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MPQAEPTQPHAPSCRKPSDARSWSDEERRRVQRRTLVVVIASQVLGGAGLAAGVSVGALLAKEMLGTESL AGIPAALFTLGSAAAAFSIGRLTQSWGRRVGLGIGFTAGGVGAAGVVVAAASDNAPLLFAALFIYGAGTA TNLQARYAGTDLADPSRRGTAISVALTATTLGAVAGPNLIAPMGQVAVALGIPALAGPFLLAAVAYVAAG SVLIALLRPDPYLVARQIDAASAREGDDTSVTAALRPTAGAYVGAVVMIVAQVAMAAIMTMTPVHMSGHH HGLSAVGLVIGLHIAAMYLPSLVTGVLVDRIGPHAMAVAAGITLLAAGLTAAFAPGDSLPLLVTALVLLG LGWNFGIISGTAFVVDATVPANRPRVQGSIDVLIAIAGAAGGGLSGVVMSAGGYAALSIACGVFALVLLP ALLWDRKRTPAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5926 | - | - | 100% (432) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_2778 | - | 7e-12 | 25.26% (380) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_2131 | - | 5e-11 | 24.80% (371) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3018 | - | 2e-09 | 25.61% (371) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_3420 | - | 5e-09 | 26.68% (371) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2994 | - | 2e-09 | 25.61% (371) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1299c | - | 1e-11 | 25.00% (384) | multidrug ABC transporter |
| M. marinum M | MMAR_0136 | - | 8e-09 | 26.58% (365) | intergral membrane protein |
| M. avium 104 | MAV_0138 | - | 8e-12 | 25.67% (374) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_5167 | - | 8e-14 | 28.17% (387) | major facilitator superfamily protein MFS_1 |
| M. thermoresistible (build 8) | TH_0476 | - | 2e-10 | 27.20% (364) | major facilitator superfamily protein MFS_1 |
| M. ulcerans Agy99 | MUL_4961 | - | 4e-10 | 27.40% (365) | intergral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5167|M.smegmatis_MC2_155 ------------------MPHTRR-FSFALLAYAFAAIMVGTTLPTPMYA
TH_0476|M.thermoresistible__bu ---------------------VRR-FAFPLLAYAFAAVMVGTTVPTPMYA
MAB_1299c|M.abscessus_ATCC_199 -----------------MIARLRRSAAFVLLAFSFSAVMIGTTMPTPMYA
Mb3018|M.bovis_AF2122/97 --------------MSRDPTGVGARWAIMIVSLGVTASSFLFINGVAFLI
Rv2994|M.tuberculosis_H37Rv --------------MSRDPTGVGARWAIMIVSLGVTASSFLFINGVAFLI
MMAR_0136|M.marinum_M --------------MTSGSAPQWLTRNLRVLSLVSLLQDAASELLYPLLP
MUL_4961|M.ulcerans_Agy99 --------------MTSGSAPQWLTRNLRVLSLVSLLQDAASELLYPLLP
MAV_0138|M.avium_104 ---------MMSSNVRAARNRPGRTDPQPPTGAPLFVGVLGLLLATGWVA
Mvan_5926|M.vanbaalenii_PYR-1 MPQAEPTQPHAPSCRKPSDARSWSDEERRRVQRRTLVVVIASQVLGGAGL
Mflv_3420|M.gilvum_PYR-GCK -MDAILHRPRAARDLKGAWVGSHLMASDARIRRARAASAALFLTNGALFA
MSMEG_5167|M.smegmatis_MC2_155 LYAEHMNFAV-------LTTT-VIYATYAGGVLFALLLFGRWSDAIGRRP
TH_0476|M.thermoresistible__bu VYAERLGFGV-------LTTT-VVFAGYTAGVLFALVVFGRWSDALGRRP
MAB_1299c|M.abscessus_ATCC_199 LYSQQMHFSV-------LTTT-VVYATYAAGVLFALLMFGGWSDVLGRRP
Mb3018|M.bovis_AF2122/97 PRLENARGTP-------LSHAGLLASMPSWGLVVTMFAWGYLLDHVGERM
Rv2994|M.tuberculosis_H37Rv PRLENARGTP-------LSHAGLLASMPSWGLVVTMFAWGYLLDHVGERM
MMAR_0136|M.marinum_M IYLTTVLGAP-------PSVVGAVEGAAEGAASLTKVVSGPLGDRFARRP
MUL_4961|M.ulcerans_Agy99 IYLATVLGAP-------PSVVGAVEGAAEGAASLTKIVSGPLGDRFARRP
MAV_0138|M.avium_104 NHFVGLMPAISDRDHLATTTLDGIFGIYALGLLPGLLVGGRTSDALGRRP
Mvan_5926|M.vanbaalenii_PYR-1 AAGVSVGALLAKEMLGTESLAGIPAALFTLGSAAAAFSIGRLTQSWGRRV
Mflv_3420|M.gilvum_PYR-GCK NLLPRFPEIKS-----DLAMSNAGYGAAVAAFSAGALLAGPAAGALIRRF
: . . . * .*
MSMEG_5167|M.smegmatis_MC2_155 ---MLLAGVAAALISAGVFLMADSVPVLLIGRIFSGLSAGIFTGTATAAV
TH_0476|M.thermoresistible__bu ---MLLAGVGCAIVSALVFLIAGSVPQLIAARFVSGMSAGIFTGTATAAV
MAB_1299c|M.abscessus_ATCC_199 ---LLLTGAGFAILSSVIFLFVDSVPLLLVARIVSGLSAGFFTGAATVAV
Mb3018|M.bovis_AF2122/97 ---VMAVGSALTAAAAYAAASVHSLLWIGVFLFLGGMAAGGCNSAGGRLV
Rv2994|M.tuberculosis_H37Rv ---VMAVGSALTAAAAYAAASVHSLLWIGVFLFLGGMAAGGCNSAGGRLV
MMAR_0136|M.marinum_M ---LIASGYGMAALGKLIVAAAGAWPGVLAGRVVDRLGKGLRGAPRDALL
MUL_4961|M.ulcerans_Agy99 ---LIASGYGMAALGKLIVAAAGAWPGVLAGRVVDRLGKGLRGAPRDALL
MAV_0138|M.avium_104 ---VALTGSAAALVGTVAMLLSQHSPALFAGRLIVGLGVGLAISAGTAWA
Mvan_5926|M.vanbaalenii_PYR-1 GLGIGFTAGGVGAAGVVVAAASDNAPLLFAALFIYGAGTATNLQAR-YAG
Mflv_3420|M.gilvum_PYR-GCK QSARVAVVTTVALASLIVTAAVAPTPLVFAATLLFAGASDAITDVAQNVN
. : .. .
MSMEG_5167|M.smegmatis_MC2_155 IEAAPPAWRTRAAAVATVANIGGLGTGP----LLAGLLVEYAPRPLHLSF
TH_0476|M.thermoresistible__bu IEAAPERRRSRAAAVATVANIGGLGAGP----LLAGILVQYAPWPLHLTF
MAB_1299c|M.abscessus_ATCC_199 IESAPETWRGRAAAVATVANTGGLGLGP----LLAGVLVQYAPWPTHLAF
Mb3018|M.bovis_AF2122/97 SGWFPPQQRGLAMGIRQTAQPLGIASG-------ALVIPELAERGVHAGL
Rv2994|M.tuberculosis_H37Rv SGWFPPQQRGLAMGIRQTAQPLGIASG-------ALVIPELAERGVHAGL
MMAR_0136|M.marinum_M VDGVEPAQRGRAFGFHRTMDTLGAVIGP----LLGLAGYELFDHQIGP-V
MUL_4961|M.ulcerans_Agy99 VDGVDPAQRGRAFGFHRTMDTLGAVIGP----LLGLAGYELFDHQIGP-V
MAV_0138|M.avium_104 SDLRGPAG----AATAGAVLTAGFAVGP----FAGGVLAWAGPSGVRASF
Mvan_5926|M.vanbaalenii_PYR-1 TDLADPSRRGTAISVALTATTLGAVAGPNLIAPMGQVAVALGIPALAGPF
Mflv_3420|M.gilvum_PYR-GCK ALRVQRNYGRSIINSLHAIWAAGAITGG---------LMGAGAIALGVPR
. * *
MSMEG_5167|M.smegmatis_MC2_155 VVHIVMAVLAGAAVFAVPETSSRSGSIGL--QRLSVPPEVRTVFVIAAIA
TH_0476|M.thermoresistible__bu WVHIVLMVLAAAAIAVAPETSPRTGRLGV--QRLSLPPQVRKVFAIASLA
MAB_1299c|M.abscessus_ATCC_199 VVHIGLVSIAVAALLFVPETAPKHGKLGR--QRLSLPPQVRATFAAAATA
Mb3018|M.bovis_AF2122/97 MFPAVVCTLAAVASVLGIVDPPRKSRTKA--SEQELASPYRGSSILWRIH
Rv2994|M.tuberculosis_H37Rv MFPAVVCTLAAVASVLGIVDPPRKSRTKA--SEQELASPYRGSSILWRIH
MMAR_0136|M.marinum_M LYLAVIPAVLSVLLITWVREPPRNLAKAK--PASILDGTRRLSRRYWAVV
MUL_4961|M.ulcerans_Agy99 LYLAVIPAMLSVLLIAWVREPPRNLAKAK--PASILDGTRRLPRRYWAVV
MAV_0138|M.avium_104 ALAAAILALAAFAVVAAPQPSPVTAPADPDGEETADAAPQGISRALSWAM
Mvan_5926|M.vanbaalenii_PYR-1 LLAAVAYVAAGSVLIALLRPDPYLVARQIDAASAREGDDTSVTAALRPTA
Mflv_3420|M.gilvum_PYR-GCK AIHLVVAAVLFCAIVCAAYPYLLKGPDHDDHPSARDGGTARVGPMVYLTL
MSMEG_5167|M.smegmatis_MC2_155 -----AFAGFAVTGMYTAVAPSFLSNVIGVDNHAVAGAVACSIFAAS-AV
TH_0476|M.thermoresistible__bu -----AFAGFAVTGLFTAVAPSFLAEVIGVRNHAVAGAVAASIFAAS-AV
MAB_1299c|M.abscessus_ATCC_199 -----GFAGFAALGSFTAVAPGFLSGVLGIDNHAVAGASVFLTFGSS-CV
Mb3018|M.bovis_AF2122/97 -----AASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTISQLLGAL
Rv2994|M.tuberculosis_H37Rv -----AASALLMMPQTVTVTFMLVWLINHHGWSVAQAGVLVTISQLLGAL
MMAR_0136|M.marinum_M -----SFLVLFSIAN--FPDALLLLRLKQIGFSVVGVIMAYVGYNAVYAL
MUL_4961|M.ulcerans_Agy99 -----SFLVLFSIAN--FPDALLLLRLKQIGFSVVGVIMAYVGYNAVYAL
MAV_0138|M.avium_104 -----PLAPWVFASATLGFVTIPGRLHTALAAPVAAGTATLIVNGVSGAV
Mvan_5926|M.vanbaalenii_PYR-1 GAYVGAVVMIVAQVAMAAIMTMTPVHMSGHHHGLSAVGLVIGLHIAAMYL
Mflv_3420|M.gilvum_PYR-GCK ------LALVALAMAGATVEDAGSSWATLYLRDELGAPGAVAAFGYVALV
:
MSMEG_5167|M.smegmatis_MC2_155 TQVLANRVQP---GRAVAVGCAILIAGMLILTAALLFSSLPALIAAAVVS
TH_0476|M.thermoresistible__bu TQVLGASVSP---RRAVAVGCALLIVGMVFLAAALVWSSLPALIATAVVA
MAB_1299c|M.abscessus_ATCC_199 AQILTRRVAA---AKALLIGCTILLTGMLLVVLALHTSSLPWYLASAVVV
Mb3018|M.bovis_AF2122/97 GRVAVGRWSD---HVGSRMRPVRLIAAAAAATLFLLAAVDNEGSRYDVLL
Rv2994|M.tuberculosis_H37Rv GRVAVGRWSD---HVGSRMRPVRLIAAAAAATLFLLAAVDNEGSRYDVLL
MMAR_0136|M.marinum_M ASFPAGALAD---RLG---RPVVYAFGLVFFAVGYLGLGITTDTATAWAL
MUL_4961|M.ulcerans_Agy99 ASFPVGALAD---RLG---RPVVYAFGLVLFAVGYLGLGITTDTATAWAL
MAV_0138|M.avium_104 QVLARALRWG---PQAGTAGAVLAALGYAVAAAAPSTLTPALGVPLFVVL
Mvan_5926|M.vanbaalenii_PYR-1 PSLVTGVLVDRIGPHAMAVAAGITLLAAGLTAAFAPGDSLPLLVTALVLL
Mflv_3420|M.gilvum_PYR-GCK GFLFVGRLIG--DRLVDRYGDRAVARAGGMITAVGMGIALAFPTVPGTIV
. . .
MSMEG_5167|M.smegmatis_MC2_155 GVGQGMSFSRGLAAIAEKTPPDRRAEVSSTYFVVAYVAISLPVVGEGLSA
TH_0476|M.thermoresistible__bu GAGQGLSFSRGLAAVSARTPSDQRGEVSSTYFVVAYVALLVPVIGEGWAA
MAB_1299c|M.abscessus_ATCC_199 GIGQGISFSRGLAAIADRTPEDNRAEVTSSYFVVAYIGIALPVIGEGLAA
Mb3018|M.bovis_AF2122/97 MIAISVIAVLDNGLEATAITEYAGPYWSGRALGIQNTTQRLMAAAGPPLF
Rv2994|M.tuberculosis_H37Rv MIAISVIAVLDNGLEATAITEYAGPYWSGRALGIQNTTQRLMAAAGPPLF
MMAR_0136|M.marinum_M IAAYGLFTACYDGVGKAWISAIVSAELQSSAQGVFQGLSGFAVLAAGLWA
MUL_4961|M.ulcerans_Agy99 IAAYGLFTACYDGVGKAWISAIVSAELQSSAQGVFQGLSGFAVLAAGLWA
MAV_0138|M.avium_104 GCASGLCLREGLIDLEAAAPQRLRGGLTGLFYVVTYIGFGLPLILASVRP
Mvan_5926|M.vanbaalenii_PYR-1 GLGWNFGIISGTAFVVDATVPANRPRVQGSIDVLIAIAGAAGGGLSGVVM
Mflv_3420|M.gilvum_PYR-GCK GFAAAGLGVATVIPAAMRTADELPGLRPGTGLTMLTWLMRIGFLGAPLIV
. . :
MSMEG_5167|M.smegmatis_MC2_155 Q----------HWGLR-PAGIAFALAVCVLAVICLVAILVEESRQRRAES
TH_0476|M.thermoresistible__bu H----------HWGLR-TAGISFAVGVAVLAIGCLIAILIQESRDPQAI-
MAB_1299c|M.abscessus_ATCC_199 Q----------AWGLR-TAGVTFALAVAALAALCLIAVIWQERPSRTEAL
Mb3018|M.bovis_AF2122/97 GSLITTAAYPTAWALCGVFPLAAVPLVPVRLLPPGLETRARRQSVRRHRW
Rv2994|M.tuberculosis_H37Rv GSLITTAAYPTAWALCGVFPLAAVPLVPVRLLPPGLETRARRQSVRRHRW
MMAR_0136|M.marinum_M G---------FLWGVDGRLPLLISGGAGAVFALALLAAAAGTR--RRAR-
MUL_4961|M.ulcerans_Agy99 G---------FLWGVDGRLPLLISGGAGAVFALALLAAAAGTR--RRAR-
MAV_0138|M.avium_104 G-----------------VATAILSGMAVLAVTAAVGRAARLRRDDHRQN
Mvan_5926|M.vanbaalenii_PYR-1 S----------------AGGYAALSIACGVFALVLLPALLWDRKRTPAS-
Mflv_3420|M.gilvum_PYR-GCK G------------VVADAVSLRAGLLSVPIAGIAIIALAAALLTARRRR-
:
MSMEG_5167|M.smegmatis_MC2_155 AELSAST-----------------------------
TH_0476|M.thermoresistible__bu ------------------------------------
MAB_1299c|M.abscessus_ATCC_199 APVSTG------------------------------
Mb3018|M.bovis_AF2122/97 WQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAITPPT
Rv2994|M.tuberculosis_H37Rv WQAVRCHAWPNGPRRPGPPGQPRRVRQGGTAITPPT
MMAR_0136|M.marinum_M ------------------------------------
MUL_4961|M.ulcerans_Agy99 ------------------------------------
MAV_0138|M.avium_104 ------------------------------------
Mvan_5926|M.vanbaalenii_PYR-1 ------------------------------------
Mflv_3420|M.gilvum_PYR-GCK ------------------------------------