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MTGTPGVGLSAWRFVTTFGVVSLLADIVYEGARSITGPLLASLGATAVVVGVVTGVGEAAALILRMVSGP LADRTGRFWTWTIGGYFLTVVTVPFLGAVGVLWAAAALIIAERVGKAVRSPAKDTLLSHATAVTGRGRGF AVHEAMDQIGAVAGPLAVAAMLVVFGGDYAPTLALLAVPGVGVLALLAWLRVRVPEPARYEVEAAPSTKP VARVSFLRSLPRSFWTYAGFSAATMLGFTTFGVLSFHQVERGVVHVAVVPVIYAAAMVADALAALATGWV YDKVGAVVLGALPVMAGLVPALAFNDHLVPVVAGALVWGAAVGIQESTLRAVVADLVEPARRATAYGIYA AVLGCAAAAGGALTGYLYGQSVPLLVGVVIGVQAIALAVLPVVRRVAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2778 | - | - | 100% (398) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5926 | - | 7e-12 | 25.26% (380) | major facilitator superfamily transporter |
| M. vanbaalenii PYR-1 | Mvan_5855 | - | 8e-10 | 25.57% (348) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2288 | - | 1e-137 | 64.54% (392) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_1475 | - | 1e-16 | 26.65% (379) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv2265 | - | 1e-137 | 64.54% (392) | integral membrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4615 | - | 1e-149 | 70.45% (379) | major facilitator transporter |
| M. marinum M | MMAR_0136 | - | 1e-30 | 29.72% (397) | intergral membrane protein |
| M. avium 104 | MAV_3974 | - | 1e-11 | 25.20% (377) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3421 | - | 4e-10 | 25.40% (374) | inner membrane metabolite transport protein YdfJ |
| M. thermoresistible (build 8) | TH_3412 | - | 5e-05 | 25.71% (175) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_4961 | - | 4e-32 | 30.03% (393) | intergral membrane protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2288|M.bovis_AF2122/97 -----MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSI
Rv2265|M.tuberculosis_H37Rv -----MGANGDVALSRIGATRPALSAWRFVTVFGVVGLLADVVYEGARSI
MAB_4615|M.abscessus_ATCC_1997 -------------------MPQRLSAWRFVTTFGVISMLADIVYEGARSI
Mvan_2778|M.vanbaalenii_PYR-1 ---------------MTGTPGVGLSAWRFVTTFGVVSLLADIVYEGARSI
MMAR_0136|M.marinum_M ----------------MTSGSAPQWLTRNLRVLSLVSLLQDAASELLYPL
MUL_4961|M.ulcerans_Agy99 ----------------MTSGSAPQWLTRNLRVLSLVSLLQDAASELLYPL
MAV_3974|M.avium_104 --------------------------------------MVALGYGVISPA
MSMEG_3421|M.smegmatis_MC2_155 MADQHPSAEAARGSDDPEYARNLKRATLAASVGSALEYYDFALYSLASAL
Mflv_1475|M.gilvum_PYR-GCK --------------------MAPLSPTAQRAPLLAAGFTTAFGAHAVAGT
TH_3412|M.thermoresistible__bu --------------MTQCAVRAGAREWAGLGVLAVPTVLLGLDVTVLYLV
Mb2288|M.bovis_AF2122/97 TG-PLLAS-LGATGLVVG--VVTGVGEAAALGLRLVSGPLADRSRRFWAW
Rv2265|M.tuberculosis_H37Rv TG-PLLAS-LGATGLVVG--VVTGVGEAAALGLRLVSGPLADRSRRFWAW
MAB_4615|M.abscessus_ATCC_1997 TG-PLLAS-LGASALVVG--VVTGIGEAAALALRLVSGPLTDRTRKFWAW
Mvan_2778|M.vanbaalenii_PYR-1 TG-PLLAS-LGATAVVVG--VVTGVGEAAALILRMVSGPLADRTGRFWTW
MMAR_0136|M.marinum_M LP-IYLTTVLGAPPSVVG--AVEGAAEGAASLTKVVSGPLGDRFAR-RPL
MUL_4961|M.ulcerans_Agy99 LP-IYLATVLGAPPSVVG--AVEGAAEGAASLTKIVSGPLGDRFAR-RPL
MAV_3974|M.avium_104 LP-TFARS-FGVSIKAVT--FLVTVFSLSRLCFAPISGLLTERLGE-RRI
MSMEG_3421|M.smegmatis_MC2_155 IFGEIFFPALGASAGTVASLATLAIGFVARPVGGLFFGALGDRLGRKWVL
Mflv_1475|M.gilvum_PYR-GCK LG--TTTTGTAASLLTLG--AMLAIYDGAEVILKPLFGTLADRIGA-RTV
TH_3412|M.thermoresistible__bu LP----AVAADLAPSPVQTLWIMDAYGFFIAGFLITMGTLGDRIGRRRLL
. : * * :*
Mb2288|M.bovis_AF2122/97 TIAGYTLTVVTVPLLGIAG-------ALWVACALVIAERVGKAVRGPAKD
Rv2265|M.tuberculosis_H37Rv TIAGYTLTVVTVPLLGIAG-------ALWVACALVIAERVGKAVRGPAKD
MAB_4615|M.abscessus_ATCC_1997 TISGYALTVVTVPFLGVSS-------VLWIAATLVIAERVGKAVRSPAKD
Mvan_2778|M.vanbaalenii_PYR-1 TIGGYFLTVVTVPFLGAVG-------VLWAAAALIIAERVGKAVRSPAKD
MMAR_0136|M.marinum_M IASGYGMAALGKLIVAAAG-------AWPGVLAGRVVDRLGKGLRGAPRD
MUL_4961|M.ulcerans_Agy99 IASGYGMAALGKLIVAAAG-------AWPGVLAGRVVDRLGKGLRGAPRD
MAV_3974|M.avium_104 YIGGLLIVAVSTAACAFSQ-------AYWQLMLCRVFSGVGSTMFYVSAL
MSMEG_3421|M.smegmatis_MC2_155 MLTIALMGGSSTLIGVLPTGEQVGALAPILLVVLRIAQGFGAGAEQAGAT
Mflv_1475|M.gilvum_PYR-GCK LIAGLAVFAVASLSFAVAD-------ETAWLWAARLGQGIGAAAFSPAAS
TH_3412|M.thermoresistible__bu TIGVTAFAGASVLAALAPS-------AELLIVARALLGVAGATLMPSTLS
. : *
Mb2288|M.bovis_AF2122/97 TLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALG
Rv2265|M.tuberculosis_H37Rv TLLSHAASVTGRGRGFAVHEALDQVGAMIGPLTVAGMLAITGNAYAPALG
MAB_4615|M.abscessus_ATCC_1997 TLLSHATAVTGRGKGFAVHEAMDQIGAITGPLLVAGMLALTHVNYLPTFA
Mvan_2778|M.vanbaalenii_PYR-1 TLLSHATAVTGRGRGFAVHEAMDQIGAVAGPLAVAAMLVVFGGDYAPTLA
MMAR_0136|M.marinum_M ALLVDGVEPAQRGRAFGFHRTMDTLGAVIGPLLGLAGYELFDHQIGPVLY
MUL_4961|M.ulcerans_Agy99 ALLVDGVDPAQRGRAFGFHRTMDTLGAVIGPLLGLAGYELFDHQIGPVLY
MAV_3974|M.avium_104 GLMIHISPADARGRIAGLFTTSFMVGAVGGP--AVGGLAAGWGLTAPFVV
MSMEG_3421|M.smegmatis_MC2_155 TLMAEYSPVRRRGFYSALPFVGIMLGTLLASAVFVGLGQVPDDALLGWVW
Mflv_1475|M.gilvum_PYR-GCK ALVARLAPASGQGRAFGTYGSYKSVGYTLGP--LIGGAIVTFGGLQALFA
TH_3412|M.thermoresistible__bu LISNMFVDAAQRALAIGVWATMFAVGMAAGP--VVGGALVDRFWWGAAFL
: :. . :* .. . .
Mb2288|M.bovis_AF2122/97 VLTLPGGAALA-LLLWLQRRVPRPESY-----------------------
Rv2265|M.tuberculosis_H37Rv VLTLPGGAALA-LLLWLQRRVPRPESY-----------------------
MAB_4615|M.abscessus_ATCC_1997 ILALPGGATLL-LLFWLRRRVPHPERY-----------------------
Mvan_2778|M.vanbaalenii_PYR-1 LLAVPGVGVLA-LLAWLRVRVPEPARYE----------------------
MMAR_0136|M.marinum_M LAVIPAVLSVL-LITWVR----EPPRN-----------------------
MUL_4961|M.ulcerans_Agy99 LAVIPAMLSVL-LIAWVR----EPPRN-----------------------
MAV_3974|M.avium_104 YGVAMLGVALV-LFLGLRNSALAAPPP-----------------------
MSMEG_3421|M.smegmatis_MC2_155 RIPFLASIFLIGVAVLIRLRLKESPTFVT---------------------
Mflv_1475|M.gilvum_PYR-GCK VMAALAAAVAVWAAVAVPRLAVLPRTR-----------------------
TH_3412|M.thermoresistible__bu LAVPVAAAVLLGARLLPEYADPQAGRLDLRSVALSLLAILAAIYAVKHVA
.
Mb2288|M.bovis_AF2122/97 -----------EDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTF
Rv2265|M.tuberculosis_H37Rv -----------EDCPVVLGNPSAPRPWALPAQFWLYCGFTAITMLGFGTF
MAB_4615|M.abscessus_ATCC_1997 -----------EHDDYIRGAADRPHKLSLPLSFWLYSGFTAITMIGFATF
Mvan_2778|M.vanbaalenii_PYR-1 ----------VEAAPSTKPVARVSFLRSLPRSFWTYAGFSAATMLGFTTF
MMAR_0136|M.marinum_M -------------LAKAKPASILDGTRRLSRRYWAVVSFLVLFSIANFPD
MUL_4961|M.ulcerans_Agy99 -------------LAKAKPASILDGTRRLPRRYWAVVSFLVLFSIANFPD
MAV_3974|M.avium_104 --------------PTRSTVTMREALRVRAYQSALLSNFATGWSAFGLRM
MSMEG_3421|M.smegmatis_MC2_155 ----------LEKRDQVSQKPFRELLQSSRPTVWRGIGLRMAENGGSYIY
Mflv_1475|M.gilvum_PYR-GCK -------------------QTLLDTVRRFSESSFVTPTLALAAATAALSA
TH_3412|M.thermoresistible__bu VHGVDGVAVAACALAAAAATVFVHRQRRLDAPLLDVTLFADRAFTAALTV
:
Mb2288|M.bovis_AF2122/97 GLLSFH--------MVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDR
Rv2265|M.tuberculosis_H37Rv GLLSFH--------MVSHGVLAAAMVPVVYAAAMAADALTALASGFSYDR
MAB_4615|M.abscessus_ATCC_1997 GVLSFH--------MVQRGVLPVPAVPIVYAAAMAADAVAALLSGWAYDR
Mvan_2778|M.vanbaalenii_PYR-1 GVLSFH--------QVERGVVHVAVVPVIYAAAMVADALAALATGWVYDK
MMAR_0136|M.marinum_M ALLLLR--------LKQIG-FSVVGVIMAYVGYNAVYALASFPAGALADR
MUL_4961|M.ulcerans_Agy99 ALLLLR--------LKQIG-FSVVGVIMAYVGYNAVYALASFPVGALADR
MAV_3974|M.avium_104 ALVPLF--------VSDVMGRGIGTIGVVLAAFAGGNALAVVPSGYLSDR
MSMEG_3421|M.smegmatis_MC2_155 QTLSIT--------YVSALGVQKSVGPLAVAIGAVIGFFVIPFAGSLSDR
Mflv_1475|M.gilvum_PYR-GCK GVGFLP--------VLGTDFGLSPVVTGAVVSVLALTTAVVQPLAGRAAD
TH_3412|M.thermoresistible__bu LLIGLIGVGGTMYLVTQFLQLVEGLTPVRAGWWMGPPALAMFVAAIGAPL
: . .
Mb2288|M.bovis_AF2122/97 YGAK------TLAVLPILSILVVLFAF--TDNVTMVVIGTLVWGAAVGIQ
Rv2265|M.tuberculosis_H37Rv YGAK------TLAVLPILSILVVLFAF--TDNVTMVVIGTLVWGAAVGIQ
MAB_4615|M.abscessus_ATCC_1997 VGPK------SLAALPIVGATVPMLAF--TDSLPGIVLGALLWGAAVGIQ
Mvan_2778|M.vanbaalenii_PYR-1 VGAV------VLGALPVMAGLVPALAF--NDHLVPVVAGALVWGAAVGIQ
MMAR_0136|M.marinum_M LGRP------VVYAFGLVFFAVGYLGLGITTDTATAWALIAAYGLFTACY
MUL_4961|M.ulcerans_Agy99 LGRP------VVYAFGLVLFAVGYLGLGITTDTATAWALIAAYGLFTACY
MAV_3974|M.avium_104 MGRR------TLLIVGLVTSGAATVWLGFVASLPVFLVAAGVVGVVTGIY
MSMEG_3421|M.smegmatis_MC2_155 FGRMRVY--RVGAVIQLVLAAVAWPLLSLGNPVLTVVVIAIAYGVGVNVM
Mflv_1475|M.gilvum_PYR-GCK SGRIS----LTSGLFTGVVVTAAGVAAAALPGLVGLLGGAVVIGVGCGLI
TH_3412|M.thermoresistible__bu IARRVRPGVVMAATLGVSVLGYAVLASAGRGDGPAVVVAFAFVYLGLGAI
. .
Mb2288|M.bovis_AF2122/97 ESTLRGVVADLVASPRRA----------SAYGVFAAGLG--AATAGGGAL
Rv2265|M.tuberculosis_H37Rv ESTLRGVVADLVASPRRA----------SAYGVFAAGLG--AATAGGGAL
MAB_4615|M.abscessus_ATCC_1997 ESTLRAVVADLVPPPRRA----------TAYGVYAAVLG--TATAIGGAL
Mvan_2778|M.vanbaalenii_PYR-1 ESTLRAVVADLVEPARRA----------TAYGIYAAVLG--CAAAAGGAL
MMAR_0136|M.marinum_M DGVGKAWISAIVSAELQS----------SAQGVFQGLSG--FAVLAAGLW
MUL_4961|M.ulcerans_Agy99 DGVGKAWISAIVSAELQS----------SAQGVFQGLSG--FAVLAAGLW
MAV_3974|M.avium_104 MSPLQAAVADILGNEARAGLPVATVQMMSDLGAIVGSMA--VGWAAEQIG
MSMEG_3421|M.smegmatis_MC2_155 LGAQCAALPELFGSRHRYIG-------VAVSREFSAIIAGGIAPFVGALL
Mflv_1475|M.gilvum_PYR-GCK TPLAFTMLARSTPEERLG------------QTMGAAEIGRECGDAAGPLV
TH_3412|M.thermoresistible__bu AALGTDIVVGAAPAAKSGS--------AAAMSETVQELGIAVGVALLGSV
: . .
Mb2288|M.bovis_AF2122/97 IGWL------YDIS--IGTLVVV--------VIALELMALVMMFAIRLPR
Rv2265|M.tuberculosis_H37Rv IGWL------YDIS--IGTLVVV--------VIALELMALVMMFAIRLPR
MAB_4615|M.abscessus_ATCC_1997 TGYL------YGVS--IPMLIAV--------VGVIQLVALITAAPTLLRH
Mvan_2778|M.vanbaalenii_PYR-1 TGYL------YGQS--VPLLVGV--------VIGVQAIALAVLPVVR--R
MMAR_0136|M.marinum_M AGFL------WGVDGRLPLLISG--------GAGAVFALALLAAAAGTRR
MUL_4961|M.ulcerans_Agy99 AGFL------WGVDGRLPLLISG--------GAGAVFALALLAAAAGTRR
MAV_3974|M.avium_104 YGWG------FFISGVVLLIAAVGWVMAPETRTATELEADLMAASRTSSR
MSMEG_3421|M.smegmatis_MC2_155 LSWFNNSWVPLAAYVIILTLITLYATLRTPETRARDLTLLTNADGDSESE
Mflv_1475|M.gilvum_PYR-GCK VAAI-------AAASTVPFGFLG---------LAAVVAASGVGVRRGRGR
TH_3412|M.thermoresistible__bu TAAV------YRSRMTGPEGVAEGVGGPDAERLAESLPAAVSVADRVPGE
. .
Mb2288|M.bovis_AF2122/97 VAPS--------------------------------------
Rv2265|M.tuberculosis_H37Rv VAPS--------------------------------------
MAB_4615|M.abscessus_ATCC_1997 AGQV--------------------------------------
Mvan_2778|M.vanbaalenii_PYR-1 VAR---------------------------------------
MMAR_0136|M.marinum_M RAR---------------------------------------
MUL_4961|M.ulcerans_Agy99 RAR---------------------------------------
MAV_3974|M.avium_104 CEQQL-------------------------------------
MSMEG_3421|M.smegmatis_MC2_155 IAARPEPLAQSYRNDAAAVVGR--------------------
Mflv_1475|M.gilvum_PYR-GCK VGGVG-------------------------------------
TH_3412|M.thermoresistible__bu AVRLAQDAFAAGVNIAALIGGAAVVVVAVVCATALRHLRPLD