAFLPRRLRYRVQLTLT
MAB_2147|M.abscessus_ATCC_1997 MTDIGILPAPAIAYGALSPMLIMFGVAVVSVLVEAFVPRGHRLRTQLALA
: * : * **::. *: .** **: ** * * *:
Rv3158|M.tuberculosis_H37Rv LGGSAVALIAVIVVARSIHGSG-HAAVLGAIAVDRATLFLQGTVLLVTIM
Mb3182|M.bovis_AF2122/97 LGGSAVALIAVIVVARSIHGSG-HAAVLGAIAVDRATLFLQGTVLLVTIM
MMAR_1470|M.marinum_M LSGLVAAFVAVIVVARSIPVTG-RRAVLGSMAVDRPTLFLQGTVLLVAVM
MUL_2472|M.ulcerans_Agy99 LSGLVAAFVAVIVVARSIPVTG-RRAVLGSMAVDRPTLFLQGTVLLVEVM
MAV_4047|M.avium_104 LGGLVAALFAVIEVAESLPASG-RAAVLGAMAIDRPTLYLQGTVLLVAVM
Mflv_4494|M.gilvum_PYR-GCK LAALLAAFVAVVMVARDLPADGAVSAVMGAVAVDMPALFLQGTILAVGVL
Mvan_1872|M.vanbaalenii_PYR-1 IAALVASFVAVVLVARDLHGGSGSEAVMGAIAVDMPALFLQGTILVVGVL
MSMEG_2050|M.smegmatis_MC2_155 LGGLIATVVAVVFVARGLSGTPGRPAVLGAVVLDAPAVFLQGTIALVGIL
TH_1092|M.thermoresistible__bu LGGLVAALLAVLGLTDRLSGGGGDTAMMGAVVIDGPALFLQGTVVLLAIL
MAB_2147|M.abscessus_ATCC_1997 TVGILGAFVAVVALSGSH-----QVVMNGAVAIDGPTLYLQGLILVASGL
. :..**: :: .: *::.:* .:::*** : :
Rv3158|M.tuberculosis_H37Rv AVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERA
Mb3182|M.bovis_AF2122/97 AVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERA
MMAR_1470|M.marinum_M AVIFIAERSAHRVAAQTKTAVAAGSGGLDSFTPQASAVPGSDAEREAQRA
MUL_2472|M.ulcerans_Agy99 AVIFIAERSAHRVAAQTKTAVAAGSGGLDSFTPQASAVPGSDAEREAQRA
MAV_4047|M.avium_104 AVIFIAER--TQTKSDSKVAVVAGSGGLDSFTPQASAVPDSDAEREAERA
Mflv_4494|M.gilvum_PYR-GCK GVLLIGER------QIGVVEDSENGRGLDAFTPQASAVAGSVAEKVAARA
Mvan_1872|M.vanbaalenii_PYR-1 GILLIGER------QISAPGPDTEGRGLEAFTPQASAVPGSVAEKLATRA
MSMEG_2050|M.smegmatis_MC2_155 GIMLIAER------QKATVSAG-EARGLEDFTPQASAVAGSVAEQLATKT
TH_1092|M.thermoresistible__bu GVLLIAER------QIGS---RDPARGLDGFTPQASAVPGSVAEQVATRA
MAB_2147|M.abscessus_ATCC_1997 ALVVMAQR--RTVAAVPSAVGAGAGGGLDSFAAQASSVPGSEPERVLNRT
.::.:.:* **: *:.***:*..* .*: ::
Rv3158|M.tuberculosis_H37Rv GATQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARN
Mb3182|M.bovis_AF2122/97 GATQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARN
MMAR_1470|M.marinum_M GAAQTEIFPLLTLSVGGMMVFPAANDLLTMFVALEVLSLPLYLMCGLARH
MUL_2472|M.ulcerans_Agy99 GVAQTEIFPLLTLSVGGMMVFPAANDLLTMFVALEVLSLPLYLMCGLARH
MAV_4047|M.avium_104 GAAQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARH
Mflv_4494|M.gilvum_PYR-GCK GNIQTEVFPLTMFAVAGMLLFPAADDLLTMFIALEVLSLPLYLLCGMARR
Mvan_1872|M.vanbaalenii_PYR-1 GVIQTEVFPLTLFAIGGMLLFPAANDLLTMFIALEVLSLPLYLLCGLARR
MSMEG_2050|M.smegmatis_MC2_155 GVMQTEVFPLTMFAIGGMLLFPAADDLLTMFVALEVLSLPLYLLCGLARR
TH_1092|M.thermoresistible__bu GAVQTEVFPLTMFATGGMMLFGASDDLLTIFVALEVLSLPLYLLCGLARR
MAB_2147|M.abscessus_ATCC_1997 GITQTEIFPLTLFAIAGMMLFPACNDLLTMFVALEVFSLPLYVMCALARR
* ***:*** :: .**::* *.:****:*:****:*****::*.:**.
Rv3158|M.tuberculosis_H37Rv RRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDALAART
Mb3182|M.bovis_AF2122/97 RRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDALAART
MMAR_1470|M.marinum_M RRLLSQESALKYFLLGAFSSAFFLYGVALLYGATGSLTLTGIRDSLTARS
MUL_2472|M.ulcerans_Agy99 RRLLSQESALKYFLLGAFSSAVFLYGVALLYGATDSLTLTGIRDSLAARS
MAV_4047|M.avium_104 RRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLLLTGIRDALITRG
Mflv_4494|M.gilvum_PYR-GCK RRLLSQESAVKYFLLGAFSSAFFLYGAAMLYGYAGTLSFPGIADAVADGT
Mvan_1872|M.vanbaalenii_PYR-1 RRLLSQEASLKYFLLGAFSSAIFLYGAAMLYGYAGTLQLDGIADAVAAGT
MSMEG_2050|M.smegmatis_MC2_155 RRLLSQEAALKYFLLGAFSSAFFIYGAAMLYGSAGTLDLSGIAESVAAGS
TH_1092|M.thermoresistible__bu QRLLSQEAALKYFLLGAFSSAFFVYGVAMLYGYSGTLRLGGIADAVATPP
MAB_2147|M.abscessus_ATCC_1997 RRLLSQESALKYFLLGAFSSAFFLFGSAFVYGYAGTVELDAVARAVDADA
:******:::***********.*::* *::** :.:: : .: ::
Rv3158|M.tuberculosis_H37Rv D--DSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAAT
Mb3182|M.bovis_AF2122/97 D--DSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAAT
MMAR_1470|M.marinum_M D--MSMALVGVGLLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAAT
MUL_2472|M.ulcerans_Agy99 D--MSMALVGVGLLSVGLLFKVGAVPFHSWIPDVYQGAPTPTTGFMAAAT
MAV_4047|M.avium_104 D--TSLALVGVALLSVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAAT
Mflv_4494|M.gilvum_PYR-GCK G-TTSLGLIGVALLLVGILFKIGAVPFHSWIPDVYQGAPTPITAFMAAAT
Mvan_1872|M.vanbaalenii_PYR-1 G-RTSLALIGIALLLVGVLFKVGAVPFHSWIPDVYQGAPTPITAFMAAAT
MSMEG_2050|M.smegmatis_MC2_155 G-NTSLALLGVALLLVGVLFKVGAVPFHSWIPDVYQGAPTSITAFMAAAT
TH_1092|M.thermoresistible__bu GGSTALALIGIGLLMVGLLFKVGAVPFHSWIPDAYQGAPTAITAFMSAAT
MAB_2147|M.abscessus_ATCC_1997 G-ERSFLLLGVAMLSVGLLFKVGAVPFHFWVPDVYQGAPTPVTAFMAATT
. :: * *:.:* **:***:****** *:**.******. *.**:*:*
Rv3158|M.tuberculosis_H37Rv KVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKR
Mb3182|M.bovis_AF2122/97 KVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKR
MMAR_1470|M.marinum_M KVAAFGALLRVVYVALPPLHDQWRPVLWAISILTMAVGTITAVNQTNVKR
MUL_2472|M.ulcerans_Agy99 KVAAFGALLRVVYVALPPLHDQWRPVLWAISILTMAVGTITAVNQTNVKR
MAV_4047|M.avium_104 KVAAFGALLRVVYVALPPLHDQWRPVLWTISILTMAVGTITAVNQSDVKR
Mflv_4494|M.gilvum_PYR-GCK KIAAFGAMLRLFYVALPGLRDDWRPVLWAIAILTMVVGTVTAVTQTDVKR
Mvan_1872|M.vanbaalenii_PYR-1 KIAAFGAMLRLFYVALPGLRDDWRPVLWAIAILTMVVGTVTAVTQNDVKR
MSMEG_2050|M.smegmatis_MC2_155 KIAAFGAMLRIFYVAVPALRDDWRPVLWAIAILTMVVGTVTAVTQTDVKR
TH_1092|M.thermoresistible__bu KVAAFGALLRICHVALPALKDDWRPMLWAVAILTMVVGTVTAVTQTDVKR
MAB_2147|M.abscessus_ATCC_1997 KIAAFGALLRVLYVALPGITTDWRPVLWGVAIATMLIGSIGAVTQTDVKR
*:*****:**: :**:* : :***:** ::* ** :*:: **.*.:***
Rv3158|M.tuberculosis_H37Rv MLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVR
Mb3182|M.bovis_AF2122/97 MLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVR
MMAR_1470|M.marinum_M MLAYSSVAHVGFILTGVIADNSAGLSATLFYLVAYSFSTVGAFAIVGLVR
MUL_2472|M.ulcerans_Agy99 MLAYSSVAHVGFILTGVIADNSAGLSATLFYLVAYSFSTVGAFAIVGLVR
MAV_4047|M.avium_104 MLAYSSVAHVGFILTGVIADNHTGLSATLFYLLAYSFSTVGAFAIVGLIR
Mflv_4494|M.gilvum_PYR-GCK MLGYSAVAHTGFILTGVIAGNDAGVSSTLFYLFAYGFSTVGAFAVVGLVR
Mvan_1872|M.vanbaalenii_PYR-1 MLGYSAVAHSGFILTGVIAGSAAGLSSTLFYLFAYGFSTVGAFAVVSLVR
MSMEG_2050|M.smegmatis_MC2_155 MLAYSAVAHSGFILTGVIAANPAGVSSTLFYLFAYGFSTLGAFAVVGLIR
TH_1092|M.thermoresistible__bu MLAYSAVAHTGFILTGVIAANEAGVSSTLFYLFAYGFSSLGAFALVGLVR
MAB_2147|M.abscessus_ATCC_1997 MLAYSAVAHTGFLLTGVAAANERGVSSTLFYLAAYGFSTVGAFIIAGLVR
**.**:*** **:**** * . *:*:***** **.**::*** :..*:*
Rv3158|M.tuberculosis_H37Rv G------ADGSA--GSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPL
Mb3182|M.bovis_AF2122/97 G------ADGSA--GSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPL
MMAR_1470|M.marinum_M D------ANG-----VEDANLSHWAGLGQRSPIVGVMLSMFLLAFAGIPL
MUL_2472|M.ulcerans_Agy99 D------ADG-----VEDANLSHWAGLGQRSPIVGVMLSMFLLAFAGIPL
MAV_4047|M.avium_104 D------ADG-----VEDATLSHWAGLGQRSPIVGVMFSMFLLAFAGIPL
Mflv_4494|M.gilvum_PYR-GCK N------SDG-----EEDTAMARWAGLGKRYPLVGIVFSLFLLAFAGIPL
Mvan_1872|M.vanbaalenii_PYR-1 D------ADG-----EEDSAMARWAGLGKRYPVVGIVFSLFLLAFAGIPL
MSMEG_2050|M.smegmatis_MC2_155 N------AAG-----DEETSMAQWAGLGRRYPIVGVVFSLFLLAFAGIPL
TH_1092|M.thermoresistible__bu S------RDG-----EEATSMAAWAGLGRRHPLAGVVFSLFLLAFAGIPL
MAB_2147|M.abscessus_ATCC_1997 SGNADDGADGDYKDDDEVTDLRRWAGVGRRAPVLGIVFALFLLAFAGIPL
. * * : : ***:*:* *: *:::::**********
Rv3158|M.tuberculosis_H37Rv TSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEES
Mb3182|M.bovis_AF2122/97 TSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEES
MMAR_1470|M.marinum_M TSGFISKFSVFKAAAEGGAAPLVVIGVISSGVAAYFYVRVIVLMFFTEES
MUL_2472|M.ulcerans_Agy99 TSGFISKFSVFKAAAEGGAAPLVVIGVISSGVAAYFYVRVIVLMFFTEES
MAV_4047|M.avium_104 TSGFVSKLAVFKAAAQGGAVPLVIVGVVASGVAAYFYVRVIVSMFFTEAT
Mflv_4494|M.gilvum_PYR-GCK TSGFVGKFAVFKAAGEGGAIPLVVVGVVASAIAAYFYVRVIVLMFFTDSP
Mvan_1872|M.vanbaalenii_PYR-1 TSGFVSKFAVFKAAGEGGAIPLVVVGVIASAIAAYFYVRVIMLMFFTDRP
MSMEG_2050|M.smegmatis_MC2_155 TSGFVSKFAVFKAAGEGGAIPLVIIGVIASAVAAYFYVRVIVLMFFTEPP
TH_1092|M.thermoresistible__bu TSGFVAKFAVFKAAGEGGAIPLVVIGVIASAVAAYFYVRVIVLMFFTDPP
MAB_2147|M.abscessus_ATCC_1997 TSGFVSKFAVFEAAAAGGAMPLVVVGVMCSAIAAYFYVRVIVVMFFADPV
****:.*::**.**. .** ***::**:.*.:*********: ***::
Rv3158|M.tuberculosis_H37Rv GDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
Mb3182|M.bovis_AF2122/97 GDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
MMAR_1470|M.marinum_M SDTPQVVAPGILSKAAIAVCAAVTVLLGILPQPVLDLANQAAHLLH
MUL_2472|M.ulcerans_Agy99 SDTPQVVAPGILSKAAIAVCAAVTVLLGILPQPVLDLANQAAHLLH
MAV_4047|M.avium_104 EDTPHVVAPGILSKAAIAVCAAVTVALGVFPQPLLDLADQAAQLLH
Mflv_4494|M.gilvum_PYR-GCK DDAPAVVVPSVLTTAVVTVTAAVTFMLGALPQPLLDLADSADRFF-
Mvan_1872|M.vanbaalenii_PYR-1 DDAPTVVVPSALTTAVVTVTAAVTFALGALPQPLLDLANAADRFL-
MSMEG_2050|M.smegmatis_MC2_155 DDAPELVVPSGLSTAVVTVTAAVTFALGALPQPLLDLANSAETFLH
TH_1092|M.thermoresistible__bu SDAPEVVAPSGLTTAVVTVTAAVTFALGALPQPLLDLADSAVPFLR
MAB_2147|M.abscessus_ATCC_1997 EDSGVLRIPGPAVTVSIAVSALITVLLGVAPQPLLDLVENLADFVT
*: : *. .. ::* : :*. ** ***:***.: :.